DOCSLIB.ORG

FINAL for DISTRIBUTION, Interventions to Improve Oral

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
FINAL for DISTRIBUTION, Interventions to Improve Oral Adherence and Oral Therapies in Lymphoma and CLL: A Lymphoma Research Foundation Workshop October 19, 2017 Welcome Meghan Gutierrez Chief Executive Officer Lymphoma Research Foundation Workshop Co-Chairs Jonathan Friedberg, MD, MMSc James P. Wilmot Cancer Institute, University of Rochester Michael Williams, MD, ScM University of Virginia Cancer Center Workshop Steering Committee Christopher Flowers, MD Winship Cancer Institute of Emory University Neil Kay, MD Mayo Clinic Rochester John P. Leonard, MD Weill Cornell Medicine and New York Presbyterian Sonali Smith, MD The University of Chicago Workshop Background • Oral Therapies in Lymphoma Workshop convened Fall 2015 in Washington, D.C. • First multi-stakeholder meeting to explore changing nature of lymphoma/CLL treatment, implications of oral therapies • Expert presentations and discussion outlined key issues, opportunities, and challenges facing the community Workshop Findings • Three core themes emerged from the 2015 workshop: • Impact of oral therapies on a heterogeneous disease like lymphoma is vast and therefore can serve as a case study for other cancers • Numerous challenges including adherence, monitoring, toxicity management, patient education, and cost • Research plays essential role in ensuring HCPs and patients have the information and treatment choices required to maximize outcomes and ensure quality of life Workshop Findings • Adherence focus areas: • Challenges related to adherence highly complex and difficult to quantify • Numerous barriers exist to accurately measure adherence • Existing methods of adherence assessment and emerging technologies could eventually play role in both measuring and supporting patient adherence • Little data exists on the clinical impact of adherence Program Goals • Review epidemiology/forms nonadherence, methods of adherence assessment, and barriers to accurately measuring adherence • Identify primary causes of nonadherence as well as related adherence interventions and tools • Discuss the design and implementation of studies focused on adherence in lymphoma/CLL Workshop Agenda 9:15 AM Patient Adherence and Oral Anticancer Treatment Joseph Greer, PhD, Massachusetts General Hospital 10:00 AM Utilization and Adherence of Oral Anticancer Agents: Perspectives and Opportunities from the National Cancer Institute (NCI) Wendy Nelson, PhD, MPH, Basic Biobehavioral and Psychological Sciences Branch, NCI 10:20 AM Adherence in the TKI Era, or How to Run the CML Marathon Michael J. Mauro, MD, Weill Cornell Medical College 10:45 AM Break 11:00 AM Oral Therapies and Adherence in Lymphoma Roundtable Moderated by Drs. Williams and Friedberg Christopher Flowers, MD, Winship Cancer Institute of Emory University John P. Leonard, MD, Weill Cornell Medical Center Sonali Smith, MD, The University of Chicago 12:15 PM Summary and Next Steps: Areas and priorities for future investigation 12:30 PM Lunch Patient Adherence & Oral Anticancer Treatment Joseph Greer, Ph.D. Program Director, Center for Psychiatric Oncology & Behavioral Sciences Associate Director, Cancer Outcomes Research Program Overview Review rates and correlates of adherence to oral chemotherapy Discuss development of a mobile app intervention to improve symptom monitoring and adherence to oral chemotherapy Describe results of an randomized controlled trial of the mobile app intervention Background The increased use of oral chemotherapy has revolutionized cancer care through improved: • Disease outcomes and patient survival • Convenience of treatment administration • Quality of life by avoiding problems with IV infusion However, patients generally receive less supervision and support for adherence and monitoring of side effects as opposed to directly- observed infusion chemotherapy. Background • Documentation of oral versus IV chemotherapy plans in 175 patients with metastatic NSCLC • ASCO Quality Oncology Practice Initiative Greer et al. J Oncol Pract, 2014 Background Rates of adherence to oral cancer therapies range from 16% to 100% A variety of patient, clinician, treatment, and system factors are associated with non-adherence Ruddy et al. CA: A Cancer Journal for Clinicians, 2009 Greer et al. The