ESOT2021

POS-008

socioeconomically . . retrospectively and

[email protected] mail: - E

etiologically, etiologically, evaluated were 2020 December

intake.

, Istanbul, Turkey Istanbul, , Fatih

9. 9. - ;224(4):485 2019

Transplantation Unit between January 2013 and and 2013 January between Unit Transplantation

patients’ age, oral dose per , frequency, and dosage of IV calcium IV of dosage and frequency, medicine, per dose oral age, patients’

, 34093, 34093, , Caddesi Vatan , Bulvari Menderes Adnan : ress d Ad

. . Immunobiology . allotransplantation parathyroid successful

Department of General , Parathyroid Parathyroid Surgery, General of Department

list, estimated from variables including the etiology of hypoparathyroidism, hypoparathyroidism, of etiology the including variables from estimated list, for tests DSA and PRA , typing HLA of Importance al. at Yucesan 4

Kaya MD. Kaya Salepçioğlu Harika : Correspondence

Medicine of Faculty University, Vakif Bezmialem , ,

Harika Salepcioglu Kaya Salepcioglu Harika tissue Composite waiting the on patients prioritizing for used be may system scoring a that suggest 53. 53. - ;101(8):3045 2016

CONTACT INFORMATION CONTACT

. . Metab Endocrinol Clin J . Norway in Hypoparathyroidism

patients who have enrolled on the waiting list of the the of list waiting the on enrolled have who patients The transplantation is the most effective curative treatment option. We We option. treatment curative effective most the is transplantation Parathyroid

of Life in in Life of Quality Related - Health and Epidemiology al. at Astor 3

list for transplantation. for list

. terms socioeconomical in , ages productive most their at population young this in

;31(11). ;31(11). 2017

have been registered on the waiting waiting the on registered been have causes autoimmune

the etiology. These data show that hypoparathyroidism is a problem problem health public a is hypoparathyroidism that show data These etiology. the . . Transplant Clin . up - follow year - 1 : immunosuppression term

. 0 202 December

hypoparathyroidism for iatrogenic or idiopathic or or idiopathic or iatrogenic for hypoparathyroidism - short with allotransplantation parathyroid tissue Fresh al. et Yucesan 2

most most Unit, our In patients were between 30 and 49 years old, regardless of of regardless old, years 49 and 30 between were patients the of between December 2013 and and 2013 December between Hospital University f i Vak

To date, 304 of the patients who were diagnosed with with diagnosed were who patients the of 304 date, To 85. 85. - ;28(11):2277 2013 Res. Miner Bone J study. up - follow historic and Transplantation Organ and Nephrology nits of Bezmialem Bezmialem of nits U

, with the necessity of hospitalizations in 12.8% of the patients. patients. the of 12.8% in hospitalizations of necessity the with D, vitamin

postsurgical hypoparathyroidism: a Danish nationwide controlled controlled nationwide Danish a hypoparathyroidism: postsurgical /worked in the , , Endocrinology, Surgery, General the in /worked s work who

particularly young people needing daily supplementations of calcium and and calcium of supplementations daily needing people young particularly METHOD Underbjerg 1 and renal complications to to complications renal and Cardiovascular al. at

and the relevant healthcare professionals professionals healthcare relevant the and ypoparathyroidism h

Permanent hypoparathyroidism has an elevated socioeconomic cost, affecting affecting cost, socioeconomic elevated an has hypoparathyroidism Permanent We would like to thank all our patients diagnosed with with diagnosed patients our all thank to like would We

CONCLUS ONS I ACKNOWLEDGEMENTS REFERENCES

. . retrospectively , medication

and dosage of the the of dosage and features epidemiological their by list

day µg/ . .

parathyroid assess to is aim Our waiting transplantation

. list waiting the

intake calcitrol and, day IU/ in intake , day mg/ in listed intake calcium and presented were in in

distribution of patients on on patients of distribution Etiological : 3 Figure

gender.

