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Erectile Dysfunction and Premature Ejaculation
GUIDELINES ON MALE SEXUAL DYSFUNCTION: Erectile Dysfunction and Premature Ejaculation (Text update April 2014) K. Hatzimouratidis (chair), I. Eardley, F. Giuliano, D. Hatzichristou, I. Moncada, A. Salonia, Y. Vardi, E. Wespes Eur Urol 2006 May;49(5):806-15 Eur Urol 2010 May;57(5):804-14 Eur Urol 2012 Sep;62(3):543-52 ERECTILE DYSFUNCTION Definition, epidemiology and risk factors Erectile dysfunction (ED) is the persistent inability to attain and maintain an erection sufficient to permit satisfactory sex- ual performance. Although ED is a benign disorder, it affects physical and psychosocial health and has a significant impact on the quality of life (QoL) of sufferers and their partners. There is increasing evidence that ED can be an early mani- festation of coronary artery and peripheral vascular disease; thus, ED should not be regarded only as a QoL issue but also as a potential warning sign of cardiovascular disease includ- ing lack of exercise, obesity, smoking, hypercholesterolaemia, and the metabolic syndrome. The risk of ED may be reduced by modifying these risk factors, particularly taking exercise or losing weight. Another risk factor for ED is radical prostatec- tomy (RP) in any form (open, laparoscopic, or robotic) because of the risk of cavernosal nerve injury, poor oxygenation of the corpora cavernosa, and vascular insufficiency. 130 Male Sexual Dysfunction Diagnosis and work-up Basic work-up The basic work-up (minimal diagnostic evaluation) outlined in Fig. 1 must be performed in every patient with ED. Due to the potential cardiac risks associated with sexual activity, the three Princeton Consensus Conference stratified patients with ED wanting to initiate, or resume, sexual activity into three risk categories. -
Delayed Ejaculation & Anorgasmia
Delayed ejaculation & anorgasmia EMMANUELE A. JANNINI Chair of Endocrinology & Sexual Medicine Tor Vergata University of Rome, Italy It Soc Androl & Sex Med – President-elect Taxonomy of ejaculatory disorders Epidemiology of ejaculatory disorders 25 a) timing 20 – PREMATURE EJACULATION 15 – DELAYED EJACULATION 10 Percentage 5 b) modality 0 E N IA R PE DE IO M AS ‐ RETROGRADE EJACULATION LAT G U R O JAC ‐ ANEJACULATION (impotentia ejaculationis) E AN AN Taxonomy of ejaculatory disorders • EMISSION PHASE DISORDERS: – Retrograde ejaculation • EJACULATION PHASE DISORDERS: – Premature ejaculation – Deficient ejaculation: • Delayed ejaculation • Anejaculation • ORGASM DISORDERS: – Anorgasmia – Postorgasmic illness syndrome Standard Operating Procedures (SOP) in Diagnosis and Treatment of Delayed Ejaculation/Anejaculation ISSM Standards Committee Meeting June 23-25, 2010 Hotel Agneshof Nürnberg, Germany Pierre Assalian Canada Emmanuele A. Jannini Italy Chris G McMahon (Chairman) Australia David Rowland USA Marcel Waldinger (Chairman) The Netherlands DELAYED EJACULATION Delayed ejaculation • Much less frequent than PE • A rare reason for medical help seeking • Underdiagnosed • Undertreated Is DE a disease? • girls are happy… …where is the problem? …but girls are not happy… Why so poor science? • Low prevalence • Few studies • Classically considered A new psychogenic in nature • Classically treated with behavioral therapies challenge • Definition(s) lacking • Etiologies largely unknown for • Pathogenesis obscure • Lack of awareness and Sexual acknowledgements -
Male Anorgasmia: from “No” to “Go!”
