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Abstract Book ABSTRACT BOOK 18-27 September 2020 TABLE OF CONTENT ABSTRACT FREE PAPER ABSTRACT FREE PAPER FP-GLA-01 Association of statin use with risk of developing open-angle glaucoma GLA 3 Abstract Title NO 22 Association of statin use with risk of developing open-angle glaucoma First Author IIM 30 Ferdy Iskandar KBR 44 Author Institution Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia OFKOM 58 Co Author Fadima Fitri Larasati (Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) VR 75 Dhiny Lidinillah (Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) POS 89 Gustiandari Fidhya Permanik (Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) REF 100 Florentina Priscilia (Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) ROO 103 Rianti Pratiwi (Research Assistant, Department of Ophthalmology, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) Abstract Type Research ABSTRACT E-POSTER Introduction & Objective Open-angle glaucoma (OAG) is a progressive neurodegenerative disease that leads to glaucomatous optic neuropathy and is the leading cause of irreversible blindness worldwide. Statins are inhibitors of 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a class of cholesterol-lowering medication prescribed for prevention and treatment E-pos GLA 105 of cardiovascular disease. The pleiotropic properties of statins such as antioxidant, immunomodulation, and effects on the nitric oxide synthase system has been proposed to protect retinal ganglion cells (RGC) against glaucomatous damage. E-Pos NO 128 We performed a systematic review to summarize the evidence to address the conflicting results of the association of statin use with OAG. E-Pos IIM 156 Method The systematic review was done by searching the following electronic database from 2010 to 2019: PubMed, MEDLINE, E-Pos KBR 194 and Cochrane Library. Studies in English with human participants were included. Review articles were excluded. Result E-Pos OFKOM 218 We identified four cohort studies and one case control study with a total number of 691.346 participants.No randomized control trials were retrieved. There was inconsistent evidence regarding the protective effect of statins against the E-Pos VR 220 incidence of OAG. One study shows that high dose of statins may increase the risk of OAG (p Conclusion E-Pos POS 243 Statin use with a minimal duration of 2 years was associated with a significant reduction in the risk of developing OAG. Further research is needed to determine the duration and dose used to obtain a protective effect. E-Pos REF 260 Keyword statin, open-angle glaucoma E-Pos ROO 271 Category Free Paper Presentation Latest Update July 21, 2020 Status Submitted Abstract Book Perdami Virtual Scientific Meeting 2020 3 FP-GLA-02 FP-GLA-03 The relationship between caffeine intake and intraocular pressure in Asia The Relationship between Blood Pressure and Primary Open Angle Pacific:a systematic review Glaucoma: a Cross-sectional Study Abstract Title Abstract Title The relationship between caffeine intake and intraocular pressure in Asia Pacific:a systematic review The Relationship between Blood Pressure and Primary Open Angle Glaucoma: a Cross-sectional Study First Author First Author Florentina Priscilia Florentina Priscilia Author Institution Author Institution Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Hospital,Indonesia General Practitioner,Universitas Gadjah Mada Hospital,Indonesia ; Research Assistant, Department of Ophthalmology, Co Author Cipto Mangunkusomo General Hospital,Indonesia Fidhya Permanik (Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Hospital, Indonesia) Co Author Ferdy Iskandar (Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Hospital,Indonesia ) Eva Revana (Ophthalmologist, Universitas Gadjah Mada Hospital,Yogyakarta,Indonesia) Fadima Fitri Larasati (Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Abstract Type Hospital,Indonesia ) Research Rianti Pratiwi (Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Hospital,Indonesia ) Dhiny Lidinillah (Research Assistant,Department of Ophthalmology,Cipto Mangunkusumo General Hospital,Indonesia ) Introduction & Objective Abstract Type Primary open-angle glaucoma (POAG) is a progressive optic neuropathy that leads to blindness. The development of POAG has multifactorial risks; one of them is vascular diseases. Elevated blood pressure (BP) is predicted to have Research associations with the eyes’ vascular impairment while the decrease of BP is