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Stein Eye Institute

Annual Report 2013–2014

Annual Report 2013–2014Annual Report

TRANSFORMING EYE CARE

LOS ANGELES AND BEYOND

The Stein Eye Institute is a proud affiliate of the Doheny Eye Institute.

David Geffen School of Medicine at UCLA University of California, Los Angeles Stein Eye Institute Annual Report

July 1, 2013–June 30, 2014

Director Bartly J. Mondino, MD

Faculty Advisor Debora B. Farber, PhD, DPhhc

Managing Editor Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 Email: [email protected]

Editors Teresa Closson Ellen Haupt Rosalie Licht Peter J. López Debbie Sato M. Gail Summers

Guest Writer Dan Gordon

Photography Reed Hutchinson J. Charles Martin ASUCLA Photography

Design Robin Weisz/Graphic Design

Printing Colornet Press

Send questions, comments, and updates to: [email protected].

To view the Annual Report online, visit: jsei.org/annual_report.htm.

For more information about the Institute, see: www.jsei.org.

Stein Eye Institute 2 Transitions 4 Honors and Awards 5 Research 8 Education 10 Community Outreach 13 Philanthropy 15 Thank You 18 Jules and Doris Stein 25 Board of Trustees and Executive Committee 26

Faculty 29

Programs 81

Patient Care Services 82 Research and Treatment Centers 84 Clinical Laboratories 89 Training Programs 91

Appendices 95

Volunteer and Consulting Faculty 96 Residents and Fellows 98 Educational Offerings 99 Research Contracts and Grants 101 Clinical Research Studies 106 Publications of the Full-Time Faculty 112 Giving Opportunities 118 Dear Friends, In November 1966 the doors of the Jules Stein Eye Institute opened on the grounds of UCLA, and with dedication of purpose, the Institute has continued to grow in its commitment to further vision-science re search, ophthalmic education, and patient care. And last year, we celebrated the Stein Eye Institute’s transformation to a vision-science campus. Exciting changes continue. This 2013–2014 academic year, we proudly announced a long-term affiliation agreement with the Doheny Eye Institute, possibly making us the nation’s––if not the world’s––largest academic eye affiliation. Through this partnership, we are utilizing our collective strengths to develop innovative eye care therapies, to educate world leaders in ophthalmology and vision science, and to establish novel research that can lead to impactful discoveries. The clinical benefit of this affiliation was demonstrated in 2014, as patient access to eye care was expanded throughout the greater Los Angeles area and into the Orange County region, with Doheny Eye Center UCLA locations opening in Arcadia, Orange County, and Pasadena. Doheny physicians and scientists are now UCLA Department of Ophthalmology faculty members, and the Doheny ophthalmologists that patients and referring doctors know and trust, remain conveniently available––but now with the added backing of the UCLA Health System. We proudly stand on the shoulders of the ophthalmologists and vision- science researchers who came before us. Through their work, and our charge to preserve and restore vision, we are continually building upon this legacy of excellence. Now with the historic alliance of the Stein and Doheny Eye Institutes, we can have an even greater and positive impact on our community, nation, and beyond––extending our efforts to transform vision science and technology, nationally and internationally. I thank the exceptional donors and friends who share our dedication to the preservation of sight and the prevention of blindness and who contribute to our current and future accomplishments. Please enjoy our highlights of the 2013–2014 academic year. Sincerely,

Bartly J. Mondino, MD Bradley R. Straatsma, MD Endowed Chair in Ophthalmology Director, Stein Eye Institute Chairman, Department of Ophthalmology David Geffen School of Medicine at UCLA “Movements to advance science and medicine need the time, the effort, and the ability of those men and women who have learned to move the immovable mountain.”

Jules Stein, MD A Year in Review

July 1, 2013–June 30, 2014

his 2013–2014 academic year was highlighted by the signing of a historic affiliation agreement between UCLA’s Stein Eye Institute and the Doheny Eye Institute— extending our combined efforts in vision science and technology, nationally and internationally. This year saw Tpatients gaining greater access to the finest ophthalmologic care available, with the opening of three Doheny Eye Center UCLA locations. We have also welcomed new faculty and said goodbye to respected colleagues. Faculty members were recognized for their contributions to ophthalmology, and researchers made further inroads in vision-science investigations, increasing our knowledge of vision processes and eye diseases. Utilizing multidisciplinary, integrative education, faculty members mentored, counseled, lectured, and demonstrated new medical and scientific approaches to the next generation of ophthalmologists, further contributing to the preservation and restoration of vision around the world. And recognizing that private funding is critical to the advancement of science and medicine, generous donors provided needed support for the sight-saving endeavors of the Stein Eye Institute.

A Year in Review | Stein Eye Institute 1 Stein Eye Institute

Stein and Doheny Eye Institute Sign Historic Affiliation Agreement

UCLA’s Stein Eye Institute and the Doheny Eye Institute have signed a long-term affiliation agreement to create the nation’s preeminent centers for ophthalmic patient care, vision research, and education. Each organization is preserving its identity and mission, while combining clinical and teaching and operations. And patient access to eye care is already expanding throughout greater Los Angeles and into Orange County. Under the terms of the agreement, Doheny physicians and scientists are UCLA Department of Ophthalmology faculty members. The affiliation will utilize each organization’s strengths to establish novel research leading to impactful discoveries, to develop innovative eye care therapies, and to educate world leaders in ophthalmology and vision science. It also aligns strengths that have factored into world recognition for Stein Eye and Doheny––both organizations are consistently in the top-10 of the U.S. News & World Report Best Hospital Rankings for ophthalmology. The Stein Eye Institute’s vision science Prior to this affiliation, the Doheny Eye Institute had been associated with the campus at UCLA. University of Southern California. In early 2013, Doheny carefully considered pro- posals from distinguished universities and institutions across the country and selected UCLA’s Stein Eye Institute as its new academic partner. “By selecting UCLA and the Stein Eye Institute,” says Marissa Goldberg, Doheny chief operating officer, chief financial officer, and board member, “we gain complementary clinical, research, and educational strengths and the opportunity to better serve patients.”

“The Stein/Doheny partnership makes sense. We share identical missions. We have a long history of cordial, mutually beneficial relations. Our locations support convenient collaboration, and this is a great opportunity for research and discovery. And, perhaps most significantly, together we will have a synergistic effect.”

Bartly J. Mondino, MD, Chairman of the UCLA Department of Ophthalmology and Director, Stein Eye Institute

Broadening Patient Access to Eye Care

Demonstrative benefits from the historic alliance were felt almost immediately, with three Doheny Eye Center UCLA locations opening in Arcadia, Orange County, and Pasadena in 2014, broadening patient access to eye care across the greater Los Angeles region and into Orange County. The Doheny Eye Centers UCLA join the prestigious Stein Eye Institute in Westwood, the Stein Eye Center–Santa Monica, and the UCLA Department of Ophthalmology-affiliated teaching satellite hospitals: Veterans Affairs Greater Los Angeles Healthcare Center at West Los Angeles and Sepulveda, Harbor- UCLA Medical Center, and Olive View-UCLA Medical Center. “From the westside to the eastside and south to Orange County, patients throughout Los Angeles and neighboring regions now have access to the fin- The Huntington Pavilion is home to the est ophthalmologic care available,” says chairman of the UCLA Department of Doheny Eye Center UCLA–Pasadena. Ophthalmology and director of the Stein Eye Institute, Bartly J. Mondino, MD.

2 Stein Eye Institute | A Year in Review COUNTY Olive View-UCLA Medical Center SYLMAR

LOS ANGELES

Doheny Eye Center UCLA

VENTURA COUNTY PASADENA

Stein Eye Institute UCLA WESTWOOD Doheny Eye Center UCLA ARCADIA From the westside to the

Veteran's Affairs eastside and south to Stein Eye Center UCLA Healthcare Center SANTA MONICA WEST LOS ANGELES Orange County, patients

LOS ANGELES COUNTY throughout Los Angeles ORANGE COUNTY and neighboring regions

Harbor-UCLA Medical Center TORRANCE now have access to the finest ophthalmologic care available.

Doheny Eye Center UCLA ORANGE COUNTY

For patients and referring physicians, the board-certified Doheny ophthalmologists they know and trust remain accessible. Many Doheny Eye Institute researchers and clinicians are joining the faculty roster of the David Geffen School of Medicine at UCLA, uniting with Stein Eye Institute colleagues under a single, integrated UCLA Department of Ophthalmology. With the opening of the Doheny Eye Centers UCLA, patients can continue to see their Doheny ophthalmologist––in the same familiar neighborhood––but now with the added backing of the UCLA Health System, one of the premier pro viders of modern medicine to the Los Angeles area and the nation. And for referring physicians, the opening of the three Doheny Eye Center UCLA locations means that Doheny ophthalmologists remain a resource in the community, providing comprehensive and subspecialty eye care at a nearby locale. The Doheny Eye Center UCLA–Orange Like the Stein Eye Institute and its satellite centers, Doheny Eye Centers UCLA County at Orange Coast Memorial provide the finest in clinical care, diagnostic equipment, and treatment. Medical Center.

Stein Eye Center–Santa Monica Doubles in Size to Meet Patient Demand

The Stein Eye Center–Santa Monica, was established in 2011, and this year, the Center expanded its facilities, doubling in size to meet patient demand. It was apparent from the outset that patients welcomed world-renowned comprehensive and subspecialty eye care within their local community, explains the Center’s Medical Director Colin A. McCannel, MD, professor of clinical ophthalmology at the Stein Eye Institute. “Immediately upon opening, the Center was bursting at the seams, and it became clear that the practice was outgrowing the available area. Through a stroke of luck, space opened next door, and the Center easily and conveniently expanded its current footprint.” The Stein Eye Center–Santa Monica doubled the number of exam rooms––from The Stein Eye Center–Santa Monica is conveniently located on Wilshire six to 12––and added a third diagnostic laboratory. The expansion also allowed Boulevard, between 18th Street and the addition of a vital subspecialty––pediatric ophthalmology. “Monica R. Khitri, 19th Street. MD, is an excellent, highly trained pediatric ophthalmologist, and we are excited to welcome her to the Stein Eye family,” affirmsBartly J. Mondino, MD, direc- For location and contact information tor of the Stein Eye Institute. A second comprehensive ophthalmologist, Tania for the Doheny Eye Centers UCLA Onclinx, MD, who completed her fellowship in ophthalmology at the Stein Eye and the Stein Eye Center–Santa Institute, and a second optometrist, Melissa M. Willey, OD, round out the new Monica, please refer to the Programs staffing, broadening the number of patients who can now be served. section of this Annual Report.

A Year in Review | Stein Eye Institute 3 Transitions

In Remembrance

Ronald E. Smith, MD Vice Chairman, Doheny Eye Centers UCLA October 7, 1942–March 17, 2014

Ronald E. Smith, MD, a great leader and academician, was an accomplished clinician-scientist whose achievements are legion. His research and clinical expertise centered in external eye disease, cornea, and uveitis. Dr. Smith was a recipient of National Eye Institute grant support, served on Study Section, and authored more than 300 scientific publications. He was past president of the American Academy of Ophthalmology and served for more than 10 years on the Academy Board of Trustees. He was past chair and board member of the American Board of Ophthalmology and was a member of honorary societies, including the American Ophthalmological Society, Academia Ophthalmologica Internationalis, and the Johns Hopkins Society of Scholars. He received numerous awards, including the Light Award from the Braille Institute of America, the Gold Medal of the International Uveitis Study Group, the Dr. Ronald E. Smith Castroviejo Medal of the Cornea Society, and the Lifetime Achievement Award of the American Academy of Ophthalmology. Dr. Smith served as Chairman of the USC Keck School of Medicine Department “Ron and I worked of Ophthalmology from 1995 to 2013. He resigned from the USC faculty in closely together as the November 2013 and became medical director of the Doheny Eye Institute pre- affiliation between paratory to joining the UCLA faculty as vice chairman of the Doheny Eye Centers UCLA and Doheny UCLA. began to be envisioned and evolve. Ron was extremely generous New Faculty and supportive, and he Alapakkam P. (Sam) Sampath, PhD, was appointed associate professor-in- elicited the best in residence, effective October 1, 2013. Dr. Sampath was previously an associate professor at the Department of Physiology and Biophysics, Zilkha Neurogenetic everyone. With his Institute, and Department of Ophthalmology, Keck School of Medicine at the passing, ophthalmology University of Southern California. Dr. Sampath previously trained at UCLA as lost a wonderful friend a graduate student with Gordon L. Fain, PhD, which he then followed with a and colleague.” postdoctoral fellowship at Stanford University and a second fellowship at the University of Washington. Bartly J. Mondino, MD Chairman of the UCLA Department of Ophthalmology and Director of the Stein Eye Institute

Dr. Alapakkam Sampath

4 Stein Eye Institute | A Year in Review Honors and Awards

Faculty Honors ffAnthony J. Aldave, MD, Walton Li Chair in Cornea and Uveitis, was awarded the gold medal for contributions to the field of ophthalmology by the Intraocular Implant and Refractive Society on September 8, 2013, in New Delhi, India. On September 19, 2013, Dr. Aldave delivered the Roger F. Meyer, MD, Lectureship in Cornea at the University of Michigan in Ann Arbor, Michigan. ffAnthony C. Arnold, MD, Jerome and Joan Snyder Chair in Ophthalmology, received the North American Neuro-Ophthalmology Society’s (NANOS) Distinguished Service Award, which was presented on March 5, 2014, at the NANOS Annual Meeting in San Juan, Puerto Rico. Dr. Arnold was also inducted into the American Ophthalmological Society on May 15, 2014, in New York, New York. ffJoseph Caprioli, MD, David May II Endowed Chair in Ophthalmology, presented the Irvine Lecture, “Rates of Functional Damage from Glaucoma,” on June 21, 2014, at the Doheny Eye Institute in Los Angeles, California. ffJoseph L. Demer, MD, PhD, Leonard Apt Endowed Chair in Pediatric Ophthalmology, presented the 14th Annual Richard G. Weaver Lecture on June 6, 2014, at Wake Forest University in Winston-Salem, North Carolina. ffGordon L. Fain, PhD, Distinguished Professor of the Departments of Integrative Biology/Physiology and of Ophthalmology, was elected as a Fellow of the American Academy for the Advancement of Science on November 25, 2013, and elected as an Overseas Fellow of Churchill College Cambridge, April 2014–August 2014. ffLynn K. Gordon, MD, PhD, Vernon O. Underwood Family Chair in Ophthal mology, received the David Geffen School of Medicine Excellence in Education Award on May 20, 2014, at UCLA, for leadership and commitment to ophthalmology education. ffGary N. Holland, MD, Jack H. Skirball Chair in Ocular Inflammatory Diseases, was named a Gold Fellow by the Association for Research in Vision and Ophthalmology (ARVO), May 2014. ffWayne L. Hubbell, PhD, Jules Stein Chair in Ophthalmology, was selected as a 2014 Fellow of the International EPR (ESR) Society in recognition of his influential and distinguished contributions to the practice of electron paramagnetic resonance (EPR)/electron spin resonance (ESR) spectroscopy and its welfare over a long period. ffSherwin J. Isenberg, MD, Laraine and David Gerber Chair in Ophthalmology, delivered the Presidential Lecture, Combatting Pediatric Blindness in the 21st Century, at the All India Ophthalmological Conference on February 6, 2014, in Agra, India. ffBartly J. Mondino, MD, director of the Stein Eye Institute and Bradley R. Straatsma, MD Endowed Chair in Ophthalmology, presented the Doheny Lecture, “Corneal Ulcers,” on June 20, 2014, at the Doheny Eye Institute in Los Angeles, California. ffSteven D. Schwartz, MD, holder of The Ahmanson Chair in Ophthalmology, was a featured specialist on The Charlie Rose Show series on the brain that aired April 22, 2014. In the public television episode devoted to blindness, Dr. Schwartz discussed current investigations in the use of stem cells for visual restoration.

A Year in Review | Stein Eye Institute 5 Dr. Bartly J. Mondino Recognized for Leadership in Academic Ophthalmology

As Chairman of the UCLA Department of Ophthalmology and Director of the Stein Eye Institute, Bartly J. Mondino, MD, is responsible for leading the academic pursuits of the Institute’s faculty and trainees, while maintaining the highest standards in research, teaching, and patient care. Dr. Mondino also holds active leadership roles outside of the Institute, setting a critical agenda for the advancement of ophthalmology and the prevention of blindness. In recognition of this work, the Association of University Professors of Ophthalmology (AUPO) recently lauded Dr. Mondino for ten years of service as AUPO executive vice president.

AUPO President Steven E. Feldon, MD, MBA, asked attendees to thank Dr. Mondino for all he had done on behalf of the AUPO, noting, “This is Bart’s last year as executive vice president, and all of us at AUPO owe him a special debt of gratitude for his leadership, devotion, grace, and good humor. He has taken our organization to a new level of performance and relevance.”

In his remarks, Dr. Mondino noted, “In this fast-changing and challenging health care environment, remaining both resilient and forward moving in academic ophthalmology is a daily challenge. In my work with outside organizations, I am privileged to be directly involved in creating policies that will serve and benefit the future of ophthalmology.”

AUPO Board of Trustees (left to right): Drs. Eduardo C. Alfonso (Chair, Department of Ophthalmology, University of Miami, Bascom Palmer Eye Institute), Oscar A. Cruz (Chair, Department of Ophthalmology, St. Louis University, St. Louis University Eye Institute), Bartly J. Mondino (Chair, Department of Ophthalmology, UCLA, Stein Eye Institute), Steven E. Feldon (Chair, Department of Ophthalmology, University of Rochester, Flaum Eye Institute), Russell Van Gelder (Chair, Department of Ophthalmology, University of Washington), and Randall J. Olson (Chair, Department of Ophthalmology, University of Utah, John A. Moran Eye Center). Not pictured: Drs. Julia A. Haller (Chair, Department of Ophthalmology, Thomas Jefferson University, Wills Eye Institute) and Keith D. Carter (Chair, Department of Ophthalmology, University of Iowa).

6 Stein Eye Institute | A Year in Review Dr. Bradley R. Straatsma Honored for Advancing Ophthalmology

At the April 2, 2014, Opening Ceremony of the World Ophthalmology Congress® in Tokyo, Japan, the Academia Ophthalmologica Internationalis (AIS) presented Bradley R. Straatsma, MD, JD, with the Bernardo Streiff Gold Medal. The medal is awarded every four years to an ophthalmologist who has contributed most to the advancement of ophthalmology through history, ethics, and education. Dr. Straatsma has, for more than 50 years, contributed to the advancement of ophthalmology around the world. Founding Director of the Stein Eye Institute and Founding Chairman of the UCLA Department of Ophthalmology, Dr. Straatsma has served as president of many major ophthalmological organizations, including the American Academy of Ophthalmology (AAO), the Pan American Association of Ophthalmology, the AIS, and the Foundation of the International Council of Ophthalmology (ICO). His commitment to ophthalmic education worldwide is seen through many of the major activities undertaken by the organizations he has led. His training of ophthalmology residents and fellows, his editorship of the American Journal of Ophthalmology, his critical support leading to the creation of an international curriculum, his publications on ophthalmic education, and the Dr. Bradley R. Straatsma establishment of the Straatsma Award to increase the quality of residency program leadership in the United States, are but a few examples of the major impact Dr. Straatsma has had globally on ophthalmic education. Dr. Straatsma has received worldwide acclaim for his tireless work on behalf of ophthalmology. Recognition includes the Howe Medal of the American Ophthalmological Society, the Jules François Golden Medal from the ICO, an Honorary Doctor of Sciences degree from Columbia University, and the Laureate Award from the AAO.

Institute Honors

Stein Eye Institute Rated Best in the West The Stein Eye Institute continued in its position as one of the top five American eye care centers—and the best in the Western United States for the 24th con- secutive year—according to U.S. News & World Report’s 2013–2014 Best Hospitals rankings. Additionally, Ronald Reagan UCLA Medical Center is the only hospital in Los Angeles and the Southern California region that appears on the magazine’s “Honor Roll,” a place reserved for medical centers with high levels of expertise in multiple specialties. The Ronald Reagan UCLA Medical Center was ranked the number one hospital in California.

Edie & Lew Wasserman Building Wins the Gold! The Edie & Lew Wasserman (ELW) Building has been officially awarded LEED Gold certification for the core and shell portion of the project. LEED, which represents Leadership in Energy and Environment Design, is an internationally recognized green building certification system that was developed by the U.S. Green Building Council in March 2000. The achievement of receiving gold certification is truly a testament to the team collaboration and integrated approach to the design and construction of the ELW Building. LEED provides a framework for identifying and implementing practical and measurable green building design, construction, operations, and maintenance solutions. LEED Gold is the third award the ELW Building has received.

A Year in Review | Stein Eye Institute 7 Research

Research is a key pillar of the Institute’s mission and a high priority for faculty who often devote their life’s work to furthering our knowledge of specific vision processes and eye diseases. In this academic year, Stein Eye researchers have made important discoveries and have continued to take leadership roles in defining how diseases are managed.

New Approach Improves Ability to Predict Which Glaucoma Patients Need Aggressive Treatment

One of the major challenges in the field of glaucoma has been reliably separating the patients who will progress rapidly—and thus need immediate and aggressive treatment—from those that will have a slow progression and may never lose vision. “We overtreat some patients and undertreat others,” says Joseph Caprioli, MD, David May II Endowed Chair in Ophthalmology, and chief of the Stein Eye Institute’s Glaucoma Division. “This is not a reflection of our compe- tence, but of our limitations in identifying which patients are most likely to lose vision and how quickly.” The problem with conventional approaches to predicting glaucoma progression, Dr. Caprioli says, is that they take the entire visual field into account—but, particularly in its early stages, glaucoma tends to inflict localized damage. “The nature of glaucoma damage is non-uniform progression,” Dr. Caprioli explains. “When you take global measures, looking at the average of all visual fields, you miss out on the regional change. The portion of the visual field that is affected is likely to decline at a faster rate than parts of the field that have been relatively spared. Dr. Caprioli and colleagues have developed a software-based approach designed to take these factors into account. The system analyzes a sequence of visual fields, pinpoints the areas that are progressing the most rapidly, and then uses the data to predict future visual field outcomes if there is no change in treatment––enabling identification of patients who are at the greatest risk of losing vision. Dr. Caprioli says his system quantifies what experienced glaucoma specialists have intuitively done in clinical exams. “You try to look for an area that might be getting worse and filter out the other measurements. But for a practitioner who does not do this every day, that qualitative process is much more difficult. The system provides them with a tool that is like having an ‘expert in a box.’” Dr. Caprioli’s group has conducted multiple studies to validate the system’s ability to separate patients who will progress rapidly from those who will progress slowly. The first study, focusing on patients with substantial visual field damage, found that forecasts correlated well with measured outcomes over six or more years of follow-up. The second study involved patients with much less glaucoma damage and found the new system to be equally adept at identifying earlier-stage patients at high risk of rapid progression. “We want to treat patients at the greatest risk of losing vision and spare patients who are likely to live out their lives with perfectly good vision. Knowing the rate of progression, we can make a better judgment about how aggressively that patient should be treated, if at all,” notes Dr. Caprioli.

Joseph Caprioli, MD

8 Stein Eye Institute | A Year in Review

1-SteinEyeAnnRpt-Highlights_Final.indd 8 11/13/14 5:55 PM “Discovery consists of seeing what everybody has seen and thinking what nobody has thought.”

Albert Szent-Györgyi, Hungarian Physiologist

Light-Adjustable Lens Technology a Potential “Game Changer” for Cataract Patients

The Stein Eye Institute is participating in a national Phase 3 clinical trial of the Calhoun Vision Light-Adjustable Lens (LAL), the final test before the lens is approved for the U.S. market. The clinical trial, headed by Kevin M. Miller, MD, Kolokotrones Chair in Ophthalmology, and chief of the Stein Eye Institute’s Comprehensive Ophthalmology Division, promises to dramatically improve un- aided visual acuity after cataract surgery. An estimated 3 million cataract operations are done each year—a number that is expected to increase significantly as the U.S. population ages. For the many patients who end up with significant refractive errors following surgery, the only options for seeing clearly have been eyeglasses, contact lenses, or pursuing refractive surgery. Moreover, it has not been possible for cataract surgeons to predict which patients will be left with refractive errors. Preliminary data indicate that on average, however, patients with LAL implants are experiencing better than 20/20 uncorrected vision. “That just doesn’t happen in other cataract trials,” Dr. Miller notes. “With the LAL, we wait until the eye is completely healed and then we adjust the lens. It means we just have to be close, not perfect, in the original procedure. This is a complete game-changer.” The unique chemistry of the LAL material enables ophthal- Dr. Kevin Miller performs a lock-in treatment on a light adjustable lens. mologists to adjust the power of the implanted lens after the surgery through the noninvasive application of light before “locking in” the changes. “This technology will enable cataract patients to have the types of refractive outcomes previously experienced only by patients who have LASIK,” says Dr. Miller. “The odds of achieving 20/20 or better uncorrected visual acuity after cataract surgery will go up dramatically. That’s very exciting.” After the LAL lens is implanted, if the power turns out to be slightly off kilter— preventing the patient from experiencing 20/20 uncorrected vision—the cataract surgeon can irradiate the lens with a precise pattern of UV light. (The back of the lens has a UV filter, preventing the ultraviolet light from reaching and potentially damaging the retina.) This can be done multiple times, if necessary, until the power is optimal, before the lens is locked into its final form. Patients The appearance of the treatment is are instructed to wear special eyeglasses that block ambient UV rays until the shown on a computer monitor. adjustments and lock-ins are completed. Dr. Miller points out that the technology promises to only improve with time. While the current lens is monofocal, the next step after FDA approval would be to add multifocality to the platform. Future generations of the technology, currently in the research pipeline, may allow for continuous adjustment, ensuring that patients can remain eyeglass-free for the rest of their lives. “The potential for the light-adjustable lens is enormous,” says Dr. Miller. “There are incremental technologies and there are disruptive technologies. This is disruptive—it has the ability to change everything.”

A Year in Review | Stein Eye Institute 9 Education

Education at the Stein Eye Institute is multifaceted––ranging from teaching medical students, residents, and fellows––to leading national conferences. In the course of their educational duties, faculty members mentor, counsel, lecture, and demonstrate. They are responsible for hundreds of clinical and scientific publications each year and are entrusted with developing and sharing new approaches to science and medicine that will ultimately result in improved patient care.

Annual Clinical and Research Seminar

Ophthalmologists gathered at the Stein Eye Institute on June 13, 2014, for the Institute’s most prestigious annual academic event, the Clinical and Research Seminar. Sponsored by the UCLA Department of Ophthalmology Association, the Seminar provides an opportunity for discussion of emerging vision research and celebrates teaching and faculty volunteerism.

At this year’s Seminar, Steven E. Feldon, MD, MBA, director of the Flaum Eye Institute and chairman of the Department of Ophthalmology at the University of Rochester in Rochester, New York, presented the 45th Jules Stein Lecture; Lois Senior Honor Award recipients E. H. Smith, MD, PhD, professor of ophthalmology at Harvard Medical School (L to R) Drs. Peter J. Cornell, Kathryn M. and clinician/scientist at Children’s Hospital in Boston, Massachusetts, gave the Gardner, and Yadavinder P. Dang. 12th Bradley R. Straatsma Lecture; and Amani A. Fawzi, MD, associate professor of ophthalmology at Northwestern University in Chicago, Illinois, delivered the 12th Thomas H. Pettit Lecture. In recognition of their service, selected volunteer and clinical faculty received awards of distinction. The Faculty Teaching Award, honoring contributions to residency education, was presented to Clinical Instructor in Ophthalmology Laura Bonelli, MD. Senior Honor Awards were presented to Peter J. Cornell, MD, Yadavinder P. Dang, MD, and Kathryn M. Gardner, MD, distinguished volunteer faculty who have been members of the UCLA Department of Ophthalmology for at least 25 years.

Comprehensive Ophthalmology Review Course

The Stein Eye Institute and the Doheny Eye Institute teamed up to sponsor the ninth Comprehensive Ophthalmology Review course on February 20–23, 2014. Dr. Amani A. Fawzi, (left) presented the The course co-directors, Sherwin Isenberg, MD, Laraine and David Gerber Pettit Lecture, Dr. Steven E. Feldon gave the Jules Stein Lecture, and Dr. Lois E. Chair in Ophthalmology at the Stein Eye Institute, and John Irvine, MD, medical H. Smith (right) presented the Straatsma director of the Doheny Eye Centers UCLA, organized a program concentrating Lecture. on the epidemiology, clinical presentation, diagnosis, and management of ophthalmological disease.

“There is a single light of science, and to brighten it anywhere is to brighten it everywhere.”

Isaac Asimov, American Author and Professor of Biochemistry

10 Stein Eye Institute | A Year in Review Attendees at the 2013 Vision Science Conference. 19th Annual Vision Science Conference

The 19th annual Vision Science Conference, co-sponsored by the National Institutes of Health/National Eye Institute Vision Science Training Grant and the Stein Eye Institute, was held October 24–26, 2013. More than 80 basic scientists and clinical researchers gathered at UCLA’s Lake Arrowhead Conference Center to participate in scientific discussions and memorable networking events.

Phil Kellman, PhD, professor, Department of Psychology, UCLA, presented the lecture “From Fragments to Objects: Visual Object Formation Across Gaps in Space and Time.” Robert Marc, PhD, director of research, Moran Eye Center, University of Utah, discussed “Building Retinal Connectomes.” And Marti Arvin, JD, compliance officer, UCLA Health System and David Geffen School of Medicine, offered a thought-provoking lecture on the ethical dilemmas with data collection, creation, and use, which considered who has the rights to the data, how much control a subject should have over additional use, and what are the researcher’s obligations when research creates additional information about a subject.

Aesthetic Eyelid and Facial Rejuvenation Course

The Orbital and Oculoplastic Surgery Division held its annual Aesthetic Eyelid and Facial Rejuvenation course July 19–20, 2013, at the Stein Eye Institute. The event attracted ophthalmologists, dermatologists, and cosmetic surgeons from around the world. The two-day event combined surgical demonstrations, a cadaver dissection, and didactic lectures that informed participants of the latest advances in the field of aesthetic and reconstructive surgery for the eyelids and face.

Distinguished Stein Eye Institute volunteer faculty members, Bruce B. Becker MD, and Jerome R. Klein, MD, were each presented the Senior Teaching Award. Raymond S. Douglas, MD, PhD, associate professor of ophthalmology and visual sciences at the University of Michigan’s Kellogg Eye Center, presented the Faculty members at the 2013 Stein Eye Robert Axelrod, MD, Memorial Lecture. Dr. Douglas conducted his fellowship in Institute Aesthetic Eyelid and Facial orbital facial plastic and reconstructive surgery at the Stein Eye Institute. Rejuvenation Course.

A Year in Review | Stein Eye Institute 11 Optometric Symposium on Advances in Eye Care

Optometrists from across California traveled to the Stein Eye Institute on January 26, 2014, to attend the 16th Annual Stein Eye Institute and Marshall B. Ketchum University joint Optometric Symposium on Advances in Eye Care. Course Chairman Melissa W. Chun, OD, associate clinical professor of ophthalmology, organized the program that included lectures presented by: Michael B. Gorin, MD, PhD, Stacy L. Pineles, MD, Mark H. Sawamura, OD, Irena Tsui, MD, Barry A. Weissman, OD, PhD, and Stanley Woo, OD, MS, MBA.

Pediatric Division Hosts Meeting to Commemorate Dr. Leonard Apt

The Stein Eye Institute Pediatric Division organized and hosted a full-day meeting on April 1, 2014, commemorating the late Leonard Apt, MD, a founding member of the Institute and the first physician to become board certified in both pediatrics and ophthalmology.

More than 40 invited speakers presented timely or controversial material in a rapid-paced format. This is the third time the Pediatric Division has hosted this event, which was held a day prior to the start of the American Association for Pediatric Ophthalmology and Strabismus Annual Meeting in Rancho Mirage, California.

Master’s Orbital Surgery Symposium

The Orbital and Ophthalmic Plastic Surgery Division hosted a Master’s Symposium on Orbital Surgery February 7–8, 2014. The first day of the course was a laboratory session of cadaver dissection, including faculty prosections and hands-on training under faculty guidance. The second day included didactic lectures and case presentations.

The division faculty and guest lecturers, including Raymond S. Douglas, MD, Jeremiah P. Tao, MD, and Jonathan W. Kim, MD, joined course directors Jack Rootman, MD, and Robert Alan Goldberg, MD. Catherine J. Hwang, MD, and Mehryar (Ray) Taban, MD, chaired the laboratory section. The course brought more than 60 participants from across the world, including Attendees of the 2014 Master’s Orbital Brazil, Canada, Colombia, Greece, Iran, Lebanon, Mexico, Netherlands, Spain, Surgery Symposium. Switzerland, Turkey, and the United Kingdom. Many of the attendees were experienced and well-known orbit surgeons, which resulted in a high level of in- terchange of knowledge and collegiality. The success of the course draws from the innovative talent of the Stein Eye Institute’s internationally known faculty, combined with premier facilities for both the laboratory and didactic components of the symposium.

The Orbital Surgery Symposium included presentations, lectures, and hands-on training.

12 Stein Eye Institute | A Year in Review Community Outreach

Much of the Stein Eye Institute’s reputation springs from its innovative vision research, which translates into first-class patient care, including care of those in underserved communities. The Institute’s volunteer arm, the Jules Stein Eye Institute (JSEI) Affiliates, is a broad-based network of volunteers, donors, staff, faculty, fellows, and residents who participate in vision education and patient-care programs throughout Los Angeles. Information about the JSEI Affiliates can be found on the Affiliates website: www.jseiaffliates. com; on Facebook: www.facebook.com/JSEIAffiliates; via email: affiliates@ jsei.ucla.edu; or by calling 310-825-4148.

UCLA Mobile Eye “Pop-up Clinics” Provide Vision Care to Community Schools

The Stein Eye Institute implemented three new “pop-up clinics,” designed to go where the UCLA Mobile Eye Clinic cannot: small preschools in densely populated areas with limited parking and narrow driveways. The Stein Eye Institute received a $4.1 million grant from First Five LA in 2012 to provide free vision screenings to 90,000 preschoolers in underserved areas of Los Angeles County by 2017, and the pop-up clinics help serve that mission. Two boxes the size of laundry baskets hold all the portable equipment needed for an ophthalmologist and an ophthalmic assistant to provide children with dilated eye examinations, prescriptions for eyeglasses, and referrals for further care. The vision teams travel by car with the equipment and set up the pop-up clinics in spare rooms of qualified preschools. “In some areas of Los Angeles, we cannot navigate or park our 40-foot- long bus,” says Faye Oelrich, program manager of the UCLA Mobile Eye Clinic, a community outreach program of the Stein Eye Institute. “We tried to get parents to bring their children to one centralized location for eye examinations, but that required them to travel from their neighborhoods and possibly miss work, which can be a huge barrier to receiving care. The beauty of the pop-up clinics is that we can jump in a car and go to the children.” “We now know that kindergarten is too late to screen children for vision problems,” says Anne L. Coleman, MD, PhD, Fran and Ray Stark Foundation Chair in Ophthalmology and Children who require prescription director of the UCLA Mobile Eye Clinic. “If eyeglasses choose from children need eyeglasses, they need them a selection of frames, and at three years of age to prevent them from eyeglasses are delivered to their getting a lazy eye or an eye that never sees school in one month. well. While pediatricians can identify some children who need eyeglasses, our screening notices subtle differences that could have long-term effects on a child’s vision.” About 17 percent of the children screened need further evaluation, and approximately 9 percent need eyeglasses.

A Year in Review | Stein Eye Institute 13 Jules Stein Eye Institute Affiliates: Helping our Community and Raising Awareness

Make Surgery Bearable Program This year, the JSEI Affiliates in collaboration with the Pediatric Ophthalmology and Strabismus Division, introduced a children’s book, Making Eye Surgery Bearable. The book helps pediatric patients feel more comfortable about the surgical experience by providing age-appropriate information about what they can expect when they come to the Stein Eye Institute. Making Eye Surgery Bearable is given to all young children scheduled for eye surgery at the Institute. Two successful sponsorship events were held this year for the Make Surgery Bearable program. This initiative provides Dr. Teddy bears to each pediatric patient undergoing eye surgery at the Stein Eye Institute. The bears are tagged with the name of the donor, and help children feel comforted and secure during what could otherwise be a frightening time.

MagniVision Program The Affiliates MagniVision program provides financial and volunteer support for the UCLA Vision Rehabilitation Center (VRC). Volunteers train low-vision patients on the use of magnifiers and various vision aids, and financial assistance from the Affiliates enables purchase of low-vision tools for the VRC lending library.

Preschool Vision Screening The Affiliates Preschool Vision Screening program began 14 years ago with the inspiration and support of Mrs. Glorya Kaufman. Under the supervision of the late Dr. Leonard Apt, founding chief of the Division of Pediatric Ophthalmology and Strabismus, initially just a handful of local preschoolers were screened for simple refractive errors and eye muscle problems. In the intervening years, the program has grown substantially. During the 2013–2014 school year, 35 Affiliates volunteers, under the supervision of five retired optometrists, visited 24 preschools to screen 842 children between three and five years of age. Dr. Dean Bok is flanked by JSEI Affiliates volunteers Toshka Abrams (L) and Shared Vision Program Marcia Lloyd (R). The Affiliates Shared Vision program collected and recycled approximately 2,800 donated eyeglasses for those in need this year. Recycled eyeglasses were cleaned, tagged with the vision correction, and distributed to clinic missions conducted by nonprofit groups in Africa, Central America, and other developing nations.

Vision Education Vision IN-School (VIS) is a vision education program offered free of charge to fourth- through seventh-grade students in Los Angeles. The curriculum is fun and interactive, covering the anatomy of the eye, the developing eye and possible eye problems, eye care and eye safety tips, and optical illusions. One of the presentation highlights is the dissection of a cow eye. VIS volunteers visited nine different schools this past year, presenting the curriculum to over 400 elementary students. The program’s goal is to create a greater awareness of vision and the eyes, thus inspiring the children to protect their precious gift of sight for a lifetime of good vision.

Vision Walk Jacqueline Lemus and Teresa Closson On October 26, 2013, the Affiliates participated in the seventh annual Los Angeles with Dr. Teddy. Foundation Fighting Blindness Vision Walk, which was held at Griffith Park. The Stein Eye Team, “Volunteers with Vision,” walked the five-kilometer route with approximately 400 other participants to raise awareness and more than $100,000 to advance retinal eye disease research.

14 Stein Eye Institute | A Year in Review Philanthropy

Established in 1966 through the remarkable insight and philanthropy of Dr. and Mrs. Jules Stein, the Stein Eye Institute continues to advance and expand its programs and facilities. Private support is critical for scientific innovations, exceptional education and training, and the finest, most compassionate therapeutic approaches. This fiscal year, hundreds of donors generously supported the Institute’s sight-saving endeavors.

Dr. Walton Li: A Distinguished Alumnus Gives Back

The Chinese philosopher Zhuang Zi said, “Life is finite, while knowledge is in- finite.” Exemplifying this tenet,Walton Li, MD, advanced the wisdom gained from his family before him to future generations, with a $2-million gift to create the Walton Li Chair in Cornea and Uveitis to support the teaching and research activities of the division chief in perpetuity, as well as create novel programs. “This chair was donated in my name,” explains Dr. Li, “because I greatly benefited from the education and training I received at UCLA. My total experience at UCLA shaped my being.”

