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Institute of Genetics & Molecular & Cellular Biology 2o10 InstItute of GenetIcs & Molecular & cellular BIoloGy contents Foreword 2 Academics 4 Development & Stem Cells 6 Cancer & Functional Genomics 34 Integrated Structural Biology 62 Translational Medicine & Neurogenetics 80 ICS 100 Platforms 102 Core facilities 108 Facts & Figures 110 Staff scientists 112 Prizes & Distinctions 116 Publications until June 2010 117 Publications 2009 120 Where we are 126 Olivier Pourquié, IGBMC Director The IGBMC is one of the leading centers in bio- that are directly interested in biological questions logical research in Europe. It was founded in 1994 with immediate clinical relevance, such as human by Pierre Chambon, one of the world’s leading genetic diseases. figures in biomedical sciences. With its 768 staff One of IGBMC’s major assets are its excellent the Institute represents one of the largest French core facilities and its outstanding technological biomedical research units associating INSERM, platforms, which provide accessible state of the CNRS and the University of Strasbourg. The art technologies to the institute’s scientists. One IGBMC is located close to Strasbourg, a cosmo- of these platforms, the Mouse Clinical Institute politan city hosting the European parliament on (ICS), is rather unusual in that it is a large struc- the frontier between France and Germany. ture employing more than 100 The IGBMC is a highly international center with people exclusively dedicated to 43 Groups 48 different nationalities represented among its mouse technology. Its activities 106 Staff scientists personnel and all activities in the Institute are car- range from transgenic mouse ried out in English. models production to complex 121 Postdoctoral fellows The 43 independent research teams work on a phenotyping strategies inclu- 118 PhD students broad array of topics, ranging from the analysis of ding behavioral and metabolic 37 Master students protein structure to human genetics. The research analyses. In the following pages themes are organised into the following four you will find an overview of 293 Engineers & Technicians transversal Programmes. The Integrated Structural IGBMC’s broad range of re- Biology Programme consists of teams studying the search activities and technology 93 Administrators & General services structure of proteins using a variety of approaches support, highlighting our sti- ranging from diffraction analysis and computer mulating environment which modeling to state of the art electron microscopy. aims to foster excellent training The Programme Functional Genomics and Cancer and cross-discipline collabora- is centered on the analysis of the regulation of gene tions. < expression and epigenetics. Several groups in this Programme are also interested in the deregulation of these mechanisms that often lead to cancer. The Foreword Programme Development and Stem Cells brings to- With the ambition of creating a European centre of excel- lence in medical research, the IGBMC was founded by gether research groups interested in the formation Pierre Chambon and installed on its present site in 1994 of the embryo and in stem cell biology in a variety with the assistance of INSERM, CNRS, the University of model systems. Within this Programme, we of Strasbourg and the American laboratories of Bristol also see an interface emerging with the physical Myers-Squibb (BMS). Between 2002 and 2009, following on from Pierre Chambon, the Direction of the IGBMC sciences, associating physicists and cell biologists was assured by Dino Moras and Jean-Louis Mandel, two in the study of complex processes such as mor- scientists of international reputation. phogenesis. The Programme Translational Medi- In October 2009, Olivier Pourquié, a pioneer in research cine and Neurogenetics links all the research teams on muscles and skeletal development, elected to return to France to lead the IGBMC, following several years spent in the United States at the Howard Hughes Medical Ins- titute. His principal objective is to confirm and strengthen the status of the IGBMC on the national and international scientific stage. 