predicted to cause a drop in ocular perfusion Introduction & Objective pressure. Both high and low BP lead to an ischemic injury and damage of the optic nerve in some studies, this study aimed Glaucoma is a progressive optic neuropathy that leads to blindness.Asia Pacific accounted for approximately 60% of the to evaluate the relation between blood pressure and POAG. disease and the number will increase to 74% in 2040. The highest prevalence is among Chinese and Japanese. Method Controlling modifiable factors also has its role in maintaining the intraocular pressure (IOP), especially diet, such as The study was conducted as a cross-sectional case-control hospital medical record study with the period from January to reducing caffeine intake which is regularly consumed. The controversial effects of caffeine and IOP are still December 2018. There were 67 cases and 71 controls. The BP compared with those hypertensive-hypotensive patients questionable, thus we conducted a systematic review to summarize the conflicting result of the association. with glaucoma (cases) and hypertensive-hypotensive patients without glaucoma (controls). Method Result This study was conducted from Pubmed,MedLink, and Cochrane between 2002 and 2019. Studies in English and human High diastolic BP (odds ratio: 6.476 with 95% CI 1.976-21.222) and low systolic BP (odds ratio: 5.625 with 95% CI 1.162- subjects were included. Case reports, review articles, and studies with more than one modifiable factor were excluded. 27.222) has a strong positive association with POAG, while high systolic BP (odds ratio: 20.900 with 95% CI 4.306- Result 101.437) and low diastolic BP (odds ratio: 17.795 with 95% CI 4.015-78.866) has a weakly positive association with POAG We included five studies consisted of three interventional and two observational studies with 3389 patients composed in our study. of 3027 normal individuals,118 glaucoma patients, and 244 ocular hypertension patients. Three studies concluded that Conclusion caffeine intake significantly increases IOP.Avisar’s reported patients with glaucoma and ocular hypertension who were Our study concluded that high diastolic and low systolic BP was a strong risk factor for the development of POAG. coffee drinker demonstrated a statistically significant elevation in IOP (p=0.0003), Chadrasekaran’s reported significant However, further experimental studies are needed to investigate the mechanism of vascular disease and optic nerve IOP increase in glaucoma patients with regular coffee drinker (p=0.03), and Tran’s reported a rise in IOP for glaucoma damage. patients in caffeine test (p=0.004). Keyword Conclusion POAG, blood pressure, vascular disease Based on these studies, caffeine intake should be limited for patients with glaucoma or ocular hypertension, since there is a significant elevation in IOP. However, further studies are needed to investigate the long term effect of caffeine in Category IOP and optic nerve damage. Free Paper Presentation Keyword Latest Update caffeine, intraocular pressure August 01, 2020 Category Status Free Paper Presentation Submitted GLAOKOMA 3 Latest Update July 21, 2020 4 Abstract Book Perdami Virtual Scientific Meeting 2020 Abstract Book Perdami Virtual Scientific Meeting 2020 5 FP-GLA-04 FP-GLA-05 NEOVASCULAR GLAUCOMA WITH DIABETIC RETINOPATHY: A CHARACTERISTIC AND SURGICAL OUTCOME OF UVEITIC GLAUCOMA RETROSPECTIVE REVIEW FROM A TERTIARY EYE CARE CENTER IN INDONESIA Abstract Title CHARACTERISTIC AND SURGICAL OUTCOME OF UVEITIC GLAUCOMA First Author Abstract Title Novaqua Yandi NEOVASCULAR GLAUCOMA WITH DIABETIC RETINOPATHY: A RETROSPECTIVE REVIEW FROM A TERTIARY EYE CARE CENTER IN INDONESIA Author Institution Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Hospital First Author Nikho Melga Shalim Co Author Elsa Gustianty (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Author Institution Hospital) Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Hospital Andika Prahasta (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Co Author Hospital) R. Maula Rifada (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye R. Maula Rifada (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Hospital) Hospital) Andika Prahasta (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Sonie Umbara (Ophthalmology Department Faculty of Medicine Padjadjaran University, Cicendo National Eye Hospital) Hospital) Elsa Gustianty (Ophthalmology Department Faculty of Medicine Padjadjaran
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