Uniprot name Protein name Gene name Peptides OT1 - TPIN-SC(CD62Lhi)/OT1 - TNE-SC(CD62Llo) OT1 - TPIN-SC(CD62Lhi)/OT1 - TPIN-SC(CD62Llo) Log2 (ratio) Counts Log10 (Summed Significance B Log2 (ratio) Counts Log10 (Summed Significance B Intensities) Intensites) O08797 Protein Serpinb9 Serpinb9 5 1,6950 8 6,3029 0,0000 -0,2205 7 6,7278 0,5314 E9Q5W7 L-selectin Sell 2 1,4661 2 5,6553 0,0000 0,9395 4 6,3054 0,3946 Q544R1 Proline synthase co-transcribed Prosc 2 1,4208 2 6,1679 0,0000 0,5063 2 5,7559 0,7523 bacterial homolog protein O09159 Lysosomal alpha-mannosidase Man2b1 3 1,1965 2 5,4603 0,0000 NaN 1 5,1854 1,0000 E9PUM4 Talin-2 Tln2 19 1,1659 2 7,2477 0,0000 NaN 0 NaN 1,0000 Q3V157 Signal transducer and activator of Stat4 5 0,9376 3 5,7622 0,0000 0,1255 10 6,6896 0,8677 transcription 4 A2RSY6 TRMT1-like protein Trmt1l 2 0,8718 2 5,6063 0,0000 NaN 0 NaN 1,0000 P07356 Annexin A2 Anxa2 16 0,8307 15 6,9356 0,0000 0,9899 19 7,4857 0,4938 Q3UD32 Cathepsin S Ctss 4 0,8148 6 6,4179 0,0000 0,5122 5 6,7013 0,7468 Q8BV49 Pyrin and HIN domain-containing Pyhin1 6 0,7389 4 6,3847 0,0001 0,0098 5 6,9368 0,7255 protein 1 A2A4L8 SWI/SNF-related matrix- Smarce1 2 0,7367 2 5,5580 0,0001 NaN 1 6,0717 1,0000 associated actin-dependent regulator of chromatin subfamily E member 1 Q7TPR4 Alpha-actinin-1 Actn1 37 0,6753 16 6,8461 0,0000 1,0007 16 7,3022 0,4868 Q6IRU2 Tropomyosin alpha-4 chain Tpm4 8 0,6405 5 6,6265 0,0000 0,5613 5 6,8943 0,8061 E9Q2W5 YTH domain family protein 3 Ythdf2 2 0,6162 2 7,8124 0,0000 NaN 1 7,4648 1,0000 O08738 Caspase-6 Casp6 3 0,5895 2 5,3708 0,0016 NaN 0 NaN 1,0000 Q60790 Ras GTPase-activating protein 3 Rasa3 3 0,5799 3 5,5478 0,0019 NaN 1 5,6291 1,0000 Q9WVA4 Transgelin-2 Tagln2 17 0,5722 26 7,7332 0,0002 2,3596 27 8,0217 0,0369 P17751 Triosephosphate isomerase Tpi1 22 0,5622 29 7,9373 0,0002 1,5262 29 8,2343 0,2174 Q9JKV1 Proteasomal ubiquitin receptor Adrm1 2 0,5270 2 5,7517 0,0047 NaN 0 NaN 1,0000 ADRM1 P09411 Phosphoglycerate kinase 1 Pgk1 37 0,5153 78 8,8397 0,0007 1,2595 46 8,7332 0,3369 Q8VDP4 DBIRD complex subunit KIAA1967 5 0,5130 5 6,1949 0,0059 1,0533 2 5,7730 0,3212 homolog Q3UM45 Protein phosphatase 1 regulatory Ppp1r7 4 0,5031 2 6,0770 0,0070 1,3108 5 6,8583 0,3111 subunit 7 P08882 Granzyme C Gzmc 7 0,5026 3 5,5884 0,0070 -0,8068 8 6,6020 0,1604 G3X8V7 Dehydrogenase/reductase SDR Dhrs4 2 0,4776 2 5,5963 0,0104 -0,5076 2 5,8342 0,3140 family member 4 Q8K212 Phosphofurin acidic cluster Pacs1 2 0,4756 3 7,0835 0,0017 NaN 1 6,8509 1,0000 sorting protein 1 A2APB0 Ras association domain- Rassf2 2 0,4699 2 5,8000 0,0117 -1,7540 3 6,3781 0,0078 containing protein 2 Q3U5Q7 UMP-CMP kinase 2, Cmpk2 4 0,4640 3 5,8947 0,0128 NaN 1 5,9217 1,0000 mitochondrial H3BJQ7 Peroxiredoxin-5, mitochondrial Prdx5 7 0,4244 12 6,8335 0,0051 1,5057 5 6,5802 0,1208 A7VJA4 Glia maturation factor gamma Gmfg 6 0,4203 5 6,5039 0,0241 1,7364 4 6,1648 0,0663 Q62293 T-cell specific GTPase Tgtp 12 0,4172 9 7,4390 0,0059 0,6574 13 7,7309 0,7310 Q921M7 Protein FAM49B Fam49b 14 0,4103 19 7,2253 0,0067 1,6433 17 7,5887 0,1760 P17182 Alpha-enolase Eno1 41 0,4036 91 9,3286 0,0077 1,0965 57 9,0834 0,4275 P12382 6-phosphofructokinase, liver type Pfkl 20 0,4001 17 7,0726 0,0082 0,0401 27 7,5101 0,7513

P70677 Caspase-3 Casp3 9 0,3936 14 6,7163 0,0093 0,7133 8 6,5049 0,5677 P08414 Calcium/calmodulin-dependent Camk4 3 0,3870 2 5,9624 0,0378 NaN 1 5,7048 1,0000 protein kinase type IV P52480 Pyruvate kinase isozymes M1/M2 Pkm2 39 0,3865 67 8,4856 0,0107 1,0119 34 8,8193 0,4797

Q8BGW0 Protein THEMIS Themis 11 0,3861 19 7,2028 0,0107 0,9863 10 7,1067 0,4961 Q3U3B7 Inositol monophosphatase 2 Impa2 4 0,3845 3 5,7489 0,0391 1,1740 4 6,5429 0,2538 Q8BJS4 SUN domain-containing protein 2 Sun2 8 0,3746 6 6,3396 0,0444 -0,7153 14 7,3637 0,2429

Q8VI63 MOB kinase activator 2 Mob2 3 0,3712 2 5,3867 0,0464 -0,7026 2 5,5207 0,2057 O08529 Calpain-2 catalytic subunit Capn2 4 0,3684 4 6,1532 0,0480 0,6273 3 5,9942 0,6418 Q99JF8 PC4 and SFRS1-interacting Psip1 2 0,3664 2 6,9437 0,0155 0,3924 3 6,6610 0,8613 protein A2AB61 Formin-like protein 1 Fmnl1 24 0,3600 29 7,5750 0,0174 1,4312 17 7,4182 0,2559 P62852 40S ribosomal protein S25 Rps25 5 0,3595 4 6,8781 0,0175 -0,1072 9 7,3668 0,6291 Q3U7Z6 Phosphoglycerate mutase 1 Pgam1 20 0,3449 33 7,9745 0,0226 2,0025 32 8,3756 0,0852 G5E8N5 L-lactate dehydrogenase Ldha 29 0,3374 42 8,5068 0,0257 1,2809 56 8,9786 0,3260 Q99LX0 Protein DJ-1 Park7 9 0,3361 13 7,4160 0,0263 1,6947 18 7,5669 0,1597 Q9CWJ9 Bifunctional purine biosynthesis Atic 14 0,3345 9 6,7705 0,0271 0,8891 10 7,4666 0,5612 protein PURH E9Q447 Spectrin alpha chain, brain Spna2 43 0,3237 35 7,4430 0,0324 0,8865 22 7,0579 0,5630 D3Z7R7 Minor histocompatibility protein Hmha1 14 0,2968 21 7,1411 0,0497 1,6972 9 6,9515 0,1590 HA-1 P97310 DNA replication licensing factor Mcm2 26 -0,3947 32 7,4929 0,0418 0,0422 19 7,3342 0,7531 MCM2 P19157 Glutathione S-transferase P 1 Gstp1 10 -0,3980 17 7,7402 0,0402 1,3878 25 7,6731 0,2750 O08749 Dihydrolipoyl dehydrogenase, Dld 8 -0,4015 10 6,9509 0,0384 -0,3339 10 7,5631 0,4604 mitochondrial P67778 Prohibitin Phb 12 -0,4144 17 7,3570 0,0326 -0,5685 21 7,8734 0,3161 G3X8T3 Lysosomal protective protein Ctsa 6 -0,4154 6 6,7675 0,0322 1,8389 8 6,9674 0,1203 P29351-2 Tyrosine-protein phosphatase Ptpn6 14 -0,4179 11 7,0530 0,0312 0,3610 11 6,8177 0,9678 non-receptor type 6 G3UWA6 4F2 cell-surface antigen heavy Slc3a2 7 -0,4541 10 6,8165 0,0192 -0,0305 15 7,1149 0,6917 chain A2AJX5 DENN domain-containing protein Dennd4c 3 -0,4566 2 5,7980 0,0462 NaN 0 NaN 1,0000 4C P08003 Protein disulfide-isomerase A4 Pdia4 8 -0,4568 5 6,3880 0,0461 -0,6354 10 6,8522 0,2811 F8WJ19 Interferon-induced very large Gvin1 60 -0,4686 64 7,8146 0,0157 0,5174 47 7,5127 0,8411 GTPase 1 Q9Z2Z6 Mitochondrial Slc25a20 5 -0,4824 2 5,8399 0,0352 -0,0428 4 6,4445 0,6966 carnitine/acylcarnitine carrier protein Q91WD5 NADH dehydrogenase Ndufs2 4 -0,4839 3 6,0790 0,0346 -0,9711 4 6,6061 0,1048 [ubiquinone] iron-sulfur protein 2, mitochondrial Q9CZ13 Cytochrome b-c1 complex Uqcrc1 15 -0,4845 12 7,1063 0,0124 -0,9390 13 7,4268 0,1557 subunit 1, mitochondrial Q543N5 Chloride intracellular channel Clic4 7 -0,4914 3 6,3515 0,0319 0,2672 4 6,2372 0,9841 protein 4 Q9CQW2 ADP-ribosylation factor-like Arl8b 3 -0,4975 2 6,2931 0,0298 -0,4700 4 6,8117 0,3727 protein 8B Q922U1 U4/U6 small nuclear Prpf3 3 -0,5014 3 5,2658 0,0286 0,2502 2 5,9562 0,9991 ribonucleoprotein Prp3 O54879 High mobility group protein B3 Hmgb3 4 -0,5144 2 6,0490 0,0247 1,6230 3 6,1522 0,0898 P17918 Proliferating cell nuclear antigen Pcna 13 -0,5150 19 7,4318 0,0079 0,5103 19 7,5336 0,8468 P00405 Cytochrome c oxidase subunit 2 Mtco2 6 -0,5164 10 7,0302 0,0077 -0,5004 10 7,3351 0,3546 Q9DB77 Cytochrome b-c1 complex Uqcrc2 13 -0,5166 11 7,3178 0,0077 -1,1396 15 7,8109 0,0998 subunit 2, mitochondrial A2AQR0 Glycerol-3-phosphate Gpd2 8 -0,5180 6 6,1713 0,0237 -1,4166 15 6,8479 0,0503 dehydrogenase, mitochondrial P50518 V-type proton ATPase subunit E 1 Atp6v1e1 3 -0,5253 5 6,1080 0,0218 NaN 0 NaN 1,0000

P57759 Endoplasmic reticulum resident Erp29 4 -0,5376 3 5,8279 0,0189 -0,6328 8 6,4897 0,2408 protein 29 Q99K70 Ras-related GTP-binding protein C Rragc 2 -0,5477 2 6,0414 0,0168 NaN 1 5,3906 1,0000

P51150 Ras-related protein Rab-7a Rab7a 11 -0,5511 19 7,2798 0,0045 0,3136 14 7,3132 0,9928 P62814 V-type proton ATPase subunit B, Atp6v1b2 3 -0,5539 2 6,0009 0,0156 0,5795 2 6,6099 0,6847 brain isoform P29391 Ferritin light chain 1 Ftl1 12 -0,5773 24 7,6472 0,0029 0,2991 9 7,1394 0,9798 P15702 Leukosialin Spn 4 -0,5811 3 6,5475 0,0111 NaN 1 6,2544 1,0000 P04187 Granzyme B(G,H) Gzmb 16 -0,5880 20 7,4775 0,0024 -1,4267 30 7,9187 0,0490 P16460 Argininosuccinate synthase Ass1 3 -0,5982 3 6,1894 0,0090 NaN 1 5,8989 1,0000 Q9QZ85 Interferon-inducible GTPase 1 Iigp1 5 -0,6094 3 6,5916 0,0078 0,1511 3 6,3210 0,8944 Q9D6J5 NADH dehydrogenase Ndufb8 2 -0,6221 3 5,9338 0,0066 -0,6035 3 6,2550 0,2568 [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial Q9D2G2 Dihydrolipoyllysine-residue Dlst 2 -0,6363 4 6,4513 0,0054 -0,7532 7 6,8327 0,2261 succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Q9D0M3 Cytochrome c1, heme protein, Cyc1 6 -0,6481 6 6,5436 0,0046 -0,0969 9 6,7691 0,6442 mitochondrial Q99MN9 Propionyl-CoA carboxylase beta Pccb 3 -0,6998 2 5,6088 0,0022 NaN 1 5,6860 1,0000 chain, mitochondrial Q9Z1Z0 General vesicular transport factor Uso1 4 -0,7234 2 5,6018 0,0016 NaN 1 5,8059 1,0000 p115 Q9JMH6 Thioredoxin reductase 1, Txnrd1 2 -0,7884 2 6,6378 0,0000 NaN 1 6,4901 1,0000 cytoplasmic E9Q8V6 Protein Dennd4a Dennd4a 4 -0,8357 2 5,6765 0,0003 NaN 1 5,0923 1,0000 Q8C129 Leucyl-cystinyl aminopeptidase Lnpep 22 -0,8386 33 7,6582 0,0000 -0,0181 16 7,0873 0,7020 A2AH25 Rho GTPase-activating protein 1 Arhgap1 3 -0,8565 2 6,5491 0,0002 NaN 0 NaN 1,0000 Q8BH95 Enoyl-CoA hydratase, Echs1 6 -0,8589 3 6,0123 0,0002 0,7182 9 6,5826 0,5636 mitochondrial O35405 Phospholipase D3 Pld3 3 -0,8939 2 6,1372 0,0001 NaN 1 6,3228 1,0000 P17047-2 Lysosome-associated membrane Lamp2 2 -0,9059 4 6,3766 0,0001 -0,5395 3 6,2163 0,2941 glycoprotein 2 Q9D379 Epoxide hydrolase 1 Ephx1 2 -0,9191 2 5,8626 0,0001 NaN 0 NaN 1,0000 P26011 Integrin beta-7 Itgb7 7 -1,0656 6 6,8086 0,0000 NaN 1 6,1814 1,0000 Q8R502 Leucine-rich repeat-containing Lrrc8c 2 -1,1705 2 5,3924 0,0000 NaN 0 NaN 1,0000 protein 8C O35114 Lysosome membrane protein 2 Scarb2 2 -1,2155 2 5,8691 0,0000 NaN 1 5,7700 1,0000 Q60677 Integrin alpha-E Itgae 14 -1,2231 16 7,3844 0,0000 0,7149 3 6,2498 0,5663 Q8C243 Cathepsin D Ctsd 8 -1,2690 15 7,3770 0,0000 0,7727 4 7,2140 0,6441 Q61024 Asparagine synthetase [glutamine- Asns 2 -3,9920 2 7,8773 0,0000 NaN 0 NaN 1,0000 hydrolyzing] Q3UV17 Keratin, type II cytoskeletal 2 oral Krt76 7 -5,0048 2 7,7418 0,0000 -5,6676 3 6,6419 0,0000

F8WIL9 Engulfment and cell motility Elmo1 14 0,2962 16 6,8922 0,0502 0,4015 12 6,9320 0,9348 protein 1 Q6PDC2 Transmembrane emp24 domain- Tmed9 8 -0,4445 10 6,4826 0,0523 0,1177 12 7,1120 0,8184 containing protein 9 Q5F1Z8 Ganglioside GM2 activator Gm2a 6 0,3578 5 6,5769 0,0548 2,6463 9 7,1385 0,0173 P54071 Isocitrate dehydrogenase [NADP], Idh2 8 0,2895 9 6,6986 0,0556 -0,2867 6 6,8448 0,4933 mitochondrial Q9DB15 39S ribosomal protein L12, Mrpl12 2 -0,4377 2 5,5233 0,0560 NaN 1 5,2660 1,0000 mitochondrial Q8C483 Serine--tRNA ligase, cytoplasmic Sars 9 -0,3679 6 6,6423 0,0579 0,2990 7 6,8860 0,9797 P47791 Glutathione reductase, Gsr 2 -0,4345 3 5,9947 0,0579 NaN 1 5,9280 1,0000 mitochondrial Q3U4X8 DNA ligase Lig1 10 -0,4304 10 6,5776 0,0603 -0,1166 9 6,6363 0,6256 Q9R1T2 SUMO-activating enzyme subunit Sae1 7 -0,3636 4 6,6838 0,0609 0,4837 7 7,0419 0,8682 1 P09528 Ferritin heavy chain Fth1 5 -0,3635 8 7,0343 0,0609 -0,3531 13 6,9998 0,4474 Q9Z0E6 Interferon-induced guanylate- Gbp2 7 -0,3598 5 6,8055 0,0636 0,1233 6 6,7004 0,8653 binding protein 2 Q9D2V7 Coronin-7 Coro7 7 0,3447 8 6,5448 0,0643 0,6668 3 6,2556 0,6073 F6UF97 Nicastrin Ncstn 3 -0,4239 3 6,1251 0,0643 NaN 0 NaN 1,0000 Q62422 Osteoclast-stimulating factor 1 Ostf1 6 0,3428 7 6,5809 0,0658 1,2982 6 7,0033 0,3173 Q3U1V3 Beta-adrenergic receptor kinase 1 Adrbk1 4 0,3402 4 6,1389 0,0679 0,4258 6 6,5832 0,8290

Q99KC8 von Willebrand factor A domain- Vwa5a 17 0,2739 21 7,0429 0,0700 0,7685 10 7,0085 0,6472 containing protein 5A P19973 Lymphocyte-specific protein 1 Lsp1 8 0,2723 13 7,3149 0,0718 1,3450 4 6,8851 0,2947 Q99N69 Leupaxin Lpxn 3 0,3354 4 6,1808 0,0718 NaN 0 NaN 1,0000 Q8C2K1 Differentially expressed in FDCP 6 Def6 2 0,3343 3 5,9227 0,0727 NaN 0 NaN 1,0000

Q62261 Spectrin beta chain, brain 1 Sptbn1 49 0,2713 33 7,3784 0,0728 0,7367 41 7,3534 0,6708 B1ASP2 Tyrosine-protein kinase Jak1 2 -0,4111 2 5,4120 0,0728 NaN 0 NaN 1,0000 P27546 Microtubule-associated protein 4 Map4 7 0,3334 6 6,2806 0,0735 NaN 1 5,0813 1,0000

Q01730 Ras suppressor protein 1 Rsu1 4 -0,4094 4 5,7526 0,0739 0,5154 2 5,6620 0,7438 Q60930 Voltage-dependent anion- Vdac2 10 -0,3460 17 7,4863 0,0745 -0,6466 24 8,0445 0,2756 selective channel protein 2 Q00612 Glucose-6-phosphate 1- G6pdx 4 -0,3455 4 6,6035 0,0750 NaN 0 NaN 1,0000 dehydrogenase X F6SJE0 Phosphatidylinositol transfer Pitpna 3 0,3294 2 5,9189 0,0770 1,1780 2 6,4190 0,2517 protein alpha isoform H3BL37 Treacle protein Tcof1 2 -0,4033 2 5,6957 0,0784 0,0873 2 5,0260 0,8280 P70122 Ribosome maturation protein Sbds 3 0,3265 2 5,5663 0,0796 0,4060 5 6,7440 0,8481 SBDS P26443 Glutamate dehydrogenase 1, Glud1 15 0,2640 15 7,2031 0,0808 -0,0651 7 7,4551 0,6632 mitochondrial Q8C1A5 Thimet oligopeptidase Thop1 6 0,2640 8 7,1957 0,0808 -0,2932 2 5,4445 0,4701 Q4V9W8 Ras-related protein Rab-4B Rab4b 2 -0,3997 3 5,6206 0,0811 NaN 0 NaN 1,0000 P01901 H-2 class I histocompatibility H2-K1 8 -0,3380 14 7,5065 0,0815 0,4639 5 7,3918 0,8841 antigen, K-B alpha chain Q9DCX2 ATP synthase subunit d, Atp5h 10 -0,3369 10 7,1258 0,0825 -0,2690 16 7,4531 0,5060 mitochondrial Q3TML0 Protein disulfide-isomerase A6 Pdia6 8 -0,3368 8 7,0162 0,0825 -0,6014 6 6,9724 0,2986 Q8K4Z3 NAD(P)H-hydrate epimerase Apoa1bp 4 -0,3971 4 6,1553 0,0831 0,6116 4 6,3987 0,6558 Q3U367 4-trimethylaminobutyraldehyde Aldh9a1 6 0,2615 8 7,0846 0,0837 0,6454 4 7,2678 0,7402 dehydrogenase Q08642 Protein-arginine deiminase type-2 Padi2 6 -0,3352 9 6,6908 0,0841 0,2261 6 6,4413 0,9736

Q91Z40 Guanylate binding protein 7 Gbp7 8 0,2611 8 7,0855 0,0841 1,0121 4 6,8369 0,4796 Q8VI93 2'-5'-oligoadenylate synthase 3 Oas3 5 0,3198 7 6,3344 0,0859 0,3715 3 6,3775 0,8816 P43276 Histone H1.5 Hist1h1b 13 -0,3330 8 6,8546 0,0861 -1,9780 16 8,0136 0,0096 G3X987 Protein Gimap9 Gimap9 7 -0,3317 9 6,8728 0,0873 0,7822 6 6,7562 0,5113 G5E924 Heterogeneous nuclear Hnrnpl 7 0,2580 8 6,6247 0,0879 -0,2459 4 6,7932 0,5096 ribonucleoprotein L P06745 Glucose-6-phosphate isomerase Gpi 20 0,2576 28 7,7491 0,0884 1,7964 10 7,7116 0,1310 Q3U505 Dolichyl- Rpn2 8 -0,3898 4 6,3616 0,0889 -0,5958 8 7,4218 0,3016 diphosphooligosaccharide-- protein glycosyltransferase subunit 2 Q922B2 Aspartate--tRNA ligase, Dars 14 0,2552 13 7,1100 0,0914 0,1023 10 7,8819 0,8050 cytoplasmic O35129 Prohibitin-2 Phb2 22 -0,3270 26 7,3460 0,0919 -0,5515 30 8,0625 0,3255 D4AFX7 Receptor mediated endocytosis-8 Dnajc13 13 -0,3850 5 6,2724 0,0929 -0,6311 13 6,5402 0,2417

E9QQ06 H-2 class I histocompatibility H2-D1 12 -0,3236 19 7,8326 0,0953 -0,0514 10 7,4333 0,6744 antigen, D-B alpha chain Q3TYK4 cAMP-dependent protein kinase Prkar1a 6 -0,3226 7 6,7955 0,0963 0,3546 4 6,9373 0,9731 type I-alpha regulatory subunit E9QPT2 Condensin complex subunit 1 Ncapd2 7 -0,3225 8 6,9922 0,0965 2,7324 2 7,0307 0,0136 E9QA63 Microtubule-actin cross-linking Macf1 9 0,2478 6 7,2962 0,1011 -1,1561 2 5,4614 0,0618 factor 1 E9Q120 Lon protease homolog Lonp1 21 0,2477 17 6,8849 0,1013 -0,8595 20 7,4232 0,1835 Q61699 Heat shock protein 105 kDa Hsph1 11 -0,3174 9 6,6673 0,1019 0,6118 2 6,1747 0,6556 Q9D0F9 Phosphoglucomutase-1 Pgm1 6 0,2454 6 6,6127 0,1045 NaN 1 5,7312 1,0000 Q61823 Programmed cell death protein 4 Pdcd4 6 0,2442 7 6,9300 0,1062 2,1906 2 6,7659 0,0165

E9QN87 Plectin Plec 104 0,2428 103 7,6492 0,1082 -0,0279 32 6,9344 0,6939 Q3UPL0 Protein transport protein Sec31A Sec31a 4 0,2974 3 5,9445 0,1103 NaN 1 5,3145 1,0000

Q9CQ22 Ragulator complex protein Lamtor1 2 -0,3652 2 5,9624 0,1110 0,1413 3 6,4435 0,8842 LAMTOR1 Q6NZJ6 Eukaryotic translation initiation Eif4g1 6 0,2962 2 5,7380 0,1117 -0,2317 3 5,9028 0,5218 factor 4 gamma 1 Q9CW46 Ribonucleoprotein PTB-binding 1 Raver1 4 0,2961 3 5,9350 0,1118 0,4689 3 5,9611 0,7876

A2AS84 Dipeptidyl peptidase 4 Dpp4 13 0,2400 16 7,2683 0,1123 -0,0888 9 7,1676 0,6440 Q8C845 EF-hand domain-containing Efhd2 6 -0,3596 4 6,1060 0,1166 1,6505 3 6,1416 0,0836 protein D2 P56480 ATP synthase subunit beta, Atp5b 26 -0,3029 77 8,5338 0,1186 -0,8019 29 8,7710 0,2058 mitochondrial Q8CGY8 UDP-N-acetylglucosamine-- Ogt 4 -0,3577 2 5,6506 0,1186 0,3561 4 6,2556 0,8966 peptide N- acetylglucosaminyltransferase 110 kDa subunit F6TN59 Serine/threonine-protein kinase Stk10 7 0,2354 8 6,7807 0,1194 1,1643 3 6,3558 0,2588 10 Q7TQH0-2 Ataxin-2-like protein Atxn2l 3 -0,3530 2 5,9414 0,1235 NaN 0 NaN 1,0000 P68368 Tubulin alpha-4A chain Tuba4a 23 -0,2978 10 7,5693 0,1250 0,1730 2 6,4265 0,9175 Q5I0W0 ATP synthase subunit b, Atp5f1 11 -0,2972 5 7,0773 0,1257 -0,0809 17 7,6753 0,6504 mitochondrial B2RUR0 FYN-binding protein Fyb 5 0,2819 4 6,3393 0,1300 1,5357 4 6,5030 0,1122 Q9ES61 Chandra protein Ms4a4b 2 -0,3465 2 5,5043 0,1306 NaN 0 NaN 1,0000 P63260 Actin, cytoplasmic 2 Actg1 44 0,2279 7 7,8744 0,1316 -1,6793 6 7,6836 0,0242 Q3U5I5 Growth factor receptor-bound Grb2 6 0,2806 5 6,4189 0,1318 1,7820 9 7,0088 0,1348 protein 2 Q3U335 Serine/threonine-protein kinase Stk24 5 0,2777 4 6,5633 0,1357 0,8310 4 6,9088 0,6020 24 Q8BTS0 Probable ATP-dependent RNA Ddx5 9 0,2773 6 6,4385 0,1364 -0,3078 7 7,0953 0,4784 helicase DDX5 Q8VDW0 ATP-dependent RNA helicase Ddx39a 18 -0,2889 4 6,9325 0,1366 -0,6543 3 6,8526 0,2718 DDX39A P35564 Calnexin Canx 12 -0,2884 16 7,2359 0,1373 -0,3869 13 7,0299 0,4250 B1AWD5 Golgi-associated plant Glipr2 5 -0,2882 6 7,0133 0,1376 0,7465 4 6,8460 0,6635 pathogenesis-related protein 1 F8VPM4 Heterogeneous nuclear Hnrnpul2 13 0,2234 10 6,6713 0,1392 0,2120 8 6,9489 0,9018 ribonucleoprotein U-like protein 2 Q9DB20 ATP synthase subunit O, Atp5o 16 -0,2867 21 7,5375 0,1396 -0,3871 27 7,8764 0,4248 mitochondrial F7BBI3 40S ribosomal protein S17 Rps17 11 0,2214 12 6,9489 0,1427 -0,1367 14 7,3813 0,6057 Q3TEE6 Fermitin family homolog 3 Fermt3 17 0,2203 21 7,4006 0,1448 1,1368 34 7,7587 0,4039 Q99KI0 Aconitate hydratase, Aco2 30 -0,2819 31 7,5269 0,1464 0,2756 36 7,7868 0,9587 mitochondrial Q9EQH2 Endoplasmic reticulum Erap1 22 -0,2786 23 7,3305 0,1513 -0,7301 13 7,2559 0,2362 aminopeptidase 1 A2AUF6 78 kDa glucose-regulated protein Hspa5 33 -0,2775 41 8,0130 0,1529 -1,1271 55 8,1429 0,1028

