Transcription of a Protein-Coding Gene on B Chromosomes of the Siberian
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Fitzhenry Yields 2016.Pdf
Stellenbosch University https://scholar.sun.ac.za ii DECLARATION By submitting this dissertation electronically, I declare that the entirety of the work contained therein is my own, original work, that I am the sole author thereof (save to the extent explicitly otherwise stated), that reproduction and publication thereof by Stellenbosch University will not infringe any third party rights and that I have not previously in its entirety or in part submitted it for obtaining any qualification. Date: March 2016 Copyright © 2016 Stellenbosch University All rights reserved Stellenbosch University https://scholar.sun.ac.za iii GENERAL ABSTRACT Fallow deer (Dama dama), although not native to South Africa, are abundant in the country and could contribute to domestic food security and economic stability. Nonetheless, this wild ungulate remains overlooked as a protein source and no information exists on their production potential and meat quality in South Africa. The aim of this study was thus to determine the carcass characteristics, meat- and offal-yields, and the physical- and chemical-meat quality attributes of wild fallow deer harvested in South Africa. Gender was considered as a main effect when determining carcass characteristics and yields, while both gender and muscle were considered as main effects in the determination of physical and chemical meat quality attributes. Live weights, warm carcass weights and cold carcass weights were higher (p < 0.05) in male fallow deer (47.4 kg, 29.6 kg, 29.2 kg, respectively) compared with females (41.9 kg, 25.2 kg, 24.7 kg, respectively), as well as in pregnant females (47.5 kg, 28.7 kg, 28.2 kg, respectively) compared with non- pregnant females (32.5 kg, 19.7 kg, 19.3 kg, respectively). -
Plenary and Platform Abstracts
American Society of Human Genetics 68th Annual Meeting PLENARY AND PLATFORM ABSTRACTS Abstract #'s Tuesday, October 16, 5:30-6:50 pm: 4. Featured Plenary Abstract Session I Hall C #1-#4 Wednesday, October 17, 9:00-10:00 am, Concurrent Platform Session A: 6. Variant Insights from Large Population Datasets Ballroom 20A #5-#8 7. GWAS in Combined Cancer Phenotypes Ballroom 20BC #9-#12 8. Genome-wide Epigenomics and Non-coding Variants Ballroom 20D #13-#16 9. Clonal Mosaicism in Cancer, Alzheimer's Disease, and Healthy Room 6A #17-#20 Tissue 10. Genetics of Behavioral Traits and Diseases Room 6B #21-#24 11. New Frontiers in Computational Genomics Room 6C #25-#28 12. Bone and Muscle: Identifying Causal Genes Room 6D #29-#32 13. Precision Medicine Initiatives: Outcomes and Lessons Learned Room 6E #33-#36 14. Environmental Exposures in Human Traits Room 6F #37-#40 Wednesday, October 17, 4:15-5:45 pm, Concurrent Platform Session B: 24. Variant Interpretation Practices and Resources Ballroom 20A #41-#46 25. Integrated Variant Analysis in Cancer Genomics Ballroom 20BC #47-#52 26. Gene Discovery and Functional Models of Neurological Disorders Ballroom 20D #53-#58 27. Whole Exome and Whole Genome Associations Room 6A #59-#64 28. Sequencing-based Diagnostics for Newborns and Infants Room 6B #65-#70 29. Omics Studies in Alzheimer's Disease Room 6C #71-#76 30. Cardiac, Valvular, and Vascular Disorders Room 6D #77-#82 31. Natural Selection and Human Phenotypes Room 6E #83-#88 32. Genetics of Cardiometabolic Traits Room 6F #89-#94 Wednesday, October 17, 6:00-7:00 pm, Concurrent Platform Session C: 33. -
Co-Occupancy by Multiple Cardiac Transcription Factors Identifies
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart Aibin Hea,b,1, Sek Won Konga,b,c,1, Qing Maa,b, and William T. Pua,b,2 aDepartment of Cardiology and cChildren’s Hospital Informatics Program, Children’s Hospital Boston, Boston, MA 02115; and bHarvard Stem Cell Institute, Harvard University, Cambridge, MA 02138 Edited by Eric N. Olson, University of Texas Southwestern, Dallas, TX, and approved February 23, 2011 (received for review November 12, 2010) Identification of genomic regions that control tissue-specific gene study of a handful of model genes (e.g., refs. 7–10), it has not been expression is currently problematic. ChIP