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2 ‘2’ 1: Orthodontic IN BRIEF • Raises awareness of an integrated treatment approach to replace missing PRACTICE repositioning of lateral maxillary central incisors with lateral incisors. • Presents the indications, advantages and disadvantages for this treatment incisors into central incisors approach. • Discusses important orthodontic R. J. McDowall,1 R. Yar2 and D. T. Waring3 and restorative considerations when camouflaging lateral incisors to mimic central incisors. VERIFIABLE CPD PAPER

The clinical problem of how best to manage an anterior space resulting from a missing central incisor will only be encoun- tered rarely. The goal should be to deliver treatment results that are indistinguishable from normal appearance. This article describes one treatment approach – orthodontic space closure with substitution of the maxillary central incisor by the lateral incisor. Treatment indications, orthodontic and restorative considerations, advantages and disadvantages, as well as the evidence base relating to this treatment modality will be presented and supported by two clinical case examples.

INTRODUCTION by restorative modification to simulate a Table 1 General treatment planning considerations for the management of a A central incisor may be missing follow- central incisor.2 The last treatment option missing maxillary central incisor ing traumatic avulsion, developmental consists of total orthodontic space clo- Treatment planning considerations absence or an enforced extraction due to sure with substitution of the lateral inci- being malformed, grossly displaced, anky- sor for the central incisor in the final Patient wishes losed, severely fractured or as a result of occlusal scheme.3 Each of these treatment Need for orthodontic treatment in general local pathology. The clinical management approaches has its advantages and disad- Patient age of the resultant anterior edentulous space, vantages, but the choice of the appropriate to produce both a functional and aesthetic solution very much depends on the specific Number of missing teeth result, can be a significant challenge. characteristics of each individual situation. Type of malocclusion This is particularly the case for young Important treatment planning considera- Space considerations patients, where there is a need to preserve tions when deciding how best to manage a Soft tissue profile alveolar bone and gingival architecture missing maxillary central incisor are listed during the continuous growth of the in Table 1. Lateral incisor width and root length dentofacial complex. Canine shape and colour Essentially, there are three treatment TOTAL ORTHODONTIC SPACE CLOSURE Likely success rate approaches for a young person with a Relative cost:risk/benefit ratio missing maxillary central incisor and This article will specifically focus on concomitant malocclusion.1 The first orthodontic space closure with substitu- involves reopening and/or maintaining tion of the maxillary central incisor by the Table 2 Clinical indications for choosing orthodontic space closure and substitution the space throughout childhood allowing lateral incisor. The clinical indications for of the missing maxillary central incisor by for a definitive prosthetic replacement in choosing this treatment approach are listed the lateral incisor adulthood. The second approach includes in Table 2. This method is particularly Clinical indications for space closure autotransplantation followed favoured when there is concomitant dental General need and desire for orthodontic treatment crowding or an increased overjet, whereby the anterior edentulous space can be use- Young person Absence of gingival show on smiling 1FTTA in Orthodontics, Dorset County Hospital, Wil- fully utilised to correct the malocclusion liams Avenue, Dorchester, DT1 2JY; 2Specialist Registrar avoiding the need to extract an additional Crowded maxillary arch in Restorative Dentistry, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester, within the affected quadrant. Increased overjet M15 6FH; 3*Consultant Orthodontist, University Dental Undertaking orthodontic space closure Hospital of Manchester, Higher Cambridge Street, Full profile Manchester, M15 6FH in the management of a missing maxil- *Correspondence to: Mr David Waring lary central incisor dictates that the lateral Large lateral incisor with good root length Email: [email protected] incisor takes over the aesthetic and func- Small white canine Refereed Paper tional role of the central incisor, the canine Healthy adjacent teeth Accepted 10 January 2012 assumes the role of the lateral incisor and DOI: 10.1038/sj.bdj.2012.368 Access to restorative support ©British Dental Journal 2012; 212: 417-423 the first premolar the role of the canine.

