Frequently Asked Questions Regarding COVID-19 V8.Pdf
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Postviral Bronchial Hyperreactivity Syndrome: Recognizing Asthma's
• Postviral bronchial hyperreactivity syndrome: Recognizing asthmas great mimic DAVID OSTRANSKY, DO FRANCIS X. BLAIS, DO Although there are no prospec- (Key words: Viral infections, asthma, tive studies regarding the frequency of respiratory tract infections, postviral postviral bronchial hyperreactivity syn- bronchial hyperreactivity syndrome) drome, it is a common complication of upper and lower respiratory tract viral Viral respiratory tract infections frequently infections. The respiratory symptoms cause wheezing and other asthmalike symp- closely resemble those of asthma, but they toms. Several investigators have demonstrated are present for only 3 weeks to 3 months pertinent features of this abbreviated form of following the acute infection phase. Defin- asthma, including early response phase, late ing the mechanisms of this syndrome may response phase, and bronchial hyperreac- provide insight into the pathogenesis of tivity. 1-5 Understanding the mechanisms by asthma. Postviral bronchial hyperreac- which viral respiratory tract infections precipi- tivity syndrome is frequently misdiag- tate the airway abnormalities of asthma may nosed and inappropriately managed be- be a potential key to the pathogenesis of cause many physicians are unfamiliar asthma, although whether viral respiratory with this illness. Because of its character- tract infections truly cause asthma is un- istic history, diagnosis is straightforward proved.6 when the physician knows what to look The symptom complex following viral up- for, and response to therapy is excellent. per or lower respiratory tract infections (or This report presents a case history fol- both) has not been formally identified. It is fre- lowed by a review of the proposed mecha- quently misdiagnosed by physicians who then nisms of bronchial hyperreactivity follow- institute inappropriate diagnostic studies and ing viral respiratory infections. -
COVID-19 Pneumonia: the Great Radiological Mimicker
Duzgun et al. Insights Imaging (2020) 11:118 https://doi.org/10.1186/s13244-020-00933-z Insights into Imaging EDUCATIONAL REVIEW Open Access COVID-19 pneumonia: the great radiological mimicker Selin Ardali Duzgun* , Gamze Durhan, Figen Basaran Demirkazik, Meltem Gulsun Akpinar and Orhan Macit Ariyurek Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread worldwide since December 2019. Although the reference diagnostic test is a real-time reverse transcription-polymerase chain reaction (RT-PCR), chest-computed tomography (CT) has been frequently used in diagnosis because of the low sensitivity rates of RT-PCR. CT fndings of COVID-19 are well described in the literature and include predominantly peripheral, bilateral ground-glass opacities (GGOs), combination of GGOs with consolida- tions, and/or septal thickening creating a “crazy-paving” pattern. Longitudinal changes of typical CT fndings and less reported fndings (air bronchograms, CT halo sign, and reverse halo sign) may mimic a wide range of lung patholo- gies radiologically. Moreover, accompanying and underlying lung abnormalities may interfere with the CT fndings of COVID-19 pneumonia. The diseases that COVID-19 pneumonia may mimic can be broadly classifed as infectious or non-infectious diseases (pulmonary edema, hemorrhage, neoplasms, organizing pneumonia, pulmonary alveolar proteinosis, sarcoidosis, pulmonary infarction, interstitial lung diseases, and aspiration pneumonia). We summarize the imaging fndings of COVID-19 and the aforementioned lung pathologies that COVID-19 pneumonia may mimic. We also discuss the features that may aid in the diferential diagnosis, as the disease continues to spread and will be one of our main diferential diagnoses some time more. -
Pediatric Ambulatory Community Acquired Pneumonia (CAP)