Male Anorgasmia: From “No” to “Go!” Alexander W. Pastuszak, MD, PhD Assistant Professor Center for Reproductive Medicine Division of Male Reproductive Medicine and Surgery Scott Department of Urology Baylor College of Medicine Disclosures • Endo – speaker, consultant, advisor • Boston Scientific / AMS – consultant • Woven Health – founder, CMO Objectives • Understand what delayed ejaculation (DE) and anorgasmia are • Review the anatomy and physiology relevant to these conditions • Review what is known about the causes of DE and anorgasmia • Discuss management of DE and anorgasmia Definitions Delayed Ejaculation (DE) / Anorgasmia • The persistent or recurrent delay, difficulty, or absence of orgasm after sufficient sexual stimulation that causes personal distress Intravaginal Ejaculatory Latency Time (IELT) • Normal (median) à 5.4 minutes (0.55-44.1 minutes) • DE à mean IELT + 2 SD = 25 minutes • Incidence à 2-11% • Depends in part on definition used J Sex Med. 2005; 2: 492. Int J Impot Res. 2012; 24: 131. Ejaculation • Separate event from erection! • Thus, can occur in the ABSENCE of erection! Periurethral muscle Sensory input - glans (S2-4) contraction Emission Vas deferens contraction Sympathetic input (T12-L1) SV, prostate contraction Bladder neck contraction Expulsion Bulbocavernosus / Somatic input (S1-3) spongiosus contraction Projectile ejaculation J Sex Med. 2011; 8 (Suppl 4): 310. Neurochemistry Sexual Response Areas of the Brain • Pons • Nucleus paragigantocellularis Neurochemicals • Norepinephrine, serotonin: • Inhibit libido, -
Premature Ejaculation: a Clinical Review for the General Physician
CLINICAL Premature ejaculation: A clinical review for the general physician Eric Chung, Brent Gilbert, Marlon Perera, Matthew J Roberts Background remature ejaculation is one of the ejaculatory latency time (IELT). The most common sexual dysfunctions, IELT is defined as the time from vaginal Premature ejaculation is one of the most P affecting up to 21–31% of the penetration to ejaculation. Lifelong common sexual dysfunctions in men. Australian adult male population, premature ejaculation is characterised Recent epidemiological studies suggest irrespective of their age, marital status or by an IELT of <1 minutes since first its prevalence in Australia may range ethnicity.1–5 This sexual condition is likely intercourse, whereas IELT of <3 minutes from 21–31%. to be under-reported and under-treated at any point in a man’s life is considered 12 Objective because of the patients’ perceived shame to be acquired premature ejaculation. and low self-esteem. This is in addition to Premature ejaculation can be further This article will discuss the current many physicians feeling uncomfortable divided into authority-based subtypes definition of premature ejaculation from or uncertain about the management ‘variable’ and ‘subjective’ (Table 1), a urological perspective. It will provide of premature ejaculation.6,7 The impact which describe individuals experiencing an understanding of the pathogenesis of premature ejaculation is mostly felt significant distress and dissatisfaction of premature ejaculation, as well as psychologically and in interpersonal with ejaculation.12 assessment and management options. relationships.8 Men with premature ejaculation often experience significant Pathophysiology and Discussion psychological distress, avoid physical and associations Premature ejaculation can have a emotional intimacy, and become victims Psychological components often significant adverse effect on the quality of false medical advertisings and unproven contribute to acquired premature of life for the patient and his sexual medical management.8 –11 ejaculation. -
HIV and Sexual Dysfunction in Men
Journal of Clinical Medicine Review HIV and Sexual Dysfunction in Men Sara De Vincentis 1,2 , Giulia Tartaro 1,2, Vincenzo Rochira 1,2,* and Daniele Santi 1,2 1 Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giardini 1355, 41126 Modena, Italy; [email protected] (S.D.V.); [email protected] (G.T.); [email protected] (D.S.) 2 Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero-Universitaria of Modena, 41126 Modena, Italy * Correspondence: [email protected]; Tel.: +39-059-396-2453; Fax: +39-059-396-1335 Abstract: Sexual issues tend to go unaddressed in human immunodeficiency virus (HIV) man- agement, although overt sexual dysfunctions are more prevalent in people living with HIV than uninfected people. Erectile dysfunction is the most frequent sexual problem, with a prevalence of 30–50% even in men <40 years of age, but other issues such as loss of libido and ejaculatory disorders should not be overlooked. Peculiar