CURRICULUM VITAE - 11/01/2017

NAME: James Francis Howard, Jr., M.D.

OFFICE ADDRESS: Department of Neurology 2200 Physicians Office Bldg., CB#7025 170 Manning Drive The University of North Carolina School of Medicine Chapel Hill, NC 27599-7025

E-MAIL: [email protected]

TELEPHONE: Home: on request Office: 919.966.8168 Admin: 919.966.9281 EMG Laboratory 984.974.1686 Facsimile: 919.966.2922

EDUCATION: • Research Associate in Neuromuscular Disease, University of Virginia School of Medicine, Charlottesville, Virginia, 1978 — 1979 • Resident, Neurology, University of Virginia Hospital, Charlottesville, Virginia, 1975 — 1978 • Intern, Internal Medicine, Albany Medical Center Hospital, Albany, New York, 1974 — 1975 • M.D., University of Vermont School of Medicine, Burlington, Vermont, 1974 • B.A. (Special Honors in Anatomy), University of Vermont, Burlington, Vermont, 1970

EMPLOYMENT HISTORY: • Professor of Neurology and Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; July 1, 1992 to present  James F. Howard Distinguished Professor of Neuromuscular Disease, November, 2003 • Adjunct Professor of Allied Health Sciences, University of North Carolina School of Medicine, Chapel Hill, North Carolina; October 1, 2011 to present • Adjunct Professor of Clinical Sciences (Neurology), North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, January 1, 2005 to present

• Associate Professor of Neurology and Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; July 1, 1985 through June 30, 1992 • Assistant Professor of Neurology and Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina; July 1, 1979 through June 30, 1985 • Instructor in Neuromuscular Disease, University of Virginia School of Medicine, Charlottesville, Virginia; July 1, 1978 through June 30, 1979

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CERTIFICATION AND LICENSURE: • Diplomate, Professional Ski Instructors of America (formerly the United States Eastern Amateur Ski Association), 1969 (currently inactive) • Diplomate, National Board of Medical Examiners, 1975 • Diplomate, American Board of Psychiatry and Neurology, 1980 • Diplomate, American Board of Electrodiagnostic Medicine, 1989 (#0412) • Licensed M.D., Virginia (#0101030059) 1978; North Carolina (#23383) 1979

HOSPITAL APPOINTMENTS: • Attending Physician, University of North Carolina Hospitals, July 1979 to present

PROFESSIONAL SOCIETIES: • American Academy of Neurology, 1975 to present  Fellow, 1986 to present  Active, 1979 — 1986  Junior, 1975 — 1979 • American Association of Neuromuscular & Electrodiagnostic Medicine (formerly the American Association of Electrodiagnostic Medicine and American Association of Electromyography and Electrodiagnosis), 1981 to present  Active, 1981 — 1989  Fellow member by examination, 1989 to present  Board of Directors, 2002 — 2005 • American Board of Electrodiagnostic Medicine  Board of Directors, 2008 — present  Examiner, 2002, 2003, 2009  Exam Supervisor, 2009, 2010, 2012 — 2014 • American Medical Association, 1979 to present • American Neurological Association, 1997 to present • International Brain Research Organization/World Federation of Neuroscientists, 1980 to present • Myasthenia Gravis Foundation of America  Medical/Scientific Advisory Board, 1979 to present  Chair, 2003 — 2005  Vice Chair, 2001 — 2003  Secretary, 1999 — 2001 • New York Academy of Sciences, 1980 to present • North Carolina Medical Society, 1979 to present  Chair, Neurology Section, 1994 • North Carolina Neurological Society, 1979 to present  President, 1994  Vice President, 1993  Board of Directors, 2000 — 2009 • Orange-Durham County Medical Society, 1979 to present • Society for Neurosciences, 1980 to present • Professional Ski Instructors of America, (formerly the United States Eastern Amateur Ski Association), member by examination, 1969 — 1980; currently inactive status

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EDITORIAL BOARDS • Associate Editor (founding), Journal of Clinical Neuromuscular Disease, Lippincott, Williams & Wilkins, 1998 — 2006 • Member, Editorial Board, IgNews: Current Topics in Immunoglobulin Research and Therapy, American Red Cross, 2002 — 2004

GRANTS FUNDED (ACTIVE): • Principal Site Investigator: Safety and Efficacy Study of RA101495 in Subjects with Generalized Myasthenia Gravis. Ra Pharmaceuticals Inc. 2017 – 2019. • Site Investigator: A Study to Evaluate the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy. Vertex Pharmaceuticals Inc. 2017 – 2019. • Global Lead Principal Investigator: A Randomized, Double blind, Placebo Controlled Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX 113 in Patients with Myasthenia Gravis who have Generalized Muscle Weakness. Argenx BVBA. 2017 – 2019. • Principal Site Investigator: Investigations into the role of autoantibodies to the LRP4 protein in patients with Myasthenia Gravis. NIH/Georgia Health Sciences University. 2016 – 2019 • Co-Investigator: Comp B-Surveillance and Research of Muscular Dystrophy and Neuromuscular Disorders. U01DD001116, Centers for Disease Control, and Prevention (CDC), National Center on Birth Defects and Developmental Disabilities (NCBDDD). Whitehead N (PI). 2014 – 2019. • Global Lead Principal Investigator: A randomized, double-blind, placebo-controlled, multi- center study to evaluate the safety and efficacy of eculizumab in subjects with refractory generalized myasthenia gravis (GMG), ECU-301, ECU-302, IND 101,219, EudraCT #2013- 003589-15. Alexion Pharmaceuticals, Inc. Howard JF (PI). 2014 – 2018. • Investigator: Autoimmune mechanisms in a novel Aire-deficient model of peripheral neuropathy. NIH/ Environmental Med, Asthma and Lung Biology, 1-R01-NS079683-01A1, Su, M (PI), 2013 — 2018. • Principal Site Investigator: Duchenne Muscular Dystrophy: Double-Blind Randomized Trial to find the optimum Steroid Regimen (FOR-DMD) NIH/NINDS U01-NS061799-01A2, Griggs B (PI), 2013 — 2021. • Co-Investigator: DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular Dystrophy, NIH R01 NS074057-01A1, Gallippi C (PI), 2011 — 2017. GRANTS SUBMITTED (PENDING): • Principal Site Investigator: Characterization of T cell responses in inclusion body myositis. NIH Exploratory/Developmental Research Grant Program (Parent R21). Guptill, J (PI). GRANTS FUNDED (COMPLETED): • Principal Site Investigator: Exploratory Study of Immunological Profiles in Myasthenia Gravis Subjects that Receive Therapeutic Plasma Exchange. UCB Biosciences. Guptill, J (PI). 2014 — 2015. • Principal Site Investigator: BEL115123: A Randomized, Placebo Controlled, Double Blind Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Belimumab in Patients with Myasthenia Gravis (MG). GlaxoSmithKline Pharmaceuticals, Inc., 2013 — 2015. • Principal Site Investigator: A phase II randomized, double-blinded, controlled trial of methotrexate versus placebo in Myasthenia Gravis patients who are considered steroid dependent. NIH/NINDS (University of Kansas), R01FD003538, Barohn R (PI), 2011 — 2014. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 4

