bioRxiv preprint doi: https://doi.org/10.1101/712497; this version posted July 24, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. 1 The Genetic History of France 2 Aude Saint Pierre1*, Joanna Giemza2*, Matilde Karakachoff2, Isabel Alves2, Philippe 3 Amouyel3+, Jean-François Dartigues4+, Christophe Tzourio4+, Martial Monteil5, Pilar Galan6, 4 Serge Hercberg6, Richard Redon2, Emmanuelle Génin1*, Christian Dina2* 5 1Univ Brest, Inserm, EFS, CHU Brest, UMR 1078, GGB, F-29200 Brest, France 6 2l'institut du thorax, INSERM, CNRS, Univ Nantes, CHU Nantes, Nantes, France 7 3Univ. Lille, Inserm, CHU Lille University Hospital, Institut Pasteur de Lille, LabEx DISTALZ- 8 UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related, F-59000 9 Lille, France 10 4Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU 11 Bordeaux, F-33000 Bordeaux, France 12 5Université de Nantes, UMR 6566 CReAAH, LARA, Nantes, France 13 6Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de 14 Recherche en Epidémiologie et Statistiques, Inserm (U1153), Inra (U1125), Cnam, COMUE 15 Sorbonne Paris Cité, F-93017, Bobigny, France 16 * These authors contributed equally to this work 17 + On behalf of the 3C study 18 Running Title: The Genetic History of France 19 Key words: Population stratification, Genetic ancestry, Admixture, Demographic history, Gene 20 flow barriers, Association Study 21 Corresponding authors: Aude Saint Pierre,
[email protected] 22 Christian Dina,
[email protected] 23 1 bioRxiv preprint doi: https://doi.org/10.1101/712497; this version posted July 24, 2019.