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Labio-palatal tooth positioning RESTORATIVE CONSIDERATIONS Such positional alterations will necessitate specific orthodontic and restorative inter- The type of restoration to be placed on proportions ventions to facilitate camouflaging the the lateral incisor will ultimately deter- involved teeth. Camouflaging canines and mine its labio-palatal position. If a direct The substituted lateral incisor needs to be to resemble lateral incisors and composite restoration or porcelain veneer built up to the correct crown size and shape canines respectively has widely been dis- is to be utilised the lateral incisor should to mimic a central incisor. Guidance on the cussed in the literature.4 Therefore, we will be positioned palatally, close to contact- exact dimensions required can be gauged concentrate on the orthodontic and restor- ing the mandibular incisors. If a porcelain from the adjacent intact central incisor. ative camouflage considerations relating crown is chosen the tooth should be posi- However, if both central incisors are miss- to lateral incisors and their substitution for tioned on the centre of the ridge, leaving ing the use of the golden proportion, with missing maxillary central incisors. 0.5‑0.75 mm of overjet and allowing for a relative width ratio of 1.616:1.0:0.618 minimal tooth preparation on the palatal for the central incisor, lateral incisor and ORTHODONTIC CONSIDERATIONS aspect.8 It has also been proposed that the canine respectively,10 and the 80% rule, Diagnostic wax setup substituted lateral incisor should not actu- whereby the ideal maxillary central inci- ally contact the mandibular incisors, there- sor should be approximately 80% width A diagnostic wax setup of the proposed fore theoretically reducing the functional compared with height,11 can be helpful. tooth movements and the necessary modi- load on the tooth and avoiding unwanted However, many smiles exhibit dispropor- fications to camouflage the teeth is a use- jiggling forces.9 tionality, so these measurements should ful adjunct to facilitate treatment planning, not be taken as an absolute rule. patient consent and construction of a vacu- Tooth angulation formed matrix to aid restorative treatment.1,5 The substituted lateral incisor should Type of restoration ideally be positioned more parallel than Porcelain restorations, in particular ultra- Vertical tooth positioning normal or even slightly upright. This will thin enamel-bonded porcelain veneers, The orthodontist should disregard the improve the mesial emergence profile and have proved to be both aesthetic and incisal edge of the substituted lateral inci- ensure that a favourable contact point can extremely durable restorations and rep- sor as a guide for final tooth positioning be created with the adjacent central inci- resent the preferred treatment option for and concentrate on correctly positioning sor. Too much mesial crown angulation adults when camouflaging lateral incisors the gingival margin. As such, the lateral can result in a large gingival embrasure as centrals.12 An ultra-thin porcelain veneer incisor must be intruded significantly and a black negative space that compro- can also be placed directly onto a lateral so that its gingival margin matches the mises optimum aesthetics.5,9 incisor of a young patient, as the risks of adjacent central incisor and the ipsilat- perforation and exposure of gingi- eral first premolar, camouflaging as the Appliance individualisation val crown margins during canine.1 Intrusion also provides further It is recommended that the central inci- are not contra-indications for a minimally intra-occlusal space to build up the tooth sor bracket, in the pre-adjusted edgewise invasive preparation with enamel-bonded to the correct vertical height and contour appliance, is placed on the substituted porcelain.4 However, composite resin to mimic a central incisor.6 lateral incisor. The wide central incisor build-up of the substituted lateral incisor bracket will more efficiently maintain the is still considered the treatment of choice Mesio-distal tooth positioning desired mesio-distal angulation of the lat- in young patients; because it is reversible, The cervical portion of the lateral incisor eral incisor and will also ensure that the non-destructive in nature, relatively inex- is narrower mesio-distally than the cen- inclination of this tooth matches the adja- pensive and allows for future incremental tral. The mesial and distal margins must cent central incisor. addition and removal of material as the therefore be over contoured otherwise the patient continues to mature.5,7,13 In addi- restoration will be triangular in shape and Retention tion, the physical and optical character- not match the adjacent central incisor. In There is a high risk of anterior space re- istics of today’s resin materials combined particular, the emergence profile of a max- opening following this treatment approach with their improved handling properties illary central incisor is generally flat on and therefore long term, preferably fixed, and their ability to be polished to a natu- the mesial surface. Therefore, in order to orthodontic retention is necessary. If both ral luster enable the clinician to deliver a maximise aesthetics, the substituted lateral central incisors are missing, consideration highly aesthetic and predictable restora- incisor should be moved as close to the should be given to linking the restorations tion. The use of a vacuformed matrix when midline so that the artificial crown can be on the lateral incisors, either as linked building up the lateral incisor is preferred made wider on the distal aspect rather than integral restorations or by bonding a to the ‘free hand’ intra-oral layering tech- the mesial aspect.1,3 Movement of the lat- multi-strand orthodontic wire across their nique as it reduces chair time requirements eral incisor close to the midline also facili- palatal surfaces.5 If full coverage porcelain and enhances accuracy.5 tates creation of an adequate contact point crowns are to be used, it is recommended with the adjacent central incisor, which in that they are constructed with a palatal Timing of restoration turn helps to provide adequate support for grove of sufficient depth to accommodate It is often difficult to determine the exact the interdental papilla.5,7 the multi-strand wire. space requirements for the final restoration