Stein Eye Institute Director and second Division Chief in Cornea, Bartly J. Mondino, MD, has known Dr. Li for decades and reflects on the gift’s impact, “Dr. Li’s tremendous donation will provide continuity of funding for the Institute and leave a legacy for future leaders in ophthalmology. It will benefit the teaching and research endeavors of the Cornea and Uveitis Division Chief, and underwrite graduate students and postdoctoral fellows, staff and services, and special projects. Furthermore, the endowment will provide financial resources that will allow for the exploration of promising new areas of research.” Dr. Li Shu Fan––Dr. Walton Li’s uncle and role model––was the first doctor in the Li family, and in 1911, he became the first Health Minister of China after the Chinese Revolution. In 1926, Dr. Li Shu Fan was invited to reorganize the first private hospital in Hong Kong, established in 1922. Now known as the Hong Kong Sanatorium and Hospital (HKSH), Dr. Li Shu Fan was the hospital’s chairman of the board of directors and medical superintendent during the ensuing forty years. Dr. Walton Li’s father and another uncle––both physicians––ran the HKSH upon the passing of Dr. Li Shu Fan in 1966. Dr. Li earned his medical degree from UCLA in 1974, and he completed both his residency (1978) and fellowship (1979) in cornea and uveitis at the Institute. In 1980, he established and has since been head of the Department of Ophthalmology at the HKSH. In 2005, he was elected chairman of the board of Dr. Walton Li directors and was appointed as medical superintendent, positions he still holds today. Dr. Li is also chairman of the Li Shu Fan Medical Foundation, an organization that supports HKSH and has endowed several professorships at universities in Hong Kong. Dr. Li’s gift is directly related to the world-class training he received at the Institute and two of his mentors he found particularly inspiring: Thomas H. Pettit, MD, the first Division Chief in Cornea, and Bradley R. Straatsma, MD, JD, the founding director of the Institute. “Dr. Straatsma took a personal interest in my professional and personal development and played a major role in my decision to become an ophthalmologist,” says Dr. Li.

A Year in Review | Stein Eye Institute 15 Dr. Li credits UCLA for his professional success: “Those years [at UCLA] provided me with a good foundation, strong general medical knowledge, and experience, all of which I use in my leadership role at the HKSH. My training enabled me to establish a good eye service in Hong Kong, and to start a department of ophthalmology. We now have 10 eye doctors with various subspecialty expertise—one of the strongest and largest eye departments in Hong Kong.” Dr. Li’s establishment of the Walton Li Chair in Cornea and Uveitis was a natural culmination of his enduring connection to UCLA. As a world-renowned specialist in his field, Dr. Li understands the importance of supporting cutting-edge research and training the next generation of ophthalmologists. “Training and exposure make a difference in patient care,” he affirms. “The future of health care depends on how well we train and prepare future generations of doctors. Supporting the university will ensure that we have the best professors and ad- vancements in research and medical care.” Dr. Mondino concludes, “Through the establishment of the Walton Li Chair in Cornea and Uveitis, Dr. Li further honors our University and Institute by providing support for clinicians and vision-science researchers to pursue improved treatments for disorders of the anterior segment of the eye. My colleagues and I are grateful for and humbled by his generosity.”

May Family Continue Legacy Through Fellowship

UCLA has benefited for decades from the generous philanthropic involvement of the May family; and the family has made another generous commitment through the Wilbur May Foundation to honor the late Mr. Wilbur D. May, third son of Mr. David May, founder of The May Department Stores Company. This most recent gift will establish the Wilbur D. May Fellowship in the Department of Ophthalmology and the Stein Eye Institute at the David Geffen School of Medicine at UCLA. “The May family has long been a pillar of support to Stein Eye and we are honored to have such patronage and friendship,” says Bartly J. Mondino, MD, director of the Stein Eye Institute and chairman of the UCLA Department of Ophthalmology. “Their generous investment will have a significant impact on the training of fellows and the advancement of ophthalmology.” The Wilbur May Foundation has an enduring history of dedicated involvement Mr. Wilbur D. May with the Stein Eye Institute. Mr. Wilbur May was the beloved uncle of Mr. David May II, past president of the Wilbur May Foundation and one of six original members of the Stein Eye Board of Trustees. The May Family has demonstrated their commitment to Stein Eye training and education programs for decades through the creation of scholarships benefiting residents, fellows, and faculty: The David May II Chair in Ophthalmology was established in 1998 to perpetuate in memoriam Mr. May’s association with the Stein Eye Institute; and the David May II Fellowship Fund was established in 1992 to support advanced study and research in ophthalmology and vision sciences. Today, Mr. David May II’s widow, Mrs. Dee May, and their children Mrs. Amanda May-Stefan, Ms. Alysia May, Mrs. Dalynn May, Ms. Tommee May, Mrs. Anita May Rosenstein, Mrs. Kathy May Fritz, and grandson Mr. Brian Rosenstein, remain invested in philanthropy. The Wilbur May Foundation is led by the foundation’s President, Mrs. Anita May Rosenstein and Vice Presidents, Ms. Dixie May, Mrs. Dee May, Mrs. Kathy May Fritz, Mrs. Amanda May Stefan, Ms. Alysia May, Ms. Tommee May, and Mr. Brian Rosenstein. After consulting with Dr. Mondino and M. Gail Summers, director of Development, last fall, and motivated by Stein Eye’s tradition of excellence in clinical care, vision science, and education of future ophthalmologists, the May family decided to renew their support and honor Mr. Wilbur May’s legacy through a Fellowship gift.

16 Stein Eye Institute | A Year in Review Payden Family Honor Brother With Philanthropic Gift

A generous gift made through the William R. Payden Fund has established the William R. Payden Fund for Glaucoma Research at UCLA’s Stein Eye Institute. This meaningful gift will support the research of Joseph Caprioli, MD, David May II Endowed Chair in Ophthalmology and chief of the Glaucoma Division. “We are very excited by the potential of the fund,” says Bartly J. Mondino, MD, director of the Stein Eye Institute and chairman of the UCLA Department of Ophthalmology. “The Payden family’s loyal commitment allows the Institute to pursue critical advances in education and research for the Glaucoma Division.” The fund represents a continuation of an important Payden family legacy supporting the vision sciences. Ms. Joan Ann Payden, CFA, knew that her beloved brother, Mr. William R. Payden, had wished to create this fund during his lifetime so that Dr. Caprioli and his team could continue dedicating their efforts to finding new advances for the early detection and treatment of glaucoma and in providing the highest quality care available for patients inflicted with this disease. The creation of this fund in his memory allows Mr. Payden’s wishes to come to fruition. “Independent, unrestricted support is essential for developing new clin- Mr. William R. Payden ical protocols with which to treat glaucoma. Bill Payden was an astute and keen student of glaucoma research, and I believe he would enthusiastically approve of the work that will be conducted with the help of these funds,” says Dr. Caprioli. Mr. Payden lived a life full of intellectual curiosity and supported his various passions in music, film, sports, aviation, and philanthropy. He attended the University of Notre Dame and graduated from the University of Colorado where he majored in journalism. Mr. Payden was a reporter and feature writer for the Mamaroneck, New York, Daily News, as well as a public relations associate for a variety of industries in Southern California. Later in life, Mr. Payden found his vo- cation in education and was a journalism professor until he retired from college instruction. He may be most memorialized for his dedication to his students and unquestioned credibility. Mr. Payden passed away in 2013. Through the creation of this fund, Ms. Payden further honors her brother’s legacy and support of education.

A Year in Review | Stein Eye Institute 17 Thank You

e are grateful for the generous and steadfast support the Stein Eye Institute receives for research, education, patient care, and outreach activities. This Winvestment has a positive impact on ophthalmology, related disciplines at UCLA, and throughout the broader vision community. Thank you for your commitment to advancing eye research and treatment for the preservation and restoration of vision throughout the world.

Major Gifts over $25K:

Abbott Lin Hsiung Chen Memorial Scholarship Foundation The Ahmanson Foundation Macula Vision Research Foundation Anonymous Wilbur May Foundation Diane and Robert Bigelow Ruth and George E. Moss Peter S. Bing, MD The Nicholas Endowment Bruce Ford and Anne Smith Bundy Foundation Gail and Jerry Oppenheimer The Carl & Roberta Deutsch Foundation Gerald Oppenheimer Family Foundation David Fett, MD William R. Payden Randi Levine Fett Research to Prevent Blindness, Inc. Carol and Timothy W. Hannemann Albert Sarnoff Tom and Mary Ann Hays The Gerald Schwartz & Heather Reisman Foundation Heidelberg Engineering Beth and David Shaw Estate of Eileen H. Hess The Simms/Mann Family Foundation John and Susan Hess The Skirball Foundation Katrina vanden Heuvel Allan E. Smidt and Dorothy Lou Smidt William & Margaret Fern Holmes Family Foundation Jerome and Joan Snyder The Karl Kirchgessner Foundation Bradley and Ruth Straatsma Knights Templar Eye Foundation, Inc. Norman and Alice Tulchin Walter Lantz Foundation Vision of Children Foundation, Sam and Vivian Hardage, Co-Founders David and Susan Leveton, Ann C. Rosenfield Fund Pat and Joe Yzurdiaga Bert O. Levy

18 Stein Eye Institute | A Year in Review Laraine and David Gerber Chair in Endowed Chairs and Ophthalmology Fellowships Established in 1998 as a term ENDOWED CHAIRS chair by Mr. and Mrs. Gerber and converted to a permanent chair in The Ahmanson Chair in 2007 with an additional pledge Ophthalmology Established in 2005 by The Joseph L. Demer, MD, PhD Ahmanson Foundation as an 2000–2004 The following individuals were administrative chair for the Retina Sherwin J. Isenberg, MD honored with a tribute gift this Division Chief to further research, 2004–Present past year: education, and clinical care programs Steven D. Schwartz, MD Dolly Green Chair of Ophthalmology In Honor of: 2007–Present Anthony J. Aldave, MD Established in 1980 by Ms. Dorothy Leonard Apt Endowed Chair in (Dolly) Green John D. Bartlett, MD Pediatric Ophthalmology Dean Bok, PhD Ilene S. Berg Established in 2003 by Professor 1984–Present Anne M. Bodenheimer Emeritus of Ophthalmology and Founding Director of the Division Joseph Caprioli, MD Ernest G. Herman Chair in of Pediatric Ophthalmology and Ophthalmology Joseph L. Demer, MD, PhD Strabismus, Dr. Leonard Apt, with Initiated in 2007 by Mr. Ernest G. Scott Feiler, MD a gift from the trust of Frederic G. Herman to support a vision scientist Rappaport, Dr. Apt’s nephew Carol H. Gillis or a clinician-investigator Robert Alan Goldberg, MD Joseph L. Demer, MD, PhD Xian-Jie Yang, PhD 2005–Present 2012–Present Michael B. Gorin, MD, PhD Carole Hamburger Karen and Frank Dabby Endowed Chair in Ophthalmology Jean-Pierre Hubschman, MD Established in 2007 by Dr. and Mrs. Nancy Kramer Dabby as a term chair to support Allan E. Kreiger, MD the activities of a distinguished faculty member in the area of orbital Jule D. Lamm, OD disease Kevin M. Miller, MD Robert Alan Goldberg, MD George E. Moss 2008–Present Bradley R. Straatsma, MD, JD Charles Kenneth Feldman Chair in Ophthalmology In Memory of: Established in 1982 by various Peggy L. Giambrocco donors in memory of Charles Kenneth Feldman, an entertainment industry executive Robert D. Yee, MD Professor 1984–1987 Hillel Lewis, MD Scholar 1989–1993 Gabriel H. Travis, MD 2001–Present

A Year in Review | Stein Eye Institute 19 Karl Kirchgessner Foundation David May II Endowed Chair in Jerome and Joan Snyder Chair in Chair in Vision Science Ophthalmology Ophthalmology Established in 2001 as a term chair Established in 1998 as a term chair Established in 2007 by Mr. and Mrs. by a colleague of Dr. Jules Stein by the family of Mr. David May II, a Snyder to support the activities of to promote basic-science research founding member of the Institute’s a distinguished faculty member initiatives Board of Trustees, to perpetuate, in who directs the Ophthalmology Debora B. Farber, PhD, DPhhc memoriam, Mr. May’s association Residency Program, ensuring 2001–Present with the Stein Eye Institute and that UCLA’s accredited program converted to a permanent chair with continues to offer rigorous and Kolokotrones Chair in an additional pledge from the Wilbur comprehensive instruction for Ophthalmology May Foundation individuals of the highest caliber Established in 2004 by Wendy and Gary N. Holland, MD Anthony C. Arnold, MD Theo Kolokotrones to support the 1999–2004 2008–Present teaching and research of a cataract surgeon and scientist Joseph Caprioli, MD Joan and Jerome Snyder Chair in 2004–Present Cornea Diseases Kevin M. Miller, MD Established in 2012 by Mr. and Mrs. 2005–Present Oppenheimer Brothers Chair Snyder to support the activities of Established in 2002 as a term chair Grace and Walter Lantz Endowed a distinguished faculty member in by the Oppenheimer Brothers Chair in Ophthalmology the area of corneal diseases and Foundation Established in 1991 as a term chair research Joseph Horwitz, PhD by Mr. and Mrs. Lantz and converted The Fran and Ray Stark 2003–Present to a permanent chair in 2010 with an Foundation Chair in additional pledge Ophthalmology Harold and Pauline Price Chair in J. Bronwyn Bateman, MD Ophthalmology Established in 1992 as a term Grace and Walter Lantz Scholar Established in 2000 by the Louis chair by the Fran and Ray Stark 1993–1995 and Harold Price Foundation and Foundation and converted to a converted to a permanent chair in permanent chair in 2007 with an Sherwin J. Isenberg, MD additional commitment Grace and Walter Lantz Scholar 2006 with an additional pledge 1993–1995 Michael B. Gorin, MD, PhD Joseph Caprioli, MD Professor 1996–2004 2006–Present 1997–2004 Anne L. Coleman, MD, PhD Joseph L. Demer, MD, PhD Arthur L. Rosenbaum, MD Chair in 2004–Present Professor 2004–2005 Pediatric Ophthalmology Established in 2005 by Mr. and Walton Li Chair in Cornea Jules Stein Chair in and Uveitis Mrs. Gottlieb as an administrative Ophthalmology chair for the Division of Pediatric Established in 2013 by Walton W. Established in 1982 as a memorial Ophthalmology and Strabismus, Li, MD, as an administrative chair for tribute to Dr. Jules Stein by his in honor of the late Dr. Arthur L. the Cornea and Uveitis Division chief many friends, with the leadership of Rosenbaum to further research and teaching Mr. Samuel Goldwyn, Jr. activities Arthur L. Rosenbaum, MD Wayne L. Hubbell, PhD 2008–June 2010 Anthony J. Aldave, MD 1983–Present 2014–Present Jack H. Skirball Chair in Ocular Bradley R. Straatsma, MD Endowed Inflammatory Diseases Chair in Ophthalmology Initiated in 2007 by The Skirball Established in 1994 to honor Founding Foundation in honor of Jack H. Director of the Stein Eye Institute, Skirball’s long-standing friendship Bradley R. Straatsma, MD, JD with Dr. Jules Stein and Lew Wasserman Bartly J. Mondino, MD 2000–Present Gary N. Holland, MD 2009–Present

20 Stein Eye Institute | A Year in Review Vernon O. Underwood Family Edith and Lew Wasserman ENDOWED FELLOWSHIPS Chair in Ophthalmology Professor of Ophthalmology Rosalind W. Alcott Fellowship Established in 1995 as a term chair Established in 1977 by Edie and Lew by Mrs. Adrienne Underwood Wasserman to honor Dr. Jules Stein Established in 1978 by the Rosalind W. Alcott Charitable Remainder Pingree in memory of her late Manfred Spitznas, MD husband, Mr. Vernon O. Underwood Trust for the training of outstanding 1979–1981 postdoctoral fellows John R. Heckenlively, MD Bartly J. Mondino, MD 1997–2004 Ryan St. Clair, MD Scholar 1984–1988 2013–2014 Gary N. Holland, MD Professor 1988–2000 2004–2009 Leonard Apt Endowed Fellowship Ben J. Glasgow, MD in Pediatric Ophthalmology Lynn K. Gordon, MD, PhD 2003–Present Established in 2002 by Founding 2012–Present Chief of the Pediatric Ophthalmology and Strabismus Division, Leonard Apt, MD, to support outstanding clinical fellows in the field of pediatric ophthalmology and strabismus Anika Tandon, MD 2013–2014

Thelma and William Brand Director’s Fund Established in 2004 with a trust from Mr. William F. Brand to benefit worthy students at the Stein Eye Institute Joshua Udoetuk, MD 2013–2014

Cooperman Fellowship Fund Established in 1988 by the Coopermans to support eye research and education, with emphasis on clinical ophthalmology Joshua Udoetuk, MD 2013–2014

David and Randi Fett Orbital and Ophthalmic Plastic Surgery Fellowship Endowment Established in 2013 by Dr. and Mrs. Fett to support fellows in the Orbital and Ophthalmic Plastic Surgery Division

Klara Spinks Fleming Fellowship Fund Established in 1985 by Klara Spinks Fleming to support cataract research Rosalind Vo, MD 2013–2014

A Year in Review | Stein Eye Institute 21 Frances Howard Goldwyn David May II Fellowship Fund Adelaide Stein Miller Research Fellowship Established in 1992 by the family Fellowship Established in 1977 by Mr. Samuel of Mr. David May II to support Established in 1977 by Mr. Charles Goldwyn, Jr., with gifts from Mrs. advanced study and research in Miller as a tribute to Dr. Jules Stein’s Goldwyn’s estate and Dr. and Mrs. ophthalmology and vision science sister Jules Stein Renu Jivrajka, MD Erica Oltra, MD Alena Reznik, MD 2013–2014 2013–2014 2013–2014 John and Theiline McCone Harold and Pauline Price Elsa and Louis Kelton Fellowship Fellowship Fellowship Endowed by the Keltons in 1982 to Established in 1989 by the McCones Established in 1986 by the Louis support postdoctoral research and to support and enhance education and Harold Price Foundation to training programs and fellowship training in support research and education in ophthalmology and vision care Payam Morgan, MD macular disease 2013–2014 David Cupp, MD Anika Tandon, MD 2013–2014 2013–2014 Bert Levy Research Fellowship Fund Sujit Itty, MD Frederic G. Rappaport Fellowship Established in 1995 by Mr. Bert 2013–2014 in Retina/Oncology Levy to enhance the educational Established in 2004 by Mrs. Jeanne Abe Meyer Memorial opportunities of vision science A. Rappaport as a memorial to her Fellowship Fund scholars and advance research in son Frederic Established in 1969 by various neuro-ophthalmology donors to support clinical fellows at Sujit Itty, MD Wilbur D. May Fellowship the Institute 2013–2014 Established in 2013 by the May Saradha Iragavarapu, MD Dr. Jack Rubin Memorial family as a tribute to Mr. Wilbur D. 2013–2014 Fellowship May, the beloved uncle of Mr. David Established by the family of Dr. May II. Jack Rubin to support postdoctoral fellows

22 Stein Eye Institute | A Year in Review Sanford and Erna Schulhofer Herb Ritts, Jr., Memorial Vision Fund Fellowship Fund Endowments for Research, Education, and Patient Care Arna Saphier Macular Degeneration Established in 1986 by Mr. Sanford Fund Schulhofer to support postdoctoral The Annenberg Foundation Fund research and training in vision Albert Sarnoff Endowed Cataract J. Richard Armstrong and Ardis science Fund Armstrong Fund Ryan Wong, MD Richard B. Shapiro Vision Fund 2013–2014 Elsie B. Ballantyne Regents Fund The Skirball Foundation Fund Lee and Mae Sherman Elsie B. Ballantyne UCLA Foundation Fellowship Fund Fund Arthur Spitzer Fund Established in 1981 by the Sherman Virginia Burns Oppenheimer Dr. William F. Stein and Esther family to support postdoctoral Endowment Fund Elizabeth Stein Memorial Fund fellows Card Family Research Fund Raymond and Ruth Stotter Vision Daniel Rootman, MD Science Research Fund 2013–2014 Edward and Hannah Carter Fund Bradley R. Straatsma Research Fund Audrey and Jack Skirball Ocular Anthony Eannelli Fund Barbara P. Taylor Fund Inflammatory Disease Fellowship Katherine L. Gardner Research Fund Established in 2011 by The Skirball UCLA Center for Eye Epidemiology Foundation to support the training Emma B. Gillespie Fund Paul J. Vicari Endowed Cataract of fellows specializing in ocular Audrey Hayden-Gradle Trust inflammatory disease Research Fund Marie and Jerry Hornstein Family Ryan St. Clair, MD Uncle Claude Fund 2013–2014 Endowed Macular Degeneration Research Fund Anne H. West Estate Fund Jules Stein Research Fellowship Michael Huffington Ophthalmology Daniel B. Whipple Fund Established in 1982 by various Scholarship Fund donors to honor the memory of Pat and Joe Yzurdiaga Endowed Charles Kenneth Feldman Stella F. Joseph Fund Cataract Fund Ryan Wong, MD JSEI Maintenance Fund 2013–2014 Herman King Fund The Karl Kirchgessner Foundation Ophthalmology Endowment Fund

Sara Kolb Memorial Fund John and Theiline McCone Macular Disease Research Fund William, Richard, and Roger Meyer Fund Chesley Jack Mills Trust Patricia Pearl Morrison Research Fund William R. Payden Fund for Glaucoma Research Gerald Oppenheimer Family Foundation Center for the Prevention of Eye Disease Endowment Fund Jerome T. Pearlman, MD, Fund Emily G. Plumb Estate and Trust

A Year in Review | Stein Eye Institute 23 The legacy of Dr. and Mrs. Jules Stein arises from their role in the 20th century as visionaries. Through brilliance and beneficence, they created a multitude of programs aimed specifically at one goal: preserving and restoring eyesight. They approached this task dauntlessly, integrating the worlds of business, medicine, and philanthropy in such a way as to enhance each and leave in trust the promise of limitless accomplishment in the advancement of eye research and treatment. The Stein Eye Institute was established as a result of their philanthropy.

24 Stein Eye Institute | A Year in Review related to vision, ophthalmic education, and the care of pa- Jules Stein tients with eye disease. Jules Stein died in 1981, leaving a Jules Stein is the fore- legacy of hope to the world. Through his accomplishments most benefactor in the and philanthropy, he created ever-replenishing resources world history of vision for eye research and the means to preserve and restore science and blind- sight for future generations. ness prevention. He combined his love for music and medicine Doris Stein with a unique talent Doris Stein’s purposeful, yet richly varied life, earned the for analysis and orga- respect and affection of the many people who benefited nization to produce a from her humanitarianism. Inspiring partner of her husband lifetime of celebrat- for more than half a century, Doris Stein shared with him ed achievements as the accomplishments of his philanthropic endeavors and musician, physician, guided his interests in ophthalmology, beginning with a business leader, and visit to the New York Lighthouse for the Blind in the late humanitarian. 1950s. Deeply moved, Doris Stein urged her husband to Born in South Bend, Indiana, in 1896, Jules Stein received “do something!” From that passionate beginning came a a bachelor of philosophy degree from the University of broad base of programs that catalyzed eye research. Chicago at age 18 followed by a medical degree from Rush Doris Stein was a major force in this vision renaissance. She Medical College. After completing postgraduate studies served as an officer and director of Research to Prevent at the University of Vienna and Chicago’s Cook County Blindness, personally leading the Hospital, he began medical practice and was certified by appeal to establish more resourc- the American Board of Ophthalmology. es for investigations into eye dis- A musician from an early age, he financed his education by eases. She suggested that Jules playing in and leading his own band. As his reputation in- Stein assume the principal role in creased, he began booking other musicians for profession- the creation of an eye institute al engagements, and in 1924, founded Music Corporation at UCLA, and her unflagging en- of America (MCA). Shortly thereafter, he gave up the prac- thusiasm nurtured the Institute’s tice of medicine to concentrate on this enterprise. Within development as a unique pro- 10 years, MCA represented most of the great name bands vider of every facet of vision re- and corporate activities began to extend to representa- search and patient care. Serving tion of film stars, directors, writers, and musical artists. as Trustee, she focused special MCA entered the promising new field of television at its attention on Institute initiatives inception, eventually acquiring the Universal City property, to combat blindness throughout Universal Pictures, and other enterprises to become pre- the world. She devoted her last eminent in the entertainment industry. days, until her death in 1984, to the development of an expansion Throughout his phenomenally successful career, Jules and companion building for eye Stein maintained a strong interest and emotional invest- research. In 1989, dedication ceremonies were held for the ment in medicine, particularly his own field of ophthalmol- Doris Stein Eye Research Center. ogy. In the late 1950s, urged by his wife, Doris, he chose to direct his considerable talents to blindness prevention. With grace, vision, and meaningful action, Doris Stein en- The result was a concert of ideas and achievements that hanced the lives of all privileged to know her, stimulated encompassed philanthropy, government, and academic a cascade of progress in eye research, co-founded the medicine. Institute with its boundless scientific potential, and extend- ed the miracle of sight to untold numbers of people. By his efforts, Research to Prevent Blindness was created, now recognized as the world’s leading voluntary organization in support of studies of the eye and its diseases. Jules Stein was largely responsible for the passage of legisla- tion to establish the National Eye Institute as a separate entity in the National Institutes of Health. Under his leadership, the Stein Eye Institute was founded as a multidisciplinary center for vision science. Since its establishment, the Institute has become internationally identified as the focus for coordinated programs of research in the sciences

A Year in Review | Stein Eye Institute 25 Board of Trustees The Stein Eye Institute Board of Trustees was established in 1977 to ensure the Institute’s orderly growth and development. The Board meets regularly during the year, with each Trustee providing his/her unique counsel. Collectively, their invalu- able contributions have included fiscal planning for the Institute, adoption of measures to facilitate recruitment of the world’s finest vision scientists, allocation of funds for the purchase of vision research equipment, and recommendations for facilities expansion programs.

Current Members

Nelson C. Rising, Esq. Bartly J. Mondino, MD Chairman and Director Chief Executive Officer Stein Eye Institute Rising Realty Partners 1994–present 2011–present

Ronald L. Olson, Esq. Katrina Vanden Heuvel Partner Publisher and Editor Munger, Tolles, and Olson The Nation Magazine 1995–present 1984–present

Gerald H. Oppenheimer President Gerald Oppenheimer Casey Wasserman Family Foundation President and President Chief Executive Officer Systems Design Associates The Wasserman Foundation 1992–present 1998–present

Andrea L. Rich, PhD Retired President, Chief Executive Officer, and Director Los Angeles County Museum of Art Executive Vice Chancellor Emerita UCLA 2007–present* *Dr. Rich passed away July 28, 2014

26 Stein Eye Institute | A Year in Review Executive Committee Director, Stein Eye Institute Chairman, UCLA Department of Ophthalmology Bartly J. Mondino, MD Associate Directors, Stein Eye Institute Wayne L. Hubbell, PhD Gabriel H. Travis, MD Vice-Chairs, UCLA Department of Ophthalmology Sherwin J. Isenberg, MD Anne L. Coleman, MD, PhD Chief Administrative Officer, Stein Eye Institute Jonathan D. Smith

Jules Stein Eye Institute Executive Committee (sitting from left to right): Drs. Bartly Mondino, Sherwin Isenberg, Anne Coleman, and Gabriel Travis; (standing from left to right) Dr. Wayne Hubbell and Mr. Jonathan Smith.

A Year in Review | Stein Eye Institute 27 The Stein Eye Institute at UCLA is a vision-science campus dedicated to the preservation and restoration of vision through its global programs and innovative research, quality patient care, and multidisciplinary, integrative education, all with community outreach.

28 Stein Eye Institute | A Year in Review FACULTY Honors Anthony J. Aldave, MD Awarded the gold medal for contributions to the field of ophthalmology by the Intraocular Walton Li Chair in Cornea and Uveitis Implant and Refractive Society on September 8, 2013, in Professor of Ophthalmology New Delhi, India. Chief of the Cornea and Uveitis Division Delivered the Roger F. Meyer, MD, Lectureship in Cornea on September Member of the Stein Eye Institute 19, 2013, at the University of Michigan in Ann Arbor, Michigan.

Public Service RESEARCH SUMMARY Chair, International Advisory Committee Discovering the Genetic Basis of the Corneal Dystrophies of Tissue Banks International Chair, American Academy of Ophthalmology Knowledge Base The Cornea Genetics Laboratory, under Dr. Aldave’s direction, is involved in Development Project, Cornea and identifying and elucidating the genetic basis of inherited corneal disorders, External Disease Panel such as posterior polymorphous and Lisch corneal dystrophies. Vice Chair, American Academy of Ophthalmology Ethics Committee Associate Examiner, American Board of Ophthalmology Member, Cornea Society Board of Directors Reviewer for many scientific journals

Research Grants National Eye Institute: Identification and Characterization of the Genetic Basis of PPCD, 12/1/12–11/30/17 JAEB Center for Health Research: Effect of the Corneal Preservation Time on Long-Term Graft Success (CPTS), 3/6/12–8/31/16

30 Stein Eye Institute | Faculty Honors Anthony C. Arnold, MD Recipient of the North American Neuro-Ophthalmology Society’s (NANOS) Distinguished Service Award Jerome and Joan Snyder Chair in Ophthalmology presented on March 5, 2014, at the NANOS Annual Meeting in San Juan, Professor of Clinical Ophthalmology Puerto Rico. Chief of the Neuro-Ophthalmology Division Inducted into the American Ophthalmological Society on May 15, Director of the UCLA Optic Neuropathy Center 2014, in New York, New York. Member of the Stein Eye Institute Public Service Faculty, Stanford/Bay Area Basic Science Course in Neuro‑Ophthalmology RESEARCH SUMMARY Faculty, Lancaster Course in Ophthalmology, Colby College Ischemic and Inflammatory Diseases of the Optic Nerve Board Director, American Board of Ophthalmology Dr. Arnold directs a neuro-ophthalmol- Ongoing additional research studies Chair, ACGME Residency Review ogy research program concerned with include clinical characteristics of is Committee for Ophthalmology diseases of the optic nerve. The overall chemic optic neuropathy in young pa- Chair, ACGME Milestones Committee goals of the program are the develop- tients; improved differentiation of arte for Ophthalmology ment of new techniques for imaging ritic from nonarteritic anterior ischemic Reviewer for many scientific journals the optic nerve and its blood supply; optic neuropathy; identification of is an improved understanding and classi- chemic aspects of other rare optic fication of ischemic and inflammatory neuropathies, such as diabetic papil- optic nerve diseases; and the develop- lopathy, uremic optic neuropathy, and ment and evaluation of new therapeu- chemotherapy-induced optic neuropa- tic modalities for these diseases. thy after bone marrow transplantation; and classification of unusual optic neu- Dr. Arnold was a principal investigator ropathies, such as ethambutol-induced in the National Eye Institute-sponsored optic neuropathy and focal congenital clinical study of optic nerve sheath de- optic nerve hypoplasia. A study of dif- compression surgery for nonarteritic ferentiation of optic disc drusen from anterior ischemic optic neuropathy, papilledema has recently been com- and he was on the study’s Visual Field pleted. A major thesis entitled, The Data Analysis Committee. He is a pri- Spectrum of Optic Disc Ischemia, has mary advisor for an international multi- been submitted to the American Oph- center study of risk factors for nonarte- thalmological Society. ritic anterior ischemic optic neuropathy.

Faculty | Stein Eye Institute 31 Public Service Richard S. Baker, MD Board Member, California Medical Association

Associate Professor of Ophthalmology Chairman, Council for Scientific and Clinical Affairs, California Executive Director, Urban Health Institute Medical Association Chairman, Department of Ophthalmology Chairman, African American Physician Charles R. Drew University of Medicine and Science Advisory Committee, Los Angeles County Medical Association Member of the Stein Eye Institute Board Member, Latino Physicians of California Board Member, Hispanic-Serving Health Professions Schools RESEARCH SUMMARY Co-Founder and Board Member, Ophthalmic Epidemiology Los Angeles Eye Institute and Health Services Member, South Los Angeles Health Care Leadership Roundtable Research Reviewer for multiple NIH and AHRQ Special Emphasis Panels Dr. Baker’s primary areas of research Reviewer for many scientific journals interest are in the fields of ophthalmic epidemiology, health services research, and health information technology including telemedicine. Current projects in ophthalmic epidemiology include statistical analysis of national and statewide databases to produce definitive population-based estimates of the distribution and the determi- nants of major ophthalmic diseases and their treatments. As director of the Charles Drew Cen- ter for Health Services Research, Dr. Baker works closely with collab- orators at the Stein Eye Institute and across UCLA on multiple projects related to improving access to care, op- timizing the quality of care, and elim- inating health disparities in diverse and underserved populations.

32 Stein Eye Institute | Faculty Public Service Suraj P. Bhat, PhD Member, Joint Working Group INDO-US Collaboration in Vision Research Associate Professor of Ophthalmology Assessor, National Health and Member of the Molecular Biology Institute Medical Research Council, Australia Member of the Stein Eye Institute Editor, Molecular Vision Editorial Board Member, Developmental Neuroscience Editorial Board Member, RESEARCH SUMMARY International Journal of Biochemistry and Molecular Biology Molecular Biology of Vision Reviewer for many scientific journals

Dr. Bhat’s laboratory studies the regu- of this cataract, thus enabling first- lation of gene activity during differen- time investigation of this childhood tiation and development of the verte- pathology. brate eye. This involves isolation and characterization of genes and gene Studies on the function of the αB- products, identification of the regula- crystallin protein in the lens and the tory elements and factors, and eluci- RPE (in particular its relation to AMD) dation of their mechanisms employ- are focused on elucidating its “non- ing both in vivo and in vitro paradigms crystallin” function, which is relevant with manipulated gene sequences. both in the transparent and nontrans- parent physiology. These investiga- Two areas of research currently under tions in Dr. Bhat’s laboratory have investigation are focused on gaining led to the discovery of the secretion deeper insight into molecular mech- of αB-crystallin from the RPE in lipo- anisms that developmentally predis- protein vesicles known as exosomes, pose the eye to visual impairment and initiated studies on elucidation through ocular lens pathologies such of intercellular communication (via as cataracts, and through retinal dis- exosomes) in the RPE, in health, and eases including age-related macular in disease. degeneration (AMD). One area of attention is the study of the developmental and tissue-specific control of the heat shock promoter of the αB-crystallin gene and its involvement in cataractogenesis. Another is the elucidation of the physiological function of the αB-crystallin protein in the ocular lens, in the neuroretina and retinal pigment epithelium (RPE), and in the brain. Technically this work involves gene manipulations and the study of their consequences on the phenotype, both in vitro (cultured cells) as well as in vivo (transgenic animals). Studies on the regulation of the expression of the small heat shock protein gene, αB-crystallin are focused on heat-shock transcription factor 4 (HSF4), which Dr. Bhat’s laboratory has reported to be the predominant heat shock transcription factor of the developing ocular lens and whose post-natal expression correlates with the most prevalent form of early childhood lamellar cataracts. Dr. Bhat’s laboratory has generated mouse models

Faculty | Stein Eye Institute 33 Honors Joseph Caprioli, MD Presented the Irvine Lecture, Rates of Functional Damage from Glaucoma, on June 21, 2014, David May II Endowed Chair in Ophthalmology at the Doheny Eye Institute in Los Angeles, California. Professor of Ophthalmology Chief of the Glaucoma Division Public Service Chair, American Academy of Member of the Stein Eye Institute Ophthalmology, Committee on Practice Improvement Clinical Volunteer, Venice Family Clinic

RESEARCH SUMMARY Editorial Board Member, American Journal of Ophthalmology, Causes and New Treatments for Glaucoma Investigative Ophthalmology and Visual Science, and Journal of Glaucoma Reviewer for many scientific journals Dr. Caprioli’s long-term objective in Molecular Mechanisms of his clinical and basic research is to Retinal Ganglion Cell Damage Research Grants identify those individuals at greatest and Neuroprotective Approaches Heidelberg, Engineering: Multicenter risk for visual loss and to implement to Treatment Study for Normal Database of Optic new treatment strategies to prevent Basic science research under Dr. Cap- Nerve Head, Retinal Nerve Fiber blindness. Currently, the only tool that rioli’s direction involves the mecha- Layer, and Macula Parameters, with the Heidelberg Spectralis OCT, physicians have to treat glaucoma nisms of glaucomatous optic nerve 9/25/13–9/24/15 is reduction of intraocular pressure. damage. The stress protein response This treatment does not prevent visu- in a glaucoma model is being inten- al loss in a substantial proportion of sively studied. An important goal in patients whose damage progresses this research is to identify neuropro- quickly. The development of effective tective drugs that prevent the death neuroprotective avenues of treatment of retinal ganglion cells in mammali- will be a hallmark advance to elimi- an models of glaucoma, and to apply nate blindness from this disease. these findings to clinical trials of human glaucoma. Evaluation of Methods to Measure Rates of Glaucomatous Optic Nerve Damage Accurate assessment of optic nerve and nerve fiber layer is important to the early detection and timely treatment of glaucoma. Studies are underway to develop novel structural measures of the optic nerve and nerve fiber layer, which are sensitive and specific for early and progressive glaucomatous optic nerve damage. The goals of this work include identifying clinically implementable techniques to measure the rate of progressive damage. It is unlikely that a single structural or functional technique will be best throughout the course of the disease, and different methods will need to be applied at different stages to best measure disease progression.

34 Stein Eye Institute | Faculty Public Service Richard Casey, MD Lead Physician, Martin Luther King, Jr. Multi-Service Ambulatory Care Center

Health Sciences Clinical Professor of Ophthalmology President, Los Angeles Ophthalmology Medical Group, Inc. Associate Member of the Stein Eye Institute

RESEARCH SUMMARY Cornea External Disease

Dr. Casey’s research is focused on Public Health Services/ understanding the causes of corneal Health Access disease and developing or improving Dr. Casey has elected to dedicate a treatments for patients with these significant portion of his professional disorders. He is collaborating with career to improving access to health the Glaucoma and Ophthalmic Pa- care in specific underserved commu- thology Divisions on clinical research nities of Los Angeles. He has focused projects to understand the nature of on assessing unmet needs in vision comorbid conditions, such as glauco- health and developing innovative strat- ma and dry eye disease. For dry eye egies to meet these deficits. He has disease, Dr. Casey is engaged in re- established the Los Angeles Ophthal- search to evaluate the ocular surface mology Medical Group, a comprehen- of patients undergoing corneal trans- sive eye care service entity, which is plantation surgery to establish previ- currently engaged in a partnership to ously undescribed clinical-pathologic provide eye care services to facilities correlation with tear insufficiency and of the Los Angeles County, Depart- corneal epithelial abnormalities. The ment of Health Services in South goal of these investigations is to im- Los Angeles. prove the success of corneal transplantation in high-risk patients with the comorbid conditions of glaucoma, and separately, tear insufficiency.