ANMC Pediatric (≥3mo) Ambulatory Community Acquired Pneumonia (CAP) Treatment Guideline Criteria for Respiratory Distress Criteria For Outpatient Management Testing/Imaging for Outpatient Management Tachypnea, in breaths/min: Mild CAP: no signs of respiratory distress Vital Signs: Standard VS and Pulse Oximetry Age 0-2mo: >60 Able to tolerate PO Labs: No routine labs indicated Age 2-12mo: >50 No concerns for pathogen with increased virulence Influenza PCR during influenza season Age 1-5yo: >40 (ex. CA-MRSA) Blood cultures if not fully immunized OR fails to Age >5yo: >20 Family able to carefully observe child at home, comply improve/worsens after initiation of antibiotics Dyspnea with therapy plan, and attend follow up appointments Urinary antigen detection testing is not Retractions recommended in children; false-positive tests are common. Grunting If patient does not meet outpatient management criteria Radiography: No routine CXR indicated Nasal flaring refer to inpatient pneumonia guideline for initial workup Apnea and testing. AP and lateral CXR if fails initial antibiotic therapy Altered mental status AP and lateral CXR 4-6 weeks after diagnosis if Pulse oximetry <90% on room air recurrent pneumonia involving the same lobe Treatment Selection Suspected Viral Pneumonia Most Common Pathogens: Influenza A & B, Adenovirus, Respiratory Syncytial Virus, Parainfluenza No antimicrobial therapy is necessary. Most common in <5yo If influenza positive, see influenza guidelines for treatment algorithm. Suspected Bacterial -
Pathology of Allergic Bronchopulmonary Aspergillosis
[Frontiers in Bioscience 8, e110-114, January 1, 2003] PATHOLOGY OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS Anne Chetty Department of Pediatrics, Floating Hospital for Children, New England Medical Center, Boston, MA TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Immunopathogenesis 4. Pathologic Findings 4.1. Plastic bronchitis 4.2. Allergic fungal sinusitis 4.3. ABPA in cystic fibrosis 5. Acknowledgement 6. References 1. ABSTRACT Allergic bronchopulmonary aspergillosis (ABPA) individuals with episodic obstructive lung diseases such as occurs in patients with asthma and cystic fibrosis when asthma and cystic fibrosis that produce thick, tenacious Aspergillus fumigatus spores are inhaled and grow in sputum. bronchial mucus as hyphae. Chronic colonization of Aspergillus fumigatus and host’s genetically determined Decomposing organic matter serves as a substrate immunological response lead to ABPA. In most cases, for the growth of Aspergillus species. Because biologic lung biopsy is not necessary because the diagnosis is made heating produces temperatures as high as 65° to 70° C, on clinical, serologic, and roentgenographic findings. Some Aspergillus spores will not be recovered in the latter stages patients who have had lung biopsies or partial resections of composting. Aspergillus species have been recovered for atelectasis or infiltrates will have histologic diagnoses. from potting soil, mulches, decaying vegetation, and A number of different histologic diagnoses can be found sewage treatment facilities, as well as in outdoor air and even in the same patient. In the early stages the bronchial Aspergillus spores grow in excreta from birds (1) wall is infiltrated with mononuclear cells and eosinophils. Mucoid impaction and eosinophilic pneumonia are seen Allergic fungal pulmonary disease is manifested subsequently. -
Percutaneous Endoscopic Gastrostomy Versus Nasogastric Tube Feeding: Oropharyngeal Dysphagia Increases Risk for Pneumonia Requiring Hospital Admission
nutrients Article Percutaneous Endoscopic Gastrostomy versus Nasogastric Tube Feeding: Oropharyngeal Dysphagia Increases Risk for Pneumonia Requiring Hospital Admission Wei-Kuo Chang 1,*, Hsin-Hung Huang 1, Hsuan-Hwai Lin 1 and Chen-Liang Tsai 2 1 Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; [email protected] (H.-H.H.); [email protected] (H.-H.L.) 2 Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan; [email protected] * Correspondence: [email protected]; Tel.: +886-2-23657137; Fax: +886-2-87927138 Received: 3 November 2019; Accepted: 4 December 2019; Published: 5 December 2019 Abstract: Background: Aspiration pneumonia is the most common cause of death in patients with percutaneous endoscopic gastrostomy (PEG) and nasogastric tube (NGT) feeding. This study aimed to compare PEG versus NGT feeding regarding the risk of pneumonia, according to the severity of pooling secretions in the pharyngolaryngeal region. Methods: Patients were stratified by endoscopic observation of the pooling secretions in the pharyngolaryngeal region: control group (<25% pooling secretions filling the pyriform sinus), pharyngeal group (25–100% pooling secretions filling the pyriform sinus), and laryngeal group (pooling secretions entering the laryngeal vestibule). Demographic data, swallowing level scale score, and pneumonia requiring hospital admission were recorded. Results: Patients with NGT (n = 97) had a significantly higher incidence of pneumonia (episodes/person-years) than those patients with PEG (n = 130) in the pharyngeal group (3.6 1.0 ± vs. 2.3 2.1, P < 0.001) and the laryngeal group (3.8 0.5 vs. -
