DTP Vaccines Could Protect Against COVID-19

1 Cross-reactive immunity from combination DTP vaccines could protect against COVID-19

2 Short title: DTP vaccines could protect against COVID-19

3 Pedro A Reche †

4 Department of Inmunology & O2, Faculty of Medicine, University Complutense of Madrid, Ciudad

5 Universitaria, Pza. Ramón y Cajal, 28040 Madrid, Spain.

6 † Corresponding author: Dr. Pedro A Reche; EM: [email protected]

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1 Abstract

3 The recently emerged SARS-Cov-2 causing the ongoing COVID-19 pandemic is particularly virulent

4 in the elderly while children are largely spared. Here, we explored the potential role of cross-reactive

5 immunity acquired from vaccinations and exposure to common human pathogens in protection and

6 pathology of COVID-19. To that end, we sought for peptide matches to SARS-CoV-2 (identity ≥

7 80%, in at least 8 residues) in the proteomes of 25 human pathogens and in vaccine antigens, and

8 subsequently predicted their T and B cell reactivity to identify potential cross-reactive epitopes. We

9 found that viruses subject to pediatric vaccinations do not contain cross-reactive epitopes with SARS-

10 CoV-2 to support that they can provide any general protection against COVID-19. Likewise,

11 common viruses including rhinovirus, respiratory syncytial virus, influenza virus and several

12 herpesviruses are also poor or null sources of cross-reactive immunity to SARS-CoV-2, discarding

13 that immunological memory against these viruses can have any protective or pathological role in

14 COVID-19. In contrast, we found combination vaccines for treating diphtheria, tetanus and pertussis

15 infectious diseases (DTP vaccine) to be significant sources of potential cross-reactive immunity to

16 SARS-CoV-2. DTP cross-reactive epitopes with SARS-CoV-2 include numerous CD8 and CD4 T

17 cell epitopes with broad population coverage and potentially neutralizing B cell epitopes in SARS-

18 CoV-2 Spike protein. Worldwide children receive several DTP vaccinations, including three-four

19 doses the first year of life and one at 4-6 year of age. Moreover, a low antigenic Tdap dose is also

20 given at age 9-14. Thereby, children may well be protected from SARS-CoV-2 through cross-

21 reactive immunity elicited by DTP vaccinations, supporting testing in the general population to

22 prevent COVID-19.

24 Word count = 263

25 Keywords = COVID-19, SARS-CoV-2, epitope, cross-reactive immunity, DTP vaccine

26 Acknowledgments: The author thanks Dr. Esther M. Lafuente for comments and motivation.

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1 Introduction

3 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is new emergent virus identified in

4 late 2019 as the etiological agent behind a mysterious outbreak of pneumonia in Wuhan, China [1,2].

5 The world health organization (WHO) latter named the disease as coronavirus disease 19 (COVID-

6 19) to account for the variety of clinical manifestations associated with SARS-CoV-2 infections [3,4].

7 The infectivity and pathogenicity SARS-CoV-2 has taken the world unguarded, leading to the

8 ongoing COVID-19 pandemic.

10 SARS-CoV-2 infection can be asymptomatic and the course of COVID-19 can range from mild to

11 severe and death [5]. COVID-19 cases and severity vary widely between different countries. For

12 example, COVID-19 deaths per million reported in Spain are 606, while in Serbia, with a similar

13 population density and geographical latitude are 30 (https://www.worldometers.info/coronavirus/).

14 COVID-19 also varies between individuals, and medical conditions such hypertension and obesity are

15 risk factors [5]. However, the strongest correlation factor in COVID-19 cases and severity is age. In

16 fact, the majority of CODID-19 fatalities occur among the elderly (90% of the victims are over 70

17 years) while the pediatric population is largely spared [6]. The large impact of COVID-19 in the

18 geriatric population is somewhat expected, since their ability to mount immune responses to new

19 pathogens is deteriorated [7]. Yet, the virulence of the virus appears to be related to a

20 disproportionate immune response, and indeed some patients appear to benefit from drugs with

21 immunomodulatory properties [8]. That newborns and infants, with undertrained adaptive immune

22 systems, are safe from COVID-19 is unexpected, but telling.

24 Humans are not immunologically naïve, or not for long. When exposed to a new infection the host

25 immune system preferentially engage existing cross-reactive memory B and T cells [9,10]. The

26 promiscuity in antigen-recognition repertoires in memory B and T cells allows for quicker responses

27 to multitude of antigens, saving energy and resources to the host. Activation of cross-reactive

28 memory B and T cells can lead to protective immunity but also induce life-threatening

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1 immunopathology [9,10]. In this context, we reasoned that children are likely protected from SARS-

2 CoV-2 by cross-reactive adaptive immunity elicited through vaccinations. Immunity elicited by

3 vaccines wanes over time and heterologous adaptive immunity towards common pathogens may

4 contribute to the severity of the disease in adults.

6 Adaptive immunity is driven by the recognition by T and B cells of small antigen fragments know as

7 epitopes [11]. B cell epitopes are also the targets of antibodies and they need to be readily free and

8 exposed to the solvent for recognition. In contrast, T cells recognize epitopes bound to mayor

9 histocompatibility complex (MHC) molecules displayed in the cell surface of antigen presenting cells

10 [11]. Thereby, to test our hypothesis and identify potential sources of cross-reactive immunity to

11 SARS-CoV-2, we conducted a systematic search for peptide matches to SARS-CoV-2 in 25 human

12 pathogens including 18 viruses and 7 bacteria –the majority targeted by vaccinations– and in selected

13 vaccine antigens, and predicted their T and B cell reactivity. Among the viruses without available

14 vaccine, we considered herpes simplex virus 1 and 2, Epstein-Barr virus, human cytomegalovirus,

15 human rhinovirus A, B and C and respiratory syncytial virus A and B, which are all prevalent in the

16 population. After these analyses, we will show that selected viral proteomes are very poor sources of

17 cross-reactive immunity to SARS-CoV-2, discarding that current pediatric vaccinations for viral

18 diseases provide any general protection against COVID-19. Moreover, we will show evidence that

19 cross-reactive immunity from combination tetatus, diphteria and pertussis (DTP) vaccines could be

20 protecting children against SARS-Cov-2 and could protect the general population.

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1 2 Methods

4 Pathogen and vaccine antigen sequences

6 The amino acids sequences encoded by the genomes of 25 human pathogens in FASTA format were

7 obtained from after the GenBank entries indicated in Table 1. The amino acid sequences of antigens

8 included in diphteria (D), tetanus (T) and pertussis cellular (wP) and acellular (aP) vaccines, were

9 obtained upon the proteomics projects PXD009289 and PXD013804 deposited in the Proteomics

10 Identification Database (PRIDE) by the authors [12,13](Table 1). The amino acid sequence of the

11 antigens included the meningococcal B vaccine Bexsero® (MenB) were obtained upon the PRIDE

12 proteomic project PXD011622 [14].

13 14 Table 1. Amino acid sequences from pathogens and vaccines considered in this study Pathogen NCBI Accesion Proteins/CDS Mumps virus (MuV) NC_002200 8 Measles virus (MV) NC_001498 8 Rubella Virus (RuV) NC_001545 2 Hepatitis B virus (HBV) NC_003977 8 Varicella Zoster Virus (VZV) NC_001348 73 Polio Virus (PoV) NC_002058 1 Influenza A virus (IAV) NC_026422 … NC_026429 12 Influenza B virus (IBV) NC_002204… NC_002211 10 Rotavirus A (RTV) NC_011500 … NC_011510 12 Pappiloma Virus (PaV) NC_027779 6 Herpes simplex virus 1 (HHV1) NC_001806 77 Herpes simplex virus 2 (HHV2) NC_001798 77 Epstein-Barr virus (EBV) NC_007605 94 human cytomegalovirus (HCMV) NC_006273 169 human rhinovirus A (HRVA) NC_038311 1 human rhinovirus B (HRVA) NC_038312 1 human rhinovirus C (HRVA) NC_009996 1 Human immunodeficiency 1 (HIV1) NC_001802 10 Bacille Calmette-Guérin (BCG) NC_008769 3807 Bordetella pertussis (Bpe) NC_002929 3359 Corynebacterium diphtheriae (Cdi) NZ_LN831026 2171 Clostridium tetani (Cte) NC_004557& NC_004565 2725 Haemophilus influenzae (Hin) NC_000907 1597 Neisseria meningitidis (serogroup B) NC_003112 1960 Streptococcus pneumoniae (Spn) NC_003098 1821 Vaccine Antigens PRIDE PROJECT Protein/CDS Tetanus (T): C. tetani PXD009289, PXD013804 601 Diphteria (D): C. diphtheriae PXD009289, PXD013804 340 Acellular pertussis (aP): B.pertussis PXD013804 25 Whole pertussis (wP): B.pertussis PXD013804 1852

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Meningocal B (MenB): N. meningitidis PXD011622 267 1

2 Identification of SARS-CoV-2 peptide matches in pathogens and vaccine antigens

4 Overlapping 15mer peptides with 10 residues overlap were generated for each amino acid coding

5 sequence (CDS) encoded by SARS-Cov-2 reference genome (NCBI accession NC_045512) covering

6 their entire length. Peptides were used as queries in similarity searches using BLASTP [15] against

7 custom made databases formatted for BLAST usage. BLAST formatted databases were generated

8 upon FASTA files including the selected proteomes and vaccine antigens described elsewhere in

9 Methods. BLAST searches were performed with default parameters and the expected value set to

10 10,000. BLAST alignments were parsed using PERL scripts and hit subject sequences consisting of 8

11 or more residues with an identity ≥ 80% were selected as peptide matches with SARS-Cov-2.

13 Determining peptide identity with human and microbiome proteins

15 Identity between SARS-CoV-2 peptides and hits with human and microbiome proteins was obtained

16 through local BLAST searches using an expectation value of 10,000. Human microbiome proteins

17 were obtained from the NIH Human Microbiome Project [16] and included 6320906 amino acid

18 sequences from species colonizing any/all body parts. Human proteins included 113275 amino acid

19 sequences and consisted of reference proteins linked to the human GRCh38 genome ensemble

20 (https://www.ncbi.nlm.nih.gov/genome/guide/human/). Amino acid sequences of human and

21 microbiome proteins were downloaded as FASTA files and formatted for BLAST searches.

23 Prediction of T cell reactivity

25 T cell reactivity (presence of T cell epitopes) of peptides was assessed by predicting their binding to

26 human leukocyte antigen (HLA) molecules. Peptide binding was predicted to HLA class I (HLA I)

27 molecules HLA-A*01:01, HLA-A*02:01, HLA-A*03:01, HLA-A*11:01, HLA-A*23:01, HLA-

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1 A*24:02, HLA-B*07:02, HLA-B*08:01, HLA-B*35:01, HLA-B*40:01, HLA-B*44:02, HLA-

2 B*44:03 using IEDB MHC I binding tool (http://tools.iedb.org/mhci/) with default recommended

3 method through the RESTful interface. At least one of these HLA I molecules are expressed by ~

4 95% of the world population regardless of the ethnic background as computed by the EPISOPT

5 method [17]. Models used to predict binding to HLA I molecules were the appropriated for peptides

6 with 8 and 9 residues. For longer peptides, the predicted binding was obtained evaluating all

7 encompassing 9mer peptides. A 2% percentile rank cutoff was chosen to consider that binding had

8 occurred. Peptide binding was also predicted to HLA class II (HLA II) HLA-DR molecules

9 encompassing the β chains HLA-DRB1*01:01, HLA-DRB1*03:01, HLA-DRB1*04:01, HLA-

10 DRB1*04:05, HLA-DRB1*07:01, HLA-DRB1*08:02, HLA-DRB1*09:01, HLA-DRB1*11:01,

11 HLA-DRB1*12:01, HLA-DRB1*13:02, HLA-DRB1*15:01 HLA-DRB3*01:01 HLA-DRB3*02:02

12 HLA-DRB4*01:01, HLA-DRB5*01:01 using the IEDB MHC II binding tool

13 (http://tools.iedb.org/mhcii/) with default recommended method through the RESTful interface. A

14 10% percentile rank cutoff was chosen to consider that binding had occurred. HLA-DR molecules

15 incorporate a non-polymorphic α chain and the selected β chains are expressed by ~81% of the

16 population as computed by the IEDB coverage tool (http://tools.iedb.org/population/)[18].

18 Prediction of B cell reactivity

20 B cell or antibody reactivity (presence of B cell epitopes) of peptides was predicted using BepiPred1.0

21 [18] at the IEDB Analysis Resource (http:// http://tools.iedb.org/bcell/). BepiPred predicts linear B-

22 cell epitopes, and reports antigenicity values per residue (ai), upon which we calculated a global value

23 of peptide antigenicity or B cell/Antibody reactivity (B) using Equation 1.

"i=l a 25 B = i=1 i Eq. 1 l

7-26 ! 1 Where l is the total number of residues in the peptide. Peptides with B values ≥ 0.4 were considered

2 as antigenic or potential B cell epitopes.

4 Other procedures

6 Virion surface ectodomains of SARS-CoV-2 Spike (S), membrane (M) and envelope (E) proteins

7 were identified form UNIPROT annotation records P0DTC2, P0DTC5 and P0DTC4, respectively.

8 PyMOL Molecular Graphics System, Version 1.8 Schrödinger, was used to map and visualize B cell

9 epitopes on 3D structures. PDB files with three-dimensional coordinates of SARS-Cov-2 S, M and E

10 glyproteins were obtained from Zhong Lab (https://zhanglab.ccmb.med.umich.edu/COVID-19/) and

11 residue relative solvent accessibility (RSA) of peptides mapping in these proteins was computed using

12 NACCESS [19]. We used the non-parametric Kruskal-Wallis test to compare COVID-19 cases and

13 death rates in European countries, including Asian countries from former URSS, with regard to the

14 inclusion of DTaP or DTwP vaccines. Vaccination data was obtained form

15 (https://apps.who.int/immunization_monitoring/) and death rates from

16 (https://www.worldometers.info/coronavirus/).

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1 Results and Discussion

3 Identification cross-reactive immunity to SARS-CoV-2

5 Adaptive immunity is mediated by B and T cells which recognize small fragments, epitopes, in the

6 target antigens. Thereby, to identify sources of potential cross-reactive immunity to SARS-CoV-2,

7 we devised a method to search for peptide matches between SARS-CoV-2 and sources of interest

8 (details in Methods). Briefly, we partitioned the entire SARS-CoV-2 into 15 mer peptides with 10

9 residues overlap and used them as query in modified BLAST searches against subject proteomes. We

10 then selected ungapped subject hits with 8 or more residues and ≥ 80% identity to SARS-CoV-2 as

11 potential sources of cross-reactive immunity. We next predicted B cell and T cell reactivity of

12 peptide hits using relevant epitope prediction methods (details in Methods). T cells can be divided in

13 CD4 and CD8 T cells which recognize peptides displayed in the cell surface of antigen presenting

14 cells bound to class I and class II MHC molecules, respectively. Therefore, we anticipated CD4 and

15 CD8 T cell epitopes by predicting peptide binding to class I and class II human MHC molecules (in

16 human known as HLA molecules for Human Leukocyte Antigens). For realization of T cell cross-

17 reactivity, both peptide hits and equivalent SARS-Co-V peptides have to bind to the same class I

18 and/or class II HLA molecules. Peptide hits with B-cell epitope scores ≥ 0.4 were considered to be

19 cross-reactive for B-cell/antibody mediated immunity.

21 We first sought for cross-reactive immunity to SARS-Cov-2 in the proteomes of 25 human pathogens.

22 The selected pathogens included 18 viruses and 7 bacteria. Among the viruses we considered

23 Influenza (A and B), various herpesviruses (Epstein Bar Virus, human cytomegalovirus and herpes

24 simplex virus 1 and 2), human rhinovirus (HRV) A, B and C, human respiratory syncytial virus

25 (RSV) A and B and human immunodeficiency virus 1 (HIV1). We also considered viruses targeted

26 by vaccinations including poliovirus (PoV), mumps virus (MuV), rubella virus (RuV), papilloma

27 virus (PaV) and rotavirus A (RTVA). Among the bacteria we considered bacille Calmette-Guérin

28 (BCG), Bordetella pertussis (Bpe), Corynebacterium diphtheriae (Cdi), Clostridium tetani (Cte),

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1 Haemophilus influenzae (Hin), Neisseria meningitidis (serogroup B) and Streptococcus pneumoniae

2 (Spn), which are all targeted by vaccinations. We found 595 unique peptides in the analyzed

3 proteomes matching 551 peptides from SARS-CoV-2, indicating that cross-reactivity with SARS-

4 CoV-2 is quite private. The complete data is provided in Supplementary Dataset 1 and in Table 2 we

5 summarize the results. Overall, the number of SARS-CoV-2 peptide matches as well as that of

6 potential cross-reactive B and T cell epitopes correlated with the size of the proteomes (Table 2).

7 8 Table 2. Summary of potential cross-reactivity immunity to SARS-CoV-2 from selected pathogens SARS- Peptide B (2) CD8 T (3) CD4 T (4) Vaccine (5) Hits(1) Mumps virus (MuV) 2 1 0 0 Y Measles virus (MeV) 0 0 0 0 Y Rubella Virus (RuV) 0 0 0 0 Y Hepatitis B virus (HBV) 1 1 0 0 Y Varicella Zoster Virus (VZV) 4 1 2 0 Y Polio Virus (PoV) 0 0 0 0 Y Pappiloma Virus (PaV) 2 1 1 1 Y Rotavirus A (RTVA) 0 0 0 0 Y Influenza A virus (IAV) 0 0 0 0 Y Influenza B virus (IBV) 0 0 0 0 Y Herpes simplex virus 1 (HSV1) 0 0 0 0 N Herpes simplex virus 2 (HSV2) 2 1 0 0 N Epstein-Barr virus (EBV) 9 3 2 1 N human cytomegalovirus (HCMV) 1 0 0 0 N human rhinovirus A (HRVA) 1 1 0 0 N human rhinovirus B (HRVB) 0 0 0 0 N human rhinovirus C (HRVC) 0 0 0 0 N Human Immunodeficiency 1 (HIV1) 0 0 0 0 N Bacille Calmette-Guérin (BCG) 120 41 21 11 Y Bordetella pertussis (Bpe) 111 36 18 12 Y Corynebacterium diphtheriae (Cdi) 83 33 14 5 Y Clostridium tetani (Cte) 85 34 17 7 Y Haemophilus influenzae (Hin) 53 16 6 5 Y Neisseria meningitides (Nme) 60 23 9 3 Y Streptococcus pneumoniae (Spn) 61 19 13 6 Y 9 1 Number of peptides in the relevant pathogen with ≥ 8 residues and identity ≥ 80 % with SARS-CoV-2 2 10 Peptide hits with B cell reactivity above 0.4 (predicted as cross-reactive B-cell epitopes). 3 Peptides predicted as 11 cross-reactive CD8 T cell epitopes. 4 Peptides predicted as cross-reactive CD4 T cell epitopes. 5 Whether these 12 pathogens are subject to vaccinations. Whole dataset available in Supplementary Dataset 1. 13

14 Cross-reactive immunity to SARS-CoV-2 from prevalent viruses and viruses targeted by

15 vaccinations

17 A recent study have detected SARS-CoV-2–reactive CD4 T cells in unexposed individuals,

18 suggesting cross-reactive T cell recognition between circulating ‘common cold’ coronaviruses and

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1 SARS-CoV-2 [20]. In the virus included in this study, there are only 22 SARS-CoV-2 peptide

2 matches, including 9 peptides with predicted B-cell/antibody reactivity and 5 with predicted T cell

3 cross-reactivity (Table 2). There are 2 SARS-CoV-2 peptides matching with MuV and VZV which

4 map in the Spike protein, the target of protective neutralizing antibodies [21](Table 3). However,

5 these peptides have no predicted B-cell reactivity and more importantly do not map in accessible

6 regions (data not shown). Of the 5 T cell cross-reactive epitopes, two are present in EBV; one of

7 them (APSASAPF) is restricted by two HLA I molecules (B*07:02 and B*35:01) and the other

8 (DLLLDASVEI) by one HLA I (A*02:01) and two HLAII (HLA-DRB1*03:01 and HLA-

9 DRB3*01:01) molecules. No vaccine is available for EBV and these cross-reactive epitopes may be

10 drivers of protective or pathological immune responses in the individual expressing the noted HLA

11 molecules. The other 3 potential cross-reactive T cell epitopes are found in two viruses targeted by

12 vaccinations (Table 3). There are two CD8 T cell epitopes in VZV, one restricted by B*35:01 and

13 another by B*08:01 and additional epitope in PaV that can be presented by class I (A*02:01) and

14 class II (DRB1*01:01, HLA-DRB1*03:01, HLA-DRB1*09:01) HLA molecules (Table 3). PaV

15 vaccines consist of recombinant L1 proteins [22] while the potentially cross-reactive PaV epitope

16 maps in the E1 protein (Table 3). Thereby, PaV infection but not the vaccine can elicit T cell cross-

17 reactivity to SARS-Cov-2. Overall, we can conclude that the selected viruses and particularly those

18 targeted by vaccinations are poor sources of immune cross-reactivity to SARS-CoV-2 (Table 2 and

19 Table 3). Thereby, we can discard that current pediatric vaccinations for viral diseases protect from

20 SARS-CoV-2 infection, as recently suggested for RuV vaccine [23]. Such suggestion was based on

21 the distant homology observed between SARS-CoV-2 NS3P and Rubella virus p150 proteins but not

22 a single peptide is shared between SARS-CoV-2 and RuV.

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YP_009725304 QMYKQARS NP_040156.1 SEDKLAKV 87.5 1.0 |NSP8-69-83| EDKRAKV |VZV| NP NP HLA-DRB1*01:01, YP_009725297 NEKTHVQLS YP_009163893.1 VQLSLPPLLV 80 -0.7 HLA-A*02:01 HLA-DRB1*03:01, |LP-9-23| LPVLQV |PaV| HLA-DRB1*09:01 YP_009725308 YSTLQGPPG YP_009163893.1 GPPDTGKSLF 80 2.4 |HEL-277-291| TGKSHF |PaV| NP NP YP_009725308 YSTLQGPPG YP_009505608.1 IHGPPGTGKS 80 2.1 |HEL-277-291| TGKSHF |HRVA| NP NP YP_009724391 QIHTIDGSSG YP_009173870.1 SSGTVNPV 87.5 1.1 NP NP |ORF3a-245-259| VVNPV |HBV| YP_009725299 ISSFKWDLT YP_009137182.1 LTAAGLVA 87.5 -0.5 |NSP3-1493-1507| AFGLVA |HSV2| NP NP YP_009725298 MKCDHCGE YP_009137214.1 EPSWQTGD 87.5 1.6 |NSP2-141-155| TSWQTGD |HSV2| NP NP YP_009725303 TSVVLLSVL YP_081506.1 LLSALQQL 87.5 -1.2 |NSP7-9-23| QQLRVE |HCMV| NP NP YP_009724397 WPQIAQFAP YP_401663.1 HLA-B*07:02, APSASAPF 87.5 1.4 NP |NP-301-315| SASAFF |EBV| HLA-B*35:01 YP_009725299 IKKPNELSR YP_401644.1 ELSPVLGL 87.5 -0.4 |NSP3-1289-1303| VLGLKT |EBV| NP NP YP_009725302 CLLNRYFRL YP_401712.1 FRLTGGVY 87.5 -0.3 |NSP6-229-243| TLGVYD |EBV| NP NP YP_009725306 LCTHTGTGQ YP_401662.1 TSQAITVT 87.5 0.5 NP NP |NSP10-45-59| AITVTP |EBV| YP_009725307 PCGTGTSTD YP_401694.1 GTGTSTGV 87.5 1.5 NP NP |POL-21-35| VVYRAF |EBV| YP_009725307 VDTDLTKPY YP_401667.1 TVPYIKWD 87.5 -0.1 |POL-257-271| IKWDLL |EBV| NP NP YP_009725308| VPQEHYVRI YP_401712.1 VRITGLIP 87.5 -0.8 HEL-241-255 TGLYPT |EBV| NP NP YP_009725310 HLLIGLAKR YP_401688.1 LKKRFKESYF 80 -0.3 NP NP |RNASE-249-263| FKESPF |EBV| YP_009725310 SVIDLLLDDF YP_401687.1 HLA-DRB1*03:01, DLLLDASVEI 80 -0.8 HLA-A*02:01 |RNASE-293-307| VEIIK |EBV| HLA-DRB3*01:01 1 1Accession and antigen source of SARS-Cov-2 peptide. 2 Sequence of peptide used in BLAST searches. 2 3Accession and source virus of BLAST hit. 4 Sequence of peptide hit 5 Percentage of identify between peptide 3 hit and equivalent SARS-CoV-2 peptide. 6 B cell/Antibody reactivity (peptide hits with B above 0.4 were 4 considered as cross-reactive B cell epitopes). 7 CD8 T cell cross-reactivity given by the HLA I molecules 5 predicted to bind both the peptide hit and the equivalent SARS-CoV-2 peptide. 8 CD4 T cell cross-reactivity 6 given by the HLA II molecules predicted to bind both the peptide hit and the equivalent SARS-CoV-2 peptide. 7 NP: None Predicted. 8

9 Cross-reactive immunity to SARS-CoV-2 from bacteria targeted by vaccinations

11 In contrast to viruses, the selected bacterial proteomes are considerable sources of cross-reactive

12 immunity to SARS-CoV-2, correlating with their large proteomes (Table 2). However, the potential

13 immune cross-reactivity rising from these bacteria shall be considered relevant. The match between

14 SARS-CoV-2 and bacteria peptidomes is quite private; only 28 SARS-CoV-2 peptides out of 535

15 have a match with more than one bacterial proteome. Moreover, 88% of SARS-CoV-2 peptide

16 matches with bacteria are absent in human or have an identity under that with bacteria (see

17 Supplementary Dataset 1). The majority (68 %) of cross-reactive SARS-CoV-2 peptides with

18 bacteria do also match the human microbiome (44 % with higher identity)(see Supplementary Dataset

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1 1). This finding might look trivial but it is actually very interesting. It has been a noted that

2 maintaining a diverse microbiota is essential for a competent immunity system [24,25]. Loss of

3 microbiota diversity is associated with many diseases, it occurs in the elderly and

4 immunocompromised subjects and it can increase susceptibility to viral infections [26]. How a

5 diverse microbiota helps to fight viral infections is unclear but sure it can increase the chance for

6 cross-reactive adaptive immunity.

8 The proteomes of BCG, B. pertussis, C. diphtheriae, C. tetani, H. influenzae, N. meningitidis and S.

9 pneumoniae, contain numerous potentially cross-reactive epitopes to wonder whether vaccination

10 against these bacteria could elicit protective heterologous immunity against SARS-CoV-2 (Table 2).

11 Such possibility has already been proposed for BCG [27,28,29] but through a different mechanism.

12 BCG is a live attenuated strain of Mycobacterium bovis used to prevent tuberculosis (TB) [30], which

13 is known to confer heterologous protective immunity to unrelated pathogens, including viruses, by

14 inducing trained immunity [31,32]. Heterologous trained immunity is antigen non-specific and

15 involves functional reprogramming of innate immune cells [33]. It was the observation that there are

16 less COVID-19 cases and fatalities in countries implementing BCG vaccination that led to postulate

17 that trained immunity resulting from BCG vaccination could confer some protection against SARS-

18 CoV-2 [27,28,29]. Although we fully acknowledge the concept of trained immunity our results also

19 support that, if any, long-term protection against SARS-CoV-2 induced by BCG is most likely due to

20 the presence of cross-reactive epitopes. We, however, find arguably that current BCG vaccinations are

21 responsible for long-term protecting against SARS-Cov-2.

23 BCG is only given once at birth and long-term protection against any pathogen generally requires

24 repeated antigen re-exposure to maintain memory T and B cells [34]. Moreover, BCG vaccination is

25 only included in some countries while children and teenagers are largely unaffected by SARS-CoV-2

26 worldwide. In line with these arguments, a recent epidemiological study has discarded that BCG

27 vaccination in childhood has a protective effect against COVID-19 in adulthood [35]. Therefore, we

28 next turned to analyze if immune cross-reactivity to SARS-Cov-2 from vaccines to C. diphtheriae, B.

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1 pertusis, C. tetani, H. influenzae, N. meningitidis and S. pneumoniae is what keeps children and

2 young people safe from COVID-19.

4 Cross-reactive immunity to SARS-CoV-2 from bacterial vaccines: DTP and MenB

6 Pediatric vaccines for bacterial disease differ widely and we first investigated their composition.

7 Vaccines for H. influenzae (Hib), S. pneumoniae (PCV) and N. meningitides serotypes A, C, W and

8 Y (MenC and MenACWY) consist of bacteria cell wall polysaccharides, alone or conjugated with

9 tetatus and/or diphteria toxoids [36,37,38,39]. In contrast, vaccines for N. meningitides serotype B

10 (MenB) consist of surface proteins from N. meningitides [14]. Diphteria (D) and tetanus (T) vaccines

11 contain inactivated toxins produced by the bacteria (toxoids) but in addition include a large array of

12 proteins as shown by proteomics studies, which can be immunogenic [13,40]. D and T antigens are

13 generally combined with pertussis (P) antigens as a combination DTP vaccine, which is available in

14 two main formulations: DTaP and DTwP. DTaP contains selected P antigens without cells (acelular

15 pertusis, aP) and DTwP includes inactivated whole pertussis bacteria (wP)[41].

17 After considering the nature of bacterial vaccines, we discarded conjugate and polysaccharides

18 vaccines and sought for potential sources of cross-reactive immunity in antigens identified by

19 proteomics in DTa/wP and MenB vaccines. D and T antigens can vary between different vaccines

20 and here we considered the sum of all those reported elsewhere in [12,13,40]. Our results,

21 summarized in Table 4, indicate that combination DTP vaccines are significant sources of B and T

22 cell cross-reactivity to SARS-CoV-2, while such cross-reactivity is small from MenB vaccine. In

23 DTaP, P antigens do not contribute to increase the cross-reactive immunity provided by D and T

24 antigens, but in DTwP, wP provide as much cross-reactive immunity as D and T antigens together

25 (Table 4).

26 27 Table 4. Summary of potential cross-reactive immunity to SARS-CoV-2 from selected vaccine 28 antigens Vaccine SARS-Peptide Proteins B (2) CD8 T (3) CD4 T (4) Antigens Hits(1)

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D 340 24 6 5 2 T 601 28 13 8 2 aP 25 3 1 1 0 wP 1852 67 23 10 5 MenB 267 10 3 2 1 1 1 Number of peptides in the relevant antigens with ≥ 8 residues and identity ≥ 80 % with SARS-Cov-2. 2 Peptide 2 hits with B cell reactivity above 0.4 (predicted as cross-reactive B-cell epitopes). 3 Peptides predicted as cross- 3 reactive CD8 T cell epitopes. 4 Peptides predicted as cross-reactive CD4 T cell epitopes. 4

5 It is interesting to note that combination DTP vaccines, particularly DTwP, appear to be good

6 inducers of cross-reactive CD8 T cells, which are key to clear viral infections by killing infected cells.

7 The elicitation of virus cross-reactive CD8 T cells with bacterial antigens can occur through cross-

8 presentation. This process enables antigen-presenting cells to display endocytosed antigens in the

9 context of HLA I molecules and prime CD8 T cells with anti-viral activity [42]. Some cross-reactive

10 T cell epitopes in DTP and MenB vaccines can be presented by HLA I and HLA II molecules,

11 eliciting both, CD8 and CD4 T cell responses (Table 5). Moreover, many of the cross-reactive CD8

12 and CD4 T cell epitopes can be presented by various HLA I and HLA II molecules, respectively. T

13 cell epitopes are only immunogenic in those individual expressing the HLA molecules that restrict the

14 responses. With our data, we computed that the percentage of the world population that will have

15 cross-reactive CD8 T cell responses to SARS-CoV-2 from MenB, DTaP and DTwP vaccinations will

16 be 46.54%, 65.59% and 85.79 %, respectively. Moreover, the percentage of the world population that

17 will have cross-reactive CD8 and CD4 T cells to SARS-CoV-2 from MenB, DTaP and DTwP

18 vaccines will be 70.9%, 77.47% and 94.67%, respectively. From these data, we can confirm that

19 combination DTP vaccines, and particularly DTwP, would be able to elicit cross-reactive T cell

20 responses against SARS-CoV-2 in most individuals.

22 Table 5. Potential cross-reactive T cell epitopes from DTP and MenB vaccines SARS-Cov-2 SARS-Cov-2 HIT ACN (4) ID % (6) (7) (8) (1) query (3) Vaccine (5) HIT SEQ CD8 T CD4 T Antigen (2) sequence HLA-DRB1*03:01, HLA-A*03:01, HLA-DRB1*07:01, YP_009724394| INLIIKNLSKS FTSA_ HLA-A*11:01, HLA-DRB1*08:02, MenB 81.8 NLITKDLSKSL ORF6-33-47 LTEN NEIMB HLA-B*07:02, HLA-DRB1*12:01, HLA-B*08:01 HLA-DRB1*13:02, HLA-DRB3*01:01 YP_009724392| NIVNVSLVK Q9K1E8_ HLA-A*23:01, MenB 80.0 VNVSLVDLSF NP ENV-45-59 PSFYVY NEIMB HLA-B*35:01 YP_009725311| LPTGTLLVDS Q6NGY6_ D 80.0 LLVDADLTDF HLA-A*01:01, HLA-DRB1*03:01,

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2ORMT-89-103 DLNDF CORDI (DTaP/wP) HLA-B*35:01 HLA-DRB3*01:01 YP_009725298| FVFPLNSIIKT Q6NJR6_ D HLA-A*03:01, HLA-DRB1*03:01, 88.9 SIIKTIQDR NSP2-93-107 IQPR CORDI (DTaP/wP) HLA-A*11:01 HLA-DRB4*01:01 HLA-B*40:01, YP_009724390| SSANNCTFE Q6NIW5_ D 87.5 FEYVSQNF HLA-B*44:02, NP SPIKE-161-175 YVSQPF CORDI (DTaP/wP) HLA-B*44:03 HLA-B*40:01, YP_009725309| AENVTGLFK Q6NFL4_ D 87.5 AENVTGFF HLA-B*44:02, NP 35EXON-1-15 DCSKVI CORDI (DTaP/wP) HLA-B*44:03 YP_009725307| RVYANLGER SYI_ D 87.5 EGVRQALL HLA-B*08:01 NP POL-173-187 VRQALL CORDI (DTaP/wP) YP_009725309| HLA-B*35:01, CFVKRVDWT Q899B2_ T 35EXON-285- 80.0 LKRVDWDIEY HLA-B*44:02, HLA-DRB3*01:01 IEYPII CLOTE (DTaP/wP) 299 HLA-B*44:03 HLA-B*08:01, YP_009725298| YELQTPFEIK Q894R8_ T 87.5 EIKKAKKF HLA-B*44:02, NP NSP2-69-83 LAKKF CLOTE (DTaP/wP) HLA-B*44:03 YP_009725297| MVELVAELE Q891V6_ T HLA-A*01:01, 80.0 LVAILEGIRY NP LP-85-99 GIQYGR CLOTE (DTaP/wP) HLA-B*35:01 YP_009725309| RVDWTIEYPI Q899B2_ T HLA-A*01:01, 35EXON-289- 87.5 RVDWDIEY NP IGDEL CLOTE (DTaP/wP) HLA-B*35:01 303 YP_009725308| YSTLQGPPG Q891B9_ T HLA-A*03:01, 80.0 LVGPPGTGKT NP HEL-277-291 TGKSHF CLOTE (DTaP/wP) HLA-A*11:01 YP_009724390| VFLHVTYVP Q899V7_ T SPIKE-1061- 80.0 TNVHAQEKNF HLA-B*35:01 NP AQEKNF CLOTE (DTaP/wP) 1075 YP_009725308| YSTLQGPPG Q895L6 T 80.0 LYGPPGTGKT HLA-A*03:01 NP HEL-277-291 TGKSHF _CLOTE (DTaP/wP) YP_009725308| FAAETLKAT Q899L8_ T 88.9 KATEETVKL HLA-B*35:01 NP HEL-133-147 EETFKL CLOTE (DTaP/wP) YP_009725307| GNCDTLKEIL Q899S9_ T HLA-DRB1*04:05, 87.5 LKEILVNYN NP POL-137-151 VTYNC CLOTE (DTaP/wP) HLA-DRB1*12:01 YP_009725308| FNVAITRAK Q7VX10_ wP/aP 87.5 TGAKVGIL HLA-B*08:01 NP HEL-561-575 VGILCI BORPE (DTaP/wP) HLA-DRB1*01:01, YP_009724390| RVVVLSFEL Q7VSF2_ wP HLA-DRB1*04:01, 80.0 SFELAEAPAT HLA-B*40:01 SPIKE-509-523 LHAPAT BORPE (DTwP) HLA-DRB1*04:05, HLA-DRB1*09:01 YP_009725299| YLATALLTL Q7VWJ0_ wP 80.0 ALLTLQQLHL HLA-A*02:01 HLA-DRB4*01:01 NSP3-857-871 QQIELK BORPE (DTwP) YP_009724397| AALALLLLD Q7VSK8_ wP HLA-A*03:01, 80.0 ARLALLPLDR NP NP-217-231 RLNQLE BORPE (DTwP) HLA-A*11:01 YP_009725298| YELQTPFEIK Q7VVM6 wP HLA-B*07:02, 87.5 SPFEIKLA NP NSP2-69-83 LAKKF BORPE (DTwP) HLA-B*35:01 YP_009724397| RMAGNGGD Q7VUJ1_ wP QAGQGGDAA 80.0 HLA-B*07:02 NP NP-209-223 AALALLL _BORPE (DTwP) L YP_009724390| YNYLYRLFR Q7VZJ7 wP 87.5 RLFRKSLL HLA-B*08:01 NP SPIKE-449-463 KSNLKP _BORPE (DTwP) YP_009725302| WLDMVDTS Q7VXB3_ wP 87.5 SLSGGKLK HLA-A*03:01 NP NSP6-97-111 LSGFKLK BORPE (DTwP) YP_009725299| HGGGVAGA Q7VVD1_ wP 80.0 GGVAGALFAA HLA-A*02:01 NP NSP3-249-263 LNKATNN BORPE (DTwP) YP_009725299| VEEAKTVLK RL19_ wP 80.0 KLVLKKAKSA HLA-B*08:01 NP NSP3-521-535 KCKSAF BORPE (DTwP) HLA-DRB1*01:01, YP_009724391. LPFGWLIVG Q7VZ84_ wP 88.9 LIVGLALLA NP HLA-DRB1*08:02, 1|ORF3a-41-55 VALLAV BORPE (DTwP) HLA-DRB1*15:01 YP_009724392. NIVNVSLVK Q7VS52_ wP HLA-DRB1*03:01, 80.0 VVIVSLVKPS NP 1|ENV-45-59 PSFYVY BORPE (DTwP) HLA-DRB1*08:02 YP_009725307| LRKHFSMMI PTLC_ wP HLA-DRB1*04:05, 80.0 HFSMMILGAD NP POL-749-763 LSDDAV BORPE (DTwP) HLA-DRB4*01:01 1 1Accession and antigen source of SARS-CoV-2 peptide. 2 Sequence of peptide used in BLAST searches. 2 3Accession of BLAST hit bacterial antigen. 4 Vaccine incorporating antigen. All vaccines with D or T antigens 3 are labeled as DTa/wP. 5 Percentage of identify of peptide hit to equivalent SARS-CoV-2 peptide. 6 Sequence of

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1 bacterial peptide hit. 7 CD8 T cell cross-reactivity given by the HLA I molecules predicted to bind both the hit 2 peptide and the equivalent SARS-CoV-2 peptide. 8 CD4 T cell cross-reactivity given by the HLA II molecules 3 predicted to bind both the peptide hit and the equivalent SARS-CoV-2 peptide. NP: None Predicted. 4

5 Elicitation of effective cross-reactive T cell responses to SARS-Co-V2, particularly CD8 T cell

6 responses, would allow the host to clear the virus quickly and exhibit milder courses of COVID-19.