Oncologist, 2016 Background 51 studies on rates and/or correlates of adherence (ranging from 46% to 100%) • Methods of adherence assessment included: -plasma level (n=1) -medical chart review (n=3) -electronic monitoring (n=7) -pill count (n=5) -pharmacy/insurance records (n=32) -self report by patient (n=25), physician (n=7), family (n=3) Greer et al. The Oncologist, 2016 Background Pilot study of 90 patients Percentage of Patients with Greater than with CML, metastatic 90% Adherent to Oral Chemotherapy NSCLC, RCC, BC 90 80 • Adherence per MEMS 70 – Mean = 89.3% 60 50 – Less than 90% = 25.6% 40 30 • Predictors of better 20 adherence: 10 – Improved symptom distress, 0 mood, QOL, satisfaction with CML NSCLC RCC BC providers and treatment, and perceived burden to others Jacobs et al. J Oncol Pract, 2017 Specific Aims To develop a patient-centered, smartphone mobile app for individuals with cancer prescribed oral chemotherapy To test the effect of the mobile app on the following: • Adherence to oral chemotherapy • Symptoms and treatment side effects • Quality of life • Satisfaction with cancer care Research Design & Methods Two phase study: • Mobile app development (year 1) • Randomized controlled trial (years 2 and 3) Multidisciplinary team of medical oncologists, psychologists, psychiatrist, and health technology eXperts Stakeholder engagement throughout the study Stakeholder Engagement: FOCUS GROUPS BIANNUAL UPDATESBIANNUAL GROUPS FOCUS Cancer Oncology Practice Clinicians Settings Health System, Community, Patients/ and Society Family Mobile App Development Trial and Data Collection Preliminary Analyses FOCUS GROUPS FOCUS Patients/ Health System, Family Oncology Cancer Community, Clinicians Practice and Society Settings Complete Analyses Prepare Dissemination Research Design & Methods Patient Eligibility Criteria: • Adult (age 18 or older) • Diagnosis of cancer with current prescription for oral chemotherapy • Receiving cancer care at MGH or community affiliate • Possess mobile smartphone (iOS or Android) Research Design & Methods Study Outcomes • Medication adherence (Self-Report & MEMS) • Symptoms and treatment side effects (MDASI) • Quality of Life (FACT-G) • Satisfaction with cancer care (FACIT-TS) Phase 1: Mobile App Development Multistep Process • Initial interviews with patients and clinicians Theory • Software development Design & • User-testing Development • Roll-out User Testing/ • Ongoing upgrades Quality Assurance Deployment/ Maintenance Phase 1: Mobile App Development Group Feedback Implementation Patients and Families “Connect patients with the Feature: Education Library Module - Resources and Social same disease type for social Networking support.” App includes a list of reputable, disease-specific resources for patients looking to connect with others. Healthcare “Provide patients with Feature: Symptom Reporting Module Representatives anchors and definitions of When a patient reports a symptom, app asks several questions symptoms so they can appropriately determine the about the frequency and duration before providing tailored feedback. severity and urgency of their symptoms.” Oncology Clinicians “The weekly symptom Feature: Symptom Reporting Trends Module reports that are sent to Weekly Symptom Reports provide a list of symptoms reported clinicians should be concise and easy to understand.” by the patient, as well as a color and numeric value (1-10) denoting severity. Practice Administrators “Provide resources and Feature: Symptom Reporting Module –“Touch to call clinical contact information for team” feature patients to use when they miss a dose of their Patients are provided with the study team contact information at baseline. Embedded in the symptom reporting feature is a medication.” “touch to call” button for their specific clinic. Phase 1: Mobile App Development App Components: • Chemo treatment plan • Weekly symptom and adherence reporting • Education library • Results feedback to oncology clinicians • Energy Tracking • Healthy Recipes • Social Networking Sites Phase 1: Mobile App Development Phase 2: RCT Study Design Baseline Data Collection R A Smartphone Mobile Post assessment 181 adult N App Intervention at approximately patients D (n=91) 12 weeks prescribed O oral M chemotherapy I Post assessment with access to Z Usual Care Control at approximately a Smartphone E Group (n=90) 12 weeks D