Faculty | Stein Eye Institute 35 Public Service Anne L. Coleman, MD, PhD Director/Trustee, St. John Jerusalem Eye Hospital Group

The Fran and Ray Stark Foundation Chair in Ophthalmology Member, Awards Committee, Association for Research in Vision Professor of Ophthalmology and Ophthalmology Professor of Epidemiology Chair, Planning Committee, National Eye Health Education Director of the Stein Eye Institute Centers for Community Outreach and Policy, Program, National Eye Institute Eye Epidemiology, and the UCLA Mobile Eye Clinic Secretary for Quality Care, Vice Chair of Academic Affairs, Department of Ophthalmology American Academy of Ophthalmology Member of the Stein Eye Institute Director, H. Dunbar Hoskins Jr., MD Center for Quality of Eye Care Member, Board of Trustees, Helen Keller International RESEARCH SUMMARY Executive Editor, American Journal Glaucoma, Cataract, and of Ophthalmology

Age-Related Macular Degeneration Research Grants California Pacific Medical Center Dr. Coleman’s research is directed Research Institute: Immune Response toward the diagnosis, treatment, and Gene Polymorphisms and AMD: Examining HLA-KIR Epistasis, societal impact of glaucoma, cataracts, 7/1/11–6/30/14 and age-related macular degeneration, Fight for Sight, Inc. (Prevent Blindness including the study of lifestyle limita- America): Fixation Stability during tions imposed on patients with these Perimetry in Advanced Glaucoma, kinds of eye diseases. Clinical projects 1/1/2012–8/31/2013 include studies that analyze the genet- LA County Children and Families First ic markers in the trabecular meshwork (First 5 LA): UCLA Mobile Eye Clinic of patients undergoing glaucoma sur- Child Vision Program, 7/1/13–6/30/15 gery, the prevention of visual impair- Outcome Sciences, Inc: ARRA: ment and blindness in school-age Evidence Development for Topics Identified as National Priorities for children, comparative effectiveness re Comparative Effectiveness Research, search, and glaucomatous visual field 7/19/10–7/18/14 and optic nerve progression. The Nicholas Endowment: Center for Community Outreach and Policy, Jules Stein Eye Institute at UCLA 2013–2014, 1/1/14–12/31/14

36 Stein Eye Institute | Faculty Honors Joseph L. Demer, MD, PhD Presented the 14th Annual Richard G. Weaver Lecture on June 6, 2014, at Wake Forest University in Leonard Apt Endowed Chair in Pediatric Ophthalmology Winston-Salem, North Carolina. Professor of Ophthalmology Public Service Professor of Neurology Editorial Board Member, Investigative Ophthalmology and Visual Science Chief of the Pediatric Ophthalmology and Strabismus Division Editorial Board Member, Journal of the Member of the Stein Eye Institute American Association for Pediatric Ophthalmology and Strabismus Associate Editor, Strabismus

RESEARCH SUMMARY Grant Reviewer, United States Public Health Service Motility and Vision Scientific Advisory Committee Member, Knights Templar Eye Foundation Dr. Demer studies the role of the brain and extraocular muscles in the control of eye movements and visual perception. He is directing a National Eye Institute re- Council Member, International Strabismological Association search project aimed at developing an understanding of the role of orbital connective tissues and nerves in the development of binocular coordination disorders, Reviewer for many scientific journals such as strabismus, and is developing new technologies for magnetic resonance imaging of extraocular muscles and nerves. This research has contributed to the Research Grants knowledge of the functional anatomy of extraocular muscles and connective National Eye Institute: Biomechanical Analysis in Strabismus Surgery, tissues, allowing development of new types of surgeries. 5/1/11–4/30/16 Dr. Demer’s research also employs novel micro- and nano-technological tech- Knights Templar Eye Foundation Inc.: Gesite-de Leon, Bhambi Uellyn: niques to study the biomechanical properties of the extraocular muscles and as- Training Mentors in Developing sociated tissues, as well as optical and x-ray imaging of the effects of physiological Countries (TMDC) Pediatric forces in the tissues. Ophthalmology Fellowship, 7/1/13–6/30/14

Faculty | Stein Eye Institute 37 Public Service Sophie X. Deng, MD, PhD Member, American Academy of Ophthalmology Ophthalmic Technology Assessment Committee, Cornea and Associate Professor of Ophthalmology Anterior Segment Disorders Panel Member of the UCLA Jonsson Comprehensive Cancer Center Research Grants National Eye Institute: Ex Vivo Member of the UCLA Broad Stem Cell Research Center Expansion of Human Limbal Stem Cells for Transplantation, Member of the Stein Eye Institute 9/1/12–8/31/17

RESEARCH SUMMARY Limbal Stem Cell Deficiency

Dr. Deng’s research is focused on The second project in Dr. Deng’s lab- improving the current diagnosis and oratory is to achieve patient-specific treatments for patients with limbal therapy by regenerating autologous stem cell deficiency. One of the on- limbal stem cells in a xenobiotic- going clinical studies that Dr. Deng free culturing system for transplan- conducts shows correlated cellular tation. Her laboratory has developed changes in the cornea and limbus, us- xenobiotic-free and feeder-free cul- ing laser scanning in vivo confocal mi- ture methods to expand autologous croscopy in patients with limbal stem limbal stem cells in culture. Preclini- cell deficiency. Damages to the limbal cal studies are ongoing to bring this stem cells could be detected using stem cell therapy to restore vision in this new technology and correlated patients who suffer from limbal stem with clinical presentation. This new cell deficiency. technique could allow for a better understanding of the pathophysiology of limbal stem cell deficiency. Another study focuses on finding a better diagnostic marker for limbal stem cell deficiency. By using the new diagnostic marker and the in vivo confocal image study, a timely diagnosis and staging of disease progression could be achieved. Dr. Deng’s laboratory studies the microenvironment/niche of the limbal stem cells to elucidate those factors that govern the fate of limbal stem cells. The role of the Wnt signal transduction pathway in human limbal stem/ progenitor cells is under investigation. Recent study in her laboratory reveals that activation of the Wnt/ß-catenin promotes self-renewal of limbal stem cells and that Frizzled 7 might be the receptor that mediates the Wnt activation. Use of small molecules to modulate Wnt signaling is being inves tigated to increase the efficiency of ex vivo expansion of limbal stem cells for transplantation.

38 Stein Eye Institute | Faculty Honors Gordon L. Fain, PhD Elected as a Fellow of the American Academy for the Advancement of Science on November 25, 2013. Distinguished Professor of the Departments of Elected as an Overseas Fellow of Integrative Biology/Physiology and of Ophthalmology Churchill College Cambridge, Member of the Stein Eye Institute April 2014–August 2014.

Research Grants National Eye Institute: Physiology of RESEARCH SUMMARY Photoreceptors, 8/1/12–7/31/17 Physiology of Photoreceptors in the Vertebrate Eye

Dr. Fain’s primary research interest is in the physiology of photoreceptors in the vertebrate eye. A vertebrate photoreceptor uses a photopigment called rhodopsin and a G-protein cascade to produce the electrical response that signals a change in light intensity. Powerful new techniques have made it possible to understand the working of this cascade in extraor- dinary detail. Practically all the protein molecules involved in the cascade in a photoreceptor—from the pigment molecule to the G-protein and channels, but also including a large number of control proteins—are expressed only in the photoreceptors and nowhere else in the body. This has enabled scientists to use genetic techniques to create mice in which these proteins have been knocked out, over- or under-expressed, or replaced with proteins of modified structure. Dr. Fain’s laboratory uses electrical recording to study the effects of such genetic alterations on the light responses of mouse rods, in order to understand the role of these proteins in the visual cascade. His research team is especially interested in mod- ulatory enzymes and their function in light and dark adaptation. Dr. Fain also has a long-standing interest in mechanisms of photoreceptor degeneration in genetically inherited disease. His laboratory is presently the only laboratory measuring changes in calcium from mouse rods with fluorescent dyes. Findings have implicated both increases and decreases in calcium concentration as contributing factors in the triggering of apoptosis. Such information may provide insight into the mechanisms of retinal degeneration.

Faculty | Stein Eye Institute 39 Public Service Debora B. Farber, PhD, DPhhc Scientific Advisory Board Member, the Foundation Fighting Blindness; the Center for Vision Research, State Karl Kirchgessner Foundation Chair in Vision Science University of New York at Syracuse; the Vision of Children Foundation; and Distinguished Professor of Ophthalmology an Advisor for the Canadian Retinitis Member of the Brain Research Institute Pigmentosa Foundation Editorial Board Member, Molecular Member of the Molecular Biology Institute Vision; The Open Ophthalmology Member of the Stein Eye Institute Journal; Journal of Ocular Biology, Diseases, and Informatics; and Stem Cells and Cloning Advances and Applications Reviewer for many scientific journals RESEARCH SUMMARY Retinal Biochemistry, Molecular Biology, and Genetics of Retinal Degenerations

Dr. Farber’s research focuses on the isolation and characterization of genes involved in inherited retinal diseases. Her team has cloned several genes encoding enzymes and proteins that play a key role in vision, including the α-PDE gene, that leads to blindness in mice and dogs, and causes one type of autosomal recessive retinitis pigmentosa (arRP) (utilizing gene therapy methods, they rescued mice photoreceptors by delivering the normal gene to these cells); RP1 (responsible for a type of autosomal dominant RP); the gene causing disease in the rd7 mouse—a model for Enhanced S-Cone Syndrome; the α-transducin gene, disrupted in the Rd4 mouse, another model of retinal disease; and the mouse homologue of the gene causing X-linked juvenile retinochisis (Xlrs1). Dr. Farber’s group is also working on the mechanisms that regulate transcription and expression of retinal genes. They found that the transcription factor SP4 controls the activity of the α-PDE promoter and that mutations in both SP4 and α-transducin cause digenic arRP and cone-rod dystrophy (arCRD). Other projects include the identification of cone genes (mutations in 7R and ZBED4 cause arRP and arCRD); the characterization of animal models of ocular albinism, which are affected with permanent visual impairment; and the study of microvesicles released by mouse embryonic stem cells that transfer RNA or protein to other cells, in vitro.

40 Stein Eye Institute | Faculty Public Service JoAnn A. Giaconi, MD Member, Glaucoma Panel, American Academy of Ophthalmology Knowledge Base Development Project Health Sciences Associate Professor of Ophthalmology Faculty, Glaucoma section of American Chief of the Ophthalmology Section at the Greater Los Angeles Academy of Ophthalmology’s VA Healthcare System Basic and Clinical Science Course Co-Director of Medical Student Education at the Member, Surgical Advisory Board for David Geffen School of Medicine, UCLA National Veterans Affairs Vice President of Membership, Member of the Stein Eye Institute Women in Ophthalmology Councilor, California Academy of Eye Physicians and Surgeons RESEARCH SUMMARY Past President, Los Angeles Society Glaucoma of Ophthalmology Volunteer, Eye Care America Dr. Giaconi’s research focuses on the Reviewer for many scientific journals treatment of glaucoma and the effects of glaucoma surgery on the cornea and vision. She is currently working on a project examining the overtreat- ment or undertreatment of glaucoma in the veteran population. She is also enrolling patients in two clinical studies at the Stein Eye Institute. One study is examining the effect of various glaucoma surgeries on the corneal endothelium, which is the layer of cells that keeps the cornea clear, and the other is investigating the postoperative eye pressure course following Ahmed valve implant surgery.

Faculty | Stein Eye Institute 41 Research Grants Ben J. Glasgow, MD National Eye Institute: Proteins in the Molecular Mechanisms of Tear Film Formation, 9/1/11–8/31/16 Edith and Lew Wasserman Professor of Ophthalmology Professor of Pathology and Laboratory Medicine Chief of the Ophthalmic Pathology Division Member of the Stein Eye Institute

RESEARCH SUMMARY Ophthalmic Pathology

Dr. Glasgow’s research interests are primarily in the field of ophthalmic pathology. His major focus is the role of human lacrimal gland proteins in the protection and maintenance of the eye. His laboratory is investigating the structure-function relationship of tear lipocalin, the principal lipid carrier protein of tears. Currently, the laboratory has developed a technique called site-directed tryptophan fluorescence to probe and report information re- garding molecular motion and solution structure. By studying the molecular mechanisms of tear proteins, Dr. Glasgow is seeking to learn the normal functions of tear lipocalin and its role in maintaining the health of the ocular surface and in the prevention of dry eye diseases. It is hoped that this research will lead to new treatments for dry eye and have broad application to numerous other members of this protein family that transport small, in- soluble molecules through the body.

42 Stein Eye Institute | Faculty Public Service Robert Alan Goldberg, MD Vice President, American Society of Ophthalmic Plastic and Reconstructive Surgery Karen and Frank Dabby Endowed Chair in Ophthalmology Assistant Vice President Professor of Ophthalmology of Professional Education, California Academy of Ophthalmology Chief of the Orbital and Ophthalmic Plastic Surgery Division Fellow and Chair, International Director of the UCLA Orbital Disease Center Committee, American Society of Ophthalmic Plastic and Co-Director of the UCLA Aesthetic Center Reconstructive Surgeons Member of the Stein Eye Institute Fellowship Program Director, American Academy of Cosmetic Surgery and American Society of Ophthalmic Plastic and Reconstructive Surgery

RESEARCH SUMMARY Editorial Board Member, Archives of Ophthalmology, Ophthalmic Plastic Diseases and Therapy of the Eyelid and Orbit and Reconstructive Surgery, Aesthetic Surgery Journal, and Archives of Facial Plastic Surgery Research into the various surgical Outcomes of medical and surgical Section Editor, American Academy of approaches to Graves orbitopathy treatment of orbital and eyelid dis Ophthalmology, ONE Network (thyroid eye disease) has resulted orders are being studied in an orga- in new techniques that include less nized, prospective fashion in order to invasive small incision surgical ap- better understand which treatments proaches. In addition, detailed clinical are most effective. information gathered from patients with Graves orbitopathy is being re- corded in a shared database as a way to understand the natural history and response to treatment of this multifaceted disease, which is a cause of significant visual loss and discomfort. Multicenter studies are underway. Dr. Goldberg is also investigating the underlying causes of thyroid-related orbitopathy. The goal of this research is to develop better tests to monitor disease activity, as well as new treatments to address the basic cause of the disease. Research into orbital and eyelid anatomy, currently in progress, is resulting in improved techniques and approaches to deep orbital disease. Included is the use of high-resolution magnetic resonance imaging and high-resolution dynamic ultrasonography to evaluate motility problems following trauma and orbital surgery, and three-dimensional analysis of orbital anatomy. Improved understanding of eyelid and orbital anatomy is the basis for developing improved surgical techniques. Instru- mentation and devices that allow less invasive surgical approaches, such as hyaluronic acid gels, are being developed and studied. In collaboration with the Department of Engineering, custom materials for orbital reconstruction are investigated.

Faculty | Stein Eye Institute 43 Honors Lynn K. Gordon, MD, PhD Received the David Geffen School of Medicine Excellence in Education Award on May 20, 2014, at UCLA, for Vernon O. Underwood Family Chair in Ophthalmology leadership and commitment to medical school education. Professor of Ophthalmology Senior Associate Dean for Academic Diversity, Public Service David Geffen School of Medicine at UCLA Member, Dermatologic and Ophthalmic Drugs Advisory Committee, Federal Chair of the College of Applied Anatomy, Drug Administration David Geffen School of Medicine at UCLA Member, Scientific Review Committee, Member of the Stein Eye Institute Fight for Sight Committee Member, American Academy of Ophthalmology, Basic and Clinical Science Course Section 5, Neuroscience RESEARCH SUMMARY Councilor, American Academy of Ophthalmology Retinal Cell Biology and Inflammatory Disease Member, Association for Research in Vision and Ophthalmology’s Dr. Gordon’s laboratory is involved in important role in immune regulation WEAVR Committee two primary areas of research. One in retinal formation. PD-1 has a major Chair, Neuro-Ophthalmology Research project investigates the role for epi- function as a negative regulator in the Committee, Member of the Board, North American Neuro-Ophthalmology thelial membrane protein 2 (EMP2) in immune system. Although previous Society controlling ocular pathologic respons- studies identified PD-1 expression in President, California Academy of es. Dr. Gordon and her colleagues the lymphoid system, Dr. Gordon and Eye Physicians and Surgeons identified that EMP2 plays an impor her colleagues have recently identi- Editorial Board Member, Investigative tant role in an in vitro model of pro- fied its expression in neuronal cells Ophthalmology and Visual Science, liferative vitreoretinopathy (PVR) and of the retina. This observation raises Journal of Neuro-Ophthalmology, and have evidence that EMP2 is highly ex- the possibility of a developmental Ocular Immunology and Inflammation pressed in human retinal diseases. In role for PD-1 in maturation of the addition, they recently identified that ganglion cell layer and retinal remod- Research Grants EMP2 controls VEGF production in eling process as well as a possible National Eye Institute: Novel Therapies to Prevent Blindness Caused by epithelial cells and in specific tumors. role for PD-1 in degenerative neuronal Proliferative Vitreoretinopathy, The laboratory, in collaboration with diseases. By understanding the role of 4/1/10–3/31/15 others at UCLA, has recently devel- PD-1 in the retina, we may understand Quark Pharmaceuticals, Inc.: A Phase I oped a designer antibody fragment how to improve the visual outcome for Open Label, Dose Escalation Trial that has demonstrated efficacy in patients with optic nerve diseases. of QPI-1007 Delivered by a Single Intravitreal Injection to Patients with in-vitro studies in the PVR model and Optic Nerve Atrophy (Stratum I), in other animal models in vivo. This 3/17/10–3/16/15 antibody has now been successfully used to control pathologic neovascularization in a corneal burn model, achieving proof of principal for using this antibody to control disease. The second area of interest of Dr. Gordon’s group is the developmental role of programmed death 1 (PD-1), a molecule that is known to play an

44 Stein Eye Institute | Faculty Public Service Michael B. Gorin, MD, PhD Medical Director, Stein Eye Institute’s Electronic Medical Record System

Harold and Pauline Price Chair in Ophthalmology Member, Medical Education Committee, David Geffen School of Professor of Ophthalmology Medicine at UCLA Professor of Human Genetics Editorial Board Member, Current Eye Research and Chief of the Division of Retinal Disorders and Ophthalmic Genetics Experimental Eye Research Member of the Stein Eye Institute Advisory Board Member, American Health Assistance Foundation Member, Association of University Professors of Ophthalmology, Consortium of Medical RESEARCH SUMMARY Education Directors Hereditable Eye Disorders and Molecular Genetics Member, Special National Institutes of Health Study Sections for the National of Age-Related Maculopathy Eye Institute, National Institute on Aging (Claude Pepper Grants), National Dr. Gorin’s primary research focus work, opportunities have emerged to Human Genome Research, Center for Inherited Disease Research is molecular genetics of hereditable investigate the pathogenesis of light eye disorders, specifically age-related sensitivity for individuals who suffer Scientific Advisory Committee Member, the American Health macular degeneration (AMD). His re- from migraines and/or mild traumatic Assistance Foundation and the Knights search group was the first to identify brain injury. Templar Eye Research Foundation specific regions of the genome that Clinical research efforts are directed Founding Member of the contributed to ARM development in von Hippel-Lindau Center of Excellence families, leading to discovery of gene towards developing methods to moni at UCLA Medical Center tor and quantify retinal function in pro- variations that contribute to the risk Member of the Clinical Research of developing ARM. He continues to gressive retinal disorders (such as di- Governance Committee for UCLA abetic retinopathy, Stargardt disease, work on studies of the genetics of Reviewer for many scientific journals AMD, in particular the use of genetic and retinitis pigmentosa) and in pa- risk profiles to test for clinical mark- tients with potential ocular toxicities Research Grants ers, including sensitive methods for from systemic medications. Applied National Eye Institute: Genetics detecting changes in retinal structure research interests include bioinformat- of Age-Related Maculopathy, 4/1/07–3/31/14 and function that precede the onset ics in clinical ophthalmic practice and of clinical disease. public health issues pertaining to oc- Neuro Kinetics, Inc.: Phase 2- ular disease. Developing a Noninvasive Method and Device for Assessing the Degree of Dr. Gorin investigates the molecular Midperipheral Retinal Ischemia in genetics of complex disorders such as Diabetic Retinopathy, 2/1/11–1/31/14 cystoid macular edema, age-related cataracts, and glaucoma, as well as monogenic disorders such as hereditary retinal degenerations, glaucoma, cataracts, and ocular syndromes. He is pursuing studies to identify genetic variations that contribute to the severity, complications, and therapeu tic responses of these conditions. Dr. Gorin and his clinical team work with the clinical and research human genetics group at UCLA to explore use of new technologies, including next-generation sequencing for clinical utility in ophthalmic genetics. Research also focuses on the neurobiology of ocular pain and photophobia (sensitivity to light) to understand the basic biology and neural pathways that contribute to photophobia so that new therapeutic strategies can be developed. Based upon preliminary

Faculty | Stein Eye Institute 45 Public Service David Rex Hamilton, MD, FACS Editorial Board Member, Ophthalmology, Journal of Refractive Surgery, and Journal of Cataract and Health Sciences Associate Professor of Ophthalmology Refractive Surgery Director of the UCLA Laser Refractive Center Member, Refractive Leadership Council, Alcon Laboratories Member of the Stein Eye Institute Member, ASCRS Refractive Surgery Clinical Committee Member, ASCRS Refractive Surgery/ Cataract Clinical Subcommittee RESEARCH SUMMARY Member, American Academy Advanced Intraocular Lenses of Ophthalmology, Preferred Practice Pattern Committee for Refractive Surgery Dr. Hamilton’s research interests are Member, American Academy of in the areas of corneal biomechanics Ophthalmology, ONE Network, and tomography (3D imaging of the Refractive Surgery cornea), screening for corneal ectatic disorders, and the clinical study of intraocular lenses (IOLs) for the treatment of high myopia (phakic IOLs), astigmatism (toric IOLs), and presbyopia (multifocal and accommodating IOLs). Dr. Hamilton is actively involved in training residents and fellows in the surgical treatment of refractive errors and cataracts.

46 Stein Eye Institute | Faculty Honors Gary N. Holland, MD Named a Gold Fellow by the Association for Research in Vision and Jack H. Skirball Chair in Ocular Inflammatory Diseases Ophthalmology (ARVO), May 2014.

Professor of Ophthalmology Public Service Director of the Ocular Inflammatory Disease Center Associate Editor, American Journal of Ophthalmology Director of the UCLA Department of Ophthalmology Clinical Research Center Executive Committee Member, Co-Director of Medical Student Education American Uveitis Society at the David Geffen School of Medicine, UCLA Steering Committee Member, Studies Member of the Stein Eye Institute of the Ocular Complications of AIDS Steering Committee Member, RESEARCH SUMMARY Zoster Eye Disease Study International Council Member, Uveitis and Cornea-External Ocular Diseases International Ocular Inflammation Society Dr. Holland’s research interests in- individuals, even among those whose volve infectious and inflammatory dis- immune function has improved be- Research Grants eases of the eye. A major focus of cur- cause of antiretroviral drugs. In addition, Advanced Cell Technology, Inc.: ARO rent research is ocular toxoplasmosis, he is investigating abnormalities of reti- Agreement A Phase I/II, Open-Label, Multicenter, Prospective Study to the most common retinal infection nal blood vessels and abnormal blood Determine the Safety and Tolerability in the general population. Dr. Holland flow as possible contributing factors of Subretinal Transplantation… is conducting various epidemiological for development of NRD. Studies per- Patients with Stargardt Macular and laboratory investigations in col- formed by Dr. Holland have shown that Dystrophy SMD, 4/25/11–12/12/16 laboration with investigators at the these vascular changes are markers of Advanced Cell Technology, Inc.: ARO Agreement A Phase I/II, Open-Label, National Institutes of Health, the U.S. non-ocular, sometimes life-threatening, Multicenter, Prospective Study to Centers for Disease Control and Pre- diseases among people with AIDS. Determine the Safety and Tolerability vention, and other universities in the of Subretinal Transplantation… United States, Brazil, and Europe, to In conjunction with members of the Patients with Advanced Dry AMD, 5/31/11–12/12/16 understand the sources of infection, Department of Pediatrics–Rheuma- course of disease, response to treat- tology Division, Dr. Holland has es- Advanced Cell Technology, Inc.: Monitoring of a Phase I/II, Open-Label, ment, and disease outcomes. Patient tablished a program to provide care for children with chronic anterior Prospective Study to Determine the genetic and parasite-related factors Safety and Tolerability of Subretinal that influence the risk of ocular in- uveitis, a common feature of juvenile Transplantation …Patients with volvement are being studied. idiopathic arthritis (JIA). He is inves- Geographic Atrophy Secondary to tigating risk factors for development Myopic Macular Degeneration, Since 1981, Dr. Holland has been in- of vision-threatening complications 3/31/14–3/31/16 volved in the study of HIV-related eye of JIA-associated uveitis and study- Xoma (US) LLC: A Randomized, Double-Masked, Placebo-Controlled disease. He has participated in a large, ing the most effective techniques for Study of the Safety and Efficacy of NIH-supported multicenter study to evaluation and treatment of affected Gevokizumab in the Treatment of investigate how the ocular manifes- children. Subjects with Non-Infectious tations of HIV disease have changed Intermediate Posterior or Panuveitis Currently Controlled with Systemic since the introduction of potent anti Dr. Holland is also investigating birdshot chorioretinopathy, a chronic auto Treatment Protocol #X052131, retroviral drugs. In particular, he is 1/8/13–11/25/14 using data generated in the study to immune disease of the eye, in conjunction with Drs. Ralph D. Levinson, Xoma (US) LLC: A Randomized investigate HIV-related “neuroretinal Double-Masked, Placebo-Controlled disorder” (NRD), a degenerative con- Steven Nusinowitz, and researchers Study of the Safety and Efficacy of dition of the retina that appears to be from Service d’Ophtalmologie, Hôpi- Gevokizumab in the Treatment of tal Cochin, Université Paris, France. Active Noninfectious Intermediate the cause of subtle changes in vision Posterior or Panuveitis, 1/8/13–11/25/14 that are known to occur in HIV-infected John Hopkins University: Multicenter Uveitis Steroid Treatment (MUST) Trial, 6/1/12–4/30/15 John Hopkins University: Studies of Ocular Complications of AIDS (SOCA), 8/1/13–7/31/14 National Eye Institute: UCLA/AUPO Introduction to Clinical Research Course, 5/1/12–4/30/14

Faculty | Stein Eye Institute 47 Research Grants Joseph Horwitz, PhD National Eye Institute: Analysis of Lens Crystallins and Cataractous Mutants at High Hydrostatic Pressure, Oppenheimer Brothers Chair 4/1/14–3/31/19 Distinguished Professor of Ophthalmology Member of the Stein Eye Institute

RESEARCH SUMMARY Biochemistry and Biophysics of the Crystalline Lens

Dr. Horwitz is conducting research on the biochemical and biophysical properties of normal and cataractous lens proteins. In addition, he is investigating the molecular chaperone properties of the lens’ alpha-crystallin, a protein that plays an important role in keeping the eye lens clear during normal aging. Alpha-crystallin is also involved in age-related macular degeneration, as well as in many other neurodegenerative diseases. New spectroscopical techniques are currently being developed for studying protein function and structure utilizing extremely high hydrostatic pressure.

48 Stein Eye Institute | Faculty Honors Wayne L. Hubbell, PhD In recognition of influential and distinguished contributions to the practice of electron paramagnetic Jules Stein Chair in Ophthalmology resonance (EPR)/electron spin resonance (ESR) spectroscopy, and Distinguished Professor of Ophthalmology its welfare over a long period, selected Distinguished Professor of Chemistry and Biochemistry as a 2014 Fellow of the International EPR (ESR) Society. Co-Chief of the Vision Science Division Public Service Associate Director of the Stein Eye Institute Member, National Academy of Sciences Member, American Academy of RESEARCH SUMMARY Arts and Sciences Molecular Basis of Phototransduction Research Grants in the Vertebrate Retina National Eye Institute: Molecular Basis of Membrane Excitation, 5/1/10–4/30/15 Dr. Hubbell’s research is focused highlighted a crucial role for protein National Eye Institute: Core Grant on understanding the complex rela flexibility (dynamics), which has not for Vision Research at the tionship between molecular struc- been previously appreciated. To ex- Stein Eye Institute, 3/1/10–2/28/15 ture, plasticity, and conformational plore molecular flexibility in proteins of University of San Diego: Molecular changes that control protein function the visual system, Dr. Hubbell’s group Basis of Selective P450 3A Function, in the visual system. Of particular is developing novel methods using 3/1/11–2/28/14 interest are proteins that behave as time-domain and high-pressure EPR. “molecular switches,” that is proteins whose structures are switched to an active state by a physical or chemical signal. Examples include rhodopsin, the membrane-bound photoreceptor protein of the retina, and transducin and arrestin, proteins that associate with rhodopsin during function. The overall goal is to determine the structure of these proteins in their native environment, monitor the changes in structure that accompany the tran- sition to an active state, and to understand the role of protein flexibility in function. To investigate these and other proteins, Dr. Hubbell’s laboratory has developed the technique of site-directed spin labeling, a novel and powerful approach to the exploration of protein structure and dynamics. By changing the genetic code, a specific attachment point in the protein is created for a nitroxide spin label probe. Analysis of the electron paramagnetic resonance (EPR) spectrum of the spin label provides information about the local environment in the protein. With a sufficiently large set of labeled proteins, global information on structure is obtained and changes in the structure during function can be followed in real time. While determination of static protein structure is important to understanding function, current research has

Faculty | Stein Eye Institute 49 Public Service Jean-Pierre Hubschman, MD Reviewer for many scientific journals

Research Grants Assistant Professor of Ophthalmology Ophthotech Corporation: A Phase3, Member of the Stein Eye Institute RDM, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Administration of Fovista (Anti PDGF-B Pegylated Apramer) Administered… ARMD, 12/4/13–12/3/15 RESEARCH SUMMARY Advanced Vitreoretinal Surgical Interventions and Robotics

Dr. Hubschman’s clinical research focuses on the development and evaluation of new vitreoretinal surgical techniques and robotics for ophthalmic surgery. Automated surgery utilizing robotics promises to increase surgical precision and accuracy, and improve access to medical care. His publications include research papers as well as a book chapter about the feasibility of robotic surgery in ophthalmology. Currently, he is also investigating the use of the terahertz laser for the evaluation of ocular tissue hydration.

50 Stein Eye Institute | Faculty Honors Sherwin J. Isenberg, MD Delivered the Presidential Lecture, Combatting Pediatric Blindness in the 21st Century, at the All India Laraine and David Gerber Chair in Ophthalmology Ophthalmological Conference on February 6, 2014, in Agra, India. Professor of Ophthalmology Professor of Pediatrics Public Service President, American Association Vice-Chairman of the UCLA Department of Ophthalmology for Pediatric Ophthalmology Member of the Stein Eye Institute and Strabismus Member, Medical Advisory Board and Board of Directors; and Research Committee Chair, RESEARCH SUMMARY Blind Children’s Center Past President, Costenbader Pediatric Ophthalmology, Amblyopia, and Pediatric Ophthalmology Society Ophthalmic Pharmacology Co-Founder and Delegate, International Pediatric Ophthalmology and Strabismus Council Dr. Isenberg’s research activities have of the eye, which blind approximate- concentrated on various aspects of ly 10,000 children annually, has been surgical and medical diseases of chil- completed at three sites in India. dren’s eyes. The goal is to decrease the frequency of blindness in children Lastly, a new device that reports blood worldwide. In a series of studies of gases from the conjunctiva, such as newborns, Dr. Isenberg has charac- oxygen and carbon dioxide, is being de- terized a number of elements, includ- veloped. Preliminary trials have been ing: the type and source of bacteria completed in animals and in adults un- of the external eye at birth; the evo- dergoing cardiac bypass surgery. The lution of iris structural changes; the hope is to apply the device to the eyes development of the macula, which of premature newborns. The continu- is the source of central vision; and ous readout of tissue blood gas levels pupillary responses after birth. Re- should enable the pediatrician to pre- cent publications have characterized vent damage to the baby’s brain and the production and nature of tears of keep the oxygen at an appropriate lev- infants and the development of the el, minimizing the possibility of blind- cornea in the first year of life. He has ness from retinopathy of prematurity. also reported the ocular signs in newborns whose mothers abuse cocaine, facilitating the diagnosis of newborn cocaine intoxication. In another avenue of research, povidone-iodine eyedrops have been found to treat bacterial conjunctivitis successfully in a three-year, international study with the University of the Philippines. The eyedrops were also found to be safer and more effective in preventing eye infections than the currently used agents. Dr. Isenberg and other investigators have now proven that the povidone-iodine eyedrops can treat the number one cause of preventable pediatric blindness in the world––corneal infections due to bacteria. These studies, conducted in children and adults in India and the Philippines, should reduce the number of 400,000 children now blind from corneal infections. A new study investigating fungal infections

Faculty | Stein Eye Institute 51 Public Service Simon K. Law, MD, PharmD Expert Reviewer, Medical Board of California

Health Sciences Clinical Professor of Ophthalmology Pharmacy Editor, eMedicine online Ophthalmology Journal Member of the Stein Eye Institute Member of the Committee on Aging, American Academy of Ophthalmology Subcommittee Member, American Academy of Ophthalmology Basic and RESEARCH SUMMARY Clinical Science Course Optic Disc Evaluation Reviewer for many scientific journals

Dr. Law’s principal research interest Glaucoma Tube Shunt Procedure focuses on the structural appearance To prevent intraocular pressure spikes of the optic disc in different ocular after an Ahmed valve or tube shunt diseases, including patients with high procedure for glaucoma, Dr. Law is myopia. Assessment of optic disc size evaluating the effect of using anti- is an important component of the di- glaucoma medications at different agnostic evaluation for glaucoma. Pa- times following surgery. Patients are tients with high myopia are at greater randomized to receive antiglaucoma risk of developing glaucoma, and they medications either at an early phase also have an atypical optic disc that or at the standard time following the makes diagnosis difficult. The purpose surgical procedure. of Dr. Law’s research is to characterize the appearance of the optic disc in Acupuncture and Glaucoma eyes with high myopia and to identify Dr. Law is conducting a prospective the related risk factors for develop- study to evaluate the effect of acu- ment of glaucoma. puncture in glaucoma. Acupuncture is a popular alternative medicine based on traditional Eastern medical theory. Its effect on glaucoma has not been objectively and scientifically studied.

52 Stein Eye Institute | Faculty Public Service Ralph D. Levinson, MD Member, COMPASS, ONE, BCSC Committees, American Academy of Ophthalmology Health Sciences Clinical Professor of Ophthalmology Member, Knowledge-Based Uveitis Member of the Stein Eye Institute Panel, American Academy of Ophthalmology Practicing Ophthalmologists Curriculum Reviewing Editor, Ocular Immunology and Inflammation RESEARCH SUMMARY Institutional Review Board Member, Ocular Inflammatory Diseases UCLA Reviewer for many scientific journals Dr. Levinson’s research interest is ocular inflammatory diseases. He is the Research Grants primary investigator on international MacDonald Family Foundation: research projects in both the clinical Immunologic and Clinical Studies of Eye Disease at the Stein Eye Institute, aspects of uveitis and the basic mech- 12/1/08–12/1/14 anisms and immunogenetics of ocular inflammation. Current projects include a collaborative longitudinal study of a chronic inflammatory disease, birdshot chorioretinopathy, with investigators in France. The study focuses on the inter- relationship of disease factors, as well as the course of disease and response to treatment. Dr. Levinson is also conducting laboratory research on cell-based therapies for uveitis.

Faculty | Stein Eye Institute 53 Public Service Colin A. McCannel, MD Moderator, “Retina Talk” online discussion forum, American Association of Retina Specialists Professor of Clinical Ophthalmology Judge, American Society of Retina Member of the Stein Eye Institute Specialists 14th Annual Film Festival Chair, Editorial Committee, Retina and Vitreous Basic and Clinical Science Course, Section 12, American Academy of Ophthalmology RESEARCH SUMMARY Medical Information Technology Vitreoretinal Surgery Committee Member, American Academy of Ophthalmology Dr. McCannel has a longstanding interest in the management of vitreoretinal Instruction course grader for the 2013 Annual Meeting, Annual Meeting conditions, particularly complex retinal detachments, complications of diabetic Program Committee, American retinopathy, macular holes and epimacular membranes, and age-related macu- Academy of Ophthalmology lar degeneration. His clinical research efforts are directed at the improvement Abstract grader for the 2013 Annual of vitreoretinal surgical techniques and outcomes, including the prevention of Meeting, Annual Meeting Program endophthalmitis following intravitreal injections. Committee, American Academy of Ophthalmology Dr. McCannel devotes time to educational research as well. Currently, he is in- Reviewer for many scientific journals vestigating the utility of virtual reality surgery simulation in teaching ophthalmic surgery. He has several ongoing protocols that assess ophthalmic surgical simulation in surgical teaching.

54 Stein Eye Institute | Faculty Public Service Tara A. McCannel, MD, PhD Reviewer for many scientific journals

Health Sciences Associate Professor of Ophthalmology Director of the Ophthalmic Oncology Center Member of the Stein Eye Institute

RESEARCH SUMMARY Metastatic Ocular Melanoma

Dr. McCannel’s primary research in- Health Psychology and terest is metastatic ocular melanoma. Ocular Melanoma Under her direction, the Ophthalmic Central to incorporating an integra- Oncology Laboratory is studying mo- tive approach to health care, the lecular markers in ocular melanoma to concerns and wishes of the patient provide prognostic information to pa- as a whole are important aspects of tients and advance understanding of cancer management. In collaboration metastatic disease. Discovery of can- with the UCLA Department of Health didate genes from tissue of patients Psychology and the Jonsson Compre- undergoing surgical treatment for oc- hensive Cancer Center, Dr. McCannel ular melanoma is being explored. This works closely with health psycholo- information will be important to estab- gists who are interested in providing lish a better understanding of the bi- clinical care while researching factors, ology of metastatic ocular melanoma which predict psychological adjust- and help develop better treatments ment to cancer. for this cancer. New modalities are being investigated to predict, detect, and ultimately treat choroidal mela noma metastasis.

Surgical Approaches to Vitreoretinal Disease and Cancer Dr. McCannel is both a vitreoretinal surgeon and an ophthalmic oncologist. She manages the spectrum of vitreoretinal disease in addition to the surgical management of ocular melanoma, allowing patients to benefit maximally from her wide range of surgical prognostic and therapeutic expertise. Vitrectomy with silicone oil placement is a novel therapeutic strategy, which was discovered at UCLA to reduce radiation exposure to the healthy structures of the eye during plaque surgery for melanoma treatment. Dr. McCan- nel offers this potentially sight-saving technique to patients who need radiation treatment.

Faculty | Stein Eye Institute 55 Public Service Kevin M. Miller, MD Course Director, Southern California Basic and Advanced Cataract Surgery Courses for Residents Kolokotrones Chair in Ophthalmology and Fellows Professor of Clinical Ophthalmology American Academy of Ophthalmology, Skills Transfer Course Chief of the Comprehensive Ophthalmology Division Advisory Committee Member of the Stein Eye Institute American Academy of Ophthalmology, Annual Meeting Program Committee, Cataract Subcommittee American Society of Cataract RESEARCH SUMMARY and Refractive Surgery, Retina Clinical Committee Cataract and Refractive Surgery World Congress of Ophthalmology 2014 Biannual Meeting Program Planning Committee, Cataract Section Dr. Miller’s research interests are in cataract surgery, he also performs cataract and refractive surgery, intra- DSEK, LASIK, and other cornea-based American Society of Cataract and Refractive Surgery ocular lenses, artificial iris implants, laser refractive procedures. Skills Transfer Subcommittee ophthalmic optics, surgical devices, Faculty of 1000, Post-Publication and surgical outcomes. Dr. Miller runs several clinical trials of artificial iris implants to treat congeni- Peer Review, Lens Disorders Section Dr. Miller’s clinical practice focuses tal and acquired aniridia. He completed International Editorial Board, primarily on refractive cataract sur- the multicenter Ophtec 311 clinical trial. Oftalmologia Em Foco gery and the surgical correction of He has an individual device exemption Column Editor, American Society of presbyopia and astigmatism with pre- from the FDA to study Morcher GmbH Cataract and Refractive Surgery, EyeWorld Magazine mium technology intraocular lenses. artificial iris implants. He is the only sur- He developed an astigmatism man- geon in the United States who is per- Editorial Board, Cataract and Refractive Surgery Today agement service for treating corneal mitted by the FDA to implant Morcher astigmatism at the time of cataract devices at this time. He is also study- Editorial Board, American Academy of Ophthalmology, EyeNet Magazine surgery that optimizes postoperative ing a custom artificial iris implant from uncorrected visual acuity. He de- Dr. Schmidt Intraocularlinsen, a subsid- Reviewer for many scientific journals veloped a nomogram for peripheral iary of HumanOptics AG. All of these Research Grants corneal relaxing incisions and partici- devices are showing promising results Alcon Laboratories, Inc.: Post Approval pated in the clinical trial of the world’s in patients who suffer from congenital Study of the Acrysof IQ Toric High most popular toric intraocular lens. and acquired iris defects. Cylinder Power Intraocular Lens (IOL), He described a nonparametric multi- 4/17/12–1/21/15 He is also an investigator in the Cal- variate technique for comparing astig- Calhoun Vision, Inc.: A Prospective matism outcomes between treat- houn Vision light adjustable lens study Randomized Controlled Multicenter ment groups. In addition to refractive and the Alcon high-power toric lens Clinical Study to Evaluate the Safety post-market approval study. and Effectiveness of the Light Adjustable Lens, 7/26/12–12/10/14 Clinical Research Consultants, Inc.: Safety and Effectiveness of the Customflex Artificial Iris Prosthesis for the Treatment of Iris Defects (Al-001), 6/12/14–6/14/16

56 Stein Eye Institute | Faculty Honors Bartly J. Mondino, MD Recognized by the Association of University Professors of Ophthalmology on January 30, 2014, Bradley R. Straatsma, MD Endowed Chair in Ophthalmology in Miami, Florida, for ten years of service to the organization as its Distinguished Professor of Ophthalmology executive vice president. Chairman of the UCLA Department of Ophthalmology Presented the Doheny Lecture, Corneal Ulcers, on June 20, 2014, Member of the UCLA Brain Research Institute at the Doheny Eye Institute in Director of the Stein Eye Institute Los Angeles, California.