7 However, children appear to be largely unaffected by the virus, which is consistent with having

8 protective antibody immunity blocking and limiting viral infection. Interestingly, such protective

9 immunity could also result from cross-reactive antibodies elicited by combination DTP vaccines.

10 Thus, we found 16 SARS-CoV-2 peptide matches with DTP antigens, mapping in ectodomains of

11 virion surface antigens, and of those 14 are in SARS-Cov-2 Spike protein (Table 6). None of the

12 SARS-CoV-2 peptide matches mapping in virion surface antigens are from aP antigens, while 11 are

13 from wP, highlighting the superiority of DTwP vaccines in eliciting potentially protective cross-

14 reactive immunity to SARS-Co-V2. It is worth noting that some SARS-CoV-2 peptide matches such

15 as FEYVSQPF are not predicted as B-cell epitopes (B < 0.4) but yet could be readily recognized by

16 antibodies as shown by the computed solvent accessibilities (Table 6). B cell epitope predictions

17 methods are in general quite unreliable and actual solvent accessibilities values are better measures of

18 potential B cell reactivity.

20 Table 6. Potential cross-reactive B cell epitopes from DTP and MenB vaccine antigens SARS-CoV-2 (1) HIT ACN Vaccine SARS-Cov-2 Virion Acc (%) HIT PEP (5) ID %(6) B (8) Surface Antigen (2) (3) Peptide (4) Surface (7) (9) YP_009724390 ATPG_ wP VFLVLLPL VFLRLLPL 87.5 N -2.4 NA SPIKE-1-15 BORPE (DTwP) YP_009724390 Q6NIW5_ D FEYVSQPF FEYVSQNF 87.5 Y -0.3 62.50 SPIKE-161-175 CORDI (DTa/wP) YP_009724390 Q7VZN3_ wP QTLLALHR QTLLATHR 87.5 Y -0.7 9.20 SPIKE-233-247 BORPE (DTwP) YP_009724390 Q7VVR9_ wP SSSGWTAGAAA QSSGWTAGADA 81.8 Y 1.3 19.10 SPIKE-253-267 BORPE (DTwP) YP_009724390 Q7VZJ7_ wP RLFRKSNL RLFRKSLL 87.5 Y -1.4 66.00 SPIKE-449-463 BORPE (DTwP) YP_009724390 Q7VSF2_ wP SFELLHAPAT SFELAEAPAT 80.0 Y 0.6 44.71 SPIKE-509-523 BORPE (DTwP) YP_009724390 SMG_ wP ELLHAPAT ELAHAPAT 87.5 Y 0.6 51.73 SPIKE-509-523 BORPE (DTwP) YP_009724390 Q7VX63_ wP SVAYSNNS SVAYSNNS 100.0 Y 0.7 84.18 SPIKE-701-715 BORPE (DTwP) YP_009724390 Q7VSI7_ wP IPFAMQMA IPFTMQMA 87.5 Y -0.7 48.84 SPIKE-893-907 BORPE (DTwP) YP_009724390 Q6NG46 D ALNTLVKQ ALNGLVKQ 87.5 Y -0.6 32.18 SPIKE-953-967 _CORDI (DTa/wP) YP_00972439 Q7VSP7_ wP DRLITGRL DRLIEGRL 87.5 Y -0.5 36.80

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SPIKE-989-1003 BORPE (DTwP) YP_009724390 Q899V7_ wP TYVPAQEKNF TNVHAQEKNF 80.0 Y 1.1 26.87 SPIKE-1061-1075 CLOTE (DTa/wP) YP_009724390 CARA_ D EGVFVSNG DGVFVSNG 87.5 Y -0.1 22.30 SPIKE-1089-1103 CORDI (DTa/wP) YP_009724390 Q898W3_ T EELDKYFK EKLDKYFK 87.5 Y -0.2 35.95 SPIKE-1145-1159 CLOTE (DTa/wP) YP_009724390 SYFB_ wP IAGLIAIV IAGLVAIV 87.5 Y -1.5 2.70 SPIKE-1221-1235 BORPE (DTwP) YP_009724393 CH60_ wP TVEELKKL AVEELKKL 87.5 Y -0.3 45.90 MP-5-19 BORPE (DTwP) YP_009724393 Q893U5_ T VEELKKLL VEELKKEL 87.5 Y -0.1 23.63 MP-5-19 CLOTE (DTa/wP) YP_009724393 Q897F9_ T IKDLPKEI IKDNPKEI 87.5 N 1.3 NA MP-157-171 CLOTE (DTa/wP) YP_009724392 Q7VSN6_ wP SVLLFLAF SVLKFLAF 87.5 N -2.0 NA ENV-9-23 BORPE (DTwP) YP_009724392 Q7VS52_ wP IVNVSLVKPS VVIVSLVKPS 80.0 N -1.0 NA ENV-45-59 BORPE (DTwP) YP_009724392 GLPK1_ T VKPSFYVY VKPSSYVY 87.5 N 1.4 NA ENV-45-59 CLOTE (DTa/wP) YP_009724392 Q9K1E8_N MenB VNVSLVKPSF VNVSLVDLSF 80.0 N 0.0 NA ENV-45-59 EIMB 1 1SARS-Cov-2 surface antigen. 2Accession of antigens with potential cross-reactivity. 3 Vaccine antigen. For D, 2 T, aP and wP antigens we show in parenthesis the vaccine incorporating that antigen. D and T antigens are 3 noted to be in DTaP and DTwP vaccines (DTa/wP) 4 SARS-Cov-2 peptide sequence. 5 Peptide hit sequence 4 with identity to SARS-Cov-2 peptide.6 Sequence Identity (%) between SARS-Cov-2 and hit peptides. 7 5 Whether the peptide map in a region of the antigen located at the virion surface. 8 B cell/Antibody reactivity 6 (peptide hits with B ≥ 0.4 are predicted as cross-reactive B-cell epitopes). 9 Solvent accessibility of SARS-CoV- 7 2 peptide in percentage computed upon residue relative solvent accessibilities from the relevant 3D-structures 8 (details in Methods). 9

10 SARS-CoV-2 entry in the host cells is facilitated by angiotensin-converting enzyme 2 (ACE2), which

11 is engaged by the receptor binding domain (RBD) of the Spike protein [43,44]. Antibodies that

12 interfere with such interaction have been shown to be neutralizing and block viral entry [21].

13 Interestingly, two of the potential cross-reactive B-cell epitopes (RLFRKSNL and SFELLHAPAT)

14 from wP antigens map in solvent exposed regions of the spike RBD domain (Fig.1), indicating that

15 they can be neutralizing. There is also a cross-reactive B cell epitope (FEYVSQPF) from a D antigen,

16 which is in close proximity (15-20 Å) to the RBD domain. Antibodies targeting this epitope will, by

17 steric hindrance, block viral engagement with ACE2. Other accessible B-cell epitopes from D, T and

18 wP antigens could also lead to the same effect (Table 6 and Fig. 1). Antibody blocking of ACE2

19 interaction with Spike by steric hindrance is enhanced by the fact that SARS-CoV-2 Spike protein is a

20 trimer.

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1 2 Figure 1. Cross-reactive B cell epitopes tagging SARS-CoV-2 Spike protein. Figure shows a surface 3 rendering of the tertiary structure of the trimeric SARS-CoV-2 Spike protein in the open state with cross- 4 reactive B cell epitopes in red. The Spike RBD is shown in green and in blue ACE2. We show the location and 5 sequence of three B cell epitopes that are in RBD or nearby. These B cell epitopes can be the targets of 6 neutralizing antibodies. 7

8 9 We realize that we did not analyze if the potential cross-reactive B-cell epitopes in SARS-CoV-2 are

10 also accessible in the source proteins. Although such analysis can be of interest, we found it

11 unnecessary since our approach was aimed to identify continuous/linear B cell epitopes and not-

12 conformational B-cell epitopes. Actually, all identified cross-reactive B-cell epitopes in SARS-CoV-2

13 Spike protein with solvent accessibility above 33% map in loop regions. Moreover, it is worth noting

14 that extracellular proteases can degrade antigens as well as immune cells such as neutrophils, which

15 phagocyte antigens and release them semi-degraded. Thus, during the course of immune response

16 there are all sort of antigen fragments (intracellular, extracellular, accessible, buried etc) and

17 antibodies against them are generated, as shown by B-cell epitope mapping analysis [45,46,47]. Of all

18 the antibodies generated against a given pathogen, only those recognizing accessible B-cell epitopes

19 in accessible antigens may be protective against that particular pathogen. However, our results

20 support that all the remaining antibodies can also be still useful for providing cross-reactive

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1 immunity.

3 DTP vaccination and COVID-19 epidemiology

5 Our data indicates that DTP vaccines can elicit ample T cell and B cell cross-reactive immunity

6 against SARS-CoV-2. Likewise, MenB vaccines can also induce some substantial cross-reactive T

7 cell immunity against SARS-CoV-2. However, MenB vaccines are unlikely responsible for the

8 observed resilient of children to SARS-CoV-2 worldwide; MenB vaccines have been introduced very

9 recently, in the last decade, and not everywhere [48,49]. In contrast, combination DTP vaccines are

10 included in every single vaccination program since the 1940-50 [41]. During infancy, children

11 receive 3-4 dose (2, 3, 4, and 11 months of age) of either DTaP or DTwP, often in combination with

12 inactivated poliovirus, conjugated Hib and recombinant antigens from HBV. Children also receive a

13 pediatric DTaP booster vaccination at 4-6 years of age and a Tdap booster vaccination with lower

14 antigenic load at 9-14 years of age. Moreover, pregnant women are also recommended to have a

15 Tdap shot (https://www.who.int/topics/immunization/en/). Repeated vaccinations with DTP will

16 therefore support that children and the youngest could be protected against SARS-CoV-2 through

17 cross-reactive immunity elicited by these vaccines. Cross-reactive immunity elicited by DTP

18 vaccines will eventually wane over time explaining why COVID-19 cases and severity increases with

19 age.

21 The current vaccination trend has favored the use DTaP instead of DTwP vaccines [41]. In Europe

22 most countries use combination DTaP vaccines but some still use combination DTwP vaccines.

23 Taken in consideration that the P component in DTaP vaccines has little contribution to the cross-

24 reactive immunity SARS-CoV-2, we can also conclude that cross-reactive immunity from the D and

25 T components is likely what protects children against COVID-19 worldwide. This protection may be

26 enhanced by conjugated vaccines using D and T toxoids, such as Hib and PCV [36,37,39,50].

27 However, our data also indicate that cross-reactive immunity to SARS-Cov-2 from the P component

28 in combination DTwP vaccines rivals that of D and T antigens together, suggesting that DTwP

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1 vaccines may confer more protection against SARS-Cov-2. Interestingly, COVID-19 deaths and

2 cases per million in Europe and Asian countries of the former URSS (Table S1) are significantly

3 lower (p < 0.005) in those countries implementing DTwP vaccines (Fig. 2). Median deaths and cases

4 per million in countries with wP vaccines are 13 and 451, while these same figures in countries with

5 aP vaccines are 52 and 1387.

8 Figure 2. COVID-19 cases and deaths in Europe with regard to the P component in DTP vaccines. Figure 9 shows a boxplot representation of COVID-19 cases (A) and deaths (B) per million in Europe including Asian 10 countries from former URSS with regard to the inclusion of aP or wP in combination DTP vaccines. Non- 11 parametric Kruskal-Wallis test indicates that both deaths and cases are significant lower in countries with DTwP 12 vaccines (p < 0.005). 13

14 Epidemiological data show that adolescents primed with DTaP during infancy are also less protected

15 against clinical pertussis than DTwP-primed children [51]. Priming with DTwP or DTaP combination

16 vaccines during infancy actually determine latter immune memory responses at preadolescent age to

17 all DTaP antigens, with wP-priming resulting in a beneficial Th1-dominated response [52]. Most

18 likely this Th1-dominated response is also beneficial against SARS-CoV-2.

20 CONCLUSION

22 Our findings indicate that cross-reactive immunity elicited by DT antigens in combination DTP

23 vaccines is likely keeping children and the youngest safe from COVID-19 worldwide. Cross-reactive

24 immunity elicited by these vaccines surely wanes over time explaining why COVID-19 cases and

25 severity increases with age. The global health crisis caused by COVID-19 has prompted many efforts

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1 to develop a specific vaccine against SARS-CoV-2, which if successful will take a long time to

2 achieve. However, we need a vaccine for SARS-CoV-2 today and our results support that DTP

3 vaccinations, and in particular DTwP vaccinations, could protect the general population against

4 COVID-19 through cross-reactive immunity. Given the heterogenicity of DTP vaccines, our results

5 also suggest that COVID-19 death rates and severity in different countries may be linked to

6 differences in the composition of DTP vaccines, vaccination regimes and initiation of DTP

7 vaccination programs.

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1 References

2 3 1. She J, Jiang J, Ye L, Hu L, Bai C, et al. (2020) 2019 novel coronavirus of pneumonia in Wuhan, 4 China: emerging attack and management strategies. Clin Transl Med 9: 19. doi: 5 10.1186/s40169-40020-00271-z. 6 2. Huang C, Wang Y, Li X, Ren L, Zhao J, et al. (2020) Clinical features of patients infected with 7 2019 novel coronavirus in Wuhan, China. Lancet 395: 497-506. doi: 410.1016/S0140- 8 6736(1020)30183-30185. Epub 32020 Jan 30124. 9 3. Viruses CSGotICoTo (2020) The species Severe acute respiratory syndrome-related coronavirus: 10 classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5: 536-544. doi: 11 510.1038/s41564-41020-40695-z. Epub 42020 Mar 41562. 12 4. Rodriguez-Morales AJ, Cardona-Ospina JA, Guti√©rrez-Ocampo E, Villamizar-Pe√±a R, Holguin- 13 Rivera Y, et al. (2020) Clinical, laboratory and imaging features of COVID-19: A systematic 14 review and meta-analysis. Travel Med Infect Dis 34:101623.: 10.1016/j.tmaid.2020.101623. 15 Epub 102020 Mar 101613. 16 5. Li R, Tian J, Yang F, Lv L, Yu J, et al. (2020) Clinical characteristics of 225 patients with COVID- 17 19 in a tertiary Hospital near Wuhan, China. J Clin Virol 127:104363.: 18 10.1016/j.jcv.2020.104363. Epub 102020 Apr 104310. 19 6. Ge H, Wang X, Yuan X, Xiao G, Wang C, et al. (2020) The epidemiology and clinical information 20 about COVID-19. Eur J Clin Microbiol Infect Dis 39: 1011-1019. doi: 1010.1007/s10096- 21 10020-03874-z. Epub 12020 Apr 10014. 22 7. Fulton RB, Varga SM (2009) Effects of aging on the adaptive immune response to respiratory virus 23 infections. Aging health 5: 775. doi: 710.2217/ahe.2209.2269. 24 8. Zhao M (2020) Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine 25 and anti-IL-6 monoclonal antibodies. Int J Antimicrob Agents 55: 105982. doi: 26 105910.101016/j.ijantimicag.102020.105982. Epub 102020 Apr 105916. 27 9. Agrawal B (2019) Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to 28 Infections. Front Immunol 10:2631.: 10.3389/fimmu.2019.02631. eCollection 02019. 29 10. Welsh RM, Fujinami RS (2007) Pathogenic epitopes, heterologous immunity and vaccine design. 30 Nat Rev Microbiol 5: 555-563. doi: 510.1038/nrmicro1709. 31 11. Sanchez-Trincado JL, Gomez-Perosanz M, Reche PA (2017) Fundamentals and Methods for T- 32 and B-Cell Epitope Prediction. J Immunol Res 2017:2680160.: 10.1155/2017/2680160. Epub 33 2682017 Dec 2680128. 34 12. Moller J, Kraner ME, Burkovski A (2019) Proteomics of Bordetella pertussis whole-cell and 35 acellular vaccines. BMC Res Notes 12: 329. doi: 310.1186/s13104-13019-14373-13102. 36 13. Moller J, Kraner ME, Burkovski A (2019) More than a Toxin: Protein Inventory of Clostridium 37 tetani Toxoid Vaccines. Proteomes 7: 15. doi: 10.3390/proteomes7020015. 38 14. Rodrigues CMC, Chan H, Vipond C, Jolley K, Harrison OB, et al. (2019) Typing complex 39 meningococcal vaccines to understand diversity and population structure of key vaccine 40 antigens. Wellcome Open Res 3:151.: 10.12688/wellcomeopenres.14859.12682. eCollection 41 12018. 42 15. Altschul SF, Madden TL, Sch√§ffer AA, Zhang J, Zhang Z, et al. (1997) Gapped BLAST and 43 PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 44 3389-3402. doi: 3310.1093/nar/3325.3317.3389. 45 16. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, et al. (2007) The human 46 microbiome project. Nature 449: 804-810. doi: 810.1038/nature06244. 47 17. Molero-Abraham M, Lafuente EM, Flower DR, Reche PA (2013) Selection of conserved epitopes 48 from hepatitis C virus for pan-populational stimulation of T-cell responses. Clin Dev 49 Immunol 2013:601943.: 10.1155/2013/601943. Epub 602013 Nov 601921. 50 18. Bui HH, Sidney J, Dinh K, Southwood S, Newman MJ, et al. (2006) Predicting population 51 coverage of T-cell epitope-based diagnostics and vaccines. BMC Bioinformatics 7:153.: 52 10.1186/1471-2105-1187-1153. 53 19. Hubbard SJ, Thornton JM (1993) NACCESS, Computer Program: Department of Biochemistry 54 and Molecular Biology, University College London.

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1 20. Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, et al. (2020) Targets of T Cell Responses 2 to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed 3 Individuals. Cell 20: 30610-30613. 4 21. Ju B, Zhang Q, Ge J, Wang R, Sun J, et al. (2020) Human neutralizing antibodies elicited by 5 SARS-CoV-2 infection. Nature 26: 020-2380. 6 22. Pandhi D, Sonthalia S (2011) Human papilloma virus vaccines: Current scenario. Indian J Sex 7 Transm Dis AIDS 32: 75-85. doi: 10.4103/0253-7184.85409. 8 23. Franklin R, Young A, Neumann B, Fernandez R, Joannides A, et al. (2020) Homologous protein 9 domains in SARS-CoV-2 and measles, mumps and rubella viruses: preliminary evidence that 10 MMR vaccine might provide protection against COVID-19. medRxiv 1: 10. 11 24. Belkaid Y, Hand TW (2014) Role of the microbiota in immunity and inflammation. Cell 157: 12 121-141. doi: 110.1016/j.cell.2014.1003.1011. 13 25. Roughan G, Nishida I (1990) Concentrations of long-chain acyl-acyl carrier proteins during fatty 14 acid synthesis by chloroplasts isolated from pea (Pisum sativum), safflower (Carthamus 15 tinctoris), and amaranthus (Amaranthus lividus) leaves. Arch Biochem Biophys 276: 38-46. 16 doi: 10.1016/0003-9861(1090)90007-l. 17 26. Mosca A, Leclerc M, Hugot JP (2016) Gut Microbiota Diversity and Human Diseases: Should We 18 Reintroduce Key Predators in Our Ecosystem? Front Microbiol 7:455.: 19 10.3389/fmicb.2016.00455. eCollection 02016. 20 27. Miller A, Reandelar MJ, Fasciglione K, Roumenova V, Li Y, et al. (2020) Correlation between 21 universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an 22 epidemiological study. medRxiv 0: 12. 23 28. Curtis N, Sparrow A, Ghebreyesus TA, Netea MG (2020) Considering BCG vaccination to reduce 24 the impact of COVID-19. Lancet 395: 1545-1546. doi: 1510.1016/S0140-6736(1520)31025- 25 31024. Epub 32020 Apr 31030. 26 29. O'Neill LAJ, Netea MG (2020) BCG-induced trained immunity: can it offer protection against 27 COVID-19? Nat Rev Immunol 20: 335-337. doi: 310.1038/s41577-41020-40337-y. 28 30. Mangtani P, Abubakar I, Ariti C, Beynon R, Pimpin L, et al. (2014) Protection by BCG vaccine 29 against tuberculosis: a systematic review of randomized controlled trials. Clin Infect Dis 58: 30 470-480. doi: 410.1093/cid/cit1790. Epub 2013 Dec 1013. 31 31. Arts RJW, Carvalho A, La Rocca C, Palma C, Rodrigues F, et al. (2016) Immunometabolic 32 Pathways in BCG-Induced Trained Immunity. Cell Rep 17: 2562-2571. doi: 33 2510.1016/j.celrep.2016.2511.2011. 34 32. Moorlag S, Arts RJW, van Crevel R, Netea MG (2019) Non-specific effects of BCG vaccine on 35 viral infections. Clin Microbiol Infect 25: 1473-1478. doi: 1410.1016/j.cmi.2019.1404.1020. 36 Epub 2019 May 1472. 37 33. Sanchez-Ramon S, Conejero L, Netea MG, Sancho D, Palomares ì, et al. (2018) Trained 38 Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti- 39 infectious Formulations. Front Immunol 9:2936.: 10.3389/fimmu.2018.02936. eCollection 40 02018. 41 34. Zinkernagel RM (2018) What if protective immunity is antigen-driven and not due to so-called 42 "memory" B and T cells? Immunol Rev 283: 238-246. doi: 210.1111/imr.12648. 43 35. Hamiel U, Kozer E, Youngster I (2020) SARS-CoV-2 Rates in BCG-Vaccinated and 44 Unvaccinated Young Adults. Jama 323: 2340-2341. doi: 2310.1001/jama.2020.8189. 45 36. Ahmad H, Chapnick EK (1999) Conjugated polysaccharide vaccines. Infect Dis Clin North Am 46 13: 113-133, vii. doi: 110.1016/s0891-5520(1005)70046-70045. 47 37. Choe YJ, Blatt DB, Lee HJ, Choi EH (2020) Associations between geographic region and 48 immune response variations to pneumococcal conjugate vaccines in clinical trials: A 49 systematic review and meta-analysis. Int J Infect Dis 92:261-268.: 50 10.1016/j.ijid.2019.1012.1021. 51 38. Cohn AC, MacNeil JR, Clark TA, Ortega-Sanchez IR, Briere EZ, et al. (2013) Prevention and 52 control of meningococcal disease: recommendations of the Advisory Committee on 53 Immunization Practices (ACIP). MMWR Recomm Rep 62: 1-28.

24-26

1 39. Daniels CC, Rogers PD, Shelton CM (2016) A Review of Pneumococcal Vaccines: Current 2 Polysaccharide Vaccine Recommendations and Future Protein Antigens. J Pediatr Pharmacol 3 Ther 21: 27-35. doi: 10.5863/1551-6776-5821.5861.5827. 4 40. Moller J, Kraner M, Sonnewald U, Sangal V, Tittlbach H, et al. (2019) Proteomics of diphtheria 5 toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to 6 protection of humans against Corynebacterium diphtheriae. Vaccine 37: 3061-3070. doi: 7 3010.1016/j.vaccine.2019.3004.3059. Epub 2019 Apr 3026. 8 41. Guiso N, Meade BD, Wirsing von K√∂nig CH (2020) Pertussis vaccines: The first hundred years. 9 Vaccine 38: 1271-1276. doi: 1210.1016/j.vaccine.2019.1211.1022. Epub 2019 Nov 1225. 10 42. Embgenbroich M, Burgdorf S (2018) Current Concepts of Antigen Cross-Presentation. Front 11 Immunol 9:1643.: 10.3389/fimmu.2018.01643. eCollection 02018. 12 43. Lan J, Ge J, Yu J, Shan S, Zhou H, et al. (2020) Structure of the SARS-CoV-2 spike receptor- 13 binding domain bound to the ACE2 receptor. Nature 581: 215-220. doi: 210.1038/s41586- 14 41020-42180-41585. Epub 42020 Mar 41530. 15 44. Shang J, Ye G, Shi K, Wan Y, Luo C, et al. (2020) Structural basis of receptor recognition by 16 SARS-CoV-2. Nature 581: 221-224. doi: 210.1038/s41586-41020-42179-y. Epub 42020 Mar 17 41530. 18 45. Azcarate IG, Marin-Garcia P, Abad P, Peez-Benavente S, Paz-Artal E, et al. (2020) Plasmodium 19 falciparum immunodominant IgG epitopes in subclinical malaria. Sci Rep 10: 9398. doi: 20 9310.1038/s41598-41020-66384-41590. 21 46. Quinzo MJ, Lafuente EM, Zuluaga P, Flower DR, Reche PA (2019) Computational assembly of a 22 human Cytomegalovirus vaccine upon experimental epitope legacy. BMC Bioinformatics 20: 23 476. doi: 410.1186/s12859-12019-13052-12856. 24 47. Alonso-Padilla J, Lafuente EM, Reche PA (2017) Computer-Aided Design of an Epitope-Based 25 Vaccine against Epstein-Barr Virus. J Immunol Res 2017:9363750.: 10.1155/2017/9363750. 26 Epub 9362017 Sep 9363728. 27 48. Kuhdari P, Stefanati A, Lupi S, Valente N, Gabutti G (2016) Meningococcal B vaccination: real- 28 world experience and future perspectives. Pathog Glob Health 110: 148-156. doi: 29 110.1080/20477724.20472016.21195072. Epub 20472016 Jun 20477716. 30 49. Soler-Garcia A, Fernandez de Sevilla M, Abad R, Esteva C, Alsina L, et al. (2019) 31 Meningococcal Serogroup B Disease in Vaccinated Children. J Pediatric Infect Dis Soc 21. 32 50. Goldblatt D (2000) Conjugate vaccines. Clin Exp Immunol 119: 1-3. doi: 10.1046/j.1365- 33 2249.2000.01109.x. 34 51. Sheridan SL, Ware RS, Grimwood K, Lambert SB (2015) Reduced risk of pertussis in whole-cell 35 compared to acellular vaccine recipients is not confounded by age or receipt of booster-doses. 36 Vaccine 33: 5027-5030. doi: 5010.1016/j.vaccine.2015.5008.5021. Epub 2015 Aug 5019. 37 52. van der Lee S, Hendrikx LH, Sanders EAM, Berbers GAM, Buisman AM (2018) Whole-Cell or 38 Acellular Pertussis Primary Immunizations in Infancy Determines Adolescent Cellular 39 Immune Profiles. Front Immunol 9:51.: 10.3389/fimmu.2018.00051. eCollection 02018. 40 41

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2 SUPPLEMENTARY MATERIAL 3

4 Supplementary Table S1. COVID-19 cases and deaths per million in countries implementing DTP

5 with wP or aP antigens.

7 Supplementary Dataset 1. SARS-CoV-2 peptide matches and predicted cross-reactive epitopes in

8 25 human pathogens, including 18 viruses and 7 bacteria.

26-26

Table S1. COVID-19 cases and fatalities per million in different with regard to the use of aP/wP antigens wP aP Countries Cases/ 10^6 Death/ 10^6 Cases 10^6 Death/ 10^6 Albania 365 11 Andorra 9.877 660 Armenia 2.624 33 Austria 1.843 72 Azerbaijan 451 5 Belarus 4.122 23 Belgium 4.971 808 Bosnia and Herzegovina 742 46 Bulgaria 354 19 Croatia 546 25 Cyprus 778 14 Czech Republic 845 30 Denmark 1.983 98 Estonia 1.387 50 Finland 1.208 56 France 2.8 437 Georgia 184 3 Germany 2.167 101 Greece 277 17 Hungary 393 52 Iceland 5.293 29 Ireland 5.015 327 Israel 1.823 31 Italy 3.813 545 Kazakhstan 496 2 Kyrgyzstan 233 2 Latvia 560 12 Lithuania 604 24 Luxembourg 6.393 176 Malta 1.386 16 Monaco 2.499 102 Montenegro 516 14 Netherlands (the) 2.672 343 North Macedonia 979 57 Norway 1.549 43 Poland 589 27 Portugal 3.068 133 Republic of Moldova (the) 1.868 68 Romania 966 64 Russian Federation (the) 2.54 27 San Marino 19.662 1.238 Serbia 1.29 27 Slovakia 278 5 Slovenia 708 52 Spain 6.06 580 Sweden 3.476 418 Switzerland 3.559 222 Tajikistan 360 5 Turkey 1.884 52 Ukraine 501 15 501 15 United Kingdom of Great Britain and Northern Ireland (the) 3.909 546 Uzbekistan 100 0.4

Data collected from hps://www.worldometers.info/coronavirus/ on May 27th 2020. wP/aP vaccinaon obtained from hps://apps.who.int/immunizaon_monitoring/ Supplementary Dataset 1

NUM SARS-CoV-2 ACN SARS-CoV-2 HIT ACN HIT ORGANISM LENGTH ID (%) CoV2 PEP HIT PEP B cell reactivity CD8 T (Predicted HLA I Binding Profile) ** CD4 T (Predicted HLA II Binding Profile)*** SARS_PEPvsHUMAN:ACN[%ID:HU SEQ] SARS_PEPvsMICROBIOME:ACN[%ID:MB SEQ] HIT_PEPvsHUMAN:ACN[%ID:HU SEQ] HIT_PEPvsMICROBIOME:ACN[%ID:MB SEQ] Antigen query sequence [HIT:CoV2]*

