Mouse TRP1 / TYRP1 Protein (His Tag)

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Mouse TRP1 / TYRP1 Protein (His Tag) Catalog Number: 51289-M08B General Information SDS-PAGE: Gene Name Synonym: b; brown; isa; Oca3; TRP-1; TRP1; Tyrp Protein Construction: A DNA sequence encoding the mouse Tyrp1 (Met1-Thr474) was expressed with a polyhistidine tag at the C-terminus. Source: Mouse Expression Host: Baculovirus-Insect Cells QC Testing Purity: > 95 % as determined by SDS-PAGE. Endotoxin: Protein Description < 1.0 EU per μg protein as determined by the LAL method. Tyrosinase-related protein 1, also known as TYRP1 or TRP1, is a Stability: melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Mutations in this Samples are stable for up to twelve months from date of receipt at -70 ℃ enzyme are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. TYRP1 / TRP1 is involved in the Predicted N terminal: Gln 25 oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- Molecular Mass: quinone-2-carboxylic acid. This enzyme may regulate or influence the type of melanin synthesized. The expression of Tyrosinase-related protein 1 The recombinant mouse Tyrp1 consists 461 amino acids and predicts a (TYRP1) is regulated by the microphthalmia-associated transcription factor molecular mass of 52.4 kDa. (MITF). There is mounting evidence demonstrating that in addition to its role in eumelanin synthesis, TYRP1 is involved in maintaining stability of Formulation: tyrosinase proliferation and melanocyte cell death. Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0. References Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. Usage Guide Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: Detailed reconstitution instructions are sent along with the products. Manufactured By Sino Biological Inc., FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. Fax :+86-10-5862-8288 Tel:+86-400-890-9989 http://www.sinobiological.com.

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Gene Section Short Communication
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL INIST-CNRS Gene Section Short Communication TYRP1 (tyrosinase-related protein 1) Kunal Ray, Mainak Sengupta, Sampurna Ghosh Academy of Scientific and Innovative Research (AcSIR), Campus at CSIR - Central Road Research Institute, Mathura Road, New Delhi - 110 025, [email protected] (KR); University of Calcutta, Department of Genetics, 35, Ballygunge Circular Road, Kolkata - 700 019, [email protected]); [email protected] (MS, SG) India. Published in Atlas Database: April 2016 Online updated version : http://AtlasGeneticsOncology.org/Genes/TYRP1ID46370ch9p23.html Printable original version : http://documents.irevues.inist.fr/bitstream/handle/2042/68125/04-2016-TYRP1ID46370ch9p23.pdf DOI: 10.4267/2042/68125 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2016 Atlas of Genetics and Cytogenetics in Oncology and Haematology Abstract Location: 9p23 TYRP1 gene, having a chromosomal location of 9p23, encodes a melanosomal enzyme belonging to DNA/RNA the tyrosinase family. TYRP1 catalyses oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) Description into indole-5,6-quinone-2-carboxylic acid. TYRP1 In Chromosome 9, the 24,852 bases long gene starts is also thought to play a role in stabilizing tyrosinase from12,685,439 bp from pter and ends at 12,710,290 and modulates its catalytic activity, in maintenance bp from pter; Orientation: Plus strand. The gene of melanosome structure, affecting melanocyte contains 8 exons and spans ~24.8 kb of the genome. proliferation and melanocyte cell death. Defects in this gene cause oculocutaneous albinism type III; Transcription OCA III (also known as rufous oculocutaneous The gene encodes a 2876 bp mRNA.
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[Clone TYRP1/3280] (V8145)
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