Public Service Medical Advisory Board Member, RESEARCH SUMMARY Braille Institute Board of Trustees Member, Cornea and External Ocular Diseases and Association of University Professors Immunological Disorders of Ophthalmology Executive Vice-President, Association of University Professors Dr. Mondino’s research activity is focused on cornea-external ocular diseases, of Ophthalmology with particular emphasis on immunological disorders. He has studied the role of Editorial Board Member, Ophthalmic lymphocytes and the complement system in the immunopathogenesis of anterior Surgery, Lasers and Imaging segment diseases. In addition, a model of staphylococcal hypersensitivity lesions Editor, Association of University of the cornea was explored as well as the immune response to staphylococcal Professors of Ophthalmology, endophthalmitis. Other research interests included corneal dystrophies, peripheral News & Views corneal ulcers, bullous diseases of the skin and mucous membranes, collagen Board of Directors Member, National shields, and contact lens-related corneal ulcers. Alliance for Eye and Vision Research

Research Grants Research to Prevent Blindness: Departmental Unrestricted Grant Award (Annual), 1/1/12–12/31/14

Faculty | Stein Eye Institute 57 Public Service Kouros Nouri-Mahdavi, MD, MSc Member, American Academy of Ophthalmology Glaucoma Registry Measures Working Group Assistant Professor of Ophthalmology Member, American Glaucoma Society Member of the Stein Eye Institute Patient Care Committee, Document Subcommittee Glaucoma Section Editor, Journal of Vision and Eye Research RESEARCH SUMMARY Member, Residency Program Evaluation Committee Role of Structural and Functional Measurements for Member, Stein Eye Institute Detection of Glaucoma and Its Progression Electronic Medical Record Implementation Committee Dr. Nouri-Mahdavi’s research is fo- Member, Research Committee, American Glaucoma Society cused on improving methods to detect early glaucoma and glaucoma Volunteer for EyeCare America progression with spectral-domain op- Editorial Board Member, Journal of tical coherence tomography (SD-OCT) Ophthalmic and Vision Research and various perimetry techniques. Reviewer for many scientific journals More specifically, he is interested in detection of glaucoma progression Research Grants in patients with advanced disease. National Eye Institute: Detection of SD‑OCT has revolutionized glaucoma Glaucoma Progression with Macular OCT Imaging, 7/1/12–6/30/17 imaging. Dr. Nouri-Mahdavi is currently exploring the role of macular imaging for detection of glaucoma progression. He is also interested in exploring the structure-function relationships in eyes with angle-closure glaucoma versus eyes with primary open-angle glaucoma. Three cross-sectional and longitudinal SD-OCT imaging studies enrolling open-angle and angle-closure glaucoma patients along with normal control subjects are ongoing in the Glaucoma Division.

58 Stein Eye Institute | Faculty Public Service Steven Nusinowitz, PhD Editorial Board Service, Current Eye Research

Associate Professor of Ophthalmology Grant Reviewer: Foundation Fighting Blindness, Medical Research Council Co-Director of the Visual Physiology Laboratory of Canada, Wellcome Trust, Matilda Zeigler Foundation, and Director of the Live Imaging and Functional Evaluation (LIFE) Core National Eye Institute (ad hoc) Member of the Stein Eye Institute Scientific Advisor: The Mouse Mutant Resource, The Jackson Laboratory; Novartis Pharmaceuticals; Allergan, Inc.; and Isis Pharmaceuticals, Inc.

RESEARCH SUMMARY Data Safety Management: New Drug Investigations, Mechanisms of Retinal Degeneration Isis Pharmaceuticals, Inc. Reviewer for many scientific journals Dr. Nusinowitz’s primary research interest is focused on understanding the cellular contributions to noninvasive measures of visual function and defining the sites and mechanisms of disease action in inherited retinal and visual pathway disorders. His main approach to gaining an understanding of the site and underlying mechanism of disease action in humans is to study the patterns of electrophysiological and psychophysical responses obtained from mice in which the disruption of different cells or pathways in the visual system are specifically targeted by genetic manipulation. By comparing the patterns of responses in human disease with the patterns of responses from rodents with targeted cellular disruption, Dr. Nusinowitz is able to test hypotheses about the underlying pathophysiology in human disease and to provide a mechanism for the development of specific diagnostic tools that are sufficiently sensitive for early detection and better diagnosis of clinical disease.

Faculty | Stein Eye Institute 59 Public Service Stacy L. Pineles, MD Member, Department of Ophthalmology Residency Training Committee and Department of Assistant Professor of Ophthalmology Ophthalmology Residency Selection Committee Member of the Stein Eye Institute Associate Residency Director, Department of Ophthalmology Member, Research Committee, RESEARCH SUMMARY American Academy of Pediatric Ophthalmology and Strabismus Pediatric Neuro-Ophthalmology and Member, Professional Education Neurologic Causes of Strabismus Committee, American Academy of Pediatric Ophthalmology and Strabismus Dr. Pineles’ research interests include Member, Young Neuro- evaluating the surgical outcomes of Ophthalmologists Committee, strabismus surgery and studying pe- North American Neuro- Ophthalmology Society diatric optic nerve diseases. With her dual training in pediatric ophthalmol- Member, Walsh Committee, North American Neuro-Ophthalmology ogy and neuro-ophthalmology, she Society has a special interest in pediatric Member, Amblyopia Treatment Studies neuro-ophthalmic diseases, as well Steering Committee, Pediatric as adult patients with neurologic Eye Disease Investigator Group causes of strabismus. Reviewer for many scientific journals

Research Grants Jaeb Center for Health Research: Pediatric Eye Disease Investigator Group (PEDIG), 2/28/11–12/31/18 NIH/National Eye Institute: Binocular Summation in Strabismus, 9/1/11–8/31/16 University of California, Riverside: Integrating Perceptual Learning Approaches into Effective Therapies for Low Vision: 9/1/13–7/31/15

60 Stein Eye Institute | Faculty Public Service Natik Piri, PhD Reviewer for many scientific journals

Research Grants Associate Professor of Ophthalmology National Eye Institute: Member of the Stein Eye Institute The Neuroprotective Effect of HSP72 Induction in Experimental Glaucoma, 9/30/09–8/31/14

RESEARCH SUMMARY Retinal Ganglion Cell Degeneration in Optic Neuropathies and Neuroprotection

The main directions in Dr. Piri’s re- Another area of investigation focuses search are defining the mechanisms on understanding the degeneration of leading to retinal ganglion cell (RGC) RGCs and their axons, which is a hall- degeneration in glaucomatous neurop- mark of glaucoma. Dr. Piri’s laboratory athy; developing strategies for preserv- is analyzing retinal gene expression ing RGCs against neurodegeneration; profiles from the glaucoma model and identifying and characterizing the with the aim of identifying factors in- genes critical for RGC function and involved in the initiation and execution tegrity. Different types of RGCs have of RGC apoptosis. Study results have been identified based on their morpho- implicated several members of the logical and physiological characteristics, crystallin superfamily in this process, yet current knowledge of RGC molec- including alpha crystallins. Dr. Piri is ular biology is very limited. Dr. Piri has also studying the involvement of oxi initiated a study to identify the genes dative stress and proteins of the thio expressed in RGCs. Characterization of redoxin system, particularly in RGC RGC-expressed genes is fundamental degeneration in the glaucoma model, to a better understanding of normal and the neuroprotective effects of RGC physiology and pathophysiology. these proteins against glaucomatous RGC death.

Faculty | Stein Eye Institute 61 Public Service Pradeep S. Prasad, MD Reviewer for the scientific journal Ophthalmology

Health Sciences Assistant Clinical Professor Ophthalmology Clerkship Director at the UCLA School of Medicine Chief, Division of Ophthalmology, Harbor-UCLA Medical Center Member of the Stein Eye Institute

RESEARCH SUMMARY Vitreoretinal Surgery and Disease Management

Dr. Prasad specializes in the medical and surgical management of diseases of the retina and vitreous. His research is focused on teleretinal screening for diabetic retinopathy, applications of wide field fundus photography for retinal vascular disease, and health care delivery for low-income populations. Dr. Prasad also provides clinical supervision and instruction to resident physicians and vitreoretinal fellows as chief of the Division of Ophthalmology at Harbor-UCLA Medical Center.

62 Stein Eye Institute | Faculty Public Service Alapakkam P. Sampath, PhD Member, Association for Research in Vision and Ophthalmology Publications Committee Associate Professor of Ophthalmology Member, Neurotransmitters, Member of the Stein Eye Institute Transporters, Receptors and Calcium Study Section, NIH

Research Grants RESEARCH SUMMARY National Eye Institute: Functional Characteristics of Rod Pathways Molecular Mechanisms Underlying Early Visual Processing in the Retina, 2/1/14–7/31/16 University of Southern California: Experimental and Clinical The Sampath laboratory is interest- Investigations of Retinal Stimulation, ed in understanding the molecular 10/1/13–2/28/15 mechanisms underlying early visual processing. In particular, the focus of laboratory researchers has been on elucidating mechanisms that set the sensitivity of night vision. Night blindness, or nyctalopia, is a condition that results from abnormal signaling by the rod photoreceptors, or the retinal circuits that process rod-driven signals. Using physiological and genetic methods, the laboratory studies signal transmission in these retinal rod pathways to identify how these processes are optimized to allow our exquisite visual sensitivity.

Faculty | Stein Eye Institute 63 Public Service David Sarraf, MD Associate Editor: Retinal Cases and Brief Reports, OSLI Retina

Health Sciences Associate Clinical Professor of Ophthalmology Committee Member: BCSC Retina Committee, American Academy Member of the Stein Eye Institute of Ophthalmology Executive Committee and Chair of the Young Member’s Committe, Macula Society RESEARCH SUMMARY Member: The American Society of Retinal Specialists, Retina Society, Age-Related Macular Degeneration and Retinal Imaging Macula Society, and Gass Club Co-Director: Pacific Retina Club Dr. Sarraf has published approximate- and International Retinal Imaging ly 80 research papers, case reports, Symposium reviews, and book chapters, and he Reviewer for many scientific journals has been awarded achievement and secretariat awards by the American Research Grants Academy of Ophthalmology. Southern California Desert Retina Consultants: Intravitreal Aflibercept Dr. Sarraf’s research focus is the dry Injection for the Treatment of Submacular Vascularized Pigment and wet form of age-related macular Epithelial Detachment (EVEN Study), degeneration (ARMD), and he has 2/7/13–12/31/14 published numerous papers studying the imaging of pigment epithelial detachment and retinal pigment epi thelial tears in wet ARMD and their response to therapy. Dr. Sarraf will be principal investigator for a promising upcoming study at the Stein Eye Institute evaluating the effect of lam- palizumab to reduce the progression of geographic atrophy in dry ARMD. Dr. Sarraf has also published many papers studying novel imaging findings of various retinal diseases and was one of the first to describe ischemia of the deep retinal capillary plexus and its association with various retinal disorders, including retinal venous and artery occlusion. Dr. Sarraf will also be studying the benefits of a novel optical coherence tomography (OCT) system––OCT angiography––to continue his work on the deep retinal capillary plexus.

64 Stein Eye Institute | Faculty Honors Steven D. Schwartz, MD Featured specialist on The Charlie Rose Show series on the brain that aired April 22, 2014. In the public The Ahmanson Chair in Ophthalmology television episode devoted to blindness, Dr. Schwartz discussed Professor of Ophthalmology current investigations in the use of Chief of the Retina Division stem cells for visual restoration. Director of the UCLA Diabetic Eye Disease and Retinal Vascular Center Public Service Director of the Macula Center Board Member, American Society of Retinal Specialists Professor-in-Residence of Ophthalmology Program Committee Member, Member of the Stein Eye Institute Association for Research in Vision and Ophthalmology Diabetic Eye Disease Screening, Venice Family Clinic RESEARCH SUMMARY Research Grants Stem Cell Research Advanced Cell Technology, Inc.: A Phase I/II, Open-Label, Multicenter, Prospective Study to Determine the Dr. Schwartz is leading two new in which screening for diabetic retinop- Safety and Tolerability of Subretinal clinical trials testing the use of stem athy is conducted with a nonmydriatic Transplantation…in Patients with cell-derived retinal pigment epithelial camera (a camera that does not re- Stargardt Macular Dystrophy (SMD), cells to address vision loss in people quire dilation of the eyes) as part of 3/23/11–3/11/15 suffering from Stargardt macular dys- each patient’s regular diabetes treat- Advanced Cell Technology, Inc.: trophy and dry age-related macular ment. Results are telecommunicated A Phase I/II, Open-Label, Multicenter, Prospective Study to Determine the degeneration. to specialists at the Stein Eye Institute Safety and Tolerability of Subretinal for interpretation and further action. Transplantation…in Patients with Retinal Diseases Advanced Dry (AMD) 4/5/11–3/11/15 Dr. Schwartz’s primary areas of re- Advanced Cell Technology, Inc.: search include early diagnosis and Research with Retinal Cells Derived from Stem Cells for Geographic treatment of diseases such as reti- Atrophy Secondary to Myopic Macular nopathy of prematurity (ROP), diabet- Degeneration, 4/10/14–9/1/16 ic eye disease, and macular degener- Allergan Sales, LLC: DEX PS DDS ation. Additionally, his focus includes Applicator System in the Treatment of development and evaluation of novel Patients with Diabetic Macular Edema, medical device technologies, imag- 8/25/05–12/31/13 ing technologies, surgical equipment Gen Vec, Inc.: Long Term Follow-Up (including surgical robots), and drug- Protocol for Genvec Inc. Gene Transfer Product Candidates in Clinical delivery systems, with particular em- Development…, 2/27/09–2/26/24 phasis on diagnostic and treatment Neurotech Pharmaceuticals, Inc.: applications. Dr. Schwartz’s clinical Phase I Multicenter Open Label research focuses on trials of novel Safety and Tolerability Clinical Trial of pharmacotherapeutic agents to dis- Ciliary Neurotrophic Factor (CNTF) in Patients with Macular Telangiectasis cover treatments for both wet and Type 2, 7/19/11–7/18/15 dry age-related macular degeneration, Lowy Medical Research Institute: ROP, and diabetic retinopathy. A Natural History of Macular (Parafoveal) Telangiectasia, Through innovative teleophthalmolog- 9/1/05–12/31/15 ical approaches to screen for eye dis- Pfizer, Inc.: A Phase I/II, Open-Label, eases, such as diabetic retinopathy Prospective Study to Determine the and ROP, Dr. Schwartz is dedicated Safety and Tolerability of Subretinal to improving both the quality of and Transplantation…in Patients with access to specialized ophthalmology Geographic Atrophy Secondary to Myopic Macular Degeneration, care. Currently, a collaborative program 4/10/14–9/1/16 with UCLA’s Gonda Diabetes Center and Venice Family Clinic is underway,

Faculty | Stein Eye Institute 65 Public Service Hui Sun, PhD Ad hoc Reviewer, National Science Foundation, National Eye Institute (United States), Health Research Board Associate Professor of Physiology and Ophthalmology (Ireland), and Medical Research Council (United Kingdom) Howard Hughes Medical Institute Reviewer for many scientific journals Member of the Stein Eye Institute Research Grants National Eye Institute: Molecular Mechanism of Vitamin A Uptake for RESEARCH SUMMARY Vision, 12/1/13–11/30/17 Howard Hughes Medical Institute: Molecular Mechanism of Vitamin A Transport for Vision; Early Career Scientist Award, Identification of New Therapeutic Targets 9/1/09–8/31/15 for Blinding Diseases Research to Prevent Blindness: Ophthalmic Research Award, 1/1/12–12/31/14 Dr. Sun’s laboratory studies the molecular mechanism of vitamin A transport for vision and new therapeutic targets for blinding diseases such as age-related macular degeneration. Vitamin A is essential for vision because it is the precursor for the chro- mophore of photoreceptor proteins and also plays critical roles in eye development. Plasma retinol binding protein (RBP) is the principal carrier of vitamin A in the blood and is essential for mobilizing the hepatic vitamin A store. Dr. Sun’s laboratory identified the long-sought RBP receptor as a multitransmembrane protein of previously unknown function. It functions simultaneously as a membrane receptor and a membrane transporter that mediates cellular uptake of vitamin A. His laboratory is using a variety of techniques to study this membrane transport system. Dr. Sun is also identifying new therapeutic targets. Specifically, his laboratory recently identified new factors that protect cone photoreceptor cells and membrane receptors for a factor that has broad therapeutic value. The overall goal is to uncover novel mechanisms that protect retina and photoreceptor cells as strategies in treating blinding diseases.

66 Stein Eye Institute | Faculty Public Service Gabriel H. Travis, MD Scientific Advisory Panel Member, the Karl Kirchgessner Foundation Vision Science Program Charles Kenneth Feldman Chair in Ophthalmology Grant Reviewer, National Institutes of Professor of Ophthalmology Health: The Biology and Diseases of the Posterior Eye Study Section Co-Chief of the Vision Science Division Reviewer, Howard Hughes Medical Associate Director of the Stein Eye Institute Institute Investigators Reviewer for many scientific journals

Research Grants RESEARCH SUMMARY Bruce Ford and Anne Smith Bundy Biochemistry of Vertebrate Photoreceptors and Foundation: 8/16/11–8/15/14 National Eye Institute: The Role of Mechanisms of Retinal Degeneration Müller Cells in Visual Pigment Regeneration, 7/1/13–6/30/18 Dr. Travis’ laboratory uses biochemi- Still another project in Dr. Travis’ lab- National Eye Institute: Vision Science cal and genetic approaches to study oratory concerns the mechanism of Training Grant for the Stein Eye the visual cycle and its role in retinal visual-pigment regeneration in cone Institute (Principal Investigator), 9/30/11–9/29/16 and macular degenerations. Vision in photoreceptors. Despite the impor- vertebrates is mediated by two types tance of cones, little is known about of light-sensitive cells: rods and cones. how visual pigments are replenished These cells contain light-detecting mol- to permit sustained vision under day- ecules called opsin pigments. Detec- light conditions. Recent results from tion of a single light particle bleaches Dr. Travis’ group point to the exis- the opsin pigment. Restoring light sen- tence of a new enzymatic pathway sitivity to a bleached opsin involves an for regenerating visual pigments in enzymatic pathway called the visual cones. His group is currently working cycle. Mutations in the genes for many to purify and clone the enzymes that proteins of the visual cycle cause in- define this new biochemical pathway. herited blinding diseases. One project in Dr. Travis’ laboratory studies the function of a transporter protein in rods and cones called ABCA4. Mutations in the human ABCA4 gene cause recessive Star- gardt macular degeneration and cone- rod dystrophy. Dr. Travis’ group generated mice with a null mutation in this gene. Biochemical analysis of the phenotype in these ABCA4 “knock- out” mice led them to the function of ABCA4 in photoreceptors, and the biochemical etiology of Stargardt disease. This understanding suggested a pharmacological strategy to reverse the biochemical defect in patients with Stargardt disease and age-related macular degeneration. A phase II clinical trial is currently underway to test a drug based on this strategy as a treatment for age-related macular degeneration. Another ongoing project in Dr. Travis’ laboratory characterizes Rpe65, which catalyzes the critical isomerization step in the visual cycle. Previously, Dr. Travis and co-workers identified Rpe65 as the retinoid isomerase.

Faculty | Stein Eye Institute 67 Public Service Irena Tsui, MD Committee Member, UCLA Women in Medicine and Science

Assistant Professor of Ophthalmology Care Harbor LA Free Clinic Reviewer for many scientific journals Member of the Stein Eye Institute

RESEARCH SUMMARY Clinical Vitreoretinal Research

Dr. Tsui’s research focuses on improving clinical outcomes in patients with retinal diseases. Her areas of interest include retinopathy of prematurity, diabetic retinopathy, ultra-wide field imaging, surgical techniques, and studying patient-centered outcomes in veterans. In addition to providing patient care at the Stein Eye Institute in West- wood, Dr. Tsai also sees patients at the Doheny Eye Center UCLA–Arcadia.

68 Stein Eye Institute | Faculty Public Service Federico G. Velez, MD Editorial Board Advisory Panel Member, Treatment Strategies—Pediatrics, The Cambridge Research Centre Health Sciences Assistant Clinical Professor of Ophthalmology Editorial Board Member, Journal of Member of the Stein Eye Institute the American Association of Pediatric Ophthalmology and Strabismus, Journal of the Colombian Society of Ophthalmology, and Video Journal of Ophthalmology RESEARCH SUMMARY Member, American Academy of Strabismus and Childhood Eye Disorders Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, Latin American Council of Dr. Velez’s primary research interest Strabismus, Latin American Pediatric Ophthalmology Society, Colombian is studying the mechanisms of con- Society of Ophthalmology, and genital and acquired forms of stra- Colombian Society of Pediatric bismus. He has participated in the Ophthalmology and Strabismus development of guidelines for preop- Reviewer for many scientific journals erative assessment and surgical approaches to patients with convergent (esotropia), divergent (exotropia), and vertical forms of strabismus, and has developed new techniques to treat pediatric patients with eyelid abnormalities and cataracts. Dr. Velez has recently completed studies that apply bioengineering technol ogy to the correction of ocular motil ity disorders. He has also identified a new ocular motility disorder in patients with the human immunodeficiency virus. He provides patient care at the Stein Eye Institute in West- wood and the Doheny Eye Center UCLA–Orange County.

Faculty | Stein Eye Institute 69 Public Service David S. Williams, PhD Scientific Advisory Board Member, Foundation Fighting Blindness

Jules and Doris Stein Research to Prevent Blindness Professor of Ophthalmology Executive Board Member, Sustainability Council of New Zealand Professor of Neurobiology Committee Member, ARVO/ Member of the Stein Eye Institute International Society for Ocular Cell Biology Associate Editor, Visual Neuroscience

RESEARCH SUMMARY Research Grants National Eye Institute: RPE Cell Cell Biology of the Retina and Inherited Retinal Disease Biology of Myosin VIIa, 7/1/09–6/30/15 National Eye Institute: Dr. Williams’ laboratory focuses on the The Photoreceptor Cilium, cell biology of photoreceptor and reti- 5/1/13–4/30/18 nal pigment epithelium cells. His group National Neurovision Research is especially interested in proteins Institute, Foundation Fighting Blindness: Wynn-Gund Translational that function in transport and com- Research Acceleration Program Award: partmentalization within these cells. MY07A Gene Therapy for Usher 1B, These proteins include those that un- 7/1/08–4/20/14 derlie Usher syndrome. A translational Research to Prevent Blindness: area of his research involves gene ther- Doris and Jules Stein Research to Prevent Blindness Professorship, apy experiments aimed at preventing 1/1/08–12/31/14 the blindness that ensues from Usher University of Pennsylvania: syndrome type 1B. Degradative Processes in RPE-Photoreceptor Renewal, 2/1/14–1/31/15 UCLA Broad Stem Cell Research Center: IPSC-JSEI Collaboration Project, 4/1/14–4/31/15

70 Stein Eye Institute | Faculty Public Service Xian-Jie Yang, PhD Ad Hoc Grant Reviewer, Foundation Fighting Blindness, National Science Foundation, Medical Research Council Ernest G. Herman Chair in Ophthalmology and Wellcome Trust in the United Kingdom, the Research Grant Council Professor of Ophthalmology of Hong Kong, Biomedical Research Member of the Stein Eye Institute Council and National Medical Research Council of Singapore, Israel Science Foundation, and the Nation Science Foundation of China Standing Member, National Institutes RESEARCH SUMMARY of Health, Biology of the Visual System Development and Disease Therapy of the Retina study section Editorial Board Member, Visual Neuroscience, Translational Vision Dr. Yang is interested in the molecular and cellular mechanisms underlying retinal Science & Technology development and disease. Her research efforts are directed toward understanding Reviewer for many scientific journals how retinal progenitor (precursor) cells become different types of mature retinal neurons during formation of the retina. To achieve these goals, her laboratory uses Research Grants a variety of molecular and cellular approaches to study genes involved in cell-to-cell National Eye Institute: Hedgehog communication and neuronal differentiation. As important research tools Dr. Yang Signaling in Photoreceptor utilizes special laboratory-based viruses to mediate gene transfer and advanced Differentiation and Maintenance, 12/1/09–11/30/14 transgenic technologies. In addition, Dr. Yang’s laboratory is developing stem cell- based cell therapy for retinal degenerative diseases. Her research will enhance researchers’ capabilities to manipulate retinal progenitor and stem cells, thereby contributing to the effort to combat retinal degenerative diseases.

Faculty | Stein Eye Institute 71 FACULTY Brian A. Francis, MD, MS Hugo Y. Hsu, MD DOHENY EYE CENTERS UCLA Health Sciences Clinical Professor Health Sciences Associate Clinical Professor This year, we welcomed our newest Medical Director, Doheny Eye Center UCLA Department of Ophthalmology UCLA–Orange County RESEARCH SUMMARY faculty members: Doheny Eye Insti- Cornea and tute researchers and clinicians who RESEARCH SUMMARY are now also Doheny Eye Centers Glaucoma External Diseases UCLA faculty. The listed UCLA ap- Dr. Francis’ clinical specialties are glau- Dr. Hsu specializes in corneal infec- pointments were pending at the close coma and cataract. His research activ- tion and inflammation, corneal trans- of the 2013–2014 academic year. ities include: innovative glaucoma sur- plantation, anterior segment recon- geries, minimally invasive glaucoma struction, and cataract surgery. His Vikas Chopra, MD surgery, novel visual field techniques, research interests include corneal glaucoma diagnostic and functional infection, ophthalmic antibiotics, and Health Sciences Associate Clinical Professor imaging, anterior segment imaging cataract extraction. (ultrasound biomicroscopy and Fouri- Medical Director, er domain optical coherence tomogra- PRACTICE LOCATIONS Doheny Eye Center UCLA–Pasadena phy), and glaucoma laser surgery. Doheny Eye Center UCLA–Arcadia RESEARCH SUMMARY Doheny Eye Center UCLA– PRACTICE LOCATIONS Orange County Glaucoma Doheny Eye Center UCLA–Arcadia Dr. Chopra specializes in glaucoma, Doheny Eye Center UCLA–Pasadena Doheny Eye Center UCLA– and his research activities include ad- Orange County vanced optic nerve and retinal nerve Alex A. Huang, MD, PhD fiber layer imaging for early glaucoma Doheny Eye Center UCLA–Pasadena detection, as well as development Assistant Professor and validation of novel parameters for Gad Heilweil, MD use in anterior segment optical coher- RESEARCH SUMMARY ence tomography devices as principal Clinical Instructor of Ophthalmology Glaucoma investigator at the Doheny Image RESEARCH SUMMARY Dr. Huang’s clinical specialties in- Reading Center. Dr. Chopra also eval- clude glaucoma, minimally invasive uates laser and surgical techniques Degenerative Retinal Disease glaucoma surgery, trabeculectomy, for the management of glaucoma. Dr. Heilweil’s research activities in- glaucoma drainage devices, cyclode- clude stem-cell therapy for degenera- struction, and complex cataracts. His PRACTICE LOCATIONS tive retinal disease; retinal and uveal research activities involve character- Doheny Eye Center UCLA–Arcadia drug toxicity; and pharmacokinetics izing post-trabecular meshwork and Doheny Eye Center UCLA–Pasadena of intravitreal drugs. In addition to scleral changes in glaucoma, optical providing patient care at the Doheny coherence tomography visualization Eye Centers UCLA, Dr. Heilweil sees of aqueous humor outflow pathways patients at the Stein Eye Institute in the eye, and angiographic visual- in Westwood. ization of aqueous humor outflow in the eye. PRACTICE LOCATIONS Doheny Eye Center UCLA–Arcadia PRACTICE LOCATION Doheny Eye Center UCLA– Doheny Eye Center UCLA–Pasadena Orange County Doheny Eye Center UCLA–Pasadena

72 Stein Eye Institute | Faculty John A. Irvine, MD Olivia L. Lee, MD Peter A. Quiros, MD Health Sciences Clinical Professor Health Sciences Health Sciences Assistant Clinical Professor Associate Clinical Professor Medical Director, Doheny Eye Centers UCLA RESEARCH SUMMARY RESEARCH SUMMARY RESEARCH SUMMARY Cornea/External Diseases and Neuro-Ophthalmology Cornea and External Diseases Uveitis; Corneal Imaging Specializing in neuro-ophthalmology, Dr. Irvine’s clinical specialties are cor- Dr. Lee practices two subspecialties the clinical specialties of Dr. Quiros nea and external diseases (eg, tumors, of ophthalmology: cornea/external dis- are: optic nerve disease, including op- infections), anterior segment surgical eases and uveitis. She has particular tic neuritis and multiple sclerosis; dou- consultation, and prosthetic replace- interest in inflammatory ocular sur- ble vision and adult strabismus; eye ment of the ocular surface ecosystem face disease, corneal melts, pterygia, pain, headache, and idiopathic intra- (PROSE). His research activities focus and anterior segment complications cranial hypertension; Graves disease; on ocular infections. of uveitis. Dr. Lee performs all types orbital inflammatory syndromes; and of corneal transplants (eg, penetrat- stroke. Dr. Quiros’ research activities PRACTICE LOCATIONS ing, lamellar, endothelial and femto- include idiopathic intracranial hyperten- second laser-assisted keratoplasty), sion, headache, ocular myasthenia gra- Doheny Eye Center UCLA–Arcadia as well as complex cataract surgery vis, Graves disease, optic neuritis and Doheny Eye Center UCLA– in uveitic eyes. multiple sclerosis, and visual rehabili- Orange County tation after stroke. Dr. Quiros was the Doheny Eye Center UCLA–Pasadena Dr. Lee’s research interests focus on principal investigator for the recently anterior segment imaging applied to completed idiopathic intracranial hyper- the tear film, cornea, and conjunctiva. tension treatment trial and is currently Anne R. Kao, MD With her expertise in corneal imaging, the principal investigator for the longi- a specular microscopy reading center Health Sciences tudinal idiopathic intracranial hyperten- Assistant Clinical Professor was developed at the Doheny Image sion treatment trial. Dr. Quiros is also a Reading Center, where she serves as member of the Neuro-Ophthalmology RESEARCH SUMMARY an investigator. Researcher and Disease Investigators Orbit and Ophthalmic Consortium (NORDIC) and is the local PRACTICE LOCATIONS Plastic Surgery; NORDIC director. Neuro-Ophthalmology Doheny Eye Center UCLA–Arcadia Doheny Eye Center UCLA– PRACTICE LOCATIONS Dr. Kao specializes in orbit and oph- Orange County Doheny Eye Center UCLA– thalmic plastic surgery, and neuro- Orange County ophthalmology. Her clinical specialties Doheny Eye Center UCLA–Pasadena include ptosis (drooping eyelids), eye- Doheny Eye Center UCLA–Pasadena lid tumors, orbital tumors, thyroid eye disease, blepharospasm, optic nerve Kenneth L. Lu, MD disorders, optic nerve sheath fenes- Health Sciences tration, strabismus (ie, eye muscle Associate Clinical Professor disorders), and strabismus surgery. Medical Director, Doheny Eye Center UCLA–Arcadia PRACTICE LOCATIONS RESEARCH SUMMARY Doheny Eye Center UCLA– Orange County Cataract and Doheny Eye Center UCLA–Pasadena Refractive Surgery Dr. Lu specializes in cataract and refractive surgery, and his research activities are focused in the same areas.

PRACTICE LOCATION Doheny Eye Center UCLA–Arcadia

Faculty | Stein Eye Institute 73 Daniel B. Rootman, MD, MS Alfredo A. Sadun, MD, PhD STEIN EYE INSTITUTE MEMBERS BASED AT OTHER SITES Assistant Professor Professor Vice Chairman, Doheny Eye Centers James W. Bisley, PhD RESEARCH SUMMARY UCLA Orbit and Ophthalmic Assistant Professor of Neurobiology Plastic Surgery RESEARCH SUMMARY and Psychology Dr. Rootman is an orbit and oph Neuro-Ophthalmology Member of the Stein Eye Institute thalmic plastic surgery specialist. His Clinical specialties of Dr. Sadun in- Member of the clinical expertise includes Graves dis- clude neuro-ophthalmology, optic Brain Research Institute ease, orbital surgery, orbital tumors, nerve, optic neuropathies (eg, pos- RESEARCH SUMMARY ptosis, lacrimal disorders, blepharo terior ischemic optic neuropathy, an- plasty, blepharospasm, Botox®, cos- terior ischemic optic neuropathy, and Cognitive Processing of metic dermal fillers, endoscopic eye- traumatic optic neuropathy), Leber Visual Information row lift, eyelid surgery, eyelid tumors, hereditary optic neuropathy, toxic and Dr. Bisley’s research revolves around and trauma. Research activities are nutritional optic neuropathies, vision in understanding the neural mechanisms on developing and refining patient- AIDS, and other central nervous sys- underlying the cognitive processing centered outcome measures for sur- tem disorders. Dr. Sadun’s research of visual information. These cognitive gical care; randomized clinical trials in activities focus on human visual neuro processes include visual perception, surgery, including ptosis, Graves orbi- anatomy; retinal ganglion cell degen- visual memory, and visual attention. topathy and lacrimal disease; health eration and regeneration; axon pop- His recent work has focused on how economics of eyelid and facial sur- ulations in the human optic nerve in the responses of neurons in the pos- gery; sociodemographics of facial development, aging, and disease; and terior parietal cortex are involved in trauma; physiology and pathobiology mitochondrial impairments as a cause the allocation of visual attention to of ptosis; new approaches to surgery; of optic neuropathy. neurons in visual cortices and how and measurement and assessment in they guide eye movements in goal- medical education. In addition to pro- PRACTICE LOCATION directed visual search. viding patient care at the Doheny Eye Doheny Eye Center UCLA–Pasadena Centers UCLA, Dr. Rootman sees patients at the Stein Eye Institute in Nicholas C. Brecha, PhD Westwood. Deming Sun, MD Professor of Neurobiology Professor and Medicine PRACTICE LOCATION Doheny Eye Center UCLA–Pasadena RESEARCH SUMMARY Vice Chair of the Department Research Scientist of Neurobiology Member of the Stein Eye Institute SriniVas R. Sadda, MD Dr. Sun is a researcher whose primary areas of investigation include Member of the Professor uveitis, autoimmune diseases, optic Brain Research Institute neuritis, animal disease models, and Member of CURE: Center for RESEARCH SUMMARY T-cell biology. Digestive Diseases Retinal and Macular Diseases RESEARCH SUMMARY Dr. Sadda specializes in age-related macular degeneration, hereditary ret- James C. H. Tan, MD, PhD Functional and Structural inal degenerations, diabetic retinopa- Associate Professor Organization of the thy, venous occlusive disease, tele- Mammalian Retina medicine screening and consultation RESEARCH SUMMARY Dr. Brecha’s research focuses on the programs, as well as retinal disease Glaucoma elucidation of the structural organiza- diagnosis and classification. His re- Dr. Tan specializes in the medical and tion of the outer and inner retina for search activities include: quantitative, surgical treatment of glaucoma, as understanding visual information pro- automated retinal image analysis; well as cataract surgery. His glauco- cessing by the retina. Morphological retinal substructure assessments; ad- ma research includes investigations studies have defined cell types and vanced retinal imaging technologies; into aqueous physiology and biology, classes, and microcircuitry organiza- genotype-phenotype correlative stud- pharmacology, and ocular imaging. tion in the retina, and neurochemical ies; and vision restoration technol- studies have investigated the action ogies, such as stem cells and pros- PRACTICE LOCATIONS of neurotransmitters and neuroac- thetic vision. tive peptides in retinal microcircuits. Doheny Eye Center UCLA–Arcadia Experimental work has clarified the PRACTICE LOCATIONS Doheny Eye Center UCLA–Pasadena functional role of neuropeptides in the Doheny Eye Center UCLA–Arcadia inner retina and supports the current Doheny Eye Center UCLA–Pasadena

74 Stein Eye Institute | Faculty hypothesis that certain neuropeptides is being developed and pioneered by Dario L. Ringach, PhD are modulators of retinal neurons and Dr. Coleman at the Institute’s Center Professor of Neurobiology circuitry that influence light and dark for Eye Epidemiology. and Psychology, adaptation; they also influence retinal Biomedical Engineering Program circuitry that mediates form vision. Member of the Stein Eye Institute Other experimental work has investi- Antoni Ribas, MD gated the photoreceptor synaptic triad, Professor of Medicine, Surgery, and RESEARCH SUMMARY a specialized synaptic complex that is Molecular and Medical Pharmacology the site of initial transfer of visual in- Visual Perception Member of the Stein Eye Institute formation from photoreceptors and is and Neurophysiology critically important for visual process- RESEARCH SUMMARY Dr. Ringach’s research focuses on ing. Experimental studies are testing the relationship between eye move- the idea that a vesicular mechanism The Immune System and ments and visual perception, as well underlies transmitter release from hor- Oncogene-Targeted Therapies as how motor planning and execution, izontal cells in this triad to mediate in the Treatment of Cancer such as reaching, grasping, navigat- feedback and feed forward signaling, Dr. Antoni Ribas conducts research ing, and adjusting body posture, is which is critically important for the for- focused on melanoma, an aggres- influenced by visual information and mation of visual receptive fields. These sive form of skin and eye cancer. His impaired vision. In collaboration with investigations are fundamental steps research aims at developing more a team of neurosurgeons at UCLA, in establishing the retina’s functional effective and less toxic therapies for Dr. Ringach’s laboratory is also record- organization and provide the basis for patients with advanced melanoma by ing the brain activity of patients with understanding the pathophysiology of studying how the immune system epilepsy who are undergoing clinical retinal dysfunction. can be effectively used to fight cancer evaluation for surgical treatment. This and also how targeted therapies can unique opportunity is shedding new specifically block cancer genes. His light into the processes involved in Patrick T. Dowling, MD, MPH projects include laboratory and clinical object recognition and perception. Chairman of the UCLA Department of translational research in adoptive cell Family Medicine transfer therapy using T-cell receptor Kaiser Permanente Endowed engineered lymphocytes designed to Guido A. Zampighi, PhD Professor of Community Medicine seek out melanoma cells, with the Professor of Neurobiology application of molecular imaging and Member of the Stein Eye Institute advanced monitoring of the immune Member of the Stein Eye Institute system to better study how it can Health Care Policy and Access RESEARCH SUMMARY for Underserved Populations fight cancer. Another way to engage an anti-cancer immune response is Intercellular Junctions Dr. Dowling is a member of the through the use of immune modulat- and Communication California Community Foundation’s ing antibodies, in particular by releas- Board of Directors and the Board of A fundamental property of cells or- ing the immune breaks CTLA4 and Trustees at the Charles Drew Univer- ganized in tissues is their ability to PD-1. He is also testing, both in the sity of Medicine and Science. He has communicate with each other via laboratory and the clinic, novel target- received numerous grants for interna- highly specialized areas of plasma ed therapies blocking cancer-causing tional medical graduate training, res- membrane contact, called junctions. events that result in melanoma, as idency training, and family medicine Dr. Zampighi is studying the gap junc- well as the potential clinical applica- training. He has made unparalleled tion and the chemical synapse, two tions of nanoparticle delivery of siR NA, contributions to the community and specialized junctions that mediate which interferes with gene expres- to the training of physicians to sup- electrical and chemical transmission, sion related to cancer. Dr. Ribas’ goal port the community at a primary level. respectively. The gap junction is com- is to bring new concepts from the lab- He is a prior Commissioner of Public posed of specialized channels con- oratory to the clinic to help patients Health for the Los Angeles County taining small hydrophilic pores that with advanced melanoma. Department of Health and currently span the two plasma membranes and has funding for an innovative program the intervening extracellular space to increase the number of Hispanic (the cell-to-cell channel). He is inves- physicians in California. Dr. Dowling tigating the high-resolution structure worked closely with Dr. Anne Cole- of the channels as well as the mech- man on the Remote Area Medical anisms of assembly, insertion, and re- Program, which provided care to the trieval of the connexin proteins that homeless and indigent in the Los An- form them. The chemical synapse is geles community. Dr. Dowling’s pres- composed of a presynaptic neuron ence as a member of the Stein Eye filled with small diameter vesicles Institute adds a new dimension that that contain a high concentration of neurotransmitters and a postsynaptic