1 YP_009724391.1_ORF3a-1-15 MDLFMRIFTIGTVTL WP_003901655.1 BCG 11 81.8 DLFMRIFTIGT DLFMLIFTSGT BNN[-1.6:-1.6] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*11:01, HLA-DRB1*15:01, HLA-DRB4*01:01, HLA-DRB5*01:01] HU:NP_001358898.1[63.6:DNLMRIFTMG] MB:HMPREF0591_2412[81.8:DLFMLIFTSGT] HU:NP_940980.4[54.5:DIFMLIFDA] MB:HMPREF0591_2412[100.0:DLFMLIFTSGT] 2 YP_009724391.1_ORF3a-29-43 VRATATIPIQASLPF WP_003412384.1 BCG 8 87.5 IPIQASLP IPIIASLP BNN[-0.7:0.1] HLAI[NONE] HLAII[NONE] HU:NP_001002811.2[62.5:IPVKSSLP] MB:HMPREF0992_02086[87.5:IPIQATLP] HU:XP_016859930.1[75.0:IPIATSLP] MB:HMPREF9123_0517[87.5:IPIIATLP] 3 YP_009724391.1_ORF3a-89-103 TVYSHLLLVAAGLEA WP_003414124.1 BCG 8 87.5 LVAAGLEA VVAAGLEA BNN[-0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 4 YP_009724391.1_ORF3a-89-103 TVYSHLLLVAAGLEA WP_003418972.1 BCG 8 87.5 LLLVAAGL MLLVAAGL BNN[-1.7:-1.8] HLAI[NONE] HLAII[NONE] HU:XP_011529279.1[87.5:MLLVAAGL] MB:HMPREF9240_00566[100.0:LLLVAAGL] HU:XP_011529279.1[100.0:MLLVAAGL] MB:ALIPUT_01911[87.5:MMLVAAGL] 5 YP_009724391.1_ORF3a-245-259 QIHTIDGSSGVVNPV YP_009173870.1 HBV 8 87.5 SSGVVNPV SSGTVNPV BYY[1.1:0.5] HLAI[NONE] HLAII[NONE] HU:NP_004406.2[75.0:SGGVVDPV] MB:HMPREF0220_0555[75.0:SSGMINPV] HU:NP_001171563.1[87.5:SSGTFNPV] MB:HMPREF9007_04847[87.5:SQGTVNPV] 6 YP_009725306_NSP10-13-27 VLSFCAFAVDAAKAY WP_003406629.1 BCG 9 88.9 FAVDAAKAY FAVDAASAY BNY[0.2:1.0] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[HLA-DRB1*03:01, HLA-DRB3*01:01] HU:NO[NO] MB:GCWU000321_01831[77.8:YAVDAAKSY] HU:XP_011524280.1[77.8:AVDAATAY] MB:HMPREF0179_05163[88.9:FADDAASAY] 7 YP_009725306_NSP10-45-59 LCTHTGTGQAITVTP WP_011799102.1 BCG 9 88.9 TGTGQAITV TGTGPAITV BYY[1.1:0.7] HLAI[NONE] HLAII[NONE] HU:NP_001265486.1[66.7:TGTGEAVAV] MB:COPEUT_00962[77.8:TGSGQMITV] HU:NO[NO] MB:HMPREF1532_02796[77.8:TGTGPLIEV] 8 YP_009725306_NSP10-41-55 CVKMLCTHTGTGQAI WP_003400126.1 BCG 8 87.5 THTGTGQA THPGTGQA BYY[1.9:1.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9007_04663[87.5:THTGTGSA] HU:NO[NO] MB:HMPREF9701_00125[75.0:SHPGNGQA] 9 YP_009725307_POL-125-139 ADLVYALRHFDEGNC WP_003406912.1 BCG 10 80.0 VYALRHFDEG VYALRNMDEG BNN[-0.2:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_644813.1[70.0:VYATRHFQAG] MB:HMPREF1343_00546[70.0:IYALQHFDE] HU:NP_056041.1[60.0:VYSLENQDKG] MB:HMPREF1211_08309[80.0:VYGLRNLDEG] 10 YP_009725307_POL-577-591 KSIAATRGATVVIGT WP_003405726.1 BCG 10 80.0 TRGATVVIGT TRGAVVVVGT BNN[-0.4:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_006550.1[70.0:TRGATVTRG] MB:HMPREF9441_00457[80.0:TKGETVVIGT] HU:XP_011531211.1[70.0:SRGAVVGVG] MB:HMPREF1168_02454[80.0:RGAQVVVGT] 11 YP_009725307_POL-833-847 DPSRILGAGCFVDDI WP_003416097.1 BCG 10 80.0 ILGAGCFVDD IMFAGCFVDD BNN[-1.1:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_665814.1[60.0:LLGAGCFL] MB:HMPREF9622_01468[70.0:LLGSGCFVD] HU:XP_006717045.1[60.0:IVFAACFLPD] MB:HMPREF9488_00884[60.0:MYAGCFID] 12 YP_009725307_POL-169-183 PDILRVYANLGERVR WP_003419627.1 BCG 8 87.5 ANLGERVR AELGERVR BYN[0.5:0.2] HLAI[NONE] HLAII[NONE] HU:NP_002244.1[75.0:ATVGERVR] MB:HMPREF9095_1006[87.5:ANVGERVR] HU:NP_002244.1[75.0:ATVGERVR] MB:NO[NO] 13 YP_009725307_POL-241-255 LMPILTLTRALTAES WP_003414592.1 BCG 8 87.5 LTLTRALT LTLVRALT BNN[-1.4:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1007_03402[87.5:LTLTRSLT] HU:NO[NO] MB:HMPREF1045_1936[87.5:MTLVRALT] 14 YP_009725307_POL-673-687 LYVKPGGTSSGDATT WP_003900845.1 BCG 8 87.5 PGGTSSGD PGGMSSGD BYY[1.6:2.3] HLAI[NONE] HLAII[NONE] HU:NP_001317368.1[75.0:PGGTPAGD] MB:HMPREF0428_00125[87.5:PGGFSSGD] HU:XP_005264389.2[62.5:PGGETAGD] MB:HMPREF1250_1949[87.5:PGGMGSGD] 15 YP_009725307_POL-765-779 CFNSTYASQGLVASI WP_011799240.1 BCG 8 87.5 SQGLVASI SGGLVASI BNN[-0.3:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:XP_016877510.1[75.0:AGGLVAAI] MB:NO[NO] 16 YP_009725301_3CPR-69-83 QAGNVQLRVIGHSMQ WP_003900454.1 BCG 8 87.5 GNVQLRVI GNVQLRGI BNN[-0.4:-0.9] HLAI[NONE] HLAII[NONE] HU:NP_079029.3[62.5:GHVQLRIM] MB:HMPREF1056_01785[75.0:GNVQFRVV] HU:NP_065095.2[75.0:GNVKLKGI] MB:HMPREF0018_00901[87.5:GNVQLRGL] 17 YP_009725301_3CPR-109-123 GQTFSVLACYNGSPS WP_003411946.1 BCG 8 87.5 TFSVLACY TFSVLAAY BNN[-1.1:-1.5] HLAI[NONE] HLAII[NONE] HU:XP_011510669.1[87.5:TFSVLAYY] MB:CIY_02610[75.0:TFKVIACY] HU:NP_001269488.1[87.5:TFSVLAYY] MB:HMPREF9246_1655[87.5:TFSVLASY] 18 YP_009725301_3CPR-185-199 FVDRQTAQAAGTDTT WP_003407487.1 BCG 8 87.5 AQAAGTDT AQATGTDT BYY[1.6:1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF9151_01554[87.5:AQSTGTDT] 19 YP_009725301_3CPR-273-287 QNGMNGRTILGSALL WP_003414635.1 BCG 8 87.5 TILGSALL TLLGSALL BNN[-1.1:-1.0] HLAI[NONE] HLAII[NONE] HU:NP_008879.3[87.5:TILGSAVL] MB:NO[NO] HU:NP_001248357.1[75.0:TLVGGALL] MB:NO[NO] 20 YP_009725311_2ORMT-245-259 FDMSKFPLKLRGTAV WP_003898626.1 BCG 8 87.5 PLKLRGTA PLKLAGTA BNN[-0.0:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9456_01611[87.5:PLKIRGTA] HU:NP_001287817.1[75.0:PLKLLGTG] MB:COPCOM_01139[87.5:PLKLTGTA] 21 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_003400005.1 BCG 10 80.0 LQGPPGTGKS LVGPPGTGKT BYY[1.9:2.2] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:XP_016865699.1[90.0:MVGPPGTGKT] MB:BACCOP_00685[100.0:LVGPPGTGKT] 22 YP_009725308_HEL-281-295 QGPPGTGKSHFAIGL WP_003403363.1 BCG 10 80.0 GPPGTGKSHF GPSGTGKSVF BYY[1.4:1.9] HLAI[NONE] HLAII[NONE] HU:XP_011540546.1[80.0:GPPGTGKTLF] MB:HMPREF9402_1702[90.0:GPPGTGKSH] HU:NP_061720.2[80.0:GPTGTGKSVY] MB:HMPREF9104_02512[90.0:GPSGTGKSTF] 23 YP_009725308_HEL-357-371 FCTVNALPETTADIV WP_003900761.1 BCG 10 80.0 VNALPETTAD VNALRELTAD BNY[-0.3:1.0] HLAI[NONE] HLAII[NONE] HU:NP_055426.1[80.0:VNALPETLSD] MB:EDWATA_00953[70.0:VNSLPQTEAD] HU:XP_016858793.1[60.0:VNAVRQLT] MB:HMPREF1534_00041[90.0:VNALRELGAD] 24 YP_009725308_HEL-481-495 THDVSSAINRPQIGV WP_003419703.1 BCG 10 80.0 VSSAINRPQI LSAAINRPQI BNY[0.1:0.4] HLAI[NONE] HLAII[NONE] HU:NP_001291299.1[50.0:SSVNRPRI] MB:COPCOM_03227[70.0:SSAINRPEL] HU:NP_000585.2[70.0:LSAEINRP] MB:HMPREF0591_2586[100.0:LSAAINRPQI] 25 YP_009725308_HEL-485-499 SSAINRPQIGVVREF WP_003419703.1 BCG 9 88.9 SSAINRPQI SAAINRPQI BYY[1.0:0.6] HLAI[NONE] HLAII[NONE] HU:NP_001291299.1[55.6:SSVNRPRI] MB:COPCOM_03227[77.8:SSAINRPEL] HU:XP_005246697.1[55.6:AAAVRRPQV] MB:HMPREF0591_2586[100.0:SAAINRPQI] 26 YP_009725308_HEL-9-23 NSQTSLRCGACIRRP WP_003414814.1 BCG 8 87.5 RCGACIRR RCGAVIRR BNN[-0.7:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_024303299.1[75.0:RCGHCVRR] MB:HMPREF0322_01453[87.5:RCPACIRR] HU:NP_004318.3[75.0:RCKASIRR] MB:HMPREF0178_01847[75.0:QCGAVVRR] 27 YP_009725308_HEL-33-47 HVISTSHKLVLSVNP WP_010950418.1 BCG 8 87.5 KLVLSVNP KLVLDVNP BNN[-0.7:-0.9] HLAI[NONE] HLAII[NONE] HU:NP_957718.1[62.5:KIVLNFNP] MB:BACCOP_03689[87.5:QLVLSVNP] HU:XP_016856643.1[75.0:KLILDVQP] MB:HMPREF0358_1908[87.5:KLILDVNP] 28 YP_009725308_HEL-45-59 VNPYVCNAPGCDVTD WP_003405897.1 BCG 8 87.5 CNAPGCDV CSAPGCDV BYY[0.9:0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0591_0914[75.0:CSHPGCDV] HU:NP_005760.1[75.0:CSAPACDI] MB:HMPREF0591_1213[87.5:CSHPGCDV] 29 YP_009725308_HEL-89-103 VFGLYKNTCVGSDNV WP_003417249.1 BCG 8 87.5 FGLYKNTC FGLTKNTC BNN[-0.0:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_004121.2[75.0:FGLVKDTC] MB:HMPREF0023_0234[87.5:FRLYKNTC] HU:NP_004121.2[75.0:FGLVKDTC] MB:HMPREF1006_00519[75.0:FNLTRNTC] 30 YP_009725308_HEL-205-219 YGDAVVYRGTTTYKL WP_072516028.1 BCG 8 87.5 GDAVVYRG GDAVVGRG BYN[0.5:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0490_00981[75.0:GDQVIYRG] HU:NO[NO] MB:HMPREF0591_3760[100.0:GDAVVGRG] 31 YP_009725308_HEL-273-287 GMQKYSTLQGPPGTG WP_003419543.1 BCG 8 87.5 LQGPPGTG LYGPPGTG BYY[2.0:2.3] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF1068_02855[100.0:LQGPPGTG] HU:NP_000457.1[100.0:LYGPPGTG] MB:HMPREF1323_1465[100.0:LYGPPGTG] 32 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_003401463.1 BCG 8 87.5 GPPGTGKS GPPGTGKT BYY[2.6:2.6] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] HU:NP_066363.1[100.0:GPPGTGKT] MB:COLSTE_00461[100.0:GPPGTGKT] 33 YP_009725308_HEL-305-319 VYTACSHAAVDALCE WP_011799124.1 BCG 8 87.5 AAVDALCE GAVDALCE BNN[-0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:BACSTE_01645[87.5:AAVDSLCE] HU:XP_016863804.1[62.5:GAIDAFCQ] MB:HMPREF9710_02509[87.5:GALDALCE] 34 YP_009725308_HEL-313-327 AVDALCEKALKYLPI WP_011799124.1 BCG 8 87.5 AVDALCEK AVDALCEQ BNN[-0.4:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:BACCAC_00457[87.5:AVDAFCEK] HU:NP_113679.1[75.0:ARDAVCEQ] MB:HMPREF1032_03807[87.5:AADALCEQ] 35 YP_009725308_HEL-421-435 YFNSVCRLMKTIGPD WP_003899489.1 BCG 8 87.5 LMKTIGPD LMKTFGPD BNN[0.2:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9331_02204[87.5:LHKTIGPD] HU:NP_078813.1[62.5:FLKTFSPD] MB:HMPREF1076_01816[87.5:LMKTFDPD] 36 YP_009725297_LP-81-95 HGHVMVELVAELEGI WP_003416879.1 BCG 8 87.5 ELVAELEG ELIAELEG BNN[-0.5:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_660215.1[87.5:ELIAELEG] MB:HMPREF1014_01110[87.5:ELIAELEG] HU:NP_660215.1[100.0:ELIAELEG] MB:HMPREF0591_4115[100.0:ELIAELEG] 37 YP_009725297_LP-125-139 KNGNKGAGGHSYGAD WP_003402145.1 BCG 8 87.5 AGGHSYGA AGGHSYGG BYY[1.2:1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0291_11857[87.5:AGGHSYGS] HU:XP_011516871.1[75.0:GGSHSYGG] MB:HMPREF0758_3704[87.5:AGGHSYAG] 38 YP_009724395.1_ORF7a-73-87 HVYQLRARSVSPKLF WP_003408382.1 BCG 10 80.0 HVYQLRARSV HDPQLRARSV BYN[0.4:-0.6] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_001296122.1[60.0:YVFQVRARTV] MB:HMPREF9439_00887[80.0:HVYPLRARS] HU:NP_689829.3[60.0:DPQLRLHSI] MB:HMPREF0290_0252[80.0:DPQLRARCV] 39 YP_009725298_NSP2-25-39 LARAGKASCTLSEQL WP_003419207.1 BCG 10 80.0 RAGKASCTLS RAGKCSGTLS BYN[0.6:0.3] HLAI[HLA-B*07:02] HLAII[NONE] HU:XP_016868659.1[80.0:RSGKASCTL] MB:HMPREF1032_01276[80.0:RAGKAFCTL] HU:NP_001035263.1[80.0:RAGPFSGTLS] MB:CBFG_00901[70.0:AGNCSGTL] 40 YP_009725298_NSP2-93-107 FVFPLNSIIKTIQPR WP_011799364.1 BCG 10 80.0 NSIIKTIQPR SSIIKTIQDR BNN[-0.2:-0.1] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[NONE] HU:XP_011542783.1[60.0:NNIISTVQP] MB:HMPREF9720_2482[80.0:NSLIKTLQPR] HU:NP_055714.3[70.0:SSIIRTTQD] MB:HMPREF0591_2568[100.0:SSIIKTIQDR] 41 YP_009725298_NSP2-353-367 LYAFASEAARVVRSI WP_010950909.1 BCG 10 80.0 AFASEAARVV AFAAEGARVV BNN[0.2:0.0] HLAI[HLA-A*24:02, HLA-B*35:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*07:01, HLA-DRB1*09:01, HLA-DRB3*01:01] HU:XP_011525174.1[60.0:AYAAEAARL] MB:HMPREF9138_00550[80.0:AFAKEAARVI] HU:XP_005263197.1[70.0:AFAREGAKVI] MB:HMPREF0591_2451[100.0:AFAAEGARVV] 42 YP_009725298_NSP2-565-579 ETLPTEVLTEEVVLK WP_003900169.1 BCG 10 80.0 PTEVLTEEVV PVEVLTETVV BNY[-0.3:0.6] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:XP_016873953.1[70.0:PDEVLTKEV] MB:CUU_2963[70.0:PTEVVTEQV] HU:XP_016869458.1[60.0:PVEIHTATVI] MB:RHOER0001_5708[70.0:PVEITTETV] 43 YP_009725298_NSP2-589-603 PTSEAVEAPLVGTPV WP_003900454.1 BCG 10 80.0 AVEAPLVGTP AIEAPLVITP BNY[-0.3:0.5] HLAI[HLA-B*40:01, HLA-B*44:03] HLAII[NONE] HU:NO[NO] MB:HMPREF9728_01785[70.0:EMPLVGTP] HU:XP_016872345.1[60.0:IEDPLIVTP] MB:HMPREF0591_1146[100.0:AIEAPLVITP] 44 YP_009725298_NSP2-585-599 PLEQPTSEAVEAPLV WP_003410645.1 BCG 9 88.9 QPTSEAVEA RPTSEAVEA BYY[1.2:1.3] HLAI[HLA-B*35:01] HLAII[NONE] HU:NP_849188.4[77.8:QPESEGVEA] MB:HMPREF9454_01988[77.8:QPTKEAVE] HU:NP_004659.2[66.7:RPTYEAVQ] MB:HMPREF0591_1138[88.9:RPTSEAVEG] 45 YP_009725298_NSP2-17-31 PLECIKDLLARAGKA WP_003414061.1 BCG 8 87.5 DLLARAGK DLLARAAK BNN[-0.5:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0177_02019[87.5:DLIARAGK] HU:NP_065983.1[75.0:DLLNRAAR] MB:HMPREF9141_0087[87.5:DLIARAAK] 46 YP_009725298_NSP2-237-251 HNKCAYWVPRASANI WP_003910517.1 BCG 8 87.5 VPRASANI VPRASAVI BNY[0.2:0.6] HLAI[HLA-B*07:02, HLA-B*08:01] HLAII[NONE] HU:XP_006716254.1[62.5:IPRSRANI] MB:HMPREF0992_01928[75.0:VPKAAANI] HU:NP_001271145.1[62.5:LPRSSAVV] MB:NEIFL0001_0427[87.5:VPRASAVV] 47 YP_009725298_NSP2-261-275 EGSEGLNDNLLEILQ WP_003401613.1 BCG 8 87.5 EGSEGLND EGSEGLRD BYY[1.2:1.3] HLAI[NONE] HLAII[NONE] HU:NP_055640.2[75.0:EGSEGLDE] MB:ENTCAN_05037[87.5:EGEEGLND] HU:NO[NO] MB:HMPREF0591_3372[100.0:EGSEGLRD] 48 YP_009725298_NSP2-277-291 EKVNINIVGDFKLNE WP_003401091.1 BCG 8 87.5 IVGDFKLN IVGDFKTN BNN[0.1:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9257_0594[75.0:LIGDFKLN] HU:NO[NO] MB:HMPREF0591_3230[100.0:IVGDFKTN] 49 YP_009725298_NSP2-541-555 VKSREETGLLMPLKA WP_010950388.1 BCG 8 87.5 ETGLLMPL ETGLLFPL BNN[-1.1:-1.0] HLAI[NONE] HLAII[NONE] HU:NP_057594.5[62.5:ETGIVMPV] MB:RUMHYD_02234[87.5:ETGILMPL] HU:NO[NO] MB:HMPREF1450_01498[75.0:ETGLIFPI] 50 YP_009725298_NSP2-581-595 GDLQPLEQPTSEAVE WP_003410645.1 BCG 8 87.5 QPTSEAVE RPTSEAVE BYY[1.4:1.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9454_01988[87.5:QPTKEAVE] HU:NP_004659.2[75.0:RPTYEAVQ] MB:HMPREF0591_1138[100.0:RPTSEAVE] 51 YP_009725298_NSP2-589-603 PTSEAVEAPLVGTPV WP_003410645.1 BCG 8 100.0 PTSEAVEA PTSEAVEA BYY[1.2:1.2] HLAI[NONE] HLAII[NONE] HU:XP_011541346.1[75.0:PTSEEIEA] MB:NO[NO] HU:XP_011541346.1[75.0:PTSEEIEA] MB:NO[NO] 52 YP_009724393.1_MP-5-19 NGTITVEELKKLLEQ WP_003409919.1 BCG 9 88.9 EELKKLLEQ EELKKLLYQ BNN[-0.9:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_757366.2[77.8:EELKKLIEE] MB:CLOSTHATH_05611[77.8:EEMKQLLEQ] HU:NP_000255.2[77.8:EELKKINYQ] MB:SUBVAR_05006[88.9:EELKKLLYK] 53 YP_009724393.1_MP-101-115 RLFARTRSMWSFNPE WP_003898763.1 BCG 8 87.5 TRSMWSFN TRSAWSFN BNN[0.1:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0580_2314[62.5:TRTLWSYN] HU:NO[NO] MB:CLOSPO_03764[75.0:TKSKWSFN] 54 YP_009724393.1_MP-133-147 LLESELVIGAVILRG WP_003405938.1 BCG 8 87.5 LVIGAVIL LVIGAVML BNN[-1.7:-1.8] HLAI[NONE] HLAII[NONE] HU:NP_115828.2[75.0:LVVGAVAL] MB:NO[NO] HU:NP_115828.2[75.0:LVVGAVAL] MB:RUMOBE_01323[75.0:LIVGAVML] 55 YP_009725299_NSP3-321-335 NQHEVLLAPLLSAGI WP_003408381.1 BCG 11 81.8 HEVLLAPLLSA HEVLLAALESA BNN[-1.0:-1.2] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01] HU:XP_005247960.1[63.6:HDVTLSPVLSA] MB:BACUNI_00358[63.6:HELLLSPLL] HU:XP_011535063.1[72.7:EVLLPALEAA] MB:HMPREF0591_0601[90.9:HDVLLAALESA] 56 YP_009725299_NSP3-325-339 VLLAPLLSAGIFGAD WP_003409345.1 BCG 11 81.8 LAPLLSAGIFG LAPLLCAGIIG BNN[-1.2:-0.7] HLAI[HLA-B*07:02] HLAII[NONE] HU:NP_001119580.2[72.7:FAPLITAGIFG] MB:HMPREF9166_1794[72.7:PLLSAGVFG] HU:NP_001350451.1[63.6:PLLIAGVIG] MB:HMPREF9104_01057[90.9:APLLCAGIIG] 57 YP_009725299_NSP3-589-603 KGIKIQEGVVDYGAR WP_003406648.1 BCG 10 80.0 QEGVVDYGAR QEGVVDEGGR BYY[1.2:0.6] HLAI[NONE] HLAII[NONE] HU:XP_016855783.1[70.0:QEGVVDCGG] MB:HMPREF1207_01853[70.0:QEGVVEYG] HU:XP_016855783.1[80.0:QEGVVDCGG] MB:HMPREF0591_5269[100.0:QEGVVDEGGR] 58 YP_009725299_NSP3-613-627 VASLINTLNDLNETL WP_137054067.1 BCG 10 80.0 NTLNDLNETL STLLDLNETL BNN[-0.6:0.1] HLAI[HLA-A*02:01] HLAII[NONE] HU:NO[NO] MB:EDWATA_00060[80.0:TLNDLNELL] HU:NP_001278744.1[70.0:LLDLNHTL] MB:CK5_23860[80.0:SNLLDLNETI] 59 YP_009725299_NSP3-321-335 NQHEVLLAPLLSAGI WP_003409345.1 BCG 9 88.9 LAPLLSAGI LAPLLCAGI BNN[-1.3:-0.7] HLAI[NONE] HLAII[NONE] HU:XP_024307072.1[77.8:LAPLLSHG] MB:HMPREF0044_0816[100.0:LAPLLSAGI] HU:NP_001827.1[66.7:GPLLCAGV] MB:HMPREF9456_01997[88.9:IAPLLCAGI] 60 YP_009725299_NSP3-1789-1803 EKLKTLVATAEAELA WP_011799075.1 BCG 9 88.9 VATAEAELA VATALAELA BNY[-0.6:1.2] HLAI[NONE] HLAII[NONE] HU:NP_065706.2[66.7:LGEAEAELA] MB:HMPREF0351_11418[77.8:IETAEAELA] HU:NP_116030.1[77.8:VATALAPL] MB:NO[NO] 61 YP_009725299_NSP3-1797-1811 TAEAELAKNVSLDNV WP_003399810.1 BCG 9 88.9 ELAKNVSLD ELAKLVSLD BNN[-1.0:-0.1] HLAI[NONE] HLAII[HLA-DRB1*04:01, HLA-DRB1*08:02] HU:XP_011536322.1[66.7:ELARNVAL] MB:HMPREF0078_0342[77.8:ELAKNIKLD] HU:XP_016855909.1[77.8:ELAQLISLD] MB:HMPREF0198_1566[100.0:ELAKLVSLD] 62 YP_009725299_NSP3-229-243 EEAKKVKPTVVVNAA WP_003899883.1 BCG 8 87.5 PTVVVNAA PTSVVNAA BYN[0.4:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_016858448.1[75.0:PPVVINAA] MB:NO[NO] HU:XP_005261753.1[75.0:PTSLVNMA] MB:ROSEINA2194_02695[75.0:PTSVINAS] 63 YP_009725299_NSP3-317-331 YENFNQHEVLLAPLL WP_003408381.1 BCG 8 87.5 HEVLLAPL HEVLLAAL BNN[-1.7:-1.3] HLAI[HLA-B*40:01, HLA-B*44:03] HLAII[NONE] HU:NO[NO] MB:BACPEC_00895[87.5:HEVLLVPL] HU:NP_056091.1[75.0:HEFLIAAL] MB:NO[NO] 64 YP_009725299_NSP3-321-335 NQHEVLLAPLLSAGI WP_003900344.1 BCG 8 100.0 LAPLLSAG LAPLLSAG BNN[-0.5:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_024307072.1[87.5:LAPLLSHG] MB:HMPREF1486_02279[100.0:LAPLLSAG] HU:XP_024307072.1[87.5:LAPLLSHG] MB:HMPREF1486_02279[100.0:LAPLLSAG] 65 YP_009725299_NSP3-321-335 NQHEVLLAPLLSAGI WP_003415965.1 BCG 8 87.5 APLLSAGI APLLCAGI BNN[-1.2:-0.4] HLAI[NONE] HLAII[NONE] HU:XP_006717059.1[87.5:APLTSAGI] MB:HMPREF9404_5904[87.5:APLLSAGV] HU:NP_001827.1[75.0:GPLLCAGV] MB:HMPREF1451_00373[100.0:APLLCAGI] 66 YP_009725299_NSP3-321-335 NQHEVLLAPLLSAGI WP_003406613.1 BCG 8 87.5 VLLAPLLS VLLAGLLS BNN[-1.8:-1.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_002293.2[75.0:LLLAGLIS] MB:HOLDEFILI_00753[100.0:VLLAGLLS] 67 YP_009725299_NSP3-325-339 VLLAPLLSAGIFGAD WP_003405938.1 BCG 8 87.5 LLSAGIFG LLLAGIFG BNN[-1.8:-0.9] HLAI[NONE] HLAII[NONE] HU:XP_011513022.1[87.5:LYSAGIFG] MB:CLOHIR_01837[100.0:LLSAGIFG] HU:NP_038465.1[62.5:LFLAGVYG] MB:HMPREF0908_1820[87.5:LLLAGVFG] 68 YP_009725299_NSP3-341-355 IHSLRVCVDTVRTNV WP_003406057.1 BCG 8 87.5 VDTVRTNV VDTVRTIV BNY[-0.4:0.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9081_0465[62.5:IDTLRTNI] HU:NO[NO] MB:HMPREF9138_00918[87.5:VDTVRTVV] 69 YP_009725299_NSP3-353-367 TNVYLAVFDKNLYDK WP_010950849.1 BCG 8 87.5 LAVFDKNL LAVFDANL BNN[-0.9:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:PROPEN_00828[87.5:LAVFDKDL] HU:NP_942568.2[75.0:LAVLDANM] MB:HMPREF0591_4124[87.5:LAAFDANL] 70 YP_009725299_NSP3-649-663 RSLKVPATVSVSSPD WP_003412657.1 BCG 8 87.5 ATVSVSSP APVSVSSP BYY[0.9:0.6] HLAI[NONE] HLAII[NONE] HU:NP_663780.2[87.5:ATVEVSSP] MB:CORTU0001_0803[87.5:ATVSVSAP] HU:NO[NO] MB:HMPREF9623_00715[87.5:APVSVSRP] 71 YP_009725299_NSP3-721-735 SNPTTFHLDGEVITF WP_003899337.1 BCG 8 87.5 LDGEVITF LPGEVITF BNN[-0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_079170.2[75.0:LDSEVVTF] MB:HMPREF1211_03948[87.5:LDGEVISF] HU:NO[NO] MB:HMPREF1061_00218[87.5:LPGESITF] 72 YP_009725299_NSP3-1097-1111 VPNQPYPNASFDNFK WP_071854212.1 BCG 8 87.5 PYPNASFD PYPDASFD BYY[1.5:1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:EUBHAL_00385[87.5:PYPNDSFD] HU:NO[NO] MB:HMPREF9555_02233[87.5:PFPDASFD] 73 YP_009725299_NSP3-1125-1139 QLTGYKKPASRELKV WP_003408148.1 BCG 8 87.5 QLTGYKKP ELTGYKKP BYY[0.7:0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9701_01653[87.5:QLTGYKRP] HU:XP_011508367.1[62.5:ELSGHRKP] MB:HMPREF9997_00291[87.5:ELTGFKKP] 74 YP_009725299_NSP3-1373-1387 KASMPTTIAKNTVKS WP_003414864.1 BCG 8 87.5 IAKNTVKS ISKNTVKS BYY[0.5:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0010_00137[87.5:IARNTVKS] HU:NP_000330.3[75.0:ITKNRVKS] MB:HMPREF9404_4822[87.5:LSKNTVKS] 75 YP_009725299_NSP3-1517-1531 TRFFYVLGLAAIMQL WP_003899293.1 BCG 8 87.5 GLAAIMQL GLAAQMQL BNN[-0.5:-1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 76 YP_009725299_NSP3-1601-1615 TRVECTTIVNGVRRS WP_003403503.1 BCG 8 87.5 IVNGVRRS IVNGVRTS BNY[0.0:0.8] HLAI[NONE] HLAII[NONE] HU:XP_005246722.1[75.0:IVNGTKRS] MB:HMPREF1074_03207[75.0:IVDGIRRS] HU:NO[NO] MB:HMPREF9489_1768[87.5:IVNGVKTS] 77 YP_009725299_NSP3-1729-1743 SKCEESSAKSASVYY WP_003415003.1 BCG 8 87.5 SSAKSASV SSAPSASV BYY[1.5:1.0] HLAI[NONE] HLAII[NONE] HU:NP_001307966.1[87.5:SSAPSASV] MB:NO[NO] HU:NP_001339589.1[87.5:TSAPSASV] MB:NO[NO] 78 YP_009725299_NSP3-1813-1827 STFISAARQGFVDSD WP_011799124.1 BCG 8 87.5 TFISAARQ TTISAARQ BYN[1.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_036347.1[75.0:TLISAARE] MB:PROVRETT_06647[75.0:TFVEAARQ] HU:NP_036347.1[75.0:TLISAARE] MB:NO[NO] 79 YP_009725304_NSP8-33-47 VVLKKLKKSLNVAKS WP_003403446.1 BCG 8 87.5 KSLNVAKS KSLNVAGS BNN[0.1:-0.0] HLAI[NONE] HLAII[NONE] HU:XP_006720790.1[75.0:KSLNVSSS] MB:NO[NO] HU:XP_016862473.1[75.0:QTLNVAGS] MB:CBFG_02767[75.0:KSLNIAGT] 80 YP_009724392.1_ENV-21-35 LAFVVFLLVTLAILT WP_003418342.1 BCG 10 80.0 VVFLLVTLAI VVFLGVNLAI BNN[-1.7:-2.6] HLAI[HLA-A*23:01, HLA-A*24:02] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*13:02, HLA-DRB1*15:01] HU:XP_011542979.1[70.0:VFLLVTLQV] MB:HMPREF9395_2234[80.0:IVFLLATLAI] HU:XP_011530477.1[60.0:IFLGINLA] MB:HMPREF9240_00458[80.0:VFMGVNLAI] 81 YP_009724392.1_ENV-25-39 VFLLVTLAILTALRL WP_003898430.1 BCG 10 80.0 LVTLAILTAL LVGLAILTAI BNN[-1.7:-1.9] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*08:02] HU:XP_006723099.1[70.0:VTLQVLTAL] MB:HMPREF0013_01817[80.0:LITLAMLTAL] HU:XP_011533048.1[80.0:LVGLALLTLI] MB:HMPREF0072_2015[90.0:LVGLAILNAI] 82 YP_009724392.1_ENV-13-27 IVNSVLLFLAFVVFL WP_003402870.1 BCG 9 88.9 LLFLAFVVF LLVLAFVVF BNN[-2.9:-3.1] HLAI[NONE] HLAII[HLA-DRB1*01:01] HU:XP_024308117.1[66.7:LLFLVFVI] MB:HMPREF1075_03135[88.9:LLFIAFVVF] HU:NP_001273319.1[88.9:LLVSAFVVF] MB:STRINF_01202[77.8:LIVLAFVIF] 83 YP_009724392.1_ENV-1-15 MYSFVSEETGTLIVN WP_003403012.1 BCG 8 87.5 ETGTLIVN ETGTLIWN BNN[-0.3:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1076_02963[87.5:ETGTLLVN] HU:NO[NO] MB:HMPREF0995_01839[75.0:EAGTVIWN] 84 YP_009724392.1_ENV-17-31 VLLFLAFVVFLLVTL WP_003419809.1 BCG 8 87.5 VVFLLVTL VVFTLVTL BNN[-2.0:-2.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1481_01651[87.5:VIFLLVTL] HU:XP_016860656.1[87.5:VYFTLVTL] MB:NO[NO] 85 YP_009724390.1_SPIKE-593-607 GGVSVITPGTNTSNQ WP_011799143.1 BCG 10 80.0 VSVITPGTNT VSVIDPATNT BYY[0.7:0.8] HLAI[NONE] HLAII[NONE] HU:NP_001305754.1[70.0:VSVVTPGCN] MB:HMPREF0576_0489[70.0:SIITPGTN] HU:NP_001244123.1[70.0:VEVYDPGTNT] MB:EIKCOROL_01227[80.0:AVIDPATNT] 86 YP_009724390.1_SPIKE-717-731 NFTISVTTEILPVSM WP_003401149.1 BCG 10 80.0 ISVTTEILPV IYVTAEILPV BNN[-0.8:-0.4] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*07:01] HU:NP_619648.1[70.0:ISVTEEMLPI] MB:HMPREF9013_0361[80.0:IPVTTEILPI] HU:XP_005255258.1[70.0:IYVTMEIL] MB:HMPREF0591_3253[100.0:IYVTAEILPV] 87 YP_009724390.1_SPIKE-761-775 TQLNRALTGIAVEQD WP_011799079.1 BCG 10 80.0 LNRALTGIAV LGRALTGIRV BNN[-0.6:-0.6] HLAI[NONE] HLAII[HLA-DRB1*01:01] HU:XP_011530891.1[70.0:FNRNLTGYAV] MB:HMPREF0666_02243[80.0:LNRTLTGIA] HU:XP_016866098.1[60.0:LGRAMTGL] MB:HOLDEFILI_00551[80.0:LGRALDGIR] 88 YP_009724390.1_SPIKE-21-35 RTQLPPAYTNSFTRG WP_003418342.1 BCG 8 87.5 AYTNSFTR AWTNSFTR BYY[1.1:1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0591_1074[87.5:AWTNSFTR] HU:NO[NO] MB:HMPREF0591_1074[100.0:AWTNSFTR] 89 YP_009724390.1_SPIKE-281-295 ENGTITDAVDCALDP WP_003900339.1 BCG 8 87.5 ENGTITDA EDGTITDA BYY[1.1:1.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9448_01928[87.5:ENGVITDA] HU:NO[NO] MB:CL2_19980[87.5:EEGTITDA] 90 YP_009724390.1_SPIKE-285-299 ITDAVDCALDPLSET WP_011799317.1 BCG 8 87.5 DAVDCALD DAQDCALD BYN[1.1:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_011529210.1[62.5:DSLDCSLD] MB:HMPREF9156_00232[87.5:DLVDCALD] HU:XP_011518011.1[62.5:DSQDCSRD] MB:HMPREF9240_00750[87.5:DAPDCALD] 91 YP_009724390.1_SPIKE-397-411 ADSFVIRGDEVRQIA WP_003898930.1 BCG 8 87.5 GDEVRQIA GDEVRDIA BYY[0.6:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1705_00035[87.5:GDEVKQIA] HU:NO[NO] MB:HMPREF0591_0458[100.0:GDEVRDIA] 92 YP_009724390.1_SPIKE-397-411 ADSFVIRGDEVRQIA WP_003419367.1 BCG 8 87.5 VIRGDEVR VRRGDEVR BYY[0.8:0.4] HLAI[NONE] HLAII[NONE] HU:XP_016869812.1[75.0:VIRGDTLR] MB:HMPREF9320_1346[87.5:VIRGDEYR] HU:NP_001123543.1[62.5:IRRGDDLR] MB:HMPREF1144_5090[87.5:VRKGDEVR] 93 YP_009724390.1_SPIKE-565-579 FGRDIADTTDAVRDP WP_003415991.1 BCG 8 87.5 ADTTDAVR ADTIDAVR BNY[0.3:1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9320_1782[87.5:ADTTDCVR] HU:XP_011511585.1[62.5:ADSVDAVQ] MB:HMPREF0591_6024[100.0:ADTIDAVR] 94 YP_009724390.1_SPIKE-721-735 SVTTEILPVSMTKTS WP_003401149.1 BCG 8 87.5 VTTEILPV VTAEILPV BNN[-0.5:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9013_0361[87.5:VTTEILPI] HU:NP_056972.1[62.5:LAAEIMPV] MB:HMPREF0591_3253[100.0:VTAEILPV] 95 YP_009724390.1_SPIKE-757-771 GSFCTQLNRALTGIA WP_011799079.1 BCG 8 87.5 LNRALTGI LGRALTGI BNN[-0.5:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_004314.6[75.0:LNKELTGI] MB:HMPREF1252_0461[87.5:INRALTGI] HU:XP_016866098.1[75.0:LGRAMTGL] MB:HMPREF9944_01723[87.5:LGRALTGV] 96 YP_009724390.1_SPIKE-765-779 RALTGIAVEQDKNTQ WP_011799079.1 BCG 8 87.5 RALTGIAV RALTGIRV BNN[-0.6:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_776175.2[62.5:KSMTGIAV] MB:BACPLE_01887[87.5:RALTGIAL] HU:XP_016858491.1[62.5:RMMTGLRV] MB:BSBG_01213[75.0:RALTGLRI] 97 YP_009724390.1_SPIKE-821-835 LLFNKVTLADAGFIK WP_003412309.1 BCG 8 87.5 VTLADAGF VTLADGGF BNN[0.2:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0072_0866[87.5:ITLADAGF] HU:NO[NO] MB:HMPREF1016_02488[100.0:VTLADGGF] 98 YP_009724390.1_SPIKE-861-875 LPPLLTDEMIAQYTS WP_010950802.1 BCG 8 87.5 LPPLLTDE LPPGLTDE BYY[1.3:1.