Long-Term Visual Outcomes of Laser-Treated Threshold Retinopathy

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Long-Term Visual Outcomes of Laser-Treated Threshold Retinopathy Eye (2010) 24, 14–20 & 2010 Macmillan Publishers Limited All rights reserved 0950-222X/10 $32.00 www.nature.com/eye 1,2,3 1,2,3 2,4 CLINICAL STUDY Long-term visual C-S Yang , A-G Wang , C-S Sung , W-M Hsu3,5, F-L Lee1,2 and S-M Lee1,2 outcomes of laser- treated threshold retinopathy of prematurity: a study of refractive status 1Department of at 7 years Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China Abstract important for early detection and timely 2Department of treatment of these ocular morbidities. Ophthalmology, National Purpose To assess the long-term visual Eye (2010) 24, 14–20; doi:10.1038/eye.2009.63; Yang-Ming University outcomes and refractive status in patients with published online 3 April 2009 School of Medicine, Taipei, diode laser-treated threshold retinopathy of Taiwan, Republic of China prematurity (ROP), and to investigate the Keywords: diode laser; retinopathy of causes of impaired visual function. 3Department of prematurity; visual outcome A total of 60 eyes of 30 consecutive Ophthalmology, Taipei Method Medical University, Taipei, patients with diode laser-treated threshold Taiwan, Republic of China ROP were recalled for assessment at the age of Introduction 7 years or more. 4 Department of Results There were 38 eyes (65.5%) achieving The sequelae of retinopathy of prematurity Anesthesiology, Taipei 6/12 or better vision, however, an unfavourable (ROP) is an important cause of infant blindness Veterans General Hospital, visual outcome (6/60 or worse) occurred in four 1 Taipei, Taiwan, Republic of and visual disability in the world. The 10-year China eyes (6.9%). One eye (1.7%) had unfavourable outcome study of the Cryotherapy for structural outcome. Of these 60 laser-treated Retinopathy of Prematurity Cooperative Group 5Department of eyes, 46 eyes (77.0%) were myopic, the overall (CRYO-ROP) has demonstrated the long-term Ophthalmology, Shuang-Ho mean spherical equivalent was À3.87 D. benefit of cryotherapy on eyes with threshold Hospital, Taipei, Taiwan, Anisometropia (X1.5 D) was also noted in 14 ROP.2 Recently, laser photocoagulation therapy Republic of China patients (46.7%). Strabismus was present in has almost replaced cryotherapy for retinal nine patients (30.0%). Perinatal neurological Correspondence: S-M Lee, ablation of active ROP. Laser therapy is reported Department of events of intraventricular haemorrhage to be less traumatic with better structural and Ophthalmology, (IVH) were identified in eight children functional outcomes compared with eyes Taipei Veterans General (26.7%), periventricular leucomalacia (PVL) treated with cryotherapy in threshold ROP.3–5 Hospital, in eight children (26.7%), and cerebral Moreover, the study of the Early Treatment for National Yang-Ming palsy (CP) in four children (13.3%). There University, ROP Cooperative Group (ETROP) revealed 201 Sec. 2, Shih-Pai Road, was a statistically significant association earlier treatment improved grating visual acuity Taipei 11217, of the presence of strabismus with PVL and retinal structural outcomes for Taiwan, (P ¼ 0.002). The presence of anisometropia was subthreshold ROP at the age of 9 months as Republic of China a significant risk factor associated with poor compared with conventional threshold ROP Tel: þ 886 2 2875 7325; visual outcome of 6/15 or worse in laser-treated 6 Fax: þ 886 2 2876 1351. treatment. E-mail: smlee@ ROP (P ¼ 0.002). The visual outcome of premature infants with vghtpe.gov.tw Conclusion The majority of patients with regressed ROP is attributed to both structural diode laser-treated threshold ROP had and functional outcomes. Myopia, strabismus, Received: 29 September favourable anatomical and visual outcomes. anisometropia, astigmatism, and amblyopia are 2008 However, anisometropia, advanced refractive common problems in eyes with regressed ROP. Accepted in revised form: error, strabismus, and perinatal neurological 5 March 2009 Therefore, the importance of long-term follow- Published online: 3 April events remain important causes of impaired up of these children cannot be overemphasized. 