Community-Acquired Pneumonia in Children KIMBERLY STUCKEY-SCHROCK, MD, Memphis, Tennessee BURTON L
Community-Acquired Pneumonia in Children KIMBERLY STUCKEY-SCHROCK, MD, Memphis, Tennessee BURTON L. HAYES, MD, and CHRISTA M. GEORGE, PharmD University of Tennessee Health Science Center, Memphis, Tennessee Community-acquired pneumonia is a potentially serious infection in children and often results in hospitalization. The diagnosis can be based on the history and physical examination results in children with fever plus respiratory signs and symptoms. Chest radiography and rapid viral testing may be helpful when the diagnosis is unclear. The most likely etiology depends on the age of the child. Viral and Streptococcus pneumoniae infections are most common in preschool-aged children, whereas Mycoplasma pneumoniae is common in older children. The decision to treat with antibiotics is challenging, especially with the increasing prevalence of viral and bacterial coinfections. Preschool-aged children with uncomplicated bacterial pneumonia should be treated with amoxicillin. Macrolides are first-line agents in older children. Immunization with the 13-valent pneumococcal conjugate vaccine is important in reducing the severity of childhood pneumococcal infections. (Am Fam Physician. 2012;86(7):661-667. Copyright © 2012 American Academy of Family Physicians.) ommunity-acquired pneumonia infection accounts for 30 to 50 percent of CAP (CAP) is a significant cause of infections in children.7 respiratory morbidity and mor- Streptococcus pneumoniae is the most com- tality in children, especially in mon bacterial cause of CAP. The widespread C developing countries.1 Worldwide, CAP is the use of pneumococcal immunization has leading cause of death in children younger reduced the incidence of invasive disease.8 than five years.2 Factors that increase the Children with underlying conditions and incidence and severity of pneumonia in chil- those who attend child care are at higher risk dren include prematurity, malnutrition, low of invasive pneumococcal disease. -
Aspergillosis Complicating Severe Coronavirus Disease Kieren A
SYNOPSIS Aspergillosis Complicating Severe Coronavirus Disease Kieren A. Marr, Andrew Platt, Jeffrey A. Tornheim, Sean X. Zhang, Kausik Datta, Celia Cardozo, Carolina Garcia-Vidal describing epidemiology and significance of aspergil- Aspergillosis complicating severe influenza infection losis occurring after severe viral infections, especially has been increasingly detected worldwide. Recently, coronavirus disease–associated pulmonary aspergil- influenza and coronavirus disease (COVID-19). losis (CAPA) has been detected through rapid reports, Aspergillosis associated with severe influenza primarily from centers in Europe. We provide a case virus infection (influenza-associated aspergillosis, series of CAPA, adding 20 cases to the literature, with IAA) was reported in 1951, when Abbott et al. de- review of pathophysiology, diagnosis, and outcomes. scribed fatal infection in a woman with cavitary in- The syndromes of pulmonary aspergillosis complicating vasive pulmonary aspergillosis noted on autopsy (2). severe viral infections are distinct from classic invasive Scattered reports appeared in thereafter; Adalja et al. aspergillosis, which is recognized most frequently in summarized 27 cases in the literature during 1952– persons with neutropenia and in other immunocompro- 2011, which reported predominance after influenza mised persons. Combined with severe viral infection, A infection, associated lymphopenia, and occurring aspergillosis comprises a constellation of airway-inva- in persons of a broad age range (14–89 years), but sive and angio-invasive disease and results in risks as- sociated with poor airway fungus clearance and killing, with little underlying lung disease (3). There were including virus- or inflammation-associated epithelial increased numbers of cases reported during and af- damage, systemic immunosuppression, and underlying ter the 2009 influenza A(H1N1) pandemic (3–10). -
IDSA/ATS Consensus Guidelines on The