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0634_0591[100.0:LPPLLTDE] HU:XP_011533148.1[87.5:LPPGLTKE] MB:HMPREF1308_05104[87.5:LPPGLADE] 99 YP_009724390.1_SPIKE-1193-1207LNESLIDLQELGKYE WP_003900059.1 BCG 8 87.5 LNESLIDL LNEILIDL BNN[-1.7:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_024307215.1[62.5:LNQALLDL] MB:DORLON_02004[87.5:LNENLIDL] HU:NP_149015.2[75.0:LGEVLIDL] MB:HMPREF0591_1775[87.5:LNEILVDL] 100 YP_009725300_NSP4-333-347 PVYSFLPGVYSVIYL WP_003899324.1 BCG 10 80.0 LPGVYSVIYL LGGVYSDIYL BNN[-0.4:-0.9] HLAI[NONE] HLAII[NONE] HU:NP_060360.3[60.0:LPGVYEVLF] MB:COPEUT_02385[80.0:PGVYSSIYL] HU:NP_597709.3[70.0:LGGHYADSYL] MB:HMPREF0591_5514[100.0:LGGVYSDIYL] 101 YP_009725300_NSP4-141-155 EYTDFATSACVLAAE WP_003406304.1 BCG 9 88.9 ATSACVLAA ATSARVLAA BNN[-0.3:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_114171.2[66.7:GTSACLVAA] MB:HMPREF0870_00778[77.8:TSACVLSA] HU:NP_001265429.1[88.9:GTSARVLAA] MB:NO[NO] 102 YP_009725300_NSP4-369-383 FTPLVPFWITIAYII WP_003420610.1 BCG 9 88.9 LVPFWITIA LGPFWITIA BNN[-1.0:-1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0004_5222[66.7:VTPFWITVA] HU:NO[NO] MB:RHOER0001_5024[100.0:LGPFWITIA] 103 YP_009725300_NSP4-281-295 SASIVAGGIVAIVVT WP_003419287.1 BCG 8 87.5 GIVAIVVT GAVAIVVT BNN[-1.0:-1.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 104 YP_009725300_NSP4-349-363 LTFYLTNDVSFLAHI WP_011799375.1 BCG 8 87.5 TNDVSFLA TNDYSFLA BNN[-0.2:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF5175_00880[87.5:TNDVRFLA] HU:NO[NO] MB:BACCOP_00642[87.5:TNDYAFLA] 105 YP_009725300_NSP4-365-379 WMVMFTPLVPFWITI WP_003420610.1 BCG 8 87.5 LVPFWITI LGPFWITI BNN[-1.0:-1.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:RHOER0001_5024[100.0:LGPFWITI] 106 YP_009724397.2_NP-45-59 LPNNTASWFTALTQH WP_003411442.1 BCG 8 87.5 SWFTALTQ SSFTALTQ BNN[-0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_065127.5[62.5:TWFSYLTQ] MB:HMPREF1372_01660[87.5:SWGTALTQ] HU:NP_055640.2[87.5:SSFTALLQ] MB:NO[NO] 107 YP_009724397.2_NP-81-95 DDQIGYYRRATRRIR WP_003902872.1 BCG 8 87.5 RRATRRIR RRADRRIR BNN[0.2:0.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0058_1763[87.5:RRATRKIR] HU:NP_001269883.1[62.5:KQADRRIK] MB:HMPREF0975_01137[75.0:RRGDRRLR] 108 YP_009724397.2_NP-209-223 RMAGNGGDAALALLL WP_003905434.1 BCG 8 87.5 GDAALALL GDEALALL BNN[-0.5:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_011537846.1[75.0:GDLALALM] MB:HMPREF1075_02957[100.0:GDAALALL] HU:NO[NO] MB:HMPREF9551_00826[87.5:GDEAVALL] 109 YP_009724397.2_NP-385-399 RQKKQQTVTLLPAAD WP_003406618.1 BCG 8 87.5 QTVTLLPA QTVTLLRA BNN[-1.0:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_005521.1[75.0:QTVTLIPG] MB:HMPREF0322_02691[87.5:QTVTILPA] HU:NO[NO] MB:HMPREF0591_5227[100.0:QTVTLLRA] 110 YP_009725305_NSP9-97-111 LNRGMVLGSLAATVR WP_011799272.1 BCG 10 80.0 GMVLGSLAAT GMVMGNLAAT BNN[-0.5:-0.6] HLAI[HLA-A*02:01] HLAII[NONE] HU:NP_955450.2[60.0:MVVGALAAS] MB:HWAG_00584[80.0:GMALGSLAA] HU:NP_892007.1[60.0:LVKGNIAAT] MB:HMPREF1486_04126[100.0:GMVMGNLAAT] 111 YP_009725305_NSP9-97-111 LNRGMVLGSLAATVR WP_003411189.1 BCG 9 88.9 VLGSLAATV VLGGLAATV BNN[-0.5:-0.6] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*09:01, HLA-DRB1*12:01, HLA-DRB1*13:02] HU:NP_066008.2[77.8:LGSLVATV] MB:HMPREF9997_00770[88.9:VLGELAATV] HU:NP_001182533.1[77.8:VLGGVATTV] MB:HMPREF0183_1630[88.9:VLGGLASTV] 112 YP_009725305_NSP9-33-47 NTTKGGRFVLALLSD WP_011799278.1 BCG 8 87.5 GGRFVLAL GGRFVMAL BNN[-1.2:-1.4] HLAI[NONE] HLAII[NONE] HU:XP_011510519.1[87.5:GGRIVLAL] MB:HMPREF0183_0029[87.5:GGRFVLSL] HU:XP_011508974.1[75.0:GARFLMAL] MB:COLINT_03373[87.5:GGRYVMAL] 113 YP_009725305_NSP9-53-67 WARFPKSDGTGTIYT WP_003911953.1 BCG 8 87.5 PKSDGTGT PKSDRTGT BYY[1.8:2.2] HLAI[NONE] HLAII[NONE] HU:XP_005265428.1[75.0:PRSPGTGT] MB:HMPREF1168_03000[87.5:PKADGTGT] HU:NO[NO] MB:HMPREF9440_00249[100.0:PKSDRTGT] 114 YP_009725309_35EXON-113-127 TGVNLVAVPTGYVDT WP_003419825.1 BCG 10 80.0 TGVNLVAVPT TGVQLVDVPT BNN[-0.0:-0.3] HLAI[NONE] HLAII[NONE] HU:XP_016873868.1[60.0:GTNLVKIPT] MB:HMPREF1171_01335[90.0:TGVNLVAVLT] HU:XP_016871888.1[60.0:LQLVDLPT] MB:HMPREF9238_00965[90.0:GVQLVDVPT] 115 YP_009725310_RNASE-161-175 SLNGVTLIGEAVKTQ WP_003408387.1 BCG 8 87.5 NGVTLIGE NGVTLIDE BNN[-0.3:-0.4] HLAI[NONE] HLAII[NONE] HU:XP_016870747.1[75.0:NGITLLGE] MB:HMPREF9718_00048[87.5:SGVTLIGE] HU:NP_115818.2[62.5:NGTTILDE] MB:HMPREF0591_0605[100.0:NGVTLIDE] 116 YP_009725310_RNASE-237-251 YGDFSHSQLGGLHLL WP_003899248.1 BCG 8 87.5 SQLGGLHL SQLGGLVL BNN[-0.7:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_016855593.1[75.0:TQLGRLHL] MB:NO[NO] HU:NO[NO] MB:HMPREF0591_2129[87.5:SQLGGLAL] 117 YP_009725306_NSP10-61-75 ANMDQESFGGASCCL WP_014319440.1 CDI 10 80.0 ESFGGASCCL EPFGGASTCL BYN[1.5:-0.0] HLAI[NONE] HLAII[NONE] HU:XP_011535490.1[50.0:AFGGGVCCF] MB:HMPREF9130_1261[80.0:EPFGGASTCL] HU:XP_011535322.1[50.0:PWGGSHTC] MB:HMPREF9130_1261[100.0:EPFGGASTCL] 118 YP_009725307_POL-25-39 GTSTDVVYRAFDIYN WP_004566809.1 CDI 10 80.0 TDVVYRAFDI TDVVARAFPI BNN[-0.3:-0.7] HLAI[NONE] HLAII[NONE] HU:XP_005269750.1[60.0:TDVHYRSLD] MB:HMPREF0995_05572[70.0:TDVIYRAF] HU:NP_001354734.1[60.0:TDVVLQSFP] MB:HMPREF9997_01442[80.0:TDVVQKAFPI] 119 YP_009725307_POL-137-151 GNCDTLKEILVTYNC WP_014318738.1 CDI 9 88.9 DTLKEILVT DTLKEILDT BNN[-0.3:-0.8] HLAI[NONE] HLAII[NONE] HU:NP_005751.2[66.7:DTFKELLIT] MB:HMPREF9186_00273[88.9:DTLKEILV] HU:NP_004609.1[77.8:DTLREILD] MB:HMPREF0663_10038[88.9:DTYKEILDT] 120 YP_009725307_POL-161-175 DWYDFVENPDILRVY WP_014310468.1 CDI 8 100.0 VENPDILR VENPDILR BYY[1.2:1.2] HLAI[NONE] HLAII[NONE] HU:NP_001351005.1[75.0:LENPEILR] MB:CORMATOL_01378[100.0:VENPDILR] HU:NP_001351005.1[75.0:LENPEILR] MB:CORMATOL_01378[100.0:VENPDILR] 121 YP_009725307_POL-173-187 RVYANLGERVRQALL WP_014310599.1 CDI 8 87.5 ERVRQALL EGVRQALL BNN[-0.3:-0.6] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_694578.1[75.0:EKVRQAFL] MB:CAMRE0001_1585[75.0:ERIRQALI] HU:NO[NO] MB:HMPREF1206_01817[100.0:EGVRQALL] 122 YP_009725307_POL-225-239 TTPGSGVPVVDSYYS WP_014318711.1 CDI 8 87.5 SGVPVVDS SGIPVVDS BYY[1.2:0.6] HLAI[NONE] HLAII[NONE] HU:XP_006713912.1[75.0:SGCPAVDS] MB:HMPREF1012_00298[87.5:SGVPVVDT] HU:NP_000055.2[75.0:SGIPIVTS] MB:HMPREF0156_01697[87.5:SGLPVVDS] 123 YP_009725307_POL-545-559 KYAISAKNRARTVAG WP_029589651.1 CDI 8 87.5 NRARTVAG NRARTVPG BYY[0.9:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9447_01222[87.5:NRARVVAG] HU:NP_065930.2[75.0:NRARFLPG] MB:HMPREF1215_01764[87.5:NRARTIPG] 124 YP_009725307_POL-577-591 KSIAATRGATVVIGT WP_014319369.1 CDI 8 87.5 GATVVIGT GATTVIGT BNN[0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_000435.3[62.5:GGTLVLGT] MB:NO[NO] HU:XP_016867452.1[75.0:GLTTIIGT] MB:NO[NO] 125 YP_009725307_POL-709-723 STDGNKIADKYVRNL WP_003850980.1 CDI 8 87.5 ADKYVRNL ADDYVRNL BNN[0.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0519_2712[87.5:ADKYARNL] HU:XP_016866711.1[75.0:ATDYLRNL] MB:HMPREF0400_01735[87.5:SDDYVRNL] 126 YP_009725303_NSP7-45-59 TTEAFEKMVSLLSVL WP_014316958.1 CDI 10 80.0 AFEKMVSLLS ADELMVSLLS BNN[-1.2:-1.1] HLAI[NONE] HLAII[NONE] HU:NP_085142.1[70.0:FEKLVSLL] MB:HMPREF9475_04099[70.0:AFNKMISLL] HU:NP_055592.2[70.0:QELMVALLS] MB:CORTU0001_2206[90.0:ADELMVSLQS] 127 YP_009725303_NSP7-13-27 LLSVLQQLRVESSSK WP_014317624.1 CDI 8 87.5 LQQLRVES LGQLRVES BNN[-0.4:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001094385.1[87.5:LGQLRIES] MB:NO[NO] 128 YP_009725303_NSP7-49-63 FEKMVSLLSVLLSMQ WP_014316958.1 CDI 8 87.5 EKMVSLLS ELMVSLLS BNN[-1.8:-1.1] HLAI[NONE] HLAII[NONE] HU:NP_002462.2[87.5:EKMVSLLQ] MB:NO[NO] HU:XP_005273417.1[87.5:ELMVALLS] MB:NO[NO] 129 YP_009724394.1_ORF6-5-19 VDFQVTIAEILLIIM WP_014318431.1 CDI 9 88.9 VTIAEILLI VTIAEILGI BNN[-1.1:-1.8] HLAI[HLA-A*02:01] HLAII[NONE] HU:XP_011517323.1[77.8:VDIAEILL] MB:NO[NO] HU:NP_998764.1[77.8:VTYAEVLGI] MB:HMPREF1204_02153[77.8:TVAEILGI] 130 YP_009725301_3CPR-165-179 MELPTGVHAGTDLEG WP_014303394.1 CDI 8 87.5 GVHAGTDL GVHAGTHL BNY[0.2:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0105_4290[87.5:GVHKGTDL] HU:NP_001783.2[75.0:GLHAGTML] MB:CAMGR0001_0481[87.5:GVHAGTRL] 131 YP_009725311_2ORMT-45-59 AKYTQLCQYLNTLTL WP_014302814.1 CDI 10 80.0 LCQYLNTLTL LGQYLNTLAL BNN[-0.9:-1.3] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*08:02, HLA-DRB1*15:01] HU:NP_689522.2[70.0:CQYLQTLFL] MB:HMPREF0645_0624[70.0:LCQYLNTV] HU:NP_001138462.1[60.0:GQYLNTTTI] MB:HMPREF9136_2073[80.0:LGQYLHTLYL] 132 YP_009725311_2ORMT-89-103 LPTGTLLVDSDLNDF WP_014303474.1 CDI 10 80.0 LLVDSDLNDF LLVDADLTDF BNY[-0.4:0.6] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[HLA-DRB1*03:01, HLA-DRB3*01:01] HU:NO[NO] MB:HMPREF9554_01036[70.0:LIDSDLPDF] HU:NP_065393.1[70.0:LLIDRDLTEF] MB:HMPREF0993_00132[80.0:LLVDADRTD] 133 YP_009725311_2ORMT-101-115 NDFVSDADSTLIGDC WP_003851535.1 CDI 8 87.5 DADSTLIG DVDSTLIG BNY[0.1:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:BACCOP_02288[87.5:DSDSTLIG] HU:NO[NO] MB:HMPREF0299_6434[87.5:DIDSTLIG] 134 YP_009725302_NSP6-101-115 VDTSLSGFKLKDCVM WP_014319563.1 CDI 8 87.5 LSGFKLKD LSGFKLAD BNN[-0.5:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_079485.1[75.0:LMGFKMKD] MB:HMPREF0183_0820[87.5:LSGFKLDD] HU:XP_011521167.1[75.0:LSGFGVAD] MB:NO[NO] 135 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_014306945.1 CDI 10 80.0 LQGPPGTGKS LYGPPGTGKT BYY[2.0:2.2] HLAI[HLA-A*03:01] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:NP_000457.1[100.0:LYGPPGTGKT] MB:HMPREF0380_01389[100.0:LYGPPGTGKT] 136 YP_009725308_HEL-401-415 DPAQLPAPRTLLTKG WP_072574599.1 CDI 10 80.0 QLPAPRTLLT QFPIPRTLLT BNN[-0.1:0.3] HLAI[HLA-A*23:01, HLA-A*24:02, HLA-B*07:02, HLA-B*08:01, HLA-B*35:01] HLAII[NONE] HU:NP_001182551.1[70.0:QLPSPRTSL] MB:HMPREF9331_02135[80.0:QLPAPRLLL] HU:NP_000283.1[70.0:FPISRTMLT] MB:HMPREF0290_1687[90.0:QFPIPRTVLT] 137 YP_009725308_HEL-153-167 TVREVLSDRELHLSW WP_014319514.1 CDI 9 88.9 LSDRELHLS LSDRELALS BNN[-0.2:-0.4] HLAI[HLA-A*01:01] HLAII[NONE] HU:NP_001240701.1[77.8:LADRKLHLS] MB:HMPREF9151_00730[88.9:LSDEELHLS] HU:NP_001354529.1[77.8:LSDRELPL] MB:HMPREF0724_14694[77.8:SDRELALA] 138 YP_009725308_HEL-153-167 TVREVLSDRELHLSW WP_014318922.1 CDI 8 87.5 TVREVLSD TFREVLSD BNN[-0.4:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9136_1188[87.5:TVREILSD] HU:NP_000126.2[75.0:TFREVLKE] MB:HMPREF0995_00687[87.5:TFREVLSN] 139 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_014319161.1 CDI 8 87.5 GPPGTGKS GPPGSGKS BYY[2.7:2.6] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] HU:NP_001367.2[87.5:GPPGSGKT] MB:HMPREF9547_01877[100.0:GPPGSGKS] 140 YP_009725308_HEL-289-303 SHFAIGLALYYPSAR WP_014319347.1 CDI 8 87.5 HFAIGLAL HRAIGLAL BNN[-1.1:-1.5] HLAI[HLA-B*08:01] HLAII[NONE] HU:XP_024306069.1[62.5:HFEVGLAV] MB:HOLDEFILI_03959[100.0:HFAIGLAL] HU:XP_005249039.1[62.5:HRAVGMAI] MB:HMPREF9372_2829[87.5:HRTIGLAL] 141 YP_009725308_HEL-305-319 VYTACSHAAVDALCE WP_003852120.1 CDI 8 87.5 SHAAVDAL SKAAVDAL BNN[0.2:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0103_1974[75.0:SHAAIDAM] HU:NP_001341681.1[75.0:TKAAVDSL] MB:NO[NO] 142 YP_009725308_HEL-441-455 CRRCPAEIVDTVSAL WP_014316824.1 CDI 8 87.5 EIVDTVSA EIVDTVVA BNN[-0.4:0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_000425.1[75.0:ELVDPVVA] MB:NO[NO] 143 YP_009725308_HEL-573-587 LCIMSDRDLYDKLQF WP_014319353.1 CDI 8 87.5 MSDRDLYD MSVRDLYD BNY[-0.4:1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0059_01442[75.0:VSERDLYD] HU:NO[NO] MB:HMPREF0297_0935[87.5:VSVRDLYD] 144 YP_009725297_LP-9-23 NEKTHVQLSLPVLQV WP_014318441.1 CDI 10 80.0 VQLSLPVLQV VRLVLPVLQV BNN[-1.6:-1.0] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*09:01] HU:NP_001362722.1[80.0:QLLLPVLQV] MB:HMPREF1061_01329[80.0:VQLSTPVLQ] HU:NP_612398.2[70.0:QLLLPVLQV] MB:HMPREF9004_1791[80.0:VRLILPVLGV] 145 YP_009725297_LP-21-35 LQVRDVLVRGFGDSV WP_014318862.1 CDI 10 80.0 VLVRGFGDSV VLVQGFGQSV BYN[0.6:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_072047.4[60.0:LIRGFGSS] MB:HMPREF0321_2783[80.0:VLVRGFSDS] HU:NP_061187.3[60.0:MVSGFGQSM] MB:HMPREF0204_14980[80.0:VAVNGFGQSV] 146 YP_009725297_LP-49-63 GTCGLVEVEKGVLPQ WP_014318968.1 CDI 8 87.5 VEVEKGVL VEVECGVL BNN[-0.6:-0.0] HLAI[HLA-B*40:01] HLAII[NONE] HU:XP_006712009.1[75.0:VEVTKGIL] MB:HMPREF9710_00880[87.5:VEVEQGVL] HU:NO[NO] MB:NO[NO] 147 YP_009725297_LP-81-95 HGHVMVELVAELEGI WP_003851408.1 CDI 8 87.5 LVAELEGI LVAELERI BNN[-0.9:-0.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9412_5501[87.5:LVAELEGV] HU:XP_005268701.1[75.0:LVAEIERL] MB:HMPREF1071_00333[87.5:LIAELERI] 148 YP_009724395.1_ORF7a-1-15 MKIILFLALITLATC WP_003850879.1 CDI 8 87.5 LFLALITL LALALITL BNN[-2.3:-2.7] HLAI[NONE] HLAII[NONE] HU:XP_016881223.1[75.0:LFLALVAL] MB:HMPREF0021_02790[100.0:LFLALITL] HU:NP_033720.2[75.0:LALSLITI] MB:NO[NO] 149 YP_009725298_NSP2-513-527 IIIGGAKLKALNLGE WP_014319047.1 CDI 10 80.0 AKLKALNLGE AKLTALNTGE BNN[0.1:-0.6] HLAI[NONE] HLAII[NONE] HU:XP_016857091.1[60.0:KLRTLNLGQ] MB:HMPREF9425_1259[90.0:AKLKALNLKE] HU:NP_001306584.1[70.0:ARLTFLNRGE] MB:HMPREF9064_1593[80.0:KLTALSTGE] 150 YP_009725298_NSP2-93-107 FVFPLNSIIKTIQPR WP_014318578.1 CDI 9 88.9 SIIKTIQPR SIIKTIQDR BNN[-0.3:-0.2] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[HLA-DRB1*03:01, HLA-DRB4*01:01] HU:NP_071934.3[66.7:SILKVSQPR] MB:HMPREF9998_01156[77.8:IIKTIKPR] HU:NP_005575.1[66.7:SILKTLRDR] MB:HMPREF0591_2568[100.0:SIIKTIQDR] 151 YP_009724393.1_MP-1-15 MADSNGTITVEELKK WP_014318856.1 CDI 8 87.5 NGTITVEE NGTITVDE BYY[1.4:1.2] HLAI[NONE] HLAII[NONE] HU:NP_005039.1[75.0:DGTITIEE] MB:HMPREF9008_03202[87.5:NGTITVEQ] HU:NO[NO] MB:CORMATOL_03067[100.0:NGTITVDE] 152 YP_009724393.1_MP-137-151 ELVIGAVILRGHLRI WP_014318539.1 CDI 8 87.5 LVIGAVIL LGIGAVIL BNN[-1.2:-1.8] HLAI[NONE] HLAII[NONE] HU:NP_115828.2[75.0:LVVGAVAL] MB:NO[NO] HU:NO[NO] MB:HMPREF0734_00608[87.5:LGIGAIIL] 153 YP_009724393.1_MP-177-191 SYYKLGASQRVAGDS WP_014318422.1 CDI 8 87.5 LGASQRVA LGASSRVA BYN[0.4:0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:BACFIN_04793[87.5:LGASRRVA] HU:NO[NO] MB:HMPREF1214_03627[87.5:LGAASRVA] 154 YP_009725299_NSP3-513-527 GQGLNGYTVEEAKTV WP_014318941.1 CDI 10 80.0 LNGYTVEEAK VNGMTVEEAK BYY[0.4:0.5] HLAI[NONE] HLAII[NONE] HU:NP_001246.2[80.0:LNGFDVEEAK] MB:HMPREF9282_02001[90.0:NGYTVEEAK] HU:NP_001246.2[70.0:LNGFDVEEAK] MB:CORMATOL_02836[100.0:VNGMTVEEAK] 155 YP_009725299_NSP3-61-75 VIKTLQPVSELLTPL WP_014319335.1 CDI 8 87.5 VSELLTPL VSEVLTPL BNN[-0.4:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_001093260.3[87.5:ISELLTPL] MB:HMPREF9310_02344[87.5:VNELLTPL] HU:NP_001332817.1[87.5:VEEVLTPL] MB:HMPREF9103_02980[87.5:VSEVLSPL] 156 YP_009725299_NSP3-201-215 VVQTIEVNSFSGYLK WP_014319488.1 CDI 8 87.5 VNSFSGYL VGSFSGYL BNN[-0.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9964_0835[87.5:VNEFSGYL] HU:XP_011513567.1[87.5:VGSFMGYL] MB:ATORI0001_1396[100.0:VGSFSGYL] 157 YP_009725299_NSP3-225-239 ADIVEEAKKVKPTVV WP_004566656.1 CDI 8 87.5 EAKKVKPT EAKKVAPT BYY[0.9:1.0] HLAI[NONE] HLAII[NONE] HU:NP_000330.3[62.5:EPRKVRPT] MB:HMPREF1208_01915[100.0:EAKKVKPT] HU:XP_006712718.1[75.0:ESKKVLPT] MB:COPCOM_02912[87.5:EAKKVAPS] 158 YP_009725299_NSP3-245-259 VYLKHGGGVAGALNK WP_003850857.1 CDI 8 87.5 GGGVAGAL GRGVAGAL BYY[0.4:0.6] HLAI[NONE] HLAII[NONE] HU:NP_001096640.2[75.0:GGGVMGSL] MB:NO[NO] HU:XP_005249588.1[75.0:GRGVAGPM] MB:HMPREF0308_0349[100.0:GRGVAGAL] 159 YP_009725299_NSP3-437-451 LYIDINGNLHPDSAT WP_014302140.1 CDI 8 87.5 NLHPDSAT NLHPDIAT BYY[0.4:1.2] HLAI[NONE] HLAII[NONE] HU:NP_008825.4[75.0:NKHPDFAT] MB:HMPREF0305_10149[75.0:NIHPDSAS] HU:NP_008825.4[75.0:NKHPDFAT] MB:HMPREF9475_03109[87.5:NLHPDIDT] 160 YP_009725299_NSP3-445-459 LHPDSATLVSDIDIT WP_014318660.1 CDI 8 87.5 SATLVSDI STTLVSDI BNN[-0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_056480.1[62.5:SATIVADL] MB:HMPREF0091_10074[87.5:SATLISDI] HU:NO[NO] MB:HMPREF0290_0665[100.0:STTLVSDI] 161 YP_009725299_NSP3-637-651 HGLNLEEAARYMRSL WP_014308916.1 CDI 8 87.5 LNLEEAAR LNLEGAAR BNN[0.1:0.1] HLAI[NONE] HLAII[NONE] HU:NP_055654.2[87.5:LGLEEAAR] MB:HMPREF9469_02175[87.5:LDLEEAAR] HU:NP_060549.4[87.5:LGLEGAAR] MB:NO[NO] 162 YP_009725299_NSP3-685-699 ETISLAGSYKDWSYS WP_014319099.1 CDI 8 87.5 ETISLAGS ETILLAGS BNN[-1.0:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_011526875.1[75.0:KTISLSGS] MB:NO[NO] HU:NO[NO] MB:HMPREF9718_03784[100.0:ETILLAGS] 163 YP_009725299_NSP3-849-863 IKWADNNCYLATALL WP_014317864.1 CDI 8 87.5 DNNCYLAT DNNCYLLT BNN[-0.9:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0277_1240[87.5:DNNCYLLT] HU:NO[NO] MB:HMPREF0277_1240[100.0:DNNCYLLT] 164 YP_009725299_NSP3-897-911 LAYCNKTVGELGDVR WP_014318877.1 CDI 8 87.5 TVGELGDV TGGELGDV BYY[1.0:1.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF0204_12066[87.5:TGGRLGDV] 165 YP_009725299_NSP3-1145-1159 LNGDVVAIDYKHYTP WP_014310487.1 CDI 8 87.5 LNGDVVAI LNGDLVAI BNN[-0.6:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_689596.4[62.5:LNGDLVVV] MB:BIFADO_02434[87.5:LNGDVVAM] HU:NP_689596.4[75.0:LNGDLVVV] MB:FMAG_00039[87.5:INGDLVAI] 166 YP_009725299_NSP3-1293-1307 NELSRVLGLKTLATH WP_014319225.1 CDI 8 87.5 VLGLKTLA VLGLITLA BNN[-1.8:-1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:XP_016864714.1[75.0:LLGIITLA] MB:HMPREF0045_01755[100.0:VLGLITLA] 167 YP_009725299_NSP3-1337-1351 NIVTRCLNRVCTNYM WP_014318590.1 CDI 8 87.5 RCLNRVCT RCLNRVTT BNN[-0.6:-1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1168_00074[100.0:RCLNRVCT] HU:NO[NO] MB:HMPREF1168_00074[87.5:RCLNRVCT] 168 YP_009725299_NSP3-1793-1807 TLVATAEAELAKNVS WP_014318656.1 CDI 8 87.5 TAEAELAK TAEAELHK BYY[0.4:0.5] HLAI[NONE] HLAII[NONE] HU:NP_001166028.1[75.0:TAEAELSR] MB:HMPREF9709_00208[87.5:TAEAEIAK] HU:NP_001166945.1[75.0:TAEAECHR] MB:HMPREF1059_02025[75.0:SAEAQLHK] 169 YP_009725299_NSP3-1933-1945 VNVVTTKIALKGG WP_003851088.1 CDI 8 87.5 VVTTKIAL VVTTIIAL BNN[-1.4:-0.7] HLAI[NONE] HLAII[NONE] HU:XP_016870058.1[75.0:LVTSKIAL] MB:NO[NO] HU:NO[NO] MB:NO[NO] 170 YP_009725304_NSP8-149-163 YASALWEIQQVVDAD WP_014310521.1 CDI 8 87.5 EIQQVVDA EIQAVVDA BNN[-0.2:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_016868466.1[75.0:EIQGVIDA] MB:HMPREF9020_01302[87.5:EIQQIVDA] HU:XP_016858338.1[75.0:EMQAVIDA] MB:HMPREF0299_6644[100.0:EIQAVVDA] 171 YP_009725304_NSP8-165-179 KIVQLSEISMDNSPN WP_014319112.1 CDI 8 87.5 LSEISMDN LSEIGMDN BYN[0.9:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9446_03830[87.5:LGEISMDN] HU:XP_011533233.1[62.5:LTEFGMQN] MB:HMPREF0444_0764[87.5:LEEIGMDN] 172 YP_009724390.1_SPIKE-61-75 NVTWFHAIHVSGTNG WP_014319258.1 CDI 11 81.8 FHAIHVSGTNG FPAIHVAGTNG BNN[0.2:-0.0] HLAI[NONE] HLAII[NONE] HU:XP_011531337.1[54.5:LHRIHVDGSSG] MB:HMPREF0574_1597[72.7:FHSIHITGTNG] HU:XP_011541223.1[54.5:FPPVHVAG] MB:HMPREF9997_01947[100.0:FPAIHVAGTNG] 173 YP_009724390.1_SPIKE-681-695 PRRARSVASQSIIAY WP_014318604.1 CDI 10 80.0 PRRARSVASQ PRRAHSVAAQ BYY[0.5:0.6] HLAI[NONE] HLAII[NONE] HU:NP_001029.1[80.0:RRARSVAS] MB:HMPREF9431_01483[70.0:PRRAHSIAAQ] HU:NP_001281261.1[70.0:PTRSHTVAAQ] MB:HMPREF0645_0264[90.0:PRRAHSIAAQ] 174 YP_009724390.1_SPIKE-1125-1139NCDVVIGIVNNTVYD WP_014316729.1 CDI 10 80.0 VVIGIVNNTV VVIGIVMMTV BNN[-1.9:-0.8] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*08:02, HLA-DRB1*15:01] HU:NP_036558.3[50.0:LAVGLVDNTV] MB:HMPREF9420_0531[70.0:VIGIINNT] HU:NP_001354490.1[60.0:LIGIIMETV] MB:HMPREF1531_00486[80.0:VIGIVMMTM] 175 YP_009724390.1_SPIKE-161-175 SSANNCTFEYVSQPF WP_041740449.1 CDI 8 87.5 FEYVSQPF FEYVSQNF BNN[-0.3:0.0] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:XP_005272478.1[62.5:FQYLLQPF] MB:HMPREF9554_02686[75.0:FQYISQPF] HU:NP_006780.1[87.5:FEYVWQNF] MB:HMPREF0308_1651[87.5:FEYVSENF] 176 YP_009724390.1_SPIKE-205-219 SKHTPINLVRDLPQG WP_014319456.1 CDI 8 87.5 LVRDLPQG LVRDRPQG BYN[0.9:0.2] HLAI[NONE] HLAII[NONE] HU:XP_016879708.1[75.0:LVRDVPHG] MB:HMPREF9970_0934[87.5:LIRDLPQG] HU:XP_011514257.1[75.0:LVKDRPYG] MB:HMPREF9732_01651[75.0:LIRDRPSG] 177 YP_009724390.1_SPIKE-221-235 SALEPLVDLPIGINI WP_014319153.1 CDI 8 87.5 PLVDLPIG PLVNLPIG BNN[-0.4:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_036608.1[75.0:PLLDLPAG] MB:HMPREF9689_02983[87.5:PLADLPIG] HU:NO[NO] MB:HMPREF9997_01466[100.0:PLVNLPIG] 178 YP_009724390.1_SPIKE-953-967 NQNAQALNTLVKQLS WP_010935253.1 CDI 8 87.5 ALNTLVKQ ALNGLVKQ BNN[-0.6:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_001138453.1[75.0:SLNTLLKQ] MB:NO[NO] HU:NO[NO] MB:HMPREF9296_1291[87.5:ALNGLVKR] 179 YP_009724390.1_SPIKE-1089-1103FPREGVFVSNGTHWF WP_014306933.1 CDI 8 87.5 EGVFVSNG DGVFVSNG BNN[-0.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_004332.2[75.0:EGLFLSNG] MB:HMPREF9997_01255[100.0:EGVFVSNG] HU:NP_005752.1[75.0:DGVFVASG] MB:HMPREF9719_00741[100.0:DGVFVSNG] 180 YP_009724390.1_SPIKE-1161-1175SPDVDLGDISGINAS WP_010934839.1 CDI 8 87.5 LGDISGIN LGDISGLN BNY[0.1:0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9310_01986[87.5:LGDISGLN] HU:NP_001269318.1[75.0:LGDTEGLN] MB:HMPREF9310_01986[100.0:LGDISGLN] 181 YP_009724390.1_SPIKE-1185-1199RLNEVAKNLNESLID WP_010935562.1 CDI 8 87.5 AKNLNESL AKNLPESL BYY[0.6:0.5] HLAI[NONE] HLAII[NONE] HU:NP_004527.2[87.5:AKNLNEQL] MB:HMPREF0793_1615[87.5:AKNINESL] HU:NP_001238935.1[62.5:SKNLPQSV] MB:HMPREF0305_10810[100.0:AKNLPESL] 182 YP_009724390.1_SPIKE-1217-1231WLGFIAGLIAIVMVT WP_014318736.1 CDI 8 87.5 IAGLIAIV IGGLIAIV BNN[-1.5:-1.7] HLAI[NONE] HLAII[NONE] HU:NP_207837.2[75.0:IGGLIAVV] MB:NO[NO] HU:NP_207837.2[87.5:IGGLIAVV] MB:HMPREF9099_01906[87.5:IGGLIAVV] 183 YP_009725300_NSP4-173-187 TNVLEGSVAYESLRP WP_014303645.1 CDI 10 80.0 EGSVAYESLR DGSVAMESLR BNN[0.1:0.3] HLAI[HLA-A*11:01] HLAII[NONE] HU:NP_056471.1[70.0:GSSGYESLR] MB:HMPREF9019_1535[80.0:EGSVNYERLR] HU:XP_011523846.1[70.0:GSVALETLR] MB:HMPREF1206_01856[90.0:DGSIAMESLR] 184 YP_009725300_NSP4-141-155 EYTDFATSACVLAAE WP_014318603.1 CDI 9 87.5 ATSACVLAA ATSALVLAA BNN[-1.0:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_114171.2[66.7:GTSACLVAA] MB:HMPREF0870_00778[77.8:TSACVLSA] HU:NP_741983.2[77.8:ATSPLVLA] MB:NO[NO] 185 YP_009725300_NSP4-205-219 YLEGSVRVVTTFDSE WP_010934320.1 CDI 8 87.5 VVTTFDSE VLTTFDSE BNN[-0.0:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1097_03627[87.5:VVTPFDSE] HU:NO[NO] MB:HMPREF1318_2584[87.5:VLTTFDEE] 186 YP_009725300_NSP4-273-287 QPIGALDISASIVAG WP_014316612.1 CDI 8 87.5 LDISASIV LGISASIV BNN[-0.6:-0.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_000929.1[62.5:LGVCASII] MB:HMPREF9709_01197[87.5:LGISASVV] 187 YP_009725300_NSP4-289-303 IVAIVVTCLAYYFMR WP_014319384.1 CDI 8 87.5 IVAIVVTC IVAIVITC BNN[-2.0:-1.8] HLAI[NONE] HLAII[NONE] HU:NP_851322.3[75.0:LVAISVTC] MB:HMPREF9186_00535[87.5:IVAIVFTC] HU:XP_005268094.1[75.0:IVAFVIVC] MB:HMPREF9186_00535[87.5:IVAIVFTC] 188 YP_009725300_NSP4-365-379 WMVMFTPLVPFWITI WP_010935077.1 CDI 8 87.5 LVPFWITI LVPWWITI BNN[-1.3:-1.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF0880_03273[62.5:FVPWWVTL] 189 YP_009724397.2_NP-353-367 LNKHIDAYKTFPPTE WP_014318473.1 CDI 10 80.0 DAYKTFPPTE DAVKTFNPTE BYY[0.8:1.2] HLAI[NONE] HLAII[NONE] HU:XP_011520656.1[60.0:DAYPRFPPIQ] MB:HMPREF0766_12760[70.0:DASKTFPP] HU:XP_011534752.1[50.0:DSVETYNP] MB:HMPREF0291_10493[90.0:DAVKTYNPTE] 190 YP_009725305_NSP9-33-47 NTTKGGRFVLALLSD WP_014316420.1 CDI 8 87.5 RFVLALLS RWVLALLS BNN[-2.1:-2.3] HLAI[NONE] HLAII[NONE] HU:NP_001028225.1[75.0:RFLLGLLS] MB:NO[NO] HU:NO[NO] MB:HMPREF0494_1071[87.5:RWVLRLLS] 191 YP_009725305_NSP9-69-83 LEPPCRFVTDTPKGP WP_014319320.1 CDI 8 87.5 VTDTPKGP VTDTPDGP BYY[2.3:2.