Drug Users Sweat It out by National Institute of Justice Staff

Total Page:16

File Type:pdf, Size:1020Kb

Drug Users Sweat It out by National Institute of Justice Staff Technology Update Drug Users Sweat It Out By National Institute of Justice Staff Authors’ Note: The views and opinions in this article are those of the authors and do not reflect an official position of the U.S. government. References to any specific commercial products by trade name, trademark, manufacturer or otherwise do not consti­ tute or imply its endorsement, recommendation or favoring by the U.S. government. ith a number of high- laboration with the Pretrial Services drug use not detected by urinalysis. profile cases of alleged Agency in Washington, D.C. Sweat patches can detect several substance abuse in pro­ drugs, including amphetamine and Wfessional sports, the Current Collection methamphetamine, heroin, mor­ topic of drug testing has received a phine, methadone, marijuana and great deal of mainstream media Methods phencyclidine. However, the concen­ attention in recent months. Behind trations of the drugs in the collected Urinalysis is the most common the newspaper stories are ongoing specimen are lower than those col­ method of drug testing used in crimi­ research efforts to find better meth­ lected through urinalysis. Also, a sin­ nal justice settings, even though it ods to detect drug use. gle test uses an entire patch, which can be intrusive and uncomfortable Drug testing is used at all points in precludes repeat testing and testing for both the subject and the collec­ the criminal justice system. Results for multiple drugs. tor, requires burdensome chain-of- are used to help make decisions The Macroduct differs from the custody procedures and may require about pretrial release, probation and sweat patch in that it stimulates pro­ special facilities. parole. To improve the practice of duction of sweat, takes minutes Hair analysis is regarded as per­ drug testing in the criminal justice rather than days and collects liquid haps the most advanced technique, system, the National Institute of Jus­ versus dried sweat. The Macroduct but it may carry potential problems tice — the research, development — originally designed to test infants such as contamination and hair color and evaluation agency of the U.S. for cystic fibrosis — stimulates per­ bias (i.e., the darker a person’s hair, Department of Justice — funds spiration through a lightweight the more it accumulates traces of research exploring new methods and power source that delivers an organ­ ingested drugs). Saliva detection also evaluates the potential of alternative ic compound (pilocarpine) through shows promise as an alternative col­ techniques. NIJ’s latest project discs placed on a person’s skin. Per­ lection method, but results can be assessed the feasibility of adapting a spiration is then forced from the skewed if the subject smokes or device called the Macroduct1 to col­ sweat glands into the Macroduct’s takes drugs orally just before being lect sweat and test for drug use in collector, a plastic device with spi­ tested. criminal justice settings. raled tubing. The tubing is then The project, a collaborative effort removed and the sample is trans­ between the Institute for Social Detecting Drugs ferred via a blunt-needle syringe into Analysis, the University of Utah’s a storage vial and analyzed. Center for Human Toxicology, and In Sweat the National Institute of Standards Correctional agencies are already and Technology’s Office of Law experimenting with sweat patches as The Evaluation Enforcement Standards, compared a way to test for drug use. A sweat After a pilot study had showed the accuracy of test results collected patch sticks to a person’s skin and that sweat samples could be collect­ using different devices and methods absorbs perspiration over days or ed in a criminal justice setting using — sweat patches, the Macroduct and weeks, which results in a sample of the Macroduct, a field study was urinalysis. The project also collected dried sweat. The adhesive used with completed using arrested individuals data about participants’ perceptions the sweat patch bonds tightly with at the Pretrial Services Agency. of the different collection methods. the skin to prevent tampering. Stud­ From the pilot study, researchers The research was conducted in col­ ies show that patches can detect learned that it would take about 30 Testing using sweat samples identified two to three times the number of cocaine users and nearly two times the number of opiate users compared to urinalysis. minutes to collect enough sweat (60 cost and a lower volume of sweat col­ detection of opiates and cocaine, it micro liters) using the Macroduct lected compared to the sweat patch. was consistent with urine, and out­ system. For the field test, researchers The Macroduct costs $7 per collec­ performed the sweat patch for the minimized collection time and maxi­ tion with an initial investment of detection of PCP. mized the amount of sweat collected more than $1,500 for the power The Bottom Line. Based on all of by increasing the