Scientific Symposium Jaarbeurs, Utrecht

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Scientific Symposium Jaarbeurs, Utrecht Monday, October 29th 2018 Program overview 09.00-09.45 Coffee and registration 09.45-10.00 Welcome by Diana Monissen Chair: Rob Pieters 10.00-11.00 CRISPR Cas 9: a genome engineering technology that revolutionises Emmanuelle Charpentier life sciences and medicine 11.00-11.30 Coffee & Tea 11.30-12.00 Genetic drivers of treatment failure in ALL Charles Mullighan 12.00-12.30 Accelerating therapeutic innovation for children and adolescents with cancer Gilles Vassal 12.30-13.30 Lunch Chair: Monique den Boer 13.30-14.00 Extending CAR T-cell therapy beyond DC19 and B cell malignancies Terry Fry 14.00-14.30 Transparent mice reveal cancer metastasis and drug targeting at single-cell level Ali Ertürk 14.30-14.45 Fellowship Villa Joep Jos Huijbregts 14.45-15.30 Coffee & Tea 15.30-16.00 Mapping the origins of Paediatric and Adult Cancers Richard Gilbertson 16.00-16.30 Systems Medicine Approaches in Neuroblastoma Angelika Eggert 16.30-18.00 Drinks Scientific Symposium Jaarbeurs, Utrecht Tuesday, October 30th 2018 Program overview 08.30-09.00 Coffee and registration Chair: Marry van den Heuvel-Eibrink 09.00-09.30 St Jude as leading example of a comprehensive childhood cancer center James Downing 09.30-10.00 New Directions for Psychosocial Research in Pediatric Oncology Cynthia Gerhardt 10.00-10.30 Creating evidence-based clinical practice guidelines: prevention of fatigue and Lillian Sung management of Clostridium difficile infection in pediatric cancer as examples 10.30-11.00 Coffee & Tea 11.00-11.30 The new biology of anthracycline drugs and how to improve these Sjaak Neefjes 11.30-12.00 Translational control of the cellular stress response in pediatric high-risk tumors Poul Sorensen 12.00-13.00 Lunch Chair: Hans Clevers 13.00-13.20 Tom Voûte Award / Hans Meel 13.20-13.40 Tom Voûte Award / Coco de Koning 13.40-14.00 Tom Voûte Award / Illja Diets 14.00-14.20 Tom Voûte Award / Kirsten Vrenken 14.20-15.00 Coffee & Tea 15.00-15.30 Measuring quality and outcomes in paediatric oncology – what can we learn? Kathy Pritchard-Jones 15.30-16.00 The underappreciated role of hereditary predisposition in Stefan Pfister childhood (brain) tumors 16.00-17.00 How carcinoma cells acquire aggressive traits Robert Weinberg 17.00-17.10 Winner of the Tom Voûte Award 17.10-17.15 Closure by Hans Clevers 17.15-18.30 Farewell drinks.

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The Nobel Prize Sweden.Se
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Premios Nobel 2020
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Emmanuelle Charpentier
8 “It’s really amazing how quickly PHOTO: DEREK HENTHORN FOR MPG; ILLUSTRATION: HENNING BRUER research into CRISPR-Cas9 and its possible applications has developed in recent years.” Max Planck Research · 3 | 2020 NOBEL PRIZE IN CHEMISTRY EMMANUELLE CHARPENTIER CRISPR-Cas9 as an adaptive im- also relatively straightforward in mune system that bacteria and ar- terms of its operation, it’s hard to chaea use to defend themselves imagine laboratory work without it CRISPR-Cas9 contains two molecules of RNA from attacks by viruses. In 2011, nowadays. However, CRISPR-Cas9 that can be combined Emmanuelle Charpentier and her has not only revolutionized basic into a single molecule. research groups, who were con- research, but has also become an A recognition sequence ducting joint research at Umeå indispensable tool in medicine, matching a specific University and the University of biotechnology, and agriculture. In- 9 sequence on the DNA Vienna at the time, described deed, physicians around the world strand directs the enzyme Cas9 to the location where tracrRNA – an RNA molecule that are working flat out to convert the it should cut the strand. activates the CRISPR-Cas9 CRISPR-Cas9 technology into system. A year later, Charpentier therapies for as-yet-untreatable and Doudna published their fin- diseases. Microorganisms with dings describing exactly how modified genetic material are in- CRISPR-Cas9 homes in on the tended to improve the efficiency of correct location in the DNA strand food and medicine production. With some discoveries, it seems like it and how the system can be used as And agricultural crops whose ge- will only be a matter of time before a tool for modifying genetic mate- netic material has been modified they are honored with the Nobel rial.
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Prof. Emmanuelle Charpentier (France) Dr. Jennifer
“Life Science” field of RNA, including the elucidation of the three-dimensional structure of ribozyme crystals. Achievement : Elucidation of the genome editing mechanism From 2002, she has worked as a professor at the University of by the CRISPR-Cas California, Berkeley. Since she became aware of the hypothesis about Prof. Emmanuelle Charpentier (France) CRISPR’s potential role in the adaptive immunity of bacteria around Born: December 11, 1968 (Age 48) 2005, she had been conducting research to elucidate the role of RNA Director, Max Planck Institute for Infection Biology (Berlin) in the defense mechanism of cells. Looking back, Dr. Doudna feels that upon meeting Prof. Charpentier, Dr. Jennifer A. Doudna (USA) intuition told her they could complement each other through joint Born: February 19, 1964 (Age 52) research. Thus began a long distance research collaboration bridging Professor, University of California, Berkeley Northern Europe and the West Coast of the United States, which soon produced results that would astonish the world. Summary Genome editing using the CRISPR-Cas system, announced by Prof. Emmanuelle Charpentier and Dr. Jennifer Doudna in 2012, is a The birth of a genome editing technology revolutionary new technology in genetic engineering. It was adopted that enables us to freely rewrite DNA at an explosive rate as a useful tool for research in the life sciences. Today, it continues to be applied to research in a wide range of fields, Already in June of the year following their first meeting, the joint such as breeding, drug development and medicine. This technology research group used the DNA of streptococcus pyogenes provided by was developed in the process of elucidating the bacterial defense Prof.
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