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Journal of Pharmacy and Pharmacology 1958 Volume.10 Suppl

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Journal of Pharmacy and Pharmacology 1958 Volume.10 Suppl The Journal of PHARMACY and PHARMACOLOGY Successor;sor to The Quarterly Journal o f Pharmacy and PharmacologyPharma 17 BLOOMSBURY SQUARE, LONDON, W.C.l Telephone: HOLborn 8967 Telegrams: Pharmakon, Westcent, London Editor: George Brownlee, D.Sc., Ph.D., F.P.S. Assistant Editor: J. R. Fowler, B.Pharm., F.P.S. CONTENTS BRITISH PHARMACEUTICAL CONFERENCE p a g e R eport o f Proceedings .......................................................................................... IT Chairman’s Address Modern Analytical Chemistry in the Service of Pharmacy and Medicine. By G. E. F o s t e r ..............................................................9 T Symposium E v a l u a t i o n o f N e w D r u g s . By L. G. Goodwin and F. L. Rose .. 24 T Science Papers and Discussions The Basis for “Sufficient of a Suitable Bacteriostatic” in Injec­ tions. By G. Sykes ..........................................................................40 T The Factors Influencing Sterilisation by Low Pressure Steam. Part I. Design and Instrumentation. By T. E. Barson, F. Peacock, E. L. Robins and G. R. Wilkinson .. .. .. .. .. 47 T The Factors Influencing Sterilisation by Low Pressure Steam. Part II. The Influence of Water Content of Cotton Gowns on Equilibrium Times. By T. E. Barson, F. Peacock, E. L. Robins and G. R. W ilk in s o n ..........................................................................56 T The Colorimetric D etermination of Morphine in G alenical Preparations. By C. A. Johnson and Cecilia J. Lloyd .. .. 60 T Some Observations Concerning the Chemical Reactions Occur­ ring Between Formaldehyde and Peptone. By Kenneth Bullock and V. Subba Rao .. .. .. .. .. .. 72 T The Effects of Added Peptone on the Bactericidal Action of Solutions of Formaldehyde. By Kenneth Bullock and V. Subba Rao ..................................................................................................82 T T he Stability o f Solutions o f 5-Hydroxytrytophan. By J. W. Hadgraft, Shirley A. P. Price and G. B. West .. .. .. .. 87 T Studies on 5-Hydroxytryptamine and 5-Hydroxytryptophan. By G. B. W e s t ......................................................................................92 T The P recision of some Procedures in Pharmaceutical Analysis. Part I. Use of a Pipette and a Burette. By A. R. Rogers .. .. 98 T N euromuscular B l o c k i n g A g e n t s . Part II. The Preparation and Properties of the Series of NSN- and NNN-Tris-ethonium Com­ pounds. By D. Edwards, J. J. Lewis, J. B. Stenlake and M. S. Zoha 106 T i ii T h e J o u r n a l or P h a r m a c y a n d P harmacology December, 1 9 5 8 CONTENTS page Science Papers and Discussions—(continued) N euromuscular Blocking Agents. Part III. Some Linear NNNN- Tetral-ethonium Compounds. By D. Edwards, J. J. Lewis, J. B. Stenlake and M. S. Zoha .. .. .. .. .. .. 122 T Some Aspects of the Property of Angle of R epose of Powders. By David Train .. .. .. .. .. .. .. .. 127 T The F low Properties of Powders U nder H umid Conditions. By D. J. Craik and B. F. Miller .. .. .. .. .. .. 136 T Observations on Increased D isintegration Times of Tablets on Storage. By R. A. Ramsay .. .. .. .. .. .. 145 T The Preparation and the Antibacterial and Antifungal Pro­ perties of Some Substituted Benzyl Alcohols. By D. V. Carter, P. T. Charlton, A. H. Fenton, J. R. Housley and B. Lessel .. 149 T The Interaction of Chelating Agents with Bacteria. Part I. 8-Hydroxyquinoline (Oxine) and Staphylococcus aureus. By A. H. Beckett, A. A. Vahora and Ann E. Robinson ..........................160 T The Determination of Phenolic Compounds in Pharmaceutical Preparations U sing 4-Aminophenazone. By C. A. Johnson and R. A. Savidge .. .. .. .. .. .. .. .. 171 T Viscosity Studies With Phosphatide Sols. By I. L. Thomas and L. Saunders .. .. .. .. .. .. .. .. 182 T Vegetable Purgatives Containing Anthracene D erivatives. Part X. A New Active Glycoside of Senna. By J. W. Fairbairn, C. A. Friedmann and H. A. Ryan .. .. .. .. .. 186 T Anatomical Studies in the G enus D igitalis. P arti. The Anatomy of the Inflorescence of D. purpurea L. By P. S. Cowley and J. M. Rowson .. .. .. .. .. .... 