and high-throughput se- evaluated using unbiased, genome-wide approaches. quencing (ChIP-seq) of enhancer-associated proteins such as p300 In this study, we used a modified ChIP-seq approach to define identifies some but not all enhancers active in a tissue. Here we genome wide the binding sites of these cardiac TFs (1). We show that co-occupancy of a chromatin region by multiple tran- provide unbiased support for collaborative TF interactions in scription factors (TFs) identifies a distinct set of enhancers. GATA- driving cardiac gene expression and use this principle to show that chromatin co-occupancy by multiple TFs identifies enhancers binding protein 4 (GATA4), NK2 transcription factor-related, lo- with cardiac activity in vivo. The majority of these multiple TF- cus 5 (NKX2-5), T-box 5 (TBX5), serum response factor (SRF), and “ binding loci (MTL) enhancers were distinct from p300-bound myocyte-enhancer factor 2A (MEF2A), here referred to as cardiac enhancers in location and functional properties. -
High Expression of an Unknown Long Noncoding RNA RP11-290L1.3 from GDM Macrosomia and Its Effect on Preadipocyte Differentiation
ID: 20-0584 10 2 Y Lin, Y Zhand, L Xu et al. RP11 enhanced preadipocyte 10:2 191–204 differentiation RESEARCH High expression of an unknown long noncoding RNA RP11-290L1.3 from GDM macrosomia and its effect on preadipocyte differentiation Yu Lin1,*, Yingying Zhang1,*, Lei Xu2,*, Wei Long1, Chunjian Shan1, Hongjuan Ding1, Lianghui You1, Chun Zhao1 and Zhonghua Shi1 1State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China 2Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China Correspondence should be addressed to C Zhao or Z Shi: [email protected] or [email protected] *(Y Lin, Y Zhang and L Xu contributed equally to this work) Abstract Aims: Gestational diabetes mellitus (GDM)-induced macrosomia is predominantly Key Words characterized by fat accumulation, which is closely related to adipocyte differentiation. f long noncoding RNA An unknown long noncoding RNA RP11-290L1.3, referred to as RP11, was identified to f GDM be dramatically upregulated in the umbilical cord blood of women with GDM-induced f preadipocyte macrosomia in our previous study. We conducted this study to identify the function of differentiation RP11 in GDM-induced macrosomia. f macrosomia Methods: The effects of RP11 gain- and loss-of-function on HPA-v (human preadipocytes- f fat accumulation visceral) adipogenesis were determined with lentivirus mediated cell transduction. The mRNA and protein expression levels of adipogenesis makers were evaluated by qPCR/Western blot. Then, we performed the microarray and pathway analysis to explore the possible mechanisms by which RP11 regulates adipogenesis. -
Comparison and Analysis on the Existing Single-Herbal Strategies Against Viral Myocarditis
Hindawi Genetics Research Volume 2021, Article ID 9952620, 12 pages https://doi.org/10.1155/2021/9952620 Research Article Comparison and Analysis on the Existing Single-Herbal Strategies against Viral Myocarditis Yu Cao ,1 Yang Liu,2 Tian Zhang,3 Jing Pan,4 Wei Lei,1 and Boli Zhang1 1Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 10 Poyanghu Road, Tianjin 301617, China 2School of Chemical Engineering and Technology, Tianjin University, No. 135 Yaguan Road, Tianjin 300350, China 3State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Neinan Street, Beijing 100700, China 4Department of Reproductive Medicine, Inner Mongolia Maternal and Child Health Care Hospital, No. 18 North Second Ring Express Road, Hohhot 010020, China Correspondence should be addressed to Yu Cao; [email protected] Received 27 March 2021; Accepted 31 July 2021; Published 9 August 2021 Academic Editor: Hafiz Ishfaq Ahmad Copyright © 2021 Yu Cao et al. ,is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. Herbal medicine is one of crucial symbols of Chinese national medicine. Investigation on molecular responses of different herbal strategies against viral myocarditis is immeasurably conducive to targeting drug development in the current international absence of miracle treatment. Methods. Literature retrieval platforms were applied in the collection of existing empirical evidences for viral myocarditis-related single-herbal strategies. SwissTargetPrediction, Metascape, and Discovery Studio coordinating with multidatabases investigated underlying target genes, interactive proteins, and docking molecules in turn. -