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:CLOSTHATH_06438[87.5:VKDTPKGP] HU:NO[NO] MB:RHOER0001_0685[100.0:VTDTPDGP] 192 YP_009725305_NSP9-97-111 LNRGMVLGSLAATVR WP_014318679.1 CDI 8 87.5 VLGSLAAT VLGSVAAT BNN[-0.1:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 193 YP_009725309_35EXON-105-119 LPLQLGFSTGVNLVA WP_021334931.1 CDI 8 87.5 GFSTGVNL GFSTGVHL BNY[-0.1:0.5] HLAI[NONE] HLAII[NONE] HU:NP_001265874.1[75.0:GFGTGVNV] MB:HMPREF9444_00887[87.5:GFSTGVNV] HU:NO[NO] MB:HMPREF9451_00822[87.5:GFSTGAHL] 194 YP_009725309_35EXON-129-143 NNTDFSRVSAKPPPG WP_014310332.1 CDI 8 87.5 DFSRVSAK DFSRDSAK BYN[1.0:0.1] HLAI[NONE] HLAII[NONE] HU:XP_011532929.1[75.0:DYSRPSAK] MB:HMPREF1004_01294[87.5:DFQRVSAK] HU:XP_011532929.1[75.0:DYSRPSAK] MB:BIFPSEUDO_03848[100.0:DFSRDSAK] 195 YP_009724396.1_ORF8-53-67 KSAPLIELCVDEAGS WP_014310407.1 CDI 11 81.8 PLIELCVDEAG PLIDLIVDEAG BNN[-0.6:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_079330.2[63.6:LELCVDAAG] MB:HMPREF9701_06068[63.6:FIEICLDEAG] HU:NP_000252.1[72.7:IDLAVDEAG] MB:BIFCAT_01097[81.8:PLVDLIVDHAG] 196 YP_009725310_RNASE-101-115 VCSMTDIAKKPTETI WP_014310154.1 CDI 8 87.5 AKKPTETI AKKPGETI BYY[1.6:1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:OFBG_01491[75.0:GKKPTETM] HU:NO[NO] MB:HMPREF0308_0996[75.0:AKKPGEAV] 197 YP_009724391.1_ORF3a-41-55 LPFGWLIVGVALLAV WP_010930154.1 BPE 9 88.9 LIVGVALLA LIVGLALLA BNN[-2.1:-1.8] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*08:02, HLA-DRB1*15:01] HU:NP_002204.2[77.8:LLVGLALLA] MB:HMPREF1154_1496[88.9:LLVGVALLA] HU:NP_002204.2[88.9:LLVGLALLA] MB:BACCELL_04462[77.8:LVVGLALIA] 198 YP_009724391.1_ORF3a-37-51 IQASLPFGWLIVGVA WP_010931229.1 BPE 8 87.5 FGWLIVGV FGVLIVGV BNN[-1.9:-1.8] HLAI[NONE] HLAII[NONE] HU:XP_024303802.1[75.0:FGWLLIGV] MB:HMPREF9412_3626[87.5:FGWKIVGV] HU:XP_016871062.1[62.5:FGIVIVGM] MB:HMPREF9141_0704[87.5:FGALIVGV] 199 YP_009724391.1_ORF3a-89-103 TVYSHLLLVAAGLEA WP_010931563.1 BPE 8 87.5 LLLVAAGL LLLMAAGL BNN[-1.9:-1.8] HLAI[NONE] HLAII[NONE] HU:XP_011529279.1[87.5:MLLVAAGL] MB:HMPREF9240_00566[100.0:LLLVAAGL] HU:NO[NO] MB:HMPREF1060_00149[87.5:MLLMAAGL] 200 YP_009725307_POL-749-763 LRKHFSMMILSDDAV WP_010931652.1 BPE 10 80.0 HFSMMILSDD HFSMMILGAD BNN[-1.4:-1.3] HLAI[NONE] HLAII[HLA-DRB1*04:05, HLA-DRB4*01:01] HU:XP_011531300.1[50.0:HFAMMVIS] MB:HMPREF9538_03047[80.0:HFSMMILS] HU:NP_955806.1[50.0:YFSMLLVGKD] MB:HMPREF0204_13437[80.0:HFSRMILGED] 201 YP_009725307_POL-53-67 CCRFQEKDEDDNLID WP_010931302.1 BPE 8 87.5 DEDDNLID DEEDNLID BYY[0.8:0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001358208.1[62.5:DEEEDLLD] MB:HMPREF1140_1083[87.5:DEEDNVID] 202 YP_009725307_POL-577-591 KSIAATRGATVVIGT WP_003813819.1 BPE 8 87.5 ATRGATVV AARGATVV BNY[0.3:0.4] HLAI[NONE] HLAII[NONE] HU:NP_001362453.1[87.5:ATQGATVV] MB:NO[NO] HU:NO[NO] MB:HMPREF9010_01892[87.5:AARGATIV] 203 YP_009725307_POL-849-863 KTDGTLMIERFVSLA WP_033446272.1 BPE 8 87.5 IERFVSLA IERTVSLA BNN[-0.4:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_001352957.1[75.0:IEKFLSLA] MB:HMPREF9710_00060[87.5:VERFVSLA] HU:NP_001317693.1[75.0:MERTVSLS] MB:HMPREF1021_01561[75.0:VERTISLA] 204 YP_009725307_POL-881-895 FHLYLQYIRKLHDEL WP_003811203.1 BPE 8 87.5 IRKLHDEL IRKLEDEL BNN[-0.1:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_060478.3[62.5:VRKLHDSV] MB:HMPREF0548_0086[87.5:IKKLHDEL] HU:NO[NO] MB:HMPREF0004_3567[100.0:IRKLEDEL] 205 YP_009725303_NSP7-5-19 DVKCTSVVLLSVLQQ WP_023853448.1 BPE 8 87.5 SVVLLSVL SVVLLSPL BNN[-1.4:-2.2] HLAI[NONE] HLAII[NONE] HU:XP_016874764.1[75.0:NVILLSVL] MB:NO[NO] HU:NO[NO] MB:HMPREF0004_2421[100.0:SVVLLSPL] 206 YP_009725303_NSP7-57-71 SVLLSMQGAVDINKL WP_003811709.1 BPE 8 87.5 GAVDINKL GAVRINKL BNN[-0.6:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_016873478.1[75.0:GALDISKL] MB:HMPREF9444_00292[87.5:GTVDINKL] HU:NO[NO] MB:HMPREF1242_0326[100.0:GAVRINKL] 207 YP_009724394.1_ORF6-45-59 TENKYSQLDEEQPME WP_010930054.1 BPE 8 87.5 YSQLDEEQ YSQLREEQ BYY[0.4:0.8] HLAI[NONE] HLAII[NONE] HU:NP_060360.3[87.5:YSQQDEEQ] MB:HMPREF1007_02540[87.5:YPQLDEEQ] HU:XP_016881193.1[62.5:YSELKEQQ] MB:HMPREF1390_03940[87.5:YEQLREEQ] 208 YP_009725301_3CPR-249-263 ILGPLSAQTGIAVLD WP_010930949.1 BPE 10 80.0 LSAQTGIAVL VSAATGIAVL BNN[-0.2:-0.0] HLAI[HLA-B*07:02, HLA-B*08:01, HLA-B*35:01] HLAII[HLA-DRB1*09:01] HU:XP_011509557.1[70.0:SAQTPIAVI] MB:HMPREF0972_01259[80.0:LSSQTGIAV] HU:XP_011519981.1[70.0:SAATGVFVL] MB:HMPREF0557_02890[100.0:VSAATGIAVL] 209 YP_009725311_2ORMT-17-31 MQRMLLEKCDLQNYG WP_010930201.1 BPE 10 80.0 MQRMLLEKCD MQRMLDEQCD BNN[-0.2:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_006420.1[70.0:QRKLLEKC] MB:HMPREF0397_0445[70.0:RMLIEKCD] HU:XP_016860164.1[60.0:LQRMVSEQC] MB:HMPREF0005_00599[80.0:MRRMLDEQRD] 210 YP_009725311_2ORMT-261-275 SLKEGQINDMILSLL WP_010930947.1 BPE 9 88.9 INDMILSLL INAMILSLL BNN[-2.1:-1.8] HLAI[NONE] HLAII[NONE] HU:XP_005270743.1[66.7:NDMVLCLL] MB:HMPREF9696_03054[88.9:INTMILSLL] HU:NP_001317429.1[77.8:INAMLLSVL] MB:HMPREF9440_00200[100.0:INAMILSLL] 211 YP_009725311_2ORMT-85-99 LRQWLPTGTLLVDSD WP_010930867.1 BPE 8 87.5 TGTLLVDS TGTILVDS BNN[-0.5:-0.6] HLAI[NONE] HLAII[NONE] HU:XP_011516365.1[75.0:TGTFLVDN] MB:BFAG_02795[75.0:TGSLLIDS] HU:XP_011516365.1[75.0:TGTFLVDN] MB:HMPREF0308_1127[87.5:TGTVLVDS] 212 YP_009725311_2ORMT-89-103 LPTGTLLVDSDLNDF WP_010931087.1 BPE 8 87.5 TLLVDSDL TLLADSDL BNN[-0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:XP_016866433.1[75.0:TVLVDTDL] MB:HMPREF0542_11644[100.0:TLLVDSDL] HU:XP_011512728.1[87.5:TLLKDSDL] MB:HMPREF9332_01348[87.5:TLLADTDL] 213 YP_009725311_2ORMT-153-167 ICGFIQQKLALGGSV WP_010931103.1 BPE 8 87.5 QKLALGGS QGLALGGS BNN[0.0:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_011517184.1[75.0:QRLDLGGS] MB:HMP0015_1627[87.5:QKLALGGT] HU:NP_055236.1[87.5:QGLAFGGS] MB:HMPREF1119_1491[100.0:QGLALGGS] 214 YP_009725302_NSP6-273-287 IKLLGVGGKPCIKVA WP_010931409.1 BPE 10 80.0 LLGVGGKPCI LLAVGGKPLI BYN[0.7:0.2] HLAI[NONE] HLAII[NONE] HU:NP_009186.1[60.0:LSVGGAPC] MB:HMPREF9710_01119[60.0:LGAGGRPC] HU:XP_016858234.1[80.0:LLPVGNKPLI] MB:HMPREF1169_00433[100.0:LLAVGGKPLI] 215 YP_009725302_NSP6-97-111 WLDMVDTSLSGFKLK WP_010930616.1 BPE 8 87.5 SLSGFKLK SLSGGKLK BYN[0.5:-0.5] HLAI[HLA-A*03:01] HLAII[NONE] HU:NO[NO] MB:HMPREF9444_01379[87.5:SLSGFELK] HU:NO[NO] MB:HMPREF1181_00974[87.5:SLSGGQLK] 216 YP_009725302_NSP6-109-123 KLKDCVMYASAVVLL WP_010931191.1 BPE 8 87.5 YASAVVLL YASASVLL BNN[-0.6:-1.3] HLAI[HLA-A*23:01, HLA-A*24:02] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_569157.2[75.0:YSSASVKL] MB:NO[NO] 217 YP_009725302_NSP6-157-171 ALDQAISMWALIISV WP_010930789.1 BPE 8 87.5 MWALIISV MRALIISV BNN[-1.9:-2.2] HLAI[NONE] HLAII[NONE] HU:NP_005473.1[75.0:LWALIIMV] MB:HMPREF0297_0628[75.0:MWKLLISV] HU:NO[NO] MB:HMPREF0995_01135[87.5:MRALIVSV] 218 YP_009725302_NSP6-265-279 SIDAFKLNIKLLGVG WP_010931014.1 BPE 8 87.5 LNIKLLGV LNIKGLGV BNN[-0.7:-1.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_056169.1[62.5:INIMGIGV] MB:CLOSTASPAR_01276[87.5:LNVKGLGV] 219 YP_009725302_NSP6-269-283 FKLNIKLLGVGGKPC WP_010931409.1 BPE 8 87.5 LLGVGGKP LLAVGGKP BNY[0.1:0.4] HLAI[NONE] HLAII[NONE] HU:XP_011520875.1[75.0:VLGAGGKP] MB:HMPREF9954_0044[87.5:LLGAGGKP] HU:XP_005249982.1[75.0:LLALGGNP] MB:HMPREF0556_11850[87.5:LLAIGGKP] 220 YP_009725308_HEL-245-259 HYVRITGLYPTLNIS WP_023853656.1 BPE 10 80.0 TGLYPTLNIS TGLQPTLAIS BNN[0.2:-0.1] HLAI[NONE] HLAII[NONE] HU:NP_006062.1[60.0:FYPTLNVS] MB:HMPREF9997_01970[80.0:TGLYPTWDIS] HU:NP_001362582.1[70.0:TGFQPSLASS] MB:HMPREF9448_00951[70.0:TGLRPTLAV] 221 YP_009725308_HEL-397-411 VYIGDPAQLPAPRTL WP_010929996.1 BPE 10 80.0 GDPAQLPAPR GDKAQLPALR BYY[0.5:1.6] HLAI[NONE] HLAII[NONE] HU:XP_024305467.1[70.0:EPATLPAPR] MB:HMPREF9442_00234[70.0:GDPARLPHP] HU:NP_001400.3[70.0:GDKCQSPCLR] MB:HMPREF1307_01861[80.0:DKTQLPALR] 222 YP_009725308_HEL-477-491 KGVITHDVSSAINRP WP_010931603.1 BPE 9 88.9 ITHDVSSAI ITHDVSEAI BNN[0.2:0.1] HLAI[NONE] HLAII[HLA-DRB1*03:01, HLA-DRB1*04:01, HLA-DRB1*13:02, HLA-DRB3*01:01] HU:NO[NO] MB:HMPREF0987_02683[77.8:ITHDISEAI] HU:NP_005079.2[66.7:IVHDTSEAV] MB:HMPREF9289_1519[88.9:VTHDVSEAI] 223 YP_009725308_HEL-273-287 GMQKYSTLQGPPGTG WP_010930312.1 BPE 8 87.5 LQGPPGTG LQGPPGAG BYY[2.2:2.3] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF1068_02855[100.0:LQGPPGTG] HU:XP_016872154.1[87.5:LMGPPGAG] MB:HMPREF1420_00140[87.5:IQGPPGAG] 224 YP_009725308_HEL-393-407 AKHYVYIGDPAQLPA WP_010929996.1 BPE 8 87.5 GDPAQLPA GDKAQLPA BYY[1.0:1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:ALIPUT_01910[87.5:GDPANLPA] HU:NP_000812.2[75.0:GEKMQLPA] MB:NO[NO] 225 YP_009725308_HEL-473-487 KMFYKGVITHDVSSA WP_010931603.1 BPE 8 87.5 ITHDVSSA ITHDVSEA BYY[0.4:0.4] HLAI[NONE] HLAII[NONE] HU:NP_001864.1[75.0:IDHDVTSA] MB:HMPREF9709_00615[87.5:ITHDVSSS] HU:NP_005079.2[75.0:IVHDTSEA] MB:HMPREF9413_5787[87.5:VTHDVSEA] 226 YP_009725308_HEL-561-575 FNVAITRAKVGILCI WP_010930695.1 BPE 8 87.5 TRAKVGIL TGAKVGIL BNN[-0.1:-0.4] HLAI[HLA-B*08:01] HLAII[NONE] HU:NO[NO] MB:HMPREF1033_01635[87.5:TRAEVGIL] HU:NP_055935.4[62.5:TGASVGVF] MB:HMPREF0321_0360[100.0:TGAKVGIL] 227 YP_009725297_LP-117-131 AYRKVLLRKNGNKGA WP_010930297.1 BPE 8 87.5 LRKNGNKG LRENGNKG BYY[1.2:1.1] HLAI[NONE] HLAII[NONE] HU:NP_001317569.1[62.5:LKKNGDRG] MB:HMPREF0357_10897[87.5:LRKQGNKG] HU:NO[NO] MB:HMPREF9702_05385[87.5:FRENGNKG] 228 YP_009724395.1_ORF7a-97-111 YSPIFLIVAAIVFIT WP_003813147.1 BPE 8 87.5 LIVAAIVF LIVAAIVW BNN[-1.9:-2.1] HLAI[NONE] HLAII[NONE] HU:XP_016876048.1[75.0:MLVAAIVF] MB:HMPREF0204_10425[87.5:LIIAAIVF] HU:NP_647537.1[75.0:LLVAAVVW] MB:HMPREF1021_00168[75.0:LIVASIIW] 229 YP_009725318.1_ORF7b-5-19 SLIDFYLCFLAFLLF WP_003814856.1 BPE 8 87.5 CFLAFLLF AFLAFLLF BNN[-3.0:-3.2] HLAI[NONE] HLAII[NONE] HU:NP_775323.1[75.0:CVLVFLLF] MB:HMPREF9412_0676[75.0:CFVGFLLF] HU:NO[NO] MB:HMPREF1181_01008[87.5:SFLAFLLF] 230 YP_009725298_NSP2-581-595 GDLQPLEQPTSEAVE WP_003820806.1 BPE 10 80.0 LEQPTSEAVE LEQPTSGAVR BYY[1.2:1.3] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:XP_011541515.1[60.0:FEQPSSEA] MB:HRAG_00214[80.0:LENPTSEAIE] HU:XP_011531019.1[70.0:LQQPISGAV] MB:HMPREF1006_00385[90.0:LEQPTAGAVR] 231 YP_009725298_NSP2-17-31 PLECIKDLLARAGKA WP_010930242.1 BPE 8 87.5 LLARAGKA LLARAGVA BNN[-0.5:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_694972.3[62.5:MIARAGRA] MB:ANACAC_00182[100.0:LLARAGKA] HU:NP_001161819.1[87.5:LLARAGVS] MB:CW1_0202[87.5:LLARAGVS] 232 YP_009725298_NSP2-69-83 YELQTPFEIKLAKKF WP_003816876.1 BPE 8 87.5 TPFEIKLA SPFEIKLA BNN[-0.4:-0.4] HLAI[HLA-B*07:02, HLA-B*35:01] HLAII[NONE] HU:XP_016873415.1[62.5:TPFEVKVG] MB:HMPREF0014_01629[87.5:TPFQIKLA] HU:XP_016865561.1[62.5:SPFELKIG] MB:HMPREF1093_04474[75.0:SPFEVKIA] 233 YP_009725298_NSP2-349-363 ILSPLYAFASEAARV WP_010931677.1 BPE 8 87.5 FASEAARV FASELARV BNY[-0.5:1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001363498.1[87.5:FASELASV] MB:HMPREF0848_01454[100.0:FASELARV] 234 YP_009725298_NSP2-453-467 EKFKEGVEFLRDGWE WP_019248041.1 BPE 8 87.5 GVEFLRDG GVEFLRFG BNN[-1.2:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_001258152.2[75.0:GLEALRDG] MB:RUMHYD_03899[75.0:GIEFMRDG] HU:XP_016878921.1[62.5:GVEYMRLG] MB:RUMOBE_01410[75.0:GVEFVRYG] 235 YP_009725298_NSP2-589-603 PTSEAVEAPLVGTPV WP_010929573.1 BPE 8 87.5 PTSEAVEA PTEEAVEA BYY[1.2:1.2] HLAI[NONE] HLAII[NONE] HU:XP_011541346.1[75.0:PTSEEIEA] MB:NO[NO] HU:NO[NO] MB:HMPREF0476_1843[100.0:PTEEAVEA] 236 YP_009724393.1_MP-5-19 NGTITVEELKKLLEQ WP_010931507.1 BPE 8 87.5 TVEELKKL AVEELKKL BNN[-0.3:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_016863526.1[87.5:TVEDLKKL] MB:HMPREF9489_1246[100.0:TVEELKKL] HU:NP_996735.1[87.5:AVEEVKKL] MB:HMPREF9549_01454[87.5:AIEELKKL] 237 YP_009724393.1_MP-109-123 MWSFNPETNILLNVP WP_010931692.1 BPE 8 87.5 TNILLNVP TSILLNVP BNN[-1.2:-1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0555_1189[87.5:TNLLLNVP] HU:XP_016882399.1[62.5:TSLLVNIP] MB:HMPREF0004_0690[87.5:TAILLNVP] 238 YP_009724393.1_MP-137-151 ELVIGAVILRGHLRI WP_010930018.1 BPE 8 87.5 LVIGAVIL LVVGAVIL BNN[-1.6:-1.8] HLAI[NONE] HLAII[NONE] HU:NP_115828.2[75.0:LVVGAVAL] MB:NO[NO] HU:NP_115828.2[87.5:LVVGAVAL] MB:HMP0721_1072[87.5:LIVGAVIL] 239 YP_009725299_NSP3-249-263 HGGGVAGALNKATNN WP_003812851.1 BPE 10 80.0 GGVAGALNKA GGVAGALFAA BNY[-0.3:0.4] HLAI[HLA-A*02:01] HLAII[NONE] HU:XP_011521262.1[60.0:GVAGGLNR] MB:HMPREF9238_01675[80.0:GGVAGAIDKA] HU:NP_003934.1[70.0:GGLAGALF] MB:HMPREF1015_02625[80.0:GGLAGALFA] 240 YP_009725299_NSP3-521-535 VEEAKTVLKKCKSAF WP_003813315.1 BPE 10 80.0 KTVLKKCKSA KLVLKKAKSA BNN[-0.4:-0.3] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_077283.2[60.0:SVMKKCKAA] MB:COPEUT_02995[80.0:KTVLKKCK] HU:XP_024306346.1[60.0:ELVLRKARS] MB:HMPREF0972_02343[90.0:LVLKKAKSA] 241 YP_009725299_NSP3-565-579 EETRKLMPVCVETKA WP_010930416.1 BPE 10 80.0 TRKLMPVCVE TRKRMPVWVE BNN[-0.1:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_056016.1[60.0:TKKLMPNC] MB:CLOHYLEM_05359[70.0:TRKLIPVCL] HU:XP_011528981.1[60.0:KRSPCWVE] MB:HMPREF0004_4967[90.0:TRKKMPVWVE] 242 YP_009725299_NSP3-633-647 GYVTHGLNLEEAARY WP_010929649.1 BPE 10 80.0 HGLNLEEAAR HGPDLEEAAR BYY[1.2:0.9] HLAI[NONE] HLAII[NONE] HU:XP_011510404.1[70.0:HGLNIEESMR] MB:ERE_24230[90.0:HGLGLEEAAR] HU:NP_001308211.1[70.0:PDAEEAAR] MB:HMPREF1004_04271[80.0:GPELEEAAR] 243 YP_009725299_NSP3-857-871 YLATALLTLQQIELK WP_010930807.1 BPE 10 80.0 ALLTLQQIEL ALLTLQQLHL BNN[-1.6:-1.3] HLAI[HLA-A*02:01] HLAII[HLA-DRB4*01:01] HU:NP_001316532.1[80.0:AMTTLQQIEL] MB:HMPREF9456_02006[70.0:ALLTLDQVE] HU:NP_620482.3[70.0:ALLGLQHLH] MB:HMPREF1323_0804[90.0:ALKTLQQLHL] 244 YP_009725299_NSP3-1301-1315 LKTLATHGLAAVNSV WP_010931075.1 BPE 10 80.0 TLATHGLAAV TLAGHGLASV BNN[-0.1:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_065761.1[80.0:TLATHELRAV] MB:HMPREF9373_0549[70.0:TLVAHGLAAI] HU:XP_024305455.1[60.0:TVTGHGLA] MB:HMPREF0104_00199[70.0:TMAGHGMADV] 245 YP_009725299_NSP3-1669-1683 SSYIVDSVTVKNGSI WP_010931429.1 BPE 10 80.0 IVDSVTVKNG IVDSVTVFSG BNN[-0.4:0.1] HLAI[NONE] HLAII[NONE] HU:NP_001072.2[70.0:DSVTVRNG] MB:HMPREF1419_00594[80.0:VDSVNVKNG] HU:NP_899199.2[60.0:DSVVIFSG] MB:RUMLAC_02547[80.0:VVDSVSVFSG] 246 YP_009725299_NSP3-1793-1807 TLVATAEAELAKNVS WP_010931112.1 BPE 9 88.9 EAELAKNVS EAELAKEVS BYY[1.2:0.6] HLAI[NONE] HLAII[NONE] HU:XP_011527888.1[66.7:AELSKNLS] MB:HMPREF0534_0716[77.8:EAELAKNI] HU:XP_016856533.1[77.8:EAERAKEV] MB:HMPREF0004_4163[88.9:QAELAKEVS] 247 YP_009725299_NSP3-141-155 PLEFGATSAALQPEE WP_010929926.1 BPE 8 87.5 TSAALQPE TSAALKPE BYY[0.6:0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9282_01472[87.5:TSAALRPE] HU:NP_001073921.1[75.0:TSAASKPK] MB:HMPREF9282_01472[87.5:TSAALRPE] 248 YP_009725299_NSP3-245-259 VYLKHGGGVAGALNK WP_010931319.1 BPE 8 87.5 GGGVAGALN GNGVAGALN BYY[0.6:0.6] HLAI[NONE] HLAII[NONE] HU:NP_003934.1[77.8:GGGLAGAL] MB:CSBG_02680[77.8:GGSIAGALN] HU:NO[NO] MB:HMPREF0988_01048[77.8:GNGLAGAL] 249 YP_009725299_NSP3-317-331 YENFNQHEVLLAPLL WP_019247865.1 BPE 8 87.5 HEVLLAPL HLVLLAPL BNN[-2.0:-1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:BACPEC_00895[87.5:HEVLLVPL] HU:NO[NO] MB:HMPREF0204_13296[87.5:HLVFLAPL] 250 YP_009725299_NSP3-341-355 IHSLRVCVDTVRTNV WP_010931337.1 BPE 8 87.5 CVDTVRTN CVDTVITN BNN[-0.4:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0026_00364[62.5:CIDTIRAN] HU:NP_942146.2[75.0:CVDSVITD] MB:HMPREF1004_03235[87.5:CADTVITN] 251 YP_009725299_NSP3-461-475 LKKDAPYIVGDVVQE WP_010931321.1 BPE 8 87.5 DAPYIVGD DAAYIVGD BNY[-0.2:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1062_01699[75.0:DAPYIIGE] HU:NP_060542.4[62.5:DAAYVIQD] MB:HMPREF1015_01484[87.5:DAAYFVGD] 252 YP_009725299_NSP3-473-487 VQEGVLTAVVIPTKK WP_023853666.1 BPE 8 87.5 QEGVLTAV QEGVLTLV BNN[-0.8:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_060884.1[75.0:QKGVTTAV] MB:POREN0001_1300[100.0:QEGVLTAV] HU:NO[NO] MB:HMPREF0005_01919[100.0:QEGVLTLV] 253 YP_009725299_NSP3-529-543 KKCKSAFYILPSIIS WP_004565905.1 BPE 8 87.5 AFYILPSI AFYNLPSI BNN[-0.5:-1.3] HLAI[NONE] HLAII[NONE] HU:NP_001257304.1[75.0:AFWIIPSI] MB:HMPREF7215_1344[87.5:AFYVLPSI] HU:XP_016879485.1[75.0:AFYNDPSV] MB:HMPREF0005_00679[100.0:AFYNLPSI] 254 YP_009725299_NSP3-653-667 VPATVSVSSPDAVTA WP_003807278.1 BPE 8 87.5 VSVSSPDA VSVSSPAA BYY[1.0:1.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMP0721_1216[87.5:VSVSGPDA] HU:NP_115903.1[75.0:VSVSTPIA] MB:CLOSPO_03635[87.5:LSVSSPAA] 255 YP_009725299_NSP3-681-695 EHFIETISLAGSYKD WP_010929876.1 BPE 8 87.5 TISLAGSY TISLAGGY BNN[-0.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_000138.2[62.5:TVSLGGNY] MB:NO[NO] HU:XP_006724531.1[75.0:TVSLAQGY] MB:HMPREF0005_01117[100.0:TISLAGGY] 256 YP_009725299_NSP3-853-867 DNNCYLATALLTLQQ WP_010930629.1 BPE 8 87.5 LATALLTL LCTALLTL BNN[-1.9:-1.5] HLAI[NONE] HLAII[NONE] HU:XP_005263532.2[62.5:IATAVITL] MB:NO[NO] HU:XP_005259455.1[87.5:LCTALLFL] MB:HMPREF9371_2366[87.5:LCTALLTV] 257 YP_009725299_NSP3-1157-1171 YTPSFKKGAKLLHKP WP_010929835.1 BPE 8 87.5 GAKLLHKP GAKLLHVP BNN[-0.9:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_002908.1[75.0:GARLLHSP] MB:HMPREF0658_0025[87.5:GTKLLHKP] HU:NP_001254542.1[87.5:GAKRLHVP] MB:HMPREF1141_0092[100.0:GAKLLHVP] 258 YP_009725299_NSP3-1313-1327 NSVPWDTIANYAKPF WP_003811322.1 BPE 8 87.5 DTIANYAK ETIANYAK BNN[0.2:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9402_1824[87.5:DTLANYAK] HU:XP_011511727.1[62.5:QSVANYAK] MB:STRINF_00287[87.5:ETIANYTK] 259 YP_009725299_NSP3-1789-1803 EKLKTLVATAEAELA WP_003818932.1 BPE 9 87.5 LVATAEAEL LVAQAEAEL BNN[0.1:0.1] HLAI[HLA-B*07:02, HLA-B*35:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*09:01] HU:NP_003866.1[66.7:LVASGKAEL] MB:NO[NO] HU:XP_016857395.1[66.7:VAQAESEV] MB:HMPREF0297_0103[100.0:LVAQAEAEL] 260 YP_009725304_NSP8-21-35 AYEQAVANGDSEVVL WP_010930151.1 BPE 10 80.0 AYEQAVANGD AYDQAAANGD BYY[1.2:0.8] HLAI[NONE] HLAII[NONE] HU:XP_011527070.1[70.0:AYQYALANGD] MB:HMPREF9457_02304[80.0:YEQAVKNGD] HU:XP_011527070.1[70.0:AYQYALANGD] MB:BACPEC_01262[70.0:YDQAVKNGD] 261 YP_009725304_NSP8-161-175 DADSKIVQLSEISMD WP_003814040.1 BPE 9 88.9 IVQLSEISM IVQLGEISM BNN[-0.7:-0.8] HLAI[HLA-B*07:02, HLA-B*35:01] HLAII[HLA-DRB1*03:01, HLA-DRB1*12:01] HU:NP_757351.2[66.7:IVQLQELSL] MB:HMPREF0005_00301[88.9:VVQLSEISM] HU:NP_997182.1[66.7:IIFIGEISM] MB:HMPREF0127_00511[66.7:VQIGEVSM] 262 YP_009724392.1_ENV-21-35 LAFVVFLLVTLAILT WP_003821340.1 BPE 10 80.0 VVFLLVTLAI LVCLLVTLAI BNN[-2.7:-2.6] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*11:01, HLA-DRB1*13:02, HLA-DRB1*15:01, HLA-DRB4*01:01] HU:XP_011542979.1[70.0:VFLLVTLQV] MB:HMPREF9395_2234[80.0:IVFLLATLAI] HU:XP_016864419.1[60.0:LLCVLILLAI] MB:HMPREF0005_00505[100.0:LVCLLVTLAI] 263 YP_009724392.1_ENV-45-59 NIVNVSLVKPSFYVY WP_010930387.1 BPE 10 80.0 IVNVSLVKPS VVIVSLVKPS BNN[-1.0:-0.5] HLAI[NONE] HLAII[HLA-DRB1*03:01, HLA-DRB1*08:02] HU:NP_004516.2[80.0:IVNSSLVMPS] MB:HMPREF9104_02329[70.0:INTSLVKPS] HU:NP_001310517.1[50.0:IIFYSLIKPS] MB:CATMIT_02476[70.0:VIVSLIKP] 264 YP_009724392.1_ENV-9-23 TGTLIVNSVLLFLAF WP_010929767.1 BPE 8 87.5 SVLLFLAF SVLKFLAF BNN[-2.0:-2.9] HLAI[NONE] HLAII[NONE] HU:XP_024306148.1[75.0:SLLVFLAF] MB:HMPREF9176_2195[87.5:AVLLFLAF] HU:NO[NO] MB:HMPREF9700_00367[100.0:SVLKFLAF] 265 YP_009724390.1_SPIKE-253-267 DSSSGWTAGAAAYYV WP_010931004.1 BPE 11 81.8 SSSGWTAGAAA QSSGWTAGADA BYY[1.3:1.1] HLAI[NONE] HLAII[NONE] HU:XP_006717807.1[54.5:SEGWTTGGA] MB:HMPREF9332_01830[81.8:SSSGWMAGAA] HU:XP_011531020.1[63.6:QSSGRTSGSD] MB:HMPREF0004_2691[81.8:NSSGWTVGADA] 266 YP_009724390.1_SPIKE-257-271 GWTAGAAAYYVGYLQ WP_010930752.1 BPE 10 80.0 AGAAAYYVGY AGAAAHRVGY BYN[0.8:-0.0] HLAI[HLA-A*01:01, HLA-A*03:01, HLA-A*11:01, HLA-B*35:01] HLAII[NONE] HU:NP_060662.2[70.0:SGAAAYYSG] MB:HWAG_01050[80.0:GAAAGYVGY] HU:XP_016877936.1[70.0:AGASPHRVHY] MB:HMPREF0995_05895[80.0:AVTAAHRVGY] 267 YP_009724390.1_SPIKE-509-523 RVVVLSFELLHAPAT WP_010929828.1 BPE 10 80.0 SFELLHAPAT SFELAEAPAT BYN[0.6:-0.4] HLAI[HLA-B*40:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*09:01] HU:XP_011540514.1[60.0:FELLHVPS] MB:HMPREF1123_00716[70.0:FKLLHAPA] HU:XP_016883638.1[60.0:EIAETPAT] MB:HMPREF0005_00501[90.0:SFELVEAPAT] 268 YP_009724390.1_SPIKE-513-527 LSFELLHAPATVCGP WP_010930565.1 BPE 10 80.0 LSFELLHAPA LPFELLHALA BNN[-1.5:-1.0] HLAI[NONE] HLAII[NONE] HU:XP_011542338.1[70.0:LTFPLLHAP] MB:HMPREF9194_02144[70.0:SFELIHVPA] HU:XP_011536387.1[70.0:LPFDLLHA] MB:HMPREF0401_00052[70.0:LPFEVTHAL] 269 YP_009724390.1_SPIKE-617-631 CTEVPVAIHADQLTP WP_010930811.1 BPE 10 80.0 CTEVPVAIHA CTSVPVAIAA BNN[-0.1:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_024301928.1[60.0:CVRCPVAYHA] MB:HMPREF9690_00302[80.0:CTEVPVALAA] HU:NP_036565.2[60.0:CTTVAIAIVA] MB:HMPREF9690_00302[80.0:CTEVPVALAA] 270 YP_009724390.1_SPIKE-249-263 LTPGDSSSGWTAGAA WP_010931004.1 BPE 9 88.9 SSSGWTAGA QSSGWTAGA BYY[1.1:1.1] HLAI[NONE] HLAII[NONE] HU:XP_011508315.1[66.7:ATSVWTAGA] MB:HMPREF9332_01830[88.9:SSSGWMAGA] HU:XP_016878623.1[77.8:SSGWPAGA] MB:HMPREF0378_0798[66.7:QESGWTSG] 271 YP_009724390.1_SPIKE-1-15 MFVFLVLLPLVSSQC WP_003817813.1 BPE 8 87.5 VFLVLLPL VFLRLLPL BNN[-2.4:-2.8] HLAI[NONE] HLAII[NONE] HU:XP_006711325.1[75.0:VHLVLLPI] MB:HMPREF9154_0356[87.5:LFLVLLPL] HU:NO[NO] MB:HMPREF0004_1089[87.5:LFLRLLPL] 272 YP_009724390.1_SPIKE-233-247 INITRFQTLLALHRS WP_010926959.1 BPE 8 87.5 QTLLALHR QTLLATHR BNN[-0.7:-1.5] HLAI[NONE] HLAII[NONE] HU:NP_951058.1[75.0:QLLLAMHR] MB:HMPREF0983_00671[87.5:QQLLALHR] HU:NP_001332818.1[87.5:QLLLATHR] MB:NO[NO] 273 YP_009724390.1_SPIKE-257-271 GWTAGAAAYYVGYLQ WP_010931004.1 BPE 8 87.5 GWTAGAAA GWTAGADA BYY[1.1:0.8] HLAI[NONE] HLAII[NONE] HU:NP_065104.1[75.0:GWGAGASA] MB:HMPREF9412_0397[100.0:GWTAGAAA] HU:XP_016884906.1[62.5:GWVQGADG] MB:HMPREF9163_01970[87.5:GWTTGADA] 274 YP_009724390.1_SPIKE-405-419 DEVRQIAPGQTGKIA WP_010930322.1 BPE 8 87.5 RQIAPGQT RQIAPGKT BYY[1.1:1.1] HLAI[NONE] HLAII[NONE] HU:NP_001316166.1[75.0:RTIAPGKT] MB:FSCG_01463[87.5:RAIAPGQT] HU:NP_001316166.1[87.5:RTIAPGKT] MB:HMPREF1097_01733[87.5:RQMAPGKT] 275 YP_009724390.1_SPIKE-449-463 YNYLYRLFRKSNLKP WP_010930071.1 BPE 8 87.5 RLFRKSNL RLFRKSLL BNN[-1.4:-0.7] HLAI[HLA-B*08:01] HLAII[NONE] HU:NO[NO] MB:HMPREF1526_02530[87.5:RLFRKKNL] HU:NO[NO] MB:HMPREF1048_1945[87.5:KLFRKSLL] 276 YP_009724390.1_SPIKE-509-523 RVVVLSFELLHAPAT WP_003815964.1 BPE 8 87.5 ELLHAPAT ELAHAPAT BYN[0.6:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_011528451.1[75.0:ELLHSPMT] MB:HMPREF9469_02277[75.0:EILHGPAT] HU:NO[NO] MB:HMPREF1135_01587[75.0:QLSHAPAT] 277 YP_009724390.1_SPIKE-701-715 AENSVAYSNNSIAIP WP_010930651.1 BPE 8 100.0 SVAYSNNS SVAYSNNS BYY[0.7:0.7] HLAI[NONE] HLAII[NONE] HU:XP_016885282.1[62.5:AAAYGNNS] MB:NO[NO] HU:XP_016885282.1[62.5:AAAYGNNS] MB:NO[NO] 278 YP_009724390.1_SPIKE-837-851 YGDCLGDIAARDLIC WP_010930080.1 BPE 8 87.5 LGDIAARD LKDIAARD BYN[0.9:0.2] HLAI[NONE] HLAII[NONE] HU:XP_016864718.1[75.0:LGDLAARN] MB:BACCELL_03558[87.5:LGDIAARN] HU:XP_006712316.1[75.0:LKDITAQD] MB:BACCAP_04442[87.5:LKDVAARD] 279 YP_009724390.1_SPIKE-869-883 MIAQYTSALLAGTIT WP_010929741.1 BPE 8 87.5 TSALLAGT TSALMAGT BNN[-0.3:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_001333369.1[75.0:TSAIFAGT] MB:NO[NO] HU:NP_001333369.1[75.0:TSAIFAGT] MB:NO[NO] 280 YP_009724390.1_SPIKE-893-907 ALQIPFAMQMAYRFN WP_010929799.1 BPE 8 87.5 IPFAMQMA IPFTMQMA BNN[-0.7:-0.8] HLAI[NONE] HLAII[NONE] HU:NP_001937.2[62.5:VPFASEMA] MB:HMPREF1030_04624[87.5:IPFTMQMA] HU:NO[NO] MB:HMPREF1030_04624[100.0:IPFTMQMA] 281 YP_009724390.1_SPIKE-989-1003 AEVQIDRLITGRLQS WP_010929759.1 BPE 8 87.5 DRLITGRL DRLIEGRL BNN[-0.5:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1153_0717[87.5:DRIITGRL] HU:NO[NO] MB:HMPREF0874_01440[87.5:DRLVEGRL] 282 YP_009724390.1_SPIKE-1221-1235IAGLIAIVMVTIMLC WP_010931007.1 BPE 8 87.5 IAGLIAIV IAGLVAIV BNN[-1.5:-1.7] HLAI[NONE] HLAII[NONE] HU:NP_207837.2[75.0:IGGLIAVV] MB:NO[NO] HU:NP_207837.2[62.5:IGGLIAVV] MB:HMPREF9455_00969[87.5:VAGLVAIV] 283 YP_009725300_NSP4-329-343 LCLTPVYSFLPGVYS WP_033446227.1 BPE 10 80.0 LCLTPVYSFL LCMTPVLSFL BNN[-1.3:-1.1] HLAI[HLA-A*02:01, HLA-B*35:01] HLAII[HLA-DRB1*07:01] HU:NP_689699.2[70.0:LCQTPGYGFL] MB:HMPREF9171_1374[80.0:LSLTPVWSFL] HU:NP_001161067.1[60.0:CVTPVLTF] MB:HMPREF0542_10403[70.0:CMTPVLSY] 284 YP_009725300_NSP4-145-159 FATSACVLAAECTIF WP_003811709.1 BPE 8 87.5 SACVLAAE SACLLAAE BNN[-1.2:-0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9156_00305[87.5:SACVIAAE] HU:NO[NO] MB:NO[NO] 285 YP_009725300_NSP4-409-423 FSTFEEAALCTFLLN WP_010930466.1 BPE 8 87.5 AALCTFLL AALFTFLL BNN[-2.3:-2.1] HLAI[NONE] HLAII[NONE] HU:NP_000774.2[75.0:SALCTFVL] MB:HMPREF1478_01931[100.0:AALCTFLL] HU:NP_778232.2[75.0:AYIFTFLL] MB:NO[NO] 286 YP_009724397.2_NP-209-223 RMAGNGGDAALALLL WP_010931294.1 BPE 10 80.0 MAGNGGDAAL QAGQGGDAAL BYY[1.4:1.2] HLAI[HLA-B*07:02] HLAII[NONE] HU:NP_001139257.1[70.0:LAGEGGDPAL] MB:HMPREF1057_03430[80.0:MAGNKGDKAL] HU:XP_005244992.1[60.0:KMGKGGDAA] MB:CLOSTHATH_04524[80.0:QYGQGGNAAL] 287 YP_009724397.2_NP-217-231 AALALLLLDRLNQLE WP_010929786.1 BPE 10 80.0 AALALLLLDR ARLALLPLDR BNN[-1.1:-2.2] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[NONE] HU:XP_016871599.1[60.0:VALLLLDQ] MB:HMPREF1026_02610[70.0:LALLLIDR] HU:NP_110385.1[80.0:APLALLPLD] MB:CLS_28730[70.0:RLAFLPLD] 288 YP_009724397.2_NP-241-255 QQGQTVTKKSAAEAS WP_010931007.1 BPE 10 80.0 GQTVTKKSAA GQTVTEKSLA BYY[1.5:0.9] HLAI[NONE] HLAII[NONE] HU:NP_001035545.1[60.0:QTMTKKAA] MB:FUAG_01453[70.0:GKTVTKKS] HU:NP_001356276.1[70.0:GQTFDEKTLA] MB:HMPREF9695_04261[80.0:GQTVTEKNL] 289 YP_009724397.2_NP-81-95 DDQIGYYRRATRRIR WP_010926777.1 BPE 8 87.5 RRATRRIR RYATRRIR BNN[-0.2:0.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0058_1763[87.5:RRATRKIR] HU:XP_016883299.1[62.5:RWAVRRLR] MB:HMPREF0496_1935[87.5:RYATERIR] 290 YP_009724397.2_NP-209-223 RMAGNGGDAALALLL WP_010930666.1 BPE 8 87.5 GGDAALAL GGTAALAL BNN[-0.1:0.2] HLAI[NONE] HLAII[NONE] HU:XP_024302318.1[75.0:AGDGALAL] MB:HMPREF1084_02767[87.5:GGDGALAL] HU:NP_001292171.1[75.0:GGSAVLAL] MB:HMPREF0693_0671[87.5:GGSAALAL] 291 YP_009724397.2_NP-237-251 KGQQQQGQTVTKKSA WP_010931007.1 BPE 8 87.5 GQTVTKKS GQTVTEKS BYY[1.1:0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9469_02146[87.5:GQTYTKKS] HU:XP_016879960.1[62.5:GQAVTERA] MB:HMPREF9695_04261[87.5:GQTVTEKN] 292 YP_009724397.2_NP-285-299 NFGDQELIRQGTDYK WP_003808629.1 BPE 8 87.5 GDQELIRQ GDQELARQ BYN[0.7:0.1] HLAI[NONE] HLAII[NONE] HU:XP_024304698.1[62.5:GDKQLIRE] MB:HMPREF1056_01141[87.5:GDQEFIRQ] HU:NP_115268.2[75.0:GDREAARQ] MB:HMPREF1526_02384[75.0:GDDELSRQ] 293 YP_009725305_NSP9-33-47 NTTKGGRFVLALLSD WP_010931570.1 BPE 10 80.0 GGRFVLALLS GGRDVLAPLS BNN[0.2:-1.6] HLAI[NONE] HLAII[NONE] HU:XP_011510519.1[70.0:GGRIVLAL] MB:HMP0721_1596[80.0:GGRFVISLLS] HU:XP_024308095.1[70.0:GGRDMLEPL] MB:HMPREF0004_0612[90.0:GGRDVLQPLS] 294 YP_009725305_NSP9-37-51 GGRFVLALLSDLQDL WP_003813570.1 BPE 8 87.5 VLALLSDL VLALLSIL BNN[-2.5:-1.