P51410 60S ribosomal protein L9 Rpl9 7 0,2133 6 6,6648 0,1581 -0,1031 11 7,2332 0,6324 P97384 Annexin A11 Anxa11 7 -0,2731 8 6,9541 0,1595 1,1576 3 7,1387 0,3920 Q3TBT3-2 Transmembrane protein 173 Tmem173 5 0,2614 3 5,8190 0,1603 -0,2958 8 6,6675 0,4680 Q8R5J9 PRA1 family protein 3 Arl6ip5 3 0,2592 2 5,7842 0,1638 0,0456 4 6,3429 0,7851 Q03265 ATP synthase subunit alpha, Atp5a1 38 -0,2700 55 8,3703 0,1643 -0,6207 48 8,8724 0,2886 mitochondrial Q91YQ5 Dolichyl- Rpn1 5 -0,3184 3 5,9290 0,1649 -1,9588 3 6,1955 0,0034 diphosphooligosaccharide-- protein glycosyltransferase subunit 1 P14576 Signal recognition particle 54 kDa Srp54 2 -0,3181 2 6,0010 0,1653 NaN 0 NaN 1,0000 protein A2A9X6 5(3)-deoxyribonucleotidase, Nt5c 3 0,2576 5 6,5473 0,1663 1,3328 6 6,8154 0,3005 cytosolic type Q61735-2 Leukocyte surface antigen CD47 Cd47 4 -0,3172 4 6,5352 0,1664 0,3924 6 6,9213 0,9422 Q6ZQ84 Cullin-3 Cul3 6 -0,3170 2 5,4387 0,1668 0,4549 3 6,0505 0,8010 A4FUS1 40S ribosomal protein S16 Rps16 12 0,2083 19 7,5430 0,1680 -0,3046 21 7,5975 0,4807 E9Q616 Protein Ahnak Ahnak 56 -0,2674 70 7,7213 0,1684 0,3082 23 7,0967 0,9880 Q80X90 Filamin-B Flnb 10 0,2560 2 5,4297 0,1689 0,4697 5 5,9605 0,7869 P97372 Proteasome activator complex Psme2 15 0,2074 11 7,5819 0,1698 1,5846 23 7,7721 0,1959 subunit 2 Q544H0 Eukaryotic translation initiation Eif3g 4 0,2540 5 6,5551 0,1724 NaN 1 5,9487 1,0000 factor 3 subunit G Q544F6 Coactosin-like protein Cotl1 5 0,2534 2 5,9425 0,1734 1,4553 4 6,5179 0,1365 Q9QYC0 Alpha-adducin Add1 4 0,2531 2 5,8515 0,1738 1,0845 3 6,0867 0,3028 O08582 GTP-binding protein 1 Gtpbp1 4 0,2521 4 6,1616 0,1756 -0,0585 3 6,0244 0,6812 Q9D8L3 Translocon-associated protein Ssr4 2 -0,3105 2 5,7141 0,1757 -0,5163 2 5,7781 0,3085 subunit delta Q9JIK5 Nucleolar RNA helicase 2 Ddx21 12 0,2512 9 6,5907 0,1771 -0,1130 12 6,7951 0,6290 E9Q0H7 Prolyl endopeptidase Prep 12 -0,2616 13 7,1122 0,1779 0,4037 18 7,1239 0,9330 P24547 Inosine-5-monophosphate Impdh2 8 -0,2615 8 6,9580 0,1781 0,2104 5 7,2785 0,9003 dehydrogenase 2 O54734 Dolichyl- Ddost 12 -0,2613 15 7,3414 0,1783 -0,9918 17 7,5838 0,1391 diphosphooligosaccharide-- protein glycosyltransferase 48 kDa subunit O70503 Estradiol 17-beta-dehydrogenase Hsd17b12 4 -0,3075 2 5,6520 0,1798 -1,1888 4 6,3261 0,0560 12 E9QAC7 Glyceraldehyde-3-phosphate Gm3839 29 0,2494 2 6,3573 0,1802 NaN 1 6,7508 1,0000 dehydrogenase Q6PFD9 Nuclear pore complex protein Nup98 5 0,2485 5 6,0206 0,1817 0,0977 3 5,8125 0,8388 Nup98-Nup96 Q9D0L8 mRNA cap guanine-N7 Rnmt 6 0,2483 7 6,4858 0,1821 NaN 1 6,3978 1,0000 methyltransferase P68181-4 cAMP-dependent protein kinase Prkacb 9 -0,2587 8 6,6371 0,1828 0,1862 10 7,2200 0,8789 catalytic subunit beta Q3TEA8 Heterochromatin protein 1- Hp1bp3 19 0,2011 9 7,1447 0,1830 -0,4414 29 7,7253 0,3902 binding protein 3 Q80UU9 Membrane-associated Pgrmc2 2 -0,3036 4 5,7303 0,1855 -0,0111 4 6,3222 0,7279 progesterone receptor component 2 Q08093 Calponin-2 Cnn2 4 0,1998 4 6,7221 0,1860 1,6424 5 6,9856 0,1762 P23591 GDP-L-fucose synthase Tsta3 6 0,2460 2 5,4365 0,1862 0,7302 5 6,1300 0,5536 Q921K2 Poly [ADP-ribose] polymerase 1 Parp1 9 0,2459 8 6,5128 0,1864 0,2270 5 6,6529 0,9745 P05201 Aspartate aminotransferase, Got1 11 -0,2545 11 7,0662 0,1899 1,0718 10 7,1562 0,4424 cytoplasmic Q9QXT0 Protein canopy homolog 2 Cnpy2 2 -0,2991 2 5,6943 0,1921 -0,0949 3 6,2543 0,6462 B2RR82 Intersectin-2 Itsn2 2 -0,2985 2 5,8753 0,1930 NaN 0 NaN 1,0000 Q6Q899 Probable ATP-dependent RNA Ddx58 3 0,2420 3 5,9515 0,1935 NaN 0 NaN 1,0000 helicase DDX58 P49717 DNA replication licensing factor Mcm4 20 -0,2522 20 7,1370 0,1940 0,4374 11 7,0826 0,9056 MCM4 P32921 Tryptophan--tRNA ligase, Wars 11 -0,2500 14 7,0604 0,1979 2,0966 5 7,6980 0,0692 cytoplasmic Q8BFZ3 Beta-actin-like protein 2 Actbl2 19 -0,2499 8 8,9289 0,1981 -3,3185 12 9,3056 0,0000 Q8BHL5-3 Engulfment and cell motility Elmo2 2 0,2393 2 5,6930 0,1985 NaN 1 5,3179 1,0000 protein 2 Q3UW53 Protein Niban Fam129a 6 -0,2940 4 6,2852 0,1998 0,4052 3 5,8342 0,8488 Q3ULL5 Eukaryotic translation initiation Eif2s2 6 0,2381 6 6,4689 0,2008 NaN 1 6,0639 1,0000 factor 2 subunit 2 P62270 40S ribosomal protein S18 Rps18 12 0,1931 13 7,0772 0,2010 -0,0389 23 7,9273 0,6847 Q6P5E4 UDP-glucose:glycoprotein Uggt1 35 -0,2476 46 7,6534 0,2022 -0,4570 25 7,4140 0,3806 glucosyltransferase 1 Q8BZ03 Serine/threonine-protein kinase Prkd2 7 0,2363 6 6,2720 0,2040 -0,3768 4 6,3999 0,4047 D2 Q9CR67 Transmembrane protein 33 Tmem33 2 -0,2909 2 5,6504 0,2046 -0,3796 2 5,9912 0,4026 P46978 Dolichyl- Stt3a 6 -0,2898 3 6,0724 0,2063 -0,4180 7 6,8676 0,4049 diphosphooligosaccharide-- protein glycosyltransferase subunit STT3A Q6GQT9 Nodal modulator 1 Nomo1 3 -0,2893 2 5,5825 0,2072 -0,4419 2 5,7250 0,3578 D3YTN4 GTPase IMAP family member 4 Gimap4 24 -0,2446 32 7,9030 0,2079 0,1112 25 8,1253 0,8127 Q5DTH1 Ubiquitin-protein ligase E3A Ube3a 3 0,2336 2 5,6953 0,2092 -0,1114 3 6,0820 0,6305 Q8C0C7 Phenylalanine--tRNA ligase alpha Farsa 4 0,1887 3 6,6176 0,2115 0,3402 4 6,9509 0,9848 subunit Q11011 Puromycin-sensitive Npepps 13 -0,2423 12 6,7311 0,2122 0,3478 9 6,8815 0,9786 aminopeptidase D3Z2H9 Tropomyosin alpha-3 chain Tpm3-rs7 21 0,1881 31 7,6882 0,2127 1,5966 23 8,1534 0,1917 Q2EMV9 Poly [ADP-ribose] polymerase 14 Parp14 5 -0,2854 2 5,7804 0,2133 -0,3605 5 6,1137 0,4171 Q3V3R1 Monofunctional C1- Mthfd1l 21 0,1876 22 7,3291 0,2140 -0,5860 18 7,4840 0,3067 tetrahydrofolate synthase, mitochondrial Q5SXR6 Clathrin heavy chain 1 Cltc 66 -0,2401 90 8,2724 0,2163 0,0211 52 7,9356 0,7350 O08795-2 Glucosidase 2 subunit beta Prkcsh 4 -0,2394 4 6,7088 0,2177 -0,3003 6 7,0520 0,4837 Q8R016 Bleomycin hydrolase Blmh 4 -0,2389 8 6,7489 0,2187 NaN 0 NaN 1,0000 Q78PY7 Staphylococcal nuclease domain- Snd1 27 -0,2387 41 7,6780 0,2191 0,5410 21 7,3290 0,8222 containing protein 1 P60122 RuvB-like 1 Ruvbl1 8 0,1849 11 7,1810 0,2208 -0,6772 3 7,1065 0,2607 P28474 Alcohol dehydrogenase class-3 Adh5 5 0,2276 6 6,4243 0,2211 1,2443 3 6,5243 0,2194 Q9D1A2 Cytosolic non-specific dipeptidase Cndp2 7 -0,2370 11 7,1664 0,2223 1,3733 4 7,3925 0,2815

A2AAV4 Tubulin-specific chaperone D Tbcd 7 -0,2795 5 6,2716 0,2229 -0,2101 3 6,0503 0,5405 Q922I7 Polypyrimidine tract-binding Ptbp1 18 0,1837 20 7,6090 0,2237 -0,4974 10 7,8064 0,3563 protein 1 D2KHZ9 Glyceraldehyde-3-phosphate Gapdh 31 0,1835 60 8,9996 0,2243 -0,1671 111 9,3528 0,5821 dehydrogenase Q60749 KH domain-containing, RNA- Khdrbs1 7 0,1829 6 6,8515 0,2256 1,0843 5 6,8211 0,4349 binding, signal transduction- associated protein 1 D3YZZ5 Protein Tmed7 Tmed7 3 -0,2774 4 6,2406 0,2265 0,1895 4 6,4837 0,9349 Q9R190 Metastasis-associated protein Mta2 6 -0,2769 2 5,5071 0,2274 0,0404 5 6,4256 0,7798 MTA2 Q8CFI7 DNA-directed RNA polymerase II Polr2b 8 0,2233 4 6,0936 0,2300 0,0850 5 6,4016 0,8256 subunit RPB2 Q8C3J5 Dedicator of cytokinesis protein 2 Dock2 42 0,1812 45 7,5638 0,2301 -0,2573 37 7,5827 0,5144

O88569 Heterogeneous nuclear Hnrnpa2b1 17 0,1810 27 7,6354 0,2304 0,6764 30 7,8221 0,7163 ribonucleoproteins A2/B1 Q6Q477 Protein Atp2b4 Atp2b4 3 -0,2744 2 5,7516 0,2316 0,1959 2 5,8042 0,9416 B1AVD3 SAM and SH3 domain-containing Sash3 3 0,2224 2 6,5058 0,2318 2,3281 3 6,8560 0,0399 protein 3 Q3U4T8 DNA replication licensing factor Mcm7 24 -0,2315 22 7,2414 0,2332 -0,5605 35 7,7743 0,3205 MCM7 P43274 Histone H1.4 Hist1h1e 16 -0,2312 3 6,6681 0,2340 -1,8541 7 7,6446 0,0143 A2BGJ0 Peptidyl-prolyl cis-trans Ppih 4 0,2213 2 5,9657 0,2341 1,3014 2 5,8964 0,1941 isomerase Q64514-2 Tripeptidyl-peptidase 2 Tpp2 16 -0,2303 14 6,7772 0,2358 1,1627 7 6,6625 0,2597 P97311 DNA replication licensing factor Mcm6 17 -0,2299 13 6,9181 0,2366 0,5368 13 7,0604 0,8256 MCM6 P63028 Translationally-controlled tumor Tpt1 6 0,2200 6 6,5826 0,2370 1,0896 7 6,7531 0,2998 protein Q922Q8 Leucine-rich repeat-containing Lrrc59 6 -0,2708 3 6,0126 0,2378 -0,6864 7 6,8470 0,2563 protein 59 E9PXE7 40S ribosomal protein S11 Rps11 11 0,2193 4 6,5846 0,2383 -0,2112 21 7,5936 0,5485 A6H6M1 T-cell surface glycoprotein CD3 Cd3e 2 -0,2690 3 6,5383 0,2409 NaN 0 NaN 1,0000 epsilon chain Q6ZWV3 60S ribosomal protein L10 Rpl10 9 0,2165 3 6,3652 0,2445 -0,5381 21 7,2916 0,3330 B8JK30 Heterogeneous nuclear Hnrnpm 25 0,1752 29 7,5784 0,2458 -0,9691 55 7,8796 0,1461 ribonucleoprotein M I1E4X5 UPF0505 protein C16orf62 9030624J02Rik 3 -0,2655 3 5,6890 0,2471 NaN 1 5,2226 1,0000 homolog Q3TAS6 UPF0510 protein INM02 Inm02 2 -0,2650 2 5,2764 0,2480 NaN 0 NaN 1,0000 Q61029 Lamina-associated polypeptide 2, Tmpo 12 0,1743 18 7,1969 0,2482 1,6605 13 7,7762 0,1704 isoforms beta/delta/epsilon/gamma F8WGL8 FACT complex subunit SSRP1 Ssrp1 8 -0,2228 10 6,7938 0,2514 0,3210 10 6,7411 0,9311 P11031 Activated RNA polymerase II Sub1 8 0,1729 7 7,0885 0,2520 2,4127 7 6,9308 0,0323 transcriptional coactivator p15 P53994 Ras-related protein Rab-2A Rab2a 5 -0,2620 7 6,2261 0,2535 -0,1895 4 5,9836 0,5588 F8WHU5 Sister chromatid cohesion protein Pds5b 11 0,2109 6 6,2350 0,2568 0,1832 10 6,7319 0,9282 PDS5 homolog B Q9CVB6 Actin-related protein 2/3 complex Arpc2 13 0,1704 13 7,4158 0,2588 1,1255 21 7,8014 0,4104 subunit 2 P62748 Hippocalcin-like protein 1 Hpcal1 4 0,2099 3 5,9415 0,2591 0,7788 8 6,6447 0,5141 P21995 Embigin Emb 3 0,2096 4 6,0930 0,2596 -0,0179 2 6,2620 0,7211 P50247 Adenosylhomocysteinase Ahcy 21 -0,2180 13 7,3479 0,2619 -0,2581 21 7,9210 0,5138 P61290 Proteasome activator complex Psme3 5 -0,2571 7 6,3318 0,2623 1,5786 6 6,5224 0,1007 subunit 3 Q9JKR6 Hypoxia up-regulated protein 1 Hyou1 7 -0,2567 3 5,8478 0,2632 -0,6410 10 6,9255 0,2784 Q923F1 Methylosome subunit pICln Clns1a 2 -0,2563 2 5,7281 0,2639 1,0060 4 6,4122 0,3506 F8VQH5 40S ribosomal protein S19 Rps19-ps4 14 0,1684 21 7,3273 0,2645 1,9623 12 7,2448 0,0930 Q8BWY3 Eukaryotic peptide chain release Etf1 4 -0,2165 7 6,8796 0,2651 NaN 1 6,0950 1,0000 factor subunit 1 Q9CQW1 Synaptobrevin homolog YKT6 Ykt6 2 -0,2551 3 5,9129 0,2662 1,5070 2 5,7940 0,1204 Q64737 Trifunctional purine biosynthetic Gart 13 -0,2152 9 6,7281 0,2681 0,9230 8 6,8249 0,5381 protein adenosine-3 F6TJZ4 60S ribosomal protein L7a Rpl7a 10 0,1668 9 6,7523 0,2689 -0,8421 20 7,6064 0,1900 F8WJD4 Symplekin Sympk 6 0,2046 3 6,2770 0,2711 0,6554 4 6,1460 0,6172 Q9D1D4 Transmembrane emp24 domain- Tmed10 9 -0,2138 8 6,7832 0,2713 0,6348 18 7,3435 0,7485 containing protein 10 Q91VD9 NADH-ubiquinone Ndufs1 10 -0,2137 14 6,9906 0,2713 -0,8253 11 6,6461 0,1532 oxidoreductase 75 kDa subunit, mitochondrial P26040 Ezrin Ezr 29 0,1656 26 7,4326 0,2726 1,3652 18 7,2768 0,2853 P17427 AP-2 complex subunit alpha-2 Ap2a2 8 0,2031 5 6,0936 0,2746 NaN 0 NaN 1,0000 Q9D2R0 Acetoacetyl-CoA synthetase Aacs 6 -0,2500 7 6,4549 0,2758 -0,4189 8 6,5281 0,3739 O08709 Peroxiredoxin-6 Prdx6 13 -0,2116 33 7,4545 0,2761 1,4318 24 7,7235 0,2557 P57776-3 Elongation factor 1-delta Eef1d 9 0,2019 2 6,1447 0,2776 1,3432 2 6,6499 0,1769 Q99KE1 NAD-dependent malic enzyme, Me2 3 -0,2491 2 5,9686 0,2777 NaN 1 6,1879 1,0000 mitochondrial Q9D967 Magnesium-dependent Mdp1 3 0,2016 2 5,8324 0,2782 1,6021 3 5,9688 0,0948 phosphatase 1 Q01853 Transitional endoplasmic Vcp 30 -0,2106 51 7,7026 0,2785 0,6320 20 7,6033 0,7506 reticulum ATPase Q3TRJ1 Vacuolar protein sorting- Vps35 14 -0,2104 12 6,6784 0,2790 0,0812 12 7,0613 0,7866 associated protein 35 B1AXW7 Peroxiredoxin-1 Prdx1 17 -0,2103 32 8,0604 0,2790 1,1482 33 8,2481 0,3974 Q9DCL9 Multifunctional protein ADE2 Paics 8 0,1632 9 6,8267 0,2793 0,0446 3 6,5419 0,7841 Q91VA7 Isocitrate dehydrogenase 3 Idh3b 8 -0,2479 6 6,2861 0,2800 -0,4883 6 6,8335 0,3617 (NAD+) beta Q52L50 Ras-related protein Rap-1b Rap1b 8 0,1626 8 7,2631 0,2812 0,4347 12 7,4786 0,9078 Q91WN1 DnaJ homolog subfamily C Dnajc9 5 -0,2470 2 6,0736 0,2818 0,5340 6 7,3010 0,8279 member 9 Q8C2K5-2 RAS protein activator like-3 Rasal3 5 -0,2469 5 6,2047 0,2819 NaN 1 5,4623 1,0000 P43247 DNA mismatch repair protein Msh2 11 -0,2085 9 6,6956 0,2833 -0,6838 9 6,8164 0,2575 Msh2 Q6ZQI3 Malectin Mlec 6 -0,2454 8 6,4658 0,2849 -0,9667 6 6,7823 0,1061 Q3THE2 Myosin regulatory light chain 12B Myl12b 9 0,1613 11 7,2846 0,2850 0,5294 12 7,5355 0,8315

A2A881 Src kinase-associated Skap1 6 -0,2452 2 6,2325 0,2852 1,3935 3 6,5366 0,1578 phosphoprotein 1 Q8C7X2 Uncharacterized protein Kiaa0090 8 -0,2451 5 6,1246 0,2855 -0,9861 6 6,3370 0,1006 KIAA0090 Q61768 Kinesin-1 heavy chain Kif5b 9 -0,2445 5 6,2311 0,2866 0,2713 7 6,6794 0,9801 P63280 SUMO-conjugating enzyme UBC9 Ube2i 6 0,1607 10 7,0961 0,2869 1,6398 7 6,9883 0,1771

Q5SUA5 Unconventional myosin-Ig Myo1g 41 0,1605 53 7,7749 0,2873 -0,5279 37 7,7710 0,3387 Q3TML6 Eukaryotic translation initiation Eif2s3x 5 0,1975 3 6,0052 0,2881 0,2306 6 7,3435 0,9184 factor 2 subunit 3, X-linked Q9JK23 Proteasome assembly chaperone Psmg1 3 0,1967 3 5,7791 0,2900 -0,1648 4 6,1971 0,5810 1 P10300 T-cell surface glycoprotein CD8 Cd8b 3 0,1594 4 6,8800 0,2908 0,6479 6 6,9021 0,7383 beta chain P61161 Actin-related protein 2 Actr2 16 0,1591 17 7,6667 0,2916 0,6905 17 8,0073 0,7057 Q20BD0 Heterogeneous nuclear Hnrnpab 9 0,1960 6 6,2473 0,2918 0,7156 15 7,1719 0,6866 ribonucleoprotein A/B Q8BL97 Serine/arginine-rich splicing Srsf7 4 0,1590 5 6,8793 0,2920 -0,0951 6 7,4910 0,6389 factor 7 A2AC28 3-beta-hydroxysteroid- Ebp 3 -0,2413 3 6,3888 0,2930 -0,1328 6 6,9286 0,6089 Delta(8),Delta(7)-isomerase P11835 Integrin beta-2 Itgb2 23 0,1586 34 7,3550 0,2931 0,2053 21 7,5618 0,8958 F6WUK6 Protein SCAF8 Scaf8 3 0,1953 3 5,7714 0,2934 1,4880 2 5,7625 0,1262 E9QB02 Methionine--tRNA ligase, Mars 11 0,1577 11 6,6675 0,2959 -0,4418 12 7,1074 0,3899 cytoplasmic Q9Z2I8 Succinyl-CoA ligase [GDP- Suclg2 2 0,1937 3 6,0624 0,2974 NaN 1 5,9980 1,0000 forming] subunit beta, mitochondrial A5GZX3 Lactoylglutathione lyase Glo1 5 0,1928 3 6,0045 0,2996 1,4241 7 6,5557 0,1470 E9QLA0 Mitochondrial inner membrane Immt 6 0,1918 4 5,9621 0,3021 -0,6076 9 7,0188 0,2954 protein Q543K5 Phosphoserine aminotransferase Psat1 9 -0,2364 10 6,5318 0,3030 0,0756 6 6,8136 0,7818

Q3U2W2 Myb-binding protein 1A Mybbp1a 13 -0,1990 9 6,7858 0,3060 -0,3559 9 6,6600 0,4205 Q9CZD3 Glycine--tRNA ligase Gars 6 -0,2338 6 6,4914 0,3083 0,1134 4 6,3711 0,8551 Q9EPL8 Importin-7 Ipo7 5 0,1883 5 6,3547 0,3111 -0,1083 5 6,5488 0,6334 P97371 Proteasome activator complex Psme1 17 0,1524 29 7,7499 0,3124 1,5069 21 8,0290 0,2249 subunit 1 A2AA77 Succinate dehydrogenase Sdhb 10 -0,1958 13 6,8801 0,3136 -0,2294 17 7,1441 0,5349 [ubiquinone] iron-sulfur subunit, mitochondrial A2AH38 Nuclear pore complex protein Nup160 6 0,1873 2 5,5065 0,3137 -0,4761 7 6,4333 0,3346 Nup160 Q4VAA2 Protein CDV3 Cdv3 4 0,1873 4 6,2934 0,3137 NaN 1 5,9484 1,0000 A6ZI44 Fructose-bisphosphate aldolase Aldoa 21 0,1513 25 8,0968 0,3157 1,0977 15 8,0308 0,4268 Q6ZWQ9 Protein Myl12a Myl12a 8 0,1865 2 5,8072 0,3157 1,4709 2 6,2240 0,1315 P62843 40S ribosomal protein S15 Rps15 3 0,1512 3 7,2372 0,3161 0,4113 2 6,1396 0,8429 P18654 Ribosomal protein S6 kinase Rps6ka3 13 0,1859 3 6,3678 0,3173 -0,1425 21 7,4883 0,6012 alpha-3 Q61635 Protein Ifi47 Ifi47 24 0,1508 32 7,8794 0,3173 0,0667 30 7,9619 0,7741 O08583 THO complex subunit 4 Alyref 4 0,1508 7 6,7288 0,3173 1,1325 6 7,0008 0,4064 F8WH45 Leucine--tRNA ligase, cytoplasmic Lars 22 -0,1944 22 7,0083 0,3173 0,5633 12 6,8569 0,8046

A2AN08-5 E3 ubiquitin-protein ligase UBR4 Ubr4 13 -0,2295 8 6,2180 0,3173 -1,6301 2 5,5881 0,0125 P54823 Probable ATP-dependent RNA Ddx6 3 -0,2294 4 6,4785 0,3176 NaN 0 NaN 1,0000 helicase DDX6 P55264 Adenosine kinase Adk 5 0,1856 4 6,3489 0,3180 0,1779 4 6,8786 0,8714 Q6PAR5-4 GTPase-activating protein and Gapvd1 3 -0,2280 3 6,0117 0,3205 NaN 1 5,4345 1,0000 VPS9 domain-containing protein 1 Q8CDN6 Thioredoxin-like protein 1 Txnl1 3 -0,2280 3 5,9448 0,3206 0,4037 3 6,5144 0,8503 P62821 Ras-related protein Rab-1A Rab1A 10 -0,2270 9 6,4720 0,3227 0,2948 12 7,0731 0,9759 Q921T2 Torsin-1A-interacting protein 1 Tor1aip1 2 0,1837 2 6,1068 0,3229 NaN 0 NaN 1,0000 F8WIV2 Serpin B6 Serpinb6a 2 0,1836 2 5,8750 0,3233 NaN 0 NaN 1,0000 E9Q4V8 14-3-3 protein eta Ywhah 3 -0,2244 2 5,4304 0,3283 NaN 0 NaN 1,0000 A2AF47 Dedicator of cytokinesis protein Dock11 15 -0,2241 11 6,5415 0,3288 0,2707 5 6,2015 0,9806 11 P51859 Hepatoma-derived growth factor Hdgf 5 0,1813 5 6,4762 0,3293 1,2544 8 6,9089 0,3395