concentration of source. In comparison, the sweat the findings, the researchers recom­ pilocarpine (the substance that stim­ patch costs $5 per collection and mend further study of the collection ulates perspiration), increasing the requires no power source. and analysis of sweat to fully under­ voltage that induces the pilocarpine, The volume of liquid sweat col­ stand its advantages and limitations. using more than one collection lected by an unmodified Macroduct However, the potential is there for device and using a collection device system is a limitation. The amount sweat to be used as an alternative modified for this purpose by the collected is only enough to perform a sample to urine in drug testing. In manufacturer (under a subcontract). limited screen for drugs of abuse and addition, the immediate, observable a confirmation of no more than one collection of liquid sweat versus the or two drugs. However, the Macrod­ longer term collection of dried sweat The Results uct system modified for this study in a patch, could work well in correc­ How well did sweat collected harvested larger samples at a faster tional facilities. using the Macroduct method detect rate. The full NIJ report, An Evaluation drugs compared with urinalysis? In detecting drugs, sweat detec­ of Innovative Sweat-Based Drug Test­ Impressively well. Testing using tion was outperformed by hair and ing Techniques for Use in Criminal Jus­ sweat samples identified two to three saliva analysis for the detection of tice Drug Testing, NIJ Report 606-03, times the number of cocaine users cannabinoids. can be found online at http:// and nearly two times the number of Finally, whatever the collection nij.ncjrs. org/publications/pubs_ opiate users compared to urinalysis. method, testing may be limited by db.asp. The report was prepared for As to the volunteers’ rating of the what little is known about how drugs the National Institute of Justice, U.S. level of unpleasantness, embarrass­ are deposited into sweat; hence it Department of Justice, by the Office ment and perception of the length of can sometimes be difficult to inter­ of Law Enforcement Standards of the time required to collect the speci­ pret test results. National Institute of Standards and men, analysis of the self-reports The Good. The researchers con­ Technology under Interagency Agree­ revealed that volunteers found uri­ cluded that sweat could indeed be ment 94-IJ-R-094. nalysis to be the most embarrassing harvested using the Macroduct collection procedure, but that in method in criminal justice settings. ENDNOTES other respects, collecting sweat and The collection method was consid­ 1 The Macroduct® Sweat Collection Sys­ urine did not differ demonstrably. ered noninvasive, easily observed tem is manufactured by Wescor Inc. and well-tolerated by subjects. For many drugs, sweat may be a prefer­ What It All Means able specimen to urine for the detec­ The Bad. The barriers to using the tion of drug use. It appeared to be a Macroduct method include a higher good to excellent sample for the Reprinted from the June 2004 issue of Corrections Today, Vol. 66, No. 3 with permission from: The American Correctional Association, 4380 Forbes Blvd., Lanham, Maryland 20706 .
Recommended publications
  • Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized with Wavelengths and Contact Cooling: a Preliminary Report
    Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized With Wavelengths and Contact Cooling: A Preliminary Report Yohei Tanaka, MD, Kiyoshi Matsuo, MD, PhD, and Shunsuke Yuzuriha, MD, PhD Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan Correspondence: [email protected] Published May 28, 2010 Objective: Infrared (IR) irradiation specialized with wavelengths and contact cooling increases the amount of water in the dermis to protect the subcutaneous tissues against IR damage; thus, it is applied to smooth forehead wrinkles. However, this treatment consistently induces brow ptosis. Therefore, we investigated whether IR irradiation induces muscle thinning. Methods: Rat central back tissues were irradiated with the specialized IR device. Histological evaluation was performed on sagittal slices that included skin, panniculus carnosus, and deep muscles. Results: Significant reductions in panniculus carnosus thickness were observed between controls and irradiated tissues at postirradiation day 30 (P30), P60, P90, and P180; however, no reduction was observed in nonirradiated controls from days 0 to 180. No significant changes were observed in the trunk muscle over time. From day 0, dermal thickness was significantly reduced at P90 and P180; however, no difference was observed between P180 and nonirradiated controls at day 180. DNA degradation consistent with apoptosis was detected in the panniculus carnosus at P7 and P30. Conclusions: We found that IR irradiation induced long-lasting superficial muscle thinning, probably by a kind of apoptosis. The panniculus carnosus is equivalent to the superficial facial muscles of humans; thus, the changes observed here reflected those in the frontalis muscle that resulted in brow ptosis.
