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Effectiveness of Fertility Awareness–Based Methods for Pregnancy

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Contraception: Review Effectiveness of Fertility Awareness–Based Methods for Pregnancy Prevention A Systematic Review 08/17/2018 on BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3fPTF9rH0T9Ib7mROJHcu9aWeY+7gZmEZhp/vmUkacL6PNyx7vdpuQQ== by https://journals.lww.com/greenjournal from Downloaded Downloaded Rachel Peragallo Urrutia, MD, MS, Chelsea B. Polis, PhD, Elizabeth T. Jensen, PhD, Margaret E. Greene, PhD, Emily Kennedy, MA, and Joseph B. Stanford, MD, MSPH from https://journals.lww.com/greenjournal OBJECTIVE: To summarize best available prospective varied widely: 11.2–14.1 for the Standard Days Method, data on typical and perfect use effectiveness of fertility 13.7 for the TwoDay Method, 10.5–33.6 for the Billings awareness–based methods for avoiding pregnancy. Ovulation Method, 4–18.5 for the Marquette Mucus-only DATA SOURCES: We conducted a systematic review of Method, 9.0–9.8 for basal body temperature methods, by studies published in English, Spanish, French, or German 13.2 for single-check symptothermal methods, 11.2– BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3fPTF9rH0T9Ib7mROJHcu9aWeY+7gZmEZhp/vmUkacL6PNyx7vdpuQQ== by June 2017 in MEDLINE, EMBASE, CINAHL, Web of 33.0 for Thyma double-check symptothermal methods, Science, and ClinicalTrials.gov. 1.8 for Sensiplan, 25.6 for Persona, 2–6.8 for the Mar- METHODS OF STUDY SELECTION: We reviewed 8,755 quette Monitor-only Method, and 6–7 for the Marquette unique citations and included 53 studies that contained Monitor and Mucus Method. First-year perfect use preg- 50 or greater women using a specific fertility awareness– nancy rates or probabilities among moderate-quality based method to avoid pregnancy, calculated life table studies were 4.8 for the Standard Days Method, 3.5 for pregnancy probabilities or Pearl rates, and prospectively the TwoDay Method, 1.1–3.4 for the Billings Ovulation measured pregnancy intentions and outcomes. We sys- Method, 2.7 for the Marquette Mucus Method, 0.4 for tematically evaluated study quality. Sensiplan, 12.1 for Persona, and 0 for the Marquette TABULATION, INTEGRATION, AND RESULTS: Of 53 Monitor. included studies, we ranked 0 high quality, 21 moderate CONCLUSION: Studies on the effectiveness of each quality, and 32 low quality for our question of interest. fertility awareness–based method are few and of low to Among moderate-quality studies, first-year typical use moderate quality. Pregnancy rates or probabilities pregnancy rates or probabilities per 100 woman-years varied widely across different fertility awareness–based auspices of the Guttmacher Institute. The views expressed herein are those of the From the Department of Obstetrics and Gynecology, University of North authors and do not necessarily reflect the views of the Guttmacher Institute. Carolina, Chapel Hill, North Carolina; Reply OB/Gyn & Fertility, Cary, North Carolina; the Department of Epidemiology, Johns Hopkins Bloomberg School of The authors thank Ammu Vijay and Nancy DeMaria for their help during the Public Health, Baltimore, Maryland; the Guttmacher Institute, New York, New abstract and full-text screening portions of the study; Jennifer Walker, MLS, for York; the Department of Epidemiology and Prevention, Wake Forest University her assistance with developing and conducting the literature search; and Eugene School of Medicine, Winston-Salem, North Carolina; GreeneWorks, Washing- Urrutia, PhD, for his help with preparation of Figures 2 and 3. ton, DC; and the Department of Family and Preventive Medicine, University of Each author has indicated that he or she has met the journal’s requirements for Utah, Salt Lake City, Utah. authorship. Funding for the review was provided through a USAID contract. KNDR Health- Received March 27, 2018. Received in revised form May 10, 2018. Accepted May care, LLC provided in-kind donation (EK effort). KNDR had no role in the 24, 2018. on design of the project or review of the data or manuscript. USAID provided 08/17/2018 funding starting after the design of the project, the literature search, the abstract Corresponding author: Rachel Peragallo Urrutia, MD, MS, Department of review, and the full-text review. They had no role in design of the project or data Obstetrics and Gynecology, University of North Carolina, CB#7570, Chapel analysis plan. USAID read the manuscript before publication and provided com- Hill, NC 27599-7570; email: [email protected]. ments that the authors were not obligated to incorporate. Financial Disclosure Presented at the North American Forum on Family Planning, October 14–16, Dr. Peragallo Urrutia’s salary to the University of North Carolina is paid in part 2017, Atlanta, Georgia; the National Title X Reproductive Health Conference, by KNDR Healthcare, LLC, for her work at Reply Ob/Gyn & Fertility. KNDR’s July 15–18, 2018, Kansas City, Missouri; and the Annual Scientific Assembly mission is to promote fertility awareness–based methods of family planning. The Meeting of the International Institute of Restorative Reproductive Medicine, July other authors did not report any potential conflicts of interest. 