• Investigator: Safety and Feasibility of Transvenous Limb Perfusion with Normal Saline in Human Muscular Dystrophy, Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, NIH/NIAMS 1U54AR056953-01, Powers WJ (PI), 2008 — 2013. • Principal Site Investigator: A Phase II, Randomized, Three-Way Crossover, Placebo- Controlled, Pharmacodynamic Study of CK-2107357 in Patients with Generalized Myasthenia Gravis on Standard Therapy, Cytokinetics, Inc., CY 4023/ NINDS 1RC3NS070670-01; CFDA Number: 93.71, 2011 — 2013. • Co-Investigator: Automated Atlas-based Muscle MRI Quantification in Duchenne Muscular Dystrophy Patients, NC TraCS # 50KR71104, University of North Carolina, Fan Z (PI), 2011 — 2012. • Principal Site Investigator: A randomized, double-blind, placebo-controlled, cross-over, multi-center study of eculizumab in patients with generalized myasthenia gravis (GMG) who have moderate to severe weakness despite treatment with immunosuppressants. Alexion Pharmaceuticals, Inc., C08-001, 2008 — 2012. • Principal Site Investigator: Genome wide association study in Myasthenia Gravis. Myasthenia Gravis Foundation of America, 2010 — 2011. • Consultant: Pilot evaluation of the effects of substance P-saporin (SP-SAP) on chronic pain due to osteoarthritis in companion dogs. (PI: Olby, Natasha & Lascelles, Duncan), Novartis, 2010 — 2011. • Consultant: Development of a technique for measuring canine phrenic nerve conduction velocity. (PI: Olby, Natasha & Matthews, Kyle), NCSU, 2010 — 2011. • Investigator: Pudendal Nerve Function as a Predictor of Female Sexual Function with Sacral Neuromodulation. (PI: Parnell, B.) American Urogynecologic Society, 2010 — 2011. • Investigator: National Center for Canine Models of Duchene Muscular Dystrophy ARRA, NIH/NINDS 3-U24-NS059696-01A1S1, 2009 — 2011 • Sub-Investigator: The Natural History of Infantile Globoid Cell Leukodystrophy. Zymenex A/S, rhGALC-01, 2009 — 2011. • Sub-Investigator: The Natural History of Metachromatic Leukodystrophy. Zymenex A/S, 2008 — 2011. • Principal Investigator: Investigation of the ability of Otelixizumab to inhibit in vitro antigen- specific T cell responses from Myasthenia Gravis patients. GlaxoSmithKline Pharmaceuticals, Inc., MGO113510, 2010. • Consultant: Prednisone Ocular Myasthenia Gravis Trial Planning Grant. NIH, IR34 NS046283- 01A1, 2004 — 2007. • Principal Site Investigator: A prospective, randomized, double-blind, placebo-controlled, parallel group, multicenter, 36 week trial to assess the efficacy and safety of adjunct mycophenolate mofetil (MMF) to maintain or improve symptom control with reduced corticosteroids in subjects with myasthenia gravis. Aspreva Rare Disease Program and F. Hoffman-La Roche Ltd/Inc/AG #WX17798, 2004 — 2006. • Sub-Investigator: Multicenter, double-blind, placebo-controlled, study to evaluate the efficacy and safety of Lenalidomide in the treatment of Complex Regional Pain Syndrome Type 1. Celgene Corporation CC-5013-CRPS-002, 2005 — 2006. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 5

• Safety Monitoring Committee: A Trial of Mycophenolate Mofetil in Myasthenia Gravis. Orphan Products Development Program (FDA) #FD-R-002154-01 and Roche Pharmaceuticals Co #CEL248, 2002 — 2006. • Sub-Investigator: An Open Label Phase II Study of PS-341 Alone or in Combination with Dexamethasone in Patients with Multiple Myeloma Who Have Relapsed Following Front- Line Therapy and are Refractory to Their Most Recent Therapy. Millennium Pharmaceuticals #M34100025, 2001 — 2003. • Co-Principal Site Investigator: Zenarestat Phase III Study for Diabetic Neuropathy. Parke- Davis #1014-01, $8,000/patient, 1998 — 2001. • Co-Investigator: 3,4-Diaminopyridine in Myasthenia Gravis and Lambert-Eaton Syndrome. FDA Orphan Drug Program, $236,218, 04/01/90 — 03/31/93. • Co-Investigator: A Double Blind Multicenter Clinical Trial to Assess the Safety and Efficacy of Cyclosporine in the Treatment of Prednisone Dependent Myasthenia Gravis. Muscular Dystrophy Association, $1500/patient, 1989. • Co-Investigator: A Double Blind Multicenter Clinical Trial to Assess the Safety and Efficacy of Cyclosporine in the Treatment of Prednisone Dependent Myasthenia Gravis. Sandoz Research Institute Study #550, $2,500/patient, 1989. • Investigator: Voice Production Processes Instrumentation System, DRR-BRS Shared Instrumentation Grant. NIH, $90,015, 1989. • Co-Investigator: 3,4-Diaminopyridine in Myasthenia Gravis and Lambert-Eaton Syndrome. Muscular Dystrophy Association, $59,000, 1987. • Co-Investigator: A Double Blind Multicenter Clinical Trial to Assess the Safety and Efficacy of Cyclosporine in the Treatment of Myasthenia Gravis. Muscular Dystrophy Association, $1,500/patient, 1987. • Co-Investigator: A Double Blind Multicenter Clinical Trial to Assess the Safety and Efficacy of Cyclosporine in the Treatment of Myasthenia Gravis. Sandoz Research Institute Study #399, $2,500/patient, 1987. • Principal Investigator: Variations in Neuromuscular Safety Factor. Teacher-Investigator Development Award, NINCDS, NIH, USPHS, $269,085, 01/01/85 — 12/31/89. • Principal Investigator: Variations in Neuromuscular Safety Factor. Jefferson-Pilot Fellowship Award, $12,000, 1984. • Principal Investigator: The Direct Effects of Myasthenic Serum Factors on Neuromuscular Transmission in Myasthenic Muscles. UNC Junior Faculty Development Award, $3,000, 1982. • Principal Investigator: The Direct Effects of Myasthenic Serum Factors on Neuromuscular Transmission in Myasthenic Muscles. UNC Medical Faculty Grant Award, $1,841, 1981. • Principal Investigator: The Direct Effects of Myasthenic Serum Factors on Neuromuscular Transmission in Myasthenic Muscles. UNC Research Council Award, $1,500, 1981. • Principal Investigator: Passive Transfer of Human Myasthenia Gravis to Animals. National Research Service Award, NINCDS, NIH, USPHS, $12,800, 1978.