2009 visual function. Long-term follow-up is very However, few studies with recent data Laser retinopathy of prematurity visual outcomes C-S Yang et al 15 concerning the long-term functional outcomes after laser treatment. Six patients were excluded from this study therapy and subsequent refractive status of threshold because they were lost to follow-up. The remaining ROP in Asia are available.7 30 children were recruited in this study with informed The purpose of this study is to present our experience parental consent. The patients were recalled at the age about the long-term visual outcomes of premature of 7 years to the eye clinic at Taipei Veterans General infants who received diode laser photocoagulation for Hospital for complete ophthalmologic assessment by threshold ROP during a 7-year follow-up. In this study, the clinicians (CY and AW). The following clinical we highlight the refractive status in these patients. parameters were recorded at each examination. Additionally, we also investigate the causes of impaired visual function in laser-treated threshold ROP. Visual acuity The best-corrected visual acuity (BCVA) was determined Patients and methods by Snellen chart at 6 m. Patients wore the glasses with The study protocol was approved by the Institutional the cycloplegic refraction determined by the Review Board of Taipei Veterans General Hospital. From autorefractometer and it was refined. To include all data January 1997 to December 2000, premature infants who in the statistical analysis and comparison, visual acuity weighed less than 2000 g of birth body weight or were was converted as the log of the minimum angle of less than 34 weeks of gestational age were screened for resolution (logMAR) value, and any eye with vision less ROP in the neonatal newborn room or intensive care unit than 1/60 was assigned as logMAR score of 2.0. Also for at Taipei Veterans General Hospital by a single statistical purpose, when analysing the probable risk ophthalmologist (CY). factors associated with poor visual outcome, visual At the first ophthalmic examination, the eyes of high- acuity of 6/12 or better was considered a good visual risk premature infants were screened at postnatal age of outcome, and visual acuity of 6/15 or worse a poor 4–6 weeks under indirect ophthalmoscope.8,9 The stage visual outcome. and severity of ROP was classified according to the International Classification of ROP (ICROP).10 Follow-up Refraction retinal examination was performed every 1–2 weeks until ROP regression, complete vasculogenesis of retina, or Cycloplegic refraction of the eyes was determined with development of threshold ROP. Threshold disease of desktop computer autorefractometer (Topcon ROP was defined as X5 contiguous or 8 cumulative Corporation, Tokyo, Japan) after instillation of 1% clock-hours of extraretinal neovascularization stage 3 cyclopentolate hydrochloride eye drops twice at a 10 min ROP associated with plus disease within zones I or II. interval. Refractive error was converted to the spherical Plus disease represented the dilatation and tortuosity of equivalent (SE). Myopia was divided into three retinal blood vessels in the posterior pole. Rush disease categories according to its magnitude (dioptre): 0–3.0, was defined as ROP in zone 1 with plus disease, which 3.1–6.0, and 46.0 D. Those with astigmatism were progressed rapidly within days. Infants with threshold classified as having errors of 0–1.5, 1.6À3.0, and 43.0 D. disease received retinal ablation laser photocoagulation Children with high myopia 46.00 D, anisometropia therapy within 72 h of diagnosis. X1.5 D, or astigmatism 43.0 D were considered to have Data were retrospectively collected from the medical advanced refractive error. records. Thirty-seven premature babies, who were hospitalized in the neonatal unit at Taipei Veterans Structural assessment General Hospital from 1997 to 2000 and had received diode laser (810 nm wavelength) treatment (Iris Medical Indirect ophthalmoscopy was performed to detect any Instruments Inc., Mountain View, CA, USA) therapy structural sequelae, including straightening of arcade under laser indirect ophthalmoscope for threshold ROP, vessels, macular distortion or dragging, macular fold, or were identified. The setting of laser treatment was tractional retinal detachment. 250–300 mW at the creamy-white laser intensity, near confluence pattern, and placed to the retina avascular Orthoptic assessment zone anterior to the fibrovascular ridge. Of the 37 children with laser-treated threshold ROP, Cover test, prism cover test, and ocular movements were one infant who had zone I rush disease rapidly evaluated to detect any abnormality of ocular motility. progressed to stage 5 despite photocoagulation. Strabismus was defined as a latent symptomatic or a Unfortunately, this patient died before the age of manifest squint, as well as patients who had received 6 months, and this was not attributed to ROP laser previous strabismus surgery. Eye Laser retinopathy of prematurity visual outcomes C-S Yang et al 16 Perinatal neurological events information of functional outcome of laser-treated eyes is shown in Table 1. The laser-treated eyes had a mean The presence of intraventricular haemorrhage (IVH) or visual acuity of 20/46, with 38 eyes (65.5%) achieving periventricular leucomalacia (PVL) was documented 6/12 or better vision (Table 2). However, an unfavourable from the record of cranial ultrasound. Any neurological
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