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Centor Criteria in Children in a Paediatric Emergency Department: for What It Is Worth

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Centor Criteria in Children in a Paediatric Emergency Department: for What It Is Worth Open Access Research BMJ Open: first published as 10.1136/bmjopen-2013-002712 on 22 April 2013. Downloaded from Centor criteria in children in a paediatric emergency department: for what it is worth Inge Roggen,1,2 Gerlant van Berlaer,1,2 Frans Gordts,3 Denis Pierard,4 Ives Hubloue1,2 To cite: Roggen I, van ABSTRACT et al ARTICLE SUMMARY Berlaer G, Gordts F, . Introduction: Centor criteria (fever >38.5°C, swollen, Centor criteria in children tender anterior cervical lymph nodes, tonsillar exudate in a paediatric emergency Article focus and absence of cough) are an algorithm to assess the ▪ To evaluate the correlation between Centor cri- department: for what it is β Streptococcus worth. BMJ Open 2013;3: probability of group A haemolytic teria and presence of GABHS in children with e002712. doi:10.1136/ (GABHS) as the origin of sore throat, developed for sore throat admitted to our emergency depart- bmjopen-2013-002712 adults. We wanted to evaluate the correlation between ment, in order to evaluate the value of this pre- Centor criteria and presence of GABHS in children with diction rule. sore throat admitted to our paediatric emergency ▸ Prepublication history for department (PED). Key messages this paper are available ▪ online. To view these files Design: Retrospective cohort study. Results confirm the ineffectiveness of Centor cri- please visit the journal online Setting: The emergency department of a large tertiary teria as a predicting factor for finding GABHS in (http://dx.doi.org/10.1136/ university hospital in Brussels, with over 20 000 yearly a throat swab culture in children. bmjopen-2013-002712). visits for children below age 16. Strengths and limitations of this study Participants: All medical records (from 2008 to ▪ Received 11 February 2013 The strength of this study is the large number of Revised 17 March 2013 2010) of children between ages 2 and 16, who were children included. The major limitation is the fact Accepted 18 March 2013 diagnosed with pharyngitis, tonsillitis or sore throat that not all children received a throat swab, thus and having a throat swab culture for GABHS. Children introducing a selection bias. This final article is available with underlying chronic respiratory, cardiac, for use under the terms of haematological or immunological diseases and children http://bmjopen.bmj.com/ the Creative Commons who had already received antibiotics (AB) prior to the When all four criteria (fever >38.5°C, swollen, Attribution Non-Commercial PED consult were excluded. Only records with a full tender anterior cervical lymph nodes, tonsillar 2.0 Licence; see disease history were selected. Out of a total 2118 visits http://bmjopen.bmj.com exudate and absence of cough) are present, the for sore throats, 441 met our criteria. The children probability of GABHS is just above 50%. When were divided into two age groups, 2–5 and 5–16 years. two or less criteria are present, the probability is Results: The prevalence of GABHS was higher in the below 15%. Hence, Centor criteria are often older children compared to the preschoolers (38.7 vs used as a tool to assess the absence of GABHS, 27.6; p=0.01), and the overall prevalence was 32%. 2–4 There was no significant difference in the prevalence of rather than its presence. It should also be on October 2, 2021 by guest. Protected copyright. fi 1Department of Emergency GABHS for all different Centor scores within an age noted that these criteria were speci cally devel- 1 et al5 6 Medicine, UZ Brussel, Vrije group. Likelihood ratios (LR) demonstrate that none of oped for adults. More recently, McIsaac Universiteit Brussel, Jette, the individual symptoms or a Centor score of ≥3 developed modified criteria, which add the age Belgium seems to be effective in ruling in or ruling out GABHS. of the patient (+1 if age 3–14, 0 if age 15–44 2 Research Group on Pooled LR (CI) for Centor ≥3 was 0.67 (CI 0.50 to and -1 if age ≥45), taking into account the fact Emergency and Disaster 0.90) for the preschoolers and 1.37 (CI 1.04 to 1.79) Medicine Brussels, UZ that GABHS is more prevalent in the age group for the older children. – 27–10 Brussel, Vrije Universiteit of 5 15 years. Still, several studies have Brussel, Jette, Belgium Conclusions: Our results confirm the ineffectiveness shown that neither signs and symptoms, nor 3Department of of Centor criteria as a predicting factor for finding signs and symptoms combined as prediction GABHS in a throat swab culture in children. Otolaryngology, UZ Brussel, rules, were reliable to distinguish between Vrije Universiteit Brussel, 11–16 Jette, Belgium GABHS and non-GABHS pharyngitis. 