SUPPLEMENT ARTICLE Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults Lionel A. Mandell,1,a Richard G. Wunderink,2,a Antonio Anzueto,3,4 John G. Bartlett,7 G. Douglas Campbell,8 Nathan C. Dean,9,10 Scott F. Dowell,11 Thomas M. File, Jr.12,13 Daniel M. Musher,5,6 Michael S. Niederman,14,15 Antonio Torres,16 and Cynthia G. Whitney11 1McMaster University Medical School, Hamilton, Ontario, Canada; 2Northwestern University Feinberg School of Medicine, Chicago, Illinois; 3University of Texas Health Science Center and 4South Texas Veterans Health Care System, San Antonio, and 5Michael E. DeBakey Veterans Affairs Medical Center and 6Baylor College of Medicine, Houston, Texas; 7Johns Hopkins University School of Medicine, Baltimore, Maryland; 8Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi School of Medicine, Jackson; 9Division of Pulmonary and Critical Care Medicine, LDS Hospital, and 10University of Utah, Salt Lake City, Utah; 11Centers for Disease Control and Prevention, Atlanta, Georgia; 12Northeastern Ohio Universities College of Medicine, Rootstown, and 13Summa Health System, Akron, Ohio; 14State University of New York at Stony Brook, Stony Brook, and 15Department of Medicine, Winthrop University Hospital, Mineola, New York; and 16Cap de Servei de Pneumologia i Alle`rgia Respirato`ria, Institut Clı´nic del To`rax, Hospital Clı´nic de Barcelona, Facultat de Medicina, Universitat de Barcelona, Institut d’Investigacions Biome`diques August Pi i Sunyer, CIBER CB06/06/0028, Barcelona, Spain. EXECUTIVE SUMMARY priate starting point for consultation by specialists. Substantial overlap exists among the patients whom Improving the care of adult patients with community- these guidelines address and those discussed in the re- acquired pneumonia (CAP) has been the focus of many cently published guidelines for health care–associated different organizations, and several have developed pneumonia (HCAP). -
Not Every Wheeze Is Asthmatic: an Aspiration Pneumonia Case Report
Arch Clin Med Case Rep 2021; 5 (3): 368-372 DOI: 10.26502/acmcr.96550368 Case Report Not Every Wheeze is Asthmatic: An Aspiration Pneumonia Case Report Gabriel Melo Alexandre Silva1, Herbert Iago Feitosa Fonseca1, Pablo André Brito de Souza1, Ana Cássia Silva Oliveira1, Luciana Lopes Albuquerque da Nobrega2* 1Medical School, Federal University of Roraima, Boa Vista, RR, Brazil 2Medial Doctor, Pediatric Pulmonologist, Professor in Pediatrics, Federal University of Roraima, Boa Vista, RR, Brazil *Corresponding Author: Luciana Lopes Albuquerque da Nobrega, Medical School of Roraima, Federal University of Roraima, Av. Capitão Ene Garcez, 2413, Boa Vista, RR, 69310-000, Brazil Received: 01 April 2021; Accepted: 16 April 2021; Published: 03 May 2021 Abstract Introduction: Wheezing in infants is an extremely common complaint, being markedly frequent in emergency services. Nonetheless, such a complaint is part of a wide spectrum of pathologies thus, demanding deeper investigation over the differential diagnosis must be addressed in an appropriate manner, in order to implement the necessary therapy as early as possible, and excessive intervention avoided, as much as possible Therefore, this case- report seeks to serve as a reminder of the importance of keeping a high suspicion on aspiration pneumonia even in previously healthy patients. The Case: HPDJ, male, date of birth (Dec, 30th of 2019), then 10 months and 10 days old, enters the medical emergency service of the pediatric hospital on November, 10th of 2020, with a report of flu-like symptoms that persisted for 10 days. The possibilities of bronchiolitis, pneumonia and SARS-COV 2 are questioned given the pandemic context, therefore being approached with salbutamol and prednisolone, chest x-ray and complementary exams. -
Radiologically Suspected Organizing Pneumonia in a Patient Recovering from COVID-19: a Case Report