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a c Fig. 1 OPG radiograph showing space available for UR1, UL1 during orthodontic treatment. This can be simplified if the lateral incisor is temporarily enlarged to the final dimensions necessary to mimic a central incisor before orthodon- 5,7 tic treatment or before final space closure. b d Temporary enlargement can be achieved Figs 2a-d Intra-oral and extra-oral photographs revealing a Class III incisor relationship with with the use of direct composite resin or 1.5 units of space for UR1 and UL1. There is evidence of crowding in the lower labial segment the construction of a temporary crown using despite there only being three lower incisors autopolymerizing acrylic resin.5

Emergence profile incisor to mimic the adjacent central incisor As previously alluded to, mesial and dis- can adversely affect the appearance of the tal margins of the restoration on the lat- restoration. Periodontal surgical procedures, eral incisor must be over contoured for such as crown lengthening, in addition to adequate central incisor appearance and orthodontic intrusion, may need to be con- to compensate for the narrower cervical sidered. This would also facilitate retention width. If correctly constructed these over- of a large restoration on a smaller tooth. hangs provide support and pressure to a effectively sculpt the labial and interdental Periodontal health gingival tissues.5,14 The over-contoured mesial and distal mar- gins of the final restoration, although aes- Functional thetically necessary, may lead to plaque The root length of the substituted lateral retention, poor food shedding and perio- incisor is shorter than a central incisor and dontal pathology.7 Strict adherence to oral therefore it has been postulated that it will hygiene instructions is therefore manda- not be able to tolerate protrusive forces tory in order to maintain the health and b as effectively. Consequently, it has been the appearance of the treatment result. suggested that the artificial crown of the lateral incisor should be 0.5 mm shorter CASE EXAMPLES than the adjacent central incisor and that Case one the canine in the true lateral incisor posi- tion should be slightly longer than the A 19-year-old male attended the ortho- substituted lateral incisor, therefore allow- dontic clinic following an internal refer- ing these neighbouring teeth to take the ral from the restorative department. The 9 major load during mandibular excursions. patient had lost both maxillary central c If both central incisors are replaced then incisors following a traumatic injury aged Figs 3a-c Intra-oral pictures of the upper the substituted laterals and the canines 7 years. A previous course of orthodon- and lower fixed appliances. The lower should have equal crown heights.9 The use tic treatment had been undertaken but incisor has been extracted and light aligning archwires are in situ. The relationship of linked restorations should also be con- the patient failed to wear his retainers. is Class I sidered to spread the occlusal loads over a Consequently, a space of 8 mm had re- greater combined root surface area. opened between the upper right and left lateral incisors (Fig. 1). On examination segment despite there being only three Gingival margins there was a Class I skeletal pattern with lower incisors (Figs 2a‑d). As previously highlighted, incorrect gingi- a mild Class III incisor relationship. There The anterior spacing was difficult to val margin height of the substituted lateral was moderate crowding in the lower labial restore as the space was only sufficient