Phase 2: RCT Results Approached (n=500) No Smartphone (n=178) Declined (n=110) Enrolled (n=212) Dropped out (n=28) Lost to follow-up (n=3) Baseline Assessment (n=181) Mobile App (n=91) Usual Care (n=90) Post Assessment (n=80) Post Assessment (n=89) • Withdrew (n=7) •Deceased (n=1) • Deceased (n=3) • Lost to follow-up (n=1) MEMS Cap Collected (n=85) •Did not return (n=4) MEMS Cap Collected (n=84) •Data lost (n=1) • Did not return (n=6) • Lost in mail (n=1) Phase 2: RCT Results Sample Demographics Mean (SD) or From 2/13/15 - 12/31/16, N (%) Age Mean (SD) 53.5 (12.9) we enrolled and Female 94 (53.6) randomized 181 patients Race in a trial comparing oral Caucasian 159 (87.8) chemotherapy mobile Asian 10 (5.5) African American 5 (2.8) app to usual care. Hispanic/Latino/a 4 (2.2) Multiracial 2 (1.1) • At baseline, 22% of Other 1 (0.6) patients reported either Ethnicity forgetting or having Hispanic 4 (2.2) problems remembering Cancer Type Hematologic 60 (33.1) to take oral Lung 33 (18.2)
Load more

Recommended publications
  • Download Product Insert (PDF)
    PRODUCT INFORMATION Radotinib Item No. 19923 CAS Registry No.: 926037-48-1 Formal Name: 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5- (trifluoromethyl)phenyl]-3-[[4-(2-pyrazinyl)-2- N pyrimidinyl]amino]-benzamide H N Synonym: IY-5511 N N MF: C H F N O N N N 27 21 3 8 O FW: 530.5 H N Purity: ≥98% UV/Vis.: λmax: 215, 270 nm CF3 Supplied as: A crystalline solid Storage: -20°C Stability: ≥2 years Information represents the product specifications. Batch specific analytical results are provided on each certificate of analysis. Laboratory Procedures Radotinib is supplied as a crystalline solid. A stock solution may be made by dissolving the radotinib in the solvent of choice. Radotinib is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of radotinib in these solvents is approximately 10 and 3 mg/ml, respectively. Description Radotinib is a selective second generation tyrosine kinase inhibitor that targets both the wild-type and mutant forms of Bcr-Abl, with an IC50 value of 30.6 nM in Ba/F3 human chronic myeloid leukemia cells expressing the wild-type form.1 Radotinib also inhibits platelet-derived growth factor receptors (PDGFRs) α 2,3 and β with IC50 values of 75.5 and 130 nM, respectively. Binding of radotinib to Bcr-Abl in vitro inhibits the phosphorylation of the downstream signaling mediator CrkL.3 In acute myeloid leukemia cells, in vitro treatment with radotinib at doses of 10-100 µM reduces viability, activates the mitochondrial apoptosis pathway, and promotes expression of the differentiation marker CD11b.2 References 1.
    [Show full text]
  • Radotinib Induces Apoptosis of Cd11b+ Cells Differentiated from Acute Myeloid Leukemia Cells
    RESEARCH ARTICLE Radotinib Induces Apoptosis of CD11b+ Cells Differentiated from Acute Myeloid Leukemia Cells Sook-Kyoung Heo1, Eui-Kyu Noh2, Dong-Joon Yoon1, Jae-Cheol Jo2, Yunsuk Choi2, SuJin Koh2, Jin Ho Baek2, Jae-Hoo Park3, Young Joo Min2, Hawk Kim1,2* 1 Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, 682-060, Republic of Korea, 2 Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, 682-714, Republic of Korea, 3 Department of Hematology and Oncology, Myongji Hospital, Gyeonggi-do, 412-270, Republic of Korea * [email protected] Abstract Radotinib, developed as a BCR/ABL tyrosine kinase inhibitor (TKI), is approved for the sec- OPEN ACCESS ond-line treatment of chronic myeloid leukemia (CML) in South Korea. However, therapeutic Citation: Heo S-K, Noh E-K, Yoon D-J, Jo J-C, Choi effects of radotinib in acute myeloid leukemia (AML) are unknown. In the present study, we Y, Koh S, et al. (2015) Radotinib Induces Apoptosis of demonstrate that radotinib significantly decreases the viability of AML cells in a dose-de- CD11b+ Cells Differentiated from Acute Myeloid Leukemia Cells. PLoS ONE 10(6): e0129853. pendent manner. Kasumi-1 cells were more sensitive to radotinib than NB4, HL60, or THP- doi:10.1371/journal.pone.0129853 1 cell lines. Furthermore, radotinib induced CD11b expression in NB4, THP-1, and Kasumi- Academic Editor: Rajasingh Johnson, University of 1 cells either in presence or absence of all trans-retinoic acid (ATRA). We found that radoti- Kansas Medical Center, UNITED STATES nib promoted differentiation and induced CD11b expression in AML cells by downregulating Received: March 30, 2015 LYN.