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001166289.1[87.5:VLAWLSIL] MB:NO[NO] 295 YP_009725305_NSP9-81-95 KGPKVKYLYFIKGLN WP_003820744.1 BPE 8 87.5 YLYFIKGL YLAFIKGL BNN[-1.7:-1.9] HLAI[HLA-A*02:01, HLA-B*08:01] HLAII[NONE] HU:NP_775487.2[75.0:YLYFLKHL] MB:NO[NO] HU:NO[NO] MB:CLOLEP_00736[87.5:HLAFIKGL] 296 YP_009725305_NSP9-101-113 MVLGSLAATVRLQ WP_010930464.1 BPE 8 87.5 LAATVRLQ LAATVRQQ BNN[-0.0:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF1324_1570[87.5:LAATIRQQ] 297 YP_009725309_35EXON-361-375 YKIEELFYSYATHSD WP_010930895.1 BPE 10 80.0 EELFYSYATH EEDFNSYATH BYN[0.7:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_008835.5[60.0:EEVFRPYAKH] MB:HMPREF1238_1385[90.0:EELFRSYATH] HU:NP_077010.1[70.0:EESFNLQATH] MB:HMPREF9702_03050[100.0:EEDFNSYATH] 298 YP_009725309_35EXON-69-83 YPNMFITREEAIRHV WP_003815190.1 BPE 8 87.5 ITREEAIR ISREEAIR BYY[1.2:1.0] HLAI[NONE] HLAII[NONE] HU:NP_758962.1[62.5:LSREEALR] MB:HMPREF9441_01864[100.0:ITREEAIR] HU:NP_758962.1[75.0:LSREEALR] MB:BACPLE_00452[100.0:ISREEAIR] 299 YP_009725309_35EXON-97-111 TREAVGTNLPLQLGF WP_010930353.1 BPE 8 87.5 GTNLPLQL GTNLTLQL BNN[-0.6:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_001034463.4[75.0:GKNLPLRL] MB:HMPREF9454_01926[87.5:GTNLPLQV] HU:NP_061724.1[75.0:GSNLTLQV] MB:HMPREF0005_03738[100.0:GTNLTLQL] 300 YP_009725309_35EXON-469-483 KSATCITRCNLGGAV WP_010930887.1 BPE 8 87.5 RCNLGGAV RCVLGGAV BNN[-0.7:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_011527121.1[62.5:RCDIGGAL] MB:CLOL250_00799[75.0:RCNLAGAI] HU:NO[NO] MB:NO[NO] 301 YP_009725310_RNASE-177-191 NYYKKVDGVVQQLPE WP_010929997.1 BPE 8 100.0 VDGVVQQL VDGVVQQL BNN[-0.2:-0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:FSBG_01189[75.0:IDGVVQRL] HU:NO[NO] MB:FSBG_01189[75.0:IDGVVQRL] 302 YP_009725310_RNASE-301-315 DFVEIIKSQDLSVVS WP_010931260.1 BPE 8 87.5 SQDLSVVS SQDLSVVA BNN[-0.2:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:CLOLEP_01339[87.5:SQDLSVLA] 303 YP_009724391.1_ORF3a-101-115 LEAPFLYLYALVYFL WP_035125344 CTE 10 80.0 LEAPFLYLYA LSAPFLYLSA BNN[-1.0:-1.2] HLAI[NONE] HLAII[NONE] HU:XP_006715579.1[50.0:LNIPFMYLFS] MB:HMPREF9006_1880[70.0:LEGPFLYL] HU:XP_024310050.1[70.0:LCAPFLYLN] MB:CCU_17290[80.0:LSAPFVYLS] 304 YP_009725307_POL-141-155 TLKEILVTYNCCDDD WP_011100403 CTE 8 87.5 KEILVTYN KEILNTYN BNN[-0.4:-1.0] HLAI[NONE] HLAII[NONE] HU:XP_006724642.1[75.0:KKILVTYS] MB:HMPREF0204_15280[100.0:KEILVTYN] HU:NO[NO] MB:HMPREF9136_2599[100.0:KEILNTYN] 305 YP_009725307_POL-357-371 QDVNLHSSRLSFKEL WP_011099228 CTE 8 87.5 SRLSFKEL SQLSFKEL BNN[-0.6:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9308_00746[87.5:SRVSFKEL] HU:NO[NO] MB:BSIG_5926[87.5:SQLSYKEL] 306 YP_009725307_POL-365-379 RLSFKELLVYAADPA WP_011099228 CTE 8 87.5 RLSFKELL QLSFKELL BNN[-1.1:-1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 307 YP_009725307_POL-493-507 VIVNNLDKSAGFPFN WP_011100662 CTE 8 87.5 VIVNNLDK VILNNLDK BNN[-0.8:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_005248441.1[75.0:VVVENLDK] MB:HMP0721_0777[75.0:IVVNNLDK] HU:NP_001127911.1[75.0:VILNNLEE] MB:DORFOR_01260[87.5:VILNNLDE] 308 YP_009725307_POL-537-551 PTITQMNLKYAISAK WP_035109175 CTE 8 87.5 NLKYAISA NLKFAISA BNN[-1.0:-0.6] HLAI[NONE] HLAII[NONE] HU:XP_016885381.1[87.5:NLKKAISA] MB:HMPREF1486_01382[100.0:NLKYAISA] HU:XP_016885381.1[87.5:NLKKAISA] MB:HMPREF9695_00317[100.0:NLKFAISA] 309 YP_009725307_POL-541-555 QMNLKYAISAKNRAR WP_011098808 CTE 8 87.5 AISAKNRA ALSAKNRA BYY[0.4:0.4] HLAI[NONE] HLAII[NONE] HU:NP_001165415.1[75.0:AVSLKNRA] MB:HMPREF9071_0876[87.5:AISAKNRG] HU:NP_001350420.1[75.0:ALSSSNRA] MB:CAPGI0001_2546[87.5:ALSAKNRG] 310 YP_009725303_NSP7-5-19 DVKCTSVVLLSVLQQ WP_011098951 CTE 8 87.5 TSVVLLSV TSVVLLAV BNN[-1.8:-1.7] HLAI[NONE] HLAII[NONE] HU:NP_009086.4[87.5:TSVVLLGV] MB:NO[NO] HU:NP_001353153.1[87.5:TSVSLLAV] MB:NO[NO] 311 YP_009724394.1_ORF6-29-43 LDYIINLIIKNLSKS WP_011100485 CTE 8 87.5 NLIIKNLS NQIIKNLS BNN[-0.7:-1.3] HLAI[NONE] HLAII[NONE] HU:NP_689957.3[62.5:NLVISNIS] MB:NO[NO] HU:NP_056442.2[62.5:NQLIENVS] MB:HMPREF9475_03565[75.0:NQLVKNLS] 312 YP_009725301_3CPR-277-291 NGRTILGSALLEDEF WP_011099273 CTE 8 87.5 RTILGSAL RTILGSFL BNN[-1.2:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1206_01879[87.5:RTILGSAM] HU:NO[NO] MB:HMPREF0061_1552[100.0:RTILGSFL] 313 YP_009725311_2ORMT-133-147 DPKTKNVTKENDSKE WP_011099164 CTE 8 87.5 VTKENDSK VTKENDVK BYY[1.0:1.5] HLAI[NONE] HLAII[NONE] HU:NP_001017930.1[75.0:VTRENDKK] MB:NO[NO] HU:NP_057330.2[75.0:VTQEDDVK] MB:HMPREF9136_1172[100.0:VTKENDVK] 314 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_011098575 CTE 11 90.9 LQGPPGTGKSH VQGPPGTGKSH BYY[2.2:2.1] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[NONE] HU:XP_011512465.1[72.7:LHGPPGTGKT] MB:HMPREF9402_1702[90.9:VQGPPGTGKSH] HU:XP_011516709.1[72.7:IHGPPGTGKS] MB:HMPREF9402_1702[100.0:VQGPPGTGKSH] 315 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_035124884 CTE 10 80.0 LQGPPGTGKS LYGPPGTGKT BYY[2.0:2.2] HLAI[HLA-A*03:01] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:NP_000457.1[100.0:LYGPPGTGKT] MB:HMPREF0380_01389[100.0:LYGPPGTGKT] 316 YP_009725308_HEL-281-295 QGPPGTGKSHFAIGL WP_011098575 CTE 10 100.0 QGPPGTGKSH QGPPGTGKSH BYY[2.4:2.4] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[80.0:HGPPGTGKS] MB:HMPREF9402_1702[100.0:QGPPGTGKSH] HU:XP_011516709.1[80.0:HGPPGTGKS] MB:HMPREF9402_1702[100.0:QGPPGTGKSH] 317 YP_009725308_HEL-133-147 FAAETLKATEETFKL WP_011098478 CTE 9 88.9 KATEETFKL KATEETVKL BYY[0.7:0.5] HLAI[HLA-B*35:01] HLAII[NONE] HU:NP_001091952.1[55.6:ATEDTFRM] MB:HMPREF9945_00787[88.9:KATEETVKL] HU:NP_057662.3[77.8:KSTEETEKL] MB:HMPREF1526_02491[100.0:KATEETVKL] 318 YP_009725308_HEL-561-575 FNVAITRAKVGILCI WP_011098575 CTE 9 88.9 FNVAITRAK FNVAATRAK BNN[0.1:-0.5] HLAI[NONE] HLAII[HLA-DRB1*04:01, HLA-DRB1*08:02, HLA-DRB1*11:01, HLA-DRB5*01:01] HU:NP_066014.1[88.9:FNVAVTRAK] MB:HMPREF9237_00105[88.9:FNVAITRAR] HU:NP_066014.1[88.9:FNVAVTRAK] MB:HMPREF9402_1702[88.9:FNVAASRAK] 319 YP_009725308_HEL-177-191 NRNYVFTGYRVTKNS WP_011099998 CTE 8 87.5 VFTGYRVT VFRGYRVT BNN[-0.5:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF1207_04068[87.5:IFRGYRVT] 320 YP_009725308_HEL-273-287 GMQKYSTLQGPPGTG WP_011098575 CTE 8 87.5 LQGPPGTG VQGPPGTG BYY[2.5:2.3] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF1068_02855[100.0:LQGPPGTG] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF9464_00698[100.0:VQGPPGTG] 321 YP_009725308_HEL-273-287 GMQKYSTLQGPPGTG WP_035124884 CTE 8 87.5 LQGPPGTG LYGPPGTG BYY[2.0:2.3] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF1068_02855[100.0:LQGPPGTG] HU:NP_000457.1[100.0:LYGPPGTG] MB:HMPREF1323_1465[100.0:LYGPPGTG] 322 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_011099293 CTE 8 87.5 GPPGTGKS GPPGTGKT BYY[2.6:2.6] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] HU:NP_066363.1[100.0:GPPGTGKT] MB:COLSTE_00461[100.0:GPPGTGKT] 323 YP_009725308_HEL-293-307 IGLALYYPSARIVYT WP_011099956 CTE 8 87.5 YYPSARIV YYKSARIV BNN[-0.3:0.2] HLAI[NONE] HLAII[NONE] HU:NP_115536.2[87.5:YYPSARPV] MB:STAHO0001_1891[87.5:YYPEARIV] HU:XP_016865213.1[75.0:YFKSARNV] MB:HMPREF0216_00223[100.0:YYKSARIV] 324 YP_009725308_HEL-321-335 ALKYLPIDKCSRIIP WP_035110393 CTE 8 87.5 IDKCSRII IDKVSRII BNN[-0.6:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0444_1439[87.5:IDKCNRII] HU:NP_000799.1[75.0:VDKISRII] MB:HMPREF9719_01289[87.5:IDKVSRVI] 325 YP_009725308_HEL-537-551 QGSEYDYVIFTQTTE WP_035109029 CTE 8 87.5 GSEYDYVI GSEIDYVI BNN[-0.1:0.3] HLAI[NONE] HLAII[NONE] HU:NP_000255.2[50.0:GSEFDFIV] MB:DESPIG_01822[87.5:GSEYDYII] HU:NO[NO] MB:HMPREF9400_1000[87.5:GHEIDYVI] 326 YP_009725297_LP-85-99 MVELVAELEGIQYGR WP_011100400 CTE 10 80.0 LVAELEGIQY LVAILEGIRY BNN[-1.3:-0.5] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[NONE] HU:NP_076962.2[60.0:ADVEGIQY] MB:HMPREF9469_04931[80.0:AELEGIQY] HU:XP_016880468.1[60.0:AVLEGARY] MB:HMPREF0783_2477[80.0:LVSILEGIR] 327 YP_009725297_LP-145-159 LGDELGTDPYEDFQE WP_011100215 CTE 8 87.5 GTDPYEDF GRDPYEDF BYY[1.5:1.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:ROI_04820[75.0:GNDPYEDY] HU:NO[NO] MB:HMPREF9104_00379[100.0:GRDPYEDF] 328 YP_009724395.1_ORF7a-1-15 MKIILFLALITLATC WP_011100002 CTE 12 91.7 IILFLALITLAT IILFLALITLIT BNN[-2.8:-2.5] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*11:01, HLA-DRB1*15:01, HLA-DRB4*01:01, HLA-DRB5*01:01] HU:NP_000854.1[66.7:LVMLLALITLAT] MB:HMPREF1020_04908[75.0:LILFLALITAA] HU:NP_775107.1[66.7:IITFLSEITLI] MB:HMPREF1069_02120[66.7:IMLFIAFITLI] 329 YP_009724395.1_ORF7a-25-39 RGTTVLLKEPCSSGT WP_011099283 CTE 11 81.8 VLLKEPCSSGT VLLKEPFSKGT BNN[0.1:0.3] HLAI[NONE] HLAII[NONE] HU:XP_011530322.1[72.7:VLLDEPAYSGT] MB:HMPREF9233_00298[63.6:VLMKRPCSS] HU:NP_003089.1[54.5:VLLRQPFEK] MB:HMPREF0322_00062[81.8:VLLKEPLTKGT] 330 YP_009724395.1_ORF7a-5-19 LFLALITLATCELYH WP_011100002 CTE 10 90.0 LFLALITLAT LFLALITLIT BNN[-2.6:-2.2] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*07:01, HLA-DRB1*08:02, HLA-DRB1*11:01, HLA-DRB4*01:01] HU:NP_000854.1[80.0:MLLALITLAT] MB:ES1_22190[80.0:LFLAVITLA] HU:XP_024307253.1[70.0:LFLALAVLVT] MB:HMPREF0021_02790[80.0:LFLALITL] 331 YP_009724395.1_ORF7a-101-115 FLIVAAIVFITLCFT WP_011099871 CTE 8 87.5 AAIVFITL AAILFITL BNN[-2.5:-2.1] HLAI[HLA-B*08:01] HLAII[NONE] HU:XP_016861551.1[62.5:AVVVFVTL] MB:HMPREF0766_10686[100.0:AAIVFITL] HU:NO[NO] MB:HMPREF1084_02986[100.0:AAILFITL] 332 YP_009725318.1_ORF7b-25-39 LIIFWFSLELQDHNE WP_035124806 CTE 8 87.5 FSLELQDH FYLELQDH BNN[-0.9:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_004516.2[87.5:FSLELSDH] MB:HMPREF0880_04673[75.0:FDMELQDH] HU:XP_011508426.1[75.0:YILELQDH] MB:HMPREF9451_01298[100.0:FYLELQDH] 333 YP_009725298_NSP2-345-359 EQKSILSPLYAFASE WP_035124382 CTE 10 80.0 ILSPLYAFAS ILSPNYANAS BYN[0.6:-0.8] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*09:01] HU:NP_001186578.1[60.0:ILSPVYRF] MB:HMPREF1248_0970[70.0:VISPLYAFA] HU:XP_016860662.1[70.0:ILSPNYVNG] MB:RO1_01100[70.0:VLTPNYANA] 334 YP_009725298_NSP2-453-467 EKFKEGVEFLRDGWE WP_011100706 CTE 10 80.0 KEGVEFLRDG KEGVEFQLDG BYN[0.5:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_055524.3[70.0:REGQEFLRD] MB:HMPREF1013_02398[80.0:KEGVLFLRD] HU:NP_060019.2[60.0:KDGVMFQID] MB:HMPREF9294_0472[80.0:KEGVEFQL] 335 YP_009725298_NSP2-593-607 AVEAPLVGTPVCING WP_011100465 CTE 10 80.0 LVGTPVCING LVGTIVGING BNN[-0.6:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_006536.3[60.0:LIGCPVCI] MB:PNI0446_00136[80.0:VGTPYCING] HU:XP_011511221.1[70.0:LRGTIIGIKG] MB:HMPREF0971_01469[80.0:LAGTIVGISG] 336 YP_009725298_NSP2-69-83 YELQTPFEIKLAKKF WP_035125273 CTE 8 87.5 EIKLAKKF EIKKAKKF BYN[0.5:-0.7] HLAI[HLA-B*08:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:NP_694942.3[62.5:DIKLPRKF] MB:HMPREF0183_0089[75.0:EIRMAKKF] HU:NP_001335644.1[62.5:EVKKLKRF] MB:HMPREF9007_01711[87.5:EIKKAKKY] 337 YP_009725298_NSP2-437-451 FGTVYEKLKPVLDWL WP_011099872 CTE 8 87.5 GTVYEKLK GTVYNKLK BNN[-0.1:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_001030086.1[87.5:GTVHEKLK] MB:SUBVAR_07183[87.5:GTVYEHLK] HU:NP_001154816.1[87.5:GTVINKLK] MB:HMPREF9695_03101[87.5:GTVYNDLK] 338 YP_009724393.1_MP-133-147 LLESELVIGAVILRG WP_035125104 CTE 9 88.9 ELVIGAVIL ELVIGDVIL BNN[-1.2:-1.6] HLAI[NONE] HLAII[HLA-DRB1*03:01] HU:NP_612387.1[55.6:DLIIGSVI] MB:NO[NO] HU:NP_005438.2[55.6:ETTVGDVVL] MB:CK5_07540[100.0:ELVIGDVIL] 339 YP_009724393.1_MP-5-19 NGTITVEELKKLLEQ WP_011099907 CTE 8 87.5 VEELKKLL VEELKKEL BNN[-0.1:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9489_1246[87.5:VEELKKLI] HU:XP_011521771.1[100.0:VEELKKEL] MB:HMPREF0663_11368[100.0:VEELKKEL] 340 YP_009724393.1_MP-157-171 GRCDIKDLPKEITVA WP_011099043 CTE 8 87.5 IKDLPKEI IKDNPKEI BYY[1.3:1.6] HLAI[NONE] HLAII[NONE] HU:NP_001138424.1[75.0:IKDIPKEV] MB:HMPREF1062_06327[75.0:VKDLPKEL] HU:NO[NO] MB:HMPREF9006_1548[87.5:IKDHPKEI] 341 YP_009725299_NSP3-421-435 VTTTLEETKFLTENL WP_011099591 CTE 10 80.0 EETKFLTENL EETKALIENL BNN[-0.2:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_443117.3[60.0:ETKFKTEDI] MB:HMPREF9448_02222[80.0:EKEKFLTENL] HU:NP_001295.2[80.0:ETKAIIENL] MB:HMPREF9383_0045[90.0:EETKAHIENL] 342 YP_009725299_NSP3-529-543 KKCKSAFYILPSIIS WP_035110747 CTE 10 80.0 SAFYILPSII SAFYILSSVI BNN[-1.5:-1.3] HLAI[HLA-A*02:01, HLA-A*23:01, HLA-A*24:02] HLAII[HLA-DRB1*07:01] HU:NP_066565.1[60.0:SFYTLPSTI] MB:HMPREF0381_0922[80.0:SSFYILPSI] HU:NP_001156910.1[70.0:FYILASVI] MB:CLOSPO_01289[90.0:SAFYILASVI] 343 YP_009725299_NSP3-697-711 SYSGQSTQLGIEFLK WP_035124920 CTE 9 88.9 QSTQLGIEF QSTQSGIEF BYN[0.8:-0.1] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[NONE] HU:NP_004637.1[55.6:STQLAVQF] MB:HMPREF1204_03444[77.8:QSTQLGID] HU:NO[NO] MB:LAF_0755[77.8:QSTQAGIEL] 344 YP_009725299_NSP3-13-27 IEVQGYKSVNITFEL WP_011099856 CTE 8 87.5 GYKSVNIT GYKSVIIT BNN[-0.7:0.3] HLAI[NONE] HLAII[NONE] HU:NP_055447.1[62.5:GYQHVNVT] MB:HMPREF0380_00673[87.5:GYKSVNVT] HU:XP_016873362.1[75.0:GFKPVIIT] MB:HMPREF1040_0738[75.0:GYKSVVVT] 345 YP_009725299_NSP3-29-43 ERIDKVLNEKCSAYT WP_011098778 CTE 8 87.5 IDKVLNEK IDEVLNEK BNN[-0.1:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_001306146.1[87.5:IDKVLSEK] MB:HMPREF9064_0970[75.0:VDKILNEK] HU:NP_001306146.1[75.0:IDKVLSEK] MB:ANACAC_03757[100.0:IDEVLNEK] 346 YP_009725299_NSP3-213-227 YLKLTDNVYIKNADI WP_035125101 CTE 8 87.5 TDNVYIKN TDNVPIKN BYN[0.8:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001291477.1[75.0:TQNIPIKN] MB:HMPREF9716_00636[100.0:TDNVPIKN] 347 YP_009725299_NSP3-301-315 GPNVNKGEDIQLLKS WP_035109352 CTE 8 87.5 NKGEDIQL NKGEDIIL BNY[0.2:0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9446_02486[87.5:NKGEDIPL] HU:NO[NO] MB:HMPREF9019_1114[87.5:NRGEDIIL] 348 YP_009725299_NSP3-381-395 VEQKIAEIPKEEVKP WP_011099920 CTE 8 87.5 EIPKEEVK EIPKEEEK BYY[1.6:1.1] HLAI[NONE] HLAII[NONE] HU:XP_011509098.1[62.5:QLPKEEIK] MB:HMPREF9455_02237[75.0:KVPKEEVK] HU:XP_016876035.1[75.0:KIPKQEEK] MB:HMPREF1135_01714[100.0:EIPKEEEK] 349 YP_009725299_NSP3-425-439 LEETKFLTENLLLYI WP_011100577 CTE 8 87.5 LTENLLLY LTEKLLLY BNN[-1.6:-1.5] HLAI[HLA-A*01:01] HLAII[NONE] HU:NP_001561.3[75.0:LMENILLY] MB:HMPREF0551_2222[87.5:LTEKLLLY] HU:NO[NO] MB:HMPREF0551_2222[100.0:LTEKLLLY] 350 YP_009725299_NSP3-605-619 YFYTSKTTVASLINT WP_035125029 CTE 8 87.5 KTTVASLI KTTVASTI BNN[0.3:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_001269220.1[87.5:KTTVASLL] MB:HMPREF0305_10303[87.5:KTTIASLI] HU:NO[NO] MB:NO[NO] 351 YP_009725299_NSP3-681-695 EHFIETISLAGSYKD WP_011099660 CTE 8 87.5 SLAGSYKD SLAGEYKD BYY[0.7:0.6] HLAI[NONE] HLAII[NONE] HU:XP_024304445.1[75.0:SLSGSYLD] MB:NO[NO] HU:NP_075391.3[75.0:SLAEEYED] MB:HMPREF0993_02558[87.5:SLAGQYKD] 352 YP_009725299_NSP3-701-715 QSTQLGIEFLKRGDK WP_011100609 CTE 8 87.5 EFLKRGDK EFLKRGIK BNN[-0.6:0.2] HLAI[NONE] HLAII[NONE] HU:XP_016863848.1[75.0:EFLPRGDR] MB:CLOHIR_00459[87.5:EFLKRADK] HU:NO[NO] MB:HMPREF1092_01582[100.0:EFLKRGIK] 353 YP_009725299_NSP3-777-791 GPTYLDGADVTKIKP WP_011099929 CTE 8 87.5 GADVTKIK GQDVTKIK BYY[0.5:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:ROSINTL182_05969[87.5:GADLTKIK] HU:NP_002508.2[62.5:GQDATRIR] MB:HMPREF1348_01538[100.0:GQDVTKIK] 354 YP_009725299_NSP3-1125-1139 QLTGYKKPASRELKV WP_011099659 CTE 8 87.5 KKPASREL KKPASRIL BYY[0.5:1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:RUMLAC_01044[75.0:RKPSSREL] HU:NP_000275.1[75.0:QKPASRVL] MB:HMPREF9449_01972[87.5:KKPASRII] 355 YP_009725299_NSP3-1289-1303 IKKPNELSRVLGLKT WP_035111301 CTE 8 87.5 NELSRVLG NELNRVLG BNN[-0.5:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_001013764.1[75.0:NDLARVLG] MB:HMPREF1012_03626[87.5:NEFSRVLG] HU:NP_001363156.1[62.5:DEINRLLG] MB:HMPREF0666_00345[100.0:NELNRVLG] 356 YP_009725299_NSP3-1377-1391 PTTIAKNTVKSVGKF WP_011100305 CTE 8 87.5 KNTVKSVG KNTVKSRG BYY[0.8:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1098_00097[87.5:KNTVKSTG] HU:NO[NO] MB:HMPREF1098_00097[87.5:KNTVKSTG] 357 YP_009725299_NSP3-1401-1415 KSPNFSKLINIIIWF WP_035124818 CTE 8 87.5 SKLINIII SKLENIII BNN[-1.0:-1.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_005561.1[62.5:AKVENMII] MB:NO[NO] 358 YP_009725299_NSP3-1493-1507 ISSFKWDLTAFGLVA WP_011099343 CTE 8 87.5 LTAFGLVA LTAFGLQA BNN[-0.7:-1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9958_0925[87.5:LSAFGLVA] HU:NP_001062.1[62.5:LSVFGMQA] MB:EUBDOL_01214[100.0:LTAFGLQA] 359 YP_009725299_NSP3-1597-1611 RNRATRVECTTIVNG WP_011100542 CTE 8 87.5 ECTTIVNG ETTTIVNG BYN[0.9:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_005272095.1[75.0:ECSTLVNG] MB:HMPREF1061_01922[75.0:KCTTIING] HU:NO[NO] MB:HMPREF9412_5764[87.5:ELTTIVNG] 360 YP_009725299_NSP3-1797-1811 TAEAELAKNVSLDNV WP_011100374 CTE 8 100.0 ELAKNVSL ELAKNVSL BNN[-0.3:-0.3] HLAI[HLA-B*08:01, HLA-B*40:01] HLAII[NONE] HU:XP_011536322.1[75.0:ELARNVAL] MB:NO[NO] HU:XP_011536322.1[75.0:ELARNVAL] MB:NO[NO] 361 YP_009725299_NSP3-1881-1895 INAQVAKSHNIALIW WP_011099261 CTE 8 87.5 VAKSHNIA VAESHNIA BNN[0.3:0.1] HLAI[NONE] HLAII[NONE] HU:XP_011517562.1[50.0:IYRSHNVA] MB:HMPREF0648_1982[87.5:VAKRHNIA] HU:NO[NO] MB:FUAG_01617[75.0:IADSHNIA] 362 YP_009724392.1_ENV-1-15 MYSFVSEETGTLIVN WP_035111765 CTE 8 87.5 VSEETGTL VSEETGTI BYY[1.1:1.1] HLAI[NONE] HLAII[NONE] HU:NP_001354804.1[87.5:VSEETGCL] MB:HMPREF9199_0189[87.5:VSEETGTI] HU:NP_001354804.1[75.0:VSEETGCL] MB:MITSMUL_03479[100.0:VSEETGTI] 363 YP_009724392.1_ENV-1-15 MYSFVSEETGTLIVN WP_035109627 CTE 8 87.5 SFVSEETG SFVSEETA BYY[0.6:0.7] HLAI[NONE] HLAII[NONE] HU:NP_659412.3[75.0:SFLSEELG] MB:HMPREF0860_2206[87.5:SFVKEETG] HU:NO[NO] MB:NO[NO] 364 YP_009724392.1_ENV-45-59 NIVNVSLVKPSFYVY WP_011099949 CTE 8 87.5 VKPSFYVY VKPSSYVY BYN[0.6:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0072_1683[75.0:VRPAFYVY] HU:XP_016874256.1[62.5:LRPSDYVY] MB:HMPREF0078_0039[100.0:VKPSSYVY] 365 YP_009724390.1_SPIKE-1061-1075VFLHVTYVPAQEKNF WP_011100834 CTE 10 80.0 TYVPAQEKNF TNVHAQEKNF BYY[1.1:0.8] HLAI[HLA-B*35:01] HLAII[NONE] HU:NP_001155057.1[60.0:YAPANEKN] MB:HMPREF9732_01105[80.0:TYVPAQDKN] HU:XP_011517372.1[60.0:THVHSQERSF] MB:HMPREF9446_00797[70.0:VHAQEKDF] 366 YP_009724390.1_SPIKE-1141-1155LQPELDSFKEELDKY WP_011098999 CTE 10 80.0 LDSFKEELDK LKSIKEELDK BNN[0.1:0.3] HLAI[NONE] HLAII[NONE] HU:NP_004239.2[70.0:DSFREELRK] MB:HMPREF9694_03292[80.0:LDSFEERLDK] HU:NP_001188386.1[80.0:LKSMEEELDK] MB:HMPREF9019_1918[70.0:KAVKEELDK] 367 YP_009724390.1_SPIKE-473-487 YQAGSTPCNGVEGFN WP_011099622 CTE 8 87.5 PCNGVEGF PTNGVEGF BYY[1.0:0.6] HLAI[NONE] HLAII[NONE] HU:NP_001269353.1[62.5:PCGGQKGF] MB:HMPREF1082_04156[75.0:PCSGVEGY] HU:NP_001244.1[62.5:PSNGAEGL] MB:HMPREF9310_01455[87.5:PTNGVQGF] 368 YP_009724390.1_SPIKE-817-831 FIEDLLFNKVTLADA WP_035125039 CTE 8 87.5 IEDLLFNK IEDLLKNK BNN[-0.5:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_001155088.2[62.5:VQDLSFNK] MB:NO[NO] HU:NP_067010.3[75.0:IDDFLKNK] MB:HMPREF9141_1525[87.5:IEDLMKNK] 369 YP_009724390.1_SPIKE-1145-1159LDSFKEELDKYFKNH WP_011098637 CTE 8 87.5 EELDKYFK EKLDKYFK BNN[-0.2:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_060557.3[75.0:EAVDKYFK] MB:HMPREF9622_01278[87.5:EELDKYIK] HU:XP_024309095.1[87.5:EILDKYFK] MB:HMPREF9336_02596[87.5:EKLPKYFK] 370 YP_009724390.1_SPIKE-1257-1271DEDDSEPVLKGVKLH WP_035109529 CTE 8 87.5 EPVLKGVK EEVLKGVK BNN[-0.2:0.1] HLAI[NONE] HLAII[NONE] HU:XP_024307942.1[75.0:EPVLRGLK] MB:NO[NO] HU:NO[NO] MB:HMPREF1323_0764[87.5:EEVLRGVK] 371 YP_009725300_NSP4-353-367 LTNDVSFLAHIQWMV WP_035125016 CTE 8 87.5 NDVSFLAH NDVSTLAH BNN[0.1:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_011517438.1[75.0:NQVTFLAH] MB:ALIPUT_00112[75.0:NDVDFIAH] HU:NP_001278253.1[62.5:NDVQTISH] MB:HMPREF1092_01548[100.0:NDVSTLAH] 372 YP_009724397.2_NP-145-159 HIGTRNPANNAAIVL WP_011098740 CTE 8 87.5 ANNAAIVL ANNAVIVL BNN[-1.0:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_061955.1[75.0:ANNPGIVL] MB:NO[NO] HU:NO[NO] MB:COLSTE_00368[75.0:ANNAIVVL] 373 YP_009725305_NSP9-41-55 VLALLSDLQDLKWAR WP_011098810 CTE 8 87.5 LSDLQDLK LSDLSDLK BNN[-0.1:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_016856964.1[87.5:LSDLEDLK] MB:HMPREF9516_02647[87.5:LKDLQDLK] HU:XP_016856964.1[87.5:LSDLEDLK] MB:NO[NO] 374 YP_009725309_35EXON-41-55 DIPGIPKDMTYRRLI WP_011099429 CTE 10 80.0 PKDMTYRRLI PKDMTIRKLI BNN[-0.5:-0.2] HLAI[HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:NP_002218.2[60.0:PKDISYKRYI] MB:CLOSPO_03683[70.0:PKDMTIRRIV] HU:NO[NO] MB:CLOSPO_03683[70.0:PKDMTIRRIV] 375 YP_009725309_35EXON-285-299 CFVKRVDWTIEYPII WP_035110925 CTE 10 80.0 VKRVDWTIEY LKRVDWDIEY BNN[-0.2:-0.3] HLAI[HLA-B*35:01, HLA-B*44:02, HLA-B*44:03] HLAII[HLA-DRB3*01:01] HU:NP_001307170.1[60.0:VRRFDWGAEY] MB:CLOSPO_00846[80.0:LKRVDWNIEY] HU:NP_001120650.1[70.0:LKRGDWDI] MB:CLOSPO_00846[90.0:LKRVDWNIEY] 376 YP_009725309_35EXON-37-51 GLCVDIPGIPKDMTY WP_011100544 CTE 8 87.5 IPGIPKDM IPGIPKDV BYY[1.0:0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:ANACOL_04216[87.5:IPGTPKDM] HU:NO[NO] MB:HMPREF0378_0577[87.5:IPGLPKDV] 377 YP_009725309_35EXON-101-115 VGTNLPLQLGFSTGV WP_035124388 CTE 8 87.5 LPLQLGFS LGLQLGFS BNN[-1.0:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0724_14876[75.0:LPLQIGFA] HU:XP_024303720.1[87.5:LGLTLGFS] MB:RUM_12040[87.5:LGLQVGFS] 378 YP_009725309_35EXON-289-303 RVDWTIEYPIIGDEL WP_035110925 CTE 8 87.5 RVDWTIEY RVDWDIEY BNN[-0.0:-0.3] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[NONE] HU:NO[NO] MB:CLOSPO_00846[87.5:RVDWNIEY] HU:NO[NO] MB:HMPREF9476_01871[87.5:RVDWNIEY] 379 YP_009725309_35EXON-289-303 RVDWTIEYPIIGDEL WP_023438388 CTE 8 87.5 IEYPIIGD IEYPIKGD BYN[0.6:-0.1] HLAI[NONE] HLAII[NONE] HU:XP_011532972.1[62.5:IKHPIVGD] MB:MBAG_01357[87.5:IEHPIIGD] HU:XP_006713262.1[75.0:IAYPLKGD] MB:HMPREF1030_06002[75.0:IEYPLQGD] 380 YP_009724396.1_ORF8-1-15 MKFLVFLGIITTVAA WP_115603869 CTE 8 87.5 GIITTVAA GIITYVAA BNN[-0.9:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_011527745.2[75.0:GIVTNVAA] MB:HMPREF9352_0631[75.0:GVITTIAA] HU:NO[NO] MB:HMPREF9156_00613[75.0:GVVTYVAA] 381 YP_009725310_RNASE-65-79 PVPEVKILNNLGVDI WP_011100742 CTE 8 87.5 ILNNLGVD ILSNLGVD BNN[-0.6:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_000531.2[75.0:IVNNLGID] MB:HMPREF9447_01226[75.0:IMNNMGVD] HU:NP_000531.2[62.5:IVNNLGID] MB:POTG_00618[87.5:VLSNLGVD] 382 YP_009725310_RNASE-65-79 PVPEVKILNNLGVDI WP_035109441 CTE 8 87.5 KILNNLGV KILNSLGV BNN[-0.9:-0.9] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0864_02515[87.5:KILNNIGV] HU:NP_001013716.2[62.5:EVLNTLGV] MB:HMPREF9442_00814[87.5:KVLNSLGV] 383 YP_009725310_RNASE-145-159 EGSVKGLQPSVGPKQ WP_011099514 CTE 8 87.5 LQPSVGPK LQPSVGVK BYY[0.6:1.3] HLAI[NONE] HLAII[NONE] HU:NP_996743.1[75.0:LEPAVGPK] MB:CAMGR0001_1922[75.0:FKPSVGPK] HU:NO[NO] MB:HMPREF0557_02046[87.5:VQPSVGVK] 384 YP_009724391.1_ORF3a-241-255 EEHVQIHTIDGSSGV WP_000141499.1 SPN 10 80.0 IHTIDGSSGV IHTNDHSSGV BYY[0.9:0.6] HLAI[NONE] HLAII[NONE] HU:NP_803237.3[60.0:HILDGGSGV] MB:HMPREF0204_14958[80.0:IHTIDDGSGV] HU:NO[NO] MB:HMPREF9398_1065[100.0:IHTNDHSSGV] 385 YP_009724391.1_ORF3a-45-59 WLIVGVALLAVFQSA WP_165842651.1 SPN 8 100.0 LIVGVALL LIVGVALL BNN[-1.9:-1.9] HLAI[NONE] HLAII[NONE] HU:NP_002204.2[75.0:LLVGLALL] MB:NO[NO] HU:NP_002204.2[75.0:LLVGLALL] MB:NO[NO] 386 YP_009724391.1_ORF3a-101-115 LEAPFLYLYALVYFL WP_000119900.1 SPN 8 87.5 LYALVYFL LYALVFFL BNN[-2.9:-2.5] HLAI[HLA-A*23:01, HLA-A*24:02] HLAII[NONE] HU:NP_001353772.1[75.0:LYVLTYFL] MB:HMPREF1247_1321[75.0:LYALTYFM] HU:NP_001353772.1[62.5:LYVLTYFL] MB:CAPSP0001_1130[87.5:LYAVVFFL] 387 YP_009725307_POL-53-67 CCRFQEKDEDDNLID WP_001200076.1 SPN 10 80.0 EKDEDDNLID EKDEVDDLID BYY[0.7:1.3] HLAI[NONE] HLAII[NONE] HU:NP_001273456.2[70.0:EKDEEEALID] MB:HMPREF1214_02612[80.0:KDEDDNLI] HU:XP_024308743.1[70.0:KDELNDLID] MB:HMPREF0851_00687[100.0:EKDEVDDLID] 388 YP_009725307_POL-817-831 TMLVKQGDDYVYLPY WP_000757725.1 SPN 10 80.0 VKQGDDYVYL LKQGDDYFYL BNY[0.1:0.4] HLAI[HLA-A*02:01, HLA-A*23:01, HLA-A*24:02, HLA-B*40:01] HLAII[NONE] HU:NP_004136.2[60.0:LKQPEDYFYL] MB:RTO_25000[80.0:KQGDDYVY] HU:NP_004136.2[80.0:LKQPEDYFYL] MB:PNI0076_00497[100.0:LKQGDDYFYL] 389 YP_009725307_POL-821-835 KQGDDYVYLPYPDPS WP_000757725.1 SPN 9 88.9 KQGDDYVYL KQGDDYFYL BNY[0.3:0.5] HLAI[HLA-A*02:01, HLA-A*23:01, HLA-A*24:02, HLA-B*40:01] HLAII[NONE] HU:XP_005245370.1[66.7:KPGDDYSY] MB:RTO_25000[88.9:KQGDDYVY] HU:NP_004136.2[77.8:KQPEDYFYL] MB:HMPREF1112_0418[100.0:KQGDDYFYL] 390 YP_009725307_POL-81-95 QHEETIYNLLKDCPA WP_001039991.1 SPN 8 87.5 EETIYNLL EETGYNLL BNN[0.2:-0.7] HLAI[HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:NO[NO] MB:HMPREF9061_01508[87.5:EHTIYNLL] HU:XP_011529998.1[62.5:EKTGYNMV] MB:HMPREF8577_1988[100.0:EETGYNLL] 391 YP_009725307_POL-137-151 GNCDTLKEILVTYNC WP_000628392.1 SPN 8 87.5 EILVTYNC EILSTYNC BNN[-0.5:-1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1048_0438[87.5:EILSTYNC] HU:NP_001106207.1[75.0:EILSYHNC] MB:HMPREF0837_10573[100.0:EILSTYNC] 392 YP_009725307_POL-465-479 DIRQLLFVVEVVDKY WP_000392544.1 SPN 8 87.5 LLFVVEVV LLFVVEEV BNN[-1.8:-2.3] HLAI[NONE] HLAII[NONE] HU:NP_116179.2[75.0:LLFLAEVV] MB:NO[NO] HU:NO[NO] MB:NO[NO] 393 YP_009725307_POL-493-507 VIVNNLDKSAGFPFN WP_001180963.1 SPN 8 87.5 LDKSAGFP LDKSAIFP BNY[-0.1:0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9331_00226[87.5:LDKSLGFP] HU:XP_016885459.1[75.0:LDKSGLFP] MB:PNI0446_00811[100.0:LDKSAIFP] 394 YP_009725303_NSP7-49-63 FEKMVSLLSVLLSMQ WP_001154147.1 SPN 10 80.0 VSLLSVLLSM ISILSVLLSM BNN[-2.1:-2.1] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*11:01, HLA-DRB1*15:01] HU:XP_011519162.1[60.0:TLLSAILSM] MB:HMPREF1526_00294[80.0:LLSVLLSM] HU:NP_001010883.2[70.0:SILKVLISM] MB:HMPREF1113_1631[100.0:ISILSVLLSM] 395 YP_009725301_3CPR-217-231 RWFLNRFTTTLNDFN WP_000390046.1 SPN 8 87.5 TTTLNDFN TMTLNDFN BNN[-0.3:0.2] HLAI[NONE] HLAII[NONE] HU:NP_001120.3[62.5:TGTINDFS] MB:NO[NO] HU:XP_016865124.1[62.5:TMSVSDFN] MB:HMPREF9389_2244[100.0:TMTLNDFN] 396 YP_009725311_2ORMT-285-298 NNRVVISSDVLVNN WP_000763052.1 SPN 8 87.5 SSDVLVNN SVDVLVNN BNN[-0.7:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:EDWATA_02495[87.5:SSDVLLNN] HU:NO[NO] MB:HMPREF9718_03613[100.0:SVDVLVNN] 397 YP_009725302_NSP6-13-27 WLLLTILTSLLVLVQ WP_000017793.1 SPN 10 80.0 TILTSLLVLV TILISLLTLV BNN[-2.3:-2.1] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*15:01] HU:XP_011543032.1[60.0:VITSLLVL] MB:HMPREF0501_00515[80.0:MLTSLLVLV] HU:XP_011518202.1[70.0:ISVSLLTLV] MB:PNI0446_00634[100.0:TILISLLTLV] 398 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_000744557.1 SPN 10 80.0 LQGPPGTGKS LEGPPGTGKT