Eye Exam POM – March 18, 2020
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Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors
pharmaceutics Article Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors Hyeong Min Kim 1,†, Hyounkoo Han 2,†, Hye Kyoung Hong 1, Ji Hyun Park 1, Kyu Hyung Park 1, Hyuncheol Kim 2,* and Se Joon Woo 1,* 1 Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea; [email protected] (H.M.K.); [email protected] (H.K.H.); [email protected] (J.H.P.); [email protected] (K.H.P.) 2 Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Korea; [email protected] * Correspondence: [email protected] (H.K.); [email protected] (S.J.W.); Tel.: +82-2-705-8922 (H.K.); +82-31-787-7377 (S.J.W.); Fax: +82-2-3273-0331 (H.K.); +82-31-787-4057 (S.J.W.) † These authors contributed equally to this work. Abstract: In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time– concentration values in the acceptor chamber across five isolated rabbit tissues for each drug molecule. We determined the outward direction permeability of the RCS and CS and calculated the neural retina permeability. The permeability coefficients of RCS and CS were as follows: ganciclovir, 13.78 ± 5.82 and 23.22 ± 9.74; brimonidine, 15.34 ± 7.64 and 31.56 ± 12.46; bevacizumab, 0.0136 ± 0.0059 and 0.0612 ± 0.0264 (×10−6 cm/s). -
The Sclera C
The Sclera c. Stephen Foster Maite Sainz de la Maza The Sclera Foreword by Frederick A. lakobiec With 134 Illustrations and 33 Color Plates Springer Science+Business Media, LLC C. Stephen Foster, MD Associate Professor of Ophthalmology Harvard Medical School Director, Immunology and Uveitis Service Massachusetts Eye and Ear Infirmary Boston, MA 02114 USA Maite Sainz de la Maza, MD, PhD Assistant Professor of Ophthalmology Central University of Barcelona 08036 Barcelona Spain Cover illustration: The eye of a patient with rheumatoid arthritis who has developed pro gressively destructive necrotizing scleritis. Library of Congress Cataloging-in-Publication Data Foster, C. Stephen (Charles Stephen), 1942- The sclera/C. Stephen Foster and Maite Sainz de la Maza. p. cm. Includes bibliographical references and index. ISBN 978-1-4757-2345-8 ISBN 978-1-4757-2343-4 (eBook) DOI 10.1007/978-1-4757-2343-4 1. Sclera-Diseases. I. Maza, Maite Sainz de lao II. Title. [DNLM: 1. Scleritis. 2. Sclera. WW 230 F754s 1993] RE328.F67 1993 617.7' 19-dc20 DNLMIDLC for Library of Congress 93-10235 Printed on acid-free paper. © 1994 Springer Science+ Business Media New York Originally published by Springer-Verlag New York, Inc. in 1994 Softcover reprint of the hardcover 1st edition 1994 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher, Springer Science+Business Media, LLC. except for brief excerpts in connection with reviews or, scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. -
Extraocular Muscles Orbital Muscles