Faculty | Stein Eye Institute 75 neuron with receptors. He is studying Barry L. Burgess, BS brain. This model system is the only the mechanisms by which the synap- paradigm available for future investiga- Research Specialist IV tic vesicles attach (“dock”) to the pre- tions on early childhood cataracts. synaptic membrane. He uses structur- RESEARCH SUMMARY al (electron microscopy), biochemical, and electrophysiological techniques Ocular Melanoma Yekaterina Gribanova, MD Molecular Genetics in an attempt to identify, purify, and Associate Research Specialist I characterize the channels and trans- Mr. Burgess provides research sup- porters of both junctions in an effort to port for the Ophthalmic Oncology RESEARCH SUMMARY increase understanding of the mecha- Center under the direction of Tara A. Characterization of Novel nisms mediating cell communication. McCannel, MD, PhD. His research in- Retinal Protein 7R terests include investigation of cyto genetic abnormalities of ocular mela A novel retinal protein, 7R, has been noma and gene discovery for the linked to auto-somal recessive reti PROFESSIONAL RESEARCH metastatic form of this cancer. He nitis pigmentosa, a disease leading SERIES has developed highly characterized to incurable blindness. Dr. Gribanova cell lines from both primary ocular is using immunohistochemical anal- Novruz Ahmedli, PhD melanomas and metastatic lesions to ysis, in situ proximity ligation assay, Associate Research Ophthalmologist complement the Center’s study of bi- co-immunoprecipitation, immunoelec- opsy material. His research goals are tron cryomicroscopy, and gradient RESEARCH SUMMARY to identify biochemical pathways that flotation fractionation combined with Studies on Müller Cells lead to a metastatic outcome and to solid-phase immunoadsorption to de- find targets for therapeutic interven- termine and characterize 7R function Zbed4 is a multifunctional protein that tion that may preempt the progres- in photoreceptor cells. These methods plays a key role in the cells where it sion of metastatic disease. will identify 7R’s interacting partners is expressed. Dr. Ahmedli’s results and indicate whether 7R is contri indicate that this important protein buting to the sorting and transport of appears early in embryonic life and Rajendra Gangalum, PhD phototransduction proteins to the out- while in mouse retina it is detected er segment of photoreceptor cells. only in Müller cells, in humans it is ex- Assistant Research Specialist II pressed in cones and Müller cells. In RESEARCH SUMMARY addition, he has found that the length Joanna J. Kaylor, PhD and shape of Müller cell processes Function and Regulation Assistant Research Ophthalmologist depend on the levels of Zbed4. Dr. of Small Heat Shock Ahmedli’s work aims to identify the Protein αB-crystallin RESEARCH SUMMARY pathway, which is essential for proper in Health and Disease functioning of Zbed4 in Müller cells. Characterization and Dr. Gangalum’s research seeks to Identification of the Enzymes gain understanding of the physiolog- of the Cone Visual Cycle ical function of αB-crystallin in the Christian Altenbach, PhD developing ocular lens and nonocular Bright light vision is solely mediated Research Ophthalmologist tissues. αB-crystallin has been shown by the cone photoreceptor cells of to associate with pathologies such as the retina. Recent biochemical evi- RESEARCH SUMMARY cataracts, cancer, age-related macular dence supports the existence of a Structure and Function degeneration (AMD), and other neuro- new metabolic pathway in the retina of Rhodopsin degenerative diseases. Dr. Gangalum for the regeneration of cone opsin has discovered that B-crystallin is a visual pigment. Dr. Kaylor is using The membrane protein rhodopsin is a α Golgi-associated membrane protein, biochemistry and molecular biology critical first step in visual transduction, secreted into extracellular medium techniques to characterize and identi- converting light energy into a chem- via exosomes from retinal pigment fy the enzymes responsible. Her work ical form in the photoreceptor cell of epithelial cells. These findings explain has led to the identification of the first the eye. To understand this process how B-crystallin is detected in the vitamin A retinol isomerase, dihydro on a detailed molecular level, Dr. α protein-lipid deposits know as drusen ceramide desaturase-1 (DES1). Un- Altenbach is using site-directed spin in AMD. Dr. Gangalum has generated derstanding the role of DES1 in vision labeling and electron paramagnetic the transgenic mice model of child- is the current focus of her research. resonance spectroscopy to study the hood cataract to study the molecular structure of rhodopsin in the absence basis of its pathology. Cataracts in in- of light, as well as the changes in fants are debilitating, because opaci- structure caused by light. ties in the lens hinder the transmission of light to the retina, which impairs the development of visual cortex in the

76 Stein Eye Institute | Faculty Jacky M. K. Kwong, PhD Maria Carolina Ortube, MD regulatory genes) causes AMD is not known. To investigate the relation- Associate Research Ophthalmologist Assistant Research Ophthalmologist ship between abnormal build-up of Clinical Director of Research Studies, RESEARCH SUMMARY vitamin A-based toxic compounds Retinal Disorders and Ophthalmic such as A2E and the complement sys- Genetics Division Degeneration of tem, Dr. Radu will generate a mouse Retinal Ganglion Cells RESEARCH SUMMARY lacking both genes ABCA4 and CFH. and Neuroprotection This complex mouse genetic model Dr. Kwong’s research goal is to iden- Ocular Genetics will advance understanding of the tify novel neuro-protective therapies Dr. Ortube is a fellowship-trained relationship between lipofuscin accu- for glaucoma. To understand the loss specialist in pediatric ophthalmology, mulation, complement activation, and of retinal ganglion cells in glaucoma, strabismus, and pediatric genetic con- photoreceptor degeneration in AMD, his research focuses on the response ditions. She is an investigator in four and it will be a valuable tool for devel- and the cell death pathway of retinal clinical and translational research proj- oping new treatments for this disease. ganglion cells in animal models related ects related to ocular genetics. The ge- to optic nerve injury and glaucoma. netics of inherited eye disorders and Dr. Kwong and his colleagues recent- Stargardt protocols provide clinical Charles “Dutch” Ratliff, PhD ly found retinal ganglion cell-specific characterization of affected individu- Assistant Project Scientist proteins. He is utilizing these proteins als and at-risk family members. The to visualize retinal ganglion cells and Genetics of Age-Related Maculopathy Information Processing and to investigate their function in retinal study focuses on the genetic and en- Metabolism in the Retina ganglion cells during degeneration. vironmental risk factors that contribute Dr. Ratliff investigates the mecha- He is also applying pharmacologic to age-related maculopathy. The proto- nisms by which the retina creates a techniques to evaluate therapies that cols use state-of-the-art imaging and metabolically efficient representation enhance endogenous neuroprotective functional technologies in conjunction of visual information. This work com- responses against glaucomatous, ex- with molecular genetic testing to iden- bines techniques from patch-clamp citotoxic, and axonal damage to nerve tify causative genes and mutations. electrophysiology, mathematical mod- cells, and is utilizing multidisciplinary Dr. Ortube has a special interest in eling, and molecular simulations. methods to understand the protec- children born with craniofacial ocular tive mechanisms. disorders. She is also investigating a simple, noninvasive, rapid method Alberto C. Ruiz-Morales for widespread screening of diabetics Research Specialist IV Anna Matynia, PhD using the pupillary light reflex. This Assistant Research Ophthalmologist study aims to identify those who may RESEARCH SUMMARY require medical attention and/or thera- Visual Cycle RESEARCH SUMMARY py for diabetic retinopathy. Dr. Ortube is a co-investigator in collaborative re- Mr. Ruiz is a molecular biologist who Neural and Molecular Basis search efforts with the University of has been directly involved in the clon- of Photoallodynia Pittsburgh and Neurokinetics, Inc. ing and characterization of important Dr. Matynia is investigating the mech- enzymes critical for the proper func- anisms of photoallodynia, a condition tioning of the visual cycle, such as the in which normal levels of light pro- Roxana A. Radu, MD lecithin retinol acyltransferase (LRAT) duce or enhance ocular or headache Associate Research Ophthalmologist enzyme. Another area of investiga- pain. Using a combination of behav- tion is the generation and evaluation ioral, molecular, and cellular approach- RESEARCH SUMMARY of knock-out mouse models for LRAT es in genetic mouse models, the goal Retinoids Metabolism and a second visual cycle enzyme, is to identify mechanisms of light- the retinol binding protein receptor in the Eye and pain association for different causes STRA6. Currently, Mr. Ruiz is analyzing of photoallodynia, including corneal, Underlying Mechanisms of genes, such as ARMS2 and HTRA1, retinal, and central causes such as Macular Degeneration which are thought to be involved in dry eye injury, achromatopsia, and Dr. Radu’s research focuses on the vi- age-related macular degeneration. migraine respectively. The research sual cycle and underlying biochemical findings will form the basis of treat- and molecular mechanisms of macu- ment strategies for this condition. lar degeneration. She studies the in vivo association of the complement negative regulator genes and age- related macular degeneration (AMD) development. The mechanism by which dysfunction of complement factor H (CFH, one of the complement

Faculty | Stein Eye Institute 77 Kiyo Sakagami, PhD microvesicles enriched in OA1 Gavin G. Bahadur, MD mRNA/protein for the treatment of Assistant Research Ophthalmologist Associate Physician Diplomate ocular albinism. Clinical Instructor of Ophthalmology RESEARCH SUMMARY Hedgehog Signaling and Quan Yuan, PhD RESEARCH SUMMARY PTEN/PI3K Signaling on Assistant Research Ophthalmologist Comprehensive Retinal Development Ophthalmology, including Dr. Sakagami’s research aims to un- RESEARCH SUMMARY Cataract, Pterygium, and derstand how extracellular signals co- Biochemistry of Visual Cycle Glaucoma Surgery ordinate retinal cell fate and behavior and Retinal Degeneration Dr. Bahadur teaches medical students during development, using genetic during their ophthalmology surgical strategies for conditional mutagenesis Dr. Yuan’s research focuses on the biochemical mechanism of key pro- subspecialties clinical rotation. He is in the mouse. The more specific goals a full-time comprehensive ophthal- of her research are to understand how teins involved in the retinoid visual cycle. Retinal Pigment Epithelium Specif- mologist at the Stein Eye Center in hedgehog signaling regulates bHLH Santa Monica. genes to determine cell cycle and cell ic Protein 65kD (Rpe65) is one of the fate decisions and to investigate the most important enzymes in the visual cycle that converts all-trans-retinyl es- potential role of PTEN/PI3K signaling Laura Bonelli, MD on retinal formation. ter to 11-cis-retinol and regenerates the visual pigment. He has investigat- Associate Physician Diplomate ed the biochemistry behind the inter- Ned Van Eps, PhD action of Rpe65 with ER membrane RESEARCH SUMMARY and resolved the puzzle of Rpe65 Assistant Research Ophthalmologist Neuro-Ophthalmology membrane association. He is also in- and Comprehensive RESEARCH SUMMARY vestigating the chemical mechanism Ophthalmology that regulates Rpe65 enzymatic activ Dr. Bonelli provides clinical super- The Molecular Mechanism ity, using chemical and state-of-the- vision to resident physicians at the of Transducin Activation art instrumental approaches. In other University Ophthalmology Associates The conversion of light energy into rod studies, Dr. Yuan and his colleagues and teaches medical students during cell impulse responses requires signal are identifying candidate enzymes in- their ophthalmology surgical subspe- transfer between a photoreceptor, volved in the putative secondary iso cialties clinical rotation. She is collab- rhodopsin, and a rod cell protein called merase pathway in cone dominant orating on a study to learn and better transducin. Dr. Van Eps is studying the species. Another research interest is understand giant cell arteritis (GCA), structural changes in transducin that elucidating the biochemistry of ABCA4 an inflammation of the lining of the ar- are necessary for signal relay between protein in Stargardt disease and age- teries. GCA frequently causes blurred the two proteins. The techniques of related macular degeneration. or double vision and, if left untreated, site-directed spin labeling and electron may result in loss of vision. She is paramagnetic resonance are used also a co-investigator for the National to follow transducin conformational PROFESSIONAL CLINICAL Eye Institute-sponsored study of idio- changes that are important for its SERIES pathic intracranial hypertension. function and catalytic cycle. John D. Bartlett, MD Melissa W. Chun, OD Alejandra Young, PhD Assistant Clinical Professor of Ophthalmology Associate Clinical Professor Assistant Project Scientist of Ophthalmology Clinical Director, RESEARCH SUMMARY University Ophthalmology Associates Director of the UCLA Vision Rehabilitation Center Ocular Albinism Cataract Surgery Dr. Young’s research is focused in Dr. Bartlett provides clinical super- RESEARCH SUMMARY the study of the molecular mecha- vision to resident physicians at the Vision Rehabilitation nism of ocular albinism type 1 (OA1), University Ophthalmology Associates Dr. Chun’s clinical research interests a disease caused by mutations in the and teaches medical students during are in the areas of vision rehabili- OA1 gene and characterized by hypo their ophthalmology surgical subspe- tation outcomes and training tech- pigmentation of the retinal pigment cialties clinical rotation. He also is re- niques that maximize visual function. epithelium and abnormal crossing sponsible for the continued develop- She is a member of the Low Vision of the optic axons at the optic chi- ment of the resident cataract surgery Research Network, a nationwide col- asm. She is investigating the poten- educational curriculum. laboration of low vision specialists tial therapeutic use of engineered for multicenter clinical studies. She human embryonic stem cell-derived

78 Stein Eye Institute | Faculty is currently participating in the Low RESEARCH SUMMARY residents and fellows at both the Stein Vision Rehabilitation Outcomes Study, Thyroid Eye Disease, Eye Institute and Harbor-UCLA Medi- a multicenter pilot study that utilizes Ocular Surface Disease, and cal Center, where she heads the pedi- surveys and questionnaires to assess Eyelid Disorders atric ophthalmology service. Dr. Khitri outcome and effectiveness of low vi- is also actively involved with the UCLA sion rehabilitation. Dr. Hwang’s research includes studies Mobile Eye Clinic, bringing high quali- involving thyroid eye disease (Graves ty eye care to children with otherwise disease), ocular surface disease, and poor access to ophthalmic providers. Rachel Feit-Leichman, MD eyelid disorders such as blepharospasm. Dr. Hwang has a dedicated Associate Physician Diplomate thyroid eye disease clinic to investigate Tania Onclinx, MD Cataract Surgery the clinical course of the disease and Clinical Instructor of Ophthalmology treatments, as well as to provide ed- Dr. Feit-Leichman divides her time ucation and patient support. The clinic Associate Physician Diplomate between supervising residents and is the first in the country to provide providing patient care at the Stein Eye an orbital specialist, Dr. Hwang, and RESEARCH SUMMARY Institute’s Urgent Care Clinic, Univer- a rheumatologist, Dr. Ben-Artzi, who sity Ophthalmology Associates; and Urgent Care and work together to evaluate and treat teaching cataract surgery and over- Clinical Supervision patients affected with thyroid eye seeing residents at the ophthalmol- Dr. Onclinx attends at the Urgent Care disease. Dr. Hwang will be starting a ogy clinic of the Harbor-UCLA Med- Walk-In service at the Stein Eye Insti- blepharospasm clinic in order to better ical Center. Dr. Feit-Leichman is also tute. She teaches resident physicians educate patients, form support groups, active in striving to improve patient and medical students at the Universi- and aid in clinical studies. In addition, access to eye care in the greater Los ty Ophthalmology Associates during Dr. Hwang collaborates with research- Angeles County Healthcare System. their subspecialty clinical rotation. She ers from other departments, such as also provides clinical supervision to interventional radiology and head and resident physicians at Ronald Reagan neck surgery, on various projects. Karen Hendler, MD UCLA Medical Center and UCLA Med Clinical Instructor of Ophthalmology ical Center, Santa Monica. Batool Jafri, MD RESEARCH SUMMARY Associate Physician Diplomate UCLA Mobile Eye Clinic Susan S. Ransome, MD Assistant Clinical Professor Associate Physician Diplomate Dr. Hendler works with the UCLA of Ophthalmology mobile eye clinic providing services Clinical Instructor of Ophthalmology to the underserved children of Los RESEARCH SUMMARY RESEARCH SUMMARY Angeles County as part of the Center Cornea/External Disease/ for Community Outreach and Policy Refractive Surgery Cytomegalovirus Retinitis at UCLA. The goal is to determine Dr. Ransome is participating in sever- the need for prescriptive lenses in Dr. Jafri provides patient care as well as supervision to resident physicians al clinical research studies involving preschool children and to detect the HIV-infected patients, some of whom presence of amblyopia or other eye and cornea fellows at the Stein Eye In- stitute. Her focus is medical and surgi- have AIDS and cytomegalovirus reti- conditions or diseases. Dr. Hendler nitis. In one study, investigators are is also participating in epidemiologic cal treatment of diseases of the cornea, external disease, and refractive condi- following patients over time to see studies on the outcome of screening what types of eye problems devel- of preschool children. tions like near and far sightedness. She also provides general ophthalmic care op in HIV-infected individuals in the and offers cataract surgery with pre era of potent antiretroviral therapies. mium intraocular lens implants. Dr. Ransome is also following pa- Catherine J. Hwang, MD, tients with HIV who have diabetes to MPH see whether there is increased risk Associate Physician Diplomate Monica R. Khitri, MD of development or progression of diabetic retinopathy when subjects are Assistant Clinical Professor Associate Physician Diplomate of Ophthalmology treated for abdominal lipodystrophy with Egrifta (tesamorelin). RESEARCH SUMMARY Pediatric Ophthalmic Diseases and Strabismus Dr. Khitri specializes in the evaluation and treatment of pediatric ophthalmic diseases as well as childhood and adult strabismus. She teaches

Faculty | Stein Eye Institute 79 Meryl L. Shapiro-Tuchin, MD STEIN EYE INSTITUTE Richard W. Young, PhD EMERITUS FACULTY Associate Physician Diplomate Professor of Neurobiology Emeritus Assistant Clinical Professor Dean Bok, PhD Member of the Stein Eye Institute of Ophthalmology Dolly Green Chair of Ophthalmology Director of the Ophthalmology Inpatient Consultation Service Professor of Ophthalmology Emeritus (Active Recall) Comprehensive Distinguished Research Professor Ophthalmology of Neurobiology Dr. Shapiro-Tuchin provides clinical su- Member of the pervision to resident physicians while Brain Research Institute they are attending patients at Univer- sity Ophthalmology Associates clinics. Member of the Stein Eye Institute She also functions as Director of the Ophthalmology Inpatient Consultation Michael O. Hall, PhD Service, assisting resident physicians in their evaluation of inpatients ad- Professor of Ophthalmology Emeritus mitted to the David Geffen School of Founding Member of the Medicine at UCLA. Stein Eye Institute

Mehryar “Ray” Taban, MD, Robert S. Hepler, MD FACS Professor of Ophthalmology Emeritus (Active Recall) Assistant Clinical Professor of Ophthalmology Founding Chief of the Neuro-Ophthalmology Division Associate Physician Diplomate Member of the Stein Eye Institute Aesthetic and Reconstructive Oculoplastic Surgery Dr. Taban provides clinical supervision Allan E. Kreiger, MD to resident physicians and oculoplas- Professor of Ophthalmology Emeritus tic fellows at the Stein Eye Institute. (Active Recall) He focuses on nonsurgical and surgi- Founding Chief of the Retina Division cal management of disorders of the eyelid, orbital, and lacrimal system. Bradley R. Straatsma, MD, JD Professor of Ophthalmology Emeritus (Active Recall) LECTURER Founding Chairman of the Kathleen L. Boldy, VMD Department of Ophthalmology Founding Director of the Lecturer in Ophthalmology Stein Eye Institute

Barry A. Weissman, OD, PhD Professor of Ophthalmology Emeritus (Active Recall)

Marc O. Yoshizumi, MD Professor of Ophthalmology Emeritus Member of the Stein Eye Institute

80 Stein Eye Institute | Faculty PROGRAMS Inpatient Consultation University Ophthalmology Patient Care Services Service Associates

The Institute’s program of care Stein Eye Institute–Westwood Comprehensive and subspecialty eye for patients encompasses the full The Ophthalmology Inpatient Consul care in all medical and surgical areas range of eye diseases. Nationally tation Service, operating 24 hours a of ophthalmology is offered through and internationally renowned fac day through the Ronald Reagan UCLA University Ophthalmology Associates. ulty, along with highly skilled clini Medical Center, provides consultation Dr. John D. Bartlett is medical direc cal fellows and physician residents, and treatment to pediatric and adult tor, and ophthalmologists who are provide integrated consultation and patients admitted to the hospital’s members of the UCLA Medical Group treatment, including new diagnos staff the practice. tic and therapeutic procedures that medical, surgical, and psychiatric in have been made available through patient services. Led by Dr. Meryl Stein Eye Institute, Westwood recent scientific advances. Institute L. Shapiro-Tuchin, the consultation 100 Stein Plaza, UCLA ophthalmologists are supported in team consists of physician-residents. Los Angeles, CA 90095 their efforts by skilled optometrists, Subspecialty coverage from faculty is Referral Service: (310) 794-9770 orthoptists, technicians, and nurses. provided as needed. Emergency Service: (310) 825-3090 Care is delivered in distinctive sub After-Hours Emergency Service: specialty treatment centers, service Stein Eye Center–Santa Monica areas, and clinical laboratories, as (310) 825-2111 well as in specially equipped oph The Ophthalmology Inpatient Consul thalmic surgical suites and a dedi tation Service, operating through the cated inpatient unit. In addition, the Stein Eye Center–Santa Monica, pro Stein Eye Center– Stein Eye Center–Santa Monica and vides consultation and treatment to Santa Monica the Doheny Eye Centers UCLA offer pediatric and adult patients admitted The Stein Eye Center, under the direc premier eye care services in conve to the hospital’s medical, surgical, and tion of Dr. Colin A. McCannel, offers nient neighborhood locations. psychiatric inpatient services. Led by the world-renowned comprehensive Dr. Laura Bonelli, the consultation and subspecialty eye care of the Stein team consists of physician-residents. Eye Institute at a convenient location Subspecialty coverage from faculty is in Santa Monica. Established in 2011, provided as needed. the Stein Eye Center–Santa Monica Faculty Consultation Service features well-equipped exam rooms, an optical shop, convenient on-site Institute faculty members provide Surgical Services direct consultation and treatment, parking for easy access, and testing fa including emerging therapies, to pa Ophthalmic surgery of every varia cilities offering a wide range of exam tients through the Ophthalmology tion, from cataract extraction to re inations, including visual field, corneal Faculty Consultation Service. Faculty moval of ocular and orbital tumors, is mapping (corneal topography), intra members have extensive, advanced performed in the Institute’s dedicated ocular lens measurement, fluorescein training in ophthalmic subspecialties, operating rooms. Additionally, laser angiography, spectral domain optical providing referring physicians and pa vision-correction surgeries, such as coherence tomography, and other di tients with a valuable resource for laser-assisted in situ keratomileusis agnostic retinal imaging techniques. special eye problems. (LASIK) and certain aesthetic and Nearly all the evaluation, diagnosis, retinal laser surgeries and injection testing, and treatment services avail procedures, are performed in desig able at the Stein Eye Institute in nated outpatient procedure rooms. Westwood are offered at the Stein Faculty members perform surgical Eye Center–Santa Monica, by experts procedures according to their specific in retinal disorders, corneal disorders, ophthalmic specialty. They are joined glaucoma, neuro-ophthalmology, and by other medical specialists, including laser refraction surgery. For surgeries anesthesiologists, nurses, and tech and seldom-needed tests requiring nicians to ensure the highest quality specialized laboratories, patients can preoperative and postoperative care. be referred to the Institute’s main fa cility in Westwood.

Stein Eye Center–Santa Monica 1807 Wilshire Boulevard, Suite 203 Santa Monica, CA 90403 Telephone: (310) 829-0160 Fax: (310) 829-0170

82 Stein Eye Institute | Patient Care Services Doheny Eye Center UCLA– Doheny Eye Center UCLA– Doheny Eye Centers UCLA Orange County Pasadena The UCLA Department of Ophthal The Doheny Eye Center UCLA– The Doheny Eye Center UCLA– mology and the Doheny Eye Institute Orange County opened on May 15, Pasadena, which opened on July 1, formed a historic affiliation in 2014, 2014, in the Orange Coast Memorial 2014, serves as the primary hub of the and patient access to eye care was Medical Center, broadening the reach Doheny Eye Centers UCLA. Located immediately broadened across Los of the UCLA Department of Ophthal on the second floor of the Hunting Angeles and into Orange County, mology south to Orange County. ton Pavilion, the Doheny Eye Center with the opening of three Doheny UCLA–Pasadena provides expanded Newly renovated, the Orange County Eye Center UCLA locations: Arcadia, vision care services and clinics devot location, overseen by Medical Direc Orange County, and Pasadena. The ed to retina and cornea; comprehen tor , offers com Doheny and Stein Eye Institutes share Dr. Brian A. Francis sive ophthalmology and oculoplastics; prehensive ophthalmology, as well as a long tradition of excellence, and neuro-ophthalmology; and glaucoma. glaucoma, retina, and cornea subspe through this partnership, the respec Each subspecialty clinic has dedicat cialty services. The Doheny Eye Cen tive strengths that gained each Insti ed, state-of-the-art diagnostic laser ter UCLA–Orange County includes 12 tute an international reputation have suites, as well as in-office procedure exam rooms, dedicated diagnostic been combined. The board-certified rooms. More complex procedures are equipment, and inviting patient areas. Doheny ophthalmologists that pa performed at the Huntington Pavilion tients and referring physicians know Doheny Eye Center UCLA– Surgical Suites, which are located on and trust are now members of the Orange County the building’s third floor. UCLA Department of Ophthalmology. Orange Coast Memorial The Doheny Eye Centers UCLA are The Huntington Pavilion is home to a Medical Center under the direction of Vice Chairman wide variety of medical practitioners, 18111 Brookhurst St., Suite 6400 Dr. Alfredo A. Sadun, and Medical which provides physicians with ease Fountain Valley, CA 92708 Director Dr. John A. Irvine. of referral for patients requiring spe Telephone: (714) 963-1444 cialized eye care and provides pa Fax: (714) 963-1234 Doheny Eye Center UCLA– tients with the added convenience of Arcadia seeing their doctors and having any As Medical Director of the Doheny Eye necessary services all in one location. Center UCLA–Arcadia, Dr. Kenneth L. The Medical Director of the Doheny Lu oversees a renovated office that Eye Center UCLA–Pasadena is Dr. includes 12 exam rooms, dedicated Vikas Chopra. diagnostic equipment, and attractive Doheny Eye Center UCLA–Pasadena patient areas. The Center provides Huntington Pavilion comprehensive ophthalmology, and 625 S. Fair Oaks Blvd., 2nd Floor nearly all subspecialty services, includ Pasadena, CA 91105 ing glaucoma, retina, and cornea. Telephone: (626) 817-4747 The Doheny Eye Center UCLA– Fax: (626) 817-4748 Arcadia, which opened April 1, 2014, serves patients in the broader Arcadia region and San Gabriel area, expand ing the UCLA Department of Oph thalmology’s reach in Los Angeles County. The Arcadia Center is easily accessible from two freeways and provides on-site, free parking.

Doheny Eye Center UCLA–Arcadia 622 W. Duarte Road, Suite 101 Arcadia, CA 91007 Telephone: (626) 254-9010 Fax: (626) 254-9019

Patient Care Services | Stein Eye Institute 83 Summary of Patient Care Statistics Center for Community 2012–2013 2013–2014 Outreach and Policy

Faculty Consultation Service The Stein Eye Institute’s Center for Patient visits 89,186 Community Outreach and Policy, under the direction of Dr. Anne L. University Ophthalmology Associates Coleman, is dedicated to the prin Patient visits 22,398 ciple that all individuals deserve the Inpatient Consultation Service best vision attainable. Building upon Patient evaluations 704 the Institute’s long tradition of com Clinical Laboratories munity service and leadership at the Procedures 37,811 interface of ophthalmology and public health, the Center conducts vital re Surgery Services search in public -health ophthalmology Number of procedures 16,188 through the UCLA Center for Eye Ep Mobile Eye Clinic idemiology and provides high-impact Number of patients seen 12,990 community-based services, such as Ocular abnormalities 17% the UCLA Mobile Eye Clinic. Number of trips 190

*Includes screenings of special program UCLA Center for Eye Epidemiology The UCLA Center for Eye Epidemiol ogy was established in 1997 to pro mote interdisciplinary investigations Aesthetic Center into blinding diseases of public health Research and Treatment The Aesthetic Center, under the di importance. It is supported by private Research and donations, including an endowment TreatmentCenters Centers rection of Dr. Robert Alan Goldberg , provides services to patients who are established by The Ahmanson Foun dation. The Center maintains and im The Ophthalmology Treatment Cen interested in enhancing their appear The Ophthalmology Treatment Cen proves vision health through public ters provide subspecialty care from ance through aesthetic surgery. Drs. ters provide subspecialty care from health research and intervention, and faculty physicians who are actively Catherine J. Hwang and Daniel involved in related research, en Rootman also see patients. Estab serves as a coordinating body for ex involved in related research, en panding and sharing information. abling emerging and experimental lished in 1998, the Center has earned treatment options to be developed treatment options to be developed a reputation for high quality, individual Center members have expertise in epi for a gamut of eye disorders. In ad for a gamut of eye disorders. In ad ized care delivered by surgeons trained demiology, biostatistics, health policy, dition to comprehensive treatment, in both ophthalmic and plastic surgery. the centers provide both patients public health, and international health. the Centers provide both patients Members draw on their diverse back and physicians with expert diag Surgical services include upper and grounds and complementary skills to nostic and consultation services for lower eyelid blepharoplasty, endo diseases that are difficult to identi scopic forehead lifting, endoscopic promote an understanding of issues fy and treat. Ophthalmology faculty midface surgery, lifting of the neck related to vision health as it affects work closely with other specialists, work closely with other specialists, and face, liposuction, fat transfer, and individuals, communities, and society. both within the Stein Eye Institute both within the Stein Eye Institute skin treatment, as well as dermal fill The Center encourages collaborative and in other UCLA clinical depart research among faculty and inves ments, to create a multidisciplinary er and other cosmetic injections to ments, to create a multidisciplinary smooth facial lines. Minimally invasive tigators from various UCLA depart team customized for each patient’s approaches are utilized to provide the ments and other institutions around unique medical needs. optimal aesthetic result. A major goal the world to advance knowledge re of the Center is to conduct research lated to the causes and prevention of focused on improving understanding specific eye diseases. of facial aging, surgical healing, and on developing new techniques for aesthetic surgery. Center physicians have pioneered minimal incision sur gical techniques to enhance the nor mal function and appearance of the eyes and face, and often receive re ferrals for complex and reoperative plastic surgery cases.

84 Stein Eye Institute | Research and Treatment Centers UCLA Mobile Eye Clinic completed a study showing its ef studies. This support involves vital, fectiveness in treating corneal ulcers behind-the-scenes activities that fa For more than 40 years, the UCLA that now blind more than 400,000 cilitate the clinical research process. Mobile Eye Clinic has supported pa children worldwide. A second study, Dr. Gary N. Holland serves as direc tient care and screening programs in which evaluated the solution’s effec tor of the CRC; additional members of neighborhoods where poverty and tiveness in treating fungal corneal the Board of Directors during 2013–14 vision disabilities intersect. The dedi infections, a major cause of pediatric included Drs. Joseph Caprioli, Mi- cation and hard work of UCLA Mobile blindness in tropical countries, has chael B. Gorin, Ralph D. Levinson, Eye Clinic ophthalmologists, techni shown promise in treating the milder and Steven D. Schwartz. The CRC cians, and volunteers have touched fungal infections. has a full-time administrator, Ms. El- the lives of hundreds of thousands len Haupt, and an in-house statisti of individuals. cian, Fei Yu, PhD. CRC staff mem The UCLA Mobile Eye Clinic, a 39- Center for Regenerative bers interact with granting agencies foot-long bus specially outfitted with Medicine in Ophthalmology and government regulatory bodies, eye examination equipment, is sup Representing a milestone in the thera assist with the preparation of grant ported by charitable contributions to peutic use of stem cells, in 2011, Stein applications, participate in the design the Stein Eye Institute. The UCLA Eye Institute clinician-scientists suc and management of clinical studies, Mobile Eye Clinic’s staff of trained cessfully transplanted the first human and perform data collection and anal ophthalmic personnel provides gen embryonic stem-cell-derived retinal ysis functions. eral eye care to over 4,000 under pigment epithelial cells into the eyes Institute faculty members are cur served adults and children annually of legally blind patients with Stargardt rently conducting more than 70 clin throughout Southern California. Ser disease and dry macular degeneration. ical research studies (listed in the Ap vices include ophthalmic examination pendices). Patients can volunteer to and refraction, diagnosis of potential The Center for Regenerative Medicine participate in studies that contribute or existing eye disorders, treatment in Ophthalmology (CRMO), under the to a better understanding of ocular of some ocular diseases, and appro co-direction of Drs. Sophie X. Deng disorders or that evaluate new, po priate referral of patients who need and Gabriel H. Travis, is building tentially better treatments for various additional care. upon these efforts, using stem cells for the treatment of corneal disorders diseases of the eye. and retinal degenerative diseases. The Center to Prevent CRMO fosters collaboration between Contact Lens Center Childhood Blindness basic scientists and clinicians, includ ing Drs. Debora Farber, Jean-Pierre The Contact Lens Center, under the The Center to Prevent Childhood Hubschman, Steven Schwartz, and supervision of Dr. Vivian A. Phan, Blindness, under the direction of Dr. Xian-Jie Yang, to translate advances serves patients with all ophthalmic di Sherwin J. Isenberg, is committed in basic science research into new agnoses that can be treated with con to reducing pediatric blindness. UCLA and improved clinical therapies. tact lenses. The Center’s primary focus physicians and basic scientists, in is on customized specialty lenses that cluding Drs. Gary N. Holland, Ste- Many of the blinding eye diseases, in visually rehabilitate conditions, such ven Nusinowitz, and Irwin Weiss, cluding glaucoma, macular degenera as keratoconus, corneal transplants, collaborate on research, education, tion, and corneal diseases, are due to corneal scarring, postrefractive surgery and patient care programs designed the loss of functional tissue. The devel ectasia, ocular surface disease, and to increase awareness and help treat opment of effective and safe individu aphakia. Dr. Phan also prescribes con pediatric blindness. Significant em alized stem-cell-based therapies relies tact lenses to address farsightedness, phasis is on the development and on robust basic science, translation- nearsightedness, and presbyopia. evaluation of ophthalmic medical and al, and clinical research. The CRMO surgical options for children. supports current stem cell studies and The specialty lenses that are avail- pursues new research programs to di able through the Contact Lens Cen Center members are developing a agnose, treat, and ultimately cure and ter include rigid gas permeable con new noninvasive method of mea prevent blinding eye diseases. tact lenses, multifocal contact lenses, suring blood gases from the surface hybrid lenses, scleral lenses, custom of the eye, which may be critical in soft lenses, soft lenses for irregu preventing retinopathy of prematurity, Clinical Research Center lar corneas, prosthetic soft lenses, a leading cause of blindness in pre pediatric aphakic lenses, and adult mature newborns. In another avenue The UCLA Department of Ophthalmol aphakic lenses. of research, the Center developed ogy Clinical Research Center (CRC) an extremely inexpensive antiseptic was established in 1998 to provide Dr. Phan’s clinical research is focused solution to treat pediatric corneal core support to faculty members who on keratoconus and scleral lenses infections in developing areas, and are conducting patient-based research for the treatment of ocular surface

Research and Treatment Centers | Stein Eye Institute 85 disease. A large majority of her pa ocular trauma within the UCLA hospi Stein Eye Institute researchers, Drs. tients require custom contact lenses tal system, including support to affili Anne L. Coleman, JoAnn A. Giacone , and are referred by corneal specialists. ated institutions. Jacky M. K. Kwong, Simon K. Law, Kouros Nouri-Mahdavi, and Natik Patients are commonly referred to Piri, are working with researchers and the Center for such ocular traumas Diabetic Eye Disease and statisticians from the UCLA School of as ruptured globe, intraocular foreign Retinal Vascular Center Public Health to identify individuals at bodies, acute orbital hypertension, greatest risk for vision loss, to devel Under the direction of Dr. Steven D. retinal detachment, chemical burns op and assess therapeutic strategies, Schwartz, the Diabetic Eye Disease of the cornea and conjunctiva, and and to implement new treatments and Retinal Vascular Center provides acute vitreous hemorrhage. The Cen to preserve vision. diabetic patients with comprehensive ter offers complete evaluation and ophthalmic care. Established more treatment of the traumatically injured than a decade ago, the Center has eye, including vitreoretinal and/or or UCLA Laser Refractive Center contributed significantly to the under bital and ophthalmic plastic surgery, standing, treatment, and prevention anterior segment surgery, and medi The UCLA Laser Refractive Center is of diabetic eye disease. Current focus cal follow up. Expertise is provided for under the direction of Dr. David Rex is on innovation in technologies and both urgent primary repair and sched Hamilton. Founded in 1991, the Cen techniques that expand the standard uled secondary repair. ter specializes in refractive surgery of of treatment, such as new lasers and both the cornea and lens of the eye, laser strategies, refinement of micro including clinical and research appli surgical techniques specific to diabet Gerald Oppenheimer Family cations of new laser technology. The ic eye diseases, and nontraditional Foundation Center for the Center is one of a few in the United treatment approaches. Prevention of Eye Disease States to pioneer investigations into laser eye surgery. The Center’s treatment philosophy is Established with a generous pledge based upon the systemic nature of from Gail and Gerald H. Oppenheimer, The UCLA Laser Refractive Center of diabetes. Patient care is coordinated the Gerald Oppenheimer Family Foun fers all cornea refractive procedures, with other UCLA departments to ad dation Center for the Prevention of Eye including LASIK and LASEK/PRK, astig- dress the special needs of diabetics Disease is committed to the discov matic keratotomy, conductive kerato that lie outside the field of ophthal ery of agents and methods to prevent plasty, and intracorneal ring implanta mology. Center treatment interven ophthalmic diseases. Areas of study tion. Advanced intraocular lens (IOL) tions include laser and ophthalmic supported by the Foundation include procedures are also available, includ surgery. Recognizing the special care genetic and environmental factors that ing presbyopia-correcting IOLs (multi needed for diabetics in any surgical may cause eye disease, and pharmaco focal and accommodating), toric IOLs, situation, Center physicians perform logic and natural agents to prevent eye and phakic IOLs. Patients referred to all eye surgeries for diabetics, includ disease. The Center complements an the Center undergo a complete ocu ing those specific to the disease, as expanding array of research in many lar examination that includes corneal well as vitrectomy, cataract surgery, other fields at UCLA, where rigorous topographic mapping, wavefront anal and retinal reattachment. scientific methods are being applied to ysis, and corneal biomechanical mea study novel approaches to health care. surements to identify conditions that may interfere with surgical correction Eye Trauma and of refractive errors. Candidates for la Emergency Center Glaucoma Center ser or intraocular lens surgery receive for Excellence in The Eye Trauma and Emergency Cen intensive education to understand the Care and Research ter, under the direction of Dr. Robert benefits, risks, and alternatives to sur Alan Goldberg, provides immediate In the United States, glaucoma is the gery. Participation in clinical trials for response to ophthalmic emergencies second cause of irreversible legal new refractive devices and techniques through an eye trauma team avail blindness. If glaucoma is detected ear to treat nearsightedness, farsighted able 24 hours a day for consultative, ly, however, vision loss can be slowed ness, and presbyopia may be an op medical, and surgical care involving or even prevented. Under the direc tion for qualified patients. For more both primary and secondary ocular tion of Dr. Joseph Caprioli, the Glau information about the UCLA Laser Re repairs. Ophthalmic emergency care coma Center for Excellence in Care fractive Center, go to: www.uclaser. has been provided by the UCLA De and Research is committed to giving com and lasik.ucla.edu. partment of Ophthalmology since its each patient a chance for a brighter inception. In 1980, the Eye Trauma future and a life filled with sight. and Emergency Center was formally established to encompass all levels of