factors related to HIV infection (e.g., fear of virus transmission, changes in body image, HIV-related comorbidities, HIV distress and stigma), alongside classical factors non-related to HIV, should be considered when approaching sexual problems in HIV patients. For this reason, the diagnostic and therapeutic workout of sexual dysfunction in the context of HIV requires a multidisciplinary approach, involving specialists in both infectious diseases and sexual medicine. This narrative review presents an overview of current knowledge on sexual dysfunction in HIV men, deepening the factors driving and taking part in these issues, providing advice for the clinical approach, and underlining the importance of caring for sexual health to improve the quality of life of HIV patients. -
Delayed Ejaculation* Cal Disease May Also Play a Role in DE
Patient Highlights JSMInformation about sexual health issues & treatments © 2013 International Society for Sexual Medicine What Causes DE? Physical causes may account for DE, as any procedure or disease that disrupts the nervous systems path to the genitals (spinal cord injury, multiple sclerosis, pelvic-region surgery, severe diabetes, alcoholism, etc.) has the potential to inter- fere with ejaculation and orgasm. It is frequently useful for a doctor to conduct a physical examination and medical history that may identify problems (such as reversible ure- thral, prostatic, epididymal, and testicular infections) as well as hormonal (androgen, etc.) contributory factors. A number of drugs may cause DE. Common culprits include drugs for high blood pressure, antidepressants, antipsychotic drugs, and some drugs that are used to treat prostate growth or baldness. Decreased sensation of the penis (often associated with aging) may also be a factor. Finally, there is increasing evidence that some men have natural variation in their ejacu- lation latency (how long they last during sex) and this may lead to DE-like problems for some couples. What Biological Factors may Play a Role in DE? Many believe that DE is a neurobiological variation of a “normal” ejaculatory statistical distribution curve. It is known from studies in animals as well as humans from around the world that there is a great variation between couples in how long sexual intercourse lasts. Some of these differences may be cultural, but there is increasing evidence that predisposing genetic factors have an effect on the speed and ease of ejaculation by modulating brain chemicals and a variety of biological mechanisms that control ejaculation. -
Childhood Sexual Abuse and Erectile Dysfunction in Gay And
CHILDHOOD SEXUAL ABUSE AND ERECTILE DYSFUNCTION IN GAY AND BISEXUAL MEN: THE ROLE OF SUBSTANCE USE, EMOTION DYSREGULATION, AND COPING STRATEGIES by Marie Faaborg-Andersen Bachelor of Arts, Concordia University, Montreal, Quebec, 2012 A thesis presented to Ryerson University in partial fulfillment of the requirements for the degree of Master of Arts in the Program of Psychology Toronto, Ontario, Canada, 2015 © Marie Faaborg-Andersen, 2015 AUTHOR’S DECLARATION FOR ELECTRONIC SUBMISSION OF A THESIS I hereby declare that I am the sole author of this thesis. This is a true copy of the thesis, including any required final revisions, as accepted by my examiners. I authorize Ryerson University to lend this thesis to other institutions or individuals for the purpose of scholarly research. I further authorize Ryerson University to reproduce this thesis by photocopying or by other means, in total or in part, at the request of other institutions or individuals for the purpose of scholarly research. I understand that my thesis may be made electronically available to the public. ii Abstract Childhood sexual abuse and sexual dysfunction in gay and bisexual men: The role of substance use, emotion dysregulation, and coping strategies Master of Arts, 2015 Marie Faaborg-Andersen Psychology, Ryerson University Sexual dysfunction has been associated with considerable mental health and interpersonal problems. Gay and bisexual men report a higher rate of sexual dysfunction and childhood sexual abuse (CSA) compared to heterosexual men. The relationship between CSA and adult sexual health problems has been well established; however, the pathways leading from CSA to erectile dysfunction are poorly understood. -
Crossover Sexual Offenses. Abstract
