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(12) United States Patent (10) Patent No.: US 9,572,800 B2 Zarnitsyn Et Al

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(12) United States Patent (10) Patent No.: US 9,572,800 B2 Zarnitsyn Et Al USOO9572800B2 (12) United States Patent (10) Patent No.: US 9,572,800 B2 Zarnitsyn et al. (45) Date of Patent: Feb. 21, 2017 (54) METHODS AND DEVICES FOR THE A61K 31/573; A61K 2300/00; A61 K TREATMENT OF OCULAR DISEASES IN 2039/505; A61K 2039/54: A61K 45/06; HUMAN SUBJECTS A61K 47/12: A61K 47/26: A61K 47/38: A61 K9/0019; A61 K9/10; A61M (71) Applicant: Clearside Biomedical, Inc., Alpharetta, 2037/0023; A61M 37/0015; C07K 16/22 GA (US) See application file for complete search history. (72) Inventors: Vladimir Zarnitsyn, Atlanta, GA (US); (56) References Cited Samirkumar Patel, Atlanta, GA (US); Daniel White, Suwanee, GA (US); U.S. PATENT DOCUMENTS Glenn Noronha, Atlanta, GA (US); 2,187,259 A 1/1940 Barnhart Brian Burke, Cary, NC (US); Jennifer 3,477,432 A 11, 1969 Shaw Kissner, Alpharetta, GA (US) (Continued) (73) Assignee: CLEARSIDE BIOMEDICAL, INC., Alpharetta, GA (US) FOREIGN PATENT DOCUMENTS CN 1706365 12/2005 (*) Notice: Subject to any disclaimer, the term of this CN 1736474 2, 2006 patent is extended or adjusted under 35 (Continued) U.S.C. 154(b) by 0 days. OTHER PUBLICATIONS (21) Appl. No.: 15/086,485 Office Action for U.S. Appl. No. 1 1/743,535, mailed Aug. 19, 2010, (22) Filed: Mar. 31, 2016 7 pages. (65) Prior Publication Data (Continued) US 201670213662 A1 Jul. 28, 2016 Primary Examiner — Aradhana Sasan (74) Attorney, Agent, or Firm — Cooley LLP Related U.S. Application Data (57) ABSTRACT (63) Continuation of application No. 15/001,610, filed on Jan. 20, 2016, which is a continuation of application Methods and devices are provided for targeted non-Surgical administration of a drug formulation to the Suprachoroidal (Continued) space (SCS) of the eye of a human subject for the treatment (51) Int. C. of a posterior ocular disorder or a choroidal malady. In one A6 IK 9/00 (2006.01) embodiment, the method comprises inserting a hollow A6 IK 9/10 (2006.01) microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into (Continued) the suprachoroidal space of the eye, wherein the infused (52) U.S. C. drug formulation flows within the Suprachoroidal space CPC ......... A6 IK3I/4439 (2013.01); A61K 9/0019 away from the insertion site during the infusion. In one (2013.01); A61K 9/0048 (2013.01); embodiment, the fluid drug formulation comprises drug (Continued) nanoparticles or microparticles. (58) Field of Classification Search CPC ... A61K 31/4439; A61 K 9/0048: A61 K 9/16; 13 Claims, 40 Drawing Sheets 35tawitreat 338cios eit to figst to each; 83; US 9,572,800 B2 Page 2 Related U.S. Application Data D383,049 S 9, 1997 Concari et al. 5,667,491 9, 1997 Pliquett et al. No. 14/.441,151, filed as application No. PCT/ 5,681,825 10, 1997 Lindqvist et al. US2013/069156 on Nov. 8, 2013. 5,766.242 6, 1998 Wong et al. 5,767,079 6, 1998 Glaser et al. 5,788,679 8, 1998 Gravlee, Jr. (60) Provisional application No. 61/898,926, filed on Nov. 5,792,099 8, 1998 DeCamp et al. 1, 2013, provisional application No. 61/873,660, filed 5,817,075 10, 1998 Giungo on Sep. 4, 2013, provisional application No. 5,824,072 10, 1998 Wong 5,911,223 6, 1999 Weaver et al. 61/819,388, filed on May 3, 2013, provisional 5,952,378 9, 1999 Stjernschantz et al. application No. 61/785,229, filed on Mar. 14, 2013, 5,968,022 10, 1999 Saito provisional application No. 61/773,124, filed on Mar. 6,083,199 T/2000 Thorley et al. 5, 2013, provisional application No. 61/745,237, filed 6,280,470 8, 2001 Peyman on Dec. 21, 2012, provisional application No. 6,299,603 10, 2001 Hecker et al. 6,309,347 10, 2001 Takahashi et al. 61/734,872, filed on Dec. 7, 2012, provisional 6,309,374 10, 2001 Hecker et al. application No. 61/724,144, filed on Nov. 8, 2012. 6,319,240 11/2001 Beck 6,334,856 1, 2002 Allen et al. (51) Int. C. 6,378,526 4, 2002 Bowman et al. A6 IK 9/16 (2006.01) 6,387,078 5/2002 Gillespie, III A 6LX 3/573 (2006.01) 6,397,849 6, 2002 Bowman et al. 6.432,090 8, 2002 Brunel A6 IK 3/4439 (2006.01) 6,503,231 1, 2003 Prausnitz et al. A6 IK 39/00 (2006.01) 6,524,581 2, 2003 Adamis A6 IK 45/06 (2006.01) 6,540,725 4/2003 Ponzi A6 IK 47/12 (2006.01) 6,551,299 4/2003 Miyoshi et al. 6,611,707 8, 2003 Prausnitz et al. A6 IK 47/26 (2006.01) 6,743,211 6, 2004 Prausnitz et al. A6 IK 47/38 (2006.01) 6,773.916 8, 2004 Thiel et al. A6M 37/00 (2006.01) D499,153 11/2004 Kuo C07K 6/22 (2006.01) 6,883.222 4, 2005 Landau U.S. C. 6,918,889 7/2005 Brunel (52) 6,929,623 8, 2005 Stone CPC .................. A61K 9/10 (2013.01); A61K 9/16 6,936,053 8, 2005 Weiss (2013.01); A61 K3I/573 (2013.01); A61 K 7,025,774 4, 2006 Freeman et al. 45/06 (2013.01); A61K 47/12 (2013.01); A61 K 7,150,735 12, 2006 Hickle 7,207,965 4, 2007 Simon 47/26 (2013.01); A61K 47/38 (2013.01); 7,207,980 4, 2007 Christian et al. A61M 37/0015 (2013.01); C07K 16/22 7,211,062 5/2007 Kwon (2013.01); A6 IK 2039/505 (2013.01); A61 K 7,214,212 5/2007 Pommereau et al. 2039/54 (2013.01); A61M 2037/0023 7,226,439 6, 2007 Prausnitz et al. (2013.01); A61M 2037/0061 (2013.01) 7,316,676 1, 2008 Peyman et al. 7,425,207 9, 2008 Miller et al. References Cited 7.468,057 12, 2008 Ponzi (56) D590,690 4/2009 Bertini D598.543 8, 2009 Vogel et al. 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