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PROFESSIONAL SERVICE: Consultantships • Alexion Pharmaceuticals, 2007 to present (non-remunerative) • Alnylam Pharmaceuticals, 2016 to 2017 (non-remunerative) • Alpha Cancer Technologies, 2016 to present (non-remunerative) • American Red Cross, 2002 • Argen-x BVBA, 2016 to present (non-remunerative) • Aventis Pharmaceuticals, Inc., 2003, 2004 • Bayer Corporation, 1996 — 2000, 2002 • Bayhill Therapeutics Inc., 2010 • Catalyst (BioMarin) Pharmaceutical Inc., 2011 — 2014 (non-remunerative) • GlaxoSmithKline, 2009 — 2010 • NIH Physician-Scientist Search Committee for Directorship of EMG Laboratory, 1996 • PDL Biopharma/Facet Biotech, 2008 • Penwest Pharmaceuticals, 2007 • Ra Pharmaceuticals, 2016 to present (non-remunerative) • Sanofi-aventis Pharmaceuticals, 2006 • Sanofi-pasteur Pharmaceuticals, 2005 • Toleranzia AB, 2016 to present (non-remunerative) • ViCRO Corporation, 2000 Directorships • American Board of Electrodiagnostic Medicine  Board of Directors, 2008 to 2016 • American Association of Neuromuscular & Electrodiagnostic Medicine (formerly the American Association of Electrodiagnostic Medicine)  Board of Directors, 2002 – 2005 • American Association of Neuromuscular & Electrodiagnostic Medicine Foundation for Research and Education (formerly the American Association of Electrodiagnostic Medicine Foundation for Research and Education)  Board of Directors, 2002 – 2005 • Myasthenia Gravis Foundation of America  Board of Directors, 2003 – 2006 • Myasthenia Gravis Foundation, Carolinas Chapter  Board of Directors, 1989 – 2011

• Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course)  Course Director, 1998 — 2006 Examiner • American Board of Electrodiagnostic Medicine  Examiner, 2002, 2003, 2009  Exam Supervisor, 2009, 2010, 2012 — 2014 Reviewer (Journals, Grants) • Ad Hoc Grant Reviewer, British Columbia Health Research Foundation, 1992 • Ad Hoc Grant Reviewer, Ministry of Science and Technology, Slovenia, 1995 • Ad Hoc Grant Reviewer, Myasthenia Gravis Foundation of America, High Impact Pilot Projects Program, 2012, 2016, 2017 Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 7

• Ad Hoc Grant Reviewer, Physicians’ Services Inc. Foundation (Ontario, Canada), 2012, 2014 • Ad Hoc Grant Reviewer, NIH Eastern Regional Comprehensive Metabolomic Resource Core, 2016

• Ad Hoc Journal Reviewer, American Heart Journal, 1998 • Ad Hoc Journal Reviewer, American Journal of Physical Medicine & Rehabilitation, 2017 • Ad Hoc Journal Reviewer, Annals of Neurology, 1990, 2015 • Annals of the New York Academy of Sciences, 2017 • Ad Hoc Journal Reviewer, Archives of Neurology, 1987, 1999 • Ad Hoc Journal Reviewer, Archives of Pathology & Laboratory Medicine, 1988, 1990 • Ad Hoc Journal Reviewer, Case Reports in Neurological Medicine, 2015 • Ad Hoc Journal Reviewer, Clinical Immunology and Immunopathology, 1990, 1993, 1998 • Ad Hoc Journal Reviewer, Conference Programs, The New York Academy of Sciences, 1991 • Ad Hoc Journal Reviewer, Experimental Neurology, 2015 • Ad Hoc Journal Reviewer, JAMA Internal Medicine, 2016 • Ad Hoc Journal Reviewer, Journal of Clinical Neuromuscular Disorders, 1999 — 2011 • Ad Hoc Journal Reviewer, Journal of Immunology, 1990 • Ad Hoc Journal Reviewer, Journal of Medical Genetics, 2008 • Ad Hoc Journal Reviewer, Journal of Neurology and Experimental Neuroscience, 2017 • Ad Hoc Journal Reviewer, Journal of the Neurological Sciences, 1994, 1998 — 1999, 2001 — 2006, 2011 — 2013, 2015 • Ad Hoc Journal Reviewer, Mayo Clinic Proceedings, 2008 • Ad Hoc Journal Reviewer, Muscle Nerve, 1990, 1995, 1999 — 2017 • Ad Hoc Journal Reviewer, Neuro-epidemiology, 2014 • Ad Hoc Journal Reviewer, Neurology, 1986, 1997, 1999 — 2004, 2006, 2007, 2009, 2010, 2016, 2017 • Ad Hoc Journal Reviewer, Neuromuscular Disorders, 2008 — 2011, 2014, 2017 • Ad Hoc Journal Reviewer, New England Journal of Medicine, 1990 • Ad Hoc Journal Reviewer, Obstetrics and Gynecology, 1984 • Ad Hoc Journal Reviewer, Paediatric Drugs, 1999 • Ad Hoc Journal Reviewer, Proceedings of the National Academy of Sciences, 1988 • Ad Hoc Journal Reviewer, Southern Medical Journal, 1993 — 1994, 1996 • Ad Hoc Journal Reviewer, Therapeutics and Clinical Risk Management, 2014 Speaker Bureau • Sandoz Pharmaceuticals, 1988-1989

COMMITTEES: International • World Health Organization (WHO)  WHO Advisory Group of the Revision of the ICD-10 Diseases of the Nervous System, 2009 to present  Neuromuscular Junction and Muscle Diseases in Adults • Muscle Study Group  Executive Committee, 2013 — 2016

National - • American Academy of Neurology Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 8

 Alliance for the Decade of the Brain Stamp Committee, 1994 — 1997  Abstract Review Committee  Neuromuscular Section, Annual Meeting for 2010 — 2013 • American Association of Neuromuscular & Electrodiagnostic Medicine (formerly known as American Association of Electrodiagnostic Medicine)  Board of Directors, 2002 — 2005  AANEM Training Liaison (UNC), 1992 to present  North Carolina Liaison Representative to AANEM Professional Standards Committee, 1989 — 2009  Moderator, Single Fiber EMG SIG, 1990 — 1992  SFEMG SIG Liaison to SIG Committee, 1990 — 1992  Chair, SIG Committee, 1992 — 1996  Long Range SIG Planning Committee, 1992 — 1995  Annual Meeting Coordination Committee, 1992 — 1996  Program Committee, 1995 — 1997  Chair, Program Committee, 1996 — 1997  Electronic Media Committee, 1997 — 2000  Website Patient Information Task Force, 2000 — 2001  AANEM, AAN, AAPM&R Steering Committee (Neuromuscular Guidelines Steering Committee), 2000 — 2014  Facilitator, Peripheral Neuropathy Practice Parameter Task Force, 2000 — 2009  Chair, 2010 — 2011  Practice Issues Review Panel (PIRP), 2000 — 2014  Facilitator, Repetitive Nerve Stimulation & SFEMG Task Force, 2009 — 2014  Nominating Committee, 2005 —2008  IVIg Task Force, 2006 — 2010  Research Committee, 2015 to present • American Association of Neuromuscular & Electrodiagnostic Medicine Foundation for Research and Education (formerly American Association of Electrodiagnostic Medicine Foundation for Research and Education)  Board of Directors, 2002 — 2005 • American Board of Electrodiagnostic Medicine  Board of Directors, 2008 to 2016  Credentials Committee, 2008 to present . Chair, 2014 to present  Examination Committee, 2009 to present  Long Range Planning Committee, 2008 — 2011 • American College of Veterinary Internal Medicine (ACVIM)  Small Animal Strategic Planning Committee, 2015 — 2016 • Center for Disease Control (MD Starnet)  Clinical Review Committee, 2014 to present  Coordinating Committee, 2014 to present  Data Sharing Committee, 2014 to present  Surveillance and Research Committee, 2014 to present • Muscular Dystrophy Association  Medical Advisory & Grant Review Committee (MAC), 2001 — 2016 • Myasthenia Gravis Foundation of America  Board of Directors, 2003 — 2006 Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 9