Crossover sexual offenses. Heil P1, Ahlmeyer S, Simons D. Abstract Crossover sexual offenses are defined as those in which victims are from multiple age, gender, and relationship categories. This study investigates admissions of crossover sexual offending from sex offenders participating in treatment who received polygraph testing. For 223 incarcerated and 266 paroled sexual offenders, sexual offenses were recorded from criminal history records and admissions during treatment coupled with polygraph testing. The majority of incarcerated offenders admitted to sexually assaulting both children and adults from multiple relationship types. In addition, there was a substantial increase in offenders admitting to sexually assaulting victims from both genders. In a group of incarcerated offenders who sexually assaulted children, the majority of offenders admitted to sexually assaulting both relatives and nonrelatives, and there was a substantial increase in the offenders admitting to assaulting both male and female children. Although similar trends were observed for the sample of parolees, the rates were far less dramatic. Parolees appeared to have greater levels of denial, had participated in fewer treatment sessions, and perceived greater supervision restrictions as a result of admitting additional offenses. These findings support previous research indicating that many sexual offenders do not exclusively offend against a preferred victim type. Multiple Paraphilic Diagnoses among Sex Offenders Gene G. Abel, MD; Judith V. Becker, PhD; Jerry Cunningham-Rathner, BA; Mary Mittelman, DrPH; and Joanne-L. Rouleau, PhD The psychiatric literature suggests that paraphiliacs can be expected to partic- ipate in only one type of deviant sexual behavior. Using self-reports gathered with assured confidentiality from 561 nonincarcerated paraphiliacs, we discovered that most paraphiliacs have had significant experience with as many as ten different types of deviant sexual behavior without regard, in many cases, to gender, age, and familial relationship of the victim. -
SELECTIVE SEROTONIN REUPTAKE INHIBITORS SEXUAL FUNCTION K. Demyttenaere0 and D. Vanderschueren" University Hospital Gasthui
* 1995 Elsevier Science B. V. All rights reserved. The Pharmacology of Sexual Function and Dysfunction J. Bancroft, editor 327 SELECTIVE SEROTONIN REUPTAKE INHIBITORS AND SEXUAL FUNCTION K. Demyttenaere0 and D. Vanderschueren" University Hospital Gasthuisberg (K.D. Leuven) ° Department of Psychiatry and Institute for Family and Sexological Sciences " Department of Endocrinology - Andrology Unit Herestraat 49 - B 3000 Leuven, Belgium dedicated to dr. Hugo De Cuyper (18.1.1946 - 13.9.1994) Introduction Selective Serotonin Reuptake Inhibitors (SSRIs : fluvoxamine -Floxyfral® or Fevarin®-, fluoxetine -Prozac®-, sertraline - Serlain® or Zoloft®-, paroxetine -Seroxat® or Paxil®- and citalopram -Cipramil®-) are potent and competitive inhibitors of the high affinity neuronal re-uptake mechanism for serotonin. These drugs also inhibit the re-uptake of noradrenaline and, generally to a lesser extent, dopamine, at higher concentrations. Paroxetine is the most potent serotonin uptake inhibitor in vitro of the drugs investigated, and citalopram is the most selective inhibitor of serotonin re-uptake, with paroxetine being more selective than fluoxetine, fluvoxamine and sertraline. Of the drugs investigated, only sertraline is a more potent inhibitor of dopamine compared with noradrenaline uptake. SSRIs are not only as effective as the tricyclic antidepressants in the treatment of major depression but are also effective in the treatment of obsessive-compulsive disorder, panic disorder, eating disorders and premenstrual syndrome (1). Although the latency of onset to therapeutic response seems to be somewhat longer, most psychiatrists consider SSRIs the initital drug of choice in the treatment of depressive disorders. Indeed, these drugs are usually better tolerated since they do not produce muscarinic, histaminic and alpha adrenergic side effects. -
Sex Disorders & Paraphilias
Lecture 7: Sex disorders & Paraphilias: Exhibitionism and Frotteuerism What is normal? Difficulty in defining normal? – Bias in self-reports/clinical impressions Sexual dysfunctions – Disruption to ‘normal’ sexual response cycle Masters and Johnston’s & Kaplan’s model: - Desire phase - Excitement phase - Orgasmic phase - Resolution phase Should be: persistent & recurrent. Cause clinically significant distress. Not due to medical condition/other psychological illness. Present: during masturbation + sexual activity Specifiers used to designate onset: - Lifelong - Acquired - Generalised - Situational Types of disorders – Interest, desire & arousal: Male hypoactive sexual desire disorder, erectile disorder. Female sexual interest/arousal disorder Orgasm: delayed ejaculation, premature, female orgasmic disorder Pain: Genito-pelvic pain/penetration disorder (female) Disorders of interest, desire & arousal – Female sexual interest/Arousal disorder – Diminished, absent, or reduced frequency of at least 3 of the following: - Interest in sexual activity - Sexual/erotic thoughts or fantasies - Initiation of sexual activity & responsiveness to partner’s attempts to inititate - Sexual excitement/pleasure - >75% of sexual encounters - Sexual interest/arousal elicited by any internal or external erotic cues - Genital/nongenital sensations - >75% sexual encounters Male Hypoactive Sexual Desire Disorder – Persistently deficient or absent sexual fantasies & desires, as judged by clinician Considerations – age, general/socio-cultural contexts. -