Infect Chemother. 2021 Mar;53(1):e8 https://doi.org/10.3947/ic.2021.0013 pISSN 2093-2340·eISSN 2092-6448 Case Report Radiologically Suspected Organizing Pneumonia in a Patient Recovering from COVID-19: A Case Report Hyeonji Seo 1, Jiwon Jung 1, Min Jae Kim 1, Se Jin Jang 2, and Sung-Han Kim 1 1Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Received: Jan 28, 2021 ABSTRACT Accepted: Feb 10, 2021 Corresponding Author: We report a case of coronavirus disease 2019 (COVID-19)-associated radiologically suspected Sung-Han Kim, MD organizing pneumonia with repeated negative Severe acute respiratory syndrome coronavirus Department of Infectious Diseases, Asan 2 (SARS-CoV-2) polymerase chain reaction (PCR) results from nasopharyngeal swab Medical Center, University of Ulsan College of and sputum samples, but positive result from bronchoalveolar lavage fluid. Performing Medicine, 88, Olympic-ro, 43-gil, Songpa-gu, SARS-CoV-2 RT-PCR in upper respiratory tract samples only could fail to detect COVID-19- Seoul 05505, Korea. Tel: +82-2-3010-3305 associated pneumonia, and SARS-CoV-2 could be an etiology of radiologically suspected Fax: +82-2-3010-6970 organizing pneumonia. E-mail: [email protected] Keywords: COVID-19; SARS-CoV-2; Organizing pneumonia; Bronchoalveolar lavage; Copyright © 2021 by The Korean Society Polymerase chain reaction of Infectious Diseases, Korean Society for Antimicrobial -
Wandering Consolidation 685 Postgrad Med J: First Published As 10.1136/Pgmj.71.841.685 on 1 November 1995
Wandering consolidation 685 Postgrad Med J: first published as 10.1136/pgmj.71.841.685 on 1 November 1995. Downloaded from Wandering consolidation Michael AR Keane, David M Hansell, Charles RK Hind A 63-year-old man who had previously been fit and well, developed an acute illness with headaches and fever. His chest X-ray is shown in figure 1. Other investigations revealed an elevated lactate dehydrogenase and gamma glutamyl transferase and transient microscopic haematuria for which no cause was found. Following antibiotic treatment, his symptoms settled. Over the next six weeks he complained of increasing breathlessness but had no other symptoms. His family doctor found signs ofleft lower lobe consolidation and treated him with antibiotics, but there was no symptomatic improvement and he was referred to hospital. It was noted that he had travelled to Canada, Fiji, Australia, and Singapore a year previously. On examination he appeared unwell and he had signs of left-sided consolidation. He was in atrial fibrillation and was normotensive. Routine blood tests were normal other than an erythrocyte sedimentation rate of 75 mm/h. His repeat chest X-ray is shown in figure 2. Figure 1 Initial chest X-ray Figure 2 Chest X-ray six weeks later Royal Brompton http://pmj.bmj.com/ Hospital, London SW3 6NP, UK MAR Keane DM Hansell Royal Liverpool University Hospital, Liverpool L7 8XP, UK on September 29, 2021 by guest. Protected copyright. CRK Hind Questions Correspondence to Dr DM 1 What is the most likely diagnosis? Hansell Accepted 3 May 1995 2 Suggest three alternative diagnoses. -
Cryptogenic Organizing Pneumonia
462 Cryptogenic Organizing Pneumonia Vincent Cottin, M.D., Ph.D. 1 Jean-François Cordier, M.D. 1 1 Hospices Civils de Lyon, Louis Pradel Hospital, National Reference Address for correspondence and reprint requests Vincent Cottin, Centre for Rare Pulmonary Diseases, Competence Centre for M.D., Ph.D., Hôpital Louis Pradel, 28 avenue Doyen Lépine, F-69677 Pulmonary Hypertension, Department of Respiratory Medicine, Lyon Cedex, France (e-mail: [email protected]). University Claude Bernard Lyon I, University of Lyon, Lyon, France Semin Respir Crit Care Med 2012;33:462–475. Abstract Organizing pneumonia (OP) is a pathological pattern defined by the characteristic presence of buds of granulation tissue within the lumen of distal pulmonary airspaces consisting of fibroblasts and myofibroblasts intermixed with loose connective matrix. This pattern is the hallmark of a clinical pathological entity, namely cryptogenic organizing pneumonia (COP) when no cause or etiologic context is found. The process of intraalveolar organization results from a sequence of alveolar injury, alveolar deposition of fibrin, and colonization of fibrin with proliferating fibroblasts. A tremen- dous challenge for research is represented by the analysis of features that differentiate the reversible process of OP from that of fibroblastic foci driving irreversible fibrosis in usual interstitial pneumonia because they may determine the different outcomes of COP and idiopathic pulmonary fibrosis (IPF), respectively. Three main imaging patterns of COP have been described: (1) multiple patchy alveolar opacities (typical pattern), (2) solitary focal nodule or mass (focal pattern), and (3) diffuse infiltrative opacities, although several other uncommon patterns have been reported, especially the reversed halo sign (atoll sign).