 Board Development Committee, 2004 — 2007  Epidemiological Task Force, 1998 — 2000  Finance Committee, 2004 — 2007  Information Technology Committee, 1998 — 2008  Medical/Scientific Advisory Board, 1981 to present  Chair, Medical/Scientific Advisory Board, 2003 — 2005  Task Force, on MG Study Design, 2010 — 2011  Nominating Committee, 2005 — 2007  Information Technology Committee, 2002 — 2006  Viets Fellowship Subcommittee, 1982 — 2002  Professional Information Subcommittee, 1985 — 1997  Internet Access Committee, Chair, 1995 — 1998  Executive Committee, 1998 — 2006  Chair, Scientific Program Committee, 1998 — 1999  Research and Professional Education Committee, 2005 — 2007  Research & Grants Committee, 2013 to present  Communication Committee, 2010

Regional - • Myasthenia Gravis Foundation, Carolinas Chapter (disbanded in 2016)  Medical Advisory Board, 1981 — 2016  Board of Directors, 1989 — 2011

University of North Carolina, Chapel Hill, North Carolina - • Faculty Council, 1981 — 1984, 1995 — 1998

University of North Carolina School of Medicine - • Continuing Medical Education Committee, 1981 — 1982 • Ad Hoc Committee to review the Task Force on Educational Applications in Medicine (TEAM), 1990 • Post-Tenure Review Committee, 1999 — 2001, 2009 — 2011, 2015 • Ad Hoc Faculty Hearing Committee, 2000 • Committee to Review Promotions to Associate Professor, 2004 — 2008

University of North Carolina School of Medicine, Department of Neurology - • Broyhill Research Award Committee, 1992 to present • Computer Equipment Committee, 1990 — 1996 • Joint Department (Neurology and Neurosurgery) Planning Committee, 1995 — 1996 • Executive Committee, 2001 — 2005 • Resident Education Committee, 2004 — 2007 • Compensation Committee, 2007 — 2009 • Clinic Oversight Committee, 2008 • Strategic Planning Committee, 2008 — 2009  Chair, 2008 — 2009 University of North Carolina Hospitals (UNC HealthCare)- • CPR Committee, 1980 — 1984 • Hospital Infections Committee, 1980 — 1984 • Strategic Planning Committee (Neurosciences subgroup), 2008 Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 10

• Transfusion Committee (Plasma Exchange Subcommittee), 1981 — 2009 • Utilization Review Committee, 1980 — 1983

OTHER ADMINISTRATIVE ACTIVITIES: • Chief, Neuromuscular Disorders Section, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1996 to present. • Director, Neuromuscular Physiology Research Laboratory, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1979 — 1996. • Director, Laboratory for Myasthenia Gravis Research, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1979 to present. • Director, EMG Section, Clinical Neurophysiology Laboratory, University of North Carolina Hospitals, Chapel Hill, North Carolina; 1989 to present. • Director, Clinical Neuromuscular Physiology Training Program, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1995 to present. • Co-Director, Muscular Dystrophy Association Clinic, University of North Carolina Hospitals, Chapel Hill, North Carolina; 1979 to present. • Associate Medical Director, Clinical Neurophysiology Laboratory, University of North Carolina Hospitals, Chapel Hill, North Carolina; 1981 — 1988. • Associate Director, Neuromuscular Unit, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1979 — 1996. • Systems Administrator, Local Area Network (DONLAN), Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1987 — 1998. • Systems Administrator, Local Area Network (CNP1), Clinical Neurophysiology Laboratory, University of North Carolina Hospitals, Chapel Hill, North Carolina; 1987 — 1997. • Webmaster, World Wide Web Homepage, Carolinas Chapter of the National Myasthenia Gravis Foundation of America, 1997 — 2004; founder of the website. • Webmaster, World Wide Web Homepage, National Myasthenia Gravis Foundation of America, 1995 — 1998; founder of the website. • Webmaster, World Wide Web Homepage, Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; 1995 — 2001.

TEACHING RESPONSIBILITIES: MEDICAL STUDENTS (varied activities since 1979) • Yearly participation in First Year Neurobiology course (Myasthenia Gravis and Clinical Correlations), (not 2006) • Yearly participation in Second Year Medicine course on various topics • Yearly participation in Second Year Physical Diagnosis course in Neurology Section, various topics • Yearly participation in Third Year Medicine lecture series, various topics (1979 - 1996) • Major teaching responsibilities to third (1979 to 1996) and fourth (1996 to present) year medical students during neurology ward and consultation services one to three months per year • Preceptorship of third (1979 to 1996; 2006 to present) and fourth (1996 to 2007) year medical students in outpatient clinics • Monthly participation in Fourth Year NeuroSelective lecture series, various topics (1996 — 2005) Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 11

• Participation in Third Year Neurology Lecture Series, neuromuscular topics (2006 to present) • Mentor of Suzanne Biehn Stewart, recipient of Holderness Fellowship and Myasthenia Gravis Foundation Viets Fellowship, Summer 2003

GRADUATE STUDENTS (varied activities since 1979) • Lectures to Pre-and Post-doctoral students and faculty of the Neurobiology Curriculum • Preceptorships in neurophysiology for students of the Neurobiology Curriculum • Preceptorships in neuromuscular disease of childhood for Ph.D. candidates in the Department of Special Education, 1980 — 1986 • Member of Master’s thesis committee of Karen E. Burgess, student of the Graduate Nursing Program, The onset, early treatment, diagnosis and psychosocial effects of myasthenia gravis, 1983 • Member of Doctoral thesis committee of Regina Armstrong, student of the Neurobiology Curriculum, 1987 — 1988 • Member of Doctoral thesis committee of Daniel Wasser, student of the Biomedical Engineering Curriculum, 1989 — 1990 • Mentor of Ingunn Bjornson, M.D., recipient of Unger-Vetlesen Fellowship, 1989 — 1990 • Member, of Doctoral thesis committee of Melissa J. Lewis, VDM, 2016 to present

