Canine IL-2 R beta Protein, His Tag Catalog # ILA-C52H5

Synonym Formulation

IL2RB,RP5-1170K4.6,CD122,P70-75 Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is Source added as protectant before lyophilization.

Canine IL-2 R beta, His Tag (ILA-C52H5) is expressed from human 293 cells Contact us for customized product form or formulation. (HEK293). It contains AA Asn 30 - Pro 246 (Accession # F1PGA6-1). Reconstitution Molecular Characterization Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA. This protein carries a polyhistidine tag at the C-terminus. Storage The protein has a calculated MW of 27.0 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. For long term storage, the product should be stored at lyophilized state at -20°C or lower. Endotoxin Please avoid repeated freeze-thaw cycles. Less than 1.0 EU per μg by the LAL method. This product is stable after storage at: Purity -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. >95% as determined by reduced SDS-PAGE.

SDS-PAGE

Canine IL-2 R beta, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Background

Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind 2. The low affinity form is a monomer of the alpha subunit and is not involved in . The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from . Clinical and Translational Updates

www.acrobiosystems.com 8/13/2021 Canine IL-2 R beta Protein, His Tag Catalog # ILA-C52H5

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www.acrobiosystems.com 8/13/2021