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for one tooth, which would give an unac- ceptable appearance. The options to close or open space were considered jointly by an orthodontic/restorative clinic. Opening the space would have required posterior extractions as well as long-term resto- rations with either implants or bridges to replace both missing central incisors. A treatment plan was therefore made to Fig. 5 The orthodontic brackets were close the space, accepting the difficulties Fig. 4 Once the upper lateral incisors had replaced to detail the position of the UR2 and of restoring the lateral incisors. The loss been approximated to the correct distance UL2 and space closure was then completed the brackets were removed and composite of another lower incisor to relieve lower to the correct space requirements for the build-ups placed on the UR2 and UL2 definitive restorations arch crowding and facilitate achieve- ment of a Class I incisor relationship was also planned. The orthodontic treatment was under- taken with upper and lower fixed self- ligating appliances (Damon, Ormco Ltd) and treatment progressed to close the anterior spacing (Figs 3a‑c). Towards the end of space closure the maxillary lateral incisors were built-up with composite a d resin to the desired dimensions to mimic central incisors and a vacuformed matrix was used (Fig. 4). Periodontal surgery to lengthen the right maxillary lateral incisor crown and to match the lateral incisors’ gingival margins was also undertaken. Orthodontic brackets were then replaced and space closure completed to the correct space requirements (Fig. 5). b e While the composite restorations were of reasonable appearance, the patient requested a more optimal aesthetic out- come. Therefore, following a risk-ben- efit discussion, on the day of appliance debond the lateral incisors were prepared for bonded porcelain crowns. The use of provisional composite restorations allowed for minimal tooth reduction. c f Nonetheless, tooth preparation did poten- Figs 6a-f The occlusion post-debond. A Class I incisor relationship has been achieved with tially jeopardise pulpal health, with the good alignment of the upper and lower arches loss of vitality reported in up to 20% of crowned teeth.15 It is therefore important to highlight that crown preparation is not the first choice option in such cases and the use of more conservative adhesive techniques should always be attempted first. For this patient, the crowns were constructed with a palatal groove to accommodate a multi-strand orthodon- tic retainer wire, which was bonded in place on the same day as the crowns and aimed to prevent unwanted reopening of a b the midline space. The patient was nota- Figs 7a and b Extra-oral pictures demonstrating a mild Class II skeletal relationship with an bly pleased with the final treatment result increased overjet (Figs 6a‑f).

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a d a

b b e

Figs 8a-e The intra-oral photographs show an increased overjet and traumatised upper anterior central incisors. There is crowding in the upper and lower anterior segments

c c

d a c Figs 10a-d Once space closure could begin the UL1 and UR1 could be extracted. Space Figs 9a-c The upper arch has a fixed closing mechanics were used to approximate appliance in place behind the upper central the UR2 and UL2. A rectangular arch wire incisors. Closing the UL2 and UR2 together was employed to mesialise the roots in was started before extraction of the UR1 addition to the crowns and UL1 to limit the aesthetic disadvantage of a larger anterior space

(Figs 8a‑e). A treatment plan was formu- lated to remove the traumatised anterior b teeth and disguise both maxillary lateral incisors as centrals. The orthodontic treatment was under- Case two teeth were splinted together. Both teeth taken with upper and lower fixed appli- A 13-year-old boy was referred to the were subsequently accessed for pulp extir- ances. Initially the maxillary central orthodontic department following treat- pation and a referral made to the ortho- incisors were left in situ to maintain ment to his traumatised anterior teeth. dontic department. some form of aesthetics until the space One year ago the patient had fallen and Following a clinical and radiographic closure stage when the extractions were traumatised both anterior teeth. The examination the patient presented with undertaken (Figs 9a‑c). Once in rectan- upper right central incisor (UR1) had been a Class II division 1 incisor relationship gular stainless steel working archwires avulsed and the upper left central inci- on a skeletal 2 base (Figs 7a and b). The (Figs 10a‑d) the maxillary lateral incisors sor (UL1) intruded. The UR1 had been re- overjet was increased at 11 mm and there were mesialised with a view to composite implanted one hour post-trauma and the was upper and lower dental crowding build-ups being placed after orthodontic

