Tobacco Use and Quit Attempts Among Methadone Maintenance Clients

Total Page:16

File Type:pdf, Size:1020Kb

Tobacco Use and Quit Attempts Among Methadone Maintenance Clients 34. Tabachnick BG, Fidell LS. Using Multivariate Sta- critical review. Am J Public Health. 1987;77: 38. Zastowny TR, Adams EH, Black GS, Lawton tistics. 3rd ed. NewYork,NY: HarperCollins; 1996. 153–160. KB, Wilder AL. Sociodemographic and attitu- 35. Cohen J, Cohen P. Applied Multiple Regression/ 37. McDivitt JA, Zimick S, Hornick RC. Explaining dinal correlates of alcohol and other drug use Correlation Analysis for the Behavioral Sciences. the impact of a communication campaign to among children and adolescents: analysis of a Hillsdale, NJ: Lawrence Erlbaum; 1983. change vaccination knowledge and coverage in large-scale attitude tracking study. J Psychoac- 36. Flay BR. Mass media and smoking cessation: a the Philippines. Health Commun. 1997;9:95–118. tive Drugs. 1993;25:224–237. Tobacco Use and Quit Attempts Among Methadone Maintenance Clients ABSTRACT Kimber Paschall Richter, PhD, MPH, Cheryl A. Gibson, PhD, Jasjit S. Ahluwalia, MD, MPH, MS, and Kristin H. Schmelzle, MA Objectives. This study examined to- Tobacco-related illness is a major cause of Measures bacco use prevalence, types of tobacco death for people who have undergone treat- used, interest in quitting, and prior quit ment for alcohol or illicit drug use.1,2 Smok- The self-administered 12-item question- attempts among persons in methadone ing rates appear to be very high among patients naire was designed to place minimal burden maintenance treatment. in methadone maintenance treatment, the treat- on clients and staff. The survey took 3 to 5 Methods. Counselors collected sur- ment of choice for many people with opiate minutes to complete and was anonymous. De- veys from 84% (550 of 655) of all clients addiction. Although no representative data are mographic questions included age, sex, high- in a 4-county metropolitan area. available, several surveys have reported preva- est grade or level of schooling, racial/ethnic Results. Most clients (77%) smoked lence rates of 85% to 98%.3–5 background, and age at which participants first cigarettes. Of the 59 former tobacco users, Approximately a quarter of a million peo- entered methadone treatment. Number of years only 6 reported using a cessation phar- ple in the United States and Europe are enrolled in methadone treatment was calculated by sub- macotherapy to quit.Three quarters of the in methadone maintenance treatment.6 Metha- tracting age at which participants first entered current smokers had attempted to quit at done is one of the most carefully controlled, methadone treatment from current age. This least once, with an average of 5 attempts. monitored, and evaluated pharmacologic treat- figure was an approximation of current smok- Most smokers (80%) were “somewhat” ments in the history of medicine.7 It reduces ers’exposure to methadone treatment, because or “very” interested in quitting. heroin use, opiate-related deaths, criminality, some clients probably cycled in and out of Conclusions. The quit ratio among and rates of HIV infection6 and is associated treatment. methadone maintenance treatment cli- with increased employment and increased use Seven questions about tobacco use were ents was 12%, compared with 50% na- of health and social services.8 However, in na- adapted from the Behavioral Risk Factor Sur- tionwide. To reduce morbidity and mor- tional evaluations of methadone maintenance veillance System, theYouth Risk Behavior Sur- tality, cessation interventions must be treatment,9–11 little to no mention is made of vey, and the Mayo Nicotine Dependence Cen- developed and disseminated. (Am J Pub- monitoring or treating cigarette use among pa- ter Questionnaire.12–14 In general, reliability of lic Health. 2001;91:296–299) tients, even though smoking is associated with tobacco questions from these survey instru- chronic illness and premature death among per- ments is high.15,16 The proportion of tobacco sons with a history of opiate dependence.1 users who had successfully quit (quit ratio) was This study was conducted to establish calculated by dividing the number of former the prevalence of cigarette smoking, and tobacco users by the number of current and for- interest in quitting, among methadone cli- mer tobacco users and then multiplying by 100. ents in a 4-county metropolitan area. Current cigarette smokers were asked to report the age at which they started smoking Methods Kimber Paschall Richter, Jasjit S. Ahluwalia, and Kristin Schmelzle are with the Department of Pre- Subjects ventive Medicine, University of Kansas School of Medicine, Kansas City, and the Kansas Cancer In- Surveys were distributed to clients of stitute. Cheryl A. Gibson and Jasjit S. Ahluwalia are methadone maintenance clinics serving 4 urban with the Department of Internal Medicine, Univer- and suburban counties that span Greater Kansas sity of Kansas School of Medicine. City. Two of the 5 clinics were public programs, Requests for reprints should be sent to Kimber Paschall Richter, PhD, MPH, Department of Pre- 2 were private and for profit, and 1 was pri- ventive Medicine, University of Kansas Medical Cen- vate and not for profit. Eighty-four percent ter, 3901 Rainbow Blvd, Kansas City, KS 66160- (550 of 655) of all clients served by the clinics 7313 (e-mail: [email protected]). completed and returned surveys. This brief was accepted April 13, 2000. 