B2RXM7 SAP domain-containing Sarnp 8 0,1470 8 6,9266 0,3295 1,6629 8 7,2509 0,1696 ribonucleoprotein Q8QZT1 Acetyl-CoA acetyltransferase, Acat1 4 -0,1879 5 6,6524 0,3338 -0,2486 4 6,4342 0,5073 mitochondrial P51125 Calpastatin Cast 5 0,1785 6 6,4158 0,3368 0,7398 3 6,2782 0,5456 Q3TMX5 Mesencephalic astrocyte-derived Manf 4 -0,2202 2 5,7293 0,3374 -0,1621 7 6,5049 0,5835 neurotrophic factor Q7TNV0 Protein DEK Dek 3 0,1781 3 6,3423 0,3378 -0,1993 2 6,6454 0,5500 P53996 Cellular nucleic acid-binding Cnbp 2 0,1781 3 6,3561 0,3378 NaN 0 NaN 1,0000 protein Q60766 Immunity-related GTPase family Irgm1 9 0,1437 6 6,7444 0,3407 -0,3112 8 7,1372 0,4761 M protein 1 P23198 Chromobox protein homolog 3 Cbx3 10 0,1426 14 7,1472 0,3442 0,9476 20 7,3036 0,5216 Q544U7 Ras-related protein Rab-27A Rab27a 5 -0,2170 3 5,8173 0,3446 0,0390 7 6,5519 0,7784 Q8K224 N-acetyltransferase 10 Nat10 3 -0,2168 2 5,3622 0,3450 NaN 1 5,6162 1,0000 Q8VDM6 Heterogeneous nuclear Hnrnpul1 4 0,1754 4 6,1326 0,3451 0,5484 2 6,1920 0,7131 ribonucleoprotein U-like protein 1 Q3U9G9 Lamin-B receptor Lbr 9 0,1403 7 6,8021 0,3522 -1,2529 11 7,3098 0,0762 P14824 Annexin A6 Anxa6 57 0,1401 105 8,4537 0,3526 0,8319 96 8,6062 0,6013 Q52KC3 DNA replication licensing factor Mcm5 22 -0,1805 26 7,2151 0,3533 -0,3167 26 7,4985 0,4722 MCM5 Q6P5D8 Structural maintenance of Smchd1 24 -0,2126 5 6,3726 0,3545 -0,7828 21 7,0647 0,2136 chromosomes flexible hinge domain-containing protein 1 E9Q762 Structural maintenance of Smc3 25 0,1393 21 7,0527 0,3553 0,1962 14 6,8447 0,8877 chromosomes protein 3 P46467 Vacuolar protein sorting- Vps4b 2 -0,2108 2 5,6931 0,3585 0,7827 2 6,4418 0,5109 associated protein 4B Q8CIG8 Protein arginine N- Prmt5 7 0,1701 2 5,9453 0,3600 -0,1045 10 6,8021 0,6370 methyltransferase 5 Q7TMK9 Heterogeneous nuclear Syncrip 3 0,1701 2 6,0129 0,3600 -1,9770 4 6,4913 0,0031 ribonucleoprotein Q D3Z627 Integrin alpha-L Itgal 33 0,1379 42 7,9041 0,3603 0,4295 20 7,5653 0,9120 E9QPI5 Sister chromatid cohesion protein Pds5a 9 0,1376 8 6,6454 0,3612 0,0820 5 6,5827 0,8225 PDS5 homolog A Q05144 Ras-related C3 botulinum toxin Rac2 11 0,1371 20 7,6731 0,3630 1,0895 26 7,9493 0,4317 substrate 2 P62331 ADP-ribosylation factor 6 Arf6 7 -0,2077 6 6,5817 0,3656 0,0987 5 6,5878 0,8397 Q07797 Galectin-3-binding protein Lgals3bp 6 -0,2077 6 6,2630 0,3656 0,7508 5 6,3654 0,5367 Q8R379 GTPase, IMAP family member 7 Gimap7 13 0,1363 21 7,3234 0,3658 0,7321 20 7,8111 0,6742 P62835 Ras-related protein Rap-1A Rap1a 6 0,1679 2 5,8126 0,3662 0,2682 2 5,7118 0,9831 Q8BTM8 Filamin-A Flna 54 0,1362 49 7,6831 0,3662 0,1336 27 7,1663 0,8323 Q8R5L1 Complement component 1 Q C1qbp 2 -0,2065 4 6,0464 0,3684 -1,2611 4 6,3751 0,0448 subcomponent-binding protein, mitochondrial Q3UD06 ATP synthase gamma chain Atp5c1 8 -0,1748 10 7,2505 0,3687 -0,9544 15 7,6717 0,1507 F6ZJB0 Ras GTPase-activating-like protein Iqgap1 75 0,1354 94 8,1687 0,3690 0,7792 54 8,0031 0,6394 IQGAP1 Q50HX4 Ras-related protein Rab-14 Rab14 5 -0,2059 4 6,0724 0,3699 -0,4390 5 6,1067 0,3598 P68369 Tubulin alpha-1A chain Tuba1a 27 -0,1740 52 8,7441 0,3709 -2,2358 50 8,7032 0,0040 P05202 Aspartate aminotransferase, Got2 19 -0,1738 24 7,8447 0,3715 0,6085 13 8,0563 0,7689 mitochondrial Q60953 Protein PML Pml 6 0,1658 5 6,1666 0,3720 0,9880 3 6,4754 0,3622 F6XLC7 Non-POU domain-containing Nono 13 0,1345 10 7,1730 0,3722 1,6060 6 7,4835 0,1885 octamer-binding protein P27659 60S ribosomal protein L3 Rpl3 12 0,1340 7 7,0144 0,3741 -1,0134 18 7,6539 0,1327 D3YVN7 Elongation factor Tu Gm9755 9 0,1338 8 7,1522 0,3746 -0,0043 11 7,3141 0,7136 Q60932 Voltage-dependent anion- Vdac1 16 -0,1726 25 7,4844 0,3749 -0,6830 34 8,1430 0,2579 selective channel protein 1 Q640N3 Rho GTPase-activating protein 30 Arhgap30 8 0,1336 9 6,7458 0,3755 1,6271 3 6,1273 0,0889

Q9ES52 Phosphatidylinositol 3,4,5- Inpp5d 10 -0,2034 10 6,4111 0,3759 NaN 1 5,0027 1,0000 trisphosphate 5-phosphatase 1 Q9DBC3 Cap-specific mRNA (nucleoside-2- Ftsjd2 8 -0,2020 3 6,0810 0,3790 0,5946 5 6,2545 0,6710 O-)-methyltransferase 1 Q5XJY5 Coatomer subunit delta Arcn1 4 -0,1978 4 6,4121 0,3891 NaN 0 NaN 1,0000 P70398 Probable ubiquitin carboxyl- Usp9x 6 -0,1976 2 5,8523 0,3895 0,1998 4 6,0536 0,9457 terminal hydrolase FAF-X Q8VD65 Phosphoinositide 3-kinase Pik3r4 4 -0,1973 2 5,4959 0,3902 -0,4078 2 5,5555 0,3819 regulatory subunit 4 F8WJ93 Echinoderm microtubule- Eml4 4 -0,1972 4 6,2545 0,3906 NaN 1 5,7003 1,0000 associated protein-like 4 Q543N3 LIM and SH3 domain protein 1 Lasp1 3 -0,1670 7 6,6307 0,3906 1,8395 3 6,5604 0,0495 Q5M9P5 NADH dehydrogenase Ndufs8 2 -0,1970 2 5,4371 0,3911 0,0876 3 5,9312 0,8282 [ubiquinone] iron-sulfur protein 8, mitochondrial P24452 Macrophage-capping protein Capg 6 -0,1664 13 7,0395 0,3922 1,0652 7 7,2112 0,4465 Q9Z0P5 Twinfilin-2 Twf2 4 -0,1964 3 6,1677 0,3925 1,9133 4 6,7907 0,0398 Q8C2Q3 RNA-binding protein 14 Rbm14 8 0,1581 3 6,2954 0,3946 -0,3261 7 6,5250 0,4437 Q9CPY7 Cytosol aminopeptidase Lap3 5 -0,1955 2 6,1915 0,3947 0,4696 3 6,3444 0,7870 P47962 60S ribosomal protein L5 Rpl5 9 0,1279 6 6,7295 0,3960 0,3717 11 7,2089 0,9591 O35381 Acidic leucine-rich nuclear Anp32a 12 0,1276 23 7,4494 0,3969 1,5671 18 7,7002 0,2022 phosphoprotein 32 family member A Q8C4B4 Protein unc-119 homolog B Unc119b 3 0,1569 2 5,6296 0,3981 0,5412 4 6,2524 0,7198 Q9ESZ8 General transcription factor II-I Gtf2i 11 0,1568 5 6,2465 0,3985 0,0650 3 5,9818 0,8050 Q8BVI4 Dihydropteridine reductase Qdpr 4 0,1564 7 6,4823 0,3997 0,9370 6 6,5296 0,3964 Q6ZQ61 Matrin-3 Matr3 5 0,1548 7 6,3468 0,4043 0,6774 6 6,4203 0,5981 Q6PIU9 Uncharacterized protein 3 0,1547 4 6,1933 0,4047 1,2712 2 5,9487 0,2072 FLJ45252 homolog Q9D1E6 Tubulin-folding cofactor B Tbcb 2 -0,1913 3 5,5883 0,4048 NaN 0 NaN 1,0000 Q3TXT7 RuvB-like 2 Ruvbl2 10 0,1253 14 7,1615 0,4057 -0,1422 7 7,2264 0,6014 P61164 Alpha-centractin Actr1a 4 -0,1907 4 6,5063 0,4065 0,1096 3 6,3618 0,8510 Q6ZWV7 60S ribosomal protein L35 Rpl35 4 -0,1898 2 6,0774 0,4086 -0,1249 7 7,2149 0,6151 E9Q6R0 Nucleosome assembly protein 1- Nap1l4 2 -0,1891 2 5,5975 0,4104 NaN 1 6,1196 1,0000 like 4 O35955 Proteasome subunit beta type-10 Psmb10 3 0,1237 9 6,9585 0,4117 1,4556 5 6,8842 0,2456

P25206 DNA replication licensing factor Mcm3 24 -0,1594 30 7,3609 0,4126 1,1000 21 7,4023 0,4254 MCM3 Q3TQX5 ATP-dependent RNA helicase Ddx3x 9 -0,1593 10 6,7411 0,4130 -0,5865 8 6,7783 0,2664 DDX3X P42227 Signal transducer and activator of Stat3 14 0,1517 10 6,5975 0,4138 -0,3811 18 7,2469 0,4288 transcription 3 Q3UBX0 Transmembrane protein 109 Tmem109 3 0,1515 2 6,3407 0,4146 0,8442 3 6,5608 0,4633 Q80U93 Nuclear pore complex protein Nup214 3 -0,1874 4 6,1674 0,4146 NaN 0 NaN 1,0000 Nup214 Q9JIA6 Galactokinase Galk1 5 0,1225 6 6,6954 0,4162 -2,3442 4 7,3453 0,0027 B1AWD9 Clathrin light chain A Clta 2 -0,1866 3 6,2005 0,4166 NaN 0 NaN 1,0000 Q9R0Q7 Prostaglandin E synthase 3 Ptges3 3 0,1222 6 6,9057 0,4172 0,7916 5 6,7139 0,5039 B2RQC6 Carbamoyl-phosphate synthetase Cad 39 -0,1577 43 7,6685 0,4177 0,7839 32 7,4168 0,6359 2, aspartate transcarbamylase, and dihydroorotase

A1A4T2 Neutral alpha-glucosidase AB Ganab 30 -0,1574 41 7,7650 0,4187 -0,7970 31 7,7769 0,2078 F8WGC2 Annexin Anxa7 9 -0,1566 11 6,9286 0,4210 0,8803 7 6,8726 0,5673 Q8BK67 Protein RCC2 Rcc2 14 -0,1561 17 7,2803 0,4224 0,2545 10 7,5272 0,9398 Q8R050 Eukaryotic peptide chain release Gspt1 7 -0,1552 6 6,8213 0,4251 0,3086 7 6,8714 0,9883 factor GTP-binding subunit ERF3A

P35279 Ras-related protein Rab-6A Rab6a 4 0,1477 2 5,2704 0,4262 0,0369 3 5,9941 0,7762 B1B0W8 Hypoxanthine-guanine Hprt 7 0,1196 8 6,9202 0,4273 1,5742 12 7,1882 0,1997 phosphoribosyltransferase Q9JHJ0 Tropomodulin-3 Tmod3 4 -0,1824 6 6,3536 0,4273 -0,0055 2 6,2127 0,7335 P70268-2 Serine/threonine-protein kinase Pkn1 6 0,1464 6 6,1969 0,4303 0,4458 3 6,2448 0,8097 N1 O89100 GRB2-related adaptor protein 2 Grap2 5 -0,1802 6 6,4960 0,4330 1,6015 7 6,6264 0,0950 B2RX66 Serine/threonine-protein kinase Taok1 2 -0,1802 2 5,6165 0,4330 NaN 0 NaN 1,0000 TAO1 Q9D662 Protein transport protein Sec23B Sec23b 7 -0,1798 5 5,9936 0,4340 1,0605 3 6,1734 0,3169

Q64012 RNA-binding protein Raly Raly 5 -0,1781 2 5,5977 0,4384 -0,4627 6 6,4335 0,3436 Q3U0T9 Ras-related protein Rab-35 Rab35 5 -0,1778 4 6,2453 0,4391 0,2365 8 6,8503 0,9236 Q8C266 Ras-related protein Rab-5C Rab5c 7 -0,1774 13 6,5009 0,4402 0,2231 10 7,2084 0,9116 P35980 60S ribosomal protein L18 Rpl18 11 0,1161 8 7,1176 0,4407 0,1909 28 7,7981 0,8830 E9Q9F5 Septin-7 Sept7 7 -0,1491 12 7,3703 0,4435 0,8966 5 7,0637 0,5560 P01851 T-cell receptor beta-2 chain C 2 0,1414 2 6,4611 0,4460 -0,1224 4 6,7856 0,6202 region O70172 Phosphatidylinositol 5-phosphate Pip4k2a 2 -0,1744 2 5,9944 0,4480 NaN 0 NaN 1,0000 4-kinase type-2 alpha F8WJE0 SAM domain and HD domain- Samhd1 36 0,1136 48 8,0747 0,4506 0,6576 55 8,2298 0,7308 containing protein 1 P01731 T-cell surface glycoprotein CD8 Cd8a 4 -0,1731 3 6,0541 0,4513 0,0559 2 6,5305 0,7956 alpha chain Q58E59 Splicing factor 3A subunit 3 Sf3a3 6 -0,1730 4 6,3173 0,4517 0,9650 4 6,4718 0,3774 Q8BRN9 Coiled-coil and C2 domain- Cc2d1b 4 -0,1728 2 5,4702 0,4521 1,1652 2 5,5002 0,2583 containing protein 1B Q8BY87 Ubiquitin carboxyl-terminal Usp47 3 -0,1728 2 5,5028 0,4522 NaN 0 NaN 1,0000 hydrolase 47 Q564E5 Eukaryotic translation initiation Eif4h 6 -0,1723 6 6,5190 0,4535 2,3793 3 6,4137 0,0085 factor 4H P01831 Thy-1 membrane glycoprotein Thy1 7 -0,1459 19 8,0461 0,4536 0,8511 27 8,1464 0,5877 Q9DCT2 NADH dehydrogenase Ndufs3 5 -0,1717 2 5,6734 0,4551 -0,4534 7 6,5298 0,3499 [ubiquinone] iron-sulfur protein 3, mitochondrial E9QJS2 Phosphoserine phosphatase Psph 7 0,1386 3 6,0400 0,4552 2,0721 7 6,7843 0,0243 P30681 High mobility group protein B2 Hmgb2 22 0,1118 43 8,3653 0,4575 1,2626 55 8,4318 0,3353 P62715 Serine/threonine-protein Ppp2cb 4 -0,1445 6 6,6553 0,4580 0,8199 4 6,7635 0,4818 phosphatase 2A catalytic subunit beta isoform E9Q0K1 Transmembrane 9 superfamily Tm9sf2 2 0,1370 3 6,1387 0,4603 NaN 1 6,1530 1,0000 member 2 H3BKH6 S-formylglutathione hydrolase Esd 8 -0,1434 12 6,9324 0,4614 0,3650 8 7,3067 0,9645 P10126 Elongation factor 1-alpha 1 Eef1a1 22 0,1106 40 8,6927 0,4623 -0,4910 50 8,9376 0,3601 E9Q481 Serine/threonine-protein Smek1 3 -0,1689 3 5,7293 0,4625 -0,9072 4 6,7753 0,1243 phosphatase 4 regulatory subunit 3A P27773 Protein disulfide-isomerase A3 Pdia3 29 -0,1429 38 7,8231 0,4629 -0,0585 30 8,4131 0,6686 E9Q1E9 Structural maintenance of Smc2 18 -0,1425 12 6,9785 0,4642 -0,3080 10 6,5043 0,4582 chromosomes protein G3X8V1 Protein-tyrosine kinase 2-beta Ptk2b 3 -0,1679 2 5,9449 0,4652 0,6433 3 5,9819 0,6277 A2ATK1 5-3 exoribonuclease 2 Xrn2 5 0,1353 3 5,9434 0,4659 -0,3651 5 6,2031 0,4135 E9QM21 Bcl-2 homologous Bak1 5 -0,1671 6 6,2652 0,4673 -0,3553 8 6,5281 0,4210 antagonist/killer P42208 Septin-2 Sept2 6 -0,1410 8 6,8185 0,4688 0,8100 4 6,4607 0,4895 Q3UG25 Nuclear factor NF-kappa-B p100 Nfkb2 3 0,1330 3 6,1520 0,4733 -0,0168 2 5,8242 0,7223 subunit E9Q7G0 Protein Numa1 Numa1 27 0,1078 18 6,9062 0,4737 0,3300 27 7,0356 0,9931 P48036 Annexin A5 Anxa5 14 0,1078 14 7,2185 0,4737 1,5949 17 7,6884 0,1923 Q9JK81 UPF0160 protein MYG1, Myg1 4 0,1321 7 6,4311 0,4763 0,7134 3 6,7945 0,5675 mitochondrial Q9Z1R2 Large proline-rich protein BAG6 Bag6 3 0,1316 2 5,8673 0,4780 NaN 0 NaN 1,0000 O89053 Coronin-1A Coro1a 25 0,1068 35 8,5382 0,4781 0,5576 28 8,6439 0,8091 Q3U111 Radixin Rdx 16 0,1068 5 7,1012 0,4781 2,1698 3 6,4562 0,0177 P99024 Tubulin beta-5 chain Tubb5 26 -0,1372 58 8,5626 0,4812 -0,3594 34 8,8685 0,4431 H9H9T1 Protein FAM107B Fam107b 4 0,1299 2 5,9250 0,4838 2,8363 4 6,2816 0,0014 Q9JMA1 Ubiquitin carboxyl-terminal Usp14 3 -0,1605 3 6,3173 0,4851 NaN 0 NaN 1,0000 hydrolase 14 Q9ERU9 E3 SUMO-protein ligase RanBP2 Ranbp2 7 -0,1600 2 5,6537 0,4865 0,3194 4 6,0820 0,9327 Q61753 D-3-phosphoglycerate Phgdh 11 -0,1354 16 7,7103 0,4868 0,5637 10 7,8732 0,8042 dehydrogenase D3YWP3 60S ribosomal protein L23a Rpl23a-ps3 4 0,1287 6 6,5728 0,4877 -0,1672 10 7,2281 0,5820 Q9D1M0 Protein SEC13 homolog Sec13 2 0,1287 4 5,9832 0,4877 NaN 1 6,0757 1,0000 P57780 Alpha-actinin-4 Actn4 53 0,1042 81 8,1448 0,4885 0,9385 37 7,8903 0,5276 B2KF41 Serine/arginine-rich splicing Srsf3 6 0,1042 7 7,1158 0,4885 0,4036 15 7,6026 0,9331 factor 3 P08113 Endoplasmin Hsp90b1 27 -0,1347 22 7,5904 0,4890 -0,9081 25 7,8572 0,1661 E9Q0E4 Protein NipSnap homolog 1 Nipsnap1 4 -0,1589 6 6,2328 0,4896 -0,3845 4 6,5694 0,3990 Q9JHW2 Omega-amidase NIT2 Nit2 2 -0,1588 3 5,6339 0,4898 NaN 0 NaN 1,0000 Q99PV0 Pre-mRNA-processing-splicing Prpf8 70 -0,1344 49 7,6954 0,4900 -1,0249 73 7,8054 0,1294 factor 8 Q3UVK0 Endoplasmic reticulum Ermp1 4 -0,1587 3 5,7406 0,4901 -0,8439 2 5,7889 0,1462 metallopeptidase 1 Q544R5 TAR DNA-binding protein 43 Tardbp 9 0,1038 10 7,1558 0,4902 1,1250 8 7,2759 0,4107 P15532 Nucleoside diphosphate kinase A Nme1 10 -0,1339 7 6,9980 0,4916 1,2103 3 6,7819 0,2356

P09405 Nucleolin Ncl 39 0,1034 62 7,9993 0,4919 0,1708 66 8,3827 0,8652 P63325 40S ribosomal protein S10 Rps10 12 0,1034 15 7,3252 0,4919 1,0782 16 7,4315 0,4385 D3YTS1 Signal peptidase complex Sec11a 7 -0,1580 5 6,5438 0,4919 -0,1659 10 7,0096 0,5830 catalytic subunit SEC11A Q923D5 WW domain-binding protein 11 Wbp11 2 -0,1579 3 5,9066 0,4924 NaN 0 NaN 1,0000 E9Q696 Proto-oncogene tyrosine-protein Lck 13 0,1033 22 7,3844 0,4924 0,0535 10 7,7276 0,7627 kinase LCK Q7TMF3 NADH dehydrogenase Ndufa12 2 -0,1577 2 5,5431 0,4927 1,4276 2 6,1147 0,1458 [ubiquinone] 1 alpha subcomplex subunit 12 O54988 STE20-like serine/threonine- Slk 3 -0,1569 2 5,5294 0,4949 NaN 0 NaN 1,0000 protein kinase Q499X7 Coronin-1C Coro1c 6 0,1264 4 6,5681 0,4953 -1,0176 2 6,6618 0,0923 A2AMN4 Selenide, water dikinase 1 Sephs1 5 0,1023 5 6,6320 0,4963 0,8470 2 6,3398 0,4613 Q91ZW3 SWI/SNF-related matrix- Smarca5 11 0,1260 7 6,3001 0,4966 -1,0376 9 6,7545 0,0872 associated actin-dependent regulator of chromatin subfamily A member 5 E9PWG6 Protein Ncapg Ncapg 6 -0,1562 5 6,0273 0,4969 -0,6723 5 6,2243 0,2204 Q9JLI8 Squamous cell carcinoma antigen Sart3 5 0,1259 4 6,0869 0,4971 NaN 1 5,8656 1,0000 recognized by T-cells 3 P80318 T-complex protein 1 subunit Cct3 12 0,1021 13 7,0588 0,4975 1,0584 9 7,4339 0,4506 gamma P51660 Peroxisomal multifunctional Hsd17b4 3 -0,1557 2 5,3846 0,4983 0,5996 3 6,0420 0,6665 enzyme type 2 P19096 Fatty acid synthase Fasn 59 -0,1313 46 7,6637 0,5001 0,0322 44 7,5847 0,7445 P50431 Serine hydroxymethyltransferase, Shmt1 4 -0,1313 6 6,6642 0,5002 NaN 0 NaN 1,0000 cytosolic

P17710 Hexokinase-1 Hk1 31 0,1014 33 7,5974 0,5003 -0,6958 16 7,4265 0,2519 O35286 Putative pre-mRNA-splicing factor Dhx15 23 -0,1310 16 6,9404 0,5012 -0,4237 26 7,4948 0,4013 ATP-dependent RNA helicase DHX15 P47226 Testin Tes 2 0,1004 4 6,6257 0,5042 0,1745 2 6,3043 0,9191 Q60864 Stress-induced-phosphoprotein 1 Stip1 8 0,1003 5 6,6963 0,5048 1,5569 4 7,0165 0,2059

Q8BH74 Nuclear pore complex protein Nup107 8 0,1229 5 6,1575 0,5075 -0,7913 4 6,1639 0,1666 Nup107 A2APF7 Z-DNA-binding protein 1 Zbp1 2 0,1227 3 6,2524 0,5079 -0,7730 3 6,4083 0,1741 Q4VBE8 WD repeat-containing protein 18 Wdr18 2 -0,1522 2 5,8029 0,5081 NaN 1 5,7727 1,0000

P62827 GTP-binding nuclear protein Ran Ran 17 0,0994 21 8,0062 0,5088 1,2629 32 8,3153 0,3351 P63038 60 kDa heat shock protein, Hspd1 39 -0,1279 54 8,1335 0,5114 -0,4185 40 8,7576 0,4045 mitochondrial Q3V214 DNA-directed RNA polymerases I, Polr2e 3 0,1215 3 5,9234 0,5120 0,1193 5 6,2856 0,8612 II, and III subunit RPABC1 Q9CSU0 Regulation of nuclear pre-mRNA Rprd1b 5 0,1211 2 5,9280 0,5134 0,4457 7 6,5820 0,8098 domain-containing protein 1B Q64105 Sepiapterin reductase Spr 8 0,1210 10 6,4915 0,5139 0,9318 11 6,8927 0,5321 E9PXY8 Ubiquitin carboxyl-terminal Usp7 3 -0,1489 2 5,8805 0,5175 NaN 0 NaN 1,0000 hydrolase Q08024-2 Core-binding factor subunit beta Cbfb 3 0,1200 5 6,3998 0,5175 0,9853 11 6,7129 0,3640 Q8VI75 Importin-4 Ipo4 2 0,1198 2 5,4962 0,5180 NaN 1 5,5291 1,0000 Q91YI0 Argininosuccinate lyase Asl 4 -0,1482 2 5,8664 0,5195 NaN 1 5,8087 1,0000 Q5SSL4-2 Active breakpoint cluster region- Abr 4 0,1193 2 5,7077 0,5198 0,1230 4 6,1866 0,8650 related protein P49710 Hematopoietic lineage cell- Hcls1 10 -0,1246 7 7,2106 0,5225 0,9910 14 7,2064 0,4931 specific protein P80314 T-complex protein 1 subunit beta Cct2 15 0,0959 13 7,3197 0,5237 0,4496 9 7,8249 0,8957