25, 2018, Ontario, California. © 2018 by the American College of Obstetricians and Gynecologists. Published Chelsea B. Polis is affiliated with the Guttmacher Institute. Her affiliation is by Wolters Kluwer Health, Inc. All rights reserved. included for informational purposes only; this work was not conducted under the ISSN: 0029-7844/18 VOL. 00, NO. 00, MONTH 2018 OBSTETRICS & GYNECOLOGY 1 Ó 2018 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. methods (and in some cases, within method types), even 2017. We used Covidence available at www.covi- after excluding low-quality studies. Variability across dence.org for title–abstract and full-text screening. populations studied precludes comparisons across meth- ods. STUDY SELECTION (Obstet Gynecol 2018;00:1–14) We assembled a multidisciplinary team, including DOI: 10.1097/AOG.0000000000002784 experts in clinical reproductive health care (R.P.U. and J.B.S.), epidemiology (C.B.P. and E.T.J.), demog- – F ertility awareness based methods of family plan- raphy (M.E.G.), fertility awareness–based method ning help users identify the days of the menstrual instruction (R.P.U. and E.K.), systematic reviews cycle when intercourse is most likely to result in (C.B.P. and R.P.U.), and conduct of fertility 1–3 pregnancy. Users track changes in one or more awareness–based method effectiveness studies (J.B.S.). biomarkers (menstrual dates, basal body temperature, We included studies that prospectively collected cervical mucus or position, and urinary hormone information on pregnancy intentions and outcomes metabolites) to estimate days of highest fecundity (the and which followed at least 50 participants using fertile window) (Table 1). People who want to avoid a specific fertility awareness–based method to avoid pregnancy can avoid intercourse or use additional pregnancy. Fertility awareness–based methods were family planning methods (eg, barriers) during their defined as any method using specific rules to fertile window. approximate the fertile window based on tracking one Users of any method of pregnancy prevention or more of the following biomarkers: menstrual dates, need reliable evidence on perfect and typical use basal body temperature, cervical mucus, cervical effectiveness to support informed choice. Different position or consistency, or urinary hormones. study designs for effectiveness estimation have differ- Appendix 2, available online at http://links.lww.com/ ent advantages and disadvantages. Because partici- AOG/B132, provides more detailed study inclusion pants in prospective studies may be highly selected criteria. and less representative of typical users than partic- Trained investigator dyads independently ipants in population-based surveys, estimates from screened titles and abstracts for inclusion and then “ ”4 clinical studies likely represent best-case scenarios. screened relevant full-text articles. We reconciled Retrospective surveys depend on patients accurately conflicts through discussion. We included studies that recalling details about reproductive behavior over did not calculate a pregnancy rate if enough data were several years and cannot be used to calculate perfect provided for the review team to calculate a 12-month use estimates. Importantly, low use of fertility or 13-cycle Pearl rate.7 – awareness based methods has necessitated lumping Starting with the key questions outlined in our – users of disparate fertility awareness based methods protocol, we drafted an abstraction form and each together to calculate an overall typical use estimate in investigator piloted the form on several studies. We 5,6 retrospective surveys. However, this may obscure met in person to discuss and finalize the form (Appendix the effectiveness of individual methods. We con- 3, available online at http://links.lww.com/AOG/B132). ducted a comprehensive search to identify prospective Investigator dyads independently extracted data for studies estimating typical and perfect use effectiveness included studies in the Systematic Review Data Repos- – of individual fertility awareness based methods and itory (https://srdr.ahrq.gov). We extracted data on study systematically evaluated their quality. design, exclusion and inclusion criteria, sample size, demographics, type of fertility awareness–based SOURCES method, attrition,
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