4Department of Microbiology The administration of antibiotics used to and Infection Control, UZ be indicated, based on the incidence of non- Brussel, Vrije Universiteit INTRODUCTION suppurative complications (post-streptococcal Brussel, Jette, Belgium In 1981, Centor et al1 developed four criteria to glomerulonephritis and reactive arthritis), Correspondence to predict the probability of the presence of after streptococcal pharyngitis, but a large 17 Dr Inge Roggen; Streptococcus pyogenes or group A β haemolytic Cochrane review by Del Mar et al states that [email protected] Streptococcus (GABHS) in a throat swab culture. the use of antibiotics (AB) in otherwise Roggen I, van Berlaer G, Gordts F, et al. BMJ Open 2013;3:e002712. doi:10.1136/bmjopen-2013-002712 1 Centor criteria in children BMJ Open: first published as 10.1136/bmjopen-2013-002712 on 22 April 2013. Downloaded from healthy individuals is no longer indicated, as not only swab for GABHS culture with the following ICD-9 codes has the incidence of non-suppurative complications dis- infectious mononucleosis (075), nasopharyngitis (460), appeared in the developed world since the late 1960s pharyngitis (462), tonsillitis (463) and sore throat but also antibiotics will not shorten disease duration or (784.1) were included for analysis. Children with under- symptoms.17 18 With the possibility of the adverse effects lying chronic respiratory, cardiac, haematological or of AB, the benefit to risk ratio no longer favours admin- immunological diseases and children who had already istering AB to otherwise healthy individuals with strepto- received AB prior to the PED consult were excluded. coccal pharyngitis. Only records with a full disease history were selected (figure 1). We divided patients into 2 groups, preschoolers (≥2 OBJECTIVES and <5 years) and kids (≥5 and <16 years), as the preva- In our paediatric emergency department (PED), physi- lence of GABHS is different in both groups. cians are taught to follow the guidelines of the Belgian Statistical analysis was performed using MedCalc Antibiotic Policy Coordination Committee (BAPCOC). V.12.3.0 (MedCalc Software bvba, Mariakerke, Belgium). BAPCOC guidelines are based on the review by Del Mar All data are presented as mean±standard deviation or as 17 et al. And yet we found that, in our PED, in 2009 and median (range), when not normally distributed. 2010, of 1345 otherwise healthy children, 35% were pre- D’Agostino-Pearson K2 test was used for assessing nor- scribed AB (unpublished data). For general practitioners mality of data. Spearman’s rho test was used to calculate in Flanders, the prescription rate is as high as 50%, even rank correlation coefficients. without knowing whether or not the pharyngitis was caused by GABHS.2 As many clinicians tend to rely on signs and symptoms, rather than on a strep test or throat RESULTS swab culture, we wanted to evaluate the correlation Out of all 2118 PED visits for sore throat, 441 (230 boys between Centor criteria and presence of GABHS in chil- and 211 girls) met our criteria (graph 1). Median age dren with sore throat admitted to our PED, in order to (range) was 5 years (2–15.9). It was 3.3 years (2–4.9) in evaluate the value of this prediction rule. the preschoolers (n=286) and 7.6 (5–15.9) in the kids (n=155). Throat swab culture for GABHS was positive for 32% of the patients. In kids, the prevalence of PATIENTS AND METHODS GABHS was higher compared to the preschoolers (38.7 This is a retrospective cohort study that was approved by vs 27.6; p=0.01). Median age and gender distribution the local ethics committee of UZ Brussel and took place was not statistically significant between the included and at the emergency department at UZ Brussel, a large ter- excluded children. http://bmjopen.bmj.com/ tiary university hospital in Brussels, with over 60 000 The mean Centor score was similar between preschoo- yearly visits, of which one in three are children below lers and kids (2.6±0.9 vs 2.6±0.9; p=0.8). The mean age 16. Children are seen at the paediatrics section, by (95% CI) presence of GABHS in our preschoolers was paediatric residents and emergency medicine residents, 45% (CI 28% to 63%) with <2 Centor criteria present, under full supervision of a board-certified paediatrician. 33% (CI 24% to 43%) with 2, 23% (CI 15% to 31%) We analysed all medical records of children aged with 3 and 13% (CI 3% to 24%) with 4 criteria, respect- between 2 and 16 years who were admitted to our PED ively, present. In kids, this was 35% (CI 10% to 61%) between 1 January 2008 and 31 December 2010. All our when ≤1, 31% (CI 17% to 44%) when 2, 43% (CI 31% on October 2, 2021 by guest. Protected copyright. records are digitalised and all diagnoses in our records to 55%) when 3 and 45% (CI 21% to 69%) when 4 cri- are registered according to the International Statistical teria were present (table 1).
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