    [Show full text]
  • Atezolizumab Plus Nab-Paclitaxel As First-Line Treatment for Unresectable, Locally Advanced Or Metastatic Triple-Negative Breast
    Articles Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial Peter Schmid*, Hope S Rugo*, Sylvia Adams, Andreas Schneeweiss, Carlos H Barrios, Hiroji Iwata, Véronique Diéras, Volkmar Henschel, Luciana Molinero, Stephen Y Chui, Vidya Maiya, Amreen Husain, Eric P Winer, Sherene Loi, Leisha A Emens, for the IMpassion130 Investigators† Summary Lancet Oncol 2020; 21: 44–59 Background Immunotherapy in combination with chemotherapy has shown promising efficacy across many different Published Online tumour types. We report the prespecified second interim overall survival analysis of the phase 3 IMpassion130 study November 27, 2019 assessing the efficacy and safety of atezolizumab plus nab-paclitaxel in patients with unresectable, locally advanced or https://doi.org/10.1016/ metastatic triple-negative breast cancer. S1470-2045(19)30689-8 See Comment page 3 Methods In this randomised, placebo-controlled, double-blind, phase 3 trial, done in 246 academic centres and *Contributed equally community oncology practices in 41 countries, patients aged 18 years or older, with previously untreated, histologically †Investigators are listed in the documented, locally advanced or metastatic triple-negative breast cancer, and Eastern Cooperative Oncology Group appendix performance status of 0 or 1 were eligible. Patients were randomly assigned (1:1) using a permuted block method Barts Cancer Institute, Queen Mary University of London, (block size of four) and an interactive voice–web response system. Randomisation was stratified by previous taxane London, UK (Prof P Schmid MD); use, liver metastases, and PD-L1 expression on tumour-infiltrating immune cells.
    [Show full text]
  • Early Subclinical Biomarkers in Onco-Cardiology to Prevent
    maco har log P y: r O la u p Yajun et al., Cardiovasc Pharm Open Access 2016, 5:3 c e n s a A v c o DOI: 10.4172/2329-6607.1000183 c i e d r s a s C Cardiovascular Pharmacology: Open Access ISSN: 2329-6607 Review Article OpenOpen Access Access Early Subclinical Biomarkers in Onco-Cardiology to Prevent Cardiac Death Yajun Gu1, Bumei Zhang2, Hongwei Fu1,3, Yichao Wang1 and Yunde Liu1* 1School of Medical Laboratory, Tianjin Medical University, Tianjin, China 2Department of Family Planning, the Second Hospital of Tianjin Medical University, Tianjin, China 3Tianjin Medical University General Hospital, Tianjin, China Abstract Recent oncologic treatment has been associated with cardiovascular complications, such as hypertension, metabolic derangements, thrombosis, arrhythmia, and even cardiac death. Careful attention to detailed cardiac evaluation is required to optimize the anticancer treatment and prevent heart failure of patients undergoing chemoradiotherapy. Classical cardiovascular biomarkers like ANP, BNP, ProANP, NT-ProBNP, hsTnI, hsTnT, adropin, copeptin, and ET-1 are indicative of toxic effects in cancer patients with radiation, chemotherapy, and neoadjuvant treatment. Recently, miRNAs (i.e., miR-29, miR-146, miR-208, and miR-216) in the peripheral blood or exosome- derived miRNAs are attractive as novel biomarkers for drug-induced cardiotoxicity due to their highly conserved sequence and stability in body fluids. The anticancer treatment could lead to detectable increases of miRNAs in the absence of traditional cardiac biomarkers or cardiac remodeling. Circulating cardiovascular biomarkers provide earlier detection of cardiotoxicity from cancer treatments before irreversible damage occurs. An increased understanding of the potential roles and mechanisms may help to reveal the crosstalk between cancer therapy and cardiac issues.