BYY[2.3:2.2] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:XP_011512465.1[90.0:LHGPPGTGKT] MB:BSHG_3935[100.0:LEGPPGTGKT] 399 YP_009725308_HEL-517-531 SQNAVASKILGLPTQ WP_000638907.1 SPN 10 80.0 VASKILGLPT VASKILGNPS BNN[0.1:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_006062.1[70.0:SSKILGLP] MB:HMPREF9944_01577[70.0:LASKVLGLP] HU:XP_016874595.1[70.0:ALKILGNPA] MB:PNI0159_01657[100.0:VASKILGNPS] 400 YP_009725308_HEL-53-67 PGCDVTDVTQLYLGG WP_000473008.1 SPN 8 87.5 TDVTQLYL TDVSQLYL BNN[-0.5:-0.5] HLAI[HLA-A*01:01] HLAII[NONE] HU:NO[NO] MB:HMPREF9095_1545[87.5:TDVKQLYL] HU:XP_016859471.1[75.0:SDVDQLYL] MB:ENTCAN_09013[87.5:TDVAQLYL] 401 YP_009725308_HEL-273-287 GMQKYSTLQGPPGTG WP_000744557.1 SPN 8 87.5 LQGPPGTG LEGPPGTG BYY[2.4:2.3] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[87.5:IQGPPGTG] MB:HMPREF1068_02855[100.0:LQGPPGTG] HU:XP_011512465.1[87.5:LHGPPGTG] MB:BSHG_3935[100.0:LEGPPGTG] 402 YP_009725308_HEL-497-511 REFLTRNPAWRKAVF WP_000628991.1 SPN 8 87.5 EFLTRNPA EFLYRNPA BNN[-0.3:0.2] HLAI[NONE] HLAII[NONE] HU:NP_001355795.1[75.0:EFLSRGPA] MB:HMPREF0077_1984[75.0:EFLSKNPA] HU:NP_001354814.1[50.0:DFIFKNPA] MB:PNI0446_01098[100.0:EFLYRNPA] 403 YP_009725297_LP-85-99 MVELVAELEGIQYGR WP_000639657.1 SPN 10 80.0 LVAELEGIQY FLAELEGIQY BNN[-0.6:-0.5] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[NONE] HU:NP_076962.2[60.0:ADVEGIQY] MB:HMPREF9469_04931[80.0:AELEGIQY] HU:XP_011512365.1[70.0:LVSLEGIQY] MB:HMPREF1112_0429[100.0:FLAELEGIQY] 404 YP_009725298_NSP2-265-279 GLNDNLLEILQKEKV WP_000010163.1 SPN 9 88.9 LNDNLLEIL VNDNLLEIL BNN[-1.0:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_001933.2[77.8:LNSNLLEI] MB:HMPREF8571_0021[88.9:VNDNLLEIL] HU:XP_024306374.1[77.8:NDDLLEIL] MB:HMPREF8571_0021[100.0:VNDNLLEIL] 405 YP_009725298_NSP2-593-607 AVEAPLVGTPVCING WP_001152899.1 SPN 9 88.9 VGTPVCING VGTPYCING BYN[0.9:0.0] HLAI[NONE] HLAII[NONE] HU:NP_000288.1[66.7:LGTPVGLNG] MB:PNI0446_00136[88.9:VGTPYCING] HU:NP_758872.1[66.7:IGTPYQFNG] MB:PNI0446_00136[100.0:VGTPYCING] 406 YP_009725298_NSP2-17-31 PLECIKDLLARAGKA WP_000963680.1 SPN 8 87.5 DLLARAGK DLLARADK BNN[-0.2:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0177_02019[87.5:DLIARAGK] HU:XP_024306763.1[87.5:DLLAAADK] MB:HMPREF1046_1499[100.0:DLLARADK] 407 YP_009725298_NSP2-445-459 KPVLDWLEEKFKEGV WP_001810489.1 SPN 8 87.5 LEEKFKEG LEEKFKKG BNY[0.3:0.4] HLAI[NONE] HLAII[NONE] HU:NP_001309413.1[75.0:LEKKLKEG] MB:HMPREF1112_2098[87.5:LEEKFKKG] HU:NP_004488.2[87.5:LEEKVKKG] MB:HMPREF1112_2098[100.0:LEEKFKKG] 408 YP_009724393.1_MP-129-143 LTRPLLESELVIGAV WP_001113205.1 SPN 9 88.9 PLLESELVI PLLESGLVI BNN[-0.7:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_024309310.1[77.8:LLESELVV] MB:HMPREF0724_11843[88.9:PLVESELVI] HU:NP_005178.4[66.7:PVLESGLL] MB:HMPREF8577_1764[100.0:PLLESGLVI] 409 YP_009724393.1_MP-41-55 NRNRFLYIIKLIFLW WP_000835622.1 SPN 8 87.5 LYIIKLIF LYIISLIF BNN[-2.7:-2.8] HLAI[HLA-A*23:01, HLA-A*24:02] HLAII[NONE] HU:NP_006624.2[75.0:LYLAKLIF] MB:HMPREF9447_00521[87.5:LYIIPLIF] HU:XP_011536360.1[62.5:LYLIQLVF] MB:HMPREF9447_00521[87.5:LYIIPLIF] 410 YP_009724393.1_MP-133-147 LLESELVIGAVILRG WP_001113205.1 SPN 8 87.5 LLESELVI LLESGLVI BNN[-1.1:-1.1] HLAI[NONE] HLAII[NONE] HU:XP_006711250.1[87.5:LLESELVV] MB:NO[NO] HU:NO[NO] MB:HMPREF8577_1764[100.0:LLESGLVI] 411 YP_009724393.1_MP-145-159 LRGHLRIAGHHLGRC WP_000278532.1 SPN 8 87.5 IAGHHLGR IIGHHLGR BNN[-0.8:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9954_1228[87.5:IVGHHLGR] HU:NO[NO] MB:HMPREF0851_00341[100.0:IIGHHLGR] 412 YP_009725299_NSP3-661-675 SPDAVTAYNGYLTSS WP_078063921.1 SPN 10 80.0 VTAYNGYLTS VTTYQGYLTS BNN[0.2:0.1] HLAI[NONE] HLAII[HLA-DRB1*15:01] HU:XP_011524280.1[60.0:VSSYGGYLT] MB:HMPREF9958_0638[80.0:VTTYQGYLTS] HU:XP_011524280.1[60.0:VSSYGGYLT] MB:HMPREF9958_0638[100.0:VTTYQGYLTS] 413 YP_009725299_NSP3-1781-1795 SSTFNVPMEKLKTLV WP_000991674.1 SPN 10 80.0 NVPMEKLKTL NVPMERLKEL BNN[-0.1:-0.1] HLAI[HLA-B*07:02, HLA-B*08:01, HLA-B*35:01] HLAII[NONE] HU:XP_016855795.1[60.0:HIPMEKLK] MB:HMPREF9950_0193[80.0:NVPMERLKEL] HU:NP_001349792.1[60.0:NIPLEMLREL] MB:HMPREF9180_1456[100.0:NVPMERLKEL] 414 YP_009725299_NSP3-281-295 VGGSCVLSGHNLAKH WP_000706826.1 SPN 8 87.5 VLSGHNLA VLSGLNLA BNN[-0.9:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1322_0508[87.5:VLSAHNLA] HU:XP_005263415.1[75.0:IISGLNLA] MB:HMPREF1149_1842[100.0:VLSGLNLA] 415 YP_009725299_NSP3-325-339 VLLAPLLSAGIFGAD WP_000745378.1 SPN 8 87.5 LLSAGIFG LLSAIIFG BNN[-1.9:-0.9] HLAI[NONE] HLAII[NONE] HU:XP_011513022.1[87.5:LYSAGIFG] MB:CLOHIR_01837[100.0:LLSAGIFG] HU:NP_002476.2[62.5:LSSAVVFG] MB:HMPREF0847_00904[87.5:LLSAIVFG] 416 YP_009725299_NSP3-601-615 GARFYFYTSKTTVAS WP_000742225.1 SPN 8 87.5 YFYTSKTT YNYTSKTT BYN[0.9:0.2] HLAI[NONE] HLAII[NONE] HU:NP_937983.2[50.0:FFYVTETT] MB:NO[NO] HU:XP_024308685.1[62.5:YKYTYRTT] MB:PNI0427_01649[100.0:YNYTSKTT] 417 YP_009725299_NSP3-665-679 VTAYNGYLTSSSKTP WP_000725742.1 SPN 8 87.5 GYLTSSSK GYLTHSSK BNY[0.2:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1058_01076[87.5:GFLTSSSK] HU:NP_065186.3[62.5:GFLEHSNK] MB:HMPREF9184_00370[100.0:GYLTHSSK] 418 YP_009725299_NSP3-1113-1127 VCDNIKFADDLNQLT WP_001032523.1 SPN 8 87.5 FADDLNQL FADYLNQL BNN[-0.7:-0.0] HLAI[HLA-A*01:01] HLAII[NONE] HU:NP_057581.2[75.0:FADDLHNL] MB:CLOSCI_00945[87.5:FADDLNHL] HU:NP_004516.2[62.5:YSDYLNQM] MB:HMPREF9965_0597[100.0:FADYLNQL] 419 YP_009725299_NSP3-1521-1535 YVLGLAAIMQLFFSY WP_000291874.1 SPN 8 87.5 AAIMQLFF AAIMQDFF BNN[-1.0:-2.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9962_0703[87.5:AAIMQTFF] HU:XP_005250500.1[62.5:GAILQSFF] MB:HMPREF9178_1254[100.0:AAIMQDFF] 420 YP_009725299_NSP3-1601-1615 TRVECTTIVNGVRRS WP_000835659.1 SPN 8 87.5 TIVNGVRR TIVNGVER BNN[-0.0:-0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9286_1488[87.5:TIVDGVRR] HU:NP_001276014.1[75.0:TTVNGLER] MB:PNI0427_01163[100.0:TIVNGVER] 421 YP_009725299_NSP3-1793-1807 TLVATAEAELAKNVS WP_001291640.1 SPN 8 87.5 TAEAELAK TAEAFLAK BNY[-0.5:0.5] HLAI[NONE] HLAII[NONE] HU:NP_001166028.1[75.0:TAEAELSR] MB:HMPREF9709_00208[87.5:TAEAEIAK] HU:NP_004374.1[75.0:TAQAFLAE] MB:HMPREF1124_1021[100.0:TAEAFLAK] 422 YP_009725304_NSP8-37-51 KLKKSLNVAKSEFDR WP_000688713.1 SPN 8 87.5 KLKKSLNV KLKLSLNV BNN[-1.2:-0.4] HLAI[NONE] HLAII[NONE] HU:XP_011535247.1[87.5:KLKKSLKV] MB:ANACOL_00409[87.5:RLKKSLNV] HU:XP_011523389.1[62.5:KMKMQLNV] MB:PNI0446_00026[100.0:KLKLSLNV] 423 YP_009724392.1_ENV-21-35 LAFVVFLLVTLAILT WP_000185363.1 SPN 8 87.5 LLVTLAIL LLVTGAIL BNN[-1.3:-2.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9710_03912[100.0:LLVTLAIL] HU:NP_001258152.2[75.0:LLITGATL] MB:HMPREF1344_00933[100.0:LLVTGAIL] 424 YP_009724390.1_SPIKE-257-271 GWTAGAAAYYVGYLQ WP_000424414.1 SPN 9 88.9 AGAAAYYVG AGAAARYVG BNN[0.3:0.1] HLAI[NONE] HLAII[NONE] HU:NP_060662.2[77.8:SGAAAYYSG] MB:HMPREF9439_00672[77.8:GAAAYYVA] HU:NP_001182484.1[66.7:GAAAHYTG] MB:PNI0446_01459[100.0:AGAAARYVG] 425 YP_009724390.1_SPIKE-1-15 MFVFLVLLPLVSSQC WP_000182582.1 SPN 8 87.5 VLLPLVSS VLLGLVSS BNN[-1.5:-1.3] HLAI[NONE] HLAII[NONE] HU:XP_005256356.1[75.0:VLLPLLES] MB:HMPREF9441_02743[87.5:VLLPLVTS] HU:XP_006722354.1[87.5:VLLGLVVS] MB:NO[NO] 426 YP_009724390.1_SPIKE-61-75 NVTWFHAIHVSGTNG WP_000464380.1 SPN 8 87.5 IHVSGTNG IHVTGTNG BYY[0.5:0.6] HLAI[NONE] HLAII[NONE] HU:NP_004948.4[75.0:IHVTGTKG] MB:GCWU000323_00806[87.5:IHISGTNG] HU:NP_004948.4[87.5:IHVTGTKG] MB:BIFGAL_02891[100.0:IHVTGTNG] 427 YP_009724390.1_SPIKE-193-207 VFKNIDGYFKIYSKH WP_000651183.1 SPN 8 87.5 GYFKIYSK GYFDIYSK BNN[-0.5:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_003798.2[75.0:GYYYIYSK] MB:NO[NO] HU:NP_001171536.2[50.0:GYYNVYAK] MB:HMPREF0973_02353[100.0:GYFDIYSK] 428 YP_009724390.1_SPIKE-261-275 GAAAYYVGYLQPRTF WP_000424414.1 SPN 8 87.5 GAAAYYVG GAAARYVG BNN[0.2:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_060662.2[87.5:GAAAYYSG] MB:HMPREF9439_00672[87.5:GAAAYYVA] HU:NP_001182484.1[75.0:GAAAHYTG] MB:PNI0446_01459[100.0:GAAARYVG] 429 YP_009724390.1_SPIKE-301-315 CTLKSFTVEKGIYQT WP_000173358.1 SPN 8 87.5 FTVEKGIY FTVEKGDY BYN[0.6:-0.1] HLAI[HLA-A*01:01] HLAII[NONE] HU:NP_997191.2[62.5:FSMEKGVY] MB:HMPREF0988_00394[87.5:FTIEKGIY] HU:XP_011528204.1[75.0:FVLEKGDY] MB:HMPREF1042_0502[100.0:FTVEKGDY] 430 YP_009724390.1_SPIKE-501-515 NGVGYQPYRVVVLSF WP_000884256.1 SPN 8 87.5 PYRVVVLS PYRVVALS BNN[-0.8:-1.2] HLAI[NONE] HLAII[NONE] HU:XP_011524857.1[87.5:PRRVVVLS] MB:HMPREF1211_01715[87.5:PYRIVVLS] HU:NP_054733.2[75.0:PIRIVALS] MB:HMPREF9422_1836[100.0:PYRVVALS] 431 YP_009724390.1_SPIKE-589-603 PCSFGGVSVITPGTN WP_000963680.1 SPN 8 87.5 VSVITPGT VQVITPGT BYY[0.4:0.4] HLAI[NONE] HLAII[NONE] HU:NP_065170.2[62.5:ISVLSPGT] MB:HMPREF9130_0789[87.5:VSVLTPGT] HU:XP_024306427.1[87.5:VQVETPGT] MB:HMPREF0428_00953[100.0:VQVITPGT] 432 YP_009724390.1_SPIKE-613-627 QDVNCTEVPVAIHAD WP_001019003.1 SPN 8 87.5 VPVAIHAD VPVAIHLD BNN[-0.8:-0.3] HLAI[NONE] HLAII[NONE] HU:XP_016857233.1[62.5:LPAAVHAD] MB:HMPREF1152_1564[87.5:VPVAVHAD] HU:XP_011523388.1[75.0:VPVLFHLD] MB:HMPREF1383_00290[100.0:VPVAIHLD] 433 YP_009725300_NSP4-277-291 ALDISASIVAGGIVA WP_000730333.1 SPN 8 87.5 IVAGGIVA IVAPGIVA BNN[-0.2:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_005266130.1[87.5:LVAGGIVA] MB:HMPREF9538_03611[87.5:LVAGGIVA] HU:XP_006717037.1[62.5:IIAPGVEA] MB:HMPREF9703_00639[100.0:IVAPGIVA] 434 YP_009725300_NSP4-345-359 IYLYLTFYLTNDVSF WP_000682783.1 SPN 8 87.5 LTFYLTND LTFYLDND BNN[-0.7:-1.0] HLAI[NONE] HLAII[NONE] HU:XP_006722498.1[62.5:MSFYLLND] MB:GEMHA0001_0797[87.5:LTFYLDND] HU:NP_060034.9[62.5:LSFFLHND] MB:GEMHA0001_0797[100.0:LTFYLDND] 435 YP_009725300_NSP4-449-463 NKYKYFSGAMDTTSY WP_000862415.1 SPN 8 87.5 YFSGAMDT YFSGAMLT BNN[-0.6:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9401_1920[75.0:YFTGAFDT] HU:XP_024305475.1[87.5:YTSGAMLT] MB:HMPREF9958_1966[100.0:YFSGAMLT] 436 YP_009724397.2_NP-153-167 NNAAIVLQLPQGTTL WP_000099031.1 SPN 8 87.5 QLPQGTTL QLPQGTDL BYY[1.1:1.0] HLAI[NONE] HLAII[NONE] HU:XP_024307603.1[62.5:QIPQGSSL] MB:HMPREF0017_01879[100.0:QLPQGTTL] HU:XP_011509520.1[75.0:RFPQGTDL] MB:HMPREF1111_0518[100.0:QLPQGTDL] 437 YP_009724397.2_NP-245-259 TVTKKSAAEASKKPR WP_001057333.1 SPN 8 87.5 KSAAEASK ESAAEASK BYY[1.3:1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_006651.2[87.5:ESAAEAVK] MB:NO[NO] 438 YP_009724397.2_NP-393-407 TLLPAADLDDFSKQL WP_000358228.1 SPN 8 87.5 LDDFSKQL LDDFSQQL BNN[0.1:0.0] HLAI[NONE] HLAII[NONE] HU:XP_005249639.1[75.0:LDEFSKQV] MB:HMPREF0981_04014[87.5:LDDFSKKL] HU:NP_733765.1[62.5:LDEFGEQL] MB:GCWU000341_02545[87.5:LDDFGQQL] 439 YP_009725305_NSP9-33-47 NTTKGGRFVLALLSD WP_000334246.1 SPN 10 80.0 GRFVLALLSD GTPVLALLSD BNN[-0.6:-1.6] HLAI[NONE] HLAII[NONE] HU:XP_006718715.1[80.0:GHFVLATLSD] MB:CAPGI0001_2341[80.0:RFVLQLLSD] HU:NP_001350485.1[70.0:GAPVLSLLS] MB:HMPREF1117_0511[100.0:GTPVLALLSD] 440 YP_009724396.1_ORF8-45-59 WYIRVGARKSAPLIE WP_000152673.1 SPN 8 87.5 RKSAPLIE RKSAYLIE BNN[-0.6:0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9473_01360[75.0:RKSAPLVQ] HU:NO[NO] MB:HMPREF9188_01765[100.0:RKSAYLIE] 441 YP_009725310_RNASE-245-259 LGGLHLLIGLAKRFK WP_000477449.1 SPN 10 80.0 LLIGLAKRFK LCIGLAKRDK BNN[-0.6:-1.3] HLAI[NONE] HLAII[HLA-DRB1*11:01] HU:XP_011528604.1[70.0:LLVALAKRFQ] MB:HMPREF9166_0188[80.0:LIALAKRFK] HU:NP_116035.5[70.0:CLGLAKRSK] MB:HMPREF9153_1355[100.0:LCIGLAKRDK] 442 YP_009725310_RNASE-297-311 LLLDDFVEIIKSQDL WP_000566531.1 SPN 10 80.0 LLLDDFVEII LRLTDFVEII BNN[-1.3:-1.5] HLAI[HLA-A*02:01] HLAII[HLA-DRB3*01:01] HU:XP_016864075.1[70.0:IALDDFVEI] MB:HMPREF9264_0488[70.0:LDDFLEII] HU:XP_005264577.1[70.0:RLTDFVEFL] MB:PCS8203_00457[100.0:LRLTDFVEII] 443 YP_009724391.1_ORF3a-5-19 MRIFTIGTVTLKQGE WP_002225616.1 NSM 8 87.5 GTVTLKQG GTVTDKQG BYN[1.3:0.1] HLAI[NONE] HLAII[NONE] HU:NP_068800.2[87.5:GTVTKKQG] MB:HMPREF0530_1574[100.0:GTVTLKQG] HU:NP_068800.2[87.5:GTVTKKQG] MB:HMPREF9135_1627[87.5:GTVTDKEG] 444 YP_009724391.1_ORF3a-89-103 TVYSHLLLVAAGLEA WP_050542148.1 NSM 8 87.5 LVAAGLEA LVAATLEA BNN[-0.6:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_775960.4[87.5:LVAATLQA] MB:NO[NO] 445 YP_009725306_NSP10-1-15 AGNATEVPANSTVLS WP_002213540.1 NSM 8 87.5 VPANSTVL VPAHSTVL BNY[0.2:0.5] HLAI[HLA-B*07:02, HLA-B*08:01, HLA-B*35:01] HLAII[NONE] HU:XP_005263536.1[75.0:VPANSSLL] MB:HMPREF1071_04435[87.5:VPANTTVL] HU:XP_016855652.1[62.5:LPGHSTIL] MB:HMPREF0027_1316[100.0:VPAHSTVL] 446 YP_009725307_POL-25-39 GTSTDVVYRAFDIYN WP_002213898.1 NSM 8 87.5 DVVYRAFD DDVYRAFD BNN[-0.0:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_005550.2[75.0:DLVYRAED] MB:HMPREF1138_1681[87.5:DVMYRAFD] HU:NP_065806.1[75.0:DDVHRAVD] MB:HMPREF0602_1239[100.0:DDVYRAFD] 447 YP_009725307_POL-205-219 LTLDNQDLNGNWYDF WP_002247616.1 NSM 8 87.5 LDNQDLNG LDNQDENG BYY[1.7:0.7] HLAI[NONE] HLAII[NONE] HU:XP_011521040.1[75.0:IDNKDLNG] MB:CORMATOL_01823[87.5:LDDQDLNG] HU:XP_016862507.1[75.0:LDNKDDNG] MB:NEILACOT_05595[100.0:LDNQDENG] 448 YP_009725307_POL-241-255 LMPILTLTRALTAES WP_002225136.1 NSM 8 87.5 TLTRALTA TLTNALTA BNN[-0.2:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001164185.1[75.0:TLTNAVDA] MB:HMPREF1429_01399[100.0:TLTNALTA] 449 YP_009725307_POL-245-259 LTLTRALTAESHVDT WP_002224748.1 NSM 8 87.5 LTAESHVD LAAESHVD BNY[0.3:0.4] HLAI[NONE] HLAII[NONE] HU:XP_016878370.1[62.5:VTAQSHLD] MB:HMPREF9449_03064[87.5:LAAESHVD] HU:NP_599152.2[75.0:LAAEGHLD] MB:HMPREF9450_00570[100.0:LAAESHVD] 450 YP_009725303_NSP7-5-19 DVKCTSVVLLSVLQQ WP_002224907.1 NSM 10 80.0 SVVLLSVLQQ SVVLRSRLQQ BNN[-0.8:-1.7] HLAI[NONE] HLAII[HLA-DRB1*11:01] HU:NP_001313536.1[80.0:VVLWSVLQQ] MB:NO[NO] HU:XP_011540311.1[70.0:AVVLRSRLK] MB:HMPREF9016_02166[100.0:SVVLRSRLQQ] 451 YP_009724394.1_ORF6-33-47 INLIIKNLSKSLTEN WP_002216537.1 NSM 11 81.8 NLIIKNLSKSL NLITKDLSKSL BNN[-0.3:-1.0] HLAI[HLA-A*03:01, HLA-A*11:01, HLA-B*07:02, HLA-B*08:01] HLAII[HLA-DRB1*03:01, HLA-DRB1*07:01, HLA-DRB1*08:02, HLA-DRB1*12:01, HLA-DRB1*13:02, HLA-DRB3*01:01] HU:XP_005250918.1[63.6:NIFIKNLDKSI] MB:HMPREF9447_02397[72.7:IIKNLSKAL] HU:XP_006721622.1[63.6:NLVTQQLSKS] MB:HMPREF0602_0199[100.0:NLITKDLSKSL] 452 YP_009725301_3CPR-81-95 SMQNCVLKLKVDTAN WP_002224978.1 NSM 9 88.9 LKLKVDTAN LKLVVDTAN BNN[-0.6:-0.2] HLAI[NONE] HLAII[HLA-DRB1*08:02, HLA-DRB4*01:01] HU:NP_009062.2[77.8:LKLKNDTGN] MB:HMPREF9098_0196[88.9:LKLVVDTAN] HU:NP_071394.2[55.6:KEIIDTAN] MB:NEIFL0001_0486[100.0:LKLVVDTAN] 453 YP_009725301_3CPR-25-39 TTLNGLWLDDVVYCP WP_002224861.1 NSM 8 87.5 LNGLWLDD LNGLWLWD BNN[-1.3:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9144_1359[87.5:LRGLWLDD] HU:NO[NO] MB:HMPREF9554_01019[87.5:MNGLWLWD] 454 YP_009725311_2ORMT-101-115 NDFVSDADSTLIGDC WP_002225307.1 NSM 9 88.9 VSDADSTLI VSDMDSTLI BNY[0.1:1.4] HLAI[HLA-A*01:01] HLAII[NONE] HU:XP_016870103.1[66.7:ISDADKTL] MB:NEICINOT_04147[88.9:VSDMDSTLI] HU:NO[NO] MB:NEICINOT_04147[100.0:VSDMDSTLI] 455 YP_009725311_2ORMT-101-115 NDFVSDADSTLIGDC WP_002222348.1 NSM 8 87.5 NDFVSDAD NDFVSDVD BYY[0.9:0.6] HLAI[NONE] HLAII[NONE] HU:XP_006713751.1[75.0:NDFLSDKD] MB:HMPREF9098_1455[87.5:NDFVSDVD] HU:XP_006713751.1[75.0:NDFLSDKD] MB:HMPREF9098_1455[100.0:NDFVSDVD] 456 YP_009725311_2ORMT-105-119 SDADSTLIGDCATVH WP_002225307.1 NSM 8 87.5 SDADSTLI SDMDSTLI BNY[0.2:0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0874_00736[87.5:SDADSTLL] HU:NO[NO] MB:NEICINOT_04147[100.0:SDMDSTLI] 457 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_002224914.1 NSM 10 80.0 LQGPPGTGKS MMGPPGTGKS BYY[1.9:2.2] HLAI[HLA-A*03:01, HLA-A*11:01] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:XP_024302085.1[80.0:MVGPPGTGKT] MB:HMPREF0476_0105[100.0:MMGPPGTGKS] 458 YP_009725308_HEL-529-543 PTQTVDSSQGSEYDY WP_002225198.1 NSM 10 80.0 TVDSSQGSEY TVHKSQGSEY BYY[1.0:1.5] HLAI[NONE] HLAII[NONE] HU:NP_001245151.1[80.0:VDSSQFSEY] MB:HMPREF9123_2248[80.0:TVHKSQGSEY] HU:NP_001032412.2[60.0:SITKSQGSEW] MB:HMPREF9123_2248[100.0:TVHKSQGSEY] 459 YP_009725308_HEL-245-259 HYVRITGLYPTLNIS WP_002225707.1 NSM 8 87.5 TGLYPTLN TGLRPTLN BYN[1.0:0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1093_01776[87.5:TGLYPTKN] HU:NO[NO] MB:NEIFLAOT_02532[100.0:TGLRPTLN] 460 YP_009725308_HEL-281-295 QGPPGTGKSHFAIGL WP_002224914.1 NSM 8 100.0 GPPGTGKS GPPGTGKS BYY[2.6:2.6] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] 461 YP_009725297_LP-89-103 VAELEGIQYGRSGET WP_002213466.1 NSM 8 87.5 IQYGRSGE IQYGMSGE BNY[0.3:0.8] HLAI[NONE] HLAII[NONE] HU:XP_016885567.1[75.0:LQYLRSGE] MB:GCWU000341_01018[87.5:IQYGRTGE] HU:NP_002294.2[62.5:IRYGLSGK] MB:HMPREF9370_1146[100.0:IQYGMSGE] 462 YP_009724395.1_ORF7a-5-19 LFLALITLATCELYH WP_002212503.1 NSM 8 87.5 LFLALITL LFLALISL BNN[-2.7:-2.7] HLAI[NONE] HLAII[NONE] HU:XP_016881223.1[75.0:LFLALVAL] MB:HMPREF0021_02790[100.0:LFLALITL] HU:XP_016881223.1[75.0:LFLALVAL] MB:HMPREF9969_1312[87.5:LFLALVSL] 463 YP_009724395.1_ORF7a-97-111 YSPIFLIVAAIVFIT WP_002217354.1 NSM 8 87.5 IVAAIVFI IVAAILFI BNN[-2.4:-2.1] HLAI[NONE] HLAII[NONE] HU:XP_016876048.1[87.5:LVAAIVFI] MB:HMPREF0889_0380[100.0:IVAAIVFI] HU:NP_001307841.1[75.0:LVAAVLFI] MB:HMPREF0281_01354[87.5:IIAAILFI] 464 YP_009725298_NSP2-21-35 IKDLLARAGKASCTL WP_002225235.1 NSM 8 87.5 LARAGKAS LARSGKAS BYY[0.8:0.5] HLAI[NONE] HLAII[NONE] HU:NP_064711.1[87.5:LARAGKAA] MB:HMPREF9333_00528[100.0:LARAGKAS] HU:NP_064711.1[75.0:LARAGKAA] MB:HMPREF0602_1012[100.0:LARSGKAS] 465 YP_009725298_NSP2-261-275 EGSEGLNDNLLEILQ WP_002213870.1 NSM 8 87.5 NDNLLEIL NDNLMEIL BNN[-0.9:-1.1] HLAI[NONE] HLAII[NONE] HU:XP_024306374.1[87.5:NDDLLEIL] MB:HMPREF8571_0021[100.0:NDNLLEIL] HU:NP_002755.1[87.5:NDNLMELL] MB:HMPREF0016_01200[100.0:NDNLMEIL] 466 YP_009725298_NSP2-565-579 ETLPTEVLTEEVVLK WP_002222865.1 NSM 8 87.5 LTEEVVLK LTEEDVLK BNN[0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:CC1_18870[87.5:LTEEVILK] HU:NO[NO] MB:HMPREF0602_1540[100.0:LTEEDVLK] 467 YP_009724393.1_MP-157-171 GRCDIKDLPKEITVA WP_002216723.1 NSM 8 87.5 LPKEITVA LIKEITVA BNN[-0.9:0.0] HLAI[NONE] HLAII[NONE] HU:NP_001159430.1[75.0:LPKEITIS] MB:CC1_15150[75.0:LPKEVTVS] HU:NP_057526.3[62.5:LVKSVTVA] MB:HMPREF9123_2403[100.0:LIKEITVA] 468 YP_009725299_NSP3-245-259 VYLKHGGGVAGALNK WP_002218257.1 NSM 10 80.0 VYLKHGGGVA VYLKKGGLVA BNN[-0.4:0.1] HLAI[HLA-A*23:01, HLA-A*24:02, HLA-B*08:01] HLAII[NONE] HU:NP_000543.2[80.0:VKLKHGAGVA] MB:HMPREF9689_00746[80.0:YLKHGGVVA] HU:NP_001269220.1[70.0:LKKGGLYA] MB:NEIPOLOT_00613[100.0:VYLKKGGLVA] 469 YP_009725299_NSP3-465-479 APYIVGDVVQEGVLT WP_002219640.1 NSM 10 80.0 VGDVVQEGVL LGYVVQEGVL BNY[-0.5:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9095_1782[90.0:VGDVVQGGVL] HU:NO[NO] MB:NEIPOLOT_02146[100.0:LGYVVQEGVL] 470 YP_009725299_NSP3-1421-1435 CLGSLIYSTAALGVL WP_002224851.1 NSM 10 80.0 IYSTAALGVL IGSTAALGYL BNN[-0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_001177909.1[70.0:YSTASLGV] MB:HMPREF0322_00742[70.0:IYQTAALGIV] HU:XP_005271973.1[60.0:VGTTASFGYL] MB:NEICINOT_04303[100.0:IGSTAALGYL] 471 YP_009725299_NSP3-1121-1135 DDLNQLTGYKKPASR WP_002225727.1 NSM 9 88.9 TGYKKPASR TGYKKPAAR BYY[1.3:1.4] HLAI[HLA-A*03:01] HLAII[NONE] HU:NP_066979.2[66.7:TGWKSPAS] MB:NEILACOT_05573[88.9:TGYKKPAAR] HU:NP_000531.2[66.7:TGYMEPALR] MB:NEILACOT_05573[100.0:TGYKKPAAR] 472 YP_009725299_NSP3-193-207 QLEMELTPVVQTIEV WP_002222848.1 NSM 8 87.5 PVVQTIEV PVVQTVEV BNN[-0.0:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_016882988.1[62.5:PVIQTLDV] MB:NEIPOLOT_02111[87.5:PVVQTVEV] HU:NP_001034859.2[75.0:PAVKTVEV] MB:NEIPOLOT_02111[100.0:PVVQTVEV] 473 YP_009725299_NSP3-221-235 YIKNADIVEEAKKVK WP_010980816.1 NSM 8 87.5 DIVEEAKK DYVEEAKK BYY[0.8:0.5] HLAI[NONE] HLAII[NONE] HU:XP_024307950.1[75.0:DIVQESKK] MB:FVAG_01691[100.0:DIVEEAKK] HU:NP_001009984.1[75.0:DYVEEANR] MB:HMPREF0602_2446[100.0:DYVEEAKK] 474 YP_009725299_NSP3-237-251 TVVVNAANVYLKHGG WP_002244057.1 NSM 8 87.5 TVVVNAAN TVVVNAAE BNN[-0.2:-0.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0880_00396[87.5:SVVVNAAN] HU:NP_597676.3[75.0:TIVVNAGE] MB:NO[NO] 475 YP_009725299_NSP3-245-259 VYLKHGGGVAGALNK WP_002216541.1 NSM 8 87.5 GGVAGALN GGVAGALS BYY[0.4:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:CLOSTASPAR_05755[100.0:GGVAGALN] HU:NP_998816.1[75.0:GGIAGAVS] MB:CLOSTMETH_02168[87.5:GGVAGALA] 476 YP_009725299_NSP3-493-507 EMLAKALRKVPTDNY WP_002212596.1 NSM 8 87.5 KALRKVPT KALRKVGT BNN[-0.2:0.0] HLAI[NONE] HLAII[NONE] HU:XP_011535638.1[75.0:KGVRKVPT] MB:HMPREF9718_02125[100.0:KALRKVPT] HU:NP_001189367.1[75.0:KALRSLGT] MB:HMPREF9129_1965[100.0:KALRKVGT] 477 YP_009725299_NSP3-557-571 LREMLAHAEETRKLM WP_002225191.1 NSM 8 87.5 AEETRKLM AEETIKLM BNN[-0.3:0.3] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:XP_024306572.1[87.5:AEETKKLM] MB:BSGG_0819[87.5:SEETRKLM] HU:XP_024306572.1[87.5:AEETKKLM] MB:HMPREF0602_0921[100.0:AEETIKLM] 478 YP_009725299_NSP3-1385-1399 VKSVGKFCLEASFNY WP_002215336.1 NSM 8 87.5 GKFCLEAS GKFNLEAS BNN[-0.1:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:CC1_29270[75.0:GKFCLEGT] HU:NO[NO] MB:HMPREF0602_2191[100.0:GKFNLEAS] 479 YP_009725299_NSP3-1669-1683 SSYIVDSVTVKNGSI WP_002213307.1 NSM 8 87.5 DSVTVKNG DIVTVKNG BNY[-0.1:0.5] HLAI[NONE] HLAII[NONE] HU:XP_011518010.1[87.5:DSVTVRNG] MB:HMPREF1450_01354[87.5:DSVIVKNG] HU:NP_001362749.1[62.5:DVITVSNG] MB:HMPREF1218_0729[100.0:DIVTVKNG] 480 YP_009725299_NSP3-1745-1759 QLMCQPILLLDQALV WP_010980767.1 NSM 8 87.5 PILLLDQA PILLLDEA BNN[-1.3:-1.4] HLAI[NONE] HLAII[NONE] HU:XP_011536400.1[62.5:PVLILDEA] MB:CL2_24450[87.5:PILLLDEA] HU:XP_011536400.1[75.0:PVLILDEA] MB:NEISUBOT_03410[100.0:PILLLDEA] 481 YP_009725299_NSP3-1905-1919 EQLRKQIRSAAKKNN WP_002219640.1 NSM 8 87.5 EQLRKQIR EQLRRQIR BNN[-0.3:-0.2] HLAI[NONE] HLAII[NONE] HU:XP_005257841.1[75.0:EQLRRQVR] MB:HMPREF1042_0382[87.5:EQLRKEIR] HU:XP_005257841.1[87.5:EQLRRQVR] MB:NEIFLAOT_00836[100.0:EQLRRQIR] 482 YP_009724392.1_ENV-45-59 NIVNVSLVKPSFYVY WP_002236620.1 NSM 10 80.0 VNVSLVKPSF VNVSLVDLSF BNN[-1.1:-0.4] HLAI[HLA-A*23:01, HLA-B*35:01] HLAII[NONE] HU:NP_005472.2[70.0:VTVSLLKPS] MB:EDWATA_00655[80.0:VAVTLVKPSF] HU:NP_001350540.1[70.0:DVSLVDLGF] MB:NEILACOT_04356[100.0:VNVSLVDLSF] 483 YP_009724390.1_SPIKE-177-191 MDLEGKQGNFKNLRE WP_002225341.1 NSM 10 80.0 KQGNFKNLRE KQGNKKELRE BYN[1.0:0.3] HLAI[NONE] HLAII[NONE] HU:XP_016865171.1[70.0:EGRFKNLRE] MB:HMPREF0023_2949[80.0:QGNFKELRE] HU:XP_005270470.1[60.0:KQGNKNDL] MB:HMPREF0604_00974[100.0:KQGNKKELRE] 484 YP_009724390.1_SPIKE-877-891 LLAGTITSGWTFGAG WP_002225792.1 NSM 8 87.5 SGWTFGAG SGWTIGAG BYY[1.2:1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1032_03771[75.0:TGWTFSAG] HU:XP_016879062.1[75.0:SGWRIGKG] MB:HMPREF1051_0508[100.0:SGWTIGAG] 485 YP_009724397.2_NP-209-223 RMAGNGGDAALALLL WP_002224944.1 NSM 10 80.0 AGNGGDAALA AGNGGDLNLA BYY[0.8:1.2] HLAI[NONE] HLAII[NONE] HU:XP_011532232.1[60.0:AGGGGDSA] MB:HMPREF0629_01080[80.0:AGNGGDGAVA] HU:XP_011516707.1[60.0:GNCGDINL] MB:HMPREF9016_01229[100.0:AGNGGDLNLA] 486 YP_009724397.2_NP-37-51 SKQRRPQGLPNNTAS WP_002221436.1 NSM 8 87.5 GLPNNTAS GLPNNTFS BYY[0.9:1.4] HLAI[NONE] HLAII[NONE] HU:XP_016861618.1[75.0:GLPNDTLS] MB:HMPREF9442_00421[87.5:GLPNNTVS] HU:XP_016861621.1[75.0:GLPNDTLS] MB:HMPREF9442_00421[87.5:GLPNNTVS] 487 YP_009724397.2_NP-153-167 NNAAIVLQLPQGTTL WP_002221872.1 NSM 8 87.5 NAAIVLQL NAAYVLQL BNN[-1.1:-1.5] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_004948.4[75.0:NAALALQL] MB:NO[NO] HU:NP_001030.2[75.0:NAAYSLQI] MB:NEICINOT_03797[100.0:NAAYVLQL] 488 YP_009724397.2_NP-305-319 AQFAPSASAFFGMSR WP_002225616.1 NSM 8 87.5 QFAPSASA QFAPSSSA BYY[1.2:1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:XP_016861040.1[87.5:QFAPFSSA] MB:NO[NO] 489 YP_009724397.2_NP-341-355 DKDPNFKDQVILLNK WP_002225482.1 NSM 8 87.5 KDQVILLN KDQVILVN BNN[-1.0:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_612362.2[87.5:KDQVVLLN] MB:CLOSTASPAR_03723[87.5:RDQVILLN] HU:NP_612362.2[75.0:KDQVVLLN] MB:HMPREF9371_2134[100.0:KDQVILVN] 490 YP_009725305_NSP9-33-47 NTTKGGRFVLALLSD WP_002217440.1 NSM 9 88.9 KGGRFVLAL KGGRFALAL BNN[-0.6:-1.0] HLAI[NONE] HLAII[NONE] HU:XP_011510519.1[77.8:GGRIVLAL] MB:CLOSTMETH_01444[77.8:KGGRYVLA] HU:NP_002654.3[66.7:QAGRFALSL] MB:HMPREF9081_2239[77.8:GGKFALAL] 491 YP_009725305_NSP9-29-43 LAYYNTTKGGRFVLA WP_002217440.1 NSM 8 87.5 KGGRFVLA KGGRFALA BNN[-0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:XP_011542021.1[75.0:KGGRFTKA] MB:CLOSTMETH_01444[87.5:KGGRYVLA] HU:NO[NO] MB:OFBG_01734[87.5:KGGRLALA] 492 YP_009725305_NSP9-37-51 GGRFVLALLSDLQDL WP_002217440.1 NSM 8 87.5 GGRFVLAL GGRFALAL BNN[-0.9:-1.4] HLAI[NONE] HLAII[NONE] HU:XP_011510519.1[87.5:GGRIVLAL] MB:HMPREF0183_0029[87.5:GGRFVLSL] HU:NP_002654.3[75.0:AGRFALSL] MB:HMPREF7545_1292[87.5:GGKFALAL] 493 YP_009725309_35EXON-361-375 YKIEELFYSYATHSD WP_002224931.1 NSM 10 80.0 EELFYSYATH EEDFNSYATH BYN[0.7:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_008835.5[60.0:EEVFRPYAKH] MB:HMPREF1238_1385[90.0:EELFRSYATH] HU:NP_077010.1[70.0:EESFNLQATH] MB:HMPREF9702_03050[100.0:EEDFNSYATH] 494 YP_009725309_35EXON-309-323 CRKVQHMVVKAALLA WP_002222873.1 NSM 8 87.5 VVKAALLA VGKAALLA BNN[-0.7:-1.2] HLAI[NONE] HLAII[NONE] HU:XP_011541883.1[87.5:VVKAALVA] MB:NO[NO] HU:XP_016872850.1[75.0:VGKSALLS] MB:NO[NO] 495 YP_009724396.1_ORF8-5-19 VFLGIITTVAAFHQE WP_002221798.1 NSM 8 87.5 IITTVAAF IITTVALF BNN[-1.4:-0.9] HLAI[NONE] HLAII[NONE] HU:NP_689677.1[75.0:IVTVVAAF] MB:NO[NO] HU:XP_016878921.1[75.0:IITTEALY] MB:HMPREF1204_03423[87.5:ILTTVALF] 496 YP_009725310_RNASE-133-147 LFRNARNGVLITEGS WP_010980875.1 NSM 10 80.0 ARNGVLITEG AGAGVLITEG BNN[-0.2:-0.3] HLAI[NONE] HLAII[NONE] HU:NP_056953.2[60.0:KDGVLISEG] MB:CAPSP0001_2517[80.0:ARNGVLITQ] HU:NP_001281261.1[80.0:GAGCLITEG] MB:HMPREF0005_00591[100.0:AGAGVLITEG] 497 YP_009725310_RNASE-153-167 PSVGPKQASLNGVTL WP_002225235.1 NSM 8 87.5 ASLNGVTL ASLAGVTL BNN[-0.4:-0.