Annual Report 2012 - 2013 Cancer Research Wales - the people of Wales’ charity. Cancer Research Wales – All money raised is spent in Wales 1 Board of Trustees and Ocials Registered Charity No. Shop Support 248767 (1966) Mr Berian Richards Registered Oce Mr Roger Smith Cancer Research Wales Patrons Velindre Cancer Centre Jamie Baulch Velindre Road Huw Edwards Whitchurch Richard Elis Cardi Tonya Smith CF14 2TL Nigel Walker Telephones CRW Chair of Clinical Oncology Fundraising Oce 029 2031 6976 Professor Malcolm Mason Registered Oce 029 2031 6283 Board of Trustees Fax 029 2031 6927 Professor John L. Moore (President) Email Dr John Pritchard C.B.E (Chairman) [email protected] Dr Malcolm Adams Web (Chairman of Scientic & Research Committee) www.cancerresearchwales.co.uk Mrs Mary Andrews Charity Director Dr Colin S. Askill resigned October 2012 Miss Liz Andrews Mr Michael A.C. Brooke resigned October 2012 Deputy Charity Director Mr R Nevil Davies Mrs Coleen Watkins Dr Chris C. Ganey Professor Bharat Jasani Scientic Projects Manager Mr Peter J. Keneally Dr Lee Campbell Mr Gavin Moore Commercial Manager Mrs Gill Owens Mrs Pamela Perkins Mrs Beryl Rees Fundraising Manager Mr Bryn Roberts Miss Laura Hooper (Fundraising Committee Chairman) Fundraiser resigned May 2013 Mrs Wendy Collie Mr Jerey R. Thomas F.C.A A.T.T.I. Financial Administrator (Hon Treasurer) Mrs Gillian Hall Mr Peter Weber (Hon Legal Advisor) Finance/Administration Assistants Auditors Mrs Sharon Bonetto Watts Gregory LLP Miss Ruth Davies Elfed House Legacy Ocer Oak Tree Court Mrs Helen Jereys Mulberry Drive Shop Managers Cardi Gate Business Park Ms Sarah Callow Cardi CF23 8RS Mrs Karen O’Brien Bankers Mrs Julia Simon Unity Trust Bank CAF Bank Ms Stephanie Tanner Nine Brindley Place PO Box 289 Mrs Deborah Drew Birmingham B1 2HB West Malling Kent ME19 4TA i Cancer Research Wales – All money raised is spent in Wales Chairman’s Message The current economic situation remains dicult for many people, but it is important to highlight that the support for Cancer Research Wales continues to grow. This enables the charity to fund an increasing number of highly rated peer reviewed research projects. Examples of the diverse nature of the research are contained in this report. The CRW Symposium held in March 2013 with the theme, ‘Towards Personalised Cancer Treatment’, hosted by Sian Lloyd was a huge success. This was an opportunity for such as walking the perimeter of Wales. scientists, funded by CRW, to discuss their These examples serve to show the huge projects and results, with an audience of commitment and eort to raise money for varied backgrounds. The Symposium also CRW. We are very grateful for the enormous provided a platform for an announcement support the charity receives enabling us to that £1.5m would be made available for an allocate an additional £1m of new monies for important new project, ‘Stratied Medicine’, research projects in Wales. over the coming years. This project will aim to ensure that future cancer patients receive the I am sure that the demands to fund new most appropriate treatment for their cancer research will continue to grow. All requests for through targeted therapy; demonstrating funding will remain to be peer reviewed by CRW’s commitment to improving patient care external experts, ensuring that monies raised and outcome as a result of research. are spent on the best projects in Wales. The continued ability to fund new research Please continue to help us, through excellent activities by CRW is only possible because research, to improve treatment outcome and of the huge support by the people and quality of life in cancer care for patients in organisations of Wales; individually and Wales. corporately. For example the Principality Building Society’s Charity of the Year which raised £72,226; and the Farmers Union of Wales which raised £50,000. Furthermore the carrier bag scheme, supported by independent retailers and larger organisations, such as Poundland which raised £32,804 and individual activities Dr John Pritchard CBE Cancer Research Wales – All money raised is spent in Wales 3 Contents i Board of Trustees and Ocials 1 Chairman’s Message 3 Overview of Research - Professor M Mason 4 Overview of Cancer Research Wales Scientic Programme - Dr Malcolm Adams 5 Titles and Authors of Funded Projects 15 Cancer Research Wales Library 16 Fundraising Activities 21 Acknowledgements 40 Independent Auditors Report to the Trustees of Cancer Research Wales 42 Statement of Financial Activities 43 Balance Sheet 44 Summary: Income & Expenditure 4 Cancer Research Wales – All money raised is spent in Wales Overview of Research that the work undertaken on the programme grant will result in a better understanding of these processes and lead to the optimal use of these agents, in addition to the discovery of new drug targets. In the forthcoming year the Wales Cancer Bank will reach two very important