Q61598 Rab GDP dissociation inhibitor Gdi2 24 -0,1241 30 7,8760 0,5243 1,0846 26 7,7334 0,4347 beta Q8K2H4 Arf-GAP with coiled-coil, ANK Acap1 6 0,1177 4 6,2146 0,5254 -0,0862 8 6,5268 0,6545 repeat and PH domain-containing protein 1 P14733 Lamin-B1 Lmnb1 31 -0,1235 22 7,2426 0,5264 -0,1454 25 7,5598 0,5989 Q3UCF2 Cell division cycle 5-like protein Cdc5l 2 0,1169 3 5,8794 0,5282 NaN 1 5,4094 1,0000 Q6P9R2 Serine/threonine-protein kinase Oxsr1 3 0,1166 3 5,8085 0,5291 NaN 1 5,9221 1,0000 OSR1 P62918 60S ribosomal protein L8 Rpl8 6 -0,1444 4 6,5213 0,5302 -0,6896 11 7,2946 0,2548 A2AL35 Gelsolin Gsn 12 -0,1442 3 6,3048 0,5307 -3,1660 4 7,7576 0,0001 Q3UVN5 NSFL1 cofactor p47 Nsfl1c 8 0,1160 5 6,5898 0,5314 1,2518 8 6,8869 0,3409 P41241 Tyrosine-protein kinase CSK Csk 5 0,0940 5 6,6894 0,5319 0,7133 5 6,5744 0,5676 Q6NV83 U2 snRNP-associated SURP motif- U2surp 4 -0,1436 4 5,9362 0,5324 NaN 1 5,2674 1,0000 containing protein Q6P542 ATP-binding cassette sub-family F Abcf1 4 -0,1436 3 5,9708 0,5325 NaN 1 5,4531 1,0000 member 1 A2A5N2 14-3-3 protein beta/alpha Ywhab 20 0,0936 8 6,9450 0,5336 1,1204 11 7,7383 0,4134 Q9JM76 Actin-related protein 2/3 complex Arpc3 6 0,0936 7 7,0744 0,5336 0,8242 9 7,6710 0,6068 subunit 3 Q9QYJ0 DnaJ homolog subfamily A Dnaja2 3 0,1146 2 6,2512 0,5361 -0,9323 2 6,8769 0,1579 member 2 E9Q8Q3 Dedicator of cytokinesis protein Dock10 13 0,1144 6 6,3579 0,5371 0,5936 11 6,5458 0,6719 10 Q91WJ8-2 Far upstream element-binding Fubp1 11 0,0926 10 6,9798 0,5377 1,3472 9 6,9951 0,2937 protein 1 P54923 [Protein ADP-ribosylarginine] Adprh 6 0,1140 4 6,1128 0,5385 0,8008 6 6,7496 0,4967 hydrolase A2A4J8 Vacuolar protein-sorting- Vps25 3 -0,1404 3 5,8795 0,5419 1,2327 2 5,8775 0,2248 associated protein 25 Q5EBP9 Transcription intermediary factor Trim28 21 0,0907 36 7,2601 0,5460 0,9899 13 7,3271 0,4938 1-beta P14685 26S proteasome non-ATPase Psmd3 10 -0,1176 8 6,9216 0,5464 0,2076 7 7,4643 0,8979 regulatory subunit 3 Q91YR7 Pre-mRNA-processing factor 6 Prpf6 5 -0,1386 6 6,5566 0,5469 NaN 1 5,8999 1,0000 Q3UPK6 Proteasome subunit alpha type Psma5 9 -0,1172 11 7,2927 0,5478 0,8458 13 7,3511 0,5915 Q8BWT1 3-ketoacyl-CoA thiolase, Acaa2 6 -0,1170 6 6,7580 0,5485 0,0930 6 7,1971 0,7969 mitochondrial Q6ZQG1 MCG21756, isoform CRA_a Nup205 23 0,1108 8 6,5911 0,5499 -0,7245 22 6,9625 0,2387 Q6PDG5 SWI/SNF complex subunit Smarcc2 12 0,0895 12 6,8465 0,5514 1,0079 12 6,7523 0,3494 SMARCC2 Q60668 Heterogeneous nuclear Hnrnpd 8 0,0894 10 6,9948 0,5520 0,2984 7 7,2720 0,9792 ribonucleoprotein D0 O08553 Dihydropyrimidinase-related Dpysl2 8 -0,1159 7 6,6512 0,5522 1,2111 5 6,9946 0,3624 protein 2 D3YYI8 Histone deacetylase Gm10093 5 0,0890 5 6,7828 0,5538 NaN 1 5,6201 1,0000 P29341 Polyadenylate-binding protein 1 Pabpc1 13 -0,1154 17 7,2413 0,5539 0,2297 16 7,2150 0,9176 P07901 Heat shock protein HSP 90-alpha Hsp90aa1 52 0,0887 44 7,9480 0,5550 0,6680 55 8,5432 0,7228

Q9WTP6 Adenylate kinase 2, mitochondrial Ak2 8 -0,1146 12 6,7777 0,5566 1,5514 7 6,7518 0,1079

Q9CZN7 Serine hydroxymethyltransferase Shmt2 10 -0,1145 12 7,3182 0,5572 -0,2132 3 7,1814 0,5470

Q91VH6 Protein MEMO1 Memo1 2 0,1086 2 5,6420 0,5575 NaN 0 NaN 1,0000 Q6A0C7 Ras-related protein Rab-21 Rab21 5 -0,1346 3 5,8665 0,5588 0,0119 6 6,1344 0,7510 A3KGQ6 Actin-related protein 2/3 complex Arpc5l 2 0,1081 2 6,1797 0,5595 1,9349 2 6,0577 0,0373 subunit 5 P70388 DNA repair protein RAD50 Rad50 6 -0,1342 6 6,1950 0,5600 NaN 0 NaN 1,0000 Q8C2Q7 Heterogeneous nuclear Hnrnph1 8 0,0875 6 6,7458 0,5604 -1,2035 2 6,9881 0,0859 ribonucleoprotein H P61082 NEDD8-conjugating enzyme Ube2m 2 0,1076 3 6,0714 0,5614 NaN 0 NaN 1,0000 Ubc12 Q9CPW4 Actin-related protein 2/3 complex Arpc5 8 0,0871 12 7,2592 0,5622 2,2069 15 7,2935 0,0536 subunit 5 F6VWT4 60S ribosomal protein L17 Gm10362 6 0,1068 2 5,5702 0,5643 -1,2634 13 6,8512 0,0743 Q91V64 Isochorismatase domain- Isoc1 6 0,1068 4 5,9037 0,5643 1,4287 7 6,6247 0,1454 containing protein 1 A2AG61 SH3 domain-containing kinase- Sh3kbp1 9 0,0858 9 6,8768 0,5676 1,3640 9 6,8267 0,2858 binding protein 1 Q9Z0H4-9 CUGBP Elav-like family member 2 Celf2 5 0,0857 5 6,8292 0,5683 0,4362 6 7,0319 0,9066

O88958 Glucosamine-6-phosphate Gnpda1 7 -0,1109 10 6,6625 0,5696 NaN 0 NaN 1,0000 isomerase 1 D3Z0M9 Protein Ddx23 Ddx23 12 0,0853 10 6,6228 0,5701 0,2068 8 6,6648 0,9531 Q99KQ4 Nicotinamide Nampt 4 0,1050 3 6,1743 0,5706 NaN 0 NaN 1,0000 phosphoribosyltransferase P62911 60S ribosomal protein L32 Rpl32 6 0,0852 2 6,8176 0,5707 -0,3059 10 7,0663 0,4798 Q60737 Casein kinase II subunit alpha Csnk2a1 6 -0,1302 4 6,4128 0,5718 -0,4395 7 6,9632 0,3913 Q9JK38 Glucosamine 6-phosphate N- Gnpnat1 3 0,1046 2 5,6585 0,5721 -0,1200 4 6,3170 0,6224 acetyltransferase Q8BFY9 Transportin-1 Tnpo1 9 0,1041 9 6,5873 0,5740 0,4729 5 6,6783 0,7839 E9Q386 T-cell surface glycoprotein CD3 Cd3g 2 -0,1293 2 5,9649 0,5745 0,7066 2 6,1466 0,5732 gamma chain Q6PB66 Leucine-rich PPR motif-containing Lrpprc 20 -0,1084 19 6,8279 0,5784 -0,3583 12 6,6373 0,4187 protein, mitochondrial

P97807 Fumarate hydratase, Fh 7 -0,1084 6 6,7800 0,5784 0,4421 7 6,7106 0,8133 mitochondrial P27870 Proto-oncogene vav Vav1 10 0,1029 6 6,3001 0,5785 -0,1545 10 6,9941 0,5919 P25799 Nuclear factor NF-kappa-B p105 Nfkb1 5 0,1027 4 6,2667 0,5789 -0,3308 5 6,5280 0,4400 subunit Q8BML9 Glutaminyl-tRNA synthetase Qars 9 0,0831 11 6,6851 0,5799 -0,0762 10 6,9326 0,6542 Q5EBP8 Heterogeneous nuclear Hnrnpa1 6 0,1017 5 5,9958 0,5829 0,3657 6 6,7183 0,8873 ribonucleoprotein A1 F6WMJ3 Rho guanine nucleotide exchange Arhgef6 4 0,1017 3 5,8592 0,5829 0,4575 5 6,4901 0,7985 factor 6 G3UXW9 COP9 signalosome complex Gps1 3 0,1017 4 6,2759 0,5829 NaN 0 NaN 1,0000 subunit 1 Q3UYV9 Nuclear cap-binding protein Ncbp1 8 -0,1259 7 6,4130 0,5846 -0,2726 9 6,7779 0,4871 subunit 1 P09103 Protein disulfide-isomerase P4hb 11 -0,1065 6 6,6973 0,5852 -0,4754 12 7,6222 0,3694 Q8VEK3 Heterogeneous nuclear Hnrnpu 25 0,0819 43 7,9079 0,5854 -0,9025 51 8,2125 0,1680 ribonucleoprotein U P48962 ADP/ATP translocase 1 Slc25a4 20 -0,1064 7 6,8101 0,5856 -0,5587 7 7,2397 0,3215 F8WI94 Sarcoplasmic/endoplasmic Atp2a2 4 -0,1249 3 5,8704 0,5875 -1,6112 4 6,2224 0,0135 reticulum calcium ATPase 2 P08249 Malate dehydrogenase, Mdh2 20 -0,1058 27 7,8546 0,5877 0,6625 33 8,1139 0,7271 mitochondrial B1AU75 Nuclear autoantigenic sperm Nasp 4 -0,1048 3 6,6939 0,5913 2,0244 2 6,3681 0,0283 protein Q3U4Z7 Vigilin Hdlbp 5 0,0802 2 7,2749 0,5929 0,0883 2 5,6797 0,8290 P97855 Ras GTPase-activating protein- G3bp1 3 -0,1229 4 6,3931 0,5936 0,1759 2 6,5719 0,9206 binding protein 1 B9EIE9 Adenylosuccinate synthetase Adss 2 0,0987 3 6,1311 0,5938 NaN 0 NaN 1,0000 Q9D6R2 Isocitrate dehydrogenase [NAD] Idh3a 6 -0,1037 6 6,6151 0,5951 -0,1495 8 7,1746 0,5958 subunit alpha, mitochondrial Q8VDP3 Protein-methionine sulfoxide Mical1 8 0,0983 8 6,5618 0,5953 0,6766 3 6,2913 0,5988 oxidase MICAL1 Q8BH80 Vesicle-associated membrane Vapb 3 0,0982 3 5,5117 0,5958 NaN 1 5,4364 1,0000 protein-associated protein B Q9DCH4 Eukaryotic translation initiation Eif3f 6 0,0980 6 6,5526 0,5963 0,5093 5 6,7429 0,7495 factor 3 subunit F Q9CU62 Structural maintenance of Smc1a 22 0,0794 16 6,7453 0,5966 0,2150 9 6,6365 0,9618 chromosomes protein 1A Q9JKB1 Ubiquitin carboxyl-terminal Uchl3 5 -0,1216 5 6,2291 0,5976 1,5949 6 6,4084 0,0966 hydrolase isozyme L3 P13439 Uridine 5-monophosphate Umps 5 0,0975 2 6,1107 0,5983 -0,3641 4 6,7741 0,4143 synthase F8WHL2 Coatomer subunit alpha Copa 21 0,0787 25 7,3403 0,5997 0,9333 12 7,0242 0,5311 P61255 60S ribosomal protein L26 Rpl26 6 0,0971 2 6,0368 0,5998 -0,5382 9 7,3372 0,3329 E9PYV9 Flap endonuclease 1 Fen1 10 -0,1022 8 7,0073 0,6005 -0,0083 7 7,1081 0,7103 A2AQW5 Pre-mRNA-processing factor 40 Prpf40a 7 0,0783 8 6,7404 0,6016 0,8286 3 6,4274 0,4752 homolog A Q6P8X1 Sorting nexin-6 Snx6 2 0,0965 2 5,7462 0,6018 -0,0795 2 6,0298 0,6608 P97355 Spermine synthase Sms 2 -0,1202 2 5,5746 0,6019 NaN 0 NaN 1,0000 Q4VAE6 Transforming protein RhoA Rhoa 9 0,0778 17 7,1860 0,6041 1,0126 9 6,9737 0,4792 Q5SWD9 Pre-rRNA-processing protein Tsr1 2 0,0956 2 5,3245 0,6054 NaN 0 NaN 1,0000 TSR1 homolog Q7TT37 Elongator complex protein 1 Ikbkap 5 -0,1183 3 6,0873 0,6075 0,4899 3 6,0197 0,7678 Q4FZK2 Elongation factor 1-gamma Eef1g 17 0,0770 25 8,0762 0,6079 0,4185 21 8,1458 0,9210 Q9WUP7 Ubiquitin carboxyl-terminal Uchl5 3 0,0948 2 6,0367 0,6084 0,7709 3 6,3782 0,5204 hydrolase isozyme L5 E9Q5P4 Coatomer subunit gamma Copg 7 -0,1180 6 6,3504 0,6086 -0,0196 6 6,6689 0,7195 P55258 Ras-related protein Rab-8A Rab8a 8 0,0766 10 6,7785 0,6098 0,1569 22 7,0650 0,8529 Q9QZQ8 Core histone macro-H2A.1 H2afy 13 -0,0995 10 6,8158 0,6101 -1,6746 14 7,6465 0,0246 Q9CQN1 Heat shock protein 75 kDa, Trap1 13 -0,0994 16 6,9236 0,6108 0,2711 17 6,9457 0,9546 mitochondrial E9Q9A7 Translocon-associated protein Ssr1 2 -0,1158 2 5,9632 0,6154 -0,4672 2 6,2292 0,3405 subunit alpha P14148 60S ribosomal protein L7 Rpl7 15 -0,1157 7 6,3732 0,6156 -0,8245 19 7,9433 0,1968 Q790I0 Valine--tRNA ligase Vars 46 0,0745 56 8,0660 0,6193 0,5643 37 7,7244 0,8037 Q9Z2W0 Aspartyl aminopeptidase Dnpep 3 -0,1144 3 6,0934 0,6196 0,8554 2 6,1531 0,4550 Q8QZV3 Enoyl-CoA delta isomerase 1, Eci1 4 0,0917 5 6,0846 0,6201 0,2695 3 5,9940 0,9818 mitochondrial D3Z6Q9 Bridging integrator 2 Bin2 6 0,0742 10 6,7242 0,6206 0,8643 6 6,5958 0,4484 O54824 Pro-interleukin-16 Il16 11 0,0735 17 7,0879 0,6238 1,5431 12 6,9937 0,2110 P46460 Vesicle-fusing ATPase Nsf 4 0,0898 4 6,4510 0,6273 0,2603 4 6,4985 0,9909 P20152 Vimentin Vim 13 0,0726 8 6,8837 0,6283 -1,5893 9 7,5089 0,0314 P54276 DNA mismatch repair protein Msh6 17 -0,0945 16 6,8264 0,6285 0,5317 7 6,5055 0,7286 Msh6 Q8BU30 Isoleucine--tRNA ligase, Iars 28 -0,0945 33 7,3683 0,6286 -0,1143 16 7,1375 0,6235 cytoplasmic B2RTM0 Histone H4 Gm11275 9 -0,0943 28 7,5846 0,6293 -1,5015 61 8,4392 0,0401 Q9CQD4 Charged multivesicular body Chmp1b2 2 0,0891 2 5,4886 0,6298 -0,5025 2 5,8366 0,3173 protein 1b-2 P61327 Protein mago nashi homolog Magoh 3 0,0888 3 6,0789 0,6309 -0,2278 3 6,2258 0,5251 Q8R1B4 Eukaryotic translation initiation Eif3c 14 -0,0937 19 7,2532 0,6315 0,4108 13 7,2191 0,9272 factor 3 subunit C P51881 ADP/ATP translocase 2 Slc25a5 30 -0,0936 53 8,1075 0,6319 -0,9584 52 8,5187 0,1494 P28076 Proteasome subunit beta type-9 Psmb9 4 0,0718 6 6,6782 0,6321 1,2470 5 6,8015 0,2182 A2AWQ5 Phosphorylase Pygb 20 0,0712 18 6,8723 0,6347 0,4917 16 7,2354 0,8617 E9PYH8 Histone-binding protein RBBP4 Rbbp4 3 -0,0927 7 6,8268 0,6349 0,3561 4 6,7388 0,8966 P80315 T-complex protein 1 subunit delta Cct4 21 0,0705 30 7,6411 0,6379 0,4408 13 7,6725 0,9028

P32067 Lupus La protein homolog Ssb 10 -0,0919 11 7,0766 0,6382 -0,0946 10 7,1774 0,6393 P62259 14-3-3 protein epsilon Ywhae 18 -0,0917 24 7,7286 0,6388 1,5484 25 7,9203 0,2091 Q07813 Apoptosis regulator BAX Bax 6 -0,1082 6 6,5191 0,6390 0,7005 10 7,1746 0,6980 Q61599 Rho GDP-dissociation inhibitor 2 Arhgdib 17 0,0701 22 7,6523 0,6399 2,5001 25 7,9762 0,0257 P54775 26S protease regulatory subunit Psmc4 9 -0,1077 7 6,5855 0,6405 0,5457 4 6,7272 0,7157 6B Q99JX4 Eukaryotic translation initiation Eif3m 9 -0,1076 4 6,1335 0,6407 0,2534 7 6,8075 0,9388 factor 3 subunit M Q810A7 ATP-dependent RNA helicase Ddx42 7 -0,1076 5 6,0815 0,6408 0,9720 2 5,7834 0,3727 DDX42 Q8BGD9 Eukaryotic translation initiation Eif4b 5 -0,0911 7 6,9223 0,6410 1,3776 5 6,2819 0,1636 factor 4B P62082 40S ribosomal protein S7 Rps7 12 0,0697 5 6,9709 0,6418 -0,6442 19 7,6234 0,2767 E9Q4T6 U1 small nuclear Snrpa 4 -0,1072 3 6,4176 0,6419 1,0807 3 6,7253 0,3050 ribonucleoprotein A Q3UHJ0 AP2-associated protein kinase 1 Aak1 3 0,0857 2 5,9242 0,6428 NaN 1 5,5333 1,0000 Q8R1M2 Histone H2A.J H2afj 8 -0,0905 27 8,4853 0,6430 -1,3714 39 8,7674 0,0566 Q9JL62 Glycolipid transfer protein Gltp 2 0,0854 3 5,9145 0,6439 NaN 1 6,0673 1,0000 P62334 26S protease regulatory subunit Psmc6 6 -0,0902 6 6,8516 0,6444 0,6484 5 6,5554 0,6233 10B Q0VG47 Heterogeneous nuclear Hnrnpa3 10 0,0852 9 6,5664 0,6449 0,1093 12 7,3782 0,8110 ribonucleoprotein A3 Q99KK7 Dipeptidyl peptidase 3 Dpp3 10 0,0690 10 6,8607 0,6451 0,9485 9 7,0393 0,5209 Q543H0 Spermidine synthase Srm 8 0,0845 11 6,5465 0,6475 0,8397 12 7,0963 0,5958 P08752 Guanine nucleotide-binding Gnai2 9 0,0683 16 7,3885 0,6483 0,0222 10 7,6446 0,7360 protein G(i) subunit alpha-2 B2RSV4 Splicing factor 3B subunit 3 Sf3b3 29 -0,0887 33 7,5729 0,6498 -0,1980 19 7,3701 0,5584 P08775 DNA-directed RNA polymerase II Polr2a 19 -0,0887 12 6,8181 0,6499 0,4307 12 6,6900 0,8242 subunit RPB1 Q8K1X4 NCK associated protein 1 like Nckap1l 13 -0,0886 11 6,7653 0,6502 -0,0935 8 7,0912 0,6401 Q8CIN4 Serine/threonine-protein kinase Pak2 8 0,0679 8 6,7452 0,6503 2,3716 5 7,1929 0,0358 PAK 2 Q569Z5 Probable ATP-dependent RNA Ddx46 23 -0,0886 24 7,2356 0,6503 1,5145 16 7,1572 0,2219 helicase DDX46 Q9CPV4 Glyoxalase domain-containing Glod4 5 -0,1044 5 6,2282 0,6508 1,0835 9 6,8021 0,3033 protein 4 P54227 Stathmin Stmn1 15 -0,0884 19 7,5460 0,6508 2,2482 9 7,3675 0,0485 Q3U0V1 Far upstream element-binding Khsrp 15 0,0667 19 7,4878 0,6562 1,4093 13 7,5134 0,2654 protein 2 E9Q5T9 Signal transducer and activator of Stat2 7 -0,0869 8 6,6694 0,6565 0,1936 3 6,2436 0,9392 transcription 2 Q9DBP5 UMP-CMP kinase Cmpk1 10 0,0664 10 6,6882 0,6575 1,9774 11 6,8533 0,0900 P13864 DNA (cytosine-5)- Dnmt1 6 -0,1021 6 6,2285 0,6581 -0,5146 3 5,8779 0,3096 methyltransferase 1 Q3U3H5 N-acetylgalactosamine kinase Galk2 4 -0,1012 4 6,0340 0,6610 0,3165 3 6,0897 0,9355 G5E8N7 Bifunctional polynucleotide Pnkp 2 0,0808 2 5,6679 0,6617 NaN 1 5,7602 1,0000 phosphatase/kinase O55029 Coatomer subunit beta Copb2 10 -0,0854 12 6,6884 0,6622 0,6047 9 6,9187 0,7719 A2A4A7 1-phosphatidylinositol 4,5- Plcg1 6 0,0805 6 6,3385 0,6628 1,2844 2 6,0407 0,2014 bisphosphate phosphodiesterase gamma-1 P46638 Ras-related protein Rab-11B Rab11b 9 -0,0852 11 6,9982 0,6629 0,5949 15 7,3454 0,7796 Q9Z2I0 LETM1 and EF-hand domain- Letm1 2 0,0800 4 6,1125 0,6649 NaN 1 5,4150 1,0000 containing protein 1, mitochondrial Q8VIJ6 Splicing factor, proline- and Sfpq 20 0,0647 25 7,5272 0,6654 0,4466 42 7,9568 0,8982 glutamine-rich H7BXB7 Heterogeneous nuclear Hnrnpk 16 0,0646 13 7,6160 0,6660 1,4149 17 8,1152 0,2629 ribonucleoprotein K G5E902 Phosphate carrier protein, Slc25a3 14 -0,0841 16 7,3728 0,6670 -0,6258 23 8,1141 0,2860 mitochondrial Q61035 Histidine--tRNA ligase, Hars 10 -0,0840 11 6,8161 0,6675 1,3380 4 6,8295 0,2980 cytoplasmic O35226-2 26S proteasome non-ATPase Psmd4 4 -0,0989 4 6,1741 0,6682 NaN 0 NaN 1,0000 regulatory subunit 4 Q9CX56 26S proteasome non-ATPase Psmd8 5 -0,0837 6 6,7620 0,6686 0,1542 8 7,0527 0,8505 regulatory subunit 8 Q9Z2X1 Heterogeneous nuclear Hnrnpf 15 -0,0836 23 7,9206 0,6688 -0,5786 21 7,8794 0,3107 ribonucleoprotein F B2RY56 RNA-binding protein 25 Rbm25 3 -0,0986 3 6,3955 0,6691 NaN 1 5,6665 1,0000 Q8CBB7 AP-1 complex subunit gamma-1 Ap1g1 5 0,0789 4 6,0622 0,6692 1,1562 2 6,1446 0,2631 A2ANM4 S-methyl-5-thioadenosine Mtap 8 0,0639 11 6,6718 0,6694 1,3689 9 6,8791 0,2836 phosphorylase Q7TSI3 Serine/threonine-protein Ppp6r1 5 -0,0985 3 5,8891 0,6695 1,4882 3 6,1203 0,1261 phosphatase 6 regulatory subunit 1 E9Q3G8 Protein Nup153 Nup153 4 -0,0985 2 5,7620 0,6696 0,5534 2 6,0450 0,7086 B2RRH9 GMP synthase [glutamine- Gmps 12 -0,0833 13 6,8525 0,6700 0,2298 8 6,6377 0,9775 hydrolyzing] Q7TSZ0 Stress-70 protein, mitochondrial Hspa9 24 -0,0829 26 7,6782 0,6714 -0,2550 50 7,9919 0,5161 E9PYH2 Cytosolic acyl coenzyme A Acot7 4 0,0779 3 6,0817 0,6729 0,4122 2 6,5196 0,8421 thioester hydrolase P80316 T-complex protein 1 subunit Cct5 7 0,0631 7 6,9065 0,6733 0,6297 6 7,4480 0,7524 epsilon F6ZDG3 Deubiquitinating protein VCIP135 Vcpip1 3 -0,0969 3 5,7921 0,6747 NaN 0 NaN 1,0000

A2AR77 26S proteasome non-ATPase Psmd14 4 -0,0968 2 6,0729 0,6751 -0,4243 4 6,5853 0,3701 regulatory subunit 14 G3X8Y3 N-alpha-acetyltransferase 15, Naa15 8 -0,0964 7 6,4305 0,6762 0,4488 6 6,6447 0,8069 NatA auxiliary subunit E9PVA8 Protein Gcn1l1 Gcn1l1 25 -0,0816 9 6,6885 0,6766 -0,0182 20 6,8821 0,7020 Q3U7R1 Extended synaptotagmin-1 Esyt1 31 -0,0815 40 7,7599 0,6769 0,8797 18 7,3771 0,5677 Q542H2 Proteasome subunit alpha type Psma7 13 -0,0814 13 7,3938 0,6771 2,0434 16 7,5094 0,0779 P58252 Elongation factor 2 Eef2 53 0,0621 74 8,2030 0,6780 0,2727 51 8,5702 0,9561 E9QNQ2 Serine/threonine-protein Ankrd44 7 -0,0811 10 6,7610 0,6782 -0,0733 2 6,4741 0,6668 phosphatase 6 regulatory ankyrin repeat subunit B P60843 Eukaryotic initiation factor 4A-I Eif4a1 16 -0,0810 24 7,9234 0,6786 -0,4095 22 8,1276 0,4103 Q3TIV6 Lysyl-tRNA synthetase Kars 14 0,0620 13 6,8093 0,6787 0,5830 16 7,0643 0,7889 A2A5L8 Serine/threonine-protein kinase 4 Stk4 7 0,0763 4 6,4222 0,6793 NaN 1 6,0267 1,0000

Q4FJK0 2,4-dienoyl-CoA reductase, Decr1 2 0,0759 2 5,6718 0,6809 -0,2510 2 6,0639 0,5053 mitochondrial Q5BKQ9 26S proteasome non-ATPase Psmd11 11 -0,0803 9 7,1349 0,6813 -0,1326 12 7,4650 0,6090 regulatory subunit 11 E9PWH9 Ribosomal protein L15 Gm4294 5 -0,0944 5 6,3448 0,6825 -0,5799 6 6,6030 0,2702 P62717 60S ribosomal protein L18a Rpl18a 9 -0,0942 5 6,2018 0,6834 0,1326 19 7,5517 0,8315 Q9CPP0 Nucleoplasmin-3 Npm3 2 -0,0941 4 6,2419 0,6836 -0,0633 7 6,6056 0,6765 Q3TKT4-2 Transcription activator BRG1 Smarca4 11 -0,0795 8 6,7507 0,6843 -0,4480 6 6,2026 0,3536 E9QK78 Signal transducer and activator of Stat1 49 0,0602 72 8,2860 0,6874 -0,0306 89 8,7049 0,6916 transcription 1 A2RTT4 Ubiquitin-conjugating enzyme E2 Ube2n 3 0,0742 2 6,0720 0,6874 1,5120 5 6,4558 0,1190 N Q9DBZ5 Eukaryotic translation initiation Eif3k 3 -0,0928 6 6,3611 0,6876 0,8313 4 6,1231 0,4731 factor 3 subunit K Q80TT4 Mitochondrial import receptor Tomm70a 2 0,0740 2 5,9294 0,6885 -0,3993 3 6,1315 0,3881 subunit TOM70 P41105 60S ribosomal protein L28 Rpl28 8 0,0737 5 6,4479 0,6896 -0,4800 10 7,3397 0,3667 Q9CSH3 Exosome complex exonuclease Dis3 9 -0,0919 6 6,3047 0,6907 -1,4710 5 6,5804 0,0223 RRP44 P68372 Tubulin beta-4B chain Tubb4b 23 -0,0776 11 7,6779 0,6917 -0,2585 2 7,4771 0,5136 A2BH28 SUMO-activating enzyme subunit Uba2 15 -0,0776 26 7,2678 0,6917 1,0493 14 6,9883 0,4562 2 P63073 Eukaryotic translation initiation Eif4e 4 0,0730 5 6,5100 0,6923 2,2728 2 5,7396 0,0124 factor 4E P48722 Heat shock 70 kDa protein 4L Hspa4l 4 0,0730 2 5,5917 0,6923 NaN 0 NaN 1,0000 Q8VBV7 COP9 signalosome complex Cops8 3 -0,0912 2 5,5835 0,6930 0,7190 2 5,5860 0,5629 subunit 8 E9QAS5 Chromodomain-helicase-DNA- Chd4 25 -0,0771 19 7,0739 0,6935 -0,0225 13 6,9184 0,6984 binding protein 4 P68510 14-3-3 protein eta Ywhah 19 0,0588 9 6,9968 0,6941 1,3703 19 7,7528 0,2829 Q61081 Hsp90 co-chaperone Cdc37 Cdc37 3 -0,0902 3 6,0619 0,6961 NaN 1 5,7930 1,0000 Q8BKC5 Importin-5 Ipo5 23 0,0581 22 7,2152 0,6975 0,4883 13 7,1076 0,8645 B1AUX2 Host cell factor 1 Hcfc1 14 0,0581 11 6,8741 0,6975 0,1182 10 6,9142 0,8189 E9Q975 Serine/arginine-rich splicing Srsf2 6 0,0581 7 7,2644 0,6975 1,1550 7 7,6238 0,3935 factor 2 Q8C7R4 Ubiquitin-like modifier-activating Uba6 6 0,0716 6 6,1616 0,6977 -0,3174 3 6,0482 0,4506 enzyme 6 Q9D0K2 Succinyl-CoA:3-ketoacid- Oxct1 4 0,0715 2 6,2843 0,6982 0,7971 2 6,4201 0,4996 coenzyme A transferase 1, mitochondrial Q6P4T2 U5 small nuclear Snrnp200 57 -0,0752 55 7,7677 0,7010 -0,5622 55 7,6772 0,3196 ribonucleoprotein 200 kDa helicase P17426 AP-2 complex subunit alpha-1 Ap2a1 11 0,0707 10 6,4579 0,7015 0,5252 5 6,2748 0,7347 P52633 Signal transducer and Stat6 4 0,0705 3 5,9674 0,7020 NaN 1 5,3291 1,0000 transcription activator 6 P70168 Importin subunit beta-1 Kpnb1 21 0,0571 24 7,3176 0,7022 0,3725 30 7,8506 0,9584 P97823 Acyl-protein thioesterase 1 Lypla1 2 0,0703 2 6,1565 0,7031 1,2287 3 6,5916 0,2268 P12815 Programmed cell death protein 6 Pdcd6 3 0,0701 7 6,4514 0,7037 0,6665 7 6,6721 0,6075