Supplementary Table S4. FGA Co-Expressed Gene List in LUAD
Supplementary Table S4. FGA co-expressed gene list in LUAD tumors Symbol R Locus Description FGG 0.919 4q28 fibrinogen gamma chain FGL1 0.635 8p22 fibrinogen-like 1 SLC7A2 0.536 8p22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 DUSP4 0.521 8p12-p11 dual specificity phosphatase 4 HAL 0.51 12q22-q24.1histidine ammonia-lyase PDE4D 0.499 5q12 phosphodiesterase 4D, cAMP-specific FURIN 0.497 15q26.1 furin (paired basic amino acid cleaving enzyme) CPS1 0.49 2q35 carbamoyl-phosphate synthase 1, mitochondrial TESC 0.478 12q24.22 tescalcin INHA 0.465 2q35 inhibin, alpha S100P 0.461 4p16 S100 calcium binding protein P VPS37A 0.447 8p22 vacuolar protein sorting 37 homolog A (S. cerevisiae) SLC16A14 0.447 2q36.3 solute carrier family 16, member 14 PPARGC1A 0.443 4p15.1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha SIK1 0.435 21q22.3 salt-inducible kinase 1 IRS2 0.434 13q34 insulin receptor substrate 2 RND1 0.433 12q12 Rho family GTPase 1 HGD 0.433 3q13.33 homogentisate 1,2-dioxygenase PTP4A1 0.432 6q12 protein tyrosine phosphatase type IVA, member 1 C8orf4 0.428 8p11.2 chromosome 8 open reading frame 4 DDC 0.427 7p12.2 dopa decarboxylase (aromatic L-amino acid decarboxylase) TACC2 0.427 10q26 transforming, acidic coiled-coil containing protein 2 MUC13 0.422 3q21.2 mucin 13, cell surface associated C5 0.412 9q33-q34 complement component 5 NR4A2 0.412 2q22-q23 nuclear receptor subfamily 4, group A, member 2 EYS 0.411 6q12 eyes shut homolog (Drosophila) GPX2 0.406 14q24.1 glutathione peroxidase -
TNNI3K Is a Novel Mediator of Myofilament Function and Phosphorylates Cardiac Troponin I
Brazilian Journal of Medical and Biological Research (2013) 46: 128-137, http://dx.doi.org/10.1590/1414-431X20122515 ISSN 1414-431X TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I Hui Wang*, Lin Wang*, Li Song, Yan-Wan Zhang, Jue Ye, Rui-Xia Xu, Na Shi and Xian-Min Meng Core Laboratory, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Abstract The phosphorylation of cardiac troponin I (cTnI) plays an important role in the contractile dysfunction associated with heart failure. Human cardiac troponin I-interacting kinase (TNNI3K) is a novel cardiac-specific functional kinase that can bind to cTnI in a yeast two-hybrid screen. The purpose of this study was to investigate whether TNNI3K can phosphorylate cTnI at specific sites and to examine whether the phosphorylation of cTnI caused by TNNI3K can regulate cardiac myofilament contractile function. Co-immunoprecipitation was performed to confirm that TNNI3K could interact with cTnI. Kinase assays further indicated that TNNI3K did not phosphorylate cTnI at Ser23/24 and Ser44, but directly phosphorylated Ser43 and Thr143 in vitro. The results obtained for adult rat cardiomyocytes also indicated that enhanced phosphorylation of cTnI at Ser43 and Thr143 correlated with rTNNI3K (rat TNNI3K) overexpression, and phosphorylation was reduced when rTNNI3K was knocked down. To determine the contractile function modulated by TNNI3K-mediated phosphorylation of cTnI, cardiomyocyte contraction was studied in adult rat ventricular myocytes. The contraction of cardiomyocytes increased with rTNNI3K overexpression and decreased with rTNNI3K knockdown. We conclude that TNNI3K may be a novel mediator of cTnI phosphorylation and contribute to the regulation of cardiac myofilament contraction function. -
Caribou (Barren-Ground Population) Rangifer Tarandus