296 American Journal of Public Health February 2001, Vol. 91, No. 2 regularly, the number of cigarettes smoked per power to examine differences in smoking be- former tobacco users, and 11% reported never day, the number of times a quit attempt was haviors between racial/ethnic minority and using any form of tobacco (data not shown). No made that lasted at least 24 hours, their longest White persons. Confidence intervals and hy- significant differences were found between quit attempt, their level of interest in quitting, pothesis tests were constructed with Minitab Whites and people of color regarding propor- and whether they would be interested in at- (Minitab, Inc, State College, Pa) to examine tions of people who currently used tobacco. tending a smoking cessation program offered sex and racial/ethnic differences in tobacco When we analyzed the proportion of smokers through methadone treatment. The number of use. Inferential statistics included χ2 analyses within sex, a higher proportion of women years of smoking was derived by subtracting and t tests. (84%) than men (75%) were current tobacco age at which cigarettes were smoked regularly users (χ2 =5.944, P=.015) (data not shown). from current age. This figure was an approxi- The quit ratio was 12%. Most former to- mation of current smokers’ exposure to to- Results bacco users had quit on their own, without any bacco, because some may have been abstinent aid. Only 6 of the 59 former tobacco users re- for a short or long time. Sample Characteristics ported using any pharmacotherapy to quit smoking: 4 with nicotine patches and 2 with Procedure The majority of participants (52%) were nicotine gum. The quit ratio differed by race/ aged 40 to 49 years (Table 1). The age range ethnicity; 20% of the people of color but only Clinic counselors distributed surveys to was 18 to 86 years. Sixty-three percent of the 10% of the Whites had successfully quit (χ2 = their clients during their routine visits. Clients sample was male. Most respondents (81%) were 7.438, P=.006). returned surveys either to a counselor or to a White. Forty-two percent had some post–high box at the methadone dispensing window. school education.The number of years in meth- Cigarette Use Counselors avoided surveying the same client adone maintenance varied considerably among more than once. participants, with treatment spans of less than The cigarette smoking prevalence rate was 1 year to 37 years.The population was not dis- 77% (Table 2). Most (98%) current tobacco Statistical Analysis tributed homogeneously among clinics; women users smoked cigarettes (data not shown). Only were significantly more likely than men to use 12% of the tobacco users used other tobacco Descriptive statistics were calculated with public clinics (χ2 =10.966, P<.001), and peo- products. Cigarette smokers reported smoking SAS.17 Frequencies and percentages were cal- ple of color were more likely thanWhites to at- an average of 20 (SD=12) cigarettes per day. culated for all categorical variables. Means, tend public clinics (χ2 =32.254, P<.001). No significant differences between males and medians, SDs, and ranges were computed for females were found in number of cigarettes continuous variables. Age was grouped into 5 Tobacco Use smoked. However, people of color smoked categories. We used 5 racial/ethnic categories fewer cigarettes per day than did Whites (av- but in analyses combined these into 2 groups— Among all 550 respondents, 78% cur- erage of 17 and 24, respectively; t=5.72, White and people of color—to maximize rently used some form of tobacco, 11% were P<.001). TABLE 1—Profile of Participants Total Sample Current Tobacco Users Nonusers (N=550)a (n=430)c (n=118) Sociodemographic Characteristicsb No. % No. % No. % Sex Male 346 63 259 60 85 73 Female 202 37 170 40 32 27 Age, y 18–29 27 5 21 5 6 5 30–39 136 25 109 26 27 23 40–49 286 52 222 52 63 54 50–59 84 15 65 15 18 15 ≥60 12 2 9 2 3 3 Racial/ethnic background White 443 81 355 83 88 76 African American 76 14 52 12 22 19 Other 25 5 19 4 6 5 Educational background High school or less 316 58 256 60 60 52 Post–high school 229 42 171 40 56 48 Years in methadone treatmentd 10 0–37 10 0–37 10 0–33 Methadone program type Public 265 48 208 48 56 47 Private 285 52 222 52 62 53 aSubsample sizes for survey items differed slightly owing to nonresponse.