P59999 Actin-related protein 2/3 complex Arpc4 14 0,0567 23 7,8597 0,7042 1,4165 21 8,0783 0,2622 subunit 4 Q9CXW3 Calcyclin-binding protein Cacybp 8 -0,0741 10 6,6484 0,7051 1,7436 6 6,4899 0,0650 Q9JHR7 Insulin-degrading enzyme Ide 17 -0,0740 12 6,8411 0,7056 0,4050 10 6,8292 0,9319 Q9CR00 26S proteasome non-ATPase Psmd9 2 -0,0868 2 5,7526 0,7072 1,2444 2 5,8204 0,2194 regulatory subunit 9 B2RTB0 28 kDa heat- and acid-stable Pdap1 7 0,0692 7 6,2423 0,7075 1,8806 4 6,0455 0,0439 phosphoprotein Q6ZQ08-4 CCR4-NOT transcription complex Cnot1 22 -0,0862 7 6,4121 0,7091 0,3524 16 6,6689 0,9003 subunit 1 P20108 Thioredoxin-dependent peroxide Prdx3 8 -0,0730 6 6,8981 0,7093 0,7637 9 7,3410 0,6508 reductase, mitochondrial Q5SUR0 Phosphoribosylformylglycinamidi Pfas 29 0,0553 34 7,6962 0,7110 0,8453 17 7,2578 0,5918 ne synthase P70441 Na(+)/H(+) exchange regulatory Slc9a3r1 4 0,0676 3 6,4911 0,7135 1,5917 3 6,5080 0,0974 cofactor NHE-RF1 Q9QZ73 DCN1-like protein 1 Dcun1d1 2 0,0676 4 5,7866 0,7135 NaN 1 5,2101 1,0000 O88738 Baculoviral IAP repeat-containing Birc6 5 -0,0846 3 5,8549 0,7144 NaN 1 5,0984 1,0000 protein 6 P80317 T-complex protein 1 subunit zeta Cct6a 16 0,0545 21 7,5778 0,7151 0,2314 14 7,7053 0,9191

Q9EST5-2 Acidic leucine-rich nuclear Anp32b 11 -0,0712 13 7,3410 0,7162 1,4859 23 7,8446 0,2332 phosphoprotein 32 family member B P17742 Peptidyl-prolyl cis-trans Ppia 16 0,0537 40 8,6480 0,7193 2,4711 37 8,8820 0,0277 isomerase A Q3ULF7 Actin-related protein 3 Actr3 17 0,0533 27 7,9545 0,7213 0,7114 12 7,6005 0,6898 A8IP69 14-3-3 protein gamma Ywhag 18 -0,0698 5 6,8740 0,7218 1,4213 10 7,3062 0,2602 F8VPK0 Protein Ttc37 Ttc37 2 -0,0822 2 5,6271 0,7222 NaN 0 NaN 1,0000 Q9JIF7 Coatomer subunit beta Copb1 12 0,0652 6 6,3637 0,7235 0,4700 10 6,9086 0,8792 D3Z6N6 40S ribosomal protein S6 Rps6-ps1 4 -0,0818 4 6,2209 0,7236 -0,0539 9 6,8877 0,6724 Q543K9 Purine nucleoside phosphorylase Pnp 11 -0,0692 15 6,8924 0,7239 1,6837 4 6,7367 0,0765

P56399 Ubiquitin carboxyl-terminal Usp5 10 -0,0816 8 6,4843 0,7242 1,0591 4 6,4836 0,3178 hydrolase 5 A2BH07 60S ribosomal protein L11 Rpl11 9 0,0526 6 7,0633 0,7247 0,2308 17 7,8993 0,9186 Q9DC51 Guanine nucleotide-binding Gnai3 9 0,0647 5 6,2136 0,7251 0,0746 4 6,5626 0,8149 protein G(k) subunit alpha Q9CZ30 Obg-like ATPase 1 Ola1 2 0,0645 2 5,9190 0,7262 0,3216 3 6,9442 1,0000 Q01768 Nucleoside diphosphate kinase B Nme2 12 -0,0676 19 8,1404 0,7300 3,0826 14 7,7774 0,0047

Q60597-3 2-oxoglutarate dehydrogenase, Ogdh 16 0,0514 16 6,8887 0,7303 -0,7409 12 6,9485 0,2315 mitochondrial Q6PDI5 Proteasome-associated protein Ecm29 10 -0,0793 6 6,3697 0,7316 0,2881 6 6,3632 0,9635 ECM29 homolog Q99JI4 26S proteasome non-ATPase Psmd6 12 -0,0672 15 7,4907 0,7319 -0,0341 6 6,8073 0,6888 regulatory subunit 6 Q91VR5 ATP-dependent RNA helicase Ddx1 10 0,0628 8 6,3688 0,7329 0,6466 10 6,8974 0,7393 DDX1 Q9DCW4 Electron transfer flavoprotein Etfb 12 -0,0658 11 6,7779 0,7370 0,5145 12 7,1342 0,8434 subunit beta Q99KI3 Transmembrane protein 111 Tmem111 3 -0,0774 2 5,4250 0,7380 0,0530 5 5,9706 0,7926 P60335 Poly(rC)-binding protein 1 Pcbp1 11 0,0498 11 7,1187 0,7386 0,5252 13 7,5927 0,8349 P11499 Heat shock protein HSP 90-beta Hsp90ab1 60 -0,0653 82 8,5850 0,7391 0,3738 109 8,9214 0,9573 P34022 Ran-specific GTPase-activating Ranbp1 8 0,0496 13 7,3104 0,7393 2,0758 16 7,5492 0,0725 protein Q99L13 3-hydroxyisobutyrate Hibadh 2 -0,0769 3 5,6005 0,7398 NaN 1 5,3875 1,0000 dehydrogenase, mitochondrial E9Q8T5 Coiled-coil domain-containing Ccdc88b 5 0,0610 4 5,6804 0,7402 0,7791 2 5,5304 0,5138 protein 88B P62264 40S ribosomal protein S14 Rps14 4 -0,0767 4 6,5089 0,7402 -0,6152 5 7,0506 0,2914 Q99JZ4 GTP-binding protein SAR1a Sar1a 5 -0,0762 4 6,5664 0,7418 0,0812 8 7,0066 0,7866 A2AQH9 Cleavage stimulation factor Cstf3 3 0,0606 4 5,9806 0,7418 NaN 1 5,5107 1,0000 subunit 3 B1ARK2 26S protease regulatory subunit 8 Psmc5 7 -0,0646 5 6,6491 0,7420 0,2013 4 6,5769 0,9473

Q9CR57 60S ribosomal protein L14 Rpl14 6 0,0603 4 6,5553 0,7430 -0,6257 12 7,4315 0,2860 O08788 Dynactin subunit 1 Dctn1 11 0,0600 5 6,4373 0,7441 0,7141 4 6,0836 0,5670 F6ZFU0 Elongation factor 1-delta Eef1d 9 -0,0639 9 6,6887 0,7444 1,1106 14 7,5082 0,4192 Q9CYN2 Signal peptidase complex subunit Spcs2 6 -0,0639 9 6,7939 0,7445 -0,0417 15 6,9351 0,6824 2 Q9CZU6 Citrate synthase, mitochondrial Cs 11 -0,0638 14 7,4817 0,7450 0,1200 16 7,8286 0,8204 Q07417 Short-chain specific acyl-CoA Acads 7 -0,0753 4 6,0267 0,7451 -0,3429 7 6,9647 0,4543 dehydrogenase, mitochondrial Q64152 Transcription factor BTF3 Btf3 4 -0,0752 5 6,5843 0,7453 1,0610 5 6,9658 0,4490 Q99J77 N-acetylneuraminic acid synthase Nans 5 0,0592 3 6,3481 0,7474 0,7374 3 6,6485 0,5476

P20060 Beta-hexosaminidase subunit Hexb 6 0,0589 3 6,4945 0,7486 0,7434 6 6,9565 0,6658 beta Q9CZU3 Superkiller viralicidic activity 2- Skiv2l2 14 -0,0627 16 7,0166 0,7491 0,0115 8 6,6979 0,7505 like 2 E9Q6R7 Utrn 10 0,0588 10 6,3539 0,7491 0,6215 3 5,7529 0,6469 Q91VI7 Ribonuclease inhibitor Rnh1 6 0,0585 4 6,4351 0,7502 -0,1866 6 6,9797 0,5671 Q9CQ60 6-phosphogluconolactonase Pgls 8 -0,0734 10 6,5928 0,7514 1,5077 10 6,8059 0,1202 Q9D0R2 Threonine--tRNA ligase, Tars 9 -0,0618 11 6,7500 0,7528 0,0524 11 7,0704 0,7618 cytoplasmic P27612 Phospholipase A-2-activating Plaa 5 0,0578 3 5,9855 0,7531 -0,3399 4 6,1584 0,4329 protein Q3TJC2 Platelet-activating factor Pafah1b3 3 0,0576 3 6,2019 0,7542 1,3675 4 6,3925 0,1675 acetylhydrolase IB subunit gamma Q8VDD5 Myosin-9 Myh9 229 0,0466 390 9,2389 0,7546 -0,0192 272 8,9425 0,7012 Q5XJF6 Ribosomal protein Rpl10a 14 0,0466 13 7,2279 0,7546 0,5303 25 7,9298 0,8308 Q9ESX5 H/ACA ribonucleoprotein Dkc1 5 -0,0723 3 6,1871 0,7549 -3,2305 9 7,0588 0,0001 complex subunit 4 Q540D7 Alcohol dehydrogenase [NADP(+)] Akr1a1 7 -0,0717 4 6,4827 0,7568 0,7631 10 7,2001 0,6512

P40142 Transketolase Tkt 31 0,0460 33 8,0442 0,7574 1,3795 31 7,7369 0,2787 P0CG50 Polyubiquitin-C Ubc 11 -0,0601 64 7,9570 0,7595 -0,1978 64 8,1769 0,5586 Q8BVQ9 26S protease regulatory subunit 7 Psmc2 11 -0,0599 13 6,8840 0,7604 0,2772 5 6,8230 0,9601

D3Z7P3 Glutaminase kidney isoform, Gls 2 -0,0706 3 6,2923 0,7605 NaN 0 NaN 1,0000 mitochondrial Q99JY0 Trifunctional enzyme subunit Hadhb 11 0,0453 4 6,9722 0,7609 -0,2616 13 7,1991 0,5113 beta, mitochondrial Q6ZQ45 Nuclear pore complex protein Nup155 16 0,0452 13 6,6784 0,7616 -0,4502 16 6,9390 0,3847 Nup155 P45952 Medium-chain specific acyl-CoA Acadm 4 -0,0700 4 6,1728 0,7626 -1,0701 2 6,4141 0,0796 dehydrogenase, mitochondrial B1AYC9 Amyloid beta A4 precursor Apbb1ip 3 -0,0700 4 6,0799 0,7626 NaN 1 5,2434 1,0000 protein-binding family B member 1-interacting protein O35350 Calpain-1 catalytic subunit Capn1 22 -0,0593 24 7,3824 0,7627 0,6033 23 7,4284 0,7730 P00375 Dihydrofolate reductase Dhfr 8 0,0553 6 6,3747 0,7632 -0,1088 8 6,7422 0,6329 E9QKR0 Guanine nucleotide-binding Gnb2 8 0,0447 3 6,6579 0,7637 0,5790 14 7,9073 0,7921 protein G(I)/G(S)/G(T) subunit beta-2 A2AH73 6-phosphogluconate Pgd 8 0,0445 11 7,3881 0,7651 0,3868 9 6,9834 0,9468 dehydrogenase, decarboxylating Q99MR6 Serrate RNA effector molecule Srrt 21 0,0440 14 7,2539 0,7672 0,7596 14 7,2623 0,6538 homolog B1B1B4 Electron transfer flavoprotein Etfa 7 0,0435 8 7,1801 0,7700 -0,3405 9 7,0916 0,4559 subunit alpha, mitochondrial Q9EPU0 Regulator of nonsense transcripts Upf1 13 -0,0574 12 6,7595 0,7703 -0,5070 8 6,6989 0,3144 1 Q5SQB7 Nucleophosmin Npm1 16 0,0433 23 7,4662 0,7708 -0,4411 32 7,8926 0,3904 Q6NSR8 Probable aminopeptidase NPEPL1 Npepl1 2 0,0527 2 5,9271 0,7740 NaN 1 5,7538 1,0000

P14152 Malate dehydrogenase, Mdh1 15 0,0426 16 7,6233 0,7743 1,3036 23 8,0171 0,3147 cytoplasmic P62192 26S protease regulatory subunit 4 Psmc1 9 -0,0563 8 6,7351 0,7746 1,4855 2 6,7513 0,1269

Q61233 Plastin-2 Lcp1 40 -0,0561 55 8,0243 0,7751 1,1932 55 8,2192 0,3722 Q61990 Poly(rC)-binding protein 2 Pcbp2 6 0,0521 7 6,5548 0,7763 -0,5519 3 6,7676 0,2866 Q8BK64 Activator of 90 kDa heat shock Ahsa1 5 0,0422 7 6,7314 0,7764 1,2827 6 6,7816 0,2021 protein ATPase homolog 1 E9PX78 Eukaryotic translation initiation Eif3b 14 -0,0558 20 7,0139 0,7765 0,3155 11 7,3033 0,9945 factor 3 subunit B Q1HFZ0 tRNA (cytosine(34)-C(5))- Nsun2 8 -0,0658 6 6,4201 0,7766 0,6097 9 6,7431 0,6575 methyltransferase Q3UKF5 Xaa-Pro aminopeptidase 1 Xpnpep1 3 -0,0658 5 6,1857 0,7767 0,4312 2 6,0234 0,8237 P54822 Adenylosuccinate lyase Adsl 3 -0,0656 6 6,5828 0,7774 NaN 1 6,4271 1,0000 P67984 60S ribosomal protein L22 Rpl22 3 0,0419 4 6,7367 0,7778 -0,3474 2 6,0701 0,4271 G3UY42 Polyadenylate-binding protein 2 Pabpn1 2 0,0517 2 6,1622 0,7780 NaN 0 NaN 1,0000 Q61210-5 Rho guanine nucleotide exchange Arhgef1 25 0,0418 29 7,4920 0,7785 0,9126 12 7,1706 0,5451 factor 1 B2RVD5 Histone H2B Hist1h2bk 21 -0,0551 6 7,3042 0,7794 -0,4814 6 7,7037 0,3658 P35123 Ubiquitin carboxyl-terminal Usp4 3 0,0513 3 5,7788 0,7797 NaN 1 5,9739 1,0000 hydrolase 4 A2A5V4 SH3 domain-binding protein 1 Sh3bp1 6 0,0510 7 6,5945 0,7809 1,2182 6 6,4487 0,2318 Q0PD66 Ras-related protein Rab-1B Rab1b 9 -0,0644 7 6,3831 0,7812 -0,0108 6 6,6115 0,7282 D3Z6J9 60S ribosomal protein L27a Gm5908 3 0,0507 4 6,5195 0,7820 0,1587 5 6,9282 0,8545 E9PWZ5 F-actin-capping protein subunit Capza1 6 -0,0631 6 6,5198 0,7857 0,7191 4 6,9674 0,6840 alpha-1 F8WIA1 CAP-Gly domain-containing linker Clip1 4 0,0496 2 6,0051 0,7866 0,7909 2 5,4336 0,5044 protein 1 Q9CQX2 Cytochrome b5 type B Cyb5b 3 0,0496 5 6,4457 0,7866 -0,0836 5 6,6588 0,6569 P97821 Dipeptidyl peptidase 1 Ctsc 3 -0,0531 6 6,8750 0,7870 0,4553 6 6,7789 0,8006 P61358 60S ribosomal protein L27 Rpl27 10 0,0400 5 6,8083 0,7878 0,0849 16 7,4698 0,7898 Q8CH18 Cell division cycle and apoptosis Ccar1 7 -0,0528 7 6,6694 0,7885 NaN 1 5,7113 1,0000 regulator protein 1 Q3UBU9 Peptidyl-prolyl cis-trans Fkbp3 8 -0,0622 6 6,4168 0,7885 2,0867 10 6,8984 0,0707 isomerase Q3TXS7 26S proteasome non-ATPase Psmd1 17 -0,0525 18 7,1168 0,7896 0,2201 11 7,0528 0,9090 regulatory subunit 1 Q9QY81 Nuclear pore membrane Nup210 36 0,0396 30 7,3568 0,7899 -1,5401 48 7,6526 0,0360 glycoprotein 210 Q9ERD7 Tubulin beta-3 chain Tubb3 14 0,0488 2 6,5984 0,7901 NaN 0 NaN 1,0000 Q7TQI3 Ubiquitin thioesterase OTUB1 Otub1 3 -0,0616 2 6,0616 0,7909 1,5799 6 6,8781 0,1976 P35979 60S ribosomal protein L12 Rpl12 10 0,0393 10 7,5153 0,7913 0,4555 18 7,8490 0,8909 F8WGL3 Cofilin-1 Cfl1 23 0,0391 49 8,5306 0,7920 2,2447 23 8,4667 0,0489 P10711 Transcription elongation factor A Tcea1 4 -0,0612 5 6,1816 0,7921 1,2476 3 6,4068 0,2179 protein 1 Q8K1M6 Dynamin-1-like protein Dnm1l 4 -0,0606 3 5,7573 0,7940 NaN 1 5,3506 1,0000 Q9JIF0 Protein arginine N- Prmt1 9 0,0477 4 6,4303 0,7947 0,2630 10 7,2204 0,9474 methyltransferase 1 Q3U2G2 Heat shock 70 kDa protein 4 Hspa4 38 -0,0511 38 7,7132 0,7953 1,1920 15 7,4392 0,3728 Q8C605 6-phosphofructokinase Pfkp 28 0,0384 30 7,5184 0,7956 0,1023 41 8,0404 0,8050 P62908 40S ribosomal protein S3 Rps3 18 0,0384 22 7,4669 0,7956 -0,2561 44 7,9446 0,5153 A2AH85 116 kDa U5 small nuclear Eftud2 27 -0,0507 33 7,3280 0,7969 -0,6660 18 7,2531 0,2661 ribonucleoprotein component B8JJL8 Programmed cell death 6- Pdcd6ip 22 0,0379 22 7,2714 0,7985 0,6467 22 7,5424 0,7392 interacting protein Q545E6 Translin Tsn 8 0,0466 3 5,9374 0,7993 2,1696 7 6,7379 0,0177 P97822 Acidic leucine-rich nuclear Anp32e 3 -0,0499 6 6,7325 0,7998 0,7481 8 7,2401 0,6623 phosphoprotein 32 family member E P63085 Mitogen-activated protein kinase Mapk1 6 0,0464 6 6,4697 0,7999 0,4623 2 6,6179 0,7940 1 Q54AA2 Apoptosis-associated speck-like Pycard 5 -0,0499 3 6,6591 0,8001 1,2071 3 6,3018 0,2372 protein containing a CARD B2RT97 26S proteasome non-ATPase Psmd13 5 -0,0586 6 6,4858 0,8007 -0,2795 6 7,0641 0,4985 regulatory subunit 13 P42209 Septin-1 Sept1 18 -0,0486 12 7,3255 0,8050 0,0233 20 7,7070 0,7369 Q9DAY9 Nucleophosmin Npm1 13 -0,0569 2 5,7801 0,8066 -0,1762 4 6,2066 0,5707 P61205 ADP-ribosylation factor 3 Arf3 13 -0,0476 16 7,4713 0,8092 0,9015 17 7,5803 0,5527 Q9DBK7 Protein Uba7 Uba7 4 -0,0552 3 5,7205 0,8124 NaN 1 5,8936 1,0000 P60766 Cell division control protein 42 Cdc42 7 0,0433 3 5,7313 0,8126 1,4989 5 6,9046 0,2280 homolog P63005 Platelet-activating factor Pafah1b1 5 -0,0551 8 6,4687 0,8128 0,7206 3 6,5267 0,5615 acetylhydrolase IB subunit alpha P47963 60S ribosomal protein L13 Rpl13 9 -0,0467 11 6,8385 0,8128 0,2101 19 7,4886 0,9001 Q64511 DNA topoisomerase 2-beta Top2b 35 0,0351 27 7,3095 0,8128 -0,7529 32 7,4404 0,2262 Q8K4Z5 Splicing factor 3A subunit 1 Sf3a1 22 -0,0467 25 7,4413 0,8129 0,9780 9 6,9708 0,5015 Q9JJ28 Protein flightless-1 homolog Flii 12 -0,0465 11 6,6209 0,8133 0,9714 6 6,3895 0,3731 Q99KP6 Pre-mRNA-processing factor 19 Prpf19 7 0,0346 7 6,6038 0,8150 -0,3025 3 6,9024 0,4821 Q91V55 40S ribosomal protein S5 Rps5 10 0,0345 9 7,4154 0,8157 0,0778 11 7,7740 0,7837 Q4VA29 UPF0568 protein C14orf166 2700060E02Rik 6 0,0419 2 5,3110 0,8184 0,4961 6 6,4166 0,7619 homolog P70670 Nascent polypeptide-associated Naca 6 0,0339 10 6,8403 0,8186 1,4868 9 7,3969 0,2329 complex subunit alpha, muscle- specific form P26041 Moesin Msn 44 0,0338 64 8,4532 0,8193 1,2783 68 8,5009 0,3273 Q6P069 Sorcin Sri 9 0,0337 7 7,2536 0,8200 1,2348 16 7,6535 0,3498 Q9CQF3 Cleavage and polyadenylation Nudt21 8 0,0332 9 6,6116 0,8222 0,7873 11 6,7622 0,5073 specificity factor subunit 5 A2RS22 Coronin-1B Coro1b 5 -0,0440 5 7,0321 0,8236 1,6633 3 7,1054 0,1695 Q8BGQ7 Alanine--tRNA ligase, cytoplasmic Aars 16 -0,0440 19 7,1116 0,8237 0,1452 12 7,0307 0,8426

P61202-2 COP9 signalosome complex Cops2 4 -0,0513 4 6,2730 0,8255 0,5881 3 6,2697 0,6769 subunit 2 Q9JHU4 Cytoplasmic dynein 1 heavy chain Dync1h1 129 -0,0433 167 8,1001 0,8262 0,2286 53 7,4178 0,9166 1 Q545G0 Proteasome subunit beta type Psmb3 7 -0,0431 13 7,2086 0,8272 1,1420 11 7,2733 0,4009 Q5SX53 Mitochondrial 2- Slc25a11 9 -0,0504 6 6,1855 0,8285 -0,7803 14 6,9354 0,2146 oxoglutarate/malate carrier protein Q99LF4 tRNA-splicing ligase RtcB D10Wsu52e 5 -0,0500 4 6,3190 0,8299 0,2179 4 7,1733 0,9070 homolog P62702 40S ribosomal protein S4, X Rps4x 10 0,0317 11 6,7106 0,8302 -0,9679 16 7,7368 0,1464 isoform Q3TCU5 Tapasin Tapbp 9 -0,0419 11 7,6318 0,8321 -0,5551 15 7,7396 0,3235 E9QNJ0 60S ribosomal protein L24 Rpl24 5 -0,0491 3 6,4688 0,8330 0,5099 9 7,1312 0,8471 P61087 Ubiquitin-conjugating enzyme E2 Ube2k 5 -0,0487 5 6,2986 0,8344 1,2402 7 6,3869 0,2213 K Q922D8 C-1-tetrahydrofolate synthase, Mthfd1 32 -0,0413 29 7,5000 0,8345 -0,2747 24 7,6435 0,5019 cytoplasmic P99026 Proteasome subunit beta type-4 Psmb4 9 0,0308 13 7,3354 0,8345 1,9795 15 7,4952 0,0896 O55135 Eukaryotic translation initiation Eif6 4 0,0379 6 6,2976 0,8354 0,4022 6 6,5471 0,8518 factor 6 P59325 Eukaryotic translation initiation Eif5 3 0,0379 2 5,9096 0,8354 1,3402 2 6,1050 0,1781 factor 5 A2AFW7 Mitochondrial carrier homolog 2 Mtch2 5 -0,0476 4 6,0656 0,8381 -0,5200 5 6,5022 0,3062 Q6PK77 Adenine Aprt 6 -0,0401 10 6,8452 0,8395 2,1822 9 6,9982 0,0568 phosphoribosyltransferase A2AFQ2 3-hydroxyacyl-CoA Hsd17b10 10 -0,0397 12 6,7586 0,8410 -0,4880 14 7,3741 0,3619 dehydrogenase type-2 Q8QZY1 Eukaryotic translation initiation Eif3l 9 0,0365 3 6,0716 0,8413 0,8050 6 7,0154 0,6206 factor 3 subunit L A2A5S1 Exportin-2 Cse1l 21 -0,0394 30 8,0748 0,8420 -0,2474 33 8,5861 0,5216 B7ZCF1 26S protease regulatory subunit Psmc3 5 0,0362 4 6,4738 0,8425 -0,1651 3 6,5387 0,5807 6A Q8CG47 Structural maintenance of Smc4 24 -0,0393 13 6,9109 0,8425 -0,4517 16 6,9955 0,3838 chromosomes protein 4 Q9CRA8 Exosome complex component Exosc5 2 -0,0462 2 5,6494 0,8429 0,5306 4 6,1020 0,7297 RRP46 A2AFQ0 E3 ubiquitin-protein ligase Huwe1 7 0,0359 6 5,9642 0,8436 NaN 1 5,4649 1,0000 HUWE1 Q9WVA3 Mitotic checkpoint protein BUB3 Bub3 4 -0,0459 4 6,3191 0,8440 0,5395 7 6,9180 0,8234 Q9D051 Pyruvate dehydrogenase E1 Pdhb 6 -0,0459 6 6,4995 0,8441 -0,5664 11 7,0758 0,3173 component subunit beta, mitochondrial Q9DCE9 Protein Igtp Igtp 21 -0,0389 28 7,7321 0,8443 -0,1138 22 8,0287 0,6239 Q64525 Histone H2B type 2-B Hist2h2bb 22 -0,0388 70 9,0225 0,8445 -1,2319 96 9,5528 0,0802 Q9CQC6 Basic leucine zipper and W2 Bzw1 6 0,0355 6 6,5675 0,8454 0,2454 4 6,8027 0,9940 domain-containing protein 1 E9Q070 60S acidic ribosomal protein P0 Gm8730 10 0,0287 13 7,4804 0,8455 -0,0085 18 7,8184 0,7101 D3YU49 Eukaryotic initiation factor 4A-III Gm8994 9 -0,0454 3 6,4532 0,8458 -1,0264 6 7,2996 0,1290 Q9DAR7 m7GpppX diphosphatase Dcps 5 0,0348 2 5,9793 0,8484 1,1659 6 7,1732 0,3873 Q5SWR1 AP-2 complex subunit beta Ap2b1 11 0,0346 2 5,4740 0,8490 NaN 1 5,6151 1,0000 Q09200 Beta-1,4 N- B4galnt1 7 -0,0443 7 6,4203 0,8497 -0,6956 13 6,9075 0,2520 acetylgalactosaminyltransferase 1