COSEWIC Assessment and Status Report on the Caribou Rangifer tarandus Barren-ground population in Canada THREATENED 2016 COSEWIC status reports are working documents used in assigning the status of wildlife species suspected of being at risk. This report may be cited as follows: COSEWIC. 2016. COSEWIC assessment and status report on the Caribou Rangifer tarandus, Barren-ground population, in Canada. Committee on the Status of Endangered Wildlife in Canada. Ottawa. xiii + 123 pp. (http://www.registrelep-sararegistry.gc.ca/default.asp?lang=en&n=24F7211B-1). Production note: COSEWIC would like to acknowledge Anne Gunn, Kim Poole, and Don Russell for writing the status report on Caribou (Rangifer tarandus), Barren-ground population, in Canada, prepared under contract with Environment Canada. This report was overseen and edited by Justina Ray, Co-chair of the COSEWIC Terrestrial Mammals Specialist Subcommittee, with the support of the members of the Terrestrial Mammals Specialist Subcommittee. For additional copies contact: COSEWIC Secretariat c/o Canadian Wildlife Service Environment and Climate Change Canada Ottawa, ON K1A 0H3 Tel.: 819-938-4125 Fax: 819-938-3984 E-mail: [email protected] http://www.cosewic.gc.ca Également disponible en français sous le titre Ếvaluation et Rapport de situation du COSEPAC sur le Caribou (Rangifer tarandus), population de la toundra, au Canada. Cover illustration/photo: Caribou — Photo by A. Gunn. Her Majesty the Queen in Right of Canada, 2016. Catalogue No. CW69-14/746-2017E-PDF ISBN 978-0-660-07782-6 COSEWIC Assessment Summary Assessment Summary – November 2016 Common name Caribou - Barren-ground population Scientific name Rangifer tarandus Status Threatened Reason for designation Members of this population give birth on the open arctic tundra, and most subpopulations (herds) winter in vast subarctic forests. -
Whole Exome Sequencing in Families at High Risk for Hodgkin Lymphoma: Identification of a Predisposing Mutation in the KDR Gene
Hodgkin Lymphoma SUPPLEMENTARY APPENDIX Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene Melissa Rotunno, 1 Mary L. McMaster, 1 Joseph Boland, 2 Sara Bass, 2 Xijun Zhang, 2 Laurie Burdett, 2 Belynda Hicks, 2 Sarangan Ravichandran, 3 Brian T. Luke, 3 Meredith Yeager, 2 Laura Fontaine, 4 Paula L. Hyland, 1 Alisa M. Goldstein, 1 NCI DCEG Cancer Sequencing Working Group, NCI DCEG Cancer Genomics Research Laboratory, Stephen J. Chanock, 5 Neil E. Caporaso, 1 Margaret A. Tucker, 6 and Lynn R. Goldin 1 1Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD; 2Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD; 3Ad - vanced Biomedical Computing Center, Leidos Biomedical Research Inc.; Frederick National Laboratory for Cancer Research, Frederick, MD; 4Westat, Inc., Rockville MD; 5Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD; and 6Human Genetics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA ©2016 Ferrata Storti Foundation. This is an open-access paper. doi:10.3324/haematol.2015.135475 Received: August 19, 2015. Accepted: January 7, 2016. Pre-published: June 13, 2016. Correspondence: [email protected] Supplemental Author Information: NCI DCEG Cancer Sequencing Working Group: Mark H. Greene, Allan Hildesheim, Nan Hu, Maria Theresa Landi, Jennifer Loud, Phuong Mai, Lisa Mirabello, Lindsay Morton, Dilys Parry, Anand Pathak, Douglas R. Stewart, Philip R. Taylor, Geoffrey S. Tobias, Xiaohong R. Yang, Guoqin Yu NCI DCEG Cancer Genomics Research Laboratory: Salma Chowdhury, Michael Cullen, Casey Dagnall, Herbert Higson, Amy A. -
Gallina & Mandujano
Mongabay.com Open Access Journal - Tropical Conservation Science Vol. 2 (2):116-127, 2009 Special issue: introduction Research on ecology, conservation and management of wild ungulates in Mexico Sonia Gallina1 and Salvador Mandujano1 1 Departamento de Biodiversidad y Ecología Animal, Instituto de Ecología A. C., km. 2.5 Carret. Ant. Coatepec No. 351, Congregación del Haya, Xalapa 91070, Ver. México. E‐mail: <[email protected]>; <[email protected]> Abstract This special issue of Tropical Conservation Science provides a synopsis of nine of the eleven presentations on ungulates presented at the Symposium on Ecology and Conservation of Ungulates in Mexico during the Mexican Congress of Ecology held in November 2008 in Merida, Yucatan. Of the eleven species of wild ungulates in Mexico (Baird´s tapir Tapirus bairdii, pronghorn antelope Antilocapra americana, American bison Bison bison, bighorn sheep Ovis canadensis, elk Cervus canadensis, red brocket deer Mazama temama, Yucatan brown brocket Mazama pandora, mule deer Odocoileus hemionus, white-tailed deer Odocoileus virginianus, white-lipped peccary Tayassu pecari and collared peccary Pecari tajacu), studies which concern four of these species