    [Show full text]
  • Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia
    cancers Review Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia Kalpana K. Bhanumathy 1,*, Amrutha Balagopal 1, Frederick S. Vizeacoumar 2 , Franco J. Vizeacoumar 1,3, Andrew Freywald 2 and Vincenzo Giambra 4,* 1 Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; [email protected] (A.B.); [email protected] (F.J.V.) 2 Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada; [email protected] (F.S.V.); [email protected] (A.F.) 3 Cancer Research Department, Saskatchewan Cancer Agency, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada 4 Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapies (ISBReMIT), Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, FG, Italy * Correspondence: [email protected] (K.K.B.); [email protected] (V.G.); Tel.: +1-(306)-716-7456 (K.K.B.); +39-0882-416574 (V.G.) Simple Summary: Protein phosphorylation is a key regulatory mechanism that controls a wide variety of cellular responses. This process is catalysed by the members of the protein kinase su- perfamily that are classified into two main families based on their ability to phosphorylate either tyrosine or serine and threonine residues in their substrates. Massive research efforts have been invested in dissecting the functions of tyrosine kinases, revealing their importance in the initiation and progression of human malignancies. Based on these investigations, numerous tyrosine kinase inhibitors have been included in clinical protocols and proved to be effective in targeted therapies for various haematological malignancies.
    [Show full text]
  • 1. Recommendations of the Ndac (Oncology and Hematology) Held on 10.12.2011
    1. RECOMMENDATIONS OF THE NDAC (ONCOLOGY AND HEMATOLOGY) HELD ON 10.12.2011:- The NDAC (Oncology and Hematology) deliberated the proposals on 10.12.2011 and recommended the following:- AGENDA NAME OF DRUG RECOMMENDATIONS NO. Global Clinical Trials Recommended for giving permission for clinical trial subject to condition that trasuzumab naive patient arm should be excluded from the study, as patients cannot be left untreated of trastuzumab therapy / or 1 Afatinib treated with only investigational drug. Patients aged 18 to 65 years should be included in the study. Recommended for giving permission for clinical trial subject to the following conditions:- ICD is very extensive and too technical for the 2 Netupitant/ patient to understand. It should be simplified. Palonosetron Definite statistical tests for the comparison of primary and secondary endpoints should be incorporated in the protocol. Recommended for giving permission for clinical trial subject to the following conditions:- Periodic ophthalmic examination should be performed at every visit as the drug is reported to have ophthalmological side effects in 53 % cases in 3 Crizotinib phase 2 study. Patients aged 18 to 65 years should be included in the protocol. Method for causality assessment by the investigator should be included in the protocol. New Drugs Approved with the condition that structured post marketing trial (Phase 4) should be conducted in 4. Indian population. Report of post marketing trials Crizotinib ongoing in other countries when completed should be submitted. 5. Abiraterone Approved with condition of conducting Post Acetate Marketing trial (Phase IV) in Indian population to monitor the adverse effects. Report of post marketing trials ongoing in other countries when completed should be submitted.
