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Original (PDF) Translational & M olecular I maging I nstitute 6th Annual Symposium April 22, 2016 New York, NY Table of Contents Symposium Schedule ………………………………………………….……………………………………………………………………..............……… 1 Message from the Director ……………………………………………..………………..…………….……..…………………….....…………........... 3 Translational and Molecular Imaging Institute ……………………………………………………………………………………….................… 5 Human Imaging Core ……………………………………………………………………………………………………………................……….. 9 Small Animal Imaging Core …………………………………………………………………………………………………...............………… 13 TMII Research Laboratories ………………………………………………………………………………………................…………………… 16 Biographies of Invited Speakers ……………………………...…………………………………………………………………………...........…....... 21 Zahi A. Fayad, PhD …………………………………………………………..…………………………………………………………...........……….. 23 Dennis S. Charney, MD …………………………………………..………………………..……………………………………............…………... 25 Burton P. Drayer, MD …………………………………………..………………………..……………………………………............…………... 27 Bruce Fischl, PhD ..................………………………………………………….…………………………………………..………….........….... 29 Julie Price, PhD …....………………………………………………………………………………………………………………………............... 31 Mark Griswold, PhD ………………………………………………………………………………………………………...............……………... 33 Anna Moore, PhD ………….…………………………………………………………………………………...............…………………….......... 35 Debiao Li, PhD .................………………………………………………………………………………………………………...............……... 37 Abstracts Selected for Oral Presentation ………………………………………………………………………………………………................ 39 Neuroimaging …....……………………………………………………………………….……………………………………………..................... 41 Cancer/Body Imaging .……………………………………………………………………………….......................…………………………….. 43 Nanomedicine ............………………..........................……………………………………………….…………………..........…………….... 45 Cardiovascular Imaging ….……………………………………………………………….…................……………………………............…. 47 Abstracts Selected for Poster Presentation…………………………………………….....................…………………………………………… 49 Cancer/Body Imaging ….……………………………………………………………….………………………………...............……………….. 49 Cardiovascular Imaging ……………………………………………………………….………………………………........................…….…… 69 Nanomedicine ……..……………………………………………………………………….………………….....................………………………. 99 Neuroimaging …....…………………………………………………………….........................................………….……………………...... 115 Sponsors & Contributors ……..………………………………………………………….……………………..........……………………………....... 151 TMII 2015/16 Highlights ..……………………………………………………………….……………………..........……………………………....... 157 Davis Auditorium – Leon and Norma Hess Center for Science and Medicine Icahn School of Medicine at Mount Sinai – April 22, 2016 SYMPOSIUM SCHEDULE 7:00am – 8:00am Check-in / Walk-up Registration / Poster Set-up (2nd floor) Refreshments and Light Breakfast OPENING REMARKS 8:00am – 8:15am Zahi A. Fayad, PhD (Director, Translational & Molecular Imaging Institute) 8:15am – 8:30am Dennis Charney, MD (Dean, Icahn School of Medicine at Mount Sinai) KEYNOTE ADDRESS – Moderator: Prantik Kundu, PhD 8:30am – 9:30am Bruce Fischl, PhD, (Harvard Medical School; Boston, MA) “Computational analysis of functional, connectional and architectonic properties of the human brain with” 9:30am – 10:00am Break SESSION I – NEUROIMAGING – Moderator: Priti Balchandani, PhD 10:00am – 10:45am Julie Price, PhD (University of Pittsburg; Pittsburg, PA) “In vivo PET imaging of protein targets in Alzheimer’s disease” 10:45am – 11:00am Alan Seifert, PhD (Icahn School of Medicine at Mount Sinai; New York, NY) “DANTE-EPI for CSF Suppression in Cervical Spinal Cord BOLD fMRI at 7T” SESSION II – CANCER & BODY IMAGING – Moderator: Bachir Taouli, MD 11:00am – 11:45am Mark Griswold, PhD (Case Western Reserve University; Cleveland, OH) “Rethinking the way we do MRI: Magnetic Resonance Fingerprinting ” 11:45am – 12:00pm Stefanie Hectors, PhD (Icahn School of Medicine at Mount Sinai; New York, NY) “Assessment of tumor heterogeneity in hepatocellular carcinoma using combined DCE-MRI and BOLD measurements” 1 12:00pm – 1:00pm Lunch POSTER SESSION – Moderators: Sara Lewis PhD, Phil Robson, PhD, Carlos Perez-Medina, PhD, Rafael O’Halloran, PhD, Cheuk Tang, PhD 1:00pm – 2:00pm Poster Viewing SESSION III – NANOMEDICINE – Moderator: Willem Mulder, PhD 2:00pm – 2:45pm Anna Moore, PhD (Harvard Medical School; Boston, MA) “Image-guided Precision Nanomedicine for Cancer Therapy” 2:45pm – 3:00pm Yiming Zhao, PhD (Icahn School of Medicine at Mount Sinai; New York, NY) “Augmenting drug-carrier compatibility improves tumor nanotherapy efficacy” 3:00pm – 3:30pm Break SESSION IV – CARDIOVASCULAR IMAGING – Moderator: Philip Robson, PhD 3:30pm – 4:15pm Debiao Li, PhD (Cedars – Sinai; Los Angeles, CA) “MR Coronary Angiography and