milestones, namely, its 10th anniversary and the consenting of its 10,000th patient. To date over 60 dierent projects in the U.K and Europe have been approved samples as part of their studies. The promise of delivering personalised medicine for the treatment of cancer has not come without signicant challenges. We now understand how single tumours and their associated metastatic lesions evolve to develop dierent As Cancer Research Wales’ Chair of Clinical mutations during the course of the disease, Oncology, it has been a thrill to see the changes that may limit the use of single incredible strides that the charity has made agents developed to target specic genetic over the last few years. The breadth and depth defects. The Wales Cancer Bank is strategically of talent we have in Wales and the exciting positioned to tackle these important issues research that is taking place was clearly and help decipher the correct sequencing evident at the one-day science symposium or combination of these newer or indeed hosted by Cancer Research Wales in March conventional treatments, allowing the best for 2013. Many dierent topics were covered patients. A grant recently awarded by Cancer during the day which brought together Research Wales for the full characterisation of people from all backgrounds including cancer tumours will help achieve this goal. scientists, clinicians, radiologists and cancer Our profound thanks go to all the patients research nurses, highlighting just how and their families who kindly donated multidisciplinary cancer treatment and care samples, and the various NHS organisations has become. across Wales, who together make this The Cancer Research Wales programme grant ambitious project a success. We are continues to go from strength to strength, continually amazed and extremely grateful for with several of the scientists involved on the all the wonderful work our loyal supporters project receiving awards and recognition at continue to do for Cancer Research Wales, international conferences and workshops. even during the midst of a dicult economic The focus of this research is to understand the climate. This support helps toward achieving complex interplay that occurs between the our goal of reducing the impact of cancer on immune system and prostate cancer cells and the people of Wales through the funding of how this can lead to aggressive disease. This world class cancer research and education. work is very relevant since a number of new Professor Malcolm Mason drugs which seek to harness the power of the Cancer Research Wales immune system are currently being tested Chair of Clinical Oncology for metastatic prostate cancer. It is hoped Cardi University Cancer Research Wales – All money raised is spent in Wales 5 Overview of Cancer Research Wales Scientic Programme It was inspiring to see new projects added to the Cancer Research Wales research portfolio dealing with unmet clinical needs in myeloid leukaemia and ovarian cancer. Looking ahead we are pleased to launch a new scholarship in brain tumour research in memory of Mr Ed Evans who tirelessly raised funds for Cancer Research Wales until his sad death in 2007. Professor Malcolm Mason who holds the Cancer Research Wales Chair of Clinical Oncology, was honoured with the prestigious William Farr medal. This is awarded annually to medical practitioners who have made a signicant contribution to the treatment of elderly patients through original research It has been another excellent year for Cancer conducted in the U.K. Professor Mason received Research Wales, which culminated in our the award in recognition of the pioneering second Scientic Symposium held at the and practice changing clinical trials he helped SWALEC Stadium, Cardi, in March 2013 and lead in the eld of prostate cancer, trials which opened by the Health Minister, Ms Lesley improved survival by 8-10%. Griths. The event brought together some We are proud to invest in the future of Wales’ renowned cancer scientists and generations of cancer researchers in Wales clinicians providing an ideal forum to share and as a result currently fund a total of 30 results, ideas and form new collaborations. We PhD students and 9 post-doctoral scientists. very much look forward to staging the next Therefore, it gives me immense pleasure to say one in 2016 to mark the 50th anniversary of a big thank you to all our wonderful supporters the charity. who generously give both their time and The tremendous support we continue to money. Please browse through the abstracts receive from the public has meant that of the ground breaking research funded by Cancer Research Wales continues to grow. Cancer Research Wales. Work that is hoped will This year saw a grant awarded to the Wales make a real dierence to cancer patients and Cancer Bank, allowing the full molecular their families and which could not take place characterisation of thousands of individual without your support.