    [Show full text]
  • Teratogenic Effect of Radotinib: Case Report JUYOUNG CHEON, JUNG WHAN AHN, KYUNG MIN PARK, GUISERA LEE and YUN SUNG JO
    ANTICANCER RESEARCH 36 : 6599-6602 (2016) doi:10.21873/anticanres.11265 Teratogenic Effect of Radotinib: Case Report JUYOUNG CHEON, JUNG WHAN AHN, KYUNG MIN PARK, GUISERA LEE and YUN SUNG JO Department of Obstetrics and Gynecology, College of Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea Abstract. Background: Simultaneous presentation of Case Report pregnancy and chronic myeloid leukemia (CML) is rare. Tyrosine kinase inhibitors (TKIs) are rarely used in A 19-year-old patient, gravida 1 para 0, was referred for pregnancy. There is almost no information on the effect of amenorrhea for 7 weeks 6 days. The patient had been recently developed TKIs on the fetus. Case Report: A 22- diagnosed with CML 1 year earlier and had been taking year-old woman became pregnant while using radotinib, a 200 mg radotinib twice daily orally for 1 year. Six months novel TKI for CML. She was concerned about the possible before referral, in chronic phase, a complete cytogenic response teratogenic effect of radotinib; hence the first pregnancy was was achieved. Normally, the patient had regular menstruation. terminated. The patient underwent full-term delivery at the The result of urine human chorionic gonadotropin (HCG) test second pregnancy. The infant had facial deformity and was positive and the ultrasound examination showed that G- congenital laryngomalacia. Conclusion: We witnessed sac was 1.26 cm. The fetal pole measured 2.4 mm (5 weeks 5 structural abnormality when the patient used radotinib days of gestation). Fetal heart beat was 105 bpm/min. She was during the first trimester of pregnancy.
    [Show full text]
  • Breakthrough Biomedical Philanthropy
    Breakthrough Biomedical Philanthropy May12, 2016 Why is cancer so hard to cure? Tony Hunter 1971 National Cancer Act National Cancer Act Signed into law by President Nixon December 23, 1971 The Director of National Cancer Institute was given authorities under the act that included: • Create new Cancer Centers and manpower training programs • Appoint advisory committees, allowing the director to explore new issues/opportunities. • Expand the physical location at NIH and other research facilities across the country. • AwardThis contracts was for research Nixon’s “moonshot” to • Collaborate with other federal, state, or local public agencies and private industry • Conduct cancer control activitiescure cancer • Establish an international cancer research data bank that collects, catalogues, stores, and disseminates results of cancer research • Award research grants Since 1971 the NCI has spent over $140 billion on cancer research Cancer remains a scourge worldwide • 14 million cancers diagnosed worldwide in 2012 with 8 million deaths, with half of the cancers occurring in underdeveloped countries • Lung cancer accounts for 20% of all cancers world wide, and breast cancers 10% of all cancers • In the United States,1,665,540 new cancer cases were diagnosed and 585,720 cancer deaths occurred in 2014 Cancer is about to overtake heart disease as the leading cause of death in the US US Mortality Data - 2013 No. of % of all Rank Cause of Death deaths deaths 1. Heart diseases 611,105 32.6 2. Cancer 584,881 30.9 3. Chronic lower respiratory diseases 149,205 7.4 4. Accidents 130,557 6.8 5. Cerebrovascular diseases 117,176 6.4 6.
    [Show full text]
  • Determination of a Radotinib Dosage Regimen Based on Dose–
    Cancer Medicine Open Access ORIGINAL RESEARCH Determination of a radotinib dosage regimen based on dose–response relationships for the treatment of newly diagnosed patients with chronic myeloid leukemia Hayeon Noh1, Su Young Jung2,3, Jae-Yong Kwak4, Sung-Hyun Kim5, Suk Joong Oh6, Dae Young Zang7, Suhyun Lee2,3, Hye Lin Park8, Dae Jin Jo8, Jae Soo Shin8, Young Rok Do9, Dong-Wook Kim10,* & Jangik I. Lee2,3,* 1Department of Pharmacy, College of Pharmacy, Yonsei University, Incheon, Korea 2Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea 3Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea 4Chonbuk National University Medical School & Hospital, Jeonju, Korea 5Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea 6Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea 7Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea 8Central Research Institute, IL-YANG Pharmaceutical Co., Ltd., Yongin, Korea 9Department of Medicine, Dongsan Medical Center, Keimyung University, Daegu, Korea 10Seoul St. Mary’s Hospital, Leukemia Research Institute, The Catholic University of Korea, Seoul, Korea Keywords Abstract Chronic myeloid leukemia, dose determination, dose–response relationship, Radotinib is a second-­generation BCR-ABL1 tyrosine kinase inhibitor approved radotinib, tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia in chronic phase (CP-­CML). Here, using the data from a Phase 3 study conducted in patients with newly Correspondence diagnosed CP-­CML, the dose–efficacy as well as dose–safety relationship analyses Jangik I. Lee, Department of Pharmacy, were performed to determine a safe and effective initial dosage regimen of College of Pharmacy, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul radotinib.