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF0602_1012[100.0:ASLAGVTL] 498 YP_009725310_RNASE-157-171 PKQASLNGVTLIGEA WP_002222440.1 NSM 8 87.5 SLNGVTLI SLNGNTLI BNN[-0.0:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9447_03740[87.5:SVNGVTLI] HU:NO[NO] MB:NEILACOT_04864[100.0:SLNGNTLI] 499 YP_009725310_RNASE-233-247 EHIVYGDFSHSQLGG WP_002242629.1 NSM 8 87.5 DFSHSQLG DFSHSDLG BYY[1.1:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HCMG_01389[87.5:DFSHSALG] HU:XP_016855680.1[75.0:DKSHSDIG] MB:HMPREF9294_0489[87.5:DFSHSDMG] 500 YP_009724391.1_ORF3a-61-75 KIITLKKRWQLALSK WP_005691796.1 HIN 8 87.5 KKRWQLAL KKSWQLAL BNN[-0.5:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9071_0592[75.0:KERWQVAL] HU:NP_001095132.1[75.0:KKCWALAL] MB:HMPREF9095_1427[100.0:KKSWQLAL] 501 YP_009724391.1_ORF3a-189-203 YTEKWESGVKDCVVL WP_005693266.1 HIN 8 87.5 KWESGVKD KRESGVKD BYY[1.2:0.9] HLAI[NONE] HLAII[NONE] HU:NP_000480.3[62.5:KWQEGLKD] MB:HMPREF9126_0522[75.0:KWESAIKD] HU:NP_000325.4[62.5:KKESGIDD] MB:HMPREF1053_0646[100.0:KRESGVKD] 502 YP_009725306_NSP10-1-15 AGNATEVPANSTVLS WP_005694071.1 HIN 8 87.5 VPANSTVL VPAHSTVL BNY[0.2:0.5] HLAI[HLA-B*07:02, HLA-B*08:01, HLA-B*35:01] HLAII[NONE] HU:XP_005263536.1[75.0:VPANSSLL] MB:HMPREF1071_04435[87.5:VPANTTVL] HU:XP_016855652.1[62.5:LPGHSTIL] MB:HMPREF0027_1316[100.0:VPAHSTVL] 503 YP_009725307_POL-85-99 TIYNLLKDCPAVAKH WP_005693212.1 HIN 8 87.5 LKDCPAVA LKDIPAVA BYY[1.0:1.2] HLAI[NONE] HLAII[NONE] HU:XP_016884808.1[75.0:LKNCPSVA] MB:CLOSTHATH_00491[87.5:FKDCPAVA] HU:XP_005274032.1[62.5:LRDLPGVA] MB:HMPREF9335_01044[100.0:LKDIPAVA] 504 YP_009725307_POL-245-259 LTLTRALTAESHVDT WP_005693225.1 HIN 8 87.5 LTAESHVD LAAESHVD BNY[0.3:0.4] HLAI[NONE] HLAII[NONE] HU:XP_016878370.1[62.5:VTAQSHLD] MB:HMPREF9449_03064[87.5:LAAESHVD] HU:NP_599152.2[75.0:LAAEGHLD] MB:HMPREF9450_00570[100.0:LAAESHVD] 505 YP_009725307_POL-573-587 QKLLKSIAATRGATV WP_005694358.1 HIN 8 87.5 KLLKSIAA KLLISIAA BNN[-1.7:-1.0] HLAI[NONE] HLAII[NONE] HU:NP_079389.2[62.5:KLLESVAS] MB:NO[NO] HU:NO[NO] MB:NO[NO] 506 YP_009725307_POL-585-599 ATVVIGTSKFYGGWH WP_005693457.1 HIN 8 87.5 ATVVIGTS ATVVVGTS BNN[-0.2:-0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 507 YP_009725307_POL-733-747 RNRDVDTDFVNEFYA WP_005645731.1 HIN 8 87.5 DFVNEFYA DFVVEFYA BNN[-1.2:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_011517179.1[87.5:DFLNEFYA] MB:HMPREF0621_1012[100.0:DFVNEFYA] HU:XP_011517179.1[75.0:DFLNEFYA] MB:HMPREF1119_0933[100.0:DFVVEFYA] 508 YP_009725307_POL-881-895 FHLYLQYIRKLHDEL WP_005649559.1 HIN 8 87.5 IRKLHDEL IRKLEDEL BNN[-0.1:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_060478.3[62.5:VRKLHDSV] MB:HMPREF0548_0086[87.5:IKKLHDEL] HU:NO[NO] MB:HMPREF0004_3567[100.0:IRKLEDEL] 509 YP_009725301_3CPR-61-75 KSNHNFLVQAGNVQL WP_005693713.1 HIN 8 87.5 LVQAGNVQ LVQAGNVE BNN[0.2:0.2] HLAI[NONE] HLAII[NONE] HU:NP_116251.4[62.5:LVQAGSIE] MB:HMPREF1146_1781[87.5:LVQAGNLQ] HU:NP_116251.4[75.0:LVQAGSIE] MB:HMPREF9373_0921[87.5:LVEAGNVE] 510 YP_009725301_3CPR-173-187 AGTDLEGNFYGPFVD WP_005693338.1 HIN 8 87.5 LEGNFYGP LEGGFYGP BYY[0.5:0.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1526_02201[87.5:LEGNWYGP] HU:NO[NO] MB:HMPREF1050_0337[100.0:LEGGFYGP] 511 YP_009725301_3CPR-249-263 ILGPLSAQTGIAVLD WP_005693718.1 HIN 8 87.5 LSAQTGIA LSAMTGIA BNY[-0.4:0.6] HLAI[NONE] HLAII[NONE] HU:XP_024304405.1[62.5:LDSQTGVA] MB:HMPREF4655_21484[87.5:LTAQTGIA] HU:NP_057645.1[62.5:LTALTGVA] MB:SSJG_00829[100.0:LSAMTGIA] 512 YP_009725308_HEL-145-159 FKLSYGIATVREVLS WP_005668023.1 HIN 8 87.5 ATVREVLS ATVREVLA BNN[-0.5:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_001165907.1[75.0:ATVRELLT] MB:NO[NO] HU:XP_011523224.1[75.0:ATIRKVLA] MB:HMPREF9095_0910[100.0:ATVREVLA] 513 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF WP_010869253.1 HIN 8 87.5 GPPGTGKS GPPGTGKT BYY[2.6:2.6] HLAI[NONE] HLAII[NONE] HU:XP_011516709.1[100.0:GPPGTGKS] MB:METSMIF1_03279[100.0:GPPGTGKS] HU:NP_066363.1[100.0:GPPGTGKT] MB:COLSTE_00461[100.0:GPPGTGKT] 514 YP_009725297_LP-29-43 RGFGDSVEEVLSEAR WP_005693412.1 HIN 8 87.5 VEEVLSEA VEEVLSIA BNN[-0.8:-0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF0993_01825[100.0:VEEVLSEA] HU:XP_011538638.1[75.0:VEEILSVA] MB:NO[NO] 515 YP_009724395.1_ORF7a-1-15 MKIILFLALITLATC WP_010869186.1 HIN 8 87.5 KIILFLAL KIILPLAL BNN[-1.8:-3.1] HLAI[NONE] HLAII[NONE] HU:NP_001028733.1[75.0:KLIKFLAL] MB:HMPREF9420_0033[100.0:KIILFLAL] HU:NO[NO] MB:HMPREF9428_04430[87.5:KVILPLAL] 516 YP_009725318.1_ORF7b-13-27 FLAFLLFLVLIMLII WP_005694432.1 HIN 10 80.0 LLFLVLIMLI LQFLVLPMLI BNN[-2.3:-3.8] HLAI[HLA-A*23:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*07:01, HLA-DRB1*15:01] HU:NP_001244330.1[60.0:IFLSLIMLV] MB:HMPREF9469_02761[80.0:LLFTVLIMLL] HU:XP_016856538.1[60.0:LSFLILPM] MB:HMPREF0402_02967[100.0:LQFLVLPMLI] 517 YP_009725298_NSP2-13-27 PDGYPLECIKDLLAR WP_005693687.1 HIN 10 80.0 LECIKDLLAR LECIEDLLKR BNN[-1.0:-1.2] HLAI[NONE] HLAII[NONE] HU:NP_001335658.1[70.0:LECVKHLLA] MB:HMPREF9996_01543[80.0:LECIEDLLKR] HU:NP_005253.3[70.0:ECAEDLRKR] MB:HMPREF9996_01543[100.0:LECIEDLLKR] 518 YP_009725298_NSP2-541-555 VKSREETGLLMPLKA WP_005694060.1 HIN 10 80.0 EETGLLMPLK EETGLLDNLK BNN[-0.1:-0.5] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:NP_057594.5[50.0:ETGIVMPV] MB:ENTCAN_07588[70.0:EETGLILPL] HU:NP_009293.1[60.0:DETGVMDNL] MB:HMPREF9095_1523[100.0:EETGLLDNLK] 519 YP_009725298_NSP2-277-291 EKVNINIVGDFKLNE WP_005693148.1 HIN 8 87.5 KVNINIVG KVNIAIVG BNN[-1.0:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_024301813.1[75.0:KVNINMNG] MB:HMPREF0240_00797[75.0:RVNINVVG] HU:NO[NO] MB:PROSTU_02950[100.0:KVNIAIVG] 520 YP_009725298_NSP2-513-527 IIIGGAKLKALNLGE WP_005691796.1 HIN 8 87.5 LKALNLGE LKALNLPE BNN[-0.5:-0.7] HLAI[NONE] HLAII[NONE] HU:XP_016872877.1[75.0:LESLNLGE] MB:HMPREF1117_0309[87.5:LKAVNLGE] HU:NO[NO] MB:HMPREF1053_0933[100.0:LKALNLPE] 521 YP_009724393.1_MP-157-171 GRCDIKDLPKEITVA WP_005650701.1 HIN 8 87.5 KDLPKEIT KALPKEIT BYY[1.2:0.7] HLAI[NONE] HLAII[NONE] HU:NP_056212.1[75.0:KDIPKEDT] MB:HMPREF1429_00477[100.0:KDLPKEIT] HU:NO[NO] MB:HMPREF9095_1313[100.0:KALPKEIT] 522 YP_009725299_NSP3-465-479 APYIVGDVVQEGVLT WP_005693820.1 HIN 10 80.0 VGDVVQEGVL LGYVVQEGVL BNY[-0.5:0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9095_1782[90.0:VGDVVQGGVL] HU:NO[NO] MB:NEIPOLOT_02146[100.0:LGYVVQEGVL] 523 YP_009725299_NSP3-517-531 NGYTVEEAKTVLKKC WP_005693156.1 HIN 10 80.0 VEEAKTVLKK VEEAKTAGKK BYN[1.2:0.1] HLAI[NONE] HLAII[NONE] HU:XP_016871813.1[70.0:EAKTPLKK] MB:ROSEINA2194_00824[100.0:VEEAKTVLKK] HU:NP_001337049.1[70.0:VEECKMAGK] MB:HMPREF9064_0054[90.0:VEEAKTAGQK] 524 YP_009725299_NSP3-789-803 IKPHNSHEGKTFYVL WP_010869033.1 HIN 10 80.0 NSHEGKTFYV NSHNGKVFYV BNY[-0.0:0.5] HLAI[HLA-A*01:01, HLA-B*35:01] HLAII[NONE] HU:XP_024304575.1[80.0:NSHEGKRDYV] MB:HMPREF9095_0309[80.0:NSHKGKVFYV] HU:NP_006756.2[60.0:NPHNGQVSYI] MB:HMPREF9095_0309[90.0:NSHKGKVFYV] 525 YP_009725299_NSP3-1045-1059 ITDVFYKENSYTTTI WP_010869022.1 HIN 9 88.9 FYKENSYTT FYKENSYLT BNY[0.1:0.9] HLAI[NONE] HLAII[HLA-DRB1*04:01] HU:NP_001317162.1[66.7:YKENLYGT] MB:HMPREF9709_01555[88.9:FYEENSYTT] HU:NP_001243224.1[66.7:YEENSHLT] MB:HMPREF9412_3308[77.8:FYKENGYL] 526 YP_009725299_NSP3-697-711 SYSGQSTQLGIEFLK WP_005694608.1 HIN 8 87.5 QLGIEFLK QLGKEFLK BNN[-0.4:-1.1] HLAI[NONE] HLAII[NONE] HU:XP_005273456.1[62.5:QLGVQFLR] MB:HMPREF9464_00808[75.0:QLGIEFVR] HU:NO[NO] MB:HMPREF1053_1153[100.0:QLGKEFLK] 527 YP_009725299_NSP3-1041-1055 YKGPITDVFYKENSY WP_010869022.1 HIN 8 87.5 VFYKENSY TFYKENSY BYN[0.8:0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:XP_024306920.1[75.0:TFYHENPY] MB:CLOL250_00191[87.5:TFYKENGY] 528 YP_009725299_NSP3-1113-1127 VCDNIKFADDLNQLT WP_005693714.1 HIN 8 87.5 FADDLNQL FADWLNQL BNN[-0.8:-0.0] HLAI[NONE] HLAII[NONE] HU:NP_057581.2[75.0:FADDLHNL] MB:CLOSCI_00945[87.5:FADDLNHL] HU:NP_008860.4[62.5:FADWIGRL] MB:HMPREF1119_0622[100.0:FADWLNQL] 529 YP_009725299_NSP3-1405-1419 FSKLINIIIWFLLLS WP_005694200.1 HIN 8 87.5 IIWFLLLS IIWILLLS BNN[-3.2:-3.2] HLAI[NONE] HLAII[NONE] HU:NP_004857.4[62.5:ILWFLLFT] MB:HMPREF9713_02009[87.5:IIWFTLLS] HU:NP_055741.2[62.5:MLWIILLS] MB:HMPREF9094_2015[87.5:IIWIMLLS] 530 YP_009725299_NSP3-1421-1435 CLGSLIYSTAALGVL WP_005693404.1 HIN 8 87.5 LIYSTAAL LIYSEAAL BNN[-0.6:-0.7] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_001398.2[75.0:LVYSLAAL] MB:NO[NO] HU:NO[NO] MB:HMPREF1119_1096[100.0:LIYSEAAL] 531 YP_009725299_NSP3-1745-1759 QLMCQPILLLDQALV WP_005686318.1 HIN 8 87.5 PILLLDQA PILLLDEA BNN[-1.3:-1.4] HLAI[NONE] HLAII[NONE] HU:XP_011536400.1[62.5:PVLILDEA] MB:CL2_24450[87.5:PILLLDEA] HU:XP_011536400.1[75.0:PVLILDEA] MB:NEISUBOT_03410[100.0:PILLLDEA] 532 YP_009725299_NSP3-1761-1775 DVGDSAEVAVKMFDA WP_005693467.1 HIN 8 87.5 GDSAEVAV GASAEVAV BYY[0.5:0.8] HLAI[NONE] HLAII[NONE] HU:XP_011521448.1[75.0:GDEAEVIV] MB:HMPREF1253_0743[75.0:GDAAEVAI] HU:XP_016863060.1[75.0:GAASEVAV] MB:HMPREF1146_1106[87.5:GASAEIAV] 533 YP_009725304_NSP8-157-171 QQVVDADSKIVQLSE WP_010869051.1 HIN 8 87.5 DSKIVQLS DYKIVQLS BNN[-0.8:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_001278744.1[75.0:DQKLVQLS] MB:HMPREF9371_1376[75.0:DSKIIQIS] HU:NP_001278744.1[75.0:DQKLVQLS] MB:HMPREF9199_1786[100.0:DYKIVQLS] 534 YP_009724392.1_ENV-1-15 MYSFVSEETGTLIVN WP_010869047.1 HIN 10 80.0 YSFVSEETGT YSFQSEETLT BYY[0.9:0.6] HLAI[NONE] HLAII[NONE] HU:NP_113619.3[70.0:YLFVSNKTGT] MB:HMPREF0490_01076[80.0:YSFVSDESGT] HU:NO[NO] MB:HMPREF9096_00043[90.0:YGFQSEETLT] 535 YP_009724392.1_ENV-25-39 VFLLVTLAILTALRL WP_010869043.1 HIN 10 80.0 LVTLAILTAL LISLAILTAL BNN[-1.9:-1.9] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*08:02] HU:XP_006723099.1[70.0:VTLQVLTAL] MB:HMPREF0013_01817[80.0:LITLAMLTAL] HU:NP_001353076.1[80.0:IDLAILTAL] MB:HMPREF9095_0474[100.0:LISLAILTAL] 536 YP_009724390.1_SPIKE-933-947 KIQDSLSSTASALGK WP_010869219.1 HIN 10 80.0 SLSSTASALG SLSSTASTVG BYY[0.7:1.4] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*07:01] HU:XP_006718085.1[70.0:LSSVALALG] MB:CW3_4484[80.0:NLSNTASALG] HU:NP_110420.3[70.0:STTASTVG] MB:HMPREF9095_1203[100.0:SLSSTASTVG] 537 YP_009724390.1_SPIKE-1005-1019QTYVTQQLIRAAEIR WP_005693444.1 HIN 10 80.0 TQQLIRAAEI TWQGIRAAEI BNN[0.0:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_024305467.1[70.0:QQLVEAAEI] MB:HMPREF1004_03885[80.0:TQQLIRAA] HU:XP_024305442.1[60.0:TWDGIRLGE] MB:HMPREF1053_0383[100.0:TWQGIRAAEI] 538 YP_009724390.1_SPIKE-757-771 GSFCTQLNRALTGIA WP_005694279.1 HIN 8 87.5 QLNRALTG QLNRFLTG BNN[-0.9:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_149075.2[62.5:QLNKEFTG] MB:HMPREF9623_01791[87.5:ELNRALTG] HU:NO[NO] MB:HMPREF0298_0302[100.0:QLNRFLTG] 539 YP_009724390.1_SPIKE-757-771 GSFCTQLNRALTGIA WP_005647883.1 HIN 8 87.5 NRALTGIA NRALTGKA BYN[0.9:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_078879.2[62.5:NRSVTGVA] MB:HMPREF1076_03232[87.5:NRALTGIG] HU:NO[NO] MB:HMPREF0604_01774[75.0:NRAITGKS] 540 YP_009724390.1_SPIKE-801-815 NFSQILPDPSKPSKR WP_005649475.1 HIN 8 87.5 LPDPSKPS LADPSKPS BYY[1.9:2.3] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF1053_1531[100.0:LADPSKPS] 541 YP_009724390.1_SPIKE-825-839 KVTLADAGFIKQYGD WP_005693201.1 HIN 8 87.5 ADAGFIKQ ADAGSIKQ BYN[0.9:-0.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9104_03320[87.5:ADRGFIKQ] HU:NP_940964.1[75.0:ADPGSLKQ] MB:HMPREF9095_0650[100.0:ADAGSIKQ] 542 YP_009724390.1_SPIKE-853-867 QKFNGLTVLPPLLTD WP_005693647.1 HIN 8 87.5 LTVLPPLL LTVLPPTL BNN[-0.1:-0.7] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1246_0270[87.5:LTVLPPLI] HU:NP_078813.1[75.0:LKVLPPTV] MB:HMPREF1211_05626[87.5:LSVLPPTL] 543 YP_009725300_NSP4-1-15 KIVNNWLKQLIKVTL WP_005693459.1 HIN 8 87.5 LKQLIKVT LKQSIKVT BNN[-0.3:-1.3] HLAI[NONE] HLAII[NONE] HU:XP_011532451.1[75.0:LQQLIRVT] MB:NO[NO] HU:NO[NO] MB:HMPREF1053_1257[100.0:LKQSIKVT] 544 YP_009725300_NSP4-153-167 AAECTIFKDASGKPV WP_005655572.1 HIN 8 87.5 IFKDASGK IFKRASGK BNY[0.1:0.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9945_00155[87.5:IFKDSSGK] HU:XP_005266418.1[75.0:LFKNASGK] MB:HMPREF0556_11912[87.5:IFKRAKGK] 545 YP_009725300_NSP4-321-335 LFLMSFTVLCLTPVY WP_005647842.1 HIN 8 87.5 TVLCLTPV TVLILTPV BNN[-1.5:-1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001269559.1[87.5:TVLKLTPV] MB:FSCG_00759[87.5:SVLILTPV] 546 YP_009725300_NSP4-465-479 EAACCHLAKALNDFS WP_005686427.1 HIN 8 87.5 AKALNDFS ADALNDFS BYN[0.4:-0.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9178_0962[87.5:AKSLNDFS] HU:NP_937791.2[75.0:AGSLNDFS] MB:HMPREF9095_1908[100.0:ADALNDFS] 547 YP_009725309_35EXON-481-495 GAVCRHHANEYRLYL WP_010869197.1 HIN 8 87.5 HHANEYRL HHINEYRL BNN[-0.5:0.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1077_02812[87.5:HKANEYRL] HU:NP_001129108.1[50.0:HHYNDFRF] MB:HMPREF9095_1273[100.0:HHINEYRL] 548 YP_009725310_RNASE-113-127 ETICAPLTVFFDGRV WP_005694195.1 HIN 10 80.0 PLTVFFDGRV PYTYFFDGRV BNN[-0.4:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_001353159.1[60.0:PLTVLLDG] MB:HMPREF9952_0275[80.0:PYTYFFDGRV] HU:NP_055024.2[70.0:YTYRFGGRV] MB:HMPREF1119_1842[100.0:PYTYFFDGRV] 549 YP_009725310_RNASE-65-79 PVPEVKILNNLGVDI WP_005650156.1 HIN 9 88.9 KILNNLGVD KRLNNLGVD BNN[-0.2:-0.6] HLAI[NONE] HLAII[NONE] HU:NP_000531.2[66.7:IVNNLGID] MB:HMPREF9161_00331[88.9:KILKNLGVD] HU:NO[NO] MB:HMPREF9095_1065[100.0:KRLNNLGVD] 550 YP_009725310_RNASE-65-79 PVPEVKILNNLGVDI WP_010869261.1 HIN 9 88.9 VKILNNLGV VKGLNNLGV BNN[-0.3:-1.1] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01, HLA-DRB1*04:05, HLA-DRB1*13:02, HLA-DRB1*15:01] HU:NP_783195.2[55.6:IKIMQNIGV] MB:HMPREF0864_02515[77.8:KILNNIGV] HU:XP_016883746.1[77.8:VKGLSNLG] MB:HMPREF1053_0182[100.0:VKGLNNLGV] 551 YP_009725306_NSP10-45-59 LCTHTGTGQAITVTP |YP_401662.1 EBV 8 87.5 TGQAITVT TSQAITVT BNN[0.1:0.2] HLAI[NONE] HLAII[NONE] HU:XP_024301906.1[62.5:SGQAVTVS] MB:NO[NO] HU:XP_024307184.1[62.5:TAQSITIT] MB:NO[NO] 552 YP_009725307_POL-21-35 PCGTGTSTDVVYRAF |YP_401694.1 EBV 8 87.5 GTGTSTDV GTGTSTGV BYY[1.5:1.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1011_02848[100.0:GTGTSTDV] HU:NP_001609.2[75.0:GTGISSGV] MB:HMPREF1078_00143[100.0:GTGTSTGV] 553 YP_009725307_POL-257-271 VDTDLTKPYIKWDLL |YP_401667.1 EBV 8 87.5 TKPYIKWD TVPYIKWD BNY[-0.1:1.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1152_0715[75.0:TRPYIAWD] HU:NO[NO] MB:HMPREF9199_1338[75.0:TAPYIHWD] 554 YP_009725302_NSP6-229-243 CLLNRYFRLTLGVYD |YP_401712.1 EBV 8 87.5 FRLTLGVY FRLTGGVY BNN[-0.3:-1.4] HLAI[NONE] HLAII[NONE] HU:NP_004664.1[62.5:YRLRLGTY] MB:HMPREF9628_00728[75.0:FRVTLGIY] HU:NO[NO] MB:HMPREF1019_01803[75.0:FRLKGGIY] 555 YP_009725308_HEL-241-255 VPQEHYVRITGLYPT |YP_401712.1 EBV 8 87.5 VRITGLYP VRITGLIP BNN[-0.8:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_024306297.1[75.0:LRISGLYP] MB:HMPREF1109_0716[87.5:VRITGYYP] HU:XP_011537928.1[75.0:VTITGLLP] MB:CLOSTHATH_00931[87.5:VRIAGLIP] 556 YP_009725299_NSP3-1289-1303 IKKPNELSRVLGLKT |YP_401644.1 EBV 8 87.5 ELSRVLGL ELSPVLGL BNN[-0.4:-1.1] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF1084_02720[87.5:ELSRILGL] HU:XP_016873780.1[87.5:ELSPVLNL] MB:HMPREF1065_00029[87.5:DLSPVLGL] 557 YP_009724397.2_NP-301-315 WPQIAQFAPSASAFF |YP_401663.1 EBV 8 87.5 APSASAFF APSASAPF BYY[1.4:0.4] HLAI[HLA-B*07:02, HLA-B*35:01] HLAII[NONE] HU:NO[NO] MB:BACOVA_02710[87.5:APSASKFF] HU:XP_024310112.1[75.0:APSSSTPF] MB:HMPREF0276_0724[87.5:APAASAPF] 558 YP_009725310_RNASE-249-263 HLLIGLAKRFKESPF |YP_401688.1 EBV 10 80.0 LAKRFKESPF LKKRFKESYF BNN[-0.3:0.1] HLAI[NONE] HLAII[NONE] HU:NP_001293013.1[60.0:AEKFKESP] MB:HMPREF6485_2330[80.0:LSKRFGESPF] HU:XP_016865197.1[70.0:LANRFKESY] MB:HMPREF1061_03349[60.0:RKFKESYF] 559 YP_009725310_RNASE-293-307 SVIDLLLDDFVEIIK |YP_401687.1 EBV 10 80.0 DLLLDDFVEI DLLLDASVEI BNN[-0.8:-1.1] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*03:01, HLA-DRB3*01:01] HU:XP_016864075.1[70.0:IALDDFVEI] MB:EUBVEN_02711[80.0:DLLFDDFVE] HU:XP_011534895.1[70.0:LLLDASLE] MB:HMPREF9455_02540[80.0:DLLLDVPVEI] 560 YP_009725299_NSP3-737-751 NLKTLLSLREVRTIK NP_040145.1 HZV 8 87.5 NLKTLLSL NLKTLLKL BNN[-1.5:-1.4] HLAI[HLA-B*08:01] HLAII[NONE] HU:NP_001267.2[87.5:NLKTLLSV] MB:NO[NO] HU:XP_011508322.1[87.5:NIKTLLKL] MB:HMPREF9436_00806[87.5:NIKTLLKL] 561 YP_009725304_NSP8-69-83 QMYKQARSEDKRAKV NP_040156.1 HZV 8 87.5 SEDKRAKV SEDKLAKV BNY[0.3:1.0] HLAI[NONE] HLAII[NONE] HU:NP_001013765.2[75.0:SEDERAKM] MB:BIFPSEUDO_02365[87.5:SEDKRARV] HU:NP_004374.1[75.0:SEDNVAKV] MB:HMPREF9294_0284[87.5:AEDKLAKV] 562 YP_009724390.1_SPIKE-989-1003 AEVQIDRLITGRLQS NP_040162.2 HZV 8 87.5 LITGRLQS LITGHLQS BNN[-0.5:-0.4] HLAI[NONE] HLAII[NONE] HU:NP_001167455.1[75.0:MTTGRLQS] MB:NO[NO] HU:NO[NO] MB:HMPREF1078_00982[87.5:LINGHLQS] 563 YP_009724397.2_NP-213-227 NGGDAALALLLLDRL NP_040149.1 HZV 10 80.0 GDAALALLLL GYADLALLLL BNN[-1.7:-1.6] HLAI[HLA-B*35:01] HLAII[NONE] HU:NP_001193872.1[80.0:GSAALVLLLL] MB:HMPREF1075_02957[80.0:GDAALALL] HU:NP_003651.1[70.0:YSDLALLL] MB:ACTODO_01066[70.0:GYSDLALLI] 564 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF YP_009163893.1 PPV 10 80.0 GPPGTGKSHF GPPDTGKSLF BYY[1.6:1.9] HLAI[NONE] HLAII[NONE] HU:XP_011540546.1[80.0:GPPGTGKTLF] MB:HMPREF9402_1702[90.0:GPPGTGKSH] HU:XP_011540546.1[80.0:GPPGTGKTLF] MB:PORUE0001_0448[80.0:GPPGTGKTLF] 565 YP_009725297_LP-9-23 NEKTHVQLSLPVLQV YP_009163893.1 PPV 10 80.0 VQLSLPVLQV VQLSLPPLLV BNN[-0.7:-1.0] HLAI[HLA-A*02:01] HLAII[HLA-DRB1*01:01, HLA-DRB1*03:01, HLA-DRB1*09:01] HU:NP_001362722.1[80.0:QLLLPVLQV] MB:HMPREF1061_01329[80.0:VQLSTPVLQ] HU:NP_000618.3[70.0:FSLPPLLV] MB:HMPREF1308_02003[80.0:VQVSLPPLFV] 566 YP_009725299_NSP3-1805-1819 NVSLDNVLSTFISAA NP_054711.1 MUV 8 87.5 LSTFISAA LSTSISAA BYN[0.8:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_016865149.1[87.5:LSTFFSAA] MB:CBFG_03530[87.5:ISTFISAA] HU:XP_005264295.1[75.0:LSTSISVS] MB:NO[NO] 567 YP_009724390.1_SPIKE-269-283 YLQPRTFLLKYNENG NP_054707.1 MUV 8 87.5 LLKYNENG LLRYNENG BNN[-0.0:0.1] HLAI[NONE] HLAII[NONE] HU:NP_002652.2[75.0:LLKYNQKG] MB:CIT292_08500[87.5:LLKYDENG] HU:NO[NO] MB:RBR_13830[87.5:LARYNENG] 568 YP_009725298_NSP2-145-159 HCGETSWQTGDFVKA YP_009137214.1 HSV2 8 87.5 ETSWQTGD EPSWQTGD BYY[1.6:1.3] HLAI[NONE] HLAII[NONE] HU:NP_863654.1[62.5:ETKWRNGD] MB:HMPREF9477_00994[87.5:ETSWKTGD] HU:NO[NO] MB:CLOSTMETH_03614[75.0:EPAWPTGD] 569 YP_009725308_HEL-277-291 YSTLQGPPGTGKSHF YP_009505608.1 HRVA 10 80.0 LQGPPGTGKS IHGPPGTGKS BYY[2.1:2.2] HLAI[NONE] HLAII[NONE] HU:NP_066363.1[80.0:IQGPPGTGKT] MB:HMPREF1068_02855[100.0:LQGPPGTGKS] HU:XP_011516708.1[100.0:IHGPPGTGKS] MB:HMPREF1082_02112[90.0:LHGPPGTGKS] 570 YP_009725303_NSP7-9-23 TSVVLLSVLQQLRVE YP_081506.1 CMV 8 87.5 LLSVLQQL LLSALQQL BNN[-1.2:-1.6] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:NO[NO] 571 YP_009725302_NSP6-65-79 AFLCLFLLPSLATVA WP_003401224.1 BCG 8 87.5 LLPSLATV LLPNLATV BNN[-0.6:-0.6] HLAI[HLA-A*02:01] HLAII[NONE] HU:NP_003449.2[87.5:LLPSTATV] MB:RSAG_01868[75.0:LMPSLATI] HU:NP_060098.3[75.0:LMPNGATV] MB:HMPREF0973_02386[75.0:ILPNLATI] 572 YP_009725308_HEL-37-51 TSHKLVLSVNPYVCN WP_003909568.1 BCG 10 80.0 HKLVLSVNPY HKLVLSRGPY BNN[-0.4:-0.8] HLAI[HLA-A*03:01] HLAII[NONE] HU:XP_016869105.1[60.0:HQLILSVDPW] MB:HMPREF9952_0206[70.0:HKFVLSVDP] HU:XP_005257702.1[60.0:QKTSMSRGPY] MB:HMPREF5505_0659[80.0:HKLVTSRGP] 573 YP_009725308_HEL-141-155 TEETFKLSYGIATVR WP_003409680.1 BCG 8 87.5 FKLSYGIA FKPSYGIA BYN[0.5:-0.8] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:XP_016865461.1[62.5:FTPASGIA] MB:HMPREF0591_0947[100.0:FKPSYGIA] 574 YP_009725299_NSP3-1805-1819 NVSLDNVLSTFISAA WP_003900676.1 BCG 8 87.5 LSTFISAA LSTVISAA BNN[-0.6:-0.8] HLAI[NONE] HLAII[NONE] HU:XP_016865149.1[87.5:LSTFFSAA] MB:CBFG_03530[87.5:ISTFISAA] HU:XP_016861618.1[75.0:VKTVISAA] MB:NO[NO] 575 YP_009724397.2_NP-401-415 DDFSKQLQQSMSSAD WP_003410228.1 BCG 8 87.5 QQSMSSAD QQSMSTAD BYY[0.9:1.0] HLAI[NONE] HLAII[NONE] HU:NP_037450.2[87.5:QLSMSSAD] MB:NO[NO] HU:XP_024303709.1[75.0:QQSMQTSD] MB:HMPREF9402_2455[75.0:EQAMSTAD] 576 YP_009725306_NSP10-1-15 AGNATEVPANSTVLS WP_014318982.1 CDI 8 87.5 ATEVPANS ATEVNANS BYY[0.9:1.3] HLAI[NONE] HLAII[NONE] HU:NP_001257296.1[75.0:AGELPANS] MB:HMPREF0518_1021[87.5:ATEVPENS] HU:XP_016882097.1[75.0:ATELGANS] MB:NO[NO] 577 YP_009725299_NSP3-1757-1771 ALVSDVGDSAEVAVK WP_010935426.1 CDI 8 87.5 GDSAEVAV GDSAEVVV BYY[0.4:0.8] HLAI[NONE] HLAII[NONE] HU:XP_011521448.1[75.0:GDEAEVIV] MB:HMPREF1253_0743[75.0:GDAAEVAI] HU:XP_011521448.1[75.0:GDEAEVIV] MB:ROSINTL182_06325[75.0:GDSAEIIV] 578 YP_009725302_NSP6-65-79 AFLCLFLLPSLATVA WP_005015014.1 BPE 9 88.9 LLPSLATVA LLPSLVTVA BNN[-0.9:-0.5] HLAI[NONE] HLAII[HLA-DRB1*01:01, HLA-DRB1*04:01] HU:XP_024303860.1[66.7:FLPSLQTIA] MB:HMPREF0240_00848[88.9:LPSLATVA] HU:NP_003931.2[66.7:LPALVTIA] MB:CLOSPI_00354[77.8:LLPTMVTVA] 579 YP_009725308_HEL-241-255 VPQEHYVRITGLYPT WP_010930723.1 BPE 8 87.5 VRITGLYP VRITGLGP BNN[-0.1:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_024306297.1[75.0:LRISGLYP] MB:HMPREF1109_0716[87.5:VRITGYYP] HU:NO[NO] MB:HMPREF9696_02128[87.5:VRMTGLGP] 580 YP_009725304_NSP8-41-55 SLNVAKSEFDRDAAM WP_010931585.1 BPE 10 80.0 VAKSEFDRDA VAYSELDRDA BYY[0.4:0.7] HLAI[NONE] HLAII[NONE] HU:NP_001356843.1[70.0:VAQTEFDRQA] MB:HMPREF9538_04084[70.0:VARVEFDREA] HU:XP_011531007.1[60.0:SYDELKRDA] MB:HMPREF1076_04008[70.0:LAYSELNRNA] 581 YP_009725307_POL-361-375 LHSSRLSFKELLVYA WP_011099228 CTE 9 88.9 SRLSFKELL SQLSFKELL BNN[-0.9:-1.0] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9007_03355[77.8:SRLQFKEVL] HU:NO[NO] MB:BSIG_5926[77.8:SQLSYKEL] 582 YP_009725307_POL-137-151 GNCDTLKEILVTYNC WP_035110712 CTE 8 87.5 LKEILVTY LKEILVNY BNN[-1.4:-1.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NP_001161693.1[87.5:LKEILQNY] MB:CLOSPO_00917[100.0:LKEILVNY] 583 YP_009725304_NSP8-97-111 KLDNDALNNIINNAR WP_078688078 CTE 8 87.5 ALNNIINN ALNNILNN BNN[-0.8:-0.7] HLAI[NONE] HLAII[NONE] HU:NP_005468.1[50.0:SINNMVNN] MB:HMPREF9264_1205[75.0:ALNNLLNN] HU:NP_001309223.1[75.0:AFNNILSN] MB:HMPREF9264_1205[87.5:ALNNLLNN] 584 YP_009725302_NSP6-261-275 PPKNSIDAFKLNIKL WP_000143443.1 SPN 8 87.5 AFKLNIKL AKKLNIKL BNN[-0.9:-1.4] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:NO[NO] HU:NO[NO] MB:HMPREF9475_02519[100.0:AKKLNIKL] 585 YP_009725297_LP-57-71 EKGVLPQLEQPYVFI WP_000767212.1 SPN 8 87.5 LEQPYVFI LEFPYVFI BNN[-1.3:-0.5] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9260_01685[87.5:LENPYVFI] HU:XP_024307270.1[62.5:LVFPFIFI] MB:HMPREF9188_01066[100.0:LEFPYVFI] 586 YP_009725308_HEL-425-439 VCRLMKTIGPDMFLG WP_002225226.1 NSM 11 81.8 VCRLMKTIGPD VLRLMKTIGSD BNN[-0.8:-0.5] HLAI[NONE] HLAII[NONE] HU:XP_011540683.1[63.6:LCRLLTTIGKD] MB:NEILACOT_03416[81.8:VLRLMKTIGSD] HU:XP_005257919.1[54.5:LMETVGSD] MB:HMPREF0602_0992[100.0:VLRLMKTIGSD] 587 YP_009725310_RNASE-133-147 LFRNARNGVLITEGS WP_010930155.1 BPE 11 80.0 RNARNGVLITE RNARNGWLFTE BNN[-0.1:-0.1] HLAI[NONE] HLAII[NONE] HU:NP_056277.2[63.6:NARNGVALT] MB:HMPREF1154_0117[72.7:RNARNGMLFT] HU:NO[NO] MB:HMPREF0604_00235[90.9:RNARNGWLFT] 588 YP_009725310_RNASE-133-147 LFRNARNGVLITEGS WP_002225464.1 NSM 10 80.0 RNARNGVLIT RNARNGWLFT BNN[-0.1:-0.2] HLAI[NONE] HLAII[NONE] HU:NP_056277.2[70.0:NARNGVALT] MB:HMPREF1154_0117[80.0:RNARNGMLFT] HU:NO[NO] MB:HMPREF0604_00235[100.0:RNARNGWLFT] 589 YP_009724391.1_ORF3a-249-263 IDGSSGVVNPVMEPI WP_010869064.1 HIN 8 87.5 VNPVMEPI VNPVNEPI BYY[1.1:0.7] HLAI[NONE] HLAII[NONE] HU:XP_016855951.1[62.5:VNPLLEPV] MB:HMPREF0299_6526[75.0:VNPVLEPL] HU:NO[NO] MB:HMPREF9096_00214[100.0:VNPVNEPI] 590 YP_009724396.1_ORF8-65-79 AGSKSPIQYIDIGNY WP_010868940.1 HIN 8 87.5 IQYIDIGN IQYIWIGN BNN[-1.3:-0.5] HLAI[NONE] HLAII[NONE] HU:NP_079040.2[62.5:VKYIDLGN] MB:HMPREF9441_01831[75.0:LQYIEIGN] HU:XP_024306714.1[50.0:VQFLWVGN] MB:HMPREF1118_1805[100.0:IQYIWIGN] 591 YP_009724390.1_SPIKE-777-791 NTQEVFAQVKQIYKT WP_010930923.1 BPE 8 87.5 TQEVFAQV TQEVVAQV BNN[-0.1:-0.3] HLAI[NONE] HLAII[NONE] HU:XP_016879421.1[75.0:SEEVFAQV] MB:HMPREF9447_04733[87.5:TQEVFADV] HU:NP_653173.1[62.5:TREVIAQL] MB:NO[NO] 592 YP_009724396.1_ORF8-85-99 PFTINCQEPKLGSLV WP_011098678 CTE 8 87.5 QEPKLGSL QEPKKGSL BYY[1.6:0.7] HLAI[NONE] HLAII[NONE] HU:XP_011544263.1[62.5:REPRLGEL] MB:HMPREF0731_3359[75.0:QQPQLGSL] HU:NO[NO] MB:BRYFOR_07389[87.5:QEPPKGSL] 593 YP_009725298_NSP2-533-547 SKGLYRKCVKSREET WP_002225315.1 NSM 8 87.5 KCVKSREE KVVKSREE BYY[0.4:0.4] HLAI[NONE] HLAII[NONE] HU:XP_016863819.1[75.0:KCVKSRKD] MB:HMPREF9306_01370[75.0:KCLKSRQE] HU:XP_024301900.1[62.5:QTIKSREE] MB:HMPREF1214_03587[87.5:EVVKSREE] 594 YP_009725299_NSP3-1493-1507 ISSFKWDLTAFGLVA YP_009137182.1 HSV2 8 87.5 LTAFGLVA LTAAGLVA BNN[-0.5:-1.2] HLAI[NONE] HLAII[NONE] HU:NO[NO] MB:HMPREF9958_0925[87.5:LSAFGLVA] HU:NP_000194.2[75.0:LTAMGLLA] MB:HMPREF0531_11919[100.0:LTAAGLVA] 595 YP_009725309_35EXON-1-15 AENVTGLFKDCSKVI WP_014319275.1 CDI 8 87.5 AENVTGLF AENVTGFF BNN[-0.0:-0.1] HLAI[HLA-B*40:01, HLA-B*44:02, HLA-B*44:03] HLAII[NONE] HU:NO[NO] MB:HMPREF0291_10966[87.5:AENVTGFF] HU:NO[NO] MB:HMPREF0291_10966[100.0:AENVTGFF]

* B cell reactivity. In this study peptides were considered cros-reactive epitopes when HIT peptides scores were ≥ 0.4 ** CoV-2 and Hit peptides are both predicted to bind to the listed HLA molecules