Vessel Wall Imaging” 4:15pm – 4:30pm Joseph Lerman (National Heart, Lung & Blood Institute (NHLBI); Bethesda, MD) “Lack of improvement in aortic vascular inflammation is associated with an increase in coronary plaque burden in psoriasis” CLOSING REMARKS & AWARDS 4:30pm – 5:00 pm Burton Drayer, MD (Chair of RadiologY, Icahn School of Medicine at Mount Sinai) 2 Message from the Translational and Molecular Imaging Institute Director I am pleased to welcome you to the 6th Annual Translational and Molecular Imaging Institute (TMII) Symposium. The TMII symposium continues its mission giving researchers and medical professionals an opportunity to gain insight into the current translational imaging research at Mount Sinai and other institutions in and outside the New York metropolitan area. This year we are excited to have the opening lecture by Dr. Bruce Fischl, from Harvard/MGH. Dr. Fischl will speak about new and advanced computational methods for the study of the brain and disease. As in previous years we also invited some of the greatest pioneers in imaging science (Mark Griswold from Case Western; Anna Moore from MGH; Julie Price from the University of Pittsburgh and Debiao Li from Cedars Sinai) to talk to you about some of the innovative research in imaging and drug delivery that they’re pursuing. We received over 50 outstanding abstracts by trainees, faculty and staff from across the NY metro area and beyond. From those we have selected a few exceptional examples, of what we think represent new and exciting developments in the field, to give short oral presentations. We encourage you to attend each of the sessions along with the poster presentations and take advantage of the expertise and enthusiasm these researchers have to offer. Please take the time to review the program book to learn more about the speakers, TMII, its faculty and the resources it has to offer. The symposium is being held at the main Mount Sinai campus, located on the famed Museum Mile. We hope that you get a chance to take in these fine art institutions and tour the TMII facilities. Enjoy the symposium. Zahi A. Fayad, PhD TMII Director Mount Sinai Endowed Chair in Medical Imaging and Bioengineering Professor of Radiology and Medicine (Cardiology) 3 4 Translational and Molecular Imaging Institute 5 6 Our mission is centered around development, validation, translation and education of innovative technology in biomedical imaging to address both basic and clinical research problems and therefore improve human health. The Translational and Molecular Imaging Institute (TMII) is a state of the art research facility housed in ~ 20,000 square feet in the Center of Science and Medicine (CSM). TMII (Director, Zahi A. Fayad, PhD) is comprised of faculty, staff and trainees responsible for coordinating and executing all research projects performed in these facilities. Currently TMII has over 50 members with expertise in all aspects of translational imaging research. The faculty consists of Biomedical and Electrical Engineers and Radiologists who are leading experts in neuroimaging, cardiovascular imaging, body/cancer imaging, and nanomedicine. Highly skilled staff provides a full suite of support services for image acquisition, image analysis, scheduling and performance of the proposed experiments. Access to the TMII facility is based on a fee for service schedule (https://tmii.mssm.edu/imaging- core/resource-fees/). These user fees are calculated to cover the operating and maintenance costs of the instruments and related Core expenses. These rates are determined and periodically reviewed by the Dean’s Office and adjusted to reflect the actual costs. User fees include technical support for operation of imaging equipment. For internal Mount Sinai users, resource usage time is compiled from the web-based scheduling system and charged directly to your account on a monthly basis. Any questions on the charges should be addressed to the TMII Director. The user fee listed in https://tmii.mssm.edu/imaging-core/resource-fees includes support for: Study Start-up Study design/ IRB review & consultations Maintenance self-scheduling system Scan Protocol Scan parameter Implementation/ Optimization (HiRes Structural, DTI, EPI ...) Adaptation of C2P sequences to our scanners Task Protocol fMRI Software administration (Eprime, PsychToolBox, PschoPy(thon), Matlab, Cogent) Basic task modifications (Triggering, Physio monitoring control, etc) Stimulus Equipment Visual (LCD, 3D goggles) Audio (Headphones, ear buds) Eye-tracking equipment (not software control support Physiological Set up (SpO2, Heart rate, Respiration, ECG, GSR, EMG, Skin Temperature) Monitoring 7 Data Handling Long-term online image archive (XNAT) Burn anonymized data to CD for external sites Data Analysis Computer
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