EXTRAOCULAR MUSCLES ORBITAL MUSCLES INTRA- EXTRA- OCULAR OCULAR CILIARY MUSCLES INVOLUNTARY VOLUNTARY 1.Superior tarsal muscle. 1.Levator Palpebrae Superioris 2.Inferior tarsal muscle 2.Superior rectus 3.Inferior rectus 4.Medial rectus 5.Lateral rectus 6.Superior oblique 7.Inferior oblique LEVATOR PALPEBRAE SUPERIORIOS Origin- Inferior surface of lesser wing of sphenoid. Insertion- Upper lamina (Voluntary) - Anterior surface of superior tarsus & skin of upper eyelid. Middle lamina (Involuntary) - Superior margin of superior tarsus. (Superior Tarsus Muscle / Muller muscle) Lower lamina (Involuntary) - Superior conjunctival fornix Nerve Supply :- Voluntary part – Oculomotor Nerve Involuntary part – Sympathetic ACTION :- Elevation of upper eye lid C/S :- Drooping of upper eyelid. Congenital ptosis due to localized myogenic dysgenesis Complete ptosis - Injury to occulomotor nerve. Partial ptosis - disruption of postganglionic sympathetic fibres from superior cervical sympathetic ganglion. Extra ocular Muscles : Origin Levator palpebrae superioris Superior Oblique Superior Rectus Lateral Rectus Medial Rectus Inferior Oblique Inferior Rectus RECTUS MUSCLES : ORIGIN • Arises from a common tendinous ring knows as ANNULUS OF ZINN • Common ring of connective tissue • Anterior to optic foramen • Forms a muscle cone Clinical Significance Retrobulbar neuritis ○ Origin of SUPERIOR AND MEDIAL RECTUS are closely attached to the dural sheath of the optic nerve, which leads to pain during upward & inward movements of the globe. Thyroid orbitopathy ○ Medial & Inf.rectus thicken. especially near the orbital apex - compression of the optic nerve as it enters the optic canal adjacent to the body of the sphenoid bone. Ophthalmoplegia ○ Proptosis occur due to muscle laxity. Medial Rectus Superior Rectus Origin :- Superior limb of the tendonous ring, and optic nerve sheath. -
The Pupillary Light Reflex in the Critically Ill Patient
light must be high for the iris to be seen, which reduces Editorials the step increase induced by the penlight).6 If the pupillary light reflex amplitude is less than 0.3 mm and the maximum constriction velocity is less than 1 mm/s, the reflex is unable to be detected using a The pupillary light reflex in penlight.6 In conscious patients with Holmes-Adie and Argyll-Robertson pupils with ‘absent’ pupillary light the critically ill patient reflexes, small light reflexes have been detected using infrared pupillometry.7 Also in post-resuscitation non- brain dead critically ill patients with ‘absent’ pupillary The pupillary response to light is controlled by the reflexes, the reflex has been demonstrated using a autonomic nervous system. The direct pupillary light portable infrared pupillometer.6 reflex refers to miosis that occurs in the stimulated eye; In this issue of Critical Care and Resuscitation, the consensual pupillary light reflex refers to miosis that Thomas8 describes a case of Guillain Barré syndrome occurs in the other eye. The reflex has a latent period presenting with weakness and fixed dilated pupils who with length of the period, amplitude of the response, and subsequently became ‘locked in’ with absence of any the speed of the pupillary constriction dependent on the clinical response to external stimuli. A positive brain intensity of the stimulus employed.1 For the reflex to be stem auditory evoked response was used to indicate truly tested, an intense stimulus and close observation normal brain stem function. In another recent report, a are required. The reflex has afferent, efferent and central case of ‘reversible fixed dilated pupils’ was associated connections; therefore non-response to light (i.e. -
What's the Connection?