    [Show full text]
  • Kinase Drug Discovery 20 Years After Imatinib: Progress and Future Directions
    REVIEWS Kinase drug discovery 20 years after imatinib: progress and future directions Philip Cohen 1 ✉ , Darren Cross 2 ✉ and Pasi A. Jänne 3 ✉ Abstract | Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. Here, we review the remarkable progress made over the past 20 years in improving the potency and specificity of small-molecule inhibitors of protein and lipid kinases, resulting in the approval of more than 70 new drugs since imatinib was approved in 2001. These compounds have had a significant impact on the way in which we now treat cancers and non- cancerous conditions. We discuss how the challenge of drug resistance to kinase inhibitors is being met and the future of kinase drug discovery. Protein kinases In 2001, the first kinase inhibitor, imatinib, received FDA entered clinical trials in 1998, changed the perception Enzymes that catalyse transfer approval, providing the catalyst for an article with the of protein kinases as drug targets, which had previously of the γ- phosphate of ATP provocative title ‘Protein kinases — the major drug tar- received scepticism from many pharmaceutical com- to amino acid side chains in gets of the twenty- first century?’1. Imatinib inhibits the panies. Since then, hundreds of protein kinase inhibi- substrate proteins, such as serine, threonine and tyrosine Abelson (ABL) tyrosine kinase, which is expressed as a tors have been developed and tested in humans and, at residues. deregulated fusion protein, termed BCR–ABL, in nearly the time of writing, 76 have been approved for clinical all cases of chronic myeloid leukaemia (CML)2 and is use, mainly for the treatment of various cancers (FiG.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • Functional Properties of KIT Mutations Are
    Published OnlineFirst June 10, 2019; DOI: 10.1158/1078-0432.CCR-18-1897 Clinical Trials: Targeted Therapy Clinical Cancer Research Functional Properties of KIT Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia Katherine Tarlock1,2,Todd A. Alonzo3,4,Yi-Cheng Wang4, Robert B.Gerbing4, Rhonda Ries1, Michael R. Loken5, Laura Pardo5, Tiffany Hylkema1, Jason Joaquin1, Leela Sarukkai1, Susana C. Raimondi6, Betsy Hirsch7, Lillian Sung8, Richard Aplenc9, Irwin Bernstein1,2, Alan S. Gamis10, Soheil Meshinchi1,2, and Jessica A. Pollard11,12 Abstract þ Purpose: KIT mutations (KIT ) are common in core bind- (10%) both exons, and 3 (5%) alternative exons. Functional ing factor (CBF) AML and have been associated with varying studies demonstrated that E17, but not E8, mutations result prognostic significance. We sought to define the functional in aberrant KIT phosphorylation and growth. TKI exposure and clinical significance of distinct KIT mutations in CBF significantly affected growth of E17, but not E8, transfected þ pediatric AML. cells. Patients with KIT CBF AML had overall survival similar À Patients and Methods: Following transfection of exon 17 to those with KIT (78% vs. 81%, P ¼ 0.905) but higher þ (E17) and exon 8 (E8) mutations into HEK293 and Ba/F3 relapse rates (RR ¼ 43% vs. 21%; P ¼ 0.005). E17 KIT À cells, KIT phosphorylation, cytokine-independent growth, outcomes were inferior to KIT patients [disease-free survival andresponsetotyrosinekinaseinhibitors(TKI)wereeval- (DFS), 51% vs. 73%, P ¼ 0.027; RR ¼ 21% vs. 46%, P ¼ uated. Clinical outcomes of patients treated on COG 0.007)], although gemtuzumab ozogamicin abrogated this AAML0531 (NCT01407757), a phase III study of gemtuzu- negative prognostic impact.
    [Show full text]