    [Show full text]
  • Table S1. Checklist for Documentation of Google Trends Research
    Table S1. Checklist for Documentation of Google Trends research. Modified from Nuti et al. Section/Topic Checklist item Search Variables Access Date 11 February 2021 Time Period From January 2004 to 31 December 2019. Query Category All query categories were used Region Worldwide Countries with Low Search Excluded Volume Search Input Non-adjusted „Abrasion”, „Blister”, „Cafe au lait spots”, „Cellulite”, „Comedo”, „Dandruff”, „Eczema”, „Erythema”, „Eschar”, „Freckle”, „Hair loss”, „Hair loss pattern”, „Hiperpigmentation”, „Hives”, „Itch”, „Liver spots”, „Melanocytic nevus”, „Melasma”, „Nevus”, „Nodule”, „Papilloma”, „Papule”, „Perspiration”, „Petechia”, „Pustule”, „Scar”, „Skin fissure”, „Skin rash”, „Skin tag”, „Skin ulcer”, „Stretch marks”, „Telangiectasia”, „Vesicle”, „Wart”, „Xeroderma” Adjusted Topics: "Scar" + „Abrasion” / „Blister” / „Cafe au lait spots” / „Cellulite” / „Comedo” / „Dandruff” / „Eczema” / „Erythema” / „Eschar” / „Freckle” / „Hair loss” / „Hair loss pattern” / „Hiperpigmentation” / „Hives” / „Itch” / „Liver spots” / „Melanocytic nevus” / „Melasma” / „Nevus” / „Nodule” / „Papilloma” / „Papule” / „Perspiration” / „Petechia” / „Pustule” / „Skin fissure” / „Skin rash” / „Skin tag” / „Skin ulcer” / „Stretch marks” / „Telangiectasia” / „Vesicle” / „Wart” / „Xeroderma” Rationale for Search Strategy For Search Input The searched topics are related to dermatologic complaints. Because Google Trends enables to compare only five inputs at once we compared relative search volume of all topics with topic „Scar” (adjusted data). Therefore,
    [Show full text]
  • There Are 25 Questions, Each Worth 3 Points and a Short Essay Worth 25 Points. DO YOUR OWN WORK !! Use Your Time Wisely 1. T
    Mr. Holder Integumentary System – Unit 5 December 3, 2015 ARC TEST 1.0 DO NOT MARK OR WRITE ON THIS QUIZ !! There are 25 questions, each worth 3 points and a short essay worth 25 points. DO YOUR OWN WORK !! Use Your Time Wisely 1. The Integumentary System is divided into how many layers? a) 2 b) 3 c) 4 d) 6 2. What are the two major groups of membranes covering the human body? a) Epithelial & Mucus b) Cutaneous & Mucus c) Epithelial & Connective Tissue d) None of these 3. Which internal membrane provides protection for your joints? a) Serous b) Synovial c) Cutaneous d) Mucus 4. These membranes line internal cavities exposed to air & excrete a gooey substance. a) Serous b) Synovial c) Cutaneous d) Mucus 5. The Integumentary System protects the human body from … a) Friction b) Hot & Cold Temperature c) Bacteria d) All of These 6. Which stratum of the epidermis is full of keratin, cornified to prevent water loss? a) Basale b) Granulosum c) Corneum d) None of These 7. Which body system extends into the dermis to provide information to your brain? a) Cardiovascular b) Immune c) Integumentary d) Nervous 8. Subcutaneous tissue includes adipose tissue or fat. It is also known as the … a) Dermis b) Papillary Layer c) Hypodermis d) Reticular Layer 9. The dermis is divided into two layers. Which of these is the thickest? a) Papillary b) Reticular c) Basale d) Hypodermis 10. Which stratum of the epidermis is responsible for new cell production? a) Corneum b) Basale c) Granulosum d) Spinosum Page 1 Mr.