Psychosexual Therapy for Delayed Ejaculation Based on the Sexual Tipping Point Model
Review Article Psychosexual therapy for delayed ejaculation based on the Sexual Tipping Point model Michael A. Perelman Human Sexuality Program, NY Weill Cornell Medical Center, New York, USA Correspondence to: Michael A. Perelman. 70 E 77th St., New York, USA. Email: [email protected]. Abstract: The Sexual Tipping Point® (STP) model is an integrated approach to the etiology, diagnosis and treatment of men with delayed ejaculation (DE), including all subtypes manifesting ejaculatory delay or absence [registered trademark owned by the MAP Educational Fund, a 501(c)(3) public charity]. A single pathogenetic pathway does not exist for sexual disorders generally and that is also true for DE specifically. Men with DE have various bio-psychosocial-behavioral & cultural predisposing, precipitating, maintaining, and contextual factors which trigger, reinforce, or worsen the probability of DE occurring. Regardless of the degree of organic etiology present, DE is exacerbated by insufficient stimulation: an inadequate combination of “friction and fantasy”. High frequency negative thoughts may neutralize erotic cognitions (fantasy) and subsequently delay, ameliorate, or inhibit ejaculation, while partner stimulation (friction) may prove unsatisfying. Assessment requires a thorough sexual history including inquiry into masturbatory methods. Many men with DE engage in an idiosyncratic masturbatory style, defined as a masturbation technique not easily duplicated by the partner’s hand, mouth, or vagina. The clinician’s most valuable diagnostic tool is a focused sex history (sex status). Differentiate DE from other sexual problems and review the conditions under which the man can ejaculate. Perceived partner attractiveness, the use of fantasy during sex, anxiety- surrounding coitus and masturbatory patterns require meticulous exploration. -
The Potential Associations of Pornography Use with Sexual Dysfunctions: an Integrative Literature Review of Observational Studies
Journal of Clinical Medicine Review The Potential Associations of Pornography Use with Sexual Dysfunctions: An Integrative Literature Review of Observational Studies Aleksandra Diana Dwulit and Piotr Rzymski * Department of Environmental Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland * Correspondence: [email protected]; Tel.: +48-61854-7604 Received: 30 May 2019; Accepted: 24 June 2019; Published: 26 June 2019 Abstract: This paper reviews the associations between pornography use and sexual dysfunction based on evidence from observational studies. The existing data in this regard mostly derive from cross-sectional investigations and case reports. There is little if no evidence that pornography use may induce delayed ejaculation and erectile dysfunction, although longitudinal studies that control for confounding variables are required for a full assessment. The associations between pornography use and sexual desire may differ between women and men although the existing data is contradictory and causal relationships cannot be established. The strongest evidence is available for the relation of pornography use with decreased sexual satisfaction, although the results of prospective studies are inconsistent. The paper outlines future research prospects beneficial in understanding the nature of associations between pornography use and sexual dysfunctions in men and women. Keywords: pornography; sexual dysfunction; erectile dysfunction; delayed ejaculation; sexual desire; sexual satisfaction 1. Introduction The existing literature provides a number of varying descriptions of the term pornography. According to the Final Report of the Attorney General’s Commission on Pornography, it can be defined as any material that is predominantly sexually explicit and intended primarily for the purpose of sexual arousal [1]. Currently, pornography represents an important economic venture [2,3].