TPSB2 (Human) ELISA Kit the Main Isoenzymes Expressed in Mast Cells, Whereas in Basophils, Alpha-Tryptases Predominate

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TPSB2 (Human) ELISA Kit the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases Catalog Number: KA5074 have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. Regulatory Status: For research use only (RUO) [provided by RefSeq] Product Description: TPSB2 (Human) ELISA Kit is a sandwich enzyme-linked immunosorbent assay for the quantitative measurement of human TPSB2. Calibration Range: 156 to 10000 pg/mL Reactivity: Human Applications: Quant (See our web site product page for detailed applications information) Protocols: See our web site at http://www.abnova.com/support/protocols.asp or product page for detailed protocols Storage Instruction: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles. Entrez GeneID: 64499 Gene Symbol: TPSB2 Gene Alias: TPS2, TPSB1, tryptaseC Gene Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be Page 1/1 Powered by TCPDF (www.tcpdf.org).

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