Little Foot’ Fossil Chiselled out of Stone Yields Secrets Mysterious Ancient Hominin Retrieved After 20-Year Effort Might Be a Distinct Species
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NEWS IN FOCUS HEALTH Mysterious polio- PUBLISHING China gets behind INFECTIOUS DISEASE Ebola NEUROSCIENCE Unlocking like disease probed with bold European open-access cases slip under how the brain makes machine learning p.170 plan p.171 the radar p.174 sense of faces p.176 PATRICK LANDMANN/SCIENCE PHOTO LIBRARY LANDMANN/SCIENCE PHOTO PATRICK The unique skeleton was embedded in rock deep inside a South African cave. ARCHAEOLOGY ‘Little Foot’ fossil chiselled out of stone yields secrets Mysterious ancient hominin retrieved after 20-year effort might be a distinct species. BY COLIN BARRAS a musculoskeletal biologist at the University He realized that a handful of small bones in the of Liverpool, UK, who collaborated with the collection belonged to a species of Australo- fter a tortuous 20-year-long excavation, research team that excavated the skeleton. pithecus — ape-like hominins in Africa between an ancient skeleton is starting to reveal The nickname Little Foot, echoing the mythi- about 4 million and 2 million years ago, before new information about early human cal ‘Bigfoot’, refers to the small foot bones that the human genus Homo rose to dominance1. Aevolution. The first of a raft of papers about ‘Lit- were among the first parts of the skeleton to Clarke and his colleagues then found more tle Foot’ suggests that the fossil is a female who be discovered. In 1994, Ronald Clarke, a pal- bones embedded in a matrix of solid rock deep showed some of the earliest signs of human-like, aeoanthropologist at the University of the Wit- in the caves. They began carefully excavating bipedal walking, around 3.67 million years ago. watersrand (Wits University) in Johannesburg, Little Foot, piece by fragile piece, using ham- She might also belong to a distinct species unfa- South Africa, was rifling through boxes of fossils mers and chisels followed by precision tools. miliar to most researchers. “It’s almost a mira- at a field laboratory at the Sterkfontein caves, “The fossilized bone is actually softer than cle it’s come out intact,” says Robin Crompton, about 40 kilometres northwest of Johannesburg. the matrix,” says Crompton. “It’s been an ©2018 Spri nger Nature Li mited. All ri ghts reserve13d. DECEMBER 2018 | VOL 564 | NATURE | 169 NEWS IN FOCUS absolute devil to get it out.” legs are longer than her arms, similar to mod- detailed measurements of the fossil bones. By late last year, Clarke’s team had removed ern humans, making her the oldest hominin “There’s no data — there are almost no meas- enough bones to reconstruct more than 90% for which we can be sure of that feature, says urements of the fossils,” he says. Berger hopes of the skeleton — making it the most complete Crompton. This means that Little Foot was bet- to provide those data in his own publications Australopithecus so far. On 29 November, they ter adapted to walking upright on the ground — although he is still at an early stage of his posted two papers on Little Foot to the bioRxiv than were many other australopiths. analysis of Little Foot. preprint server — one on the age of the speci- Little Foot’s skull, bones and teeth are so unu- Crompton responds that the locomotion men2, the other on the limbs and locomotion3. sual that Clarke and his team have categorized paper is an overview that attempts to recon- On 4–5 December, the team posted third her as the distinct species4 Australopithecus struct how Little Foot moved by drawing on and fourth papers, on the skull and the poten- prometheus, a name first suggested in 1948 the more-solid data in the team’s other papers. tial relationship of the specimen to a known on the basis of a skull fragment found roughly Gabriele Macho, an anthropologist at the Uni- hominin species4, as well as on the arms and an 250 kilometres north of Johannesburg6 and versity of Oxford, UK, agrees that the locomo- injury Little Foot received during her life5. Fur- that remains controversial. They also suggest tion paper is light on solid data, but says the ther papers, on the hand, teeth and inner ear, that A. prometheus is an ancestor of a group team acknowledges the gap. She looks forward are expected in the near future, says Crompton. of hominins called Paranthropus4, which co- to seeing more-detailed papers soon. “The Most will ultimately appear in a special edition existed with early Homo species for about one positive thing is this skeleton is tremendously of