    [Show full text]
  • Infection of Human Sweat Glands by SARS-Cov-2 Jia Liu1,Yufengli1,Liangliu2,Xudonghu3,Xiwang1, Hengrui Hu1, Zhihong Hu 1,Yiwuzhou2 and Manli Wang 1
    Liu et al. Cell Discovery (2020) 6:84 Cell Discovery https://doi.org/10.1038/s41421-020-00229-y www.nature.com/celldisc CORRESPONDENCE Open Access Infection of human sweat glands by SARS-CoV-2 Jia Liu1,YufengLi1,LiangLiu2,XudongHu3,XiWang1, Hengrui Hu1, Zhihong Hu 1,YiwuZhou2 and Manli Wang 1 Dear Editor, detected in the epidermis or sebaceous glands (Supple- Severe acute respiratory syndrome coronavirus 2 mentary Fig. S1b). (SARS-CoV-2) induces multiorgan dysfunction by ram- Sweat glands comprise the inner secretory luminal and paging throughout the body1,2. As dermatological lesions outer myoepithelial cell layers, while sweat ducts com- affect 1%–20% of patients with coronavirus disease 2019 prise epithelial and basal cells6. To explore the details of (COVID-19)3, the skin may not be exempt. Skin biopsy SARS-CoV-2 cell tropism, colocalization analysis of viral samples reportedly have low SARS-CoV-2 loads4,5; how- spike proteins and individual cell markers was performed. + ever, it remains unclear whether SARS-CoV-2 directly In sweat glands, the keratin (Krt) 7 secretory luminal causes cutaneous manifestations, and if so, what is the cell cells were found to be major target cells for SARS-CoV-2 + tropism of the virus in the skin and whether skin contact infection, whereas the Krt5 cells/alpha smooth muscle + poses a risk of viral transmission. actin (α-SAM) myoepithelial cells were not infected To explore these issues, we obtained skin autopsy (Supplementary Fig. S2a, the middle panel). In sweat − − + samples from five patients with COVID-19. Although they ducts, some Krt5 /Krt7 epithelial cells, but not Krt5 had no clinical dermatological manifestations (Supple- basal cells, were infected (Supplementary Fig.
    [Show full text]
  • Adolescent Hygiene Basics
    Adolescent Hygiene Basics Puberty causes all kinds of changes in your body. Your skin and scalp may suddenly get oily very easily. Every day it seems you have new hair growing in different places. At times, you seem to sweat for no reason — and you may notice there are odors where you never had them before. What should you do about it? These bodily changes are a normal part of becoming an adult. Still, some of them can be a real source of anxiety. Who wants to worry about whether their underarms smell, anyway? Read below for information on some hygiene basics — and learn how to deal with greasy hair, perspiration, and body hair. Oily Hair The hormones that create acne are the same ones that can make you feel like you're suddenly styling your hair with a comb dipped in motor oil. Each strand of hair has its own sebaceous (oil) gland, which keeps the hair shiny and waterproof. But during puberty, when the sebaceous glands produce extra oil, it can make your hair look too shiny, oily, and greasy. Washing your hair every day or every other day can help control oily hair. Dozens of shampoos are available in drugstores and supermarkets for you to choose from — most brands are pretty similar, although you might want to try one that is specially formulated for oily hair. Use warm water and a small amount of shampoo to work up a lather. Don't scrub or rub too hard — this doesn't get rid of oil any better and can irritate your scalp or damage your hair.
    [Show full text]
  • Or Moisture-Associated Skin Damage, Due to Perspiration: Expert Consensus on Best Practice
    A Practical Approach to the Prevention and Management of Intertrigo, or Moisture-associated Skin Damage, due to Perspiration: Expert Consensus on Best Practice Consensus panel R. Gary Sibbald MD Professor, Medicine and Public Health University of Toronto Toronto, ON Judith Kelley RN, BSN, CWON Henry Ford Hospital – Main Campus Detroit, MI Karen Lou Kennedy-Evans RN, FNP, APRN-BC KL Kennedy LLC Tucson, AZ Chantal Labrecque RN, BSN, MSN CliniConseil Inc. Montreal, QC Nicola Waters RN, MSc, PhD(c) Assistant Professor, Nursing Mount Royal University A supplement of Calgary, AB The development of this consensus document has been supported by Coloplast. Editorial support was provided by Joanna Gorski of Prescriptum Health Care Communications Inc. This supplement is published by Wound Care Canada and is available at www.woundcarecanada.ca. All rights reserved. Contents may not be reproduced without written permission of the Canadian Association of Wound Care. © 2013. 2 Wound Care Canada – Supplement Volume 11, Number 2 · Fall 2013 Contents Introduction ................................................................... 4 Complications of Intertrigo ......................................11 Moisture-associated skin damage Secondary skin infection ...................................11 and intertrigo ................................................................. 4 Organisms in intertrigo ..............................11 Consensus Statements ................................................ 5 Specific types of infection .................................11