WHAT’S THE CONNECTION? Sharon Winter Lake Washington High School Directions for Teachers 12033 NE 80th Street Kirkland, WA 98033 SYNOPSIS Students elicit and observe reflex responses and distinguish between types STUDENT PRIOR KNOWL- of reflexes. They then design and conduct experiments to learn more about EDGE reflexes and their control by the nervous system. Before participating in this LEVEL activity students should be able to: Exploration, Concept/Term Introduction Phases ■ Describe the parts of a Application Phase neuron and explain their functions. ■ Distinguish between sensory and motor neurons. Getting Ready ■ Describe briefly the See sidebars for additional information regarding preparation of this lab. organization of the nervous system. Directions for Setting Up the Lab General: INTEGRATION Into the Biology Curriculum ■ Make an “X” on the chalkboard for the teacher-led introduction. ■ Health ■ Photocopy the Directions for Students pages. ■ Biology I, II ■ Human Anatomy and Teacher Background Physiology A reflex is an involuntary neural response to a specific sensory stimulus ■ AP Biology that threatens the survival or homeostatic state of an organism. Reflexes Across the Curriculum exist in the most primitive of species, usually with a protective function for ■ Mathematics animals when they encounter external and internal stimuli. A primitive ■ Physics ■ example of this protective reflex is the gill withdrawal reflex of the sea slug Psychology Aplysia. In humans and other vertebrates, protective reflexes have been OBJECTIVES maintained and expanded in number. Examples are the gag reflex that At the end of this activity, occurs when objects touch the sides students will be able to: or the back of the throat, and the carotid sinus reflex that restores blood ■ Identify common reflexes pressure to normal when baroreceptors detect an increase in blood pressure. -
The Complexity and Origins of the Human Eye: a Brief Study on the Anatomy, Physiology, and Origin of the Eye
Running Head: THE COMPLEX HUMAN EYE 1 The Complexity and Origins of the Human Eye: A Brief Study on the Anatomy, Physiology, and Origin of the Eye Evan Sebastian A Senior Thesis submitted in partial fulfillment of the requirements for graduation in the Honors Program Liberty University Spring 2010 THE COMPLEX HUMAN EYE 2 Acceptance of Senior Honors Thesis This Senior Honors Thesis is accepted in partial fulfillment of the requirements for graduation from the Honors Program of Liberty University. ______________________________ David A. Titcomb, PT, DPT Thesis Chair ______________________________ David DeWitt, Ph.D. Committee Member ______________________________ Garth McGibbon, M.S. Committee Member ______________________________ Marilyn Gadomski, Ph.D. Assistant Honors Director ______________________________ Date THE COMPLEX HUMAN EYE 3 Abstract The human eye has been the cause of much controversy in regards to its complexity and how the human eye came to be. Through following and discussing the anatomical and physiological functions of the eye, a better understanding of the argument of origins can be seen. The anatomy of the human eye and its many functions are clearly seen, through its complexity. When observing the intricacy of vision and all of the different aspects and connections, it does seem that the human eye is a miracle, no matter its origins. Major biological functions and processes occurring in the retina show the intensity of the eye’s intricacy. After viewing the eye and reviewing its anatomical and physiological domain, arguments regarding its origins are more clearly seen and understood. Evolutionary theory, in terms of Darwin’s thoughts, theorized fossilization of animals, computer simulations of eye evolution, and new research on supposed prior genes occurring in lower life forms leading to human life. -
A Model of Accommodative-Pupillary Dynamics Stanley Gordon Day Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1969 A model of accommodative-pupillary dynamics Stanley Gordon Day Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Electrical and Electronics Commons Recommended Citation Day, Stanley Gordon, "A model of accommodative-pupillary dynamics " (1969). Retrospective Theses and Dissertations. 