P40124 Adenylyl cyclase-associated Cap1 18 0,0279 21 7,6495 0,8498 1,7123 10 7,9058 0,1545 protein 1 Q9QUM9 Proteasome subunit alpha type-6 Psma6 11 0,0277 14 7,5094 0,8506 1,5761 18 7,6064 0,1990

G5E866 Splicing factor 3B subunit 1 Sf3b1 29 -0,0370 31 7,6413 0,8519 1,1928 15 7,0518 0,3724 P63101 14-3-3 protein zeta/delta Ywhaz 24 0,0274 32 8,1614 0,8520 1,7230 37 8,4598 0,1513 A2AKT7 Exportin-1 Xpo1 22 0,0273 37 7,5441 0,8528 0,0600 19 7,4405 0,7683 Q99LB6 Methionine adenosyltransferase Mat2b 2 0,0337 3 5,8564 0,8531 0,9453 3 6,3266 0,3907 2 subunit beta Q3UQ44 Ras GTPase-activating-like protein Iqgap2 15 -0,0431 9 6,2518 0,8537 0,5121 3 5,9702 0,7469 IQGAP2 P25976 Nucleolar transcription factor 1 Ubtf 2 -0,0418 2 5,3960 0,8580 NaN 1 5,6459 1,0000 Q9CY58 Plasminogen activator inhibitor 1 Serbp1 5 0,0262 7 6,8857 0,8586 -0,4775 4 6,8360 0,3682 RNA-binding protein A2BGM2 U2 small nuclear Snrpb2 7 0,0320 8 6,4065 0,8602 1,0267 13 6,9531 0,4703 ribonucleoprotein B A1L3B8 26S proteasome non-ATPase Psmd7 6 -0,0410 2 5,7086 0,8609 -0,0467 8 7,0460 0,6783 regulatory subunit 7 E9PV46 40S ribosomal protein S2 Gm8841 10 0,0253 9 6,6664 0,8630 -0,9263 15 7,5610 0,1599 P22682 E3 ubiquitin-protein ligase CBL Cbl 4 -0,0402 2 5,6092 0,8635 NaN 1 5,6015 1,0000 Q3TS44 Proteasome subunit alpha type Psma1 11 0,0252 20 7,4669 0,8638 1,0007 13 7,6084 0,4868 Q6ZWX6 Eukaryotic translation initiation Eif2s1 7 0,0310 5 6,3602 0,8644 0,0649 10 7,0858 0,7725 factor 2 subunit 1 Q8VDN2 Sodium/potassium-transporting Atp1a1 24 -0,0339 30 7,3479 0,8645 0,1029 29 7,6439 0,8054 ATPase subunit alpha-1 E9PZZ3 Protein Tpr Tpr 54 -0,0329 38 7,5336 0,8683 -0,1273 34 7,2195 0,6132 Q3UDE2 Tubulin--tyrosine ligase-like Ttll12 6 0,0298 4 6,0659 0,8691 0,1063 9 6,5011 0,8477 protein 12 Q3TWG5 Cytoplasmic dynein 1 light Dync1li1 4 0,0294 2 5,6320 0,8709 1,7302 2 6,3654 0,0674 intermediate chain 1 P70296 Phosphatidylethanolamine- Pebp1 7 0,0236 6 6,8476 0,8719 1,8953 8 7,3274 0,1071 binding protein 1 E9QNN1 ATP-dependent RNA helicase A Dhx9 24 0,0235 32 7,4663 0,8726 -0,5239 34 7,5897 0,3410 Q9Z1N5 Spliceosome RNA helicase Ddx39b 20 0,0235 32 7,9976 0,8726 -0,2625 25 8,1014 0,5107 Ddx39b Q9EPU4 Cleavage and polyadenylation Cpsf1 9 -0,0375 9 6,5568 0,8731 1,4926 6 6,4112 0,1248 specificity factor subunit 1 Q3TWW8 Protein Srsf6 Srsf6 3 0,0289 2 6,1805 0,8733 -2,1522 2 5,8392 0,0014 A2AFF6 Cohesin subunit SA-2 Stag2 5 0,0286 4 6,0157 0,8745 0,9378 2 5,4781 0,3958 P28063 Proteasome subunit beta type-8 Psmb8 8 0,0229 16 7,3339 0,8756 1,8650 13 7,3802 0,1140 O70251 Elongation factor 1-beta Eef1b 8 -0,0311 9 7,1001 0,8758 0,8314 12 6,9884 0,6017 P24527 Leukotriene A-4 hydrolase Lta4h 9 -0,0364 4 6,4607 0,8767 0,1397 5 6,8179 0,8377 Q6ZQ38 Cullin-associated NEDD8- Cand1 21 0,0222 28 7,5713 0,8793 0,8343 17 7,2726 0,5996 dissociated protein 1 P62137 Serine/threonine-protein Ppp1ca 10 0,0222 8 6,9192 0,8793 0,4740 10 7,3062 0,8759 phosphatase PP1-alpha catalytic subunit P62849 40S ribosomal protein S24 Rps24 5 0,0270 2 6,2310 0,8811 -0,5915 8 7,0662 0,3038 Q8BJY1 26S proteasome non-ATPase Psmd5 7 -0,0347 9 6,5667 0,8825 1,0144 3 6,5799 0,3452 regulatory subunit 5 P50580 Proliferation-associated protein Pa2g4 14 0,0215 17 7,5940 0,8829 0,0774 12 7,5300 0,7833 2G4 F6VW30 14-3-3 protein theta Ywhaq 19 -0,0281 5 6,6027 0,8882 1,6564 14 7,2133 0,1717 P97351 40S ribosomal protein S3a Rps3a 12 -0,0277 11 6,8925 0,8896 -0,5750 20 7,5202 0,3126 O55013 Trafficking protein particle Trappc3 2 0,0246 2 5,8842 0,8912 0,6431 3 6,2018 0,6279 complex subunit 3 G3UW73 Aldose reductase Gm6736 11 -0,0272 11 7,3548 0,8916 1,1713 17 7,9003 0,3843 Q8CC13 AP-1 complex subunit beta-1 Ap1b1 12 -0,0269 13 6,8344 0,8931 0,5337 7 6,7149 0,7268 Q9DBD5 Proline-, glutamic acid- and Pelp1 2 -0,0316 3 6,0450 0,8933 NaN 0 NaN 1,0000 leucine-rich protein 1 Q3UKW2 Calmodulin Calm1 2 -0,0312 3 6,5866 0,8947 2,9309 4 6,7227 0,0009 P60229 Eukaryotic translation initiation Eif3e 8 0,0192 7 6,6306 0,8948 -1,1353 4 6,8563 0,1008 factor 3 subunit E Q3V117 ATP-citrate synthase Acly 12 -0,0262 9 6,6676 0,8958 0,3520 8 6,9343 0,9752 P35486 Pyruvate dehydrogenase E1 Pdha1 4 0,0235 4 6,4875 0,8961 -0,5173 5 6,6027 0,3079 component subunit alpha, somatic form, mitochondrial P26369 Splicing factor U2AF 65 kDa U2af2 5 0,0185 6 6,8191 0,8985 1,1295 5 7,1211 0,4081 subunit Q8C147 Dedicator of cytokinesis protein 8 Dock8 33 -0,0254 25 7,2615 0,8991 0,2514 28 7,1073 0,9370

P70460 Vasodilator-stimulated Vasp 6 0,0181 4 7,1523 0,9007 0,6440 3 6,5484 0,6271 phosphoprotein Q545N8 Phosphomannomutase 2 Pmm2 5 0,0223 2 5,7414 0,9009 1,2654 5 6,5126 0,2098 P09671 Superoxide dismutase [Mn], Sod2 4 -0,0243 7 6,9302 0,9038 1,0504 14 7,0270 0,4555 mitochondrial Q8VE70 Programmed cell death protein Pdcd10 8 0,0215 4 6,2199 0,9045 1,5807 10 6,9013 0,1973 10 P63037 DnaJ homolog subfamily A Dnaja1 4 -0,0269 2 6,2029 0,9095 -0,2351 4 6,7447 0,5188 member 1 Q5SQX6 Cytoplasmic FMR1-interacting Cyfip2 25 -0,0226 26 7,4329 0,9105 0,2164 23 7,2224 0,9057 protein 2 B1AWX7 Aldehyde dehydrogenase X, Aldh1b1 2 0,0199 2 5,5264 0,9111 NaN 0 NaN 1,0000 mitochondrial B2RUP2 Protein unc-13 homolog D Unc13d 4 0,0198 2 5,5679 0,9117 -0,3392 2 6,0588 0,4335 Q3TKV1 26S proteasome non-ATPase Psmd2 19 0,0158 16 6,9283 0,9127 -0,2907 17 7,3922 0,4905 regulatory subunit 2 P47754 F-actin-capping protein subunit Capza2 7 0,0158 7 7,1583 0,9127 0,8850 11 7,6698 0,5640 alpha-2 Q9D0I9 Arginine--tRNA ligase, Rars 13 -0,0257 9 6,5082 0,9137 -0,3653 16 6,9540 0,4392 cytoplasmic B2RPS1 Ras-related protein Rab-5B Rab5b 6 -0,0253 3 5,6242 0,9152 -0,3336 3 6,3660 0,4378 Q9CWZ3 RNA-binding protein 8A Rbm8a 5 -0,0252 3 6,1671 0,9154 0,8567 6 6,7574 0,4540 B2MWM9 Calreticulin Calr 17 -0,0212 13 7,2545 0,9161 0,0334 16 8,0209 0,7455 O88456 Calpain small subunit 1 Capns1 7 0,0182 5 6,2763 0,9184 0,9594 8 6,7713 0,3811 B2C3G8 Signal transducer and activator of Stat5a 12 0,0178 6 6,2699 0,9202 0,4943 16 7,1704 0,8597 transcription 5A Q9R1P0 Proteasome subunit alpha type-4 Psma4 9 -0,0200 15 7,4767 0,9210 1,2362 10 7,3431 0,3491

P15864 Histone H1.2 Hist1h1c 19 -0,0199 18 8,0197 0,9216 -1,9478 51 9,0208 0,0106 Q80UG5 Septin-9 Sept9 6 0,0136 10 7,0864 0,9239 0,8733 7 7,0766 0,5722 Q3UDM0 MOB kinase activator 1B Mob1b 3 -0,0223 3 6,3349 0,9256 NaN 1 5,8330 1,0000 E9Q8F2 NAD(P) transhydrogenase, Nnt 3 0,0165 3 6,0490 0,9256 NaN 1 5,6846 1,0000 mitochondrial Q8VE47 Ubiquitin-like modifier-activating Uba5 2 0,0164 2 5,7407 0,9262 NaN 1 5,4978 1,0000 enzyme 5 P63242 Eukaryotic translation initiation Eif5a 12 -0,0187 19 7,6666 0,9266 0,8287 16 7,8210 0,6036 factor 5A-1 P47911 60S ribosomal protein L6 Rpl6 8 -0,0186 6 6,8202 0,9270 -0,3341 27 7,5815 0,4603 P14206 40S ribosomal protein SA Rpsa 16 0,0126 21 7,6665 0,9291 1,0890 33 8,1728 0,4320 Q8BJ71 Nuclear pore complex protein Nup93 18 0,0156 10 6,3776 0,9293 -0,6151 17 7,1789 0,2915 Nup93 Q4VAI2 Low molecular weight Acp1 3 0,0156 3 6,0582 0,9293 0,8966 4 6,2518 0,4248 phosphotyrosine protein phosphatase P49722 Proteasome subunit alpha type-2 Psma2 10 -0,0179 21 7,3749 0,9298 1,3654 14 7,5658 0,2852

Q810B6 Ankyrin repeat and FYVE domain- Ankfy1 3 -0,0208 4 6,2500 0,9306 NaN 1 5,7082 1,0000 containing protein 1 P35550 rRNA 2-O-methyltransferase Fbl 8 0,0152 2 5,8877 0,9311 -1,6213 14 7,5255 0,0287 fibrillarin Q542V3 Serine/arginine-rich splicing Srsf4 4 -0,0176 5 6,9060 0,9312 0,2879 6 6,6482 0,9636 factor 4 G3UW94 Splicing factor U2AF 35 kDa U2af1 6 -0,0206 2 5,5552 0,9313 -0,0426 7 6,9179 0,6817 subunit E9Q555 E3 ubiquitin-protein ligase Rnf213 55 -0,0174 62 7,4507 0,9320 -0,5764 17 6,6618 0,2722 RNF213 P23116 Eukaryotic translation initiation Eif3a 47 -0,0173 57 7,8730 0,9324 1,2154 26 7,6660 0,3601 factor 3 subunit A P61028 Ras-related protein Rab-8B Rab8b 6 0,0148 2 6,1257 0,9329 0,7715 5 6,5160 0,5199 P06800 Receptor-type tyrosine-protein Ptprc 44 0,0118 79 8,3613 0,9336 0,7353 45 7,9144 0,6719 phosphatase C Q542F1 Chloride intracellular channel Clic1 21 0,0115 27 7,8401 0,9351 0,4609 53 8,2845 0,8866 protein 1 Q3U741 Probable ATP-dependent RNA Ddx17 12 -0,0166 16 6,9880 0,9353 0,6237 16 7,0053 0,7571 helicase DDX17 Q3U1J4 DNA damage-binding protein 1 Ddb1 25 -0,0164 24 7,2567 0,9359 0,2250 10 7,0275 0,9134 Q9CR16 Peptidyl-prolyl cis-trans Ppid 5 0,0114 8 6,8209 0,9359 0,8725 2 6,2997 0,4423 isomerase D Q3U6P5 Heterogeneous nuclear Hnrnpc 14 -0,0163 17 7,0088 0,9362 -0,8857 21 7,3583 0,1739 ribonucleoproteins C1/C2 P57784 U2 small nuclear Snrpa1 5 -0,0186 7 6,3704 0,9384 0,9572 9 6,5492 0,3826 ribonucleoprotein A Q99PT1 Rho GDP-dissociation inhibitor 1 Arhgdia 15 0,0108 25 7,8690 0,9389 2,6798 30 8,0566 0,0158 P63017 Heat shock cognate 71 kDa Hspa8 43 -0,0155 69 8,6757 0,9396 0,4466 94 8,9135 0,8982 protein Q9QYA2 Mitochondrial import receptor Tomm40 4 -0,0182 4 5,6997 0,9398 -0,7559 4 5,8707 0,1815 subunit TOM40 homolog Q9JIX8 Apoptotic chromatin Acin1 2 0,0129 3 6,0547 0,9408 1,0027 2 5,8303 0,3527 condensation inducer in the nucleus P62267 40S ribosomal protein S23 Rps23 7 0,0104 4 6,6866 0,9411 0,6060 8 7,1712 0,7709 P70429 Ena/VASP-like protein Evl 5 -0,0148 5 7,1072 0,9425 NaN 0 NaN 1,0000 P63158 High mobility group protein B1 Hmgb1 21 0,0099 18 7,9748 0,9434 1,0948 19 8,3054 0,4286 Q3UCV8 Protein FAM105B Fam105b 2 0,0122 3 5,7638 0,9439 NaN 0 NaN 1,0000 Q505L1 Actin-like protein 6A Actl6a 2 -0,0169 2 5,8381 0,9442 NaN 0 NaN 1,0000 O70435 Proteasome subunit alpha type-3 Psma3 14 -0,0142 21 7,4052 0,9452 1,9802 23 7,7002 0,0895

Q4FK49 Inorganic pyrophosphatase Ppa1 8 0,0092 5 6,6421 0,9471 0,9474 10 7,3118 0,5217 Q99L47 Hsc70-interacting protein St13 9 -0,0134 7 7,1658 0,9482 1,0986 7 7,3360 0,4263 O08547 Vesicle-trafficking protein SEC22b Sec22b 7 -0,0156 9 6,4758 0,9489 0,4263 12 6,9431 0,9146

G3X956 FACT complex subunit SPT16 Supt16h 15 -0,0130 12 6,6447 0,9501 0,2511 11 6,7945 1,0000 Q7TMB8 Cytoplasmic FMR1-interacting Cyfip1 18 0,0106 2 5,1146 0,9506 NaN 1 5,1993 1,0000 protein 1 Q61171 Peroxiredoxin-2 Prdx2 8 0,0083 15 7,4900 0,9517 1,2634 11 7,6467 0,3349 Q8BMS1 Trifunctional enzyme subunit Hadha 20 -0,0125 21 7,5093 0,9522 -0,5308 28 7,6486 0,3371 alpha, mitochondrial P11983 T-complex protein 1 subunit Tcp1 18 0,0079 18 7,4289 0,9539 0,4454 11 7,7677 0,8991 alpha Q3TX38 Voltage-dependent anion- Vdac3 12 -0,0120 19 7,3147 0,9541 -0,8276 17 7,7179 0,1956 selective channel protein 3 G3X9I2 Acylamino-acid-releasing enzyme Apeh 7 0,0096 6 6,5323 0,9549 0,8035 5 6,4892 0,4946 Q8C1B7 Septin-11 Sept11 6 0,0096 2 6,2688 0,9549 NaN 0 NaN 1,0000 P42932 T-complex protein 1 subunit Cct8 23 -0,0116 27 7,7231 0,9558 0,5523 13 7,8169 0,8133 theta O70591 Prefoldin subunit 2 Pfdn2 2 -0,0136 4 6,1835 0,9559 0,8108 2 5,9821 0,4889 Q61133 Glutathione S-transferase theta-2 Gstt2 8 0,0091 7 6,3181 0,9573 0,9715 12 6,7953 0,3730

E9PW66 Nucleosome assembly protein 1- Nap1l1 6 0,0072 8 6,6474 0,9577 0,7576 6 7,2160 0,6553 like 1 P80313 T-complex protein 1 subunit eta Cct7 18 -0,0110 20 7,5837 0,9580 0,4446 19 7,9890 0,8998 P51174 Long-chain specific acyl-CoA Acadl 13 -0,0104 14 7,2277 0,9605 -0,1386 11 7,1663 0,6043 dehydrogenase, mitochondrial Q9R1T4 Septin-6 Sept6 7 0,0066 5 6,8149 0,9607 1,3567 7 7,2117 0,2892 Q542J3 Protein tyrosine phosphatase Ptprcap 2 0,0066 4 6,6088 0,9607 1,9082 3 6,3614 0,0405 receptor type C-associated protein Q53WR6 Golgi apparatus protein 1 Glg1 6 -0,0119 6 6,3899 0,9616 -0,3274 3 6,1450 0,4427 E9PUW7 Exportin-7 Xpo7 8 0,0079 8 6,5335 0,9622 -0,1464 6 6,4345 0,5979 P24369 Peptidyl-prolyl cis-trans Ppib 14 0,0060 9 7,1019 0,9637 0,4875 26 7,7040 0,8651 isomerase B P70372 ELAV-like protein 1 Elavl1 5 -0,0112 4 6,3169 0,9643 -0,5896 8 7,1212 0,3048 Q3UIR3 E3 ubiquitin-protein ligase DTX3L Dtx3l 2 -0,0111 3 5,7699 0,9645 0,7351 2 6,1117 0,5495

P62301 40S ribosomal protein S13 Rps13 10 -0,0091 8 7,0066 0,9659 0,3879 22 7,7123 0,9459 Q80UM7 Mannosyl-oligosaccharide Mogs 6 -0,0106 3 6,0224 0,9663 -1,1638 8 6,8630 0,0944 glucosidase Q9CQM8 60S ribosomal protein L21 Rpl21 8 0,0069 7 6,5342 0,9665 -0,4853 14 7,2973 0,3635 Q9WV32 Actin-related protein 2/3 complex Arpc1b 8 -0,0088 10 7,1524 0,9674 0,4926 11 7,7416 0,8610 subunit 1B A2AMV7 F-actin-capping protein subunit Capzb 16 0,0053 15 7,1885 0,9675 0,9619 19 7,7191 0,5121 beta Q8JZN5 Acyl-CoA dehydrogenase family Acad9 4 0,0066 3 6,1150 0,9677 -0,3192 2 5,9735 0,4492 member 9, mitochondrial Q564E8 60S ribosomal protein L4 Rpl4 14 0,0052 11 7,2156 0,9683 -0,9764 17 7,6015 0,1438 Q9CRD0 OCIA domain-containing protein Ociad1 2 -0,0099 2 5,5266 0,9687 -0,1617 2 5,6005 0,5839 1 O88351 Inhibitor of nuclear factor kappa- Ikbkb 2 -0,0093 2 5,5601 0,9708 NaN 0 NaN 1,0000 B kinase subunit beta O88342 WD repeat-containing protein 1 Wdr1 15 0,0046 18 7,5536 0,9713 1,5996 8 7,4677 0,1907 P61211 ADP-ribosylation factor-like Arl1 2 0,0058 2 5,8592 0,9714 -0,3250 4 6,2043 0,4446 protein 1 Q6ZWN5 40S ribosomal protein S9 Rps9 17 -0,0077 9 7,0336 0,9716 -0,4770 37 7,8395 0,3685 Q3U4H0 Microtubule-associated protein Mapre1 9 0,0042 11 6,8011 0,9735 1,3690 9 7,1056 0,2835 RP/EB family member 1 P68033 Actin, alpha cardiac muscle 1 Actc1 27 0,0037 11 7,6631 0,9758 0,2149 7 8,4076 0,9043 Q8VDC3 Cytoplasmic aconitate hydratase Aco1 6 -0,0078 5 5,9294 0,9762 0,0592 4 6,1383 0,7990 Q99JR1 Sideroflexin-1 Sfxn1 11 0,0035 10 6,6237 0,9773 -0,3010 14 7,1921 0,4832 H7BX95 Serine/arginine-rich splicing Srsf1 14 0,0043 7 6,5006 0,9775 -0,0963 21 7,5934 0,6379 factor 1 Q3TH57 Transcription elongation Tcerg1 13 -0,0061 12 6,9698 0,9783 0,9627 10 6,8749 0,5115 regulator 1 A2AHI4 Ribose-phosphate Prps2 11 0,0040 7 6,4695 0,9788 0,4186 10 6,9670 0,9209 pyrophosphokinase O89023 Tripeptidyl-peptidase 1 Tpp1 2 -0,0070 3 6,2060 0,9789 NaN 0 NaN 1,0000 G3X972 Protein Sec24c Sec24c 8 -0,0069 8 6,5067 0,9793 0,3207 6 6,6989 0,9314 B9EHN0 Ubiquitin-like modifier-activating Uba1 48 -0,0058 83 8,3844 0,9796 0,5585 45 8,2077 0,8084 enzyme 1 Q9JKX6 ADP-sugar pyrophosphatase Nudt5 5 -0,0067 5 6,2520 0,9800 -0,4455 8 6,3854 0,3553 P08228 Superoxide dismutase [Cu-Zn] Sod1 7 0,0023 8 7,3827 0,9834 1,8229 10 7,4968 0,1242 P68404-2 Protein kinase C Prkca 2 0,0029 3 5,8738 0,9837 0,2491 2 5,8623 0,9979 Q3T9S3 Protein SET Set 11 -0,0045 13 7,1259 0,9851 0,3824 23 8,0584 0,9504 A2AGJ0 Copine-3 Cpne3 4 0,0025 6 6,5776 0,9855 0,1359 2 6,6519 0,8785 Q8CGC7 Bifunctional glutamate/proline-- Eprs 38 -0,0043 40 7,6555 0,9856 1,1332 12 7,0260 0,4060 tRNA ligase P62242 40S ribosomal protein S8 Rps8 8 0,0019 10 6,6303 0,9857 -0,5645 16 7,3394 0,3183 Q9Z110 Delta-1-pyrroline-5-carboxylate Aldh18a1 8 0,0023 4 5,9304 0,9861 -0,7133 10 6,8607 0,2438 synthase Q3TLP8 Ras-related C3 botulinum toxin Rac1 11 -0,0042 7 7,0838 0,9862 0,4414 9 7,1446 0,9024 substrate 1 B2RXY7 Carbonyl reductase [NADPH] 1 Cbr1 8 0,0017 8 6,8061 0,9864 1,0388 11 7,1182 0,4627 A2A882 Proteasome subunit beta type Psmb2 7 0,0017 9 7,1935 0,9864 1,6372 6 6,9660 0,1780 P11352 Glutathione peroxidase 1 Gpx1 7 -0,0047 9 6,3399 0,9869 -0,3689 5 6,1133 0,4106 Q6PGG2 GEM-interacting protein Gmip 3 0,0017 2 5,5824 0,9886 NaN 1 5,0787 1,0000 Q9D8W5 26S proteasome non-ATPase Psmd12 8 0,0013 10 6,8794 0,9887 0,6545 3 7,1469 0,7332 regulatory subunit 12 Q3TYS2 Uncharacterized protein 4 0,0016 3 6,1836 0,9892 0,0883 8 6,7998 0,8290 C17orf62 homolog F8WI88 PEST proteolytic signal-containing Pcnp 3 0,0016 2 6,0756 0,9892 1,7116 4 6,5553 0,0709 nuclear protein P19253 60S ribosomal protein L13a Rpl13a 14 -0,0033 10 7,0164 0,9900 -0,9382 22 7,7168 0,1560 O55023 Inositol monophosphatase 1 Impa1 5 -0,0036 6 6,3615 0,9908 1,2273 5 6,6272 0,2274 P84099 60S ribosomal protein L19 Rpl19 7 -0,0029 3 6,0827 0,9931 0,4099 8 6,7035 0,8443 O35841 Apoptosis inhibitor 5 Api5 8 -0,0024 6 6,7287 0,9938 0,6543 4 6,8698 0,7334 Q93092 Transaldolase Taldo1 15 -0,0023 21 7,5594 0,9939 1,2787 12 7,5826 0,3271 P39054 Dynamin-2 Dnm2 25 0,0003 21 7,1009 0,9940 1,1907 19 7,3627 0,3735 P68040 Guanine nucleotide-binding Gnb2l1 18 0,0003 30 7,5966 0,9940 0,6044 32 8,0242 0,7722 protein subunit beta-2-like 1 B1AXP1 Eukaryotic translation initiation Eif1ax 4 0,0003 2 6,0722 0,9948 2,4866 7 6,5376 0,0057 factor 1A Q8CHF5 Muscleblind-like protein 1 Mbnl1 6 -0,0024 2 6,2527 0,9950 0,0723 2 6,5021 0,8125 Q3UJB0 Splicing factor 3b, subunit 2 Sf3b2 8 0,0000 11 7,0519 0,9955 NaN 1 6,1369 1,0000 Q8VD31 Tapasin-related protein Tapbpl 3 0,0000 2 5,8972 0,9960 NaN 1 6,3534 1,0000 Q9JLI6 Selenocysteine lyase Scly 2 -0,0001 2 6,4085 0,9965 NaN 1 5,5360 1,0000 P84096 Rho-related GTP-binding protein Rhog 8 -0,0004 5 6,5874 0,9978 2,1720 8 7,1472 0,0581 RhoG O09061 Proteasome subunit beta type-1 Psmb1 8 -0,0005 18 7,5006 0,9982 1,5415 22 7,4490 0,2117 Q3U0M8 Zinc phosphodiesterase ELAC Elac2 3 -0,0012 4 6,2438 0,9990 NaN 1 6,2335 1,0000 protein 2 F8WGT0 Talin-1 Tln1 118 -0,0010 160 8,4195 0,9995 0,3944 79 8,0515 0,9406 B9EI85 Histone H3 Hist2h3b 19 -0,0009 33 8,9434 0,9998 -1,1173 76 9,4845 0,1051 F8WIT2 Annexin Anxa6 57 NaN 0 NaN 1,0000 NaN 1 6,2142 1,0000 P52480-2 Pyruvate kinase isozymes M1/M2 Pkm 37 NaN 0 NaN 1,0000 NaN 1 6,3091 1,0000