Figure 2 Figure values Mean . list waiting the on patients of intake cholecalciferol and , , alcium c Daily :

. . 1) (Figure ) old years 49 and 20 between ( period

I A M

Age distribution of patients on the waiting list by by list waiting the on patients of distribution Age : 1 Figure

congenital idiopatic

Calcitriol Cholecalciferol Calcium reproductive their in are patients female (65%)

>49 <50 <40 <30 <20 autoimmune iatrogenic

>49 <50 <40 <30 <20

, 116 of 178 178 of 116 , Particularly . (15.6%) male are 33 0 0

1

3

4 1

7

9

0,2

female and and female are (84.4%) patients these of 178 old. 500

1232

1421 1

0,4

1835

1917

). 4 , 3 (1, treatment palliative of part as factors important 2009 1000

between 30 and 49 years years 49 and 30 between are (61%) patients 128

2160

2310 2324

0,6

2600

0,72

39

1500 3056 vitamin D which is considered to be one of the most most the of one be to considered is which D vitamin

0,8 ). ). 21790 II class - for and 18594 I class HLA for 0,83

1

2000

defined criteria for the need for daily calcium and active active and calcium daily for need the for criteria defined

1,07

. MFI MFI . max and 2000 MFI min. ( PRA high a ve ha 1,12

61

1,2

2500

68 National and international guidelines and, literature has no no has literature and, guidelines international and National

1,4 six patients patients six , addition In . transplant second their

3000

3 1,58

1,6

. . hypoparathyroidism

for for waiting are (7%) people 14 transplantation,

3500 1,8

of of symptoms the ease to sufficient not is treatment for their first first their for waiting are (93%) people DRUG DOSES REPARTITION BY AGE BY REPARTITION DOSES DRUG

palliative that indicates outcome The (3). antidepressants

197 197 197 them among ; transplantation parathyroid

to use use to enough serious problems social have

Currently, 211 patients are still waiting for for waiting still are patients 211 Currently, 10 8.54 8.44 (mg/dL) Calcium 7.83 8.25

patients patients the of majority that noted also was It job. simpler

1.87 5.89 (pg/mL) PTH 1.63 3.6

18

work in any job and 54% of the patients had to switch to a a to switch to had patients the of 54% and job any in work

ETIOLOGY

118 months. months. 118 found was list transplantation Iatrogenic Value Mean ongenital C Autoimmune

Field studies showed 25% of the patients were unable to to unable were patients the of 25% showed studies Field

of hypoparathyroidism before enrolling on the the on enrolling before hypoparathyroidism of of of etiology by levels calcium and PTH : 1 Table . hypoparathyroidism

shows a significant decrease (2). (2). decrease significant a shows

waiting time of 48 months. The average duration duration average The months. 48 of time waiting

calcitriol , and cholecalciferol , calcium (Figure 2). 2). (Figure determined were distribution age the on depending intake

and active vitamin D preparations, but their quality of life life of quality their but preparations, D vitamin active and

since, with an average average an with since, transplanted were

Presented them

8.44mg/dL, 8.54mg/dL, 8.25mg/dL and 7.83mg/dL, respectively in each etiological group etiological each in respectively 7.83mg/dL, and 8.25mg/dL 8.54mg/dL, 8.44mg/dL, . The mean daily daily mean The . 1) Table (

male female

hypoparathyroidism (1). These patients use daily calcium calcium daily use patients These (1). hypoparathyroidism

transplantation were found eligible and 93 of of 93 and eligible found were transplantation GENDER

3.6pg/mL and 1.63pg/mL, in each etiological group, group, etiological each in 1.63pg/mL, and 3.6pg/mL mean calcium levels were were levels calcium mean The . 3) Figure ( respectively

cramping are seen in patients with permanent permanent with patients in seen are cramping

AGE REPARTITION BY BY REPARTITION AGE

304 patients who enrolled for parathyroid parathyroid for enrolled who patients 304 The The . patients of 2% in congenital and , 1.87pg/mL, 1.87pg/mL, , 5.89pg/mL were

at: levels (PTH) hormone parathyroid intact mean

Symptoms such as and and fatigue as such Symptoms life. of quality in decrease

was iatrogenic in 94% of the patients, autoimmune in 3%, idiopathic in 1%, 1%, in idiopathic 3%, in autoimmune patients, the of 94% in iatrogenic was hypoparathyroidism of etiology The

significant a causes hypoparathyroidism Permanent

RESULTS

INTRODUCTION

Nephrology of Division , Medicine Internal of Department

, , Medicine of Faculty , University Vakıf Bezmialem , Unit Transplantation , , Medicine of Faculty , University Vakıf Bezmialem , Biology Medical of Department

3 4

of General General of Department , Medicine of Faculty , University Vakıf Bezmialem Parathyroid Center, Research Experimental , University Vakıf Bezmialem , Surgery

1 2

, O. F. Duzenli F. O. , Karatoprak U. , Goncu B. , Kaya Salepcioglu H. , A. Akcakaya A. , Kazancioglu R. , Ersoy E. Y. , Yucesan E. ,

2 2 1 1 4 1 3 2

as a a as while patients hypoparathyroidism transplantation parathyroid of candidate

features epidemiological of Evaluation permanent for medication the of dosage and