4649. https://lib.dr.iastate.edu/rtd/4649 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. This dissertation has been microâhned exactly as received 69-15,607 DAY, Stanley Gordon, 1939- A MODEL OF ACCOMMODATIVE-PUPILLARY DYNAMICS. Iowa State University, Ph.D., 1969 Engineering, electrical University Microfilms, Inc., Ann Arbor, Michigan ®Copyright by STANLEY GORDON DAY 1969 A MODEL OF ACCOMMODATIVE-PUPILLARY DYNAMICS by Stanley Gordon Day A Dissertation Submitted to the Graduate Faculty in Partial Fulfillment of The Requirements for the Degree of DOCTOR OF PHILOSOPHY Major Subject : Electrical Engineering Approved: Signature was redacted for privacy. In Charge of Major Work Signature was redacted for privacy. Head of Major Department Signature was redacted for privacy. Dea^ of Gradulate College Iowa State University Of Science and Technology Ames, Iowa 1969 il TABLE OF CONTENTS Page DEDICATION iii INTRODUCTION 1 REVIEW OF LITERATURE 4 EQUIPMENT AND METHODS 22 RESULTS AND DISCUSSION 47 SUÎ4MARY AND CONCLUSIONS 60 BIBLIOGRAPHY 62 ACKNOWLEDGEMENTS 68 APPENDIX 69 i iii DEDICATION This dissertation is dedicated to Sandra R. -
The Proteomes of the Human Eye, a Highly Compartmentalized Organ
Proteomics 17, 1–2, 2017, 1600340 DOI 10.1002/pmic.201600340 (1 of 3) 1600340 The proteomes of the human eye, a highly compartmentalized organ Gilbert S. Omenn Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA Proteomics has now published a series of Dataset Briefs on the EyeOme from the HUPO Received: November 2, 2016 Human Proteome Project with high-quality analyses of the proteomes of these compartments Accepted: November 4, 2016 of the human eye: retina, iris, ciliary body, retinal pigment epithelium/choroid, retrobulbar optic nerve, and sclera, with 3436, 2929, 2867, 2755, 2711, and 1945 proteins, respectively. These proteomics resources represent a useful starting point for a broad range of research aimed at developing preventive and therapeutic interventions for the various causes of blindness. Keywords: Biomedicine / Biology and Disease-driven Human Proteome Project / End Blindness by 2020 / Eye proteome / EyeOme / Human Proteome Project See accompanying articles in the EyeOme series: http://dx.doi.org/10.1002/pmic.201600229; http://dx.doi.org/10.1002/pmic.201500188; http://dx.doi.org/10.1002/pmic.201400397 Proteomics has now published a series of four papers on compartments of the eye as shown in Fig. 1. As was noted [5], the human eye proteome [1–4]. Under the aegis of the Hu- it was not feasible to assess the quality of the data or estimate man Proteome Organization Biology and Disease-driven Hu- numbers of likely false positives in the heterogeneous studies man Proteome Project (HPP), the EyeOme was organized by from which these findings were summarized. -
Scleral Lenses and Eye Health
Scleral Lenses and Eye Health Anatomy and Function of the Human Eye How Scleral Lenses Interact with the Ocular Surface Just as the skin protects the human body, the ocular surface protects the human Scleral lenses are large-diameter lenses designed to vault the cornea and rest on the conjunctival tissue sitting on eye. The ocular surface is made up of the cornea, the conjunctiva, the tear film, top of the sclera. The space between the back surface of the lens and the cornea acts as a fluid reservoir. Scleral and the glands that produce tears, oils, and mucus in the tear film. lenses can range in size from 13mm to 19mm, although larger diameter lenses may be designed for patients with more severe eye conditions. Due to their size, scleral lenses consist SCLERA: The sclera is the white outer wall of the eye. It is SCLERAL LENS made of collagen fibers that are arranged for strength rather of at least two zones: than transmission of light. OPTIC ZONE The optic zone vaults over the cornea CORNEA: The cornea is the front center portion of the outer Cross section of FLUID RESERVOIR wall of the eye. It is made of collagen fibers that are arranged in the eye shows The haptic zone rests on the conjunctiva such a way so that the cornea is clear. The cornea bends light the cornea, overlying the sclera as it enters the eye so that the light is focused on the retina. conjunctiva, and sclera as CORNEA The cornea has a protective surface layer called the epithelium. -
98796-Anatomy of the Orbit