    [Show full text]
  • The Integumentary System the Integumentary System
    Essentials of Anatomy & Physiology, 4th Edition Martini / Bartholomew The Integumentary System PowerPoint® Lecture Outlines prepared by Alan Magid, Duke University Slides 1 to 51 Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integumentary Structure/Function Integumentary System Components • Cutaneous membrane • Epidermis • Dermis • Accessory structures • Subcutaneous layer (hypodermis) Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integumentary Structure/Function Main Functions of the Integument • Protection • Temperature maintenance • Synthesis and storage of nutrients • Sensory reception • Excretion and secretion Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integumentary Structure/Function Components of the Integumentary System Figure 5-1 Integumentary Structure/Function The Epidermis • Stratified squamous epithelium • Several distinct cell layers • Thick skin—five layers • On palms and soles • Thin skin—four layers • On rest of body Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integumentary Structure/Function Cell Layers of The Epidermis • Stratum germinativum • Stratum spinosum • Stratum granulosum • Stratum lucidum (in thick skin) • Stratum corneum • Dying superficial layer • Keratin accumulation Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings Integumentary Structure/Function The Structure of the Epidermis Figure 5-2 Integumentary Structure/Function Cell Layers of The Epidermis • Stratum germinativum
    [Show full text]
  • Components of the Integumentary System Include 1
    Components of the Integumentary System include 1. cutaneous membrane (skin) a. epidermis (superficial epithelium) b. dermis (under lying connective tissue layer) 2. hair 3. nails } 2,3,4 accessory structures 4. exocrine glands • account for 16% of body weight •1½ -2m2 in surface area General Functions of Skin •Protection: of underlying tissues & organs •Excretion: of salts, H2O, organic wastes •Maintenance: of normal body temp. •SthiSynthesis: of a s tero id, v itam in D3-whic h is conver te d to a hormone (calcitrol), important to normal calcium metabolism •Storage: of nutrients •Detection: of various sensations (touch, pressure, pain, temp.) Thick Skin The Epidermis •Palm of hands, sole of foot •Provides mechanical protection •5 layers of keratinocytes •Helps keep micoorganisms out of the body •Epidermis ≈ 0.48mm thick •Consists of stratified squamous epithelium Thin Skin •Everywhere else •Most abundant epithelial cells are called keratinocytes •4 layers of keratinocytes •Epidermis ≈ 0.08mm thick 1 Stratum Germinativum •Innermost layer •Form epidermal ridges to increase contact area to the dermis (better holding power) •The surface of the skin forms patterns that follow the epidermal ridges, these skin surface ridges a. increase friction b. assure a good grip c. are unique to you d. do not change in your lifetime Stratum Spinosum •The dominant cells here are basal cells, these are •Means “spiny layer” stem cells which divide to replace the sloughed off dead skin cells above •8-10 cells thick •Keratinocytes connected by desmosomes •Merkel cells are sensitive to touch and when disturbed release chemicals that stimulate nerve •Contain Langerhan cells (part of immune response) endings They fight a.
    [Show full text]
  • Guideline: Assessment, Prevention and Treatment of Moisture Associated Skin Damage (MASD) in Adults & Children
    British Columbia Provincial Nursing Skin & Wound Committee Guideline: Assessment, Prevention and Treatment of Moisture-Associated Skin Damage (MASD) in Adults & Children Developed by the British Columbia Provincial Nursing Skin & Wound Committee in collaboration with Wound Clinicians from: / Title Guideline: Assessment, Prevention and Treatment of Moisture Associated Skin Damage (MASD) in Adults & Children Practice Nurses in accordance with health authority/agency policy. Level Clients with moisture-associated skin damage require an interprofessional approach to provide comprehensive, evidence-based assessment, prevention and treatment. This clinical guideline focuses solely on the role of the nurse, as one member of the interprofessional team providing client care. Background Moisture-Associated Skin Damage (MASD) is a general term for skin damage that occurs when the skin is exposed to moisture such as perspiration, urine or feces or both, wound exudate, saliva, mucous fistula, and/or stomal effluent for a prolonged period of time. MASD is differentiated from Stage 1 and Stage 2 Pressure Injuries (PI) by assessing the location of tissue damage (e.g., perianal skin damage versus a PI over a bony prominence), the wound bed characteristics (edge, colour, odour, and slough) (see Appendix A). MASD can present as mild, moderate, or severe and can occur in all client age groups: mild MASD presents as irritation and inflammation of the skin, and moderate to severe MASD presents with blistering and erosion and/or denudation of the epidermal