Recommended publications
  • PCSS Guidance: Transfer from Methadone to Buprenorphine
    PCSS Guidance Topic: Transfer from Methadone to Buprenorphine Original Author: Paul P. Casadonte, M.D. Last Updated: 12/5/13 (Maria A. Sullivan, M.D., Ph.D.) Guideline Coverage: TIP #40, Treatment Protocols: Patients dependent on long-acting opioids (pgs. 52-54) Clinical Questions: 1. Which patients receiving methadone should be considered good candidates for transfer to buprenorphine? 2. How should I transition a patient from methadone to buprenorphine? Background: Patients receiving methadone may seek transfer to buprenorphine treatment. There are a large number of clinical scenarios that would cause a patient receiving methadone to seek induction onto buprenorphine. It is incumbent upon the physician to weigh the clinical issues carefully prior to agreeing to assist in the transfer. If a patient is stable on methadone, it is generally not advisable to agree to transfer to buprenorphine without a careful evaluation of the factors motivating the desire to transfer. However, if in the physician's medical judgment, buprenorphine treatment is appropriate and the patient is well-informed of the risks and benefits, transfer may be a reasonable option. Among the potential benefits of transfer to buprenorphine include lower risk of overdose or sedation, lower risk of QT prolongation and ventricular arrhythmias, less severe withdrawal if a dose is missed, the capacity to obtain medication at a local pharmacy and the option of treatment in a doctor's office. A number of factors might motivate a patient's request to transfer from methadone. These
    [Show full text]
  • Methadone Hydrochloride Tablets, USP) 5 Mg, 10 Mg Rx Only
    ROXANE LABORATORIES, INC. Columbus, OH 43216 DOLOPHINE® HYDROCHLORIDE CII (Methadone Hydrochloride Tablets, USP) 5 mg, 10 mg Rx Only Deaths, cardiac and respiratory, have been reported during initiation and conversion of pain patients to methadone treatment from treatment with other opioid agonists. It is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (see DOSAGE AND ADMINISTRATION). Particular vigilance is necessary during treatment initiation, during conversion from one opioid to another, and during dose titration. Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly in the early dosing period. These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration. In addition, cases of QT interval prolongation and serious arrhythmia (torsades de pointes) have been observed during treatment with methadone. Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. Methadone treatment for analgesic therapy in patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone is considered and outweighs the risks. Conditions For Distribution And Use Of Methadone Products For The Treatment Of Opioid Addiction Code of Federal Regulations, Title 42, Sec 8 Methadone products when used for the treatment of opioid addiction in detoxification or maintenance programs, shall be dispensed only by opioid treatment programs (and agencies, practitioners or institutions by formal agreement with the program sponsor) certified by the Substance Abuse and Mental Health Services Administration and approved by the designated state authority.
