Comparative Study on Surgical Outcome for Benign Vocal Cord Lesions by Conventional Method Versus Coblation
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A Dissertation on COMPARATIVE STUDY ON SURGICAL OUTCOME FOR BENIGN VOCAL CORD LESIONS BY CONVENTIONAL METHOD VERSUS COBLATION Submitted to THE TAMILNADU DR. M.G.R. MEDICAL UNIVERSITY In partial fulfillment, of the requirements for the award of the degree of M.S. BRANCH IV (OTORHINOLARYNGOLOGY) DEPARTMENT OF OTORHINOLARYNGOLOGY GOVERNMENT KILPAUK MEDICAL COLLEGE CHENNAI-10, TAMILNADU MAY 2020 DECLARATION I, Dr. SHAIKH MOHIDEEN A , solemnly declare that the dissertation, titled “COMPARATIVE STUDY ON SURGICAL OUTCOME FOR BENIGN VOCAL CORD LESIONS BY CONVENTIONAL METHOD VERSUS COBLATION” is a bonafide work done by me during the period of May 2018 to April 2019 at Government Kilpauk Medical College and Hospital, Chennai under the expert supervision of PROF. Dr.S.MUTHUCHITRA M.S(ENT)DLO., Professor, Department Of Otorhinolaryngology, Government Kilpauk Medical College and Hospital, Chennai. This dissertation is submitted to The Tamil Nadu Dr. M.G.R. Medical University in partial fulfilment of the rules and regulations for the M.S. degree examinations in Otorhinolaryngology to be held in May 2020. Dr. SHAIKH MOHIDEEN A Date: Place: Chennai-10 BONAFIDE CERTIFICATE This is to certify that the Dissertation titled “COMPARATIVE STUDY ON SURGICAL OUTCOME FOR BENIGN VOCAL CORD LESIONS BY CONVENTIONAL METHOD VERSUS COBLATION” presented by Dr.SHAIKH MOHIDEEN A, postgraduate student(2017 - 2020)in the Department of Otorhinolaryngology, Government Kilpauk Medical College and Hospital, Chennai for partial fulfilment of regulations of the Tamil Nadu Dr. M.G.R. Medical University for the award of degree of M.S. (Otorhinolaryngology) Branch IV, under direct guidance and supervision during the academic period 2017-2020. PROF. Dr.P.VASANTHAMANI PROF. DR. S MUTHUCHITRA, MD DGO MNAMS DCPSY MBA M.S. (ENT). DLO The Dean Professor and Head Kilpauk Medical College, Department of ENT Chennai-10. Govt Kilpauk Medical College, Chennai-10 CERTIFICATE This is to certify that the Dissertation - “COMPARATIVE STUDY ON SURGICAL OUTCOME FOR BENIGN VOCAL CORD LESIONS BY CONVENTIONAL METHOD VERSUS COBLATION” presented by Dr.SHAIKH MOHIDEEN A , is an original work done in the Department of Otorhinolaryngology, Government Kilpauk Medical College and Hospital, Chennai in partial fulfilment of regulations of the Tamil Nadu Dr. M.G.R. Medical University for the award of degree of M.S. (Otorhinolaryngology) Branch IV, under my supervision during the academic period 2017-2020. PROF. DR. S MUTHUCHITRA, M.S. (ENT). DLO PROFESSOR AND HEAD DEPARTMENT OF ENT GOVT KILPAUK MEDICAL COLLEGE, CHENNAI-10 Place : Date : CERTIFICATE – II This is to certify that this dissertation work titled “COMPARATIVE STUDY ON SURGICAL OUTCOME FOR BENIGN VOCAL CORD LESIONS BY CONVENTIONAL METHOD VERSUS COBLATION” of the candidate Dr. SHAIKH MOHIDEEN.A with registration number 221714152 for the award of M.S. Degree in the branch of Otorhinolaryngology. I personally verified the urkund.com website for the purpose of plagiarism check. I found that the uploaded thesis file contains from the introduction to conclusion pages and result shows 8% percentage of plagiarism in the dissertation. PROF. DR. S MUTHUCHITRA, M.S. (ENT). DLO PROFESSOR AND HEAD DEPARTMENT OF ENT GOVT KILPAUK MEDICAL COLLEGE, CHENNAI-10 ACKNOWLEDGEMENT I wish to express my sincere thanks to PROF. Dr. P.VASANTHAMANI MD DGO MNAMS DCPSY MBA, The DEAN, Government Kilpauk Medical College and Hospital for having permitted me to utilize the facilities of the hospital for conducting this study. My heartfelt gratitude to Prof. DR.S MUTHUCHITRA, M.S(ENT)., D.L.O., Professor, Department of Otorhinolaryngology, Government Kilpauk Medical College and Hospital for her constant motivation, valuable suggestions, and expert supervision during the course of this study. I thank Prof. Dr. BHARATHI MOHAN MS (ENT) DLO, Prof. Dr. T. INDRA MS (ENT) for their guidance and support. I wish to thank my Assistant Professors, DR.P.THAMIZHARASAN MS,DLO, DR.K.SANJAYKUMAR.,MS. DR.S.VIGNESH MS., DR.G.UDAYACHANDRIKA MS for their valuable tips and support. I am grateful to all the other post-graduates who most willingly helped me during this study period. I also thank the staff nurses, theatre personnel, OPD staff, Department of Otorhinolaryngology, Government Kilpauk Hospital for their cooperation and assistance in the conduct of this study. I wish to extend my gratitude to my statistician for his expert assistance. Last but not the least, I am indebted and grateful to all the Patients and Normal volunteers who constitute the backbone of this study, who most willingly and selflessly subjected themselves to this study for the sake of the benefit of their community and without whom