RESIDENT/FELLOW TRAINING (varied activities since 1979) Neurology • Mentoring of Neuromuscular/EMG Fellow in clinical neuromuscular disease and electrodiagnostic medicine (Electromyography/Neurography) • Participation in Neurological Emergency Care Lecture Series • Participation in Neuroscience Grand Rounds • Participation/Director of Neuromuscular Disease/EMG Lecture Series • Participation/Director of EMG Clinical Case Correlation Series • Preceptorships of neurology resident during attending rotation • Preceptorships in general neurology outpatient clinic • Preceptorships in Neuromuscular Disorders Clinic • Preceptorships in Electrodiagnostic Medicine (Electromyography/Neurography) in the Clinical Neurophysiology Laboratory Family Practice • Preceptorships of family practice residents on attending rotation and outpatient clinics (various times) Medicine • Lectures to Department of Medicine Housestaff for medical emergency lecture series, neuromuscular diseases (various times and amounts) • Lectures to Division of Pulmonary Medicine on the critical care of neuromuscular disorders and disorders of neuromuscular transmission in the ICU setting (various times and amounts) • Participation in Department of Medicine Residents Report (various times and amounts) • Participation in Department of Medicine Grand Rounds (various times and amounts) • Preceptorships of medicine residents and interns on attending rotation and outpatient clinics Ophthalmology • Lectures to Department of Ophthalmology on disorders of neuromuscular transmission (various times and amounts) Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 12

Physical Medicine and Rehabilitation • Preceptorships of PM&R residents in Neurology Outpatient Clinics (1997 — 2001) • Preceptorships of PM&R residents in Electrodiagnostic Medicine (Electromyography/Neurography) in the Clinical Neurophysiology Laboratory (2001 to present) Psychiatry • Preceptorships of psychiatry residents in Neurology Inpatient Ward and Outpatient Clinics Surgery • Lectures to Division of Neurosurgery on nerve and muscle disease and electrodiagnosis of neuromuscular disorders • Preceptorships of neurosurgical residents on neurology during attending rotation Obstetrics & Gynecology • Lectures to Urogynecology Section of the Department of Obstetrics & Gynecology on anatomy and neurological disorders of voiding and the electrodiagnosis of neuro-urological disorders (twice yearly, 2000 to present) • Preceptorships of Urogynecology Fellows in EMG Laboratory (2000 to present)

NURSING • Participation in Critical Care Nursing course (ICU, Recovery Room), neuromuscular disorders (various times and topics) • Participation in Neurology Inservice Nurse training programs (various times) • Occasional lectures to graduate and undergraduate students in School of Nursing; nursing units in North Carolina Memorial Hospital

COMMUNITY & STATE Area Health Educational Council (A.H.E.C.) (varied activities since 1979) • Lectures to various medical and allied health groups on a variety of neurologic topics • Participation in the University of North Carolina "Internal Medicine" lecture series

North Carolina State University School of Veterinary Medicine, Department of Neurology • Preceptorships of veterinary neurology residents in the EMG Laboratory

OTHER • Organization of and participation in various workshops for the Muscular Dystrophy Association for physicians, allied health personnel and patient groups. • Organization of the Muscular Dystrophy Association Mid-Atlantic Regional Directors' Conference, Chapel Hill, NC, March, 1981. • Organization of the International Single Fiber EMG Course and Symposium, Durham, NC, April, 1983. • Organization of the International Single Fiber EMG Course, Chapel Hill, NC, May, 1987. • Organization of the Symposium on Immune Mechanisms & Therapeutic Strategies in Neurological Diseases, Chapel Hill, NC, July 21, 1989. • Member & Course Designer, Educational Council, Neurology for the Non-Neurologist, Medical Education Resources, Inc., Littleton, CO, 1991. • Organization of the Educational Session for the 1993 North Carolina Medical Society (Neurology Section) Meeting and the North Carolina Neurological Society Meeting, Charlotte, NC, Topics of Therapeutic Chemodenervation. November 6, 1993. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 13

• Session Chair, Plenary Session, Therapeutic Chemodenervation for Movement Disorders: A Rationale Approach, 44th Annual Scientific Meeting of the American Association of Electrodiagnostic Medicine, San Diego, September 19, 1997. • Session Chair, Scientific Session of the National Myasthenia Gravis Foundation Annual Meeting, Montreal, October 17, 1998. • Session Chair, Scientific Session of the National Myasthenia Gravis Foundation Annual Meeting, Seattle, October 9, 1999. • Session Co-Chair, Session on Neuromuscular Junction and Muscle Disorders of the 62nd Annual Meeting of the American Academy of Neurology, Toronto, Ontario, Canada, April 13, 2010

NEUROMUSCULAR/EMG FELLOWS (Post-Doctoral) Current Position • Eric T. Lee, D.O. 2013 — 2014 private practice in Grants Pass, OR • Tania Beltran Papsdorf, M.D. 2012 — 2013 private practice in Springfield, MO • Michael Lui, M.D. 2010 — 2012 private practice in Honolulu, Hawaii • Victoria K. Nwosu, M.D. 2009 — 2010 private practice in Fort Worth, TX • Ratna Bhavaraju-Sanka, M.D. 2007 — 2010 Assistant Professor, Dept. Neurology, University of Texas, San Antonio, TX • H. Alexander Krob, M.D. 2006 — 2007 private practice in Portland, OR • Karen Bontia, M.D. 2005 — 2006 private practice in Irving, TX • Kaditam Reddy, M.D. 2004 — 2005 private practice in Thousand Oaks, CA • Cecily F. Cole, M.D. 2003 — 2004 private practice in Jonesboro, GA • Ajmal Gilani, M.D. 2002 — 2003 private practice in Clayton, NC • Yu Zhu, M.D., Ph.D. 2001 — 2002 private practice in Tacoma, WA • Cristina Go, M.D. 2000 — 2001 Assistant Professor, Department of Pediatrics, Division of Child Neurology, University of Toronto, The Hospital for Sick Children, Toronto, Canada • Urvi Desai, M.D. 1999 — 2000 Department of Neurology, Carolinas Healthcare System, Charlotte, NC • Mohsin K. Ansari, M.D. 1998 — 1999 private practice in Roseville CA • Kristin K. Adams, M.D. 1997 — 1998 private practice in Williamsport, PA • William Gaya, M.D. 1996 — 1997 private practice in Ocala, FL • Christopher J. Scherer, M.D. 1995 — 1996 private practice in Charlottesville, VA • Henry Tellez, M.D. 1995 — 1996 private practice in Asheboro, NC • Paul Schmidt, M.D. 1994 — 1995 private practice in Port St. Lucie, FL • Nalini Samuel, M.D. 1994 — 1995 private practice in Fort Gratiot, MI • Jonathan M. Richman, M.D. 1993 — 1994 private practice in Pinehurst, NC • Karyn H. (Pollak) Karlin, M.D. 1993 — 1994 private practice in Chicago, IL • Allan C. Weiss, M.D. 1992 — 1994 private practice in St. Petersburg, FL • Laura K. Jozewicz, M.D. 1992 — 1993 private practice in Raleigh, NC • M. Kathleen Donovan, M.D., Ph.D. 1990 — 1992 Assistant Professor, Mayo Clinic, Jacksonville, FL • George A. Petroff, M.D. 1990 — 1991 private practice in Gastonia, NC (deceased) • Margit E. Royal, M.D. 1989 — 1990 private practice in Wilmington, NC Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 14