    [Show full text]
  • Medications to Treat Opioid Use Disorder Research Report
    Research Report Revised Junio 2018 Medications to Treat Opioid Use Disorder Research Report Table of Contents Medications to Treat Opioid Use Disorder Research Report Overview How do medications to treat opioid use disorder work? How effective are medications to treat opioid use disorder? What are misconceptions about maintenance treatment? What is the treatment need versus the diversion risk for opioid use disorder treatment? What is the impact of medication for opioid use disorder treatment on HIV/HCV outcomes? How is opioid use disorder treated in the criminal justice system? Is medication to treat opioid use disorder available in the military? What treatment is available for pregnant mothers and their babies? How much does opioid treatment cost? Is naloxone accessible? References Page 1 Medications to Treat Opioid Use Disorder Research Report Discusses effective medications used to treat opioid use disorders: methadone, buprenorphine, and naltrexone. Overview An estimated 1.4 million people in the United States had a substance use disorder related to prescription opioids in 2019.1 However, only a fraction of people with prescription opioid use disorders receive tailored treatment (22 percent in 2019).1 Overdose deaths involving prescription opioids more than quadrupled from 1999 through 2016 followed by significant declines reported in both 2018 and 2019.2,3 Besides overdose, consequences of the opioid crisis include a rising incidence of infants born dependent on opioids because their mothers used these substances during pregnancy4,5 and increased spread of infectious diseases, including HIV and hepatitis C (HCV), as was seen in 2015 in southern Indiana.6 Effective prevention and treatment strategies exist for opioid misuse and use disorder but are highly underutilized across the United States.
    [Show full text]
  • Methadone Therapy for Opioid Dependence LAURIE LIMPITLAW KRAMBEER, PH.D., WILLIAM VON MCKNELLY, JR., M.D., WILLIAM F
    Methadone Therapy for Opioid Dependence LAURIE LIMPITLAW KRAMBEER, PH.D., WILLIAM VON MCKNELLY, JR., M.D., WILLIAM F. GABRIELLI, JR., M.D., PH.D. and ELIZABETH C. PENICK, PH.D. University of Kansas Medical Center, Kansas City, Kansas The 1999 Federal regulations extend the treatment options of methadone-maintained opi- oid-dependent patients from specialized clinics to office-based opioid therapy (OBOT). OBOT allows primary care physicians to coordinate methadone therapy in this group with ongo- ing medical care. This patient group tends to be poorly understood and underserved. Methadone maintenance therapy is the most widely known and well-researched treatment for opioid dependency. Goals of therapy are to prevent abstinence syndrome, reduce nar- cotic cravings and block the euphoric effects of illicit opioid use. In the first phase of methadone treatment, appropriately selected patients are tapered to adequate steady-state dosing. Once they are stabilized on a satisfactory dosage, it is often possible to address their other chronic medical and psychiatric conditions. The maintenance phase can be used as a long-term therapy until the patient demonstrates the qualities required for successful detox- ification. Patients who abuse narcotics have an increased risk for human immunodeficiency virus infection, hepatitis, tuberculosis and other conditions contributing to increased mor- bidity and mortality. Short- or long-term pain management problems and surgical needs are also common concerns in opioid-dependent patients and are generally treatable in conjunc- tion with methadone maintenance. (Am Fam Physician 2001;63:2404-10.) pioid dependence is a chronic, point in time.2,6,7 Gender differences exist, See editorial on page 2335.
    [Show full text]
  • Methadone and the Anti-Medication Bias in Addiction Treatment
    White, W. & Coon, B. (2003). Methadone and the anti-medication bias in addiction treatment. Counselor 4(5): 58-63. Methadone and the Anti-medication Bias in Addiction Treatment William L. White, MA and Brian F. Coon, MA, CADC An Introductory Note: This article is long overdue. Like many addiction counselors personally and professionally rooted in the therapeutic community and Minnesota model programs of the 1960s and 1970s, I exhibited a rabid animosity toward methadone and protected these beliefs in a shell of blissful ignorance. That began to change in the late 1970s when a new mentor, Dr. Ed Senay, gently suggested that the great passion I expressed on the subject of methadone seemed to be in inverse proportion to my knowledge about methadone. I hope this article will serve as a form of amends for that ignorance and arrogance. (WLW) There is a deeply entrenched anti-medication bias within the field of addiction treatment. This bias is historically rooted in the iatrogenic insults that have resulted from attempts to treat drug addiction with drugs. The most notorious of these professional practices includes: coaching alcoholics to substitute wine and beer for distilled spirits, treating alcoholism and morphine addiction with cocaine and cannabis, switching alcoholics from alcohol to morphine, failing repeatedly to find an alcoholism vaccine, employing aversive agents that linked alcohol or morphine to the experience of suffocation and treating alcoholism with drugs that later emerged as problems in their own right, e.g., barbiturates, amphetamines, tranquilizers, and LSD. A history of harm done in the name of good culturally and professionally imbedded a deep distrust of drugs in the treatment of alcohol and other drug addiction (White, 1998).