this study would not have been possible INDEX PAGE S.NO. CONTENTS NO. 1 ABSTRACT 1 2 INTRODUCTION 3 3 REVIEW OF LITERATURE 56 3 AIMS & OBJECTIVE 64 4 MATERIALS AND METHODS 65 5 RESULTS 69 6 DISCUSSION 80 7 CONCLUSION 85 8 BIBLIOGRAPHY 86 9 APPENDIX I PROFORMA 10 APPENDIX II VOICE HANDICAP INDEX 11 APPENDIX III MASTER CHART 12 APPENDIX IV CONSENT 13 APPENDIX V PLAGIARISM 14 APPENDIX VI ETHICAL COMMITTEE APPROVAL ABSTRACT AIM: To compare the efficacy of Conventional microlaryngeal excision with Coablation for benign vocal cord lesion METHODS AND MATERIALS: A sample of 40 patients with a clinical diagnosis of benign vocal cord lesions(polyp,nodule and cyst),were enrolled in our study.Each patient preoperatively underwent videolaryngoscopic examination and the disease severity was assessed with Voice handicap index and GRBAS score,after procuring the consent from them. Conservative treatment was tried and treatment failure patients were randomly divided into two groups viz. Conventional and Coblation method of microlaryngeal surgery. All the operated patients were reassessed at first week,first month and third month with Videolaryngoscopy, VHI and GRBAS score and the reults were analysed. RESULTS: In our study of 40 patients with benign vocal cord lesions, the overall post operative recovery was good in both the group. Surgical ease was better in the coblation group. But both the VHI score and GRBAS score was better in conventional group with significant p value(0.005) CONCLUSION: 1 Coblation being a newer technique can be employed for surgical treatment for microlaryngeal surgery considering its advantages and less time consumption . Yet conventional microlaryngeal surgery with cold steel still gives better result comparatively KEYWORDS: Benign vocal cord lesions, Microlaryngeal surgery, Coblation method, Voice handicap index, GRBAS 2 Introduction INTRODUCTION Embryology Fig 1 Embryology of larynx The larynx is developed from the midline ventral respiratory diverticulum of the foregut known as the laryngotracheal groove. The groove appears posterior to the hypobranchial eminence. This portion of foregut posterior to diverticulum becomes oesophagus. 3 The groove deepens and its edges fuse to form a septum. The laryngotracheal tube formed fuse caudally and extend cranially. The upper end remains separate to communicate with the pharynx. The lower portion elongates and divides, and divides dichotomously to two lobes and forms the bronchi. The portion above the division becomes trachea and uppermost portion becomes the larynx. The epiglottis develops from the posterior part of hypobranchial eminences. The thyroid cartilage develops from the fourth arch cartilage. Other cartilages and trachea are from fifth and sixth arch cartilage. The fourth arch nerve is superior laryngeal nerve and the sixth arch nerve is recurrent laryngeal nerve.1,2 The larynx is an extraordinary versatile organ capable of many rapid and subtle adjustments and capable of sound production over a wide range of pitch and loudness. The structural framework of the larynx is consisting of nine cartilages, their connecting membranes and ligaments. CARTILAGES OF LARYNX (FIG 2,3) Thyroid cartilage This consists of two pentagonal plates that meet anteriorly in the midline at an angle of 90 degree and 120 degree in female and male. It is of funnel shaped in men and cylindrical in female. Thyroid cartilage is covered by outer thick perichondrium and inner thin perichondirum. Attachment of the anterior commisure of vocal cord lacks perichondrium. 4 Cricoid cartilage This is a signet ring shaped cartilage, with a thin anterior arch and a broader posterior lamina about 20 to 30 mm high. The cricothyroid membrane connects the thyroid with cricoid. In the anterior part this membrane is thickened and it is called the cricothyroid ligament. The inferior part is firmly attached to the trachea and superiorly, the lamina has facets for articulation with the arytenoids cartilage. This forms a crucial joint in the production of voice. Epiglottic cartilage It is a leaf like hyaline cartilage whose anterior surface projects above the thyroid cartilage and faces the base of tongue and lingual tonsils. The inferior portion is narrower than the upper part. Thyroepiglottic ligament connects it to thyroid cartilage and hyoepiglotttic ligament connects it to the hyoid superiorly.Along the inferior aspect of the laryngeal surface of the petiole the epiglottic tubercle partially overhangs the anterior commisure. Arytenoid cartilages These are paired pyramidal cartilage which rests upon the cricoid lamina with two processes (vocal and muscular) an apex and a base. The concave base articulates with the cricoid cartilage in a synovial joint. 5 Fig 2 Cartilages, membranes and ligaments of larynx Fig 3 Cartilages, membranes and ligaments of larynx posterior view