    [Show full text]
  • Atlas of DISEASES of the NAIL
    An Atlas of DISEASES OF THE NAIL THE ENCYCLOPEDIA OF VISUAL MEDICINE SERIES An Atlas of DISEASES OF THE NAIL Phoebe Rich, MD Oregon Health Sciences University Portland, Oregon, USA Richard K.Scher, MD College of Physicians and Surgeons Columbia University, New York, USA The Parthenon Publishing Group International Publishers in Medicine, Science & Technology A CRC PRESS COMPANY BOCA RATON LONDON NEW YORK WASHINGTON, D.C. Published in the USA by The Parthenon Publishing Group Inc. 345 Park Avenue South, 10th Floor New York NY 10010 USA This edition published in the Taylor & Francis e-Library, 2005. To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk. Published in the UK and Europe by The Parthenon Publishing Group 23–25 Blades Court Deodar Road London SW15 2NU UK Copyright © 2003 The Parthenon Publishing Group Library of Congress Cataloging-in-Publication Data Rich, Phoebe An atlas of diseases of the nail/Phoebe Rich, R.K.Scher p.; cm.—(The encyclopedia of visual medicine series) Includes bibliographical references and index. ISBN 1-85070-595-X 1. Nails (Anatomy)—Diseases—Atlases. I. Title: Diseases of the nail. II. Rich, Phoebe III. Title. IV. Series. [DNLM: 1. Nail Diseases—diagnosis—Atlases. 2. Nail Diseases—therapy—Atlases. WR 17 S326a 2002] RL165.S35 2002 616.5′47—dc21 2002025346 British Library Cataloguing in Publication Data Rich, Phoebe— An atlas of diseases of the nail 1. Nails (Anatomy)—Diseases I. Title II. Scher, Richard K., 1929– 616.5′47 ISBN 0-203-49069-X Master e-book ISBN ISBN 0-203-59671-4 (Adobe eReader Format) ISBN 1-85070-595-X (Print Edition) First published in 2003 This edition published in the Taylor & Francis e-Library, 2005.
    [Show full text]
  • Physiology of Sweat Gland Function: the Roles of Sweating and Sweat Composition in Human Health Lindsay B
    COMPREHENSIVE REVIEW Physiology of sweat gland function: The roles of sweating and sweat composition in human health Lindsay B. Baker Gatorade Sports Science Institute, PepsiCo R&D Physiology and Life Sciences, Barrington, IL, USA ABSTRACT ARTICLE HISTORY The purpose of this comprehensive review is to: 1) review the physiology of sweat gland function Received 30 April 2019 and mechanisms determining the amount and composition of sweat excreted onto the skin Revised 6 June 2019 surface; 2) provide an overview of the well-established thermoregulatory functions and adaptive Accepted 8 June 2019 responses of the sweat gland; and 3) discuss the state of evidence for potential non-thermo- KEYWORDS regulatory roles of sweat in the maintenance and/or perturbation of human health. The role of Chloride; potassium; sauna; sweating to eliminate waste products and toxicants seems to be minor compared with other sodium; sweat biomarkers; avenues of excretion via the kidneys and gastrointestinal tract; as eccrine glands do not adapt to thermoregulation increase excretion rates either via concentrating sweat or increasing overall sweating rate. Studies suggesting a larger role of sweat glands in clearing waste products or toxicants from the body may be an artifact of methodological issues rather than evidence for selective transport. Furthermore, unlike the renal system, it seems that sweat glands do not conserve water loss or concentrate sweat fluid through vasopressin-mediated water reabsorption. Individuals with high NaCl concentrations in sweat (e.g. cystic fibrosis) have an increased risk of NaCl imbalances during prolonged periods of heavy sweating; however, sweat-induced deficiencies appear to be of minimal risk for trace minerals and vitamins.
    [Show full text]
  • Guidelines for Testing Drugs Under International Control in Hair, Sweat and Oral Fluid
    Guidelines for Testing Drugs under International Control in Hair, Sweat and Oral Fluid MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Guidelines for Testing Drugs under International Control in Hair, Sweat and Oral Fluid MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS New York, 2014 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases, but any modification has to be validated before it is integrated into laboratory routines. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. ST/NAR/30/Rev.3 Original language: English © United Nations, May 2014. All rights reserved, worldwide The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorsement of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements UNODC’s Laboratory and Scientific Section (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Professor Franco Tagliaro, Uni- versity of Verona, Professor Donata Favretto, University of Padova and Mr.
    [Show full text]