(retired) • Jose A. Canedo, M.D. 1988 — 1989 private practice in Columbus, GA • Clyde R. Snyder, M.D. 1988 — 1989 private practice in Hagerstown, MD • David C. Morris, M.D. 1987 — 1988 private practice in Mount Vernon, WA • Thomas G. Braun, M.D. 1986 — 1987 Associate Professor (emeritus), UNC- Chapel Hill, Chapel Hill, NC (retired) • Donald J. Solomon, M.D. 1985 — 1986 private practice in Whiteville, NC • David A. Kolb, M.D. 1984 — 1985 private practice in Beverley, MA (retired)

OTHER MENTORSHIP • Katherine Ruzhansky, M.D., MS, 2017 Single Fiber EMG & Myasthenia Gravis mentorship, current position, Assistant Professor, Department of Neurology, Medical University of South Carolina, Charleston, SC. • Melissa J. Lewis, V.D.M., 2016 Electrodiagnostic techniques in the animal • Mihaela V. Georgieva, 2014 — 2016 Pre-doctoral student, Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC. • Zheng (Jane) Fan, M.D., 2007 — 2009 Muscular Dystrophy Association (MDA) Clinical Research Training Grants (CRTG); current position, Assistant Professor, Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC. • Zheng (Jane) Fan, M.D., 2007 — 2009 NIH K30 Clinical Research Curriculum Award (CRCA) ; current position, Assistant Professor, Department of Neurology, Division of Child Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC. • Sameh M. Said, M.D., 1995 — 1996 EMG mentorship; current position, Professor of Neurology, Neuropsychiatry Department, Alexandria University, Egypt. • Li-Ying Cui, M.D., 1992 — 1993 Neuromuscular Research Fellow; current position, Director Chief Physician (Chair) and Professor, Department of Neurology, Peking Union Medical Center, Beijing, China.

VISITING PROFESSORSHIPS • Visiting Professor, University of Vermont School of Medicine, Department of Neurology Neuroscience Grand Rounds, Burlington, VT, October 1983. • Visiting Professor, University of South Alabama, Department of Neurology Grand Rounds, Mobile, AL, June 1988. • Visiting Professor, Medical University of South Carolina, Department of Neurology Grand Rounds, Charleston, SC, September 1988. • Visiting Professor, Emory University, Department of Neurology Grand Rounds and Basic Science Research Seminar, Atlanta, GA, October 1988. • Visiting Professor, Robert Wood Johnson School of Medicine, Department of Neurology Grand Rounds, New Brunswick, NJ, May 1994. • Visiting Professor, University of South Carolina, Columbia, Department of Internal Medicine Grand Rounds & Teleconference, Columbia, SC, June 1995. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 15

• Visiting Professor, University of South Carolina, Columbia, Department of Neurology Grand Rounds, Columbia, SC, June 1995. • Visiting Professor, University of South Carolina, Columbia, Department of Neurology Grand Rounds, Columbia, SC, September 1996. • TR Johns Memorial Visiting Professor, Department of Neurology, University of Virginia, Charlottesville, VA, March 1997. • Visiting Professor, University of Alberta, Edmonton, Alberta, Canada, September 27, 2013. • Visiting Professor, University of Vermont School of Medicine, Department of Neuroscience Grand Rounds, Burlington, VT, February 27, 2015. • Visiting Professor, University of Washington, Department of Neurology Grand Rounds, Resident/Fellow EMG Conference, Seattle, WA, March 12, 2015. • Hartwell G. Thompson Visiting Professor, University of Connecticut, Department of Neurology Resident Graduation Address, Grand Rounds, Storrs, CT, May 20-21, 2015. • Visiting Professor, Duke University School of Medicine, Department of Neurology Grand Rounds, Durham, NC, May 27, 2015.

INVITED LECTURES/COURSES • Lecturer at Muscular Dystrophy Association Region 5 Youth Conference, Virginia Beach, VA, 1980 • Lecturer at Ciba-Geigy Neurology Review Course, Durham, NC, September 23-25, 1989. • Lecturer at Ciba-Geigy Neurology Review Course, San Antonio, TX, October 14-16, 1989. • Lecturer at Ciba-Geigy Neurology Review Course, Baltimore, MD, October 28-30, 1989. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, February 9-11, 1990. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, March 17-19, 1990. • Lecturer at Ciba-Geigy Neurology Review Course, Kansas City, MO, May 19-21, 1990. • Lecturer at Ciba-Geigy Neurology Review Course, Tarrytown, NY, September 8-10, 1990. • Lecturer at Ciba-Geigy Neurology Review Course, Durham, NC, October 6-8, 1990. • Lecturer at Ciba-Geigy Neurology Review Course, Orlando, FL, February 16-18, 1991. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, March 9-11, 1991. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, March 16-18, 1991. • Lecturer at Ciba-Geigy Neurology Review Course, Baltimore, MD, October 12-14, 1991. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, February 1-3, 1992. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, February 15-17, 1992. • Lecturer at Ciba-Geigy Neurology Review Course, Atlanta, GA, March 7-9, 1992. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Vail, CO, August 12-14, 1992. • Lecturer at Ciba-Geigy Neurology Review Course, Tarrytown, NY, October 10-12, 1992. • Lecturer at Ciba-Geigy Neurology Review Course, Dallas, TX, October 30-November 1, 1992. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, February 13-15, 1993. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, March 6-8, 1993. • Invited speaker at the 1993 National Myasthenia Gravis Foundation Nurses Workshop, Research Triangle Park, NC, Myasthenia Gravis, April 1, 1993. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Napa Valley, CA, August 13-15, 1993. • Lecturer at Ciba-Geigy Neurology Review Course, Atlanta, GA, October 30-November 1, 1993. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 16