3 academics academics ● Students & Post-docs Board • Seminars: We organize career development seminars for our community. With its recently launched International PhD Since October 2004, the Students and Post-Docs • Guides: Three guides have been developed to Programme, the IGBMC successfully attracts and Board (SPB) of the IGBMC has been working actively facilitate a newcomers’ life: a welcome guide, living recruits outstanding students from around the to promote and enhance the scientific and social ex- in Strasbourg, information guide about the University world via a call for applications. In this framework, change between the students and post-docs of the Ins- and the Graduate School and fellowships. we provide dedicated scientific and socio-professio- titute, the scientific programmes, the core facilities as International Cine-Club: nal training to our students, in accordance with the well as the platforms. It also links IGBMC’s students/ • Launched in December Graduate School. The training benefits notably from post-docs with the Direction, and the Life Sciences 2007, the Cine-Club invites staff to discover and the excellent scientific environment and is tailored to Graduate School of the University of Strasbourg. After learn from cultures that are represented at IGBMC. the needs of the students. The courses typically co- six years of continual growth and improvement, the Movies are selected and introduced by a student/post- ver all areas of modern biology and state-of-the art SPB has become an important partner working in a doc from abroad that is willing to share some cultural technologies offered at the Institute. The training of close relationship with the IGBMC administration. aspects about his or her country. our students is further enriched by a great diversity of • French and English lunches: Once a month, the SPB additional activities, of which a flavor is given here: arranges a lunch to allow participants to practice their • Special Seminar Series: Eminent international language skills: speaking either French with native scientists are invited to give a lecture as part of the French speakers or English with English natives. IGBMC Special Seminar Series. • Social events: The SPB often organizes parties and • Lunches with prominent scientists: Students have ● Training at IGBMC sport events to bring together students and post-docs the opportunity to lunch with the Special Seminar to strengthen bonds and to promote interactions in a speakers in an informal setting. As one of the leading European centers for biomedi- different setting. • Student Special Lecture: Students have the cal research, the IGBMC provides an outstanding re- • Retreats: In June 2010, the SPB organized the first opportunity to invite an outstanding scientist to give search and training environment. With 239 students retreat for students and post-docs in a relaxed setting the Student Special Lecture. and post-docs from over 40 countries, we offer a very in the Vosges Mountains.< lively and dynamic setting, fostering interactions at • Internal seminars and retreats: Internal seminars give the IGBMC and beyond. students and post-docs the opportunity to present all The SPB organizes the following activities: of their work to IGBMC. Retreats organized by the The IGBMC accepts about 37 Master Students and scientific Programme offer a more informal setting to • Poster sessions: On a monthly basis, students and The International PhD Programme 25 PhD students annually, who are exposed to the present findings and to discuss and share knowledge post-docs present their research projects. Staff from Programme Coordination: Dr. Astrid Lunkes with more senior scientists. PhD Programme Committee: latest technological developments and are trained un- core facilities and platforms are also invited to present Dr. Elisabeth Georges-Labouesse, Dr. Sophie Jarriault, der the supervision of IGBMC group leaders across • Award: Each year, a student is awarded a travel their activities. Dr. Hélène Puccio, Dr. Evi Soutoglou, Dr. Laszlo Tora, Dr. Bernardo Reina-San-Martin, Dr. Marat Yusupov the Institute’s broad range of research fields. The stu- fellowship to attend a scientific meeting. • Scientific workshops: Three workshops are organized dents are generally enrolled at the Life Sciences Gra- Student affairs: Dr. Katia Befort • International meetings: Scientific meetings are every year with the assistance of platforms and The PhD Programme Administrator: Laetitia Gonzalez duate School of the University of Strasbourg, which organized on a regular basis and provide our younger researchers of the Institute. Topics includes: Microarray oversees the thesis progress and delivers the PhD cer- Students & Post-doc Board researchers with the opportunity to meet outstanding Analysis; Bioinformatics in the post-genomics area; Coordination & communication: Irène Yujnovsky tificate. Several IGBMC researchers teach at the Uni- speakers from different fields. 3D Structure Visualization and Functional Genomics. Workshop: Fabrice Klein versity, including the medical school, thereby promo- Two of these workshops have been part of the training Alumni & guides: Pierre Antony, Johann Boehm ting links between the University and IGBMC. Information package: Angelita Simonetti, within the IGBMC International PhD Programme Thomas Hussenet since 2009. Web site: Florent Colin, Pierre-Eric Lutz Poster sessions: Thomas Daniel, Jérôme Mastio, Adrien Rousseau Events: Sara
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