86 Stein Eye Institute | Research and Treatment Centers Center faculty members were the Macular Disease Center first to describe cytomegalovirus ret Optic Neuropathy Center The Macular Disease Center, under the initis as an ophthalmic manifestation Under the direction of Dr. Anthony direction of Dr. Steven D. Schwartz, of AIDS; today the Center is a na C. Arnold, the Optic Neuropathy Cen was created in 1994 in response to the tionally recognized site of expertise ter provides multidisciplinary consul growing national incidence of macu- for AIDS-related ophthalmic disease. tation, diagnosis, and treatment for lar degeneration. The Center’s mis Other special clinical and research patients with complex diseases in sion is threefold: provide high-quality programs have been developed in the volving the optic nerve. Established patient care, utilizing standard and de following areas: ocular toxoplasmosis, in 1991, the Center incorporates spe veloping treatments; offer associated uveitis in children, birdshot chorioret cialized facilities and equipment for rehabilitation services, such as low- inopathy, immunogenetics of inflam diagnostic testing and offers consul vision aids and counseling, in order matory eye diseases, unusual corneal tation from neuro-ophthalmologists, to enhance quality of life for patients; infections, and mediators of intraocu orbital surgeons, neurologists, neuro and promote collaborative translation lar inflammation. radiologists, and neurosurgeons. al research between clinicians and ba Patients referred to the Optic Neurop sic science researchers into the cause athy Center receive advanced diag of macular disease. Ophthalmic Oncology Center nostic testing of the orbit and optic Patients with the atrophic or dry form The Ophthalmic Oncology Center, nerve to assist in evaluation. Extensive of macular disease are evaluated and under the direction of Dr. Tara A. analysis of diagnostic data, together often considered for clinical trials, such McCannel, is renowned for its exper with information from the patient’s as the stem cell programs, and their tise in teaching, research, and clinical medical history and comprehensive cases are followed at the Macular management of adult posterior seg physical examination, enables Center Disease Center in conjunction with ment tumors. Established in the early physicians to determine the nature of services offered by the Vision Re 1980s by the Institute’s Founding Di the disease and devise a treatment habilitation Center. Patients with the rector, Dr. Bradley R. Straatsma, the plan. Treatment may be medical or exudative or wet form of macular dis Center is internationally recognized surgical depending on the nature of ease are diagnosed and treated with for the diagnosis and management of the referral and the patient’s disease cutting-edge therapies. Treatment op ocular melanoma. The Center serves status. As part of the Center’s clinical tions for wet macular disease include as a hub for national, long-term studies research effort, physicians are refin therapy and participation in clinical investigating ocular melanoma, and ing disease classifications along with studies that are matched to the pa played an important role in the Collab diagnostic and treatment approaches tient’s disease status. A patient coor orative Ocular Melanoma Study spon to further the field of optic neuropathy dinator is available to answer ques sored by the National Eye Institute. and improve options for patients with tions and provide information on an The Center’s clinical goal is success these complex disorders. ongoing basis. ful treatment of the primary eye tu mor. Patients diagnosed with ocular melanoma may be offered highly so Orbital Disease Center Ocular Inflammatory phisticated treatment plans coordinat The Orbital Disease Center, under the Disease Center ed with UCLA radiation physicists and direction of Dr. Robert Alan Gold- The Ocular Inflammatory Disease radiation oncologists. Patients may berg, was founded in 1991. The Cen Center, under the direction of Dr. also qualify to participate in clinical ter brings multidisciplinary expertise Gary N. Holland, was established in research studies in partnership with to the treatment and study of orbital 1985 to coordinate research, educa the UCLA Jonsson Comprehensive diseases arising from trauma, cancer, tional activities, and patient-care ser Cancer Center. The Center’s primary inflammation, and infection. Care is vices related to a broad spectrum of research goal is to gain a fundamental organized around a team of experts in inflammatory eye disorders, including understanding of the molecular biolo ophthalmology, neuroradiology, neuro uveitis, infectious corneal ulcers, en gy of metastatic ocular melanoma. In surgery, head and neck surgery, radi- dophthalmitis, autoimmune diseases addition to providing genetic prognos ation oncology, and craniofacial sur of the cornea and ocular surface, and tic information to patients on their risk gery, bringing to the treatment of the ophthalmic manifestations of HIV of tumor metastasis, the Center has orbital diseases a depth of knowledge disease. The Center has a long history identified key genes associated with and experience not available else of participating in clinical studies and metastatic tumors. where in Southern California. drug-therapy trials that have furthered the understanding and treatment of these diseases.

Research and Treatment Centers | Stein Eye Institute 87 The Center provides both medical and surgical management of orbital Vision Proteomics Center Vision Rehabilitation Center diseases. The team performs proce Genes encode the sequences of pro The Vision Rehabilitation Center, un dures that are not usually available in teins, and knowledge of the struc der the direction of Dr. Melissa W. the community, including orbital de ture and function of these proteins Chun with Dr. Steven D. Schwartz compression microsurgery for orbital is required to unlock the secrets of as medical advisor, was established apical tumors, optic canal decompres the cell. That task is now set before to provide rehabilitation to maximize sion, combined interventional neuro current and future generations of visual function and quality of life of pa radiology procedures for vascular scientists, and a new field of study, tients with low vision, defined as best tumors, and bony reconstruction to Proteomics, has been born. It is only corrected vision of 20/70 or worse address traumatic or congenital de through an understanding of protein in the better eye. These outcomes fects. The Center has an active pro function at the molecular level that are accomplished with a rehabilitation gram in thyroid eye disease, where researchers can learn the fundamen plan tailored to each patient’s specific new surgical techniques are evalu tal origins of disease and develop ra needs and goals. ated, and basic science research is tional therapeutic designs to correct The Center provides assistance in the carried out to advance understanding defects in the molecular machinery. about the disease. form of patient consultation and train The Vision Proteomics Center at the ing, including reading and computer Stein Eye Institute, under the direc training, as well as evaluation with Vision Genetics Center tion of Dr. Wayne L. Hubbell, with re the latest low-vision devices that can searchers Drs. Ben J. Glasgow, Dean help patients adapt to their visual re Initially established in 1978 as the Bok, Joseph Horwitz, and Gabriel strictions. The Center utilizes a wide UCLA Retinitis Pigmentosa Registry, H. Travis, has pioneered the develop array of technologically advanced de the Vision Genetics Center, under the ment of site-directed spin labeling–– vices, such as magnifiers, telescopes, direction of Dr. Michael B. Gorin, is the only one of its kind in the world, and digital and computer technology. an integrated clinical and research ushering in a new era of exploration Customized for each patient’s individ program that addresses the full spec of structure/function relationships in ual needs, services may range from trum of hereditary eye disorders. Cen proteins. Research groups at the Stein simple solutions to specialized ap ter members, representing multiple Eye Institute, departments at UCLA, proaches. One unique feature of the disciplines, combine their efforts to and other major institutions through Center is a special “lending library” of understand the underlying molecular out the United States and abroad, select low-vision devices that enables basis of a broad range of ocular con are taking advantage of the singular patients to try devices at home or in ditions, including those involving the opportunities provided by the Vision the office prior to purchase. When development of the eye, cornea, lens, Proteomics Center. appropriate, referrals are provided to extraocular muscles, retina, vitreous, assist independent living through oc and optic nerve. Areas of interest cupational therapy and orientation and include both simple inherited condi mobility training. tions caused by alterations in single genes, as well as conditions in which multiple genetic variations and other risk factors play a role. The Center offers patients and their family members state-of-the-art di agnosis and care of the hereditary eye or vision condition. Services in clude genetic counseling, and when appropriate, DNA testing either as a clinical diagnostic service, a research program, or in combination. The Cen ter’s faculty members collaborate with a number of genetic research groups around the world to ensure that patients can participate in the most advanced research for their particular condition.

88 Stein Eye Institute | Research and Treatment Centers Glaucoma Photography Ophthalmic Photography Clinical Laboratories Laboratory Clinical Laboratory

The Ophthalmology Clinical Labo The Glaucoma Photography Laborato The Ophthalmic Photography Clini ratories provide precise measure ry, under the direction of Dr. Joseph cal Laboratory, under the direction of ments, photographs, and quanti Caprioli, provides specialized photo Dr. Tara A. McCannel, provides a tative studies of the eye and the graphs for new and follow-up patients wide array of photographic techniques visual system. Quantitative infor to assist the ophthalmologist in the important in patient care, research, mation of this type enhances pa management of patients with glau and teaching. The primary purpose tient care by increasing the accura coma. The GDX Nerve Fiber Analyzer of ophthalmic photography in patient cy of diagnosis and enlarging the utilizes polarized light in place of dila care is to record the present state of parameters employed to assess the tion to measure the thickness of the the eye, and in cases of abnormality, clinical course and effectiveness of nerve fiber layer. This test is partic to establish a baseline and monitor the treatment. Additionally, the clini cal laboratories expand the scope ularly useful in diagnosing new glau patient’s condition over time. Patient of treatment alternatives, promote coma. Heidelberg retinal tomography, care services include photographic clinical research, and generally using confocal laser light, measures ad documentation of anterior segment augment the effectiveness of oph ditional parameters of the optic nerve diseases involving corneal problems thalmic disease management. The and provides more information on the like growths, infection, and trauma; laboratories are available to all oph nerve fiber layer. Optical coherence photographs of ocular motility to re thalmologists in the community. tomography utilizes reflected light to cord abnormalities in eye movement; measure the nerve fiber layer as well fundus photography, which captures as to measure macular holes as a pictures of the retina; and diagnostic staging procedure for surgical repair. testing using fluorescein and indo An ophthalmic fundus camera photo cyanine green angiography, which re Corneal graphs the optic nerve in stereo. The cords the dynamics of blood flow in Diagnostic Laboratory Laboratory is conducting clinical stud the eye. The Laboratory also supports ies to evaluate the effectiveness of the research and teaching activities of The Corneal Diagnostic Laboratory, each photographic modality in terms the Stein Eye Institute by preparing under the direction of Dr. Anthony J. of predictive accuracy and early de and duplicating graphic materials for , offers a comprehensive array Aldave tection of glaucoma. presentation and publication. of corneal imaging modalities. Ser vices include imaging of the anterior and posterior corneal surfaces with Ocular Motility Clinical and Ophthalmic Ultrasonography the Marco OPD-Scan III and Bausch Basic Science Laboratory Clinical Laboratory and Lomb Orbscan topographers and the Ziemer GALILEI Dual Sc heimpflug The Ocular Motility Clinical and Basic The Ophthalmic Ultrasonography Clini- Analyzer, and imaging of the cor- Science Laboratory, under the direc cal Laboratory, directed by Dr. Steven neal endothelium for assessment of tion of Dr. Joseph L. Demer, records D. Schwartz, performs clinical exam corneal endothelial cell morphology and quantitatively analyzes eye move inations that are useful in diagnosing and density using the KONAN Cell ment abnormalities resulting from oc both ocular and orbital eye diseases. Chek XL specular microscope. Full- ular and neurological disorders, such Diagnostic examinations include stan- thickness confocal microscopic im as ocular myasthenia gravis. Sever- dardized A-scan, B-scan, and bio aging of the cornea, a useful tool in al types of tests are performed. The microscopy. Standardized A-scan is the diagnosis of suspected fungal, Hess test utilizes specialized eye useful in tissue differentiation and acanthamoebic, and other parasitic charts and lenses to assist in the di is commonly employed to diagnose infections of the cornea, is performed agnosis of a number of problems, in ocular and orbital tumors, including with the Heidelberg HRT3 confocal cluding double vision. Magnetic scler choroidal melanoma. B-scan provides microscope. This instrument can also al search coil techniques are utilized location and contour information and perform optical pachymetry to non in clinical research studies to detect is particularly useful in differentiat invasively measure LASIK residual fine movements not evident through ing vitreous membranes from retinal bed thicknesses and flap thicknesses normal visual examination. Another detachment. Ultrasound biomicros as well as evaluate the LASIK inter test involves the visual recording of copy provides exquisitely detailed, face for possible infections, diffuse eye movement using a video cam- high-resolution views of the anterior lamellar keratitis, and ingrowth. era. The Laboratory also engages in segment of the eye and is a critical basic science research to further un- tool for the evaluation of ocular pa derstanding of eye movement, as well thology, especially in opaque corneas. as diseases of the eye, brain, and muscles, and related tissues of the inner ear.

Clinical Laboratories | Stein Eye Institute 89 Biometry and intraocular lens calcula record electrical signals from different tions are also performed in the Lab layers of the visual system to identify oratory, under the direction of Dr. the site responsible for visual symp Ralph Levinson. Biometry measures toms. Psychophysical tests require the the axial eye length, anterior chamber participation of the patient in specific depth, and lens thickness; intraocular tasks to evaluate visual functions like lens calculations are performed to de color blindness, contrast sensitivity, termine the power of the lens implant and visual acuity. In many cases, both for cataract patients. electrophysical and psychophysical tests are performed together to ob tain the optimum amount of informa Perimetry Laboratory tion for diagnosis. The Perimetry Laboratory, under the direction of Dr. Joseph Caprioli, per forms visual field examinations that determine the sensitivity of central and peripheral vision. Examinations are conducted with advanced Hum phrey automated perimetry equip ment. Testing detects visual field defi cits associated with certain kinds of eye diseases such as glaucoma, ret inal disorders, and neuro-ophthalmic conditions. Utilizing pinpoints of light around a perimetry bowl, the test eval uates different areas of the field of vision. Test results are computerized and compared to a range of normal values by age group. Patterns of di minished fields of vision are related to specific eye diseases. Perimetry testing is employed for diagnostic pur poses and to monitor visual field sensi tivity over time, especially for glaucoma patients. Both standard and shortwave automated techniques are available, in addition to frequency-doubling perim etry and motion-detection perimetry.

Visual Physiology Clinical Laboratory The Visual Physiology Clinical Lab oratory, under the direction of Drs. Michael B. Gorin and Steven Nusi nowitz, quantitatively evaluates the function of the retina and visual path ways. Patients are referred for func tional testing to confirm a specific diagnosis, or in cases where the eti ology is unknown, to rule out alter native diagnostic possibilities. Elec- trophysiological tests, including both the full-field and multifocal electro retinograms (ERG and mfERG), the electro-oculogram (EOG), and visual ly evoked cortical potentials (VECP),

90 Stein Eye Institute | Training Programs also attend several afternoon work ident has exposure to each medical Training Programs shops during which they learn eye center during the course of training, examination skills and treatments for thereby ensuring clinical experience The Stein Eye Institute and the eye problems that can be managed with a wide range of problems and pa UCLA Department of Ophthalmol by non-ophthalmologists. During their tient populations. Certification by the ogy jointly provide comprehensive third year of instruction, medical stu American Board of Ophthalmology is a training in ophthalmology and vi dents interested in additional training natural objective of the program. sion science to medical students, and experience can elect to spend two residents, and clinical and research weeks of their surgical clerkship on Clinical Rotations fellows. The programs encompass the Ophthalmology Service, examin Clinical rotations at the Stein Eye In the gamut of ophthalmic and vi- ing patients in clinic and observing eye stitute include both general ophthal sion science education, represent surgeries. During the fourth year of in ing every level of training and in mology and subspecialties. In gener struction, a series of advanced clinical corporating a full range of subjects al, ophthalmology residents work as a electives are available to medical stu in the study of the eye. The resi team, handling clinics, emergencies, dency program is rated one of the dents who plan eventually to practice and walk-in patients. They also serve top in the country. A large patient ophthalmology as their specialty. as an ophthalmology consult service population with diverse vision prob for inpatients in the UCLA Medical lems offers innumerable training Center. Residents assigned to subspe UCLA Medical Student opportunities for both residents and cialty service rotations are provided clinical fellows. The availability of Research Program with intensive exposure to the various more than 15 research laboratories At the Stein Eye Institute, medical stu divisions within the Department, work ensures a wide choice of vision sci ence projects for all trainees. Pre dents have taken laboratory and clin ing closely with faculty members in a doctoral and postdoctoral research ical research electives for decades, private practice environment. At the fellows particularly benefit from the however, there has been no formal UCLA-affiliated medical centers, resi wealth of new and unfolding re program wherein a medical student dents work in teams that provide both search generated by vision scien could obtain salary and research sup general and subspecialty patient care. tists at the Institute. port. The Medical Student Research Program allows select medical stu Didactic Education dents to familiarize themselves with Residents receive didactic education laboratory or clinical vision science in the classroom on an ongoing basis. research. Each year, a committee se- Once each week, all residents attend lects one or two medical student a mandatory half-day program that in researchers to receive salary and re cludes faculty lectures that, over the UCLA search support for six to 12 months in course of the three-year program, cov Medical Student Program the laboratory or clinical research area er each of the required subjects in the of the student’s mentor. The goal of Each academic year, the UCLA De American Academy of Ophthalmolo the program is to encourage medical partment of Ophthalmology and the gy Basic and Clinical Sciences Course. students to pursue careers in academ Institute extend instruction to UCLA These lectures are followed by Grand ic ophthalmology. medical students in their second, Rounds, which consist of presenta third, and fourth years of instruc tion and discussion of specific patient cases, and faculty lectures on clinical tion. Through lectures, small group UCLA Ophthalmology topics related to ophthalmic subspe discussions, and clinical experience, Residency Program all students have numerous training cialties. Throughout the week, clin sessions from which to gain knowl The Department of Ophthalmology ical conferences in ophthalmic sub edge about eye diseases and develop conducts an accredited three-year res specialties are held where problems eye examination skills that should be idency program for 24 residents; eight are presented and discussed. known by all physicians, regardless of new residents begin training each July. their specialties. Those students who The full breadth of ophthalmology train Surgery Training are interested in ophthalmology as a ing is offered, including experience in Residents begin to perform surgery in career have additional learning oppor general ophthalmology and ophthalmic their first year of training and continue tunities in elective courses. subspecialties. Training incorporates to operate throughout their residen the resources of the UCLA Stein Eye cy. Surgical cases are assigned com In their second year of instruction, Institute, Harbor-UCLA Medical Cen mensurate with level of training and all medical students attend a series ter, Olive View-UCLA Medical Center, experience. First-year residents begin of lectures covering various topics and the Veterans Affairs Greater Los in the Institute’s Microsurgery Labo related to eye diseases distributed Angeles Healthcare System at West ratory, an organized surgical course throughout their yearlong Human Bi Los Angeles and Sepulveda. Every res- that includes computerized surgical ology and Disease course. Students

Training Programs | Stein Eye Institute 91 simulators. This facility is available to ophthalmology, combining basic sci members who are engaged in basic residents throughout their training. ence with clinical practice in a five- science research and have active lab Residents first assist on selected sur year or six-year curriculum. EyeSTAR oratories. The scope and nature of the gical cases, and by the end of their graduates are trained to compete not training program for each predoctoral residency, they are performing proce just with clinical scientists but also or postdoctoral fellow is developed by dures independently. with top basic scientists from all in the trainee and his/her faculty mentor. stitutions. Trainees select their facul Research ty mentors from the Vision Research Fellowship in Cornea– External Ocular Diseases and An understanding of and an appreci Division of the Stein Eye Institute Refractive Surgery ation for research are major prerequi or from the David Geffen School of sites for assimilating future develop Medicine at UCLA, College of Let Under the direction of Drs. Anthony ments in ophthalmology. Accordingly, ters and Sciences, School of Public J. Aldave, Sophie X. Deng, David ophthalmic research is an integral com Health, Clinical Scholars Program, and Rex Hamilton, Kevin Miller, Bartly ponent of residency training. Residents RAND Graduate School. J. Mondino, and Rosalind Vo, one- year fellowships are offered in the are expected to undertake indepen EyeSTAR is recognized by the Nation study of diseases of the cornea, ex dent investigation or to participate al Eye Institute and the Association of ternal eye, anterior segment, and re in ongoing clinical or basic science University Professors of Ophthalmol fractive surgery. Clinical experience research projects in ophthalmology. ogy as a model training program for consists of participation in the cornea Residents present the results of their clinician-scientists in ophthalmology. work at the Stein Eye Institute Clini faculty practices, including surgery, cal and Research Seminar during their and in the care of emergency cornea second and third years of residency. UCLA Clinical Ophthalmology cases at the Stein Eye Institute. Fel They are also encouraged to report and Vision Science lows work in the microsurgical labora their studies at regional and nation Fellowship Programs tory, and assist in teaching microsurgi al meetings and publish their results cal skills to ophthalmology residents. The Stein Eye Institute offers particu in scientific journals. Residents with Under the direction of faculty, they larly well-qualified persons the oppor special clinical or research interests also perform primary surgical proce tunity to receive fellowship training in have an opportunity to use elective dures in the UCLA Laser Refractive specific areas of clinical ophthalmolo time to increase their exposure to Center. In addition to in-depth training gy or vision science research. a particular area of ophthalmology. at the Institute, fellows provide medi This time can be spent with full-time Following successful completion of a cal and surgical care to patients at the or volunteer faculty at UCLA or at residency program, a clinical fellow Veterans Affairs Greater Los Ange other institutions. ship combines outpatient, inpatient, les Healthcare System at West Los and surgical experience in an ophthal Angeles and Sepulveda and at Har mic subspecialty. The clinical fellow bor-UCLA Medical Center. Fellows EyeSTAR Program assumes increasing responsibility for typically complete an original clinical or laboratory research project, and fre For physicians who are interested in patient care under the supervision of quently co-author a book chapter or academic careers and professional faculty members responsible for the review during their training. leadership as clinician-scientists, the program. In addition to receiving train Stein Eye Institute offers an Ophthal ing from faculty, the fellow instructs Fellowship in Glaucoma mology Specialty Training and Ad medical students and residents. Re vanced Research Program, referred search is considered an important Under the direction of Drs. Joseph to as EyeSTAR, which offers vision aspect of specialty training and a Caprioli, Anne L. Coleman, JoAnn science training combined with an major prerequisite for assimilating A. Giaconi, Simon K. Law, and ophthalmology residency. Appointees future developments in ophthalmol Kouros Nouri-Mahdavi, the one- complete a residency program leading ogy. Clinical fellows are expected to year or two-year glaucoma fellow to certification in ophthalmology, as undertake independent investigation ship provides clinical and laboratory well as laboratory research experience or to participate in one of the ongoing experience in glaucoma diagnosis and leading to a doctorate, or postdoctoral research projects in a field related to management. Fellows gain clinical ex training in the event that the trainee their specialty. perience by examining patients in the already has a doctorate. EyeSTAR consultation suite and participating Vision science fellowship training is trainees work under the guidance of a in the clinical and surgical manage laboratory based and offers both pre faculty advisory panel representing the ment of patients. Fellows work in the doctoral and postdoctoral opportuni trainee’s clinical and research interests. Glaucoma Microsurgical Laboratory, ties to trainees in specific areas of vi participate in microsurgery courses, sion science that encompass a wide The unique program began in 1995 assist in the Glaucoma Clinic, and de- range of topics. Trainees work under and is geared to physicians com velop expertise in the various mitted to academic careers in the supervision of Institute faculty

92 Stein Eye Institute | Training Programs diagnostic techniques used in glaucoma and genetic retina. They are expected Fellowship in Orbital and treatment through preceptor-type re- to participate in genetic and imaging Ophthalmic Plastic Surgery lationships with faculty. Fellows par conferences as well as other rele- Fellowships in orbital and ophthal ticipate in glaucoma teaching at the vant meetings. mic plastic surgery, under the over Stein Eye Institute and affiliated in all supervision of Drs. Robert Alan stitutions, present cases at teaching Fellowship in Goldberg, Jonathan Hoenig, and rounds, and prepare presentations for Neuro-Ophthalmology Norman Shorr, provide training for regularly scheduled glaucoma confer The one-year fellowship in neuro- ophthalmologists who are interested ences. Fellows also undertake at least ophthalmology, under the direction in specializing in orbital and adnexal one research project, which may be of Dr. Anthony C. Arnold, involves disorders, and in aesthetic and recon a clinical study or an applied research a close preceptor-preceptee relation structive orbitofacial surgery. The fel project in the laboratory, in coopera ship, participation in teaching rounds, lowship program is approved by the tion with the faculty advisor. and work in the private consultation American Society of Ophthalmic Plas suite. The David Geffen School of tic and Reconstructive Surgery and Fellowship in Medical Retina Medicine at UCLA maintains major the American Academy of Cosmetic and Genetics clinical and research programs in Surgery. Fellows participate in orbital This one-year fellowship, under the neurology, neurosurgery, and neuro and ophthalmic plastic surgery out- directorship of Dr. Michael B. Gorin, radiology. Fellows attend the weekly patient consultation, inpatient care, provides clinical knowledge pertain Neurology and Neurosurgery Grand and surgical procedures at the Stein ing to the diagnosis and management Rounds, take an active part in see Eye Institute and affiliated hospitals. of a broad array of retinal disorders, ing relevant inpatient consultations They also participate extensively in including age-related macular degen throughout the Medical Center, and the continuing education and research eration, diabetic retinopathy, retinal assist in selected surgical procedures activities of the Orbital and Ophthal vascular disease, inflammatory reti of interest to neuro-ophthalmologists. mic Plastic Surgery Division. In addi nopathies, drug-related toxic retinop Attendance at the weekly neuro tion to publishing results of original athies, and retinal and macular de radiology teaching conferences is en research in peer-reviewed scientific generations and dystrophies. Fellows couraged. Time is allotted for scien- journals, fellows complete a formal are instructed in the proper use and tific reading and for research activities. thesis that partially satisfies the mem interpretation of noninvasive diagnos Participation in clinical research, such bership requirements of the Ameri tic tools, and training includes genetic as studies of eye movement disorders can Society of Ophthalmic Plastic and counseling and the proper use of mo and disturbances of visual pathways, Reconstructive Surgery. International lecular genetic diagnostics. Fellows is expected. research fellows also participate in will gain experience with a diverse the program annually. set of interventional skills, including a Fellowship in wide spectrum of retinal laser proce Ophthalmic Pathology Fellowship in Pediatric dures and periocular and intravitreal Under the direction of Dr. Ben J. Ophthalmology and Strabismus injection of various classes of drugs. Glasgow, this fellowship provides The division of Pediatric Ophthalmol Fellows divide their time among the preparation for an academic career in ogy and Strabismus offers one-year clinical practices of Drs. Gorin, David ophthalmic pathology. One-year, two- fellowships, under the directorship Sarraf, and Colin A. McCannel with year, and three-year training programs of Drs. Sherwin J. Isenberg and in the Division of Retinal Disorders are available depending on the back Joseph L. Demer. Clinical experience and Ophthalmic Genetics as well as ground of the applicant. Training en consists of supervised participation in the Retinal Diagnostics Unit and compasses many aspects of ophthal in the ophthalmic care of pediatric the Visual Physiology Laboratory di mic pathology. Fellows may choose patients seen at the Stein Eye Insti rected by Dr. Steven Nusinowitz at between a research or clinical-based tute, Harbor-UCLA Medical Center, UCLA. Dr. McCannel’s clinic provides curriculum. Clinical fellows gain ex and Olive View-UCLA Medical Cen exposure to surgical retinal decision- pertise in surgical pathology; autopsy ter. Specific activities include partic making and management issues. The pathology; cytology, including fine- ipation in University Ophthalmology fellows also provide care and teach needle aspiration; electron microsco Associates, the Nursery and Neona residents in retina subspecialty clinics py; immunohistochemistry; DNA in tal Intensive Care Units, Ophthalmic at two UCLA-affiliated hospitals. Fel situ hybridization; Southern blot anal Plastic and Reconstructive Surgery lows are strongly encouraged to en ysis; and polymerase chain reaction Service, and the Pediatric Retinal Ser gage in translational clinical research techniques for diagnostic work. The vice. Other activities in pediatric oph and/or clinical trials and descriptive fellowship programs are individualized thalmology include experience in the retrospective studies and develop an according to the credentials and capa private consultation suites and partic in-depth working knowledge of the bilities of each fellow. ipation in pediatric cases that are han current scientific literature of medical dled through other services. Fellows

Training Programs | Stein Eye Institute 93 may collaborate with vision scientists, Fellowship in and international meetings and pub including biochemists, physiologists, Vitreoretinal Diseases lish scientific papers. They gain a pathologists, and anatomists, on re and Surgery broad background in the vision sci search projects of mutual interest. Under the co-directorship of Drs. Allan ences by interacting with members E. Kreiger and Steven D. Schwartz, of adjacent laboratories and collab Fellowship in Uveitis and the Vitreoretinal Diseases and Surgery orating with faculty members other Inflammatory Eye Diseases Fellowship in the Department of Oph than their own preceptors. Postdoc This one-year fellowship, under the thalmology at the Stein Eye Institute toral research fellowships are offered direction of Dr. Gary N. Holland, is a two-year program designed to pro for one to three years. Each one is offers comprehensive training in the vide medical and surgical training and unique with research programs estab evaluation and management of uveitis clinical and vision science research lished according to mutual agreement and other inflammatory eye diseases. opportunities related to vitreoretinal between trainees and mentors. Re Fellows participate in the practices of disease. Major components of the search areas for postdoctoral fellows Drs. Holland and Ralph D. Levinson fellowship relate to diabetic retinopa include molecular biology, genetics, at the Stein Eye Institute and see thy, diseases of the macula and ret biophysics, biomechanics, cell biolo patients in the Uveitis Clinic at the ina, hereditary retinal degenerations, gy, eye development, and biochemis Harbor–UCLA Medical Center. They ocular trauma, ophthalmic oncology, try. Upon completion of their fellow assist with diagnostic evaluations, rhegmatogenous retinal disease, vit ships, trainees usually pursue careers emergency cases, management of im reoretinal surgery, pediatric retinal dis- in academia or industry. munomodulatory therapies, and peri ease, and diagnostic imaging. Clini operative care of patients undergoing cal training includes the prevention, International Fellowship and Exchange Program surgical procedures. Fellows also in diagnosis, and treatment of retinal, teract closely with members of other choroidal, vitreous, and related ocular To promote and encourage research clinical services who are involved in disease. Fellows participate in retinal and education interaction with oph the care of patients with inflammatory clinics and surgical procedures at the thalmology institutions throughout the eye diseases and related conditions Stein Eye Institute and four UCLA- world, the Stein Eye Institute offers (ie, Retina, Glaucoma, Cornea, and Pe affiliated hospitals. Clinical, laborato an International Ophthalmology Fel diatric Ophthalmology Services; Adult ry, or translational research is encour lowship and Exchange Program con and Pediatric Rheumatology Services; aged. Other activities include teaching sisting of one-year to two-year fellow Infectious Disease Service). of vitreoretinal diseases at the Stein ships under the supervision of specific Eye Institute and affiliated institutions Institute faculty. Candidates for these Research is an integral part of the and case presentations at teaching fellowships are nominated by presti fellowship program. Fellows may be sessions. The program also includes gious institutions outside the United come involved in patient-based or lab the participation of several interna States, and often hold academic po oratory-based projects, including spe tional fellows. sitions within their own countries. cial research programs in the Ocular Fellows participate in the clinical and Inflammatory Disease Center and col Fellowship in Vision Science research activities of ophthalmic sub laborations with investigators at other specialties according to their train- institutions. Fellows typically complete Predoctoral and postdoctoral fellow ing needs. and publish one or two original re ships in vision science are offered to search articles and frequently prepare individuals who have an interest in a book chapter or review on a subject specific research areas being pursued of interest. Fellows typically present by Institute faculty in highly special their research results at national aca ized laboratory environments. These demic meetings. Support is provided fellowships are supported either by for fellows to participate in the activ individual funds available to Institute ities of related subspecialty organiza professors or as part of a special pro tions, such as the annual meetings of gram offered under the auspices of the American Uveitis Society. a National Eye Institute Vision Sci ence Training Grant and directed by Dr. Gabriel H. Travis. Predoctoral fellows take a defined program of core courses and carry out eye-related research, obtaining doc torates in about six years. Fellows are required to present their research at informal and formal seminars, and are encouraged to participate in national

94 Stein Eye Institute | Training Programs APPENDICES Associate Clinical Professors Assistant Clinical Professors Volunteer and of Ophthalmology of Ophthalmology Kevin J. Belville, MD David H. Aizuss, MD Consulting Faculty W. Benton Boone, MD Malvin B. Anders, MD Harvey Brown, MD Richard K. Apt, MD Volunteer Faculty Andrew E. Choy, MD Reginald G. Ariyasu, MD, PhD in Ophthalmology Melissa W. Chun, OD Arthur A. Astorino, MD Clinical Professors Peter J. Cornell, MD John D. Bartlett, MD of Ophthalmology Uday Devgan, MD Mark A. Baskin, MD Chief of Ophthalmology Arthur Benjamin, MD Henry I. Baylis, MD Olive-View UCLA Medical Center Founding Chief of the Orbital and Ophthalmic Katherine L. Bergwerk, MD Plastic Surgery Division Paul B. Donzis, MD Betsy E. Blechman, MD David R. Fett, MD Cynthia A. Boxrud, MD Bruce B. Becker, MD Donald S. Fong, MD, MPH Amarpreet S. Brar, MD Michael S. Berlin, MD Donald I. Goldstein, MD Almira W. Cann, MD, PhD J. Bronwyn Bateman, MD Michael J. Groth, MD Arnett Carraby, MD William P. Chen, MD Thomas A. Hanscom, MD Vicki K. Chan, MD Leland M. Garrison, MD Andrew Henrick, MD Andrew M. Chang, MD John D. Hofbauer, MD Edwin P. Hill, MD Candice Chen, MD Kenneth J. Hoffer, MD Batool Jafri, MD Thomas B-H. Choi, MD C. Richard Hulquist, MD David F. Kamin, MD Milton W. Chu, MD Barry M. Kerman, MD Brian L. Lee, MD Robert A. Clark, MD Roger A. Kohn, MD Jonathan I. Macy, MD Charles A. Cooper, MD Howard R. Krauss, MD Joan E. McFarland, MD Yadavinder P. Dang, MD Benjamin C. Kwan, MD John F. Paschal, MD Jonathan M. Davidorf, MD Ezra Maguen, MD George M. Rajacich, MD John L. Davidson, MD Robert K. Maloney, MD Michael Reynard, MD Sanford S. Davidson, MD Samuel Masket, MD David S. Robbin, MD Louise Cooley Davis, MD Albert T. Milauskas, MD David E. Savar, MD Farid Eghbali, OD Anthony B. Nesburn, MD Timothy V. Scott, MD Troy R. Elander, MD Leon G. Partamian, MD Albert Sheffer, MD Naomi L. Ellenhorn, MD Yaron S. Rabinowitz, MD James D. Shuler, MD Calvin T. Eng, MD Teresa O. Rosales, MD Yossi Sidikaro, MD, PhD Robert E. Engstrom, MD Robert J. Schechter, MD Matthew Sloan, MD Doreen T. Fazio, MD Alan L. Shabo, MD Ronald J. Smith, MD Sanford G. Feldman, MD Norman Shorr, MD Alfred Solish, MD, MS Laura E. Fox, MD Roger W. Sorenson, MD Kenneth D. Steinsapir, MD Ronald P. Gallemore, MD William C. Stivelman, MD George H. Garcia, MD Hector L. Sulit, MD Kathryn M. Gardner, MD Kamal A. Zakka, MD Leslie C. Garland, MD W. James Gealy, Jr., MD Damien Goldberg, MD Richard Havunjian, MD Man M. Singh Hayreh, MD Matthew L. Hecht, MD Jonathan A. Hoenig, MD Jeffrey Hong, MD Catherine J. Hwang, MD, MPH Morton P. Israel, MD Steven J. Jacobson, MD Véronique H. Jotterand, MD J. David Karlin, MD David S. Katzin, MD Jerome R. Klein, MD Craig H. Kliger, MD Steven Leibowitz, MD Robert T. Lin, MD Joanne E. Low, MD Bryant J. Lum, MD Michael C. Lynch, MD M. Polly McKinstry, MD Ashish M. Mehta, MD David R. Milstein, MD

96 Stein Eye Institute | Appendices Assistant Clinical Professors of Ophthalmology continued Ronald L. Morton, MD Roger L. Novack, MD, PhD Alpa A.S. Patel, MD James H. Peace, MD Cheryl J. Powell, MD Firas Rahhal, MD Laurence N. Roer, MD Barry S. Seibel, MD Meryl Shapiro-Tuchin, MD Amelia Sheh, MD David M. Shultz, MD Eliot B. Siegel, MD Lance M. Siegel, MD John D. Slaney, MD Robert J. Smyth, MD Kenneth O. Sparks, MD Sadiqa Stelzner, MD Mehryar “Ray” Taban, MD, FACS Robert C. Tarter, MD Debra G. Tennen, MD Teddy Y. Tong, MD Henry E. Ullman, MD Sidney J. Weiss, MD Scott Whitcup, MD Clinical Instructors Consulting Members of the Jeffrey V. Winston, MD in Ophthalmology Stein Eye Institute David L. Wirta, MD Gavin G. Bahadur, MD Robert W. Baloh, MD Barry J. Wolstan, MD Eduardo Besser, MD Professor of Neurology and Surgery Wilson C. Wu, MD, PhD Maria Braun, MD (Head and Neck) Michael C. Yang, MD Neil D. Brourman, MD Ferdinand V. Coroniti, PhD Patrick C. Yeh, MD Stephen S. Bylsma, MD Professor, Department of Physics Richard H. Yook, MD Andrew Caster, MD and Astronomy Peter D. Zeegen, MD Joseph H. Chang, MD David Eisenberg, DPhil Hajir Dadgostar, MD Investigator, Howard Hughes Medical Institute Director, UCLA-DOE Institute Paul J. Dougherty, MD for Genomics and Proteomics Sean Dumars, MD Professor, Departments of Chemistry Daniel Ebroon, MD and Biochemistry, and Biological Chemistry Brad S. Elkins, MD Molecular Biology Institute Satvinder Gujral, MD Alan M. Fogelman, MD Lawrence M. Hopp, MD, MS Castera Professor and Executive Chair, Aarchan Joshi, MD Department of Medicine Anisha J. Judge, MD Alan D. Grinnell, PhD Rajesh Khanna, MD Professor of Physiology and Julie A. King, MD Physiological Science Mark H. Kramar, MD Director, Jerry Lewis Neuromuscular Research Center Daniel Krivoy, MD Director, Ahmanson Laboratory Laurie C. McCall, MD of Neurobiology David Paikal, MD Sherman M. Mellinkoff, MD Jayantkumar Patel, MD Professor Emeritus of Medicine Susan S. Ransome, MD Former Dean, UCLA School of Medicine Steven H. Rauchman, MD C. Kumar Patel, PhD Richard H. Roe, MD Professor, Department of Physics Aaron Savar, MD and Astronomy Kayar Shah, MD Leonard H. Rome, PhD Mark Silverberg, MD Senior Associate Dean for Research Abraham Soroudi, MD Professor of Biological Chemistry Sharon N. Spooner-Dailey, MD Peter C. Whybrow, MD Homayoun Tabandeh, MD Judson Braun Professor and Executive Chair, Dana P. Tannenbaum, MD Department of Psychiatry and William L. Trotter, MD Biobehavioral Sciences Mathew Wang, MD Director, Neuropsychiatric Institute Physician in Chief, Neuropsychiatric Hospital Peter H. Win, MD