• Lecturer at North Carolina Medical Society (Neurology Section) Meeting and the North Carolina Neurological Society Meeting, Charlotte, NC, Therapeutic Chemodenervation. November 6, 1993. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Breckenridge, CO, February 18-20, 1994. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, February 20-21, 1994. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, March 5-7, 1994. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Lake George, NY, August 19-21, 1994. • Lecturer at Ciba-Geigy Neurology Review Course, Newark, NJ, September 9-11, 1994. • Lecturer/Course Faculty at Lloyd Noland Hospital Current Clinical Internal Medicine Seminar, Orlando, FL, several topics, October 16-19, 1994. • Lecturer at Ciba-Geigy Neurology Review Course, Los Angeles, CA, February 19-21, 1995. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Edgartown, Martha's Vineyard, August 11-13, 1995. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, September 9-11, 1995. • Lecturer at Ciba-Geigy Neurology Review Course, Dallas, TX, October 7-9, 1995. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Nassau, Bahamas, February 15-17, 1996. • Lecturer at Ciba-Geigy Neurology Review Course, Boston, MA, September 7-9, 1996. • Lecturer at Ciba-Geigy Neurology Review Course, Atlanta, GA, September 28-30, 1996. • TR Johns Lectureship at The University of Virginia, Department of Neurology Grand Rounds, Immunological Mechanisms of Myasthenia Gravis, Charlottesville, VA, March 1997. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Lake Louise, Alberta, Canada, July 24-26, 1997. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 6-8, 1997. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, September 13-15, 1997. • Lecturer at North Carolina Chapter of the ALS Foundation, Research Triangle Park, NC, ALS, A Research Update, November 16, 1997 • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Las Vegas, NV, March 19-21, 1998. • Lecturer at Triad Neurological Society, Winston-Salem, NC, Intravenous immunoglobulin in the treatment of neuromuscular disorders, March 25, 1998. • Lecturer at Georgia Chapter of the Myasthenia Gravis Foundation, Atlanta, GA, Myasthenia Gravis 1998, May 23, 1998. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 11-13, 1998. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Bermuda, September 23-25, 1998. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, October 2-4, 1998. • Lecturer at National Myasthenia Gravis Foundation of American, Atlanta, Myasthenia Gravis 101: A Primer for the Myasthenic Patient, April 23, 1999. • Lecturer at IVIg Advisory Meeting, Palm Springs, CA, Myasthenia Gravis, April 30-May 2, 1999. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 17

• Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Santa Fe, July 29-31, 1999. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Los Angeles, CA, August 13-15, 1999. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 4-6, 1999. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, October 1-3 1999. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Cayman Islands, June 22-24, 2000. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 9-11, 2000. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, September 23-25, 2000. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, St. Lucia, BVI, October 19-21, 2000. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Atlanta, GA, October 27-29, 2000. • Lecturer/Course Faculty at Lloyd Noland Hospital Current Clinical Internal Medicine Seminar, Orlando, FL, several topics, March 11-13, 2001. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, April 20-22, 2001. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Monterey, CA, August 3-5, 2001. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 7-9, 2001. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Washington, DC, October 18-20, 2001. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, October 26-28, 2001. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Ft. Lauderdale, FL, November 2-3, 2001. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Niagara Falls, Ontario, August 8-10, 2002. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, August 23-25, 2002. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Boston, MA, September 13-15, 2002. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, September 23-25, 2002. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, San Francisco, CA, June 20-22, 2003. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Orlando, FL, August 1-3, 2003. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, September 19-21, 2003. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 18

• Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Denver, CO, October 10-12, 2003. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Framingham, MA, October 18-20, 2003. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, November 21-23, 2003. • Lecturer at North Carolina Myasthenia Gravis Foundation Meeting, Greenville, NC, Myasthenia Gravis; the New Frontier, March 6, 2004. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, St. Johns, Virgin Islands, April 1-3, 2004. • Lecturer at National Myasthenia Gravis Foundation Meeting, Minneapolis, MN, Myasthenia Gravis; Medical / Scientific Advisory Update, May 6, 2004. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Yosemite, CA, July 9-11, 2004. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Banff, Alberta, Canada, August 5-7, 2004. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, August 27-29, 2004. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, September 17-19, 2004. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Framingham, MA, October 8-10, 2004. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Asheville, NC, May 13-15, 2005. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Cape Cod, MA, July 15-17, 2005. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Chicago, IL, September 9-11, 2005. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, October 7-9, 2005. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Framingham, MA, October 22-24, 2005. • Lecturer at Annual Meeting of the Massachusetts-New Hampshire Myasthenia Gravis Foundation Chapter, Myasthenia Gravis: The New Frontier, Framingham, MA, October 30, 2005. • Lecturer at Aspreva Connect Dinner Seminar on Myasthenia Gravis, Understanding Myasthenia Gravis, Greensboro, NC, November 1, 2005. • Lecturer at Medical Education Resources Course Internal Medicine Update, Las Vegas, NV, March 4-6, 2006. • Lecturer at Medical Education Resources Course Internal Medicine Update, New York, NY, June 9-11, 2006. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Monterey, CA, August 11-13, 2006. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Houston, TX, September 22-24, 2006. • Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Framingham, MA, October 28-30, 2006. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 19

• Lecturer at Novartis Neurology Review Course (previously known as the Ciba-Geigy Neurology Review Course), Atlanta, GA, November 11-13, 2006. • Lecturer at Annual Meeting of the Myasthenia Gravis Association of Barbados, Myasthenia Gravis 101: Past, Present and Future. Bridgetown, Barbados, May 30, 2007. • Lecturer at Medical Education Resources Course Internal Medicine Update, Mackinac Island MI, July 13-15, 2007. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, St. Johns, Virgin Islands, November 1-3, 2007. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, San Francisco, CA, June 6-8, 2008. • Lecturer at US Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis. New York, June 21, 2008. • Lecturer at Medical Education Resources Course Internal Medicine Update, Jackson Hole, WY, July 25-27, 2008. • Lecturer at Medical Education Resources Course Neurology for the Non-Neurologist, Philadelphia PA, November 21-23, 2008. • Lecturer at Duke University Advanced EMG and EMG-Guided Chemodenervation Course, Durham, NC. Mechanisms and Quality Control in Repetitive Nerve Stimulation. March 14, 2009. • Lecturer at UK Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis. London, January 15, 2010. • Lecturer at Medical Education Resources Course Internal Medicine Update, Scottsdale AZ, March 12-15, 2010. • Lecturer at Triangle Global Health Consortium One Health Collaborative of North Carolina (One Health Intellectual Exchange) Translational Lessons Learned from a Canine Model of Duchenne Muscular Dystrophy. NC Biotechnology Center, RTP, May 17, 2011. • Lecturer at the 12th International Conference on Myasthenia Gravis and Related Disorders. Randomized, double-blind, placebo-controlled, crossover, multicenter, phase II study of eculizumab in patients with refractory generalized myasthenia gravis. New York, NY, May 2012. • Lecturer at University of Alberta Department of Neurology Neuromuscular Conference, Translational Models of Muscular Dystrophy, Edmonton, Alberta, Canada, September 27, 2013. • Lecturer at the 4th Annual Myasthenia Gravis Patient Education Day, University of Alberta, Edmonton, Myasthenia Gravis, Random Musings, Alberta, Canada, September 28, 2013. • Lecturer at US & South America Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis and Phase 2Eculizumab Results in MG. Atlanta, January 30, 2014. • Lecturer at Japanese Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis and Phase 2Eculizumab Results in MG. (presentation by video conferencing) Tokyo, Japan, March 8, 2014. • Lecturer at European & Australian Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis and Phase 2Eculizumab Results in MG. Budapest, Hungary, March 14, 2014. • Lecturer at Duke University 12th Advanced EMG and EMG-Guided Chemodenervation Workshop, Mechanisms and Quality Control Issues in Repetitive Nerve Stimulation, Durham, NC, April 12, 2014. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 20