Anatomy of the orbit Prof. Pia C Sundgren MD, PhD Department of Diagnostic Radiology, Clinical Sciences, Lund University, Sweden Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Lay-out • brief overview of the basic anatomy of the orbit and its structures • the orbit is a complicated structure due to its embryological composition • high number of entities, and diseases due to its composition of ectoderm, surface ectoderm and mesoderm Recommend you to read for more details Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 3 x 3 Imaging technique 3 layers: - neuroectoderm (retina, iris, optic nerve) - surface ectoderm (lens) • CT and / or MR - mesoderm (vascular structures, sclera, choroid) •IOM plane 3 spaces: - pre-septal •thin slices extraconal - post-septal • axial and coronal projections intraconal • CT: soft tissue and bone windows 3 motor nerves: - occulomotor (III) • MR: T1 pre and post, T2, STIR, fat suppression, DWI (?) - trochlear (IV) - abducens (VI) Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Superior orbital fissure • cranial nerves (CN) III, IV, and VI • lacrimal nerve • frontal nerve • nasociliary nerve • orbital branch of middle meningeal artery • recurrent branch of lacrimal artery • superior orbital vein • superior ophthalmic vein Lund University / Faculty of Medicine / Inst. Clinical Sciences / Radiology / ECNR Dubrovnik / Oct 2018 Lund University / Faculty of Medicine / Inst. -
The Pupillary Light Reflex in Normal Subjects
Br J Ophthalmol: first published as 10.1136/bjo.65.11.754 on 1 November 1981. Downloaded from British Journal ofOphthalmology, 1981, 65, 754-759 The pupillary light reflex in normal subjects C. J. K. ELLIS From St Thomas's Hospital, London SE] SUMMARY In 19 normal subjects the pupillary reflex to light was studied over a range of stimulus intensities by infrared electronic pupillography and analysed by a computer technique. Increasing stimulus intensity was associated with an increase in direct light reflex amplitude and maximum rate of constriction and redilatation. Latency from stimulus to onset of response decreased with increas- ing stimulus intensity. The normal range for each of these parameters is given and the significance of these results in clinical pupillary assessment discussed. The technique of infrared pupillometry' has allowed PUPILLOMETRY the normal pupillary response to light to be studied in A Whittaker Series 1800 binocular infrared television detail. Lowenstein and Friedman2 have shown that pupillometer was used in this study. All recordings in response to light the pupil constricts after a latent were made in darkness with no correction for refrac- period and that the length of this latent period, the tive error. The eyes were illuminated from a low- copyright. amplitude of the response, and the speed of the intensity, invisible infrared source and observed by pupillary constriction are dependent on the stimulus means of a closed circuit television system sensitive to intensity employed. These findings have subse- infrared light. The pupils were displayed on television quently been confirmed.3" monitor screens providing instantaneous feedback of Borgmann6 gave 95% confidence limits in defining the quality of the pupil images. -
Anatomy and Physiology of the Afferent Visual System
Handbook of Clinical Neurology, Vol. 102 (3rd series) Neuro-ophthalmology C. Kennard and R.J. Leigh, Editors # 2011 Elsevier B.V. All rights reserved Chapter 1 Anatomy and physiology of the afferent visual system SASHANK PRASAD 1* AND STEVEN L. GALETTA 2 1Division of Neuro-ophthalmology, Department of Neurology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, USA 2Neuro-ophthalmology Division, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA INTRODUCTION light without distortion (Maurice, 1970). The tear–air interface and cornea contribute more to the focusing Visual processing poses an enormous computational of light than the lens does; unlike the lens, however, the challenge for the brain, which has evolved highly focusing power of the cornea is fixed. The ciliary mus- organized and efficient neural systems to meet these cles dynamically adjust the shape of the lens in order demands. In primates, approximately 55% of the cortex to focus light optimally from varying distances upon is specialized for visual processing (compared to 3% for the retina (accommodation). The total amount of light auditory processing and 11% for somatosensory pro- reaching the retina is controlled by regulation of the cessing) (Felleman and Van Essen, 1991). Over the past pupil aperture. Ultimately, the visual image becomes several decades there has been an explosion in scientific projected upside-down and backwards on to the retina understanding of these complex pathways and net- (Fishman, 1973). works. Detailed knowledge of the anatomy of the visual The majority of the blood supply to structures of the system, in combination with skilled examination, allows eye arrives via the ophthalmic artery, which is the first precise localization of neuropathological processes.