Appendices | Stein Eye Institute 97 Clinical Fellows Vitreoretinal Diseases and Surgery Residents and Fellows Corneal and External Ocular Hamid Hosseini, MD, Iran Diseases and Refractive Surgery Maria Silvana Pellice, MD, Argentina Tatsuhiko Sato, MD, Japan Residents Ryan St. Clair, MD Po-Chen Tseng, MD, Hong Kong Third-Year Residents Rosalind Vo, MD 2011–2014 Glaucoma Postdoctoral Meena George, MD Renu Jivrajka, MD Research Fellows Anthony Joseph, MD Alena Reznik, MD Tina Ku, MD Navid Amini, PhD Medical Retina Doug Chung, PhD Robert Kule, MD and Ophthalmic Genetics Christine Lin, MD Jeremy Cook, PhD Saradha Iragavarapu, MD C. Nathaniel Roybal, MD, PhD (EyeSTAR) Matthias Elgeti, PhD Anitra Thomas, MD Orbital and Ophthalmic Julian Esteve-Rudd, PhD Dong Dawn Yang, MD Plastic Surgery Sheyla Gonzalez-Garrido, PhD Lei Gu, PhD Second-Year Residents Payam Morgan, MD Sonia Guha, PhD 2012–2015 Daniel Rootman, MD, MSc Mei Jiang, PhD Jamie K. Alexander, MD Pediatric Ophthalmology Justyna Kanska, PhD Melinda Y. Chang, MD and Strabismus Vanda Lopes, PhD Robert A. Lalane, MD Erica Oltra, MD Carlos Lopez, PhD Wenjing Liu, MD Anika Tandon, MD Hua Mei, PhD Aaron Nagiel, MD, PhD Uveitis and Inflammatory Johan Pahlberg, PhD Lina Rodriguez, MD Eye Disease Yu “Christie” Qin, PhD P. James Sanchez, MD Shanta Sarfare, PhD None First-Year Residents Kwang Sup “Andrew” Shin, PhD 2013–2016 Vitreoretinal Diseases and Surgery Kaushali Thakore-Shah, PhD Jenny Chen, MD David Cupp, MD Stefanie Volland, PhD Xiejing Chen, MD Sujit Itty, MD Hongxing Wang, PhD Diana Katsman, MD, PhD (EyeSTAR) Joshua Udoetuk, MD Yanjie Wang, PhD Wonchon Liu, MD Ryan Wong, MD Zhongyu Yang, PhD Grant Moore, MD Jang “Lawrence” Yoo, PhD Mitra Nejad, MD International Fellows Christian Sanfilippo, MD Predoctoral Cornea Research Mauricio E. Vargas, MD, PhD (EyeSTAR) Research Fellows None Guo Cheng Comprehensive Ophthalmology/ EyeSTAR Trainees Austin Dean Cataract Diana Katsman, MD, PhD Jun Deng Carlos Manuel Nicoli, MD, Argentina C. Nathaniel Roybal, MD, PhD Katherine Fehlhaber Victoria Tseng, MD Glaucoma Roni Hazim Mauricio E. Vargas, MD, PhD John Mark de Leon, MD, Philippines Yifeng Ke Eun Ah Kim, MD, South Korea Jun Isobe Ji Woong Lee, MD, South Korea Alan Le Sara Nowroozizadeh, MD, Iran Michael Lerch Francisco Otárola Mérino, MD, Chile Yingqian Peng Allison Sargoy Orbital and Ophthalmic Wei Wang Plastic Surgery Binbin Xie Aline Pimentel de Miranda, MD, Brazil Pediatric Ophthalmology Bhambi Gesite-de Leon, MD, Philippines Sun Young Shin, MD, South Korea Soh Youn Suh, MD, South Korea Pathology (Eye) None Uveitis Christian Böni, MD, Switzerland Visual Physiology None

98 Stein Eye Institute | Appendices Phacoemulsification Course Glaucoma Weekly Conference Educational Offerings October 19, 2013 This conference is designed to teach April 12, 2014 residents and fellows a basic understanding of the pathophysiology and Ophthalmology and Course Director: clinical care of glaucoma. Faculty, Vision Science Kevin M. Miller, MD fellows, and residents all participate Training Programs This course is a key component of the in case and subject presentations and discussions. The conferences are Ophthalmology Basic and residency-training program, as well as coordinated by Joseph Caprioli, MD. Clinical Science Course a resource for practicing ophthalmologists. Both classroom and laboratory Course Chairman: Neuro-Ophthalmology Conference Bartly J. Mondino, MD instruction are offered, covering in detail the procedural and anatomical This conference meets bimonthly and This course is a major segment of the components of modern sutureless includes full-time and volunteer clinical educational program for ophthalmol- phacoemulsification. faculty and visitors from the commu- ogy residents, as well as a review nity who discuss neuro-ophthalmology course for ophthalmologists. Sections Nineteenth Annual cases presented by fellows and resi are presented each year in a rotation Vision Science Conference dents. The coordinator for the year was Anthony C. Arnold, MD. designed to provide complete review October 24–26, 2013 of all sections in a three-year period. First-year residents participate in a At this annual event, sponsored jointly Oculoplastics Conference more intensive curriculum in order by the Stein Eye Institute and the This conference meets bimonthly and to obtain a comprehensive founda- National Eye Institute Vision Sci- includes full-time and volunteer clinical tion of ophthalmologic knowledge. ence Training Grant, pre- and post- faculty and visitors from the com- In 2013–2014, the following course doctoral fellows and faculty discuss munity who discuss oculoplastics and components were offered: a wide range of topics in vision orbital cases presented by fellows and science research. residents. The coordinator for the year Fundamentals and Principles was Robert Alan Goldberg, MD. of Ophthalmology Ophthalmology Joseph. L. Demer, MD, PhD Clinical Conferences Ophthalmic Pathology Conference August 21, 2013–September 25, 2013 Coordinators: Faculty and residents meet daily to review pathological findings from Glaucoma Anthony C. Arnold, MD Gary N. Holland, MD current ophthalmology cases. The Joseph Caprioli, MD coordinator for the year was Ben J. October 2, 2013–November 6, 2013 The Clinical Conferences are offered Glasgow, MD. External Disease/Cornea in conjunction with the regular weekly Anthony J. Aldave, MD Ophthalmology Basic and Clinical Pediatric Ophthalmology and November 27, 2013–January 22, 2014 Science Course. These conferences Strabismus Conference review patient care activities of the At monthly meetings rotating among Pathology UCLA Department of Ophthalmology, Harbor-UCLA Medical Center, Olive Ben J. Glasgow, MD present general topics in ophthalmic View-UCLA Medical Center, and the January 29, 2014–March 5, 2014 science, and promote discussion of Stein Eye Institute, difficult pediatric Orbit, Eyelids, and Lacrimal System relevant aspects of ophthalmic pathol- ophthalmology and strabismus cases Robert Alan Goldberg, MD ogy and pharmacy. are presented and discussed. These March 19, 2014–April 23, 2014 conferences were coordinated for the Study Groups year by Sherwin J. Isenberg, MD, at Lens/Cataract Focusing on specific topics in clinical Harbor-UCLA Medical Center, Federico Kevin M. Miller, MD ophthalmology, study groups meet Velez, MD, at Olive View-UCLA Medi- April 30, 2014–June 1, 2014 regularly under the leadership of fac- cal Center, and Joseph L. Demer, MD, ulty members who are acknowledged PhD, at the Stein Eye Institute. specialists in their respective fields. The study groups are an integral part Pediatric Rheumatology and of the residency and clinical fellow- Uveitis Conference ship training programs and serve as Members of the Uveitis Service an informal resource for practicing meet each week with members of ophthalmologists in the community. the Rheumatology Service from the Department of Pediatrics to discuss Retinal Imaging Conference patient-care issues and research top- Arranged by the clinical fellows in ics of mutual interest. The conference vitreoretinal studies, this conference is attended by faculty, clinical fellows convenes periodically to review cur- from the Departments of Ophthalmol- rent angiograms representing disease ogy and Pediatrics, and research staff. entities, unusual abnormalities, and The conference is coordinated by controversial interpretations of angio- Gary N. Holland, MD. graphic findings. Steven D. Schwartz, MD, and other members of the Retina Division, supervise the conference.

Appendices | Stein Eye Institute 99 Vision Science Seminar Series Master’s Orbital Surgery Stein Eye Institute Clinical Coordinators: Symposium and Research Seminar Sophie X. Deng, MD, PhD February 7–8, 2014 June 13, 2014 David S. Williams, PhD Coordinators: Coordinators: This seminar series, conducted Robert Alan Goldberg, MD Anthony C. Arnold, MD throughout the academic year, allows Jack Rootman, MD Robert Alan Goldberg, MD faculty within the Stein Eye Institute Norman Shorr, MD Bartly J. Mondino, MD to present their research to other Xian-Jie Yang, PhD The Orbital and Ophthalmic Plastic members of the Institute, thereby Surgery Division hosted a two-day Geared to physicians and basic sci- fostering the exchange of knowledge Master’s Symposium on Orbital Sur- entists, this seminar is an intensive and cooperation. The series frequently gery that included a laboratory session course in which UCLA and guest includes presentations by eminent visi- of cadaver dissection, didactic lectures, faculty present current concepts and tors to the UCLA campus. and case presentations. The course recent advances in ophthalmology. brought more than 60 participants The Jules Stein Lecture, the Bradley R. Continuing Education from across the world. Straatsma Lecture, and the Thomas H. Pettit Lecture, which commemorate Programs Comprehensive Ophthalmology each doctor’s contributions to ophthal- Aesthetic Eyelid and Review Course mic science at UCLA and throughout Facial Rejuvenation Course February 20–23, 2014 the United States, are held in conjunc- July 19–20, 2013 tion with this seminar and are among Course Directors: the academic highlights of the year. Coordinators: Sherwin Isenberg, MD Henry I. Baylis, MD John Irvine, MD 45th Jules Stein Lecturer Robert Alan Goldberg, MD Steven E. Feldon, MD, MBA The Stein Eye Institute and the Jonathan A. Hoenig, MD Director, Flaum Eye Institute Doheny Eye Institute sponsored Catherine J. Hwang, MD Professor and Chairman the Eighth Annual Comprehensive Norman Shorr, MD Department of Ophthalmology Ophthalmology Review Course. University of Rochester The Orbital and Oculoplastic Surgery Developed to serve ophthalmology- Rochester, NY Division held its annual Aesthetic training programs in Southern Cali- Eyelid and Facial Rejuvenation course fornia, the program concentrated on 12th Bradley R. Straatsma Lecturer at the Stein Eye Institute. The event the epidemiology, clinical presenta- Lois E. H. Smith, MD, PhD attracted ophthalmologists, dermatolo- tion, diagnosis, and management of Professor of Ophthalmology gists, and cosmetic surgeons from ophthalmological disease. Harvard Medical School around the world. The two-day event Clinician/Scientist combined surgical demonstrations, Pediatric Division Meeting Children’s Hospital a cadaver dissection, and didactic to Commemorate Dr. Leonard Apt Boston, MA lectures that informed participants April 1, 2014 12th Thomas H. Pettit Lecturer of the latest advances in the field of Amani A. Fawzi, MD Course Director: aesthetic and reconstructive surgery Associate Professor of Ophthalmology Joseph L. Demer, MD, PhD for the eyelids and face. Northwestern University The Stein Eye Institute Pediatric Chicago, IL Optometric Symposium Division organized and hosted this on Advances in Eye Care full-day meeting commemorating the January 26, 2014 late Leonard Apt, MD, a founding member of the Institute and the first Chairman: physician to become board certified Melissa Chun, OD in both pediatrics and ophthalmol- Optometrists from across California ogy. More than 40 invited speakers traveled to the Stein Eye Institute presented timely or controversial to attend the 16th Annual Stein Eye material on issues related to pediatric Institute and Marshall B. Ketchum ophthalmology. University joint Optometric Sympo- sium on Advances in Eye Care. The course included lectures given by featured speakers.

100 Stein Eye Institute | Appendices Research Contracts and Grants July 1, 2013–June 30, 2014

Vision Science Grants Total Award Anthony J. Aldave, MD Identification and Characterization of the Genetic Basis of PPCD National Eye Institute Duration: 12/1/12–11/30/17 $245,000

Dean Bok, PhD Identification and Cellular Localization of Gene Products that Affect Photoreceptor Survival in Inherited Retinal Degeneration Macula Vision Research Foundation Duration: 4/1/08–3/31/15 $50,000

Joseph Caprioli, MD Multi-Center Study for Normal Database of Optic Nerve Head, Retinal Nerve Fiber Layer, and Macula Parameters with the Heidelberg Spectralis OCT Heidelberg Engineering Duration: 9/25/13–9/24/15 $23,500

Anne L. Coleman, MD, PhD Immune Response Gene Polymorphisms and AMD: Examining HLA-KIR Epistasis California Pacific Medical Center Research Institute Duration: 7/1/13–6/30/14 $27,482 UCLA Mobile Eye Clinic Child Vision Program LA County Children and Families First (First 5 LA) Duration: 7/1/13–6/30/15 $649,500 Center For Community Outreach, Jules Stein Eye Institute at UCLA 2013–2014 The Nicholas Endowment Duration: 1/1/14–12/31/14 $100,000

Joseph L. Demer, MD, PhD Biomechanical Analysis in Strabismus Surgery National Eye Institute Duration: 5/1/14–4/30/16 $359,383 Training Mentors in Developing Countries Pediatric Ophthalmology Fellowship (Bambhi Uellyn Gesite-de Leon, MD, Fellow) Knights Templar Eye Foundation Inc. Duration: 7/1/13–6/30/14 $60,000

Sophie X. Deng, MD, PhD Ex Vivo Expansion of Human Limbal Stem Cells for Transplantation National Eye Institute Duration: 9/1/12–8/31/17 $237,500

Gary N. Holland, MD Multicenter Uveitis Steroid Treatment (MUST) Trial National Eye Institute Duration: 6/1/12–4/30/15 $23,000

Appendices | Stein Eye Institute 101 Joseph Horwitz, PhD Analysis of Lens Crystallins and Cataractous Mutants at High Hydrostatic Pressure National Eye Institute Duration: 4/1/14–3/31/19 $150,000

Wayne L. Hubbell, PhD Molecular Basis of Membrane Excitation National Eye Institute Duration: 5/1/10–4/30/15 $336,220 Core Grant for Vision Research at the Jules Stein Eye Institute National Eye Institute Duration: 3/1/10–2/28/15 $340,177 Molecular Basis of Selective P450 3A Function University of San Diego Duration: 3/1/11–2/28/14 $26,673

Bartly J. Mondino, MD RPB Unrestricted Grant Research to Prevent Blindness, Inc. Duration: 1/1/12–12/31/14 $110,000

Kouros Nouri-Mahdavi, MD Detection of Glaucoma Progression with Macular OCT Imaging National Eye Institute Duration: 7/1/12–6/30/17 $212,166

Stacy L. Pineles, MD Binocular Summation in Strabismus NIH/National Eye Institute Duration: 9/01/11–8/31/16 $200,237 Integrating Perceptual Learning Approaches into Effective Therapies for Low Vision University of California Riverside Duration: 9/1/13–7/31/15 $25,837

Natik I. Piri, PhD The Neuroprotective Effect of HSP72 Induction in Experimental Glaucoma National Eye Institute Duration: 9/30/09–8/31/14 $158,004

Roxana Radu, PhD Gene Therapy to Prevent Visual Loss in Macular Degenerations by Increasing Expression of Complement Negative-Regulatory Proteins in the RPE Macula Vision Research Foundation Duration: 10/1/13–9/30/16 $100,000

Alappakam P. Sampath, PhD Functional Characteristics of Rod Pathways in the Retina National Eye Institute Duration: 2/1/14–7/31/16 $169,125 Experimental and Clinical Investigations of Retinal Stimulation University of Southern California Duration: 10/1/13–2/28/15 $145,805

James Chee Hian Tan, MD, PhD Role of Trabecular Meshwork Contractility in Modulating Outflow Resistance National Eye Institute Duration: 6/16/14–8/31/14 $133,728

102 Stein Eye Institute | Appendices Gabriel H. Travis, MD The Role of Müller Cells in Visual Pigment Regeneration National Eye Institute Duration: 3/1/08–6/30/18 $325,650 Vision Science Training Grant to Researchers at the Jules Stein Eye Institute National Eye Institute Duration: 9/30/11–9/29/16 $224,437 Bruce Ford and Anne Smith Bundy Foundation Grant Bruce Ford and Anne Smith Bundy Foundation Duration: 8/16/11–8/15/14 $99,971

David S. Williams, PhD Doris and Jules Stein Research to Prevent Blindness Professorship Research to Prevent Blindness Duration: 1/1/08–12/31/14 $125,000 RPE Cell Biology of Myosin VIIa National Eye Institute Duration: 7/1/09–6/30/15 $225,720 The Photoreceptor Cilium National Eye Institute Duration: 5/1/13–4/30/18 $245,000 Degradative Processes in RPE-Photoreceptor Renewal University of Pennsylvania Duration: 2/1/14–1/31/15 $25,000 IPSC-JSEI Collaboration Project UCLA Broad Stem Cell Research Center Duration: 4/1/14–4/31/15 $52,000

Alejandra Young, PhD The Vision of Children Stem Cell Derived, OA1-Enriched, Microvesicles: Do They Rescue Ocular Albinism? Duration: 11/1/13–10/31/16 $174,720

Clinical Trials Lynn K. Gordon, MD, PhD A Phase I Open Label, Dose Escalation Trial of QPI-1007 Delivered by a Single Intrabitreal Injection to Patients with Optic Nerve Atrophy (Stratum I) Quark Pharmaceuticals, Inc. Duration: 3/17/10–3/16/15 $248,024

Gary N. Holland, MD Academic Research Organization for Research with Retinal Cells Derived from Stem Cells for Stargardt Macular Dystrophy Advanced Cell Technology Duration: 4/25/11–12/12/16 $428,740 Academic Research Organization for Research with Retinal Cells Derived from Stem Cells for Age-Related Macular Degeneration Advanced Cell Technology Duration: 5/31/11–12/12/16 $428,740 Academic Research Organization for Research with Retinal Cells Derived from Stem Cells for Geographic Atrophy Secondary to Myopic Macular Degeneration Advanced Cell Technology Duration: 3/31/14–3/31/16 $223,615

Appendices | Stein Eye Institute 103 A Randomized, Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Subjects with Non-Infectious Intermediate Posterior or Pan-Uveitis Currently Controlled with Systemic Treatment Xoma (US) LLC Duration: 1/8/13–11/25/14 $71,593 A Randomized Double-Masked, Placebo-Controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Active Non-Infectious Intermediate Posterior, or Pan-Uveitis Xoma (US) LLC Duration: 1/8/13–11/25/14 $101,943

Jean-Pierre Hubschman, MD A Phase 3, Randomized, Double-Masked, Controlled Trial to Establish the Safety and Efficacy of Intravitreous Administration of Fovista (Anti-PDGF-B Pegylated Aptamer)…ARMD Ophthotech Corporation Duration: 12/4/13–12/3/15 $130,650

Kevin M. Miller, MD Safety and Effectiveness of the Customflex Artificial Iris Prosthesis for the Treatment of Iris Defects Clinical Research Consultants, Inc. Duration: 6/12/14–6/14/16 $2,500

David Sarraf, MD Intravitreal AflibErcept Injection for the Treatment of Submacular Vascularized PigmEnt Epithelial DetachmeNt (EVEN Study) Southern California Desert Retina Consultants Duration: 2/7/13–12/31/14 $90,641

Steven D. Schwartz, MD Research with Retinal Cells Derived from Stem Cells for Stargardt Macular Dystrophy Advanced Cell Technology Duration: 3/23/11–3/11/15 $762,184 Research with Retinal Cells Derived from Stem Cells for Age-Related Macular Degeneration Advanced Cell Technology Duration: 4/5/11–3/11/15 $835,693 Research with Retinal Cells Derived from Stem Cells for Geographic Atrophy Secondary to Myopic Macular Degeneration Advanced Cell Technology Duration: 4/10/14–9/1/16 $750,317 Phase 1 Multicenter Open Label Safety and Tolerability Clinical Trial of Ciliary Neurotrophic Factor (CNTF) in Patients with Macular Telangiectasis Type 2 Neurotech Pharmaceuticals, Inc. Duration: 7/19/11–7/18/14 $28,401 A National History of Macular (Parafoveal) Telangiectasia Lowy Medical Research Institute Duration: 7/19/11–7/18/15 $185,695

104 Stein Eye Institute | Appendices Faculty, Doheny Eye Centers UCLA Vision Science Grants Alex A. Huang, MD, PhD Anterior Sclera Pathology in Glaucoma American Glaucoma Society Mentoring for Advancement of Physician-Scientists (MAPS) Award Duration: 3/14–3/15 $10,000

Deming Sun, MD Regulation by Gamma/Delta T Cells of Autoimmune Uveitis National Eye Institute Duration: 5/1/12–4/30/16 $287,142 Core Grant for Vision Research National Eye Institute Duration: 9/30/97–6/30/14 $125,443

James C. H. Tan, MD, PhD Role of Trabecular Meshwork Contractility in Modulating Outflow Resistance National Eye Institute 9/30/10–8/31/14 $247,933 Karl Kirchgessner Foundation Vision Research Grant The Karl Kirchgessner Foundation 10/17/09–Open $50,000

Clinical Trials Peter A. Quiros, MD NORDIC, Idiopathic Intracranial Hypertension Treatment Trial National Eye Institute 1/11–3/14 $25,000/year

SriniVas R. Sadda, MD Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order Amish University of Pennsylvania (Subaward on NEI Grant EY023164) 2/1/13–1/31/18 $62,866

Appendices | Stein Eye Institute 105 Eye Infections Factors Related to the Severity of Clinical Research Studies and Inflammations Ocular Toxoplasmosis Toxoplasmosis is a common parasitic A Comprehensive Analysis disease that can cause a vision- of Visual Function in Cornea and External Eye threatening infection of the retina. Patients Diagnosed with Individuals with and without ocular Analysis of the Corneal and Limbal Birdshot Chorioretinopathy Epithelial Changes in Limbal Stem toxoplasmosis are being evalu- The main goal in this study is to inves- Cell Deficiency using ated with a blood test to determine tigate the relationship between vision In Vivo Confocal Microscopy whether (1) people can have a genetic dysfunction (eg, symptoms, visual Investigators are working to estab- predisposition to severe disease when field changes, contrast sensitivity, and infected with the parasite, or (2) there lish a system for diagnosing limbal color vision changes) experienced stem cell deficiency at a cellular level is a particular strain of parasite that by patients diagnosed with birdshot causes more severe disease than by correlating the information from chorioretinopathy and the location impression cytology tests, confocal others. Investigators: Gary N. Holland, of defects in the retina as identi- MD, and Ralph D. Levinson, MD microscopy pictures, and medical fied by electrophysiological testing. records. Investigators: Sophie X. Deng, Investigators: Gary N. Holland, MD, MD, PhD, and Anthony J. Aldave, MD Longitudinal Studies of the Ocular Ralph D. Levinson, MD, and Steven Complications of AIDS (LSOCA) Nusinowitz, PhD Effect of Corneal Preservation LSOCA is a multicenter, National Eye Institute supported, epidemiological Time on Long-Term Graft Success A Comprehensive Analysis study designed to investigate the The purpose of this study is to evalu- of Visual Function in Patients nature of HIV-related eye diseases ate the effect of preservation time on Diagnosed with HIV since the introduction of potent anti- corneal transplants. It will compare the The main goal of this study is to deter- preservation time up to the FDA limit retroviral therapies. More than 2,000 mine the sequence of events that lead people with AIDS are being followed of 14 days and hopes to determine to visual disturbances in HIV-infected that longer preservation time does not nationwide. Investigator: Gary N. patients. Investigators will obtain Holland, MD adversely impact graft success and measures of visual function with a endothelial cell density. Investigators: series of established clinical electro- Anthony J. Aldave, MD, and Sophie X. Multicenter Uveitis Steroid physiological and psychophysical tests Treatment (MUST) Deng, MD, PhD commonly used to evaluate the func- Investigators are comparing two tion at different sites within the retina. currently available treatments for Genetic Basis of Posterior Results of this study may enable bet- uveitis. Systemic treatment utilizing Polymorphous Corneal Dystrophy ter understanding and measurements medications taken orally, by injec- Funded by the National Eye Institute, of how vision is affected in subjects tion, or by intravenous infusion is this study seeks to identify the gene(s) diagnosed with HIV. Investigators: being compared to treatment with an responsible for posterior polymor- Steven Nusinowitz, PhD, and Gary N. intraocular implant containing cortico- phous dystrophy, an inherited corneal Holland, MD endothelial disorder that may result in steroid. Investigators: Gary N. Holland, MD, Jean-Pierre Hubschman, MD, and irreversible corneal swelling and loss Corneal Endothelial Cell Changes Ralph D. Levinson, MD of vision. Investigators: Anthony J. in Children with Uveitis Aldave, MD, and Gary N. Holland, MD This is a prospective study to evaluate Natural Killer Cell Receptor Genes the cornea, specifically endothelial and AIDS-Related CMV Retinitis Identifying Novel Genes for Fuchs cells, in children with uveitis. Uveitis Institute faculty members are studying Corneal Endothelial Dystrophy is a general term meaning inflam- why some people with AIDS develop In this multicenter study, investi- mation inside the eye. Investigators CMV retinitis, an infection of the retina, gators are working to identify the will be comparing these changes for while others do not. This study aims gene(s) responsible for Fuchs corneal children with anterior uveitis who have to determine whether KIR genes, endothelial dystrophy, an inherited received a glaucoma drainage tube which control natural killer cell activi- disorder that may result in irreversible and those who have not. Investigators: ties and other immune functions, differ corneal swelling and loss of vision. Gary N. Holland, MD, Joseph Caprioli, between HIV-infected individuals who Investigators: Anthony J. Aldave, MD, MD, JoAnn A. Giaconi, MD, Simon develop CMV retinitis and those who Gary N. Holland, MD, and Bartly J. K. Law, MD, PharmD, and Ralph D. do not, despite similar risk factors. Mondino, MD Levinson, MD Investigators: Gary N. Holland, MD, Keratoprosthesis and Ralph D. Levinson, MD Implantation in Patients with Corneal Opacification This study aims to determine the success rate of keratoprosthesis (artificial corneal) transplantation for visual rehabilitation in patients with corneal opacification. Investigators: Anthony J. Aldave, MD, and Gary N. Holland, MD

106 Stein Eye Institute | Appendices Studies Evaluating a New Drug Glaucoma Drainage Devices Optic Nerve Appearance in in the Treatment of Patients and Filtering Surgery Age-Related Macular Degeneration with Uveitis with Antimetabolites In order to evaluate the relationship Uveitis is caused by inflammation of This study looks at the effect of two between macular degeneration and the middle layer of the eye. The pur- surgical procedures—glaucoma optic nerve change, digital imaging pose of this study is to find out more implant surgery and filtering surgery technology and photography are being about how the drug works, and if it is with antimetabolites—on the corneal used to assess the structural appear- effective for treating uveitis by limiting endothelium. It evaluates the possibil- ance of the optic nerve in patients one of the proteins that causes inflam- ity of surgical damage to the corneal with age-related macular degen- mation. Investigators: Gary N. Holland, endothelium, which may result in loss eration. Investigator: Simon K. Law, MD, and Ralph D. Levinson, MD of corneal clarity. Investigators: Anne MD, PharmD L. Coleman, MD, PhD, Joseph Caprioli, MD, JoAnn A. Giaconi, MD, and Role of Pattern Electroretinogram Glaucoma and Optic Nerve Simon K. Law, MD, PharmD (PERG) in Glaucoma This study is researching an electro Clinical Measurements of the Glaucoma Imaging Study Optic Nerve in Glaucoma physiological test called pattern This study is evaluating different imag- electroretinogram (PERG). The goal The goal of this study is to develop ing techniques and their use in improv- is to determine the role of PERG in novel structural measures of the optic ing open-angle glaucoma detection. estimating the risk of future glaucoma nerve and nerve fiber layer, which are Investigators: Kouros Nouri-Mahdavi, progression and the reversibility of sensitive and specific for early and MD, and Joseph Caprioli, MD glaucomatous damage after treatment. progressive glaucomatous optic nerve The latter could help clinicians better damage. Investigators: Joseph Caprioli, Glaucomatous Cupping and determine to what extent eye pres- MD, Anne L. Coleman, MD, PhD, and Visual Field Abnormalities in sure needs to be lowered to prevent Simon K. Law, MD, PharmD Chinese Young Adults disease progression. Investigators: Kouros Nouri-Mahdavi, MD, Joseph Earlier Intraocular Pressure The glaucoma-like syndrome is a condition where patients appear to have Caprioli, MD, Anne L. Coleman, MD, Control after Ahmed Glaucoma PhD, JoAnn A. Giaconi, MD, and Valve Implantation signs of glaucoma but are actually normal. This glaucoma-like syndrome Simon K. Law, MD, PharmD The purpose of this study is to evalu- is unusually common in young adult ate the occurrence rate of the high Chinese patients who normally would Vision-Related Quality of Life and pressure phase and the final pressure not be expected to show signs of Ocular Dominance outcomes between subjects treated eye disease. The purpose of the This study is designed to evaluate how with glaucoma medications prior to study is to determine the prevalence quality of life is impacted by glaucoma the onset of the high pressure phase and characteristics of the glaucoma- in relation to eye dominance. It aims and subjects who start glaucoma like syndrome in Chinese young to determine whether quality of life is medications at the onset of the high adults. Investigator: Simon K. Law, affected more by glaucoma if it primar- pressure phase. Investigators: Simon MD, PharmD ily affects the dominant eye. Investi- K. Law, MD, PharmD, Joseph Caprioli, gators: Simon K. Law, MD, PharmD, MD, Anne L. Coleman, MD, PhD, and Ocular Biometric Measurements in Joseph Caprioli, MD, Anne L. Coleman, JoAnn A. Giaconi, MD Angle-Closure Glaucoma MD, PhD, and JoAnn A. Giaconi, MD Effect of Yoga on Glaucoma The purpose of this study is to determine the potential contributing factors The purpose of this study is to in angle closure patients of different Lens and Cataract examine the practice of yoga and its ethnicities and to determine predic- ability to improve a patient’s vision by Morcher Iris Diaphragm tive factors for this type of glaucoma. relieving stress and reducing eye pres- After obtaining a compassionate use Investigators: Kouros Nouri-Mahdavi, sure. Investigator: Anne L. Coleman, Individual Device Exemption from the MD, Joseph Caprioli, MD, Anne L. MD, PhD U.S. Food and Drug Administration Coleman, MD, PhD, and Simon K. Law, to use the Morcher Iris Diaphragm MD, PharmD Eye Health Imaging Study implant in patients with partial or complete aniridia, the Institute is now The purpose of this study is to expand Ocular Hypertension evaluating its preliminary effective- the normative database for the Heidel Treatment Study ness. The implant is designed to limit berg Spectarlis OCT by collecting Since topical hypotensive medica- ophthalmic data from healthy eyes of the amount of light coming into the tions are safe and effective in delay- eye, similar to a natural iris, reducing people of Hispanic/Latino, Asian, and ing or preventing primary open angle African American descent. Investiga- symptoms of light sensitivity and glare. glaucoma, this study is examining Investigator: Kevin M. Miller, MD tors: Joseph Caprioli, MD, and Kouros whether other forms of treatment Nouri-Mahdavi, MD can be deferred with little or no pen- alty. Investigator: Anne L. Coleman, MD, PhD

Appendices | Stein Eye Institute 107 Ophtec Iris Reconstruction Lens A Study to Evaluate the Treatment Genetics of Age-Related The Institute is participating in a multi- of Subfoveal Pigment Epithelial Maculopathy (GARM II) center clinical investigation designed Detachment Associated with The purpose of this study is to identify to evaluate the safety and effective- Choroidal Neovascularization the hereditary and exposure risk fac- ness of the Ophtec Model 311 Iris The aim of this study is to see if the tors that lead to the development of Reconstruction Lens for the treatment treatment of pigment epithelial detach- age-related maculopathy (ARM) in of visual disturbances related to the ment is safe and effective with the a cohort with a family history of the absence of a portion of, or the entire, regular dose of intravitreal aflibercept disease. The study is intended for human iris. Investigator: Kevin M. injection. This study is being per- individuals (49 and older) who have at Miller, MD formed in collaboration with Southern least one parent with this condition, California Desert Retina Consultants. the spouses or partners of these indi- Post-Approval Study of ACRYSOF® Investigator: David Sarraf, MD viduals, and the parents themselves. IQ Toric High Cylinder Power Investigators: Michael B. Gorin, MD, Intraocular Lens Clinical Characterization, Genetic PhD, and Maria Carolina Ortube, MD This is a post-approval study of an Testing, and Visual Function in intraocular lens. The primary objective Patients with Stargardt Disease Heavy Metals in Surgically of this study is to evaluate an FDA- Investigators are doing a compre- Removed Human Ocular Tissue approved intraocular lens (Models hensive analysis of visual function in Faculty members are examining the SN6AT6-SN6AT9) for patients with patients diagnosed with Stargardt dis- concentration of heavy metals in corneal astigmatism. Investigators: ease, an early onset form of macular ocular tissue compared to blood con- Kevin M. Miller, MD, and D. Rex degeneration caused by a number of centrations. High volumes of specific Hamilton, MD mutations in the ABCR gene. They are heavy metals in the vitreous have performing molecular genetic testing been found to cause toxicity in the Safety and Effectiveness of the to confirm the Stargardt diagnosis retina. Information about the concen- Calhoun Vision Light Adjustable and better understand the diversity of trations of heavy metals in common Lens for Treating Postoperative the condition. Investigators: Michael vitreoretinal diseases could lead to Sphere and Cylinder B. Gorin, MD, PhD, Debora B. Farber, a new physiopathological approach. This is a prospective, randomized PhD, DPhhc, Steven Nusinowitz, PhD, Investigators: Jean-Pierre Hubschman, controlled multicenter clinical study to and Maria Carolina Ortube, MD MD, and Steven D. Schwartz, MD evaluate the safety and effectiveness of Light Adjustable Lens in subjects Dexamethasone Injections in Incidence of Late Macular with preoperative corneal astigmatism. the Treatment of Diabetic Degeneration in Older Women Investigators: Kevin M. Miller, MD, Macular Edema The goal of this research is to deter- Anthony J. Aldave, MD, and D. Rex Faculty members are participating in a mine the incidence of late age-related Hamilton, MD study to assess the safety and efficacy macular degeneration (AMD), the of 70 mg and 350 mg dexametha- rate of progression of AMD, and the sone posterior segment drug delivery association of specific risk factors Macula, Retina, and Vitreous systems in the treatment of patients such as diabetes mellitus and prior with diabetic macular edema. Investi- cataract surgery with late AMD and its Air, Perfluoropropane, and gators: Steven D. Schwartz, MD, Allan progression in older women. Investiga- Sulfur Hexafluoride Gas E. Kreiger, MD, and Tara A. McCannel, tor: Anne L. Coleman, MD, PhD Disappearance Variability MD, PhD after Vitrectomy Lucentis and Fovista Combination The purpose of this study is to evalu- Genetics of Age-Related Therapy for Wet AMD Compared ate different gases used in vitrectomy Maculopathy (GARM I) to Lucentis Only surgeries and to understand why In this multicenter study with the The purpose of this study is to there is variability in the time that University of Pittsburgh, investiga- evaluate the safety and efficacy of the different gases remain in the eye tors are evaluating the genetic and Fovista™ intravitreous administration after vitrectomy surgery. Investiga- environmental risks that contribute to when administered in combination tors: Jean-Pierre Hubschman, MD, and age-related maculopathy (ARM). The with Lucentis® compared to Lucentis Steven D. Schwartz, MD study is designed to identify genes monotherapy in subjects with sub- that alter susceptibility to ARM and foveal choroidal neovascularization A Safety and Tolerability determine the extent to which variants secondary to age-related macular Trial of CNTF in Patients with in these genes and other factors affect degeneration. Investigator: Jean-Pierre MacTel Type 2 one’s risk of developing the condition. Hubschman, MD This study is assessing the safety of Investigators: Michael B. Gorin, MD, the NT-501 implant in patients with PhD, and Maria Carolina Ortube, MD macular telangiectasia type 2. The device, an implant, is a small capsule of cells that is placed inside the eye. This allows a controlled, sustained release of CNTF directly to the retina. Investigators: Steven D. Schwartz, MD, Jean‑Pierre Hubschman, MD, and Allan E. Kreiger, MD