    [Show full text]
  • ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update
    The ASAM NATIONAL The ASAM National Practice Guideline 2020 Focused Update Guideline 2020 Focused National Practice The ASAM PRACTICE GUIDELINE For the Treatment of Opioid Use Disorder 2020 Focused Update Adopted by the ASAM Board of Directors December 18, 2019. © Copyright 2020. American Society of Addiction Medicine, Inc. All rights reserved. Permission to make digital or hard copies of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for commercial, advertising or promotional purposes, and that copies bear this notice and the full citation on the fi rst page. Republication, systematic reproduction, posting in electronic form on servers, redistribution to lists, or other uses of this material, require prior specifi c written permission or license from the Society. American Society of Addiction Medicine 11400 Rockville Pike, Suite 200 Rockville, MD 20852 Phone: (301) 656-3920 Fax (301) 656-3815 E-mail: [email protected] www.asam.org CLINICAL PRACTICE GUIDELINE The ASAM National Practice Guideline for the Treatment of Opioid Use Disorder: 2020 Focused Update 2020 Focused Update Guideline Committee members Kyle Kampman, MD, Chair (alpha order): Daniel Langleben, MD Chinazo Cunningham, MD, MS, FASAM Ben Nordstrom, MD, PhD Mark J. Edlund, MD, PhD David Oslin, MD Marc Fishman, MD, DFASAM George Woody, MD Adam J. Gordon, MD, MPH, FACP, DFASAM Tricia Wright, MD, MS Hendre´e E. Jones, PhD Stephen Wyatt, DO Kyle M. Kampman, MD, FASAM, Chair 2015 ASAM Quality Improvement Council (alpha order): Daniel Langleben, MD John Femino, MD, FASAM Marjorie Meyer, MD Margaret Jarvis, MD, FASAM, Chair Sandra Springer, MD, FASAM Margaret Kotz, DO, FASAM George Woody, MD Sandrine Pirard, MD, MPH, PhD Tricia E.
    [Show full text]
  • Significantly More Intense Pain in Methadone-Maintained Patients Who Are Addicted to Nicotine
    www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No. 36), pp: 60576-60580 Clinical Research Paper Significantly more intense pain in methadone-maintained patients who are addicted to nicotine Lian-Zhong Liu1,*, Lin-Xiang Tan2,*, Yan-Min Xu1, Xue-Bing Liu1, Wen-Cai Chen1, Jun-Hong Zhu1, Jin Lu3 and Bao-Liang Zhong1 1Affiliated Wuhan Mental Health Center (The Ninth Clinical School), Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China 2Mental Health Education Center, Central South University, Changsha, Hunan Province, China 3Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China *These authors contributed equally to this work Correspondence to: Xue-Bing Liu, email: [email protected] Jin Lu, email: [email protected] Bao-Liang Zhong, email: [email protected] Keywords: pain, smoking, nicotine dependence, heroin dependence, methadone Received: May 30, 2017 Accepted: June 29, 2017 Published: July 13, 2017 Copyright: Liu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Pain and cigarette smoking are very common in heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT) and both have substantial negative effects on HDPs’ physical and mental health. Nevertheless, very few studies have assessed the relationship between the two in HDPs. This study examined the association between pain intensity and smoking in Chinese methadone-maintained HDPs. A total of 603 HDPs were consecutively recruited from three MMT clinics in Wuhan, China, and administered with a socio-demographic and drug use questionnaire, a smoking questionnaire concerning average number of cigarettes smoked daily and Heaviness of Smoking Index, and Zung’s Self-rating Depression Scale.