are presented: Baird’s tapir and the white lipped peccary, which are tropical species in danger of extinction; the bighorn sheep, of high value for hunting in the north-west; and the white-tailed deer, the most studied ungulate in Mexico due to its wide distribution in the country and high hunting and cultural value. In addition, two studies of exotic species, wild boar (Sus scrofa) and red deer (Cervus elaphus), are presented. Issues addressed in these studies are: population estimates, habitat use, evaluation of UMA (Spanish acronym for ‘Wildlife Conservation, Management and Sustainable Utilization Units’) and ANP (Spanish acronym for ‘Natural Protected Areas’) to sustain minimum viable populations, and the effect of alien species in protected areas and UMA, all of which allow an insight into ungulate conservation and management within the country. -
Sexual Selection and Extinction in Deer Saloume Bazyan
Sexual selection and extinction in deer Saloume Bazyan Degree project in biology, Master of science (2 years), 2013 Examensarbete i biologi 30 hp till masterexamen, 2013 Biology Education Centre and Ecology and Genetics, Uppsala University Supervisor: Jacob Höglund External opponent: Masahito Tsuboi Content Abstract..............................................................................................................................................II Introduction..........................................................................................................................................1 Sexual selection........................................................................................................................1 − Male-male competition...................................................................................................2 − Female choice.................................................................................................................2 − Sexual conflict.................................................................................................................3 Secondary sexual trait and mating system. .............................................................................3 Intensity of sexual selection......................................................................................................5 Goal and scope.....................................................................................................................................6 Methods................................................................................................................................................8 -
Phylogeny, Evolution, and Diversity of Old World Telemetacarpal Deer
Phylogeny, evolution, and diversity of Old World telemetacarpal deer (Capreolinae, Cervidae, Mammalia) Roman CROITOR (Chișinău/Aix‐en‐Provence) introduction • Modern telemetacarpal deer (subfamily Capreolinae) are represented by few very specialized Old World forms (1, Alces alces; 2, Rangifer tarandus; 3, Capreolus capreolus; 4, Hydropotes inermis) and a diversified radiationof New World telemetacarpal deer. The known paleontological record of Capreolinae in Eurasia is rather scarce and for some genera (Procapreolus) is traced from the Late Miocene, while other lineages appear only in the Early Pleistocene and already represented by very specialized forms (Alces). Some poor Pliocene remains of Capreolus and of a form similar to Alces are reported by Vislobokova et al. (1995) from the Late Pliocene of Baikal Area. Another interesting recent finding is Rangifer sp. from the Early Pleistocene of Western Siberia that maintains the primitive orientation of pedicles (Bondarev et al., 2017). Those sparse findings suggest that Capreolines continuously were present in the middle latitudes of Eurasia, but their fossil remains apparently are misunderstood. • The Miocene record of Capreolinae is insufficiently known and many of cervid forms and species are poorly understood. This is the case of Metadicrocerus variabilis, Cervavitus tarakliensis, and Pliocervus matheroni (traditionally are placed in the tribe Pliocervini of the subfamily Cervinae) that are believed to have the intermediate phylogenetic position between modern Cervinae (plesiometacarpal