Q3UH59 Myosin-10 Myh10 27 NaN 0 NaN 1,0000 -2,7918 2 6,2624 0,0001 E9PXL6 Glyceraldehyde-3-phosphate Gm3200 25 NaN 0 NaN 1,0000 -0,5412 2 6,3124 0,2931 dehydrogenase B2RTK3 Histone H2B Hist1h2bm 22 NaN 0 NaN 1,0000 NaN 1 5,6279 1,0000 Q64475 Histone H2B type 1-B Hist1h2bb 21 NaN 0 NaN 1,0000 NaN 1 6,0739 1,0000 E9Q7Q3 Tropomyosin alpha-3 chain Tpm3 20 NaN 1 5,3368 1,0000 NaN 0 NaN 1,0000 P43277 Histone H1.3 Hist1h1d 18 NaN 0 NaN 1,0000 -1,6257 9 8,0577 0,0283 B3F3T1 Myosin-14 Myh14 17 NaN 0 6,7807 1,0000 NaN 0 NaN 1,0000 E9Q7Z9 Protein Numa1 Numa1 17 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 A2AF67 Dedicator of cytokinesis protein Dock11 13 NaN 0 NaN 1,0000 NaN 1 4,9518 1,0000 11 P42232 Signal transducer and activator of Stat5b 11 NaN 1 5,1995 1,0000 NaN 1 5,3524 1,0000 transcription 5B Q01320 DNA topoisomerase 2-alpha Top2a 11 NaN 1 5,0949 1,0000 NaN 1 5,7434 1,0000 G3UXL2 Ribose-phosphate Prps1l3 10 NaN 0 NaN 1,0000 0,8051 2 6,0879 0,4933 pyrophosphokinase E9PVA3 Gm1966 10 NaN 1 5,6268 1,0000 NaN 1 5,1065 1,0000 P43275 Histone H1.1 Hist1h1a 9 NaN 1 5,7961 1,0000 -1,2984 9 7,1994 0,0681 P11103 Poly [ADP-ribose] polymerase 1 Parp1 9 NaN 1 5,9069 1,0000 NaN 0 NaN 1,0000 G3X9B1 HEAT repeat containing 1 Heatr1 8 NaN 0 NaN 1,0000 -2,4301 7 6,2226 0,0004 B2RWH3 Histone H2A Hist2h2aa1 8 NaN 0 NaN 1,0000 -0,8434 3 6,3653 0,1464 E9Q972 ADP-ribosylation factor 4 Arf4 8 NaN 0 NaN 1,0000 -0,6892 3 6,8303 0,2550 P63087-2 Serine/threonine-protein Ppp1cc 8 NaN 1 5,6806 1,0000 0,5433 4 6,4509 0,7179 phosphatase PP1-gamma catalytic subunit P32261 Antithrombin-III Serpinc1 8 NaN 0 NaN 1,0000 NaN 1 6,8365 1,0000 P84084 ADP-ribosylation factor 5 Arf5 8 NaN 0 NaN 1,0000 NaN 1 5,2799 1,0000 O08528 Hexokinase-2 Hk2 7 NaN 1 5,5143 1,0000 -0,8917 2 5,9172 0,1294 O55201 Transcription elongation factor Supt5h 7 NaN 1 5,4696 1,0000 1,0422 6 6,5317 0,3280 SPT5 Q91V61 Sideroflexin-3 Sfxn3 7 NaN 0 NaN 1,0000 -0,4555 7 6,5461 0,3485 P61027 Ras-related protein Rab-10 Rab10 7 NaN 1 5,2914 1,0000 0,8396 5 6,6834 0,4668 P62874 Guanine nucleotide-binding Gnb1 7 NaN 0 NaN 1,0000 0,5330 2 5,9770 0,7274 protein G(I)/G(S)/G(T) subunit beta-1 Q4VAA1 Ras-related protein Rab-5A Rab5a 7 NaN 1 5,3165 1,0000 0,0520 5 6,5672 0,7916 P21958 Antigen peptide transporter 1 Tap1 7 NaN 1 5,5130 1,0000 0,1000 5 6,3578 0,8411 F6Q8A4 Ribosomal protein S6 kinase Rps6ka1 7 NaN 0 NaN 1,0000 NaN 1 6,0250 1,0000 P62141 Serine/threonine-protein Ppp1cb 7 NaN 1 5,5514 1,0000 NaN 1 5,4515 1,0000 phosphatase PP1-beta catalytic subunit A2APD6 Nucleolar protein 56 Nop56 6 NaN 0 NaN 1,0000 -2,2756 9 6,8608 0,0034 E9Q414 Apolipoprotein B-100 Apob 6 NaN 1 5,5423 1,0000 -4,6330 3 6,2760 0,0000 Q8BH59 Calcium-binding mitochondrial Slc25a12 6 NaN 0 NaN 1,0000 -0,9570 7 6,3294 0,1089 carrier protein Aralar1 P43404 Tyrosine-protein kinase ZAP-70 Zap70 6 NaN 0 NaN 1,0000 -0,7861 8 6,6207 0,1687 A2A9F5 Nuclear migration protein nudC Nudc 6 NaN 1 5,9851 1,0000 0,8868 4 6,5988 0,4318 Q8BP47 Asparagine--tRNA ligase, Nars 6 NaN 0 NaN 1,0000 -0,2595 8 7,1580 0,5128 cytoplasmic A2BDV8 Heterogeneous nuclear Hnrnph2 6 NaN 1 5,5059 1,0000 NaN 0 NaN 1,0000 ribonucleoprotein H2 E9Q035 Protein Gm20425 Gm20425 6 NaN 0 NaN 1,0000 NaN 1 5,5576 1,0000 E9QM66 H-2 class I histocompatibility H2-Q6 6 NaN 0 NaN 1,0000 NaN 1 6,0990 1,0000 antigen, Q7 alpha chain G3UXA6 Polypyrimidine tract-binding Rod1 6 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 protein 3 Q9CWH6 Proteasome subunit alpha type-7- Psma8 6 NaN 0 NaN 1,0000 NaN 1 6,0631 1,0000 like Q61686 Chromobox protein homolog 5 Cbx5 5 NaN 0 NaN 1,0000 -1,3490 6 6,4513 0,0337 A2RS58 Crk-like protein Crkl 5 NaN 1 5,4163 1,0000 -1,3636 4 6,6037 0,0321 Q0VGU0 GTP-binding protein SAR1b Sar1b 5 NaN 0 NaN 1,0000 1,7930 2 5,8300 0,0566 O70400 PDZ and LIM domain protein 1 Pdlim1 5 NaN 1 5,6961 1,0000 1,9328 5 7,4323 0,0990 Q8K2B3 Succinate dehydrogenase Sdha 5 NaN 1 5,4666 1,0000 -0,7963 6 6,5297 0,1646 [ubiquinone] flavoprotein subunit, mitochondrial P97313 DNA-dependent protein kinase Prkdc 5 NaN 0 NaN 1,0000 -0,7689 3 5,6747 0,1759 catalytic subunit F2Z456 NADH-cytochrome b5 reductase Cyb5r3 5 NaN 0 NaN 1,0000 -0,5601 7 6,5909 0,2817 3 Q9DBH5 Vesicular integral-membrane Lman2 5 NaN 1 5,3451 1,0000 -0,4631 4 6,3633 0,3433 protein VIP36 Q9Z0I7 Protein Slfn1 Slfn1 5 NaN 1 5,3391 1,0000 0,9645 4 6,6277 0,3777 P36371 Antigen peptide transporter 2 Tap2 5 NaN 1 5,8730 1,0000 -0,3630 4 7,0517 0,4407 O88879 Apoptotic protease-activating Apaf1 5 NaN 1 5,0203 1,0000 0,7948 6 6,2832 0,5014 factor 1 Q8CAS9 Poly [ADP-ribose] polymerase 9 Parp9 5 NaN 1 5,4927 1,0000 -0,1625 2 6,0226 0,5832 Q62383 Transcription elongation factor Supt6h 5 NaN 0 NaN 1,0000 0,5705 6 6,0325 0,6929 SPT6 Q9R0X4 Acyl-coenzyme A thioesterase 9, Acot9 5 NaN 1 5,8163 1,0000 0,0972 6 6,8678 0,8005 mitochondrial Q8R1V4 Transmembrane emp24 domain- Tmed4 5 NaN 0 NaN 1,0000 0,1845 3 6,0845 0,9296 containing protein 4 E9PVI2 Interferon-g induced GTPase Irgm2 5 NaN 0 NaN 1,0000 NaN 1 5,7665 1,0000 G5E8B8 Fibronectin Fn1 5 NaN 1 6,1228 1,0000 NaN 0 5,7044 1,0000 P50396 Rab GDP dissociation inhibitor Gdi1 5 NaN 0 NaN 1,0000 NaN 1 6,0427 1,0000 alpha A2A4H0 DNA polymerase Pola1 4 NaN 1 5,0366 1,0000 1,4230 3 5,8648 0,1473 Q9QXK7 Cleavage and polyadenylation Cpsf3 4 NaN 0 NaN 1,0000 -0,8097 4 6,3579 0,1592 specificity factor subunit 3 A2AG40 Stomatin-like protein 2 Stoml2 4 NaN 1 5,4094 1,0000 -0,7845 5 6,3272 0,1694 B1AV56 Acyl-protein thioesterase 2 Lypla2 4 NaN 1 5,5517 1,0000 1,2454 6 6,7658 0,2189 Q8C547 HEAT repeat-containing protein Heatr5b 4 NaN 1 5,5816 1,0000 -0,5976 3 5,6483 0,2601 5B A2A4Q1 Interferon-induced 35 kDa Ifi35 4 NaN 0 NaN 1,0000 1,1052 4 6,1573 0,2909 protein homolog P49442 Inositol polyphosphate 1- Inpp1 4 NaN 1 5,9006 1,0000 1,0923 4 6,3535 0,2983 phosphatase P97429 Annexin A4 Anxa4 4 NaN 1 4,9621 1,0000 1,0387 2 6,0681 0,3301 F8WJ61 Paired amphipathic helix protein Sin3a 4 NaN 1 5,4150 1,0000 1,0262 3 6,2398 0,3379 Sin3a Q62388 Serine-protein kinase ATM Atm 4 NaN 0 NaN 1,0000 -0,3744 3 5,6569 0,4065 Q80XN0 D-beta-hydroxybutyrate Bdh1 4 NaN 1 5,5685 1,0000 -0,3649 5 6,3534 0,4137 dehydrogenase, mitochondrial Q9CX86 Heterogeneous nuclear Hnrnpa0 4 NaN 0 NaN 1,0000 0,8065 5 6,2489 0,4922 ribonucleoprotein A0 Q9CXY6 Interleukin enhancer-binding Ilf2 4 NaN 1 5,6677 1,0000 -0,2622 3 6,3130 0,4958 factor 2 P54729 NEDD8 ultimate buster 1 Nub1 4 NaN 1 5,2180 1,0000 -0,2769 5 6,9181 0,5003 P62071 Ras-related protein R-Ras2 Rras2 4 NaN 0 NaN 1,0000 0,7806 5 6,5083 0,5126 Q8BIJ6 Isoleucine--tRNA ligase, Iars2 4 NaN 0 5,6918 1,0000 -0,2356 4 6,1385 0,5184 mitochondrial Q542B0 Exosome complex component Exosc4 4 NaN 1 5,2799 1,0000 0,7085 2 5,8753 0,5717 RRP41 Q7TNC4 Putative RNA-binding protein Luc7l2 4 NaN 0 NaN 1,0000 0,6276 5 6,7348 0,6415 Luc7-like 2 E9Q9L6 Neurobeachin-like protein 2 Nbeal2 4 NaN 0 NaN 1,0000 -0,0285 4 6,8149 0,6934 P35293 Ras-related protein Rab-18 Rab18 4 NaN 0 NaN 1,0000 0,4044 4 6,1216 0,8497 P32883-2 GTPase KRas Kras 4 NaN 0 NaN 1,0000 0,2468 4 6,2167 0,9955 A2ANY6 Midasin Mdn1 4 NaN 1 5,1851 1,0000 NaN 1 4,9781 1,0000 A2AQP0 Myosin-7B Myh7b 4 NaN 0 NaN 1,0000 NaN 1 6,1546 1,0000 B2RVP5 Histone H2A H2afv 4 NaN 1 5,2082 1,0000 NaN 1 6,0586 1,0000 Q4FK36 Destrin Dstn 4 NaN 1 5,0035 1,0000 NaN 1 5,5170 1,0000 Q5SYD0 Unconventional myosin-Id Myo1d 4 NaN 0 NaN 1,0000 NaN 1 6,1675 1,0000 Q9DBB4 N-alpha-acetyltransferase 16, Naa16 4 NaN 1 5,4927 1,0000 NaN 1 6,2548 1,0000 NatA auxiliary subunit P11087 Collagen alpha-1(I) chain Col1a1 3 NaN 1 6,2711 1,0000 3,1159 3 7,5457 0,0042 P97315 Cysteine and glycine-rich protein Csrp1 3 NaN 1 5,7963 1,0000 2,8872 3 6,4041 0,0011 1 Q6NS46 Protein RRP5 homolog Pdcd11 3 NaN 1 5,5428 1,0000 -1,5414 2 5,4937 0,0174 D0QMC3 Myeloid cell nuclear Mndal 3 NaN 1 5,1522 1,0000 -1,6665 5 6,2410 0,0109 differentiation antigen-like protein Q9DCT1 1,5-anhydro-D-fructose reductase Akr1e2 3 NaN 0 NaN 1,0000 -1,6797 2 5,8892 0,0104

O35326 Serine/arginine-rich splicing Srsf5 3 NaN 0 NaN 1,0000 -2,2547 3 6,0550 0,0009 factor 5 Q8BVK9 Sp110 nuclear body protein Sp110 3 NaN 1 5,6099 1,0000 -3,2698 2 5,7602 0,0000 Q64727 Vinculin Vcl 3 NaN 1 5,4227 1,0000 -4,2091 3 6,0298 0,0000 G3UWG9 60S ribosomal protein L29 Gm5561 3 NaN 0 NaN 1,0000 -1,1754 4 6,7142 0,0584 E9PWT1 Transformation/transcription Trrap 3 NaN 1 5,3459 1,0000 -1,1708 3 5,6251 0,0592 domain-associated protein Q6DFW4 Nucleolar protein 58 Nop58 3 NaN 1 5,2189 1,0000 -1,3459 4 7,2559 0,0604 Q5SUR3 S-phase kinase-associated protein Skp1a 3 NaN 1 5,1933 1,0000 1,6766 4 5,9250 0,0780 1 Q9QZE7 Translin-associated protein X Tsnax 3 NaN 0 NaN 1,0000 1,6090 2 6,1756 0,0931 P11438 Lysosome-associated membrane Lamp1 3 NaN 1 6,2749 1,0000 -0,9045 2 6,4921 0,1252 glycoprotein 1 A2BDX1 Dolichol-phosphate Dpm1 3 NaN 0 NaN 1,0000 -0,7918 4 6,0908 0,1664 mannosyltransferase B9EHY2 CAAX prenyl protease 1 homolog Zmpste24 3 NaN 0 NaN 1,0000 -0,7761 2 5,7577 0,1729

Q64518 Sarcoplasmic/endoplasmic Atp2a3 3 NaN 1 5,3649 1,0000 -0,7661 3 6,2598 0,1771 reticulum calcium ATPase 3 Q9JKF7 39S ribosomal protein L39, Mrpl39 3 NaN 0 NaN 1,0000 -0,7209 3 5,5557 0,1971 mitochondrial Q3UYX6 Serine/arginine-rich splicing Srsf10 3 NaN 0 NaN 1,0000 -0,7078 5 6,3806 0,2032 factor 10 Q9D0L7 Armadillo repeat-containing Armc10 3 NaN 1 5,4783 1,0000 1,2448 3 6,0868 0,2192 protein 10 P68037 Ubiquitin-conjugating enzyme E2 Ube2l3 3 NaN 1 5,7358 1,0000 1,4311 4 7,3261 0,2559 L3 Q9QZ88-2 Vacuolar protein sorting- Vps29 3 NaN 1 5,3596 1,0000 1,1608 5 6,5010 0,2607 associated protein 29 P37040 NADPH--cytochrome P450 Por 3 NaN 0 NaN 1,0000 -0,5926 2 5,6527 0,2629 reductase Q569Y6 Ubiquitin-conjugating enzyme E2 Ube2v1 3 NaN 0 NaN 1,0000 1,4042 5 7,0928 0,2677 variant 1 Q4FK57 ERO1-like protein alpha Ero1l 3 NaN 1 5,3002 1,0000 -0,5735 2 6,1851 0,2739 P27046 Alpha-mannosidase 2 Man2a1 3 NaN 1 5,2732 1,0000 -0,5035 2 5,7580 0,3166 P67871 Casein kinase II subunit beta Csnk2b 3 NaN 1 5,2028 1,0000 -0,4729 3 6,3685 0,3367 Q3TMZ1 Pyrroline-5-carboxylate reductase Pycr2 3 NaN 1 5,1089 1,0000 -0,4599 2 6,0365 0,3454

O09131 Glutathione S-transferase omega- Gsto1 3 NaN 1 5,7638 1,0000 1,0041 5 6,4093 0,3518 1 Q9QYB5 Gamma-adducin Add3 3 NaN 0 NaN 1,0000 1,0030 4 6,4276 0,3525 O35604 Niemann-Pick C1 protein Npc1 3 NaN 1 6,0533 1,0000 -0,4494 4 6,2953 0,3526 Q3V2H3 Sorting nexin-12 Snx12 3 NaN 1 5,5874 1,0000 0,9864 4 6,3306 0,3633 Q5SWN2 Replication protein A 70 kDa DNA- Rpa1 3 NaN 1 5,4264 1,0000 -0,3468 4 6,3793 0,4276 binding subunit Q9WUM5 Succinyl-CoA ligase [ADP/GDP- Suclg1 3 NaN 0 NaN 1,0000 -0,2974 4 6,7513 0,4667 forming] subunit alpha, mitochondrial Q8BWF2 GTPase IMAP family member 5 Gimap5 3 NaN 1 5,3251 1,0000 -0,2690 4 6,3460 0,4901 D3Z6Q3 Forkhead box protein P1 Foxp1 3 NaN 1 5,4179 1,0000 -0,2461 2 6,1369 0,5094 Q9EP69 Phosphatidylinositide Sacm1l 3 NaN 1 5,2893 1,0000 -0,2430 6 6,7816 0,5120 phosphatase SAC1 Q6ZQ77 Huntingtin-interacting protein 1- Hip1r 3 NaN 1 5,6508 1,0000 -0,2294 2 5,7491 0,5237 related protein Q61074 Protein phosphatase 1G Ppm1g 3 NaN 1 5,5488 1,0000 0,7363 4 6,2765 0,5485 Q76LV0 Glutathione peroxidase Gpx4 3 NaN 1 5,6021 1,0000 -0,1976 6 6,4638 0,5516 Q9QXB9 Developmentally-regulated GTP- Drg2 3 NaN 0 NaN 1,0000 -0,1945 4 6,1964 0,5543 binding protein 2 Q9D880 Mitochondrial import inner Timm50 3 NaN 0 NaN 1,0000 -0,1800 3 6,3665 0,5673 membrane translocase subunit TIM50 Q9D071 MMS19 nucleotide excision Mms19 3 NaN 0 NaN 1,0000 -0,1673 3 5,9625 0,5787 repair protein homolog Q8VCG1 Deoxyuridine triphosphatase Dut 3 NaN 0 NaN 1,0000 0,6594 4 6,0819 0,6137 Q61550 Double-strand-break repair Rad21 3 NaN 1 5,2800 1,0000 0,6511 4 6,1708 0,6208 protein rad21 homolog Q9WTP7 GTP:AMP phosphotransferase, Ak3 3 NaN 0 NaN 1,0000 -0,1200 4 6,2308 0,6224 mitochondrial Q9CQR6 Serine/threonine-protein Ppp6c 3 NaN 1 5,4266 1,0000 0,6286 3 6,3536 0,6406 phosphatase 6 catalytic subunit P62996 Transformer-2 protein homolog Tra2b 3 NaN 1 5,5481 1,0000 0,6263 3 6,0978 0,6427 beta Q9D6J6 NADH dehydrogenase Ndufv2 3 NaN 0 NaN 1,0000 -0,0836 4 6,4019 0,6570 [ubiquinone] flavoprotein 2, mitochondrial Q8C0E2 Vacuolar protein sorting- Vps26b 3 NaN 1 5,7840 1,0000 0,5905 3 6,4063 0,6747 associated protein 26B Q9D0B0 Serine/arginine-rich splicing Srsf9 3 NaN 0 NaN 1,0000 0,0052 3 5,5476 0,7442 factor 9 B1AUN1 Wiskott-Aldrich syndrome protein Wasf2 3 NaN 0 NaN 1,0000 0,4770 4 6,1426 0,7800 family member 2 P30416 Peptidyl-prolyl cis-trans Fkbp4 3 NaN 1 6,1468 1,0000 0,0463 2 6,6657 0,7858 isomerase FKBP4 Q9DCJ5 NADH dehydrogenase Ndufa8 3 NaN 0 NaN 1,0000 0,0573 3 6,4051 0,7970 [ubiquinone] 1 alpha subcomplex subunit 8 Q9CYG7 Mitochondrial import receptor Tomm34 3 NaN 0 NaN 1,0000 0,0826 4 6,4695 0,8230 subunit TOM34 Q3UZG4 Aminoacyl tRNA synthase Aimp1 3 NaN 0 NaN 1,0000 0,0865 3 6,0901 0,8271 complex-interacting multifunctional protein 1 P47811 Mitogen-activated protein kinase Mapk14 3 NaN 1 5,3115 1,0000 0,4168 2 6,3940 0,8376 14 Q9DCS9 NADH dehydrogenase Ndufb10 3 NaN 0 NaN 1,0000 0,1702 3 5,8519 0,9145 [ubiquinone] 1 beta subcomplex subunit 10 E9Q342 Guanylate-binding protein 10 Gbp6 3 NaN 1 5,2362 1,0000 0,3164 5 6,3106 0,9357 B2RXQ8 WD repeat-containing protein 82 Wdr82 3 NaN 0 NaN 1,0000 0,2968 2 6,1680 0,9549