    [Show full text]
  • Understanding Methadone Maintenance Treatment Under the Steady-State System
    Understanding Methadone Maintenance Treatment Under the Steady-State System What is methadone? Methadone is a synthetic opioid that is used as a medication to treat: (1) opioid addiction, (2) opioid detoxification, and (3) chronic pain. When used to treat opioid addiction, it is referred to as “methadone for maintenance treatment” or MMT. Methadone is taken orally as a pill, tablet, or liquid. When dosed properly, methadone reduces cravings for opioids without creating euphoria, sedation, or an analgesic effect. i Who can receive methadone for maintenance treatment (MMT)? Federal regulations stipulate that to be eligible for MMT, patients must demonstrate at least a one- year history of opioid dependence.ii Patients must generally be at least 18 years old (although certain circumstances allow patients to be at least 16 years old) in order to receive MMT.iii Where can a patient receive MMT? MMT can typically only be dispensed through an opioid treatment program (OTP) certified by the Substance Abuse and Mental Health Services Administration (SAMHSA). Exceptions are made in the event of an emergency (whereby a hospital can dispense MMT) and for office-based physicians who maintain a formal relationship with an OTP (this form of treatment is sometimes referred to as office- based opioid treatment (OBOT)).iv, v In 2016 there were 1,447 public and private accredited and SAMHSA-certified OTPs in the United States.vi How long do patients receive MMT? Treatment lengths vary by patient, but in general the minimum length of treatment for MMT is 12 months.vii Many patients will receive MMT for much longer, however.
    [Show full text]
  • Treatment of Benzodiazepine Dependence
    The new england journal of medicine Review Article Dan L. Longo, M.D., Editor Treatment of Benzodiazepine Dependence Michael Soyka, M.D.​​ raditionally, various terms have been used to define substance From the Department of Psychiatry and use–related disorders. These include “addiction,” “misuse” (in the Diagnostic Psychotherapy, Ludwig Maximilian Univer­ 1 sity, Munich, and Medical Park Chiemsee­ and Statistical Manual of Mental Disorders, fourth edition [DSM-IV] ), “harmful use” blick, Bernau — both in Germany; and T 2 3 Privatklinik Meiringen, Meiringen, Switzer­ (in the International Classification of Diseases, 10th Revision [ICD-10] ), and “dependence.” Long-term intake of a drug can induce tolerance of the drug’s effects (i.e., increased land. Address reprint requests to Dr. Soyka at Medical Park Chiemseeblick, Rasthaus­ amounts are needed to achieve intoxication, or the person experiences diminished strasse 25, 83233 Bernau, Germany, or at effects with continued use4) and physical dependence. Addiction is defined by com- m . soyka@ medicalpark . de. pulsive drug-seeking behavior or an intense desire to take a drug despite severe N Engl J Med 2017;376:1147-57. medical or social consequences. The DSM-IV and ICD-10 define misuse and harm- DOI: 10.1056/NEJMra1611832 ful use, respectively, on the basis of various somatic or psychological consequences Copyright © 2017 Massachusetts Medical Society. of substance use and define dependence on the basis of a cluster of somatic, psychological, and behavioral symptoms. According to the ICD-10, dependence is diagnosed if 3 or more of the following criteria were met in the previous year: a strong desire or compulsion to take the drug, difficulties in controlling drug use, withdrawal symptoms, evidence of tolerance, neglect of alternative pleasures or interests, and persistent drug use despite harmful consequences.
    [Show full text]
  • Methadone Maintenance for Opioid Use Disorder
    Washington State Institute for Public Policy Benefit-Cost Results Methadone maintenance for opioid use disorder Substance Use Disorders: Medication-assisted Treatment Benefit-cost estimates updated December 2019. Literature review updated December 2016. Current estimates replace old estimates. Numbers will change over time as a result of model inputs and monetization methods. The WSIPP benefit-cost analysis examines, on an apples-to-apples basis, the monetary value of programs or policies to determine whether the benefits from the program exceed its costs. WSIPP’s research approach to identifying evidence-based programs and policies has three main steps. First, we determine “what works” (and what does not work) to improve outcomes using a statistical technique called meta-analysis. Second, we calculate whether the benefits of a program exceed its costs. Third, we estimate the risk of investing in a program by testing the sensitivity of our results. For more detail on our methods, see our Technical Documentation. Program Description: Methadone is an opiate substitution treatment used to treat opioid dependence. It is a synthetic opioid that blocks the effects of opiates, reduces withdrawal symptoms, and relieves cravings. Methadone is a daily medication dispensed in outpatient clinics that specialize in methadone treatment and is often used in conjunction with behavioral counseling approaches. The studies included in our analysis evaluated methadone maintenance rather than short-term detoxification or stabilization. We excluded studies with treatment dosages below standard guidances (< 50 mg/day). Benefit-Cost Summary Statistics Per Participant Benefits to: Taxpayers $1,689 Benefit to cost ratio $2.30 Participants $2,063 Benefits minus costs $5,162 Others $868 Chance the program will produce Indirect $4,503 benefits greater than the costs 82 % Total benefits $9,124 Net program cost ($3,962) Benefits minus cost $5,162 The estimates shown are present value, life cycle benefits and costs.