the Journal of Human Evolution. million years. important,” she says. “No question about it.” ■ But Lee Berger, an archaeologist also at Wits A NEAR-COMPLETE PUZZLE University, disagrees with the decision to res- 1. Bruxelles, L., Clarke, R. J., Mairee, R., Ortega, R. & Stratford, D. J. Hum. Evol. 70, 36–48 (2014). The bioRxiv papers crystallize ideas that urrect A. prometheus. In a paper scheduled 2. Bruxelles, L. et al. Preprint at bioRxiv https://doi. emerged in earlier publications about the age to be published in the American Journal of org/10.1101/482711 (2018). of the fossil. They also cover new ground, sug- Physical Anthropology, he argues that the name 3. Crompton, R. H. et al. Preprint at bioRxiv https:// doi.org/10.1101/481556 (2018). gesting that Little Foot was an adult female and A. prometheus was never properly defined. If 4. Clarke, R. J. & Kuman, K. Preprint at bioRxiv https:// stood about 130 centimetres tall — just 10 centi- Little Foot constitutes a distinct species, Berger doi.org/10.1101/483495 (2018). metres shorter than the average woman in some thinks, a new name is needed. 5. Heile, A. J., Pickering, T. R., Heaton, J. L. & Clarke, R. J. Preprint at bioRxiv https://doi. modern-human populations. “Little Foot was He is also disappointed by the lack of solid org/10.1101/486076 (2018). quite big,” says Crompton. The paper covering information in the papers on the age and loco- 6. Dart, R. A. Am. J. Phys. Anthropol. 6, 259–284 limbs and locomotion3 reveals that Little Foot’s motion — he would have liked to have seen (1948). GENETICS Machine learning hunts for cause of paralysing illness Scientists hope that probing the immune system will identify the cause of a polio-like disease. BY SARA REARDON machine-learning analysis. The approach “We’ve never really had a smoking gun,” could lead to better diagnostics and provide says Charles Chiu, an infectious-disease nfectious-disease researchers hunting for hints about new treatments. researcher at the University of California, the cause of a mysterious illness that is par- Host-response diagnostic tests haven’t San Francisco, who is leading the machine- alysing children are combining machine been used in the clinic yet. But researchers learning project. He suspects that if EV-D68 Ilearning with a new gene-sequencing tech- are developing similar tests to help pinpoint causes AFM, it damages the spinal cord nique to pin down the culprit. other conditions that can be tricky to diagnose, quickly and then drops to undetectable levels The disease, called acute flaccid myelitis including tuberculosis in the body. (AFM), causes limb weakness and paralysis “We’ve never and bacterial meningitis. Host-response diagnostics are useful when that resembles the symptoms of polio. The US really had This year’s AFM researchers don’t know what they’re looking Centers for Disease Control and Prevention a smoking outbreak started in for, says Purvesh Khatri, a computational sys- (CDC) in Atlanta, Georgia, has confirmed gun.” October, and is the third tems immunologist at Stanford University in 134 cases of AFM in the United States so far in a series of outbreaks California. The composition of the immune this year. Many of those who develop the in the United States that have occurred every system’s defences differs depending on which illness never recover. other year since 2014. Researchers have yet to pathogens are present in the body. So instead Most of the evidence suggests that an enter- find a definitive explanation for the pattern. of looking for the agent itself, Khatri says, ovirus called EV-D68 is causing the illness1, It is also taking scientists an unusually long researchers could look at what the immune but researchers haven’t been able to find the time to determine the cause of the illness, says system is seeing. pathogen in the spinal fluid of children with William Weldon, a microbiologist at the CDC. Most attempts to identify mystery illnesses the disease. Scientists are trying to identify Blood samples taken from many of the involve searching for a pathogen’s DNA the culprit by using a combination of host- people with AFM contain the virus. But many or RNA in areas of the body such as tissue response diagnostics — which look at how the people who never developed AFM symptoms or blood. But the host-response technique immune system responds to pathogens — and also have the virus in their blood. takes a blood sample and sequences all of the 170 | NATURE | VOL 564 | 13 DECEMBER 2018©2018 Spri nger Nature Li mited. All ri ghts reserved. ©2018 Spri nger Nature Li mited. All ri ghts reserved. .