108 Stein Eye Institute | Appendices Microcystic Maculopathy P200CAF Autofluorescence Research with Retinal Cells Associated with Tamoxifen, Ultra-Widefield Scanning Laser Derived from Stem Cells for Paclitaxel, and Docetaxel Therapy Ophthalmoscope in Subjects Myopic Macular Degeneration Using Spectral-Domain Optical with Vitreoretinal Disease The aim of this study is to determine Coherence Tomography Imaging This study utilizes an ultra-widefield the safety and tolerability of subretinal We are evaluating chemotherapeutics scanning laser ophthalmoscope with transplantation of human embryonic used in the treatment of breast, lung, autofluorescence (SLO-AF) to take stem cell derived retinal pigmented stomach, and prostate cancer for eye pictures of the retina in a noninva- epithelial (MA09-hRPE) cells in complications. They are given via injec- sive way. Images acquired with the patients with geographic atrophy section and work by preventing micro SLO AF are compared with those ondary to myopic macular degenera- ‑ tubule function thus arresting mitotic from other currently available instru- tion. Investigators: Steven D. Schwartz, division. These drugs have been ments to evaluate the potentially MD, Jean-Pierre Hubschman, MD, and associated with microcystic maculopa- improved resolution for diagnosis of Allan E. Kreiger, MD thy. These findings have only been retinal eye diseases. Investigators: noted in sporadic case reports and this Steven D. Schwartz, MD, Jean-Pierre Research with Retinal Cells will be a prospective cohort study to Hubschman, MD, Allan E. Kreiger, MD, Derived from Stem Cells for define this complication. Investigator: and Tara A. McCannel, MD, PhD Stargardt Macular Dystrophy David Sarraf, MD This study is evaluating the safety of Pars Plana Vitrectomy surgical procedures used to implant Mobile Application to Enhance with and without ILM Peel MA09-hRPE cells, assessing the num- Diabetic Care This study is evaluating and comparing ber of cells to be transplanted in future This study is being conducted to possible differences in the vision, as studies, and evaluating measures determine whether use of an Internet well as the thickness and shape of the for determining the effectiveness of application to record and coordinate back of the eye, following pars plana future stem cell therapy for Stargardt diabetes management by the diabetic vitrectomy surgery with and without macular dystrophy. Investigators: patient, diabetes medical care team, internal limiting membrane peeling in Steven D. Schwartz, MD, Jean- and ophthalmology vision care team patients with complications of diabetic Pierre Hubschman, MD, and Allan E. results in improved control of diabetes retinopathy. Investigator: Jean-Pierre Kreiger, MD and decreased risk of eye complica- Hubschman, MD tions. Investigators: Irena Tsui, MD, Resolution of Vitreomacular and Bradley R. Straatsma, MD Rapid, Noninvasive, Regional Adhesion Associated with Functional Imaging of the Retina Neovascular Age-Related Natural History Study of In this study funded by the NIH, Macular Degeneration with Macular Telangiectasia Institute investigators are monitoring Intravitreal Microplasmin Investigators are collecting data about the responses of the pupil to light as a Faculty members are evaluating the macular telangiectasia with the goal method for detecting regional losses safety and efficacy of intravitreal injec- of acquiring more knowledge of and of function of the retina. The ultimate tion of microplasmin on age-related developing a treatment for this rare goal of this research is to develop a macular degeneration (AMD) with retinal disease. Investigators: Steven simple, noninvasive, rapid method focal vitreomacular adhesion (VMA). D. Schwartz, MD, Michael B. Gorin, for widespread screening of diabet- Previous research has shown that MD, PhD, Jean-Pierre Hubschman, ics in order to identify those who intravitreal microplasmin may offer MD, Allan E. Kreiger, MD, Tara A. may require medical attention and/or physicians a safe agent for resolu- McCannel, MD, PhD, and David therapy for diabetic retinopathy. Inves- tion of focal VMA in AMD patients Sarraf, MD tigators: Michael B. Gorin, MD, PhD, without surgery. Investigators: Steven and Maria Carolina Ortube, MD D. Schwartz, MD, and Jean-Pierre Ocular Hazards from Currently Hubschman, MD Available Light Curing Units Research with Retinal Cells The purpose of this study is to assess Derived from Stem Cells Understanding the Genetics of the potential of currently available for Dry Age-Related Inherited Eye Disorders curing lights to cause retinal damage Macular Degeneration (AMD) The Institute is participating in a study to dental personnel, to evaluate the This study is evaluating the safety of to search for the gene(s) respon- amount of exposure to curing lights surgical procedures used to implant sible for inherited disorders that are by dental personnel, and to assess MA09-hRPE cells, assessing the num- either specific to the eye or have current levels of retinal degenera- ber of cells to be transplanted in future eye findings as part of the medical tive changes in dental workers that studies, and evaluating measures condition. This study provides for the are possibly induced by curing lights. for determining the effectiveness clinical characterization of affected Investigators: Jean-Pierre Hubschman, of future stem cell therapy for AMD. individuals and at-risk family members, MD, and Steven D. Schwartz, MD Investigators: Steven D. Schwartz, in conjunction with molecular genetic MD, Jean-Pierre Hubschman, MD, and testing, to identify the causative genes Allan E. Kreiger, MD and mutations. Investigators: Anthony J. Aldave, MD, Michael B. Gorin, MD, PhD, and Maria Carolina Ortube, MD

Appendices | Stein Eye Institute 109 Vitamin Supplementation as Orbital and Ophthalmic Studies on Tissue in Treatment for Dry Age-Related Plastic Surgery Autoimmune Diseases Macular Degeneration This study aims to determine the A Research Study Evaluating This study explores the effects of cause of eye problems in Graves dis- a New Drug for the Treatment oral supplementation of lutein and ease and other autoimmune diseases. of Thyroid Eye Disease zeaxanthin and/or omega 3 long chain Examination is being done of material polyunsaturated fatty acids, called The purpose of this study is to obtain removed from orbits during surgical DHA and EPA, on the development of information on the safety and effec- therapy for Graves disease or other age-related macular degeneration and tiveness of an investigational drug to problems requiring surgery on the vision loss. Investigators: Steven D. treat thyroid eye disease (TED). People tissue surrounding the eyes, of thyroid Schwartz, MD, Michael B. Gorin, MD, with TED experience eye problems tissue removed during the course of PhD, Jean-Pierre Hubschman, MD, often due to an overactive thyroid surgical therapy, or of blood drawn for Allan E. Kreiger, MD, Tara A. McCannel, caused by Graves’ disease. Investiga- laboratory tests. Investigator: Robert MD, PhD, and David Sarraf, MD tor: Robert Alan Goldberg, MD Alan Goldberg, MD

Characteristics of the Brow–Eyelid Ultrasound Study of Ocular Melanoma Margin Relationship Eyelid Mobility Before and The purpose of this study is to deter- After Blepharoplasty and Molecular and Cytogenetic mine if changing the effect of gravity Injectable Fillers Studies of Ocular Melanoma has an effect on eyelid position. Inves- This study uses a high-resolution The goal of this research is to study tigator: Robert Alan Goldberg, MD ultrasound machine to capture real- ocular melanoma tumor tissue and time films of the tissues immediately to identify key molecular and genetic Hyaluronic Acid Gels for surrounding the eye. Patients in each features that could help predict those Upper Lid Retraction in of the following three arms are being patients who may be at high risk for Active State Thyroid Eye Disease studied: pre/post botulinum toxin metastasis. Investigators: Tara A. The purpose of this study is to injection, pre/post synthetic filler injec- McCannel, MD, PhD, Lynn K. Gordon, determine if hyaluronic acid gel (HAG) tion, and pre/post periocular cosmetic MD, PhD, and Bradley R. Straatsma, can be used reliably and reproduc- surgery, including fat repositioning or MD, JD ibly to correct upper eyelid retraction, fat transfer. Data gathered is being improve dry eye related symptoms, used to study the dispersion of filler Optical Coherence Tomography aesthetic appearance, and quality of injections, to gain more detailed of Regional Abnormalities life in active stage thyroid eye dis- and accurate insight into this cos- Associated with Choroidal ease (TED). The study also aims to metic field. Investigator: Robert Alan Nevus, Choroidal Melanoma, and determine the long-term outcome of Goldberg, MD Choroidal Melanoma Treated with TED and how long the effects of HAG Iodine-125 Brachytherapy can last. Investigator: Catherine J. Volumetric Analysis of In this study, optical coherence ther- Hwang, MD Orbital Images (CT and MRI apy (OCT) imaging is performed during Sequences) with Mimics regularly scheduled visits on patients Pro-Inflammatory Cytokines, Image Processing Software with choroidal nevus, choroidal Dry Eye, and Thyroid Eye Disease This study is evaluating the volumet- melanoma, and choroidal melanoma The purpose of this study is to ric changes of orbital tissues using treated with iodine-125 brachytherapy. determine whether there are specific a validated 3D image processing The purpose is threefold: to study the inflammatory proteins in tears of software. Orbital diseases such as structure and function of the retina patients with active stage thyroid eye thyroid eye disease, myositis, inflam- overlying the tumor and the macula, to disease (TED). If these inflammatory matory and neoplastic conditions are evaluate the effects of radiation on the proteins exist, the study aims to deter- characterized by significant soft tissue retina, and to compare OCT imaging to mine whether they can be used to changes. Their assessment with other imaging procedures. Investiga- predict dry eye symptomatology and if Mimics software is helpful in under- tors: Tara A. McCannel, MD, PhD, and they can be used to predict TED activ- standing the clinical course of these Bradley R. Straatsma, MD, JD ity. Investigators: Robert Alan Gold- diseases, as well as defining the etio- berg, MD, and Daniel Rootman, MD logic and pathogenetic mechanisms PET/CT Imaging for Early involved. Investigator: Robert Alan Detection of Ocular Melanoma Quality of Life Study in Goldberg, MD This research involves the use of Patients with Graves Disease combined positron emission tomog- This study is assessing the quality raphy (PET)/computed tomography of life in patients with Graves dis- (CT) scans in subjects with ocular ease orbitopathy before and after melanoma. It may ultimately provide medical treatment or medical pro- new knowledge that will be used to cedures. Investigator: Robert Alan develop better ways of monitoring for Goldberg, MD tumor spread and allow for early treatment if metastasis is found. Investiga- tors: Tara A. McCannel, MD, PhD, and Bradley R. Straatsma, MD, JD

110 Stein Eye Institute | Appendices Pediatrics and Strabismus Genetic and Anatomic Studies Prospective Study to Determine of Eye Movement Disorders the Proportion of Patients with A Randomized Clinical Trial of This collaborative National Eye Isolated Third, Fourth, and Sixth Observation Versus Occlusion Institute-funded study is conducting Nerve Palsies of Microvascular Therapy for Intermittent Exotropia magnetic resonance imaging of the Versus Nonmicrovascular Etiology Although occlusion treatment, or extraocular muscles. This procedure Currently, magnetic resonance imag- patching of the eye, is a widely used clarifies the phenotypes and mecha- ing scanning is only recommended treatment for intermittent exotropia nisms of congenital cranial dysinner- in atypical cases (ie, young age, no (IXT), there have been no randomized vation syndromes whose hereditary vascular risk factors). The purpose of clinical trials evaluating its effective- properties have been characterized this multicenter study is to determine ness. This study is being conducted to using modern molecular genetics. whether central nervous system assess the natural history of IXT and Patients with these syndromes have abnormalities are detected in patients to establish the effectiveness of patch- severe forms of strabismus. Investi who otherwise would not have ing in its treatment. Investigators: gator: Joseph L. Demer, MD, PhD neuroimaging. Investigator: Stacey L. Stacey L. Pineles, MD, and Federico G. Pineles, MD Velez, MD Optical Coherence Tomography in the Newborn Eye Sweep Visual Evoked Potential A Randomized Trial of The purpose of this study is to bet- for Use in Amblyopia and Pediatric Levadopa as Treatment for ter characterize the retina and optic Optic Nerve Disorders Residual Amblyopia (ATS17) nerve in newborns using spectral- Using a new technique, investiga- The objective of this study is to domain optical coherence tomography tors are measuring vision in preverbal compare the efficacy and safety of (SD-OCT). SD-OCT has been used children to diagnose and follow optic oral levodopa and patching versus for many years to help diagnose and nerve diseases. Currently, treatment oral placebo and patching in children treat adults with eye diseases, but decisions are based on clinical exami- 7 to <13 years for residual amblyopia. it has never been studied in new- nations that are insensitive and reveal Investigators: Stacy L. Pineles, MD, borns, where it could potentially help vision loss well after permanent dam- and Federico G. Velez, MD in the diagnoses of glaucoma, optic age has taken place. This technique nerve hypoplasia, foveal hypoplasia, allows more accurate examinations, Biomechanical Analysis in and colobomata, among many other leading to provision of treatments at Strabismus Surgery disorders. Investigator: Sherwin J. the first signs of vision loss, thereby This study aims to develop new Isenberg, MD decreasing the risk of permanent dam- diagnostic tests and computer models age. Investigators: Stacey L. Pineles, that will lead to improvements in Optic Nerve in Amblyopia MD, Joseph L. Demer, MD, PhD, strabismus surgery. Tests of binocular Amblyopia is a major cause of child- Sherwin Isenberg, MD, and Federico alignment and eye movements, as hood visual loss. This study uses high G. Velez, MD well as magnetic resonance imaging resolution, surface-coil magnetic reso- of the extraocular muscles, are being nance imaging to study optic nerve performed in the Institute’s Clinical size in amblyopia. It tests the theory and Basic Science Ocular Motility that the optic nerve is smaller than Laboratory before and after strabis- normal in amblyopia and that optic mus surgery. To date, this research nerve size may be a limiting factor has fundamentally contributed to the in restoration of vision by amblyopia knowledge of the functional anatomy treatment. Investigator: Joseph L. of the extraocular muscles and con- Demer, MD, PhD nective tissues, and allowed discovery of causes of common strabismus and Prevention of Visual Impairment development of new types of surger- in School-Age Children ies. Investigator: Joseph L. Demer, MD, PhD In this community-based participa- tory intervention to promote the use of eyeglasses in schools, first- and Contact Lens Study second-grade students with refractive The purpose of this study is to identify errors receive two pairs of eyeglasses, rates of complications and correla- with one pair staying at home and the tions to modality of wear, care system, other in the classroom. School nurses hygiene, or other factors associated collaborate with teachers in moni- with contact lens complications. Inves- toring the use of eyeglasses in the tigators: Vivian Phan, OD, Sharon Y. classroom, and parents receive eye Lee, OD, and Bartly J. Mondino, MD care education. Investigator: Anne L. Coleman, MD, PhD

Appendices | Stein Eye Institute 111 Zariwala MA, Gee HY, Kurkowiak M, Rahimy E, Wilson J, Tsao TC, Schwartz Al-Mutairi DA, Leigh MW, Hurd TW, S, Hubschman JP. Robot-assisted Publications of the Hjeij R, Dell SD, Chaki M, Dougherty intraocular surgery: development of Full-Time Faculty GW, Adan M, Spear PC, Esteve-Rudd the IRISS and feasibility studies in an J, Loges NT, Rosenfeld M, Diaz KA, animal model. Eye (Lond). 2013 Aug; Olbrich H, Wolf WE, Sheridan E, Batten Publications are ordered chronologically 27(8):972–8. July 1, 2013–June 30, 2014 TF, Halbritter J, Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns Repka MX, Yu F, Lum F, Coleman AL. Miller KM. July consultation #9. J Cata- KA, Ferkol TW, Sagel SD, Olivier KN, Strabismus among aged Medicare ben- ract Refract Surg. 2013 Jul;39(7):1128. Morgan LC, Werner C, Raidt J, Pen- eficiaries: impact of health status and nekamp P, Sun Z, Zhou W, Airik R, Nata- region. J AAPOS. 2013 Aug;17(4):391– Zutis K, Trucco E, , Hubschman JP rajan S, Allen SJ, Amirav I, Wieczorek 4. Epub 2013 Aug 6. Reed D, Shah S, van Hemert J. D, Landwehr K, Nielsen K, Schwerk N, Towards automatic detection of abnor- Nagiel A, Freund KB, Spaide RF, Munch Sertic J, Köhler G, Washburn J, Levy S, mal retinal capillaries in ultra-widefield- IC, Larsen M, Sarraf D. Mechanism of Fan S, Koerner-Rettberg C, Amselem S, of-view retinal angiographic exams. retinal pigment epithelium tear forma- Williams DS, Mitchell BJ, Drummond Conf Proc IEEE Eng Med Biol Soc. tion following intravitreal anti-vascular IA, Otto EA, Omran H, Knowles MR, 2013;2013:7372–5. endothelial growth factor therapy Hildebrandt F. ZMYND10 is mutated in revealed by spectral-domain optical Miller KM, Amesbury EC. F1000Prime primary ciliary dyskinesia and interacts coherence tomography. Am J Ophthal- Recommendation of Hayashi K et with LRRC6. Am J Hum Genet. 2013 mol. 2013 Nov;156(5):981– al., Corneal endothelial damage after Aug 8;93(2):336–45. Epub 2013 Jul 25. 988.e2. Epub 2013 Aug 20. cataract surgery in eyes with pseudo Ford N, Shubber Z, Saranchuk P, Pathai exfoliation syndrome, J Cataract Refract Pineles SL, Velez G, Velez FG. Asym- S, Durier N, O’Brien DP, Mills EJ, Pas- Surg 2013; 39:881–7. In F1000Prime, metric inferior oblique anterior trans- cual F, Hoen E, Holland GN, Heiden D. 03 Jul 2013. position for incomitant asymmetric Burden of HIV-related cytomegalovirus dissociated vertical deviation. Grae- Majumder A, Pahlberg J, Boyd KK, retinitis in resource-limited settings: a fes Arch Clin Exp Ophthalmol. 2013 Kerov V, Kolandaivelu S, Ramamurthy V, systematic review. Clin Infect Dis. 2013 Nov;251(11):2639–42. Epub 2013 Sampath AP, Artemyev NO. Trans- Nov;57(9):1351–61. Epub 2013 Jul 29. Aug 24. ducin translocation contributes to rod Review. survival and enhances synaptic trans- Arnold AC, Costa RM, Dumitrascu OM. 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112 Stein Eye Institute | Appendices Kempen JH, Sugar EA, Jaffe GJ, Zhan X, Larson DE, Wang C, Koboldt Chang SH, Papageorgiou KI, Ang M, Acharya NR, Dunn JP, Elner SG, DC, Sergeev YV, Fulton RS, Fulton King AJ, Goldberg RA. High-resolution Lightman SL, Thorne JE, Vitale AT, LL, Fronick CC, Branham KE, Bragg- ultrasound as an effective and practical Altaweel MM; Multicenter Uveitis Ste- Gresham J, Jun G, Hu Y, Kang HM, Liu tool to analyze eyebrow profile expan- roid Treatment (MUST) Trial Research D, Othman M, Brooks M, Ratnapriya R, sion in thyroid-associated periorbitopa- Group (Hubschman JP). Fluorescein Boleda A, Grassmann F, von Strachwitz thy. Ophthal Plast Reconstr Surg. 2013 angiography versus optical coherence C, Olson LM, Buitendijk GH, Hofman Sep-Oct;29(5):382–5. tomography for diagnosis of uveitic A, van Duijn CM, Cipriani V, Moore AT, macular edema. Ophthalmology. 2013 Shahid H, Jiang Y, Conley YP, Morgan Rahimy E, Sarraf D. Paraneoplastic Sep;120(9):1852–9. 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Identifica- Mrejen S, Sarraf D, Mukkamala risk associated with radiographic tion of a rare coding variant in comple- SK, Freund KB. Multimodal imaging imaging-reply. JAMA Ophthalmol. 2013 ment 3 associated with age-related of pigment epithelial detachment: Sep;131(9):1249. macular degeneration. Nat Genet. 2013 a guide to evaluation. Retina. 2013 Nov;45(11):1375–9. Epub 2013 Sep 15. Oct;33(9):1735–62. Review. Song X, Seo J, Baameur F, Vishnivetskiy SA, Chen Q, Kook S, Kim M, Brooks EK, Gasymov OK, Abduragimov AR, Sarraf D, Rahimy E, Fawzi AA, Sohn Altenbach C, Hong Y, Hanson SM, Pala- Glasgow BJ. A simple model-free E, Barbazetto I, Zacks DN, Mittra RA, zzo MC, Chen J, Hubbell WL, Gurevich method for direct assessment of Klancnik JM Jr, Mrejen S, Goldberg NR, EV, Gurevich VV. Rapid degeneration fluorescent ligand binding by linear Beardsley R, Sorenson JA, Freund KB. of rod photoreceptors expressing self- spectral summation. 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Appendices | Stein Eye Institute 113 Wells JA 4th, Aldave AJ, Tsui I. Surgi- Zhong M1, Kawaguchi R, Ter-Stepanian Ashraf S, Gee HY, Woerner S, Xie LX, cal technique: hand-over-hand retrieval M, Kassai M, Sun H. Vitamin A trans- Vega-Warner V, Lovric S, Fang H, Song of a posteriorly dislocated DSAEK graft port and the transmembrane pore in the X, Cattran DC, Avila-Casado C, Paterson in an eye with an iris reconstruction cell-surface receptor for plasma retinol AD, Nitschké P, Bole-Feysot C, Cochat lens. Ophthalmic Surg Lasers Imaging binding protein. PLoS One. 2013 Nov P, Esteve-Rudd J, Haberberger B, Allen Retina. 2013 Nov 1;44(6):569–71. Epub 1;8(11):e73838. SJ, Zhou W, Airik R, Otto EA, Barua M, 2013 Oct 24. Al-Hamed MH, Kari JA, Evans J, Bier- Rhee KD, Nusinowitz S, Chao K, zynska A, Saleem MA, Böckenhauer D, Gasymov OK, Abduragimov AR, Yu F, Bok D, Yang XJ. CNTF-mediated Kleta R, El Desoky S, Hacihamdioglu Glasgow BJ. 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J Cataract Refract Surg. 2013 Epub 2013 Nov 7. corneal dystrophy as a corneal ectatic Nov;39(11):1753–63. disorder following confirmation of Reingruber J, Pahlberg J, Woodruff ML, associated significant corneal steep- Kim MJ, Yu F, Aldave AJ. Microbial ker- Sampath AP, Fain GL, Holcman D. ening. JAMA Ophthalmol. 2013 Dec; atitis after Boston type I keratoprosthe- Detection of single photons by toad and 131(12):1583–90. sis implantation: incidence, organisms, mouse rods. Proc Natl Acad Sci risk factors, and outcomes. Ophthalmol- U S A. 2013 Nov 26;110(48):19378–83. Bakhtiari P, Agarwal DR, Fernandez ogy. 2013 Nov;120(11):2209–16. Epub 2013 Nov 8. AA, Milman T, Glasgow B, Starr CE, Aldave AJ. Corneal keloid: report of Miller KM, Yu F, Date RC. Reply: Rabinowitz R, Velez FG, Pineles SL. natural history and outcome of surgi- To PMID 23489917. J Cataract Refract Risk factors influencing the outcome cal management in two cases. Cornea. 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Appendices | Stein Eye Institute 115 Qin Y, Fu M, Takahashi M, Iwanami A, Kodjebacheva GD, Maliski S, Coleman Nowroozizadeh S, Cirineo N, Amini N, Kuga D, Rao RG, Sudhakar D, Huang T, AL. Use of Eyeglasses Among Children Knipping S, Chang T, Chou T, Kiyohara M, Torres K, Dillard C, Inagaki in Elementary School: Perceptions, Caprioli J, Nouri-Mahdavi K. Influ- A, Kasahara N, Goodglick L, Braun J, Behaviors, and Interventions Discussed ence of correction of ocular magnifica- Mischel PS, Gordon LK, Wadehra M. by Parents, School Nurses, and Teach- tion on spectral-domain OCT retinal Epithelial Membrane Protein-2 (EMP2) ers During Focus Groups. Am J Health nerve fiber layer measurement variabil- Activates Src and is a Novel Therapeu- Promot. 2014 Apr 9. ity and performance. Invest Ophthalmol tic Target for GBM. J Biol Chem. 2014 Vis Sci. 2014 Apr 29;55(6):3439–46. Mar 18. De Salvo G, Keane PA, Tufail A, Sarraf D. Diagnostic and Therapeutic Chal- Chaudhuri Z, Demer JL. Surgical Ashki N, Chan AM, Qin Y, Wang W, lenges. Retina. 2014 Apr 11. outcomes following rectus muscle pli- Kiyohara M, Lin L, Braun J, Wadehra M, cation: a potentially reversible, vessel- Gordon LK. Peroxynitrite upregulates Kim BJ, Ying GS, Huang J, Levy NE, sparing alternative to resection. JAMA angiogenic factors VEGF-A, BFGF, and Maguire MG; CATT Research Group Ophthalmol. 2014 May;132(5):579–85. (McCannel CA). Sporadic visual acuity HIF-1α in human corneal limbal epithelial cells. Invest Ophthalmol Vis Sci. loss in the Comparison of Age-Related Hagstrom SA, Ying GS, Pauer GJ, 2014 Mar 19;55(3):1637–46. Macular Degeneration Treatments Sturgill-Short GM, Huang J, Maguire Trials (CATT). Am J Ophthalmol. 2014 MG, Martin DF. Comparison of Age- Crouse JA, Lopes VS, Sanagustin JT, Jul;158(1):128–135.e10. Epub 2014 Apr Related Macular Degeneration Treat- Keady BT, Williams DS, Pazour GJ. Dis- 13. ments Trials (CATT) Research Group tinct functions for IFT140 and IFT20 in (McCannel CA). VEGFA and VEGFR2 opsin transport. Cytoskeleton (Hobo- Goldberg RA, Rootman DB, Nassiri gene polymorphisms and response to ken). 2014 May;71(5):302–10. Epub N, Samimi DB, Shadpour JM. Orbital anti-vascular endothelial growth factor 2014 Mar 25. Tumors Excision without Bony Mar- therapy: comparison of age-related ginotomy under Local and General macular degeneration treatments tri- Goh AS, Kohn JC, Rootman DB, Lin Anesthesia. J Ophthalmol. 2014; als (CATT). JAMA Ophthalmol. 2014 JL, Goldberg RA. Hyaluronic Acid gel 2014:424852. Epub 2014 Apr 14. May;132(5):521–7. distribution pattern in periocular area with high-resolution ultrasound imaging. Tsui I, Drexler A, Stanton AL, Kageyama Rahimy E, Sarraf D. Paracentral acute Aesthet Surg J. 2014 May 1;34(4):510– J, Ngo E, Straatsma BR. Pilot Study middle maculopathy spectral-domain 5. Epub 2014 Mar 25. Using Mobile Health to Coordinate the optical coherence tomography feature Diabetic Patient, Diabetologist, and of deep capillary ischemia. Curr Opin Calderón JL, Shaheen M, Hays RD, Ophthalmologist. Ophthalmol. 2014 May;25(3):207–12. Fleming ES, Norris KC, Baker RS. J Diabetes Sci Technol. 2014 Apr 14. Review. Improving Diabetes Health Literacy by Animation. Diabetes Educ. 2014 Mar Hendler K, Pineles SL, Demer JL, Yang Song BJ, Caprioli J. New directions 27;40(3):361–372. D, Velez FG. Adjustable augmented in the treatment of normal tension rectus muscle transposition surgery glaucoma. Indian J Ophthalmol. 2014 Tsui I, Ebani E, Rosenberg JB, Angert with or without ciliary vessel sparing May;62(5):529–37. RM, Lin J, Mian U. Trends in retinopa- for abduction deficiencies. Strabismus. thy of prematurity over a 5-year period 2014 Jun;22(2):74–80. Epub 2014 Apr Pang CE, Shah VP, Sarraf D, Freund KB. in a racially diverse population. Ophthal- 17. Ultra-Widefield Imaging With Auto- mic Surg Lasers Imaging Retina. 2014 fluorescence and Indocyanine Green Mar-Apr;45(2):138–42. Kwong JM, Vo N, Quan A, Nam M, Angiography in Central Serous Chorio- Kyung H, Yu F, Piri N, Caprioli J. The retinopathy. Am J Ophthalmol. 2014 Mei H, Nakatsu MN, Baclagon ER, dark phase intraocular pressure May 1. Deng SX. Frizzled 7 maintains the elevation and retinal ganglion cell undifferentiated state of human limbal degeneration in a rat model of experi- Rahimy E, Sarraf D, Dollin ML, Pitcher stem/progenitor cells. Stem Cells. 2014 mental glaucoma. Exp Eye Res. 2013 JD, Ho AC. Paracentral Acute Middle Apr;32(4):938–45. Jul;112:21–8. Epub 2013 Apr 18. Maculopathy in Nonischemic Central Retinal Vein Occlusion. Am J Ophthal- Shah SU, Koenig MJ, Dacquay Y, Leon BG, Demer JL. Sclerosing cavern- mol. 2014 May 1. Mozayan A, Hubschman JP. Assess- ous hemangioma of the cavernous ment of the risk of needlestick injuries sinus mimicking congenital fibrosis Kimbrel EA1, Kouris NA, Yavanian associated with intravitreal injections. of the extraocular muscles. J AAPOS. GJ, Chu J, Qin Y, Chan A, Singh RP, Retina. 2014 Apr;34(4):781–4. 2014 Jun;18(3):299–301. Epub 2014 McCurdy D, Gordon L, Levinson RD, Apr 18. Lanza R. Mesenchymal stem cell Lee JM, Caprioli J, Nouri-Mahdavi K, population derived from human pluri Afifi AA, Morales E, Ramanathan M, Yu Kim MJ, Frausto RF, Rosenwasser GO, potent stem cells displays potent F, Coleman AL. Baseline prognostic Bui T, Le DJ, Stone EM, Aldave AJ. immunomodulatory and therapeutic factors predict rapid visual field deterio- Posterior amorphous corneal dystrophy properties. Stem Cells Dev. 2014 Jul ration in glaucoma. Invest Ophthalmol is associated with a deletion of small 15;23(14):1611–24. Epub 2014 May 2. Vis Sci. 2014 Apr 7;55(4):2228–36. leucine-rich proteoglycans on chromo- some 12. PLoS One. 2014 Kaylor JJ, Cook JD, Makshanoff J, McCannel TA, McCannel CA. Iodine Apr 23;9(4). Bischoff N, Yong J, Travis GH. 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116 Stein Eye Institute | Appendices Gordon LK, Goldstein DA. Gender and Piri N, Kwong JM, Caprioli J. Crystal- Ratnapriya R, Zhan X, Fariss RN, uveitis in patients with multiple sclero- lins in retinal ganglion cell survival and Branham KE, Zipprer D, Chakarova CF, sis. J Ophthalmol. 2014;2014:565262. regeneration. Mol Neurobiol. 2013 Sergeev YV, Campos MM, Othman M, Epub 2014 May 7. Review. Dec;48(3):819–28. Epub 2013 May 25. Friedman JS, Maminishkis A, Waseem Review. NH, Brooks M, Rajasimha HK, Edwards Gee HY, Ashraf S, Wan X, Vega-Warner AO, Lotery A, Klein BE, Truitt BJ, Li B, V, Esteve-Rudd J, Lovric S, Fang H, Bitrian E, Song BJ, Caprioli J. Bleb Schaumberg DA, Morgan DJ, Morrison Hurd TW, Sadowski CE, Allen SJ, Otto Revision for Resolution of Hypotony MA, Souied E, Tsironi EE, Grassmann F, EA, Korkmaz E, Washburn J, Levy S, Maculopathy Following Primary Tra Fishman GA, Silvestri G, Scholl HP, Kim Williams DS, Bakkaloglu SA, Zolotnits- beculectomy. Am J Ophthalmol. 2014 IK, Ramke J, Tuo J, Merriam JE, Mer- kaya A, Ozaltin F, Zhou W, Hildebrandt May 27. riam JC, Park KH, Olson LM, Farrer LA, F. Mutations in EMP2 cause childhood- Johnson MP, Peachey NS, Lathrop M, onset nephrotic syndrome. Am J Hum Liu W, Rootman DB, Berry JL, Hwang CJ, Goldberg RA. Methicillin- Baron RV, Igo RP Jr, Klein R, Hagstrom Genet. 2014 Jun 5;94(6):884–90. Epub SA, Kamatani Y, Martin TM, Jiang Y, 2014 May 8. Resistant Staphylococcus aureus Dac- ryoadenitis. JAMA Ophthalmol. 2014 Conley Y, Sahel JA, Zack DJ, Chan CC, Goldberg RA. Future of cosmetic May 29. Pericak-Vance MA, Jacobson SG, Gorin surgery. Facial Plast Surg. 2014 Apr; MB, Klein ML, Allikmets R, Iyengar 30(2):101–2. Epub 2014 May 8. Kirschen D, Isenberg SJ. The effective- SK, Weber BH, Haines JL, Léveillard T, ness of an autorefractor with eye- Deangelis MM, Stambolian D, Weeks Idiga J, Rootman DB, Nagiel A, Gold- tracking capability in pediatric patients. DE, Bhattacharya SS, Chew EY, Heck- berg RA. Isolated Zygomycetes Endop J AAPOS. 2014 Jun;18(3):217–21. enlively JR, Abecasis GR, Swaroop A. thalmitis: A Case Report. Ophthal Plast Rare and common variants in extracel- Reconstr Surg. 2014 May 14. Pihlblad MS, Demer JL. Hypertropia in unilateral isolated abducens palsy. lular matrix gene Fibrillin 2 (FBN2) are Kohn JC, Rootman DB, Liu W, Goh AS, J AAPOS. 2014 Jun;18(3):235–40. associated with macular degeneration. Hwang CJ, Goldberg RA. Hyaluronic Hum Mol Genet. 2014 Jun 4. Acid Gel Injection for Upper Eyelid Zhong M, Kawaguchi R, Kassai M, Sun H. Apo-RBP, holo-RBP, and Rootman DB, Kim MJ, Aldave AJ, Retraction in Thyroid Eye Disease: Douglas R, Hwang C, Goldberg R. Functional and Dynamic High- insulin resistance. Mol Cell Biol. 2014 Jun;34(11):2105–6. Ocular Surface, Fornix, and Eyelid Resolution Ultrasound Evaluation. Oph- Rehabilitation in Boston Type I Kerato thal Plast Reconstr Surg. 2014 May 14. Zhong M, Kawaguchi R, Kassai M, Sun prosthesis Patients With Mucous Mem- Lerch MT, Yang Z, Brooks EK, Hubbell H. How free retinol behaves differently brane Disease. Ophthal Plast Reconstr WL. Mapping protein conformational from rbp-bound retinol in RBP receptor- Surg. 2014 Jun 6. heterogeneity under pressure with mediated vitamin A uptake. Mol Cell Biol. 2014 Jun;34(11):2108–10. Anastasopoulos E, Coleman AL, site-directed spin labeling and double Wilson MR, Sinsheimer JS, Yu F, Katafi- electron-electron resonance. Proc Natl Joseph A, Rahimy E, Sarraf D. Bilateral giotis S, Founti P, Salonikiou A, Pappas Acad Sci U S A. 2014 Apr 1;111(13): diffuse uveal melanocytic proliferation T, Koskosas A, Katopodi T, Lambropou- E1201–10. Epub 2014 Mar 18. with multiple iris cysts. JAMA Ophthal- los A, Topouzis F. Association of LOXL1 Law SK, Kornmann HL, Nilforushan N, mol. 2014 Jun 1;132(6):756–60. Polymorphisms With Pseudoexfoliation, Glaucoma, Intraocular Pressure, and Moghimi S, Caprioli J. Evaluation of Mitry D, Bhogal M, Patel AK, Lee the “IS” Rule to Differentiate Glauco- Systemic Diseases in a Greek Popula- BS, Chai SM, Price MO, Price FW Jr, tion. The Thessaloniki Eye Study. Invest matous Eyes From Normal. J Glaucoma. Jun AS, Aldave AJ, Mehta JS, Busin 2014 May 19. Ophthalmol Vis Sci. 2014 Jun 10;55(7): M, Allan BD. Descemet stripping 4238–43. Demer JL, Clark RA. Magnetic Reso- automated endothelial keratoplasty nance Imaging of Differential Compart- after failed penetrating keratoplasty: Yen M, Ausayakhun S, Chen J, mental Function of Horizontal Rectus survival, rejection risk, and visual out- Ausayakhun S, Jirawison C, Heiden D, Extraocular Muscles During Conjugate come. JAMA Ophthalmol. 2014 Jun 1; Holland GN, Margolis TP, Keenan JD. and Converged Ocular Adduction. 132(6):742–9. Telemedicine Diagnosis of Cytomegalo J Neurophysiol. 2014 May 21. virus Retinitis by Nonophthalmologists. JAMA Ophthalmol. 2014 Jun 19. 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Appendices | Stein Eye Institute 117 Giving Opportunities

The Stein Eye Institute is dedicated to the preservation of sight and the prevention of blindness. Today, UCLA’s vision scientists are extending the boundaries of current knowledge and approaching the goal for a lifetime of good vision for everyone, due in large part to a strong tradition of philanthropy from private sources.

Contributions from individuals, foundations, and corporations, help underwrite exemplary patient-care programs, innovative scientific advances, key community engagement, and the highest-quality training and education. The Institute offers a variety of giving options to those who wish to contribute to this tradition of excellence.

How to Support the Stein Eye Institute

Direct Gifts Real Estate Endowments Direct gifts of cash, securities, or other When you give a gift of your home or A gift of an endowment demonstrates property provide the Institute with real property to the Institute, you may a long-term commitment to the much-needed financial assistance. Out- claim an income-tax charitable deduc- Institute, since the fund is maintained right gifts have an immediate impact on tion based on the full market value of in perpetuity. A portion of the annual faculty research, education, and patient the gift, avoid capital gains taxes, and investment income is used to sup- care programs because they are used eliminate certain costs associated with port clinical, educational, and scientific to support a variety of current needs. the transfer of real property. Gifts of real initiatives and the remaining invest- estate can also provide income to you. ment yield is returned to principal, thus, Gift Pledges over the years, the fund can grow and A pledge is a formal statement of inten- Bequests provide continuous support. tion to make a gift to the Institute. It In writing a will or living trust, donors An endowment serves as an endur- may be followed by an immediate gift, can specify that they would like their ing legacy as it can bear the donor’s or may simply confirm your intention to estate or various assets to benefit the name, or can honor a loved one. These make a gift in the future. Many donors Institute, thereby building a legacy at funds can be made payable for up to choose to complete their gift pledge by the Stein Eye Institute. five years. Giving opportunities exist making regular payments over a five- for endowed chairs, endowed fellow- year period. This method often allows Charitable Gift Annuity ships, and endowed funds for research, donors to give more generously than Donors can transfer money, securities, education, and patient care. they may have originally considered. or real estate in trust to the Institute Whenever possible, full payment of and receive income for themselves Qualified Retirement Plans pledges is encouraged within five years or a loved one for life. Donors may Naming The UCLA Foundation as a of the original commitment. receive immediate tax benefits, and beneficiary of your qualified retirement the Institute ultimately receives the plan (IRA, KEOGH, 401(k) or 403(b)) Securities trust property. may be particularly advantageous. A gift of long-term appreciated market- Doing so may result in more assets able securities helps you save taxes Tribute Gifts being passed on to your heirs than if twice. Such a gift will provide an Contributions may be made in memory, you make a bequest from other funds income-tax charitable deduction and honor, or celebration of a loved one, or in your estate. capital gains tax savings. to commemorate a special occasion. Donations can be used for unrestricted Matching Gifts program support or be directed to any Many corporations have demonstrated area of the Institute. their support by matching or multiplying their employees’ gifts to the Institute up to a set amount. Before making a gift, you may want to ask whether your Your Gift Can Make a Difference employer participates in a matching However you choose to support the Institute, you will be embarking on a partnership gift program. Certain restrictions apply with one of the world’s preeminent eye research centers. Such an investment will to matching gifts. Please consult your greatly expand our understanding of the causes of eye diseases, expose alternative company’s personnel office. treatment options, and ultimately prevent blindness. For information on how to incorporate the Stein Eye Institute into your estate and retirement planning, or to make a gift of any kind, please contact: Stein Eye Institute Development Office To make a gift, you may also 100 Stein Plaza, Room 1-124 download a remittance form University of California, Los Angeles from our website by visiting: Los Angeles, California 90095-7000 jsei.org/about/about_giving.htm. Phone: (310) 206-6035 Fax: (310) 794-1665 [email protected] 118 Stein Eye Institute | Appendices Stein Eye Institute Annual Report

July 1, 2013–June 30, 2014

Director Bartly J. Mondino, MD

Faculty Advisor Debora B. Farber, PhD, DPhhc

Managing Editor Tina-Marie Gauthier c/o Stein Eye Institute 100 Stein Plaza, UCLA Los Angeles, California 90095–7000 Email: [email protected]

Editors Teresa Closson Ellen Haupt Rosalie Licht Peter J. López Debbie Sato M. Gail Summers

Guest Writer Dan Gordon

Photography Reed Hutchinson J. Charles Martin ASUCLA Photography

Design Robin Weisz/Graphic Design

Printing Colornet Press

Send questions, comments, and updates to: [email protected].

To view the Annual Report online, visit: jsei.org/annual_report.htm.

For more information about the Institute, see: www.jsei.org.

Annual Report 2013–2014

Annual Report 2013–2014Annual Report

TRANSFORMING EYE CARE

LOS ANGELES AND BEYOND

The Stein Eye Institute is a proud affiliate of the Doheny Eye Institute.

David Geffen School of Medicine at UCLA University of California, Los Angeles