    [Show full text]
  • Methadone Maintenance
    Methadone Maintenance Judith Martin, MD Medical Director BAART Turk Street Clinic San Francisco, CA Dr. Martin, Disclosures • No conflict of interest to disclose. • No discussion of off-label use. • Special thanks to Dr. Thomas Payte for allowing me to use some of his great slides. Physicians Working in MMT Will Know: • How to safely induce patients to MMT. • How to adjust methadone dosing for maximum effectiveness. • How to detect and manage MMT side effects and medication interactions. • How to work within legal/regulatory framework of 42 CFR part 8. Safety Considerations in MMT: • Avoid sedation and respiratory depression (stay within tolerance) • Minimize side effects of constipation, sweating, hypogonadism • Alertness to potential medication interactions, QT/cardiac risk • Minimize diversion, accidental ingestion or dosing errors Safe Induction: “Start Low go Slow” • Methadone-related deaths during MMT occur during the first 10 days of treatment and are more common with higher induction doses. • There is no way of directly measuring tolerance to methadone. Estimate of opioid tolerance is based on history and physical, supported by toxicology tests. Methadone Deaths in Treatment • Induction risk 7 times greater than active heroin use. Methadone induces its own metabolic rate over time. Eventual dose needed will be usually much higher than initial tolerance. • Most deaths also show benzodiazepines on toxicology. This is true of most unintentional opiate poisonings. Methadone is an Unusual Opioid: • Slow onset of action: patient starts to ‘feel’ the swallowed dose 30-45 minutes later. • Delayed peak action: greatest effect from single dose is 2-4 hours post ingestion. • Tissue stores: methadone deposited in tissue over 3-7 days to reach steady state.
    [Show full text]
  • PATIENT INFORMATION BOOKLET on Methadone MAINTENANCE THERAPY
    PATIENT INFORMATION BOOKLET ON Methadone MAINTENANCE THERAPY VIETNAMESE AND AMERICANS INPARTNERSHIP FIGHT HIV/AIDS In July 2011, FHI became FHI 360. FHI 360 is a nonprofit human development organization dedicated to improving lives in lasting ways by advancing integrated, locally driven solutions. Our staff includes experts in health, education, nutrition, environment, economic development, civil society, gender, youth, research and technology – creating a unique mix of capabilities to address today’s interrelated development challenges. FHI 360 serves more than 60 countries, all 50 U.S. states and all U.S. territories. Visit us at www.fhi360.org. PATIENT INFORMATION BOOKLET ON METHADONE MAINTENANCE THERAPY PATIENT INFORMATION BOOKLET ON Methadone MAINTENANCE THERAPY Adapted from the Methadone Handbook written by Andrew Preston and Mark Doverty for Australian Drug Foundation 1998. Illustrations from the Indonesian and Myanmar translations. For more information also see: http://www.Methadone.org http://www.opiateaddictionrx.info Original English material has been developed with the technical assistance of the World Health Organization (WHO) in Vietnam and translated, compiled, published by the Family Health International in Vietnam (FHI/ Vietnam) with funding from the President’s Emergency Support Program for AIDS relief (PEPFAR) through the Agency for International Development United States (USAID). IntrodUction his hand book contains useful information for people Twho are on a Methadone programme or who are thinking of joining one. It is written primarily for people on long term Methadone maintenance therapy. However, everyone is different and a booklet is no substitute for talking to an expert. If you can’t find the information you need, if you want to know more about something or have any questions or worries, you should talk them over with your counsellor, doctor or dispenser.
    [Show full text]