P56960 Exosome component 10 Exosc10 3 NaN 1 5,0358 1,0000 0,2125 2 6,0591 0,9592 Q8VHN8-2 Protein syndesmos Nudt16l1 3 NaN 1 4,9790 1,0000 0,2656 2 5,6227 0,9857 E0CXZ9 Voltage-gated potassium channel Kcnab2 3 NaN 0 NaN 1,0000 0,2453 4 6,2861 0,9938 subunit beta-2 P42669 Transcriptional activator protein Pura 3 NaN 1 5,3391 1,0000 0,2548 3 6,3878 0,9963 Pur-alpha A2ASS6 Titin Ttn 3 NaN 1 7,9250 1,0000 NaN 1 7,2878 1,0000 O08807 Peroxiredoxin-4 Prdx4 3 NaN 0 NaN 1,0000 NaN 1 4,9926 1,0000 Q9R0P4 Small acidic protein Smap 3 NaN 0 NaN 1,0000 NaN 0 4,8967 1,0000 E9PUJ6 Probable E3 ubiquitin-protein Mycbp2 3 NaN 1 6,2774 1,0000 NaN 1 4,9095 1,0000 ligase MYCBP2 E9Q0F0 Protein Krt78 Krt78 3 NaN 0 NaN 1,0000 NaN 1 6,5107 1,0000 Q01405 Protein transport protein Sec23A Sec23a 3 NaN 0 NaN 1,0000 NaN 1 5,1583 1,0000 E9Q5W5 Zinc finger ZZ-type and EF-hand Zzef1 3 NaN 0 NaN 1,0000 NaN 1 6,3149 1,0000 domain-containing protein 1 E9Q753 GTPase NRas Nras 3 NaN 1 5,7203 1,0000 NaN 0 NaN 1,0000 Q99PP7 E3 ubiquitin-protein ligase Trim33 3 NaN 1 5,1748 1,0000 NaN 1 5,0668 1,0000 TRIM33 F7BX26 Serine/threonine-protein Ppp5c 3 NaN 1 5,6546 1,0000 NaN 1 6,1521 1,0000 phosphatase G3UYI5 Protein mago nashi homolog 2 Magohb 3 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 G5E835 DNA helicase B Helb 3 NaN 1 5,0999 1,0000 NaN 1 5,2034 1,0000 G5E896 Enhancer of mRNA-decapping Edc4 3 NaN 1 5,2700 1,0000 NaN 1 6,0009 1,0000 protein 4 P10833 Ras-related protein R-Ras Rras 3 NaN 0 NaN 1,0000 NaN 1 5,1431 1,0000 Q8JZZ5 Phosphatidylinositol transfer Pitpnb 3 NaN 0 NaN 1,0000 NaN 1 5,7221 1,0000 protein beta isoform Q6R0H7 Guanine nucleotide-binding Gnas 3 NaN 1 5,4829 1,0000 NaN 1 5,6448 1,0000 protein G(s) subunit alpha isoforms XLas Q00623 Apolipoprotein A-I Apoa1 3 NaN 0 NaN 1,0000 NaN 1 5,6617 1,0000 Q05BF3 Ctsd protein Ctsd 3 NaN 1 4,7197 1,0000 NaN 0 NaN 1,0000 Q3TKQ3 Exosome complex component Exosc2 3 NaN 1 5,2883 1,0000 NaN 1 5,1983 1,0000 RRP4 Q5QNT9 Nuclear pore complex protein Nup88 3 NaN 0 NaN 1,0000 NaN 1 5,5878 1,0000 Nup88 Q8R0G9 Nuclear pore complex protein Nup133 3 NaN 1 5,6018 1,0000 NaN 0 NaN 1,0000 Nup133 G3X9H5 Huntingtin Htt 2 NaN 1 5,3887 1,0000 3,0844 3 6,4978 0,0005 Q5SWZ0 Phosphoribosyl pyrophosphate Prpsap2 2 NaN 0 NaN 1,0000 2,1221 2 5,8777 0,0207 synthase-associated protein 2 E9QK83 Small subunit processome Utp20 2 NaN 0 NaN 1,0000 -1,3989 3 5,8608 0,0286 component 20 homolog D3YXN0 AP-1 complex subunit sigma-1A Ap1s1 2 NaN 0 NaN 1,0000 -1,5331 3 6,1916 0,0179 Q542D9 Transferrin receptor protein 1 Tfrc 2 NaN 0 NaN 1,0000 -1,6867 2 5,8450 0,0101 Q9QXL1 Kinesin-like protein KIF21B Kif21b 2 NaN 0 NaN 1,0000 -2,1433 3 6,0411 0,0015 Q04750 DNA topoisomerase 1 Top1 2 NaN 1 5,4312 1,0000 -4,4059 5 6,7987 0,0000 P01942 Hemoglobin subunit alpha Hba 2 NaN 0 NaN 1,0000 -4,4102 6 6,5214 0,0000 D3YW52 Alpha-2-macroglobulin Pzp 2 NaN 1 6,0658 1,0000 -4,5570 2 5,9325 0,0000 P07724 Serum albumin Alb 2 NaN 0 7,2580 1,0000 -6,5758 2 7,3564 0,0000 Q6P2B1-2 Transportin-3 Tnpo3 2 NaN 0 NaN 1,0000 -1,1847 2 5,9582 0,0567 Q9DBS1 Transmembrane protein 43 Tmem43 2 NaN 0 NaN 1,0000 -1,1309 4 6,6716 0,0667 Q6ZPR5 Sphingomyelin Smpd4 2 NaN 0 NaN 1,0000 -1,0193 2 5,7892 0,0918 phosphodiesterase 4 Q07235 Glia-derived nexin Serpine2 2 NaN 0 NaN 1,0000 -0,9990 2 6,3792 0,0971 A2ALF2 DnaJ homolog subfamily C Dnajc8 2 NaN 0 NaN 1,0000 -0,9819 3 6,4510 0,1018 member 8 Q8BV13 COP9 signalosome complex Cops7b 2 NaN 1 6,0350 1,0000 -0,9816 3 6,5639 0,1019 subunit 7b B1AT82 Phosphoribosyl pyrophosphate Prpsap1 2 NaN 0 NaN 1,0000 1,4112 2 5,9114 0,1515 synthase-associated protein 1 P03888 NADH-ubiquinone Mtnd1 2 NaN 0 NaN 1,0000 -0,8127 2 5,6541 0,1580 oxidoreductase chain 1 Q8BG13 Putative RNA-binding protein 3 Rbm3 2 NaN 1 5,4178 1,0000 1,6738 2 6,9960 0,1662 Q9CRB9 Coiled-coil-helix-coiled-coil-helix Chchd3 2 NaN 0 NaN 1,0000 -0,7508 3 5,9211 0,1837 domain-containing protein 3, mitochondrial Q8R0W0 Epiplakin Eppk1 2 NaN 0 NaN 1,0000 1,3038 2 6,5899 0,1931 O88696 Putative ATP-dependent Clp Clpp 2 NaN 0 NaN 1,0000 -0,5933 2 5,6387 0,2625 protease proteolytic subunit, mitochondrial B1AUP4 UPF0368 protein Cxorf26 2610029G23Rik 2 NaN 1 5,4279 1,0000 1,1454 2 5,9962 0,2688 homolog P35294 Ras-related protein Rab-19 Rab19 2 NaN 0 NaN 1,0000 -0,5518 3 5,6937 0,2867 Q9D104 Signal recognition particle 19 kDa Srp19 2 NaN 0 NaN 1,0000 -0,5336 2 5,4747 0,2977 protein B9EJX8 Peptidyl-prolyl cis-trans Ppil1 2 NaN 1 5,7087 1,0000 1,0613 2 6,0290 0,3164 isomerase Q921G6 Leucine-rich repeat and calponin Lrch4 2 NaN 0 NaN 1,0000 1,0598 2 5,4954 0,3173 homology domain-containing protein 4 A2CFA7 Proteasome subunit beta type Psmb6 2 NaN 1 5,7958 1,0000 1,0401 4 6,5877 0,3293 E9Q474 Protein Akap13 Akap13 2 NaN 1 5,6731 1,0000 -0,4750 4 6,0548 0,3353 P40630 Transcription factor A, Tfam 2 NaN 0 NaN 1,0000 -0,4636 3 6,0118 0,3429 mitochondrial Q8CHP8 Phosphoglycolate phosphatase Pgp 2 NaN 0 NaN 1,0000 1,0145 3 6,2173 0,3452 Q05117 Tartrate-resistant acid Acp5 2 NaN 0 NaN 1,0000 1,0129 2 5,6787 0,3462 phosphatase type 5 A6H667 Protein kinase C theta type Prkcq 2 NaN 1 5,2505 1,0000 -0,4472 2 5,9418 0,3541 Q543K2 Copper chaperone for superoxide Ccs 2 NaN 1 4,8578 1,0000 -0,4351 2 5,6348 0,3625 dismutase Q8BTX9 Inactive hydroxysteroid Hsdl1 2 NaN 0 NaN 1,0000 -0,4257 3 6,1149 0,3691 dehydrogenase-like protein 1 Q8K183 Pyridoxal kinase Pdxk 2 NaN 1 4,7215 1,0000 0,9736 2 5,6993 0,3717 Q571J1 Cytohesin-4 Cyth4 2 NaN 0 NaN 1,0000 -0,4084 2 5,8956 0,3815 Q9CR68 Cytochrome b-c1 complex Uqcrfs1 2 NaN 1 5,5295 1,0000 -0,3996 2 5,9915 0,3879 subunit Rieske, mitochondrial Q6PGB6-4 N-alpha-acetyltransferase 50 Naa50 2 NaN 0 NaN 1,0000 0,9480 3 5,9158 0,3888 Q8R0J2 Mannose-P-dolichol utilization Mpdu1 2 NaN 0 NaN 1,0000 -0,3689 3 6,3405 0,4107 defect 1 protein Q8C739 Protein FAM110B Fam110b 2 NaN 0 NaN 1,0000 0,9011 3 6,6481 0,4216 Q9JL16 Interferon-stimulated gene 20 Isg20 2 NaN 0 NaN 1,0000 0,8963 2 5,6008 0,4250 kDa protein Q8QZS1 3-hydroxyisobutyryl-CoA Hibch 2 NaN 1 5,0876 1,0000 0,8948 4 6,0799 0,4260 hydrolase, mitochondrial P70302 Stromal interaction molecule 1 Stim1 2 NaN 1 5,2495 1,0000 0,8752 2 5,7622 0,4403 P50171-2 Estradiol 17-beta-dehydrogenase Hsd17b8 2 NaN 0 NaN 1,0000 -0,3266 3 5,8052 0,4433 8 O70492 Sorting nexin-3 Snx3 2 NaN 0 NaN 1,0000 -0,3251 2 5,7955 0,4445 Q9D1M4 Eukaryotic translation elongation Eef1e1 2 NaN 0 NaN 1,0000 -0,3024 4 6,2001 0,4627 factor 1 epsilon-1 O89079 Coatomer subunit epsilon Cope 2 NaN 0 NaN 1,0000 -0,2881 2 6,1974 0,4743 Q4VBG1 Probable ATP-dependent RNA Ddx47 2 NaN 0 NaN 1,0000 -0,2755 2 5,9322 0,4847 helicase DDX47 H9KV00 Protein SON Son 2 NaN 0 NaN 1,0000 -0,2677 2 6,7791 0,4912 A2A7Z2 Thioredoxin domain-containing Txndc12 2 NaN 1 5,2931 1,0000 -0,2533 2 5,7331 0,5033 protein 12 P50295 Arylamine N-acetyltransferase 2 Nat2 2 NaN 0 NaN 1,0000 -0,2477 2 5,7297 0,5081 P23475 X-ray repair cross-complementing Xrcc6 2 NaN 0 NaN 1,0000 -0,2301 2 5,6158 0,5231 protein 6 O88673 Diacylglycerol kinase alpha Dgka 2 NaN 1 5,3272 1,0000 -0,2203 2 5,7109 0,5316 Q3UZ39 Leucine-rich repeat flightless- Lrrfip1 2 NaN 0 NaN 1,0000 0,7494 2 6,2755 0,5378 interacting protein 1 G5E8I8 Calcium homeostasis Cherp 2 NaN 0 NaN 1,0000 -0,2065 2 5,8869 0,5437 endoplasmic reticulum protein Q9CRT8 Exportin-T Xpot 2 NaN 0 NaN 1,0000 -0,1935 2 5,7382 0,5552 Q8BSU7 MOB kinase activator 3A Mob3a 2 NaN 0 NaN 1,0000 0,7260 2 5,8908 0,5570 Q8VCN5 Cystathionine gamma-lyase Cth 2 NaN 0 NaN 1,0000 -0,1673 2 5,9102 0,5788 O88545 COP9 signalosome complex Cops6 2 NaN 0 NaN 1,0000 0,6827 2 6,0024 0,5936 subunit 6 Q91VK1 Basic leucine zipper and W2 Bzw2 2 NaN 0 NaN 1,0000 0,6060 2 5,8820 0,6608 domain-containing protein 2 Q5EBH1 Ras association domain- Rassf5 2 NaN 1 5,4577 1,0000 0,6015 3 6,0733 0,6648 containing protein 5 F8WIS7 Nesprin-1 Syne1 2 NaN 0 NaN 1,0000 -0,0479 2 6,7790 0,6916 Q80ZV0 Ribonuclease H2 subunit B Rnaseh2b 2 NaN 0 NaN 1,0000 0,5587 3 6,2615 0,7037 F8WGD1 Ran GTPase-activating protein 1 Rangap1 2 NaN 1 5,2039 1,0000 0,5485 3 5,9530 0,7130 P47738 Aldehyde dehydrogenase, Aldh2 2 NaN 1 5,2832 1,0000 -0,0202 2 6,1852 0,7189 mitochondrial Q8BY89 Choline transporter-like protein 2 Slc44a2 2 NaN 0 NaN 1,0000 0,0256 2 5,7262 0,7648

Q5SUS9 RNA-binding protein EWS Ewsr1 2 NaN 0 NaN 1,0000 0,0338 3 6,4175 0,7731 E9PV22 Leucine-rich repeat-containing Lrrc47 2 NaN 0 NaN 1,0000 0,0390 2 6,0771 0,7784 protein 47 Q8BYH7 TBC1 domain family member 17 Tbc1d17 2 NaN 0 NaN 1,0000 0,0424 2 5,6222 0,7818 Q6ZQ29-2 Serine/threonine-protein kinase Taok2 2 NaN 0 NaN 1,0000 0,0457 2 6,1716 0,7852 TAO2 A2A7S7 Tyrosine--tRNA ligase, Yars 2 NaN 0 NaN 1,0000 0,4543 2 6,4282 0,8016 cytoplasmic Q04736 Tyrosine-protein kinase Yes Yes1 2 NaN 0 NaN 1,0000 0,0667 2 6,0746 0,8067 P70697 Uroporphyrinogen decarboxylase Urod 2 NaN 0 NaN 1,0000 0,0809 3 6,0460 0,8214

O35855 Branched-chain-amino-acid Bcat2 2 NaN 1 4,8134 1,0000 0,0861 2 6,3110 0,8267 aminotransferase, mitochondrial

Q9CPQ3 Mitochondrial import receptor Tomm22 2 NaN 1 5,7311 1,0000 0,0944 2 6,0210 0,8353 subunit TOM22 homolog O55022 Membrane-associated Pgrmc1 2 NaN 0 NaN 1,0000 0,1069 3 6,1601 0,8482 progesterone receptor component 1 P28352 DNA-(apurinic or apyrimidinic Apex1 2 NaN 0 NaN 1,0000 0,4039 4 6,2698 0,8501 site) lyase Q922Y1 UBX domain-containing protein 1 Ubxn1 2 NaN 1 5,4471 1,0000 0,4034 2 6,0442 0,8506

P04235 T-cell surface glycoprotein CD3 Cd3d 2 NaN 0 NaN 1,0000 0,3985 3 6,5251 0,8554 delta chain Q9D8Y7 Tumor necrosis factor alpha- Tnfaip8l2 2 NaN 1 7,1522 1,0000 0,3974 2 5,6418 0,8565 induced protein 8-like protein 2 Q8CG29 Unconventional myosin-Ie Myo1f 2 NaN 0 NaN 1,0000 0,3884 2 5,6671 0,8652 B1AXY3 WD40 repeat-containing protein Smu1 2 NaN 1 5,3473 1,0000 0,1767 3 6,9986 0,8704 SMU1 P97370 Sodium/potassium-transporting Atp1b3 2 NaN 1 6,0564 1,0000 0,1293 2 6,6333 0,8717 ATPase subunit beta-3 A0MNP4 WD repeat-containing protein 61 Wdr61 2 NaN 0 NaN 1,0000 0,3791 2 5,8859 0,8743

Q3UGB5 DAZ-associated protein 1 Dazap1 2 NaN 1 5,5386 1,0000 0,3730 2 6,3037 0,8802 Q9CY97 RNA polymerase II subunit A C- Ssu72 2 NaN 1 4,9780 1,0000 0,3704 2 5,7125 0,8827 terminal domain phosphatase SSU72 Q9CQA1 Trafficking protein particle Trappc5 2 NaN 0 NaN 1,0000 0,3659 2 5,6468 0,8871 complex subunit 5 Q9ESE1 Lipopolysaccharide-responsive Lrba 2 NaN 0 NaN 1,0000 0,1665 2 5,8022 0,9106 and beige-like anchor protein Q8K2I4 Beta-mannosidase Manba 2 NaN 0 NaN 1,0000 0,3410 2 5,7994 0,9115 P83741-3 Serine/threonine-protein kinase Wnk1 2 NaN 1 5,2953 1,0000 0,3271 2 5,7471 0,9251 WNK1 Q61790 Lymphocyte activation gene 3 Lag3 2 NaN 0 NaN 1,0000 0,1979 2 5,6404 0,9437 protein Q91YE6 Importin-9 Ipo9 2 NaN 0 NaN 1,0000 0,2978 2 5,8580 0,9539 Q9WV80 Sorting nexin-1 Snx1 2 NaN 0 NaN 1,0000 0,2883 4 6,0184 0,9633 Q63829 COMM domain-containing Commd3 2 NaN 0 NaN 1,0000 0,2705 2 5,3834 0,9809 protein 3 Q3TSR1 Vacuolar protein-sorting- Vps36 2 NaN 0 NaN 1,0000 0,2449 2 6,0807 0,9934 associated protein 36 Q8BTS3 Guanylate-binding protein 9 Gbp9 2 NaN 1 5,1357 1,0000 0,2525 3 5,8469 0,9986 A2A432 Cullin-4B Cul4b 2 NaN 1 5,1011 1,0000 NaN 1 6,2663 1,0000 A2A6C8 Chromobox protein homolog 1 Cbx1 2 NaN 0 NaN 1,0000 NaN 1 5,9354 1,0000 A2A6S3 NADPH:adrenodoxin Fdxr 2 NaN 0 NaN 1,0000 NaN 1 5,3428 1,0000 oxidoreductase, mitochondrial A2AA49 Guanine nucleotide-binding Gna13 2 NaN 0 NaN 1,0000 NaN 1 5,7398 1,0000 protein subunit alpha-13 Q8BMA6 Signal recognition particle 68 kDa Srp68 2 NaN 1 4,7504 1,0000 NaN 1 5,1512 1,0000 protein A2AE27 AMP deaminase 2 Ampd2 2 NaN 1 5,1254 1,0000 NaN 1 5,3166 1,0000 A2ALM8 B-cell receptor-associated protein Bcap31 2 NaN 1 5,1303 1,0000 NaN 0 NaN 1,0000 31 Q80TY0 Formin-binding protein 1 Fnbp1 2 NaN 1 5,0396 1,0000 NaN 1 5,3152 1,0000 Q60591 Nuclear factor of activated T- Nfatc2 2 NaN 1 5,1207 1,0000 NaN 1 5,3863 1,0000 cells, cytoplasmic 2 A2AU91 Tumor suppressor p53-binding Trp53bp1 2 NaN 0 NaN 1,0000 NaN 1 5,1704 1,0000 protein 1 Q8VHM5 Heterogeneous nuclear Hnrnpr 2 NaN 0 NaN 1,0000 NaN 1 5,1762 1,0000 ribonucleoprotein R A2AWH9 Probable methylthioribulose-1- Apip 2 NaN 1 5,2880 1,0000 NaN 1 4,9354 1,0000 phosphate dehydratase A3KGK6 Copine-1 Cpne1 2 NaN 0 NaN 1,0000 NaN 1 6,1523 1,0000 A8DUK4 Hemoglobin subunit beta-1 Hbb-b1 2 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 B1AU43 Cyclin-dependent kinase-like 3 Cdkl3 2 NaN 0 NaN 1,0000 NaN 1 5,4088 1,0000 E9PV45 Ubiquitin carboxyl-terminal Usp24 2 NaN 0 NaN 1,0000 NaN 0 4,3699 1,0000 hydrolase B1AZI6 THO complex subunit 2 Thoc2 2 NaN 1 5,3816 1,0000 NaN 1 5,5091 1,0000 B2RPS7 Short transient receptor potential Trpc1 2 NaN 0 NaN 1,0000 NaN 1 6,2412 1,0000 channel 1 B2RQV1 N-alpha-acetyltransferase 25, Naa25 2 NaN 1 5,3353 1,0000 NaN 1 5,4225 1,0000 NatB auxiliary subunit D3YUM8 Proteasome subunit beta type Gm4950 2 NaN 0 NaN 1,0000 NaN 0 5,4184 1,0000 Q9CY66 H/ACA ribonucleoprotein Gar1 2 NaN 0 NaN 1,0000 NaN 1 5,0785 1,0000 complex subunit 1 Q63844 Mitogen-activated protein kinase Mapk3 2 NaN 0 NaN 1,0000 NaN 1 5,8567 1,0000 3 D3Z7E3 Protein Dok-7 Dok7 2 NaN 1 5,0847 1,0000 NaN 0 NaN 1,0000 P58281-2 Dynamin-like 120 kDa protein, Opa1 2 NaN 1 6,2267 1,0000 NaN 0 NaN 1,0000 mitochondrial E0CZ42 Otoferlin Fer1l6 2 NaN 0 NaN 1,0000 NaN 1 6,5456 1,0000 P48453 Serine/threonine-protein Ppp3cb 2 NaN 1 5,1960 1,0000 NaN 0 NaN 1,0000 phosphatase 2B catalytic subunit beta isoform E9PV41 Protein diaphanous homolog 1 Diap1 2 NaN 1 6,7592 1,0000 NaN 1 5,0412 1,0000 F8WHQ6 Poly(A) polymerase alpha Papola 2 NaN 1 5,1140 1,0000 NaN 1 5,1554 1,0000 E9Q557 Desmoplakin Dsp 2 NaN 0 5,0914 1,0000 NaN 0 4,8040 1,0000 Q3THS6 S-adenosylmethionine synthase Mat2a 2 NaN 1 6,0747 1,0000 NaN 1 6,2160 1,0000 isoform type-2 Q8BIK4-2 Dedicator of cytokinesis protein 9 Dock9 2 NaN 0 NaN 1,0000 NaN 1 5,7805 1,0000

O09126 Semaphorin-4D Sema4d 2 NaN 1 5,1584 1,0000 NaN 0 NaN 1,0000 E9Q4F5 Clip1 2 NaN 1 7,0198 1,0000 NaN 1 6,6250 1,0000 E9Q4S3 Ninein Nin 2 NaN 1 6,3099 1,0000 NaN 0 NaN 1,0000 F8VQC1 Protein Srp72 Srp72 2 NaN 1 5,5803 1,0000 NaN 1 5,7413 1,0000 E9QKE4 Rab3 GTPase-activating protein Rab3gap2 2 NaN 1 4,8443 1,0000 NaN 0 NaN 1,0000 non-catalytic subunit E9QN99 Abhydrolase domain-containing Abhd14b 2 NaN 1 5,0490 1,0000 NaN 1 5,1721 1,0000 protein 14B Q70FJ1 A-kinase anchor protein 9 Akap9 2 NaN 1 5,8734 1,0000 NaN 1 6,2619 1,0000 Q3TE40 Replication protein A 32 kDa Rpa2 2 NaN 1 5,6028 1,0000 NaN 1 6,4068 1,0000 subunit F7AWB4 UDP-N-acetylhexosamine Uap1l1 2 NaN 1 5,2397 1,0000 NaN 1 5,8475 1,0000 pyrophosphorylase-like protein 1

G3XA17 Eukaryotic translation initiation Eif4g2 2 NaN 1 5,5584 1,0000 NaN 1 5,1589 1,0000 factor 4 gamma 2 F8VQ05 Protein Fryl Fryl 2 NaN 1 5,1847 1,0000 NaN 1 5,1855 1,0000 Q9WTI7 Unconventional myosin-Ic Myo1c 2 NaN 1 5,3634 1,0000 NaN 1 5,5976 1,0000 H3BJW3 Cleavage and polyadenylation Cpsf6 2 NaN 1 5,3974 1,0000 NaN 1 5,4166 1,0000 specificity factor subunit 6 H7BWY6 Retinol-binding protein 4 Rbp4 2 NaN 0 NaN 1,0000 NaN 0 5,9058 1,0000 O08710 Thyroglobulin Tg 2 NaN 1 5,6612 1,0000 NaN 1 5,1000 1,0000 O35218 Cleavage and polyadenylation Cpsf2 2 NaN 1 5,1542 1,0000 NaN 1 5,4248 1,0000 specificity factor subunit 2 O35495 Cyclin-dependent kinase 14 Cdk14 2 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 Q3TUQ5 Pinin Pnn 2 NaN 1 4,9474 1,0000 NaN 0 NaN 1,0000 O70194 Eukaryotic translation initiation Eif3d 2 NaN 1 5,3893 1,0000 NaN 1 5,8878 1,0000 factor 3 subunit D O70372 Telomerase reverse transcriptase Tert 2 NaN 1 7,1022 1,0000 NaN 0 NaN 1,0000

P03958 Adenosine deaminase Ada 2 NaN 1 5,8626 1,0000 NaN 1 5,7726 1,0000 P11440 Cyclin-dependent kinase 1 Cdk1 2 NaN 0 NaN 1,0000 NaN 1 5,8218 1,0000 P15105 Glutamine synthetase Glul 2 NaN 1 5,1969 1,0000 NaN 1 5,9290 1,0000 P21447 Multidrug resistance protein 1A Abcb1a 2 NaN 1 5,3267 1,0000 NaN 1 5,3728 1,0000 P27641 X-ray repair cross-complementing Xrcc5 2 NaN 1 5,3124 1,0000 NaN 1 5,5367 1,0000 protein 5 P31938 Dual specificity mitogen-activated Map2k1 2 NaN 0 7,2436 1,0000 NaN 1 6,7055 1,0000 protein kinase kinase 1

P32233 Developmentally-regulated GTP- Drg1 2 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 binding protein 1 P35585 AP-1 complex subunit mu-1 Ap1m1 2 NaN 1 5,8361 1,0000 NaN 1 5,8968 1,0000 P70202 Latexin Lxn 2 NaN 1 5,4063 1,0000 NaN 1 5,4763 1,0000 P70335 Rho-associated protein kinase 1 Rock1 2 NaN 1 5,2634 1,0000 NaN 0 NaN 1,0000 P70404 Isocitrate dehydrogenase [NAD] Idh3g 2 NaN 1 5,9482 1,0000 NaN 1 6,1911 1,0000 subunit gamma 1, mitochondrial P97377 Cyclin-dependent kinase 2 Cdk2 2 NaN 0 NaN 1,0000 NaN 1 5,2693 1,0000 P97814 Proline-serine-threonine Pstpip1 2 NaN 1 5,7509 1,0000 NaN 0 NaN 1,0000 phosphatase-interacting protein 1 Q05D44 Eukaryotic translation initiation Eif5b 2 NaN 1 5,5333 1,0000 NaN 0 NaN 1,0000 factor 5B Q3TU79 DnaJ homolog subfamily B Dnajb1 2 NaN 1 4,8954 1,0000 NaN 1 5,5010 1,0000 member 1 Q3TZZ7 Extended synaptotagmin-2 Esyt2 2 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 Q5M8N4 Epimerase family protein Sdr39u1 2 NaN 0 NaN 1,0000 NaN 1 5,5911 1,0000 SDR39U1 Q5SUF2-2 Luc7-like protein 3 Luc7l3 2 NaN 1 5,0049 1,0000 NaN 1 6,2852 1,0000 Q60I30 Inosine triphosphate Itpa 2 NaN 1 5,2780 1,0000 NaN 0 NaN 1,0000 pyrophosphatase Q61003 T-cell differentiation antigen CD6 Cd6 2 NaN 1 5,5055 1,0000 NaN 1 5,2030 1,0000

Q61425 Hydroxyacyl-coenzyme A Hadh 2 NaN 1 6,7783 1,0000 NaN 1 6,9836 1,0000 dehydrogenase, mitochondrial Q61655 ATP-dependent RNA helicase Ddx19a 2 NaN 1 5,6546 1,0000 NaN 1 6,0665 1,0000 DDX19A Q69ZK0 Phosphatidylinositol 3,4,5- Prex1 2 NaN 1 5,1207 1,0000 NaN 1 5,1936 1,0000 trisphosphate-dependent Rac exchanger 1 protein Q6DFZ1 Golgi-specific brefeldin A- Gbf1 2 NaN 0 NaN 1,0000 NaN 0 NaN 1,0000 resistance factor 1 Q923T9 Calcium/calmodulin-dependent Camk2g 2 NaN 1 5,5677 1,0000 NaN 1 5,9442 1,0000 protein kinase type II subunit gamma Q75N62 GTPase IMAP family member 8 Gimap8 2 NaN 0 NaN 1,0000 NaN 1 5,3667 1,0000 Q8BTI8 Serine/arginine repetitive matrix Srrm2 2 NaN 0 NaN 1,0000 NaN 1 5,4791 1,0000 protein 2 Q8BVE3 V-type proton ATPase subunit H Atp6v1h 2 NaN 1 5,1529 1,0000 NaN 1 5,3170 1,0000 Q8BVG4 Dipeptidyl peptidase 9 Dpp9 2 NaN 1 4,9978 1,0000 NaN 1 6,5506 1,0000 Q8C0D5 Elongation factor Tu GTP-binding Eftud1 2 NaN 1 5,1363 1,0000 NaN 1 5,0335 1,0000 domain-containing protein 1

Q8C196 Carbamoyl-phosphate synthase Cps1 2 NaN 0 5,6515 1,0000 NaN 0 NaN 1,0000 [ammonia], mitochondrial Q8CIH5 1-phosphatidylinositol 4,5- Plcg2 2 NaN 1 5,3415 1,0000 NaN 0 NaN 1,0000 bisphosphate phosphodiesterase gamma-2 Q8CJG0 Protein argonaute-2 Eif2c2 2 NaN 0 NaN 1,0000 NaN 1 4,9957 1,0000 Q8R3C0 Mini-chromosome maintenance Mcmbp 2 NaN 1 5,8303 1,0000 NaN 1 5,6183 1,0000 complex-binding protein Q8R4X3 RNA-binding protein 12 Rbm12 2 NaN 1 5,5149 1,0000 NaN 1 5,4849 1,0000 Q8VDP6 CDP-diacylglycerol--inositol 3- Cdipt 2 NaN 1 5,7962 1,0000 NaN 1 5,2956 1,0000 phosphatidyltransferase Q924C1 Exportin-5 Xpo5 2 NaN 1 5,1821 1,0000 NaN 1 5,3678 1,0000 Q99LE6 ATP-binding cassette sub-family F Abcf2 2 NaN 1 5,1942 1,0000 NaN 1 5,4658 1,0000 member 2 Q9CQI3 Glia maturation factor beta Gmfb 2 NaN 0 NaN 1,0000 NaN 1 5,4609 1,0000 Q9CYA6 Zinc finger CCHC domain- Zcchc8 2 NaN 1 5,4097 1,0000 NaN 0 5,0943 1,0000 containing protein 8 Q9DB05 Alpha-soluble NSF attachment Napa 2 NaN 1 5,3002 1,0000 NaN 1 5,0823 1,0000 protein Q9EQQ9-3 Bifunctional protein NCOAT Mgea5 2 NaN 1 5,2911 1,0000 NaN 0 5,1288 1,0000 Q9JHF5 T-cell, immune regulator 1 Tcirg1 2 NaN 1 4,8328 1,0000 NaN 1 5,2482 1,0000 Q9QUR7 Peptidyl-prolyl cis-trans Pin1 2 NaN 1 5,4003 1,0000 NaN 1 5,4225 1,0000 isomerase NIMA-interacting 1 Q9QXK3 Coatomer subunit gamma-2 Copg2 2 NaN 1 5,0194 1,0000 NaN 0 NaN 1,0000 Q9QZH3 Peptidyl-prolyl cis-trans Ppie 2 NaN 0 NaN 1,0000 NaN 1 5,5869 1,0000 isomerase E Q9WV55 Vesicle-associated membrane Vapa 2 NaN 1 5,1064 1,0000 NaN 0 NaN 1,0000 protein-associated protein A Q9Z277 Tyrosine-protein kinase BAZ1B Baz1b 2 NaN 1 5,4553 1,0000 NaN 1 4,9726 1,0000 Q76MZ3 Serine/threonine-protein Ppp2r1a 15 -0,0009 7 6,7690 1,0000 0,6115 13 7,4669 0,7666 phosphatase 2A 65 kDa regulatory subunit A alpha isoform A2AE04 Eukaryotic translation initiation Eif3i 3 -0,0009 2 6,1802 1,0000 NaN 1 6,2879 1,0000 factor 3 subunit I Supplementary Table 1: proteins identified and quantified in the SILAC experiment, comparing T cells inhibited by TPIN-SCs (CD62Lhi) with those activated by TNE-SCs (CD62Llo) or with the subset activated by TPIN-SCs (CD62Llo). NaN is reported when the quantification criteria are not fulfilled, . A Significance less then 0.05 is indicated by the gray box. Upregulated proteins are are marked in red, downregulated ones are marked in green.