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treatment (Figs 11a‑d). Treatment pro- gressed uneventfully (Figs 12a‑e) and upper and lower removable retainers were fitted. Although treatment was offered to improve the appearance of the anterior teeth, in particular the positions of the gin- gival margins, the patient was extremely happy with the outcome and requested no a c further intervention (Figs 13a and b).

DISCUSSION This article describes one of the strategies for treating patients with one or two miss- ing maxillary central incisors. Space closure and substitution of central incisors by lateral incisors is, however, sometimes questioned.6 Concern has been expressed that the treat- b d ment result might not look ‘natural’, partic- Figs 11a-d During space closure, coil was used to prevent total space closure such that space ularly in patients with a unilateral missing for build ups was maintained. The canines were reshaped to resemble the lateral incisors central incisor. However, results which are almost indistinguishable from normal appearance can be produced, but indications for this selected approach (Table 2) must be present and attention to detail throughout treatment must be exercised.1,5,8,17,18 The recognised disadvantages of this treatment approach include: increased treatment com- plexity, requirement for integrated interdis- ciplinary management, increased functional a d load on the small lateral incisor root and a high risk of anterior space reopening. The latter is a particular problem and necessi- tates long-term orthodontic retention. The main advantages of this treatment approach in young patients with a missing central incisor is the permanence and bio- logical compatibility of the treatment result, allowing for treatment to be completed in b early adolescence soon after the fixed appli- ances are removed.19 Mesial movement of e the lateral incisor into the central incisor Figs 12a-e Post-debond pictures. Although space maintains alveolar bone height, along the disguised central incisors were small in size the patient was very happy with the with attached gingiva and the interdental appearance and didn’t wish for any further papilla, during the continuous growth of restorative modifications to improve the size, the dentofacial complex. Consequently the length and gingival margins ‘red aesthetics’, the appearance of the soft c tissue surrounding the tooth, can be main- tained, which may be difficult to obtain with restorative rehabilitation and notably implants. The need for temporary prosthetic Unfortunately, with regards to the manage- with the intact neighbouring central incisor tooth replacements, such as removable pros- ment of missing maxillary central incisors, in 20 patients consecutively treated with theses or resin retained bridges until growth there is an absence of research compar- unilateral space closure. Essentially, they is complete and implants can be considered, ing the functional and aesthetic results of demonstrated that treatment was time con- is also eliminated along with their associated various treatment modalities. One study by suming with a mean duration of 34 months; cost and maintenance implications. Czochrowska et al.14 has, however, com- the lateral incisor root was capable of sup- It is important to adopt evidence- pared biological features and the clinical porting a crown the size of a central incisor; based clinical practice whenever possible. appearance of the substituted lateral incisor periodontal health was not compromised