193 T Factors Influencing Percutaneous Absorption. By D. H. O. Gemmell and J. C. Morrison .. .. .. .. .. .. 210 T The Actions of Digitalis Leaf Preparations and of Cardiac G lycosides on the Isolated Right Ventricle of the Guinea Pig. By G. A. Stewart .. .. .. .. .. .. .. 213 T Vegetable Purgatives Containing Anthracene D erivatives. Part IX. An Aloin-like Substance in Rhamnus purshiana DC. By J. W. Fairbairn and V. K. Mital .. .. .. 217 T The Isolation and Comparison of Pyrogenic Factors from Proteus vulgaris. By J. P. Todd, J. A. M. Shaw, J. A. Blain and W. B o y le .................................................................................................. 223 T The Surface Activities of a- and /3-(Acyl) Lysolecithins. By N. Robinson and L. Saunders .. .. .. .. .. .. 227 T A N ote on the Pharmacology of R escinnamine and Serpentine. By M. S. Zoha, S. M. Kirpekar and J. J. Lewis .. .. .. 231 T A Comparative Study of the H ydrolytic and Non-hydrolytic Methods for the Assay of Solanaceous Drugs. By R. E. A. Drey ..................................................................................................241 T Identification of Seeds F rom Various Species of Strophanthus. By W. G. Thomas and Colin Melville .. .. .. .. 247 T The F unctional G roupings of Cucurbitacin E (a-ELATERiN). By J. N. T. Gilbert and David W. Mathieson .. .. .. .. 252 T BRITISH PHARMACEUTICAL CONFERENCE NINETY-FIFTH ANNUAL MEETING, LLANDUDNO, 1958 REPORT OF PROCEEDINGS OFFICERS: President: D. W. H u d s o n , M.P.S. Chairman: G. E. F o s t e r , B.Sc., Ph.D., F.R.I.C., Dartford Vice-Chairmen: R. R. B e n n e t t , B.Sc., F.P.S., F.R.I.C., Eastbourne. H a r o l d D e a n e , B.Sc., F.P.S., F.R.I.C., Sudbury. H. H u m p h r e y s J o n e s , F.P.S., F.R.I.C., Liverpool. T. E. W a l l is , D.Sc., F.P.S., F.R.I.C., F.L.S., London. H. B r in d l e , M.Sc., F.P.S., F.R.I.C., Manchester. B. A. B u l l , F.P.S., A.R.I.C., Nottingham. N o r m a n E v e r s , Ph.D., F.R.I.C., Ware. A. D. P o w e l l , M.P.S., F.R.I.C., Nottingham. H. B e r r y , B.Sc., Dip.Bact. (London), F.P.S., F.R.I.C., Eastbourne. H. B. M a c k ie , B.Pharm., F.P.S., Brighton. G. R. B o y e s , L.M.S.S.A., B.Sc., F.P.S., F.R.I.C., London. H. D a v is , C.B.E., B.Sc., Ph.D., F.P.S., F.R.I.C., London. J. P. T o d d ., Ph.D., F.P.S., F.R.I.C., Glasgow. K. B u l l o c k , M.Sc., Ph.D., F.P.S., F.R.I.C., Manchester. F r a n k H a r t l e y , B.Sc., Ph.D., F.P.S., F.R.I.C., London. Honorary Treasurer: H. T r e v e s B r o w n , B .S c ., F.P.S., London. Honorary General Secretaries: H. G. R o l f e , B.Sc., F.P.S., F.R.I.C., London. E. F. H e r s a n t , B.Pharm., Ph.D., F.P.S., F.R.I.C., London. Other Members of the Executive Committee: The C h a ir m a n o f the Executive of the Scottish Department o f the Pharmaceutical Society of Great Britain (ex officio). The P r e s id e n t of the Pharmaceutical Society of Ireland (ex officio). The P r e s id e n t of the Pharmaceutical Society of Northern Ireland (ex officio). The E d it o r of the Journal of Pharmacy and Pharmacology (ex officio). The C h a ir m a n and Honorary Secretary of the Local Committee (ex officio). D. C. A d a m s o n , F.R.I.C., Greenford. J. W. F a ir b a ir n , B.Sc., Ph.D., F.P.S., *E. A . B rocklehurst , M.P.S., J.P., F.R.I.C., F.L.S., London. Hull. W. H. L i n n e l l , D.Sc., Ph.D., F.P.S., A. W. Bull, B.Sc., B.Pharm., F.P.S., F.R.I.C., London. F.R.I.C., Nottingham. *G. H. H u g h e s , M.P.S., Colwyn Bay. K. R. C a p p e r , B.Pharm., Ph.D., J. B. L l o y d , M.P.S., Manchester. F.P.S., D.I.C., London. *H. S t e in m a n , M.P.S., Manchester. * Members nominated by the Council of the Pharmaceutical Society of Great Britain. 1 T A REPORT OF PROCEEDINGS PROCEEDINGS OF CONFERENCE LLANDUDNO, 1958 THE OPENING SESSION The opening session of the Conference was held in the Pier Pavilion in Llandudno, on Monday, September 15, with Mr. D. W. Hudson, President of the Conference (President of the Pharmaceutical Society) in the Chair. On the platform were the Chairman of the Conference (Dr. G. E. Foster), the Chairman of Llandudno Urban District Council (Councillor H. Neville, Chairman of the Local Committee), the Vice-Chairman and Secretary of the Local Committee (Mr. E. Fearnhead and Mr. M. H. Thomas), the Honorary General Secretaries together with members of the Conference Executive Committee.
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