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the esthetic appearance of maxillary anterior teeth. Am J Orthod 1984; 86: 89–94. 7. Newsome P R, Cooke M S. Modifying upper lateral incisors to mimic missing central incisors: new ways to overcome old problems? Restorative Dent 1987; 3: 91–95, 97, 99. 8. Sabri R. Treatment of a class I crowded malocclu- sion with an ankylosed maxillary central incisor. Am J Orthod Dentofacial Orthop 2002; 122: 557–565. 9. Schwaninger B, Shaye R. Management of cases with upper incisors missing. Am J Orthod 1977; 71: 396–405. 10. Levin E I. Dental esthetics and the golden propor- tion. J Prosthet Dent 1978; 40: 244–252. a b 11. Gürel G. The science and art of porcelain laminate veneers. London: Quintessence, 2003. Figs 13a and b The extra-oral images reveal a good aesthetic outcome. The low smile line 12. Swift E J Jr, Friedman M J. Critical appraisal: porce- limits the show of gingival margin discrepancies from the lateral incisors and canines lain veneer outcomes, part II. J Esthet Restor Dent 2006; 18: 110–113. 13. Asher C, Lewis D H. The integration of orthodontic and restorative procedures in cases with missing and that all patients expressed satisfaction biological adaptation, are achievable as maxillary incisors. Br Dent J 1986; 160: 241–245. 14. Czochrowska E M, Skaare A B, Stenvik A, Zachrisson with the overall treatment result despite a long as specific treatment indications are B U. Outcome of orthodontic space closure with professionally assessed, aesthetical match present, excellent restorative support is a missing maxillary central incisor. Am J Orthod Dentofacial Orthop 2003; 123: 597–603. in only 50% of patients. Interestingly, these available and attention to detail is exer- 15. Saunders W P, Saunders E M. Prevalence of findings are similar to studies which com- cised throughout orthodontic treatment. periradicular periodontitis associated with crowned teeth in an adult Scottish subpopulation. Br Dent J pared autotransplanted premolars placed 1998; 185: 137–140. The authors would like to acknowledge Jonathan 16. Antosz M. Space closure for a missing central in the missing central incisor position with Smith who undertook the orthodontic treatment for incisor. Am J Orthod Dentofacial Orthop 2003; the second case example. the intact neighbouring central incisor.20,21 124: 18A. Overall, this evidence would appear to 17. Hellekant M, Twetman S, Carlsson L. Treatment of 1. Kokich V G, Crabill K E. Managing the patient with a class II division 1 malocclusion with macrodon- support the clinical practice of orthodontic missing or malformed maxillary central incisors. Am tia of the maxillary central incisors. Am J Orthod J Orthod Dentofacial Orthop 2006; 129: S55–S63. space closure and lateral incisor substitu- Dentofacial Orthop 2001; 119: 654–659. 2. Bowden D E, Patel H A. Autotransplantation of 18. Janson G, Valarelli D P, Valarelli F P, de Freitas M R, tion in appropriate patients. premolar teeth to replace missing maxillary central Pinzan A. Atypical extraction of maxillary central incisors. Br J Orthod 1990; 17: 21–28. incisors. Am J Orthod Dentofacial Orthop 2010; 3. Zachrisson B U. Improving orthodontic results in 138: 510–517. CONCLUSION cases with maxillary incisors missing. Am J Orthod 19. Stenvik A, Zachrisson B U. Missing anterior teeth: 1978; 73: 274–289. orthodontic closure and transplantation as viable Orthodontic space closure with the sub- 4. Zachrisson B U, Rosa M, Toreskog S. Congenitally options to conventional replacements. Endod Topics stitution of a maxillary central incisor by missing maxillary lateral incisors: canine substitu- 2006; 14: 41–50. tion. Am J Orthod Dentofacial Orthop 2011; 139: 20. Czochrowska E M, Stenvik A, Zachrisson B U. The a lateral incisor, although a clinical chal- 434, 436, 438. esthetic outcome of autotransplanted premolars lenge, is a viable treatment approach to 5. Chaushu S, Becker A, Zalkind M. Prosthetic con- replacing maxillary incisors. Dent Traumatol 2002; siderations in the restoration of orthodontically 18: 237–245. manage the rare clinical problem of a miss- treated maxillary lateral incisors to replace missing 21. Czochrowska E M, Stenvik A, Album B, Zachrisson ing maxillary central incisor. Functional central incisors: a clinical report. J Prosthet Dent B U. Autotransplantation of premolars to replace 2001; 85: 335–341. maxillary incisors: a comparison with natural and aesthetically satisfactory results, 6. Kokich V G, Nappen D L, Shapiro P A. Gingival incisors. Am J Orthod Dentofacial Orthop 2000; which demonstrate permanence and good contour and clinical crown length: their effect on 118: 592–600.

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