• Lecturer at Simposio de Neuroinmunologia, Miastenia Gravis Refractaria: Nuevos Enfoques Terapeuticos. FLENI, Sede Belgrano, Buenos Aires, Argentina, August 1-2, 2014. • Lecturer at Inaugural UNC Neuromuscular Symposium, An Approach to the Patient with Neuromuscular Disease, Chapel Hill, NC, February 7, 2015. • Lecturer at Inaugural UNC Neuromuscular Symposium, An Approach to the Patient with Disease of the Neuromuscular Junction, Chapel Hill, NC, February 7, 2015. • Lecturer at Duke University 12th Advanced EMG and EMG-Guided Chemodenervation Workshop, Mechanisms and Quality Control Issues in Repetitive Nerve Stimulation, Durham, NC, March 8, 2015. • Lecturer at University of Vermont School of Medicine, Department of Neuroscience Grand Rounds, Translational Models of Muscular Dystrophy, Burlington, VT, February 27, 2015. • Lecturer at University of Washington, Department of Neurology Grand Rounds, The role of complement in Myasthenia Gravis, Seattle, WA, March 12, 2015. • Lecturer at University of Washington, Department of Neurology Resident/Fellow EMG Conference, Clinical Case Correlations in the EMG Laboratory, Seattle, WA, March 12, 2015. • Lecturer at Quintiles European Eculizumab CRA meeting, Myasthenia Gravis – Clinical Overview. Barcelona, April 13, 2015. • Lecturer at European Eculizumab Investigator meeting, The role of complement in Myasthenia Gravis. Barcelona, April 14, 2015. • Lecturer at University of Connecticut School of Medicine, Department of Neurology Graduation Dinner, 8 Rules for Neurological Success, Storrs, CT, May 20, 2015. • Hartwell G. Thompson Lectureship at University of Connecticut School of Medicine, Department of Neurology Grand Rounds, Translational Models of Muscular Dystrophy, Storrs, CT, May 21, 2015. • Lecturer at Duke University School of Medicine, Department of Neurology Grand Rounds, Translational Models of Muscular Dystrophy, Durham, NC, May 27, 2015. • 5th Annual Mathilda Karel Spak Lecturer at University of California – Irvine, Department of Neurology Neuromuscular Colloquium, Autoimmune Disorders of Neuromuscular Transmission – Where Do We Stand on the Clinical Trials Landscape?, Huntington Beach, CA, May 29, 2015. • Lecturer at Industry Forum, Unmet Needs in Myasthenia Gravis, The role of complement in Myasthenia Gravis. Presented at the at the 62nd Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Honolulu, Hawaii, October 30, 2015. • Lecturer at Satellite Symposium of the 2nd Congress of the European Academy of Neurology, The role of complement in myasthenia gravis. Copenhagen, Denmark, May 29, 2016. • Lecturer at 14th International Congress on Neuromuscular Diseases, Plenary Hot Topics Session, REGAIN: a randomized, double-blind, placebo-controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis, Toronto, Canada July 7, 2016. • Lecturer at the Myasthenia Gravis Annual Scientific Session, REGAIN: a randomized, double- blind, placebo-controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis, New Orleans, LA, September 14, 2016. • Lecturer at the 2016 Muscle Study Group meeting, REGAIN: a randomized, double-blind, placebo-controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis, Snowbird, UT; September 25, 2016. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 21

• Lecturer at the Argenx Investigatory meeting Myasthenia Gravis; An Overview. Amsterdam, Netherlands, December 3, 2016. • Lecturer at the Argenx Pharmaceuticals Science Seminar. Therapeutic Strategies in Myasthenia Gravis; 2016 and Beyond. Ghent, Belgium, December 5, 2016. • Lecturer at the Ra Pharmaceuticals Myasthenia Gravis Advisory Board. Complement in the Treatment of Myasthenia Gravis. New York, NY, January 28, 2017. • Lecturer at the 2016 Annual South Carolina Neurological Association meeting, Myasthenia Gravis 2017 and Beyond. Asheville, NC, March 24-25, 2017.

COURSE FACULTY • Lecturer at Muscular Dystrophy Association Neuromuscular Disease Symposium, Chapel Hill, NC, March 1979. • Lecturer at the Muscular Dystrophy Association Mid-Atlantic Regional Directors' Conference, Chapel Hill, NC, March1981. • Lecturer at Emory University, Department of Neurology Post-graduate Course on Myasthenia Gravis. Atlanta, GA, November 1983. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Single Fiber Electromyography, 1984. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Single Fiber Electromyography, 1985. • Lecturer/Course Faculty at the International Single Fiber EMG Course, Toronto, Canada, June 1985. • Lecturer at the VI International Congress on Neuromuscular Diseases, Los Angeles, CA, July 1986. • Lecturer/Course Faculty at Duke University Workshop on Advanced Electromyographic Techniques, Keystone, CO, February 1990. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Single Fiber Electromyography, Miami, FL, May 1990. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Courses on Electrodiagnostic Problems, Chicago, IL, September 1990. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Repetitive Nerve Stimulation, Boston, MA, April 1991. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Courses on Electrodiagnostic Problems, Vancouver, British Columbia, September 1991. • Lecturer/Course Faculty at Duke University Workshop on Advanced Electromyographic Techniques, Park City, UT, March 1992. • Lecturer/Course Faculty at Allegheny General Hospital, Medical College of Pennsylvania on Current Progress in Neuroimmunology, Pittsburgh, PA, November 1992. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Therapy of Neurology, New York, NY, May 1993. • Lecturer/Course Faculty at Case Western Reserve University School of Medicine, Symposium on Myasthenia Gravis, Cleveland, OH, September 1994. • Lecturer/Course Faculty at Annual American Academy of Neurology Course on Myasthenia Gravis and Myasthenic Syndromes, Seattle, WA, May 1995. • Lecturer at Duke University, Division of Neurology Neuromuscular Conference, Durham, NC, June 1995. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 22

• Lecturer/Course Faculty at Allegheny General Hospital, Medical College of Pennsylvania on Current Progress in Neuroimmunology, Pittsburgh, PA, July 1995. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Workshop on Single Fiber EMG, Montreal, Canada, September 1995. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Special Interest Group on Computer Technology and the Internet - eMAIL Applications, Montreal, Canada, September 1995. • Lecturer/Course Faculty at Duke University Course on Selected Topics in EMG, Durham, NC, November 1995. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Workshop on Single Fiber EMG, Minneapolis, MN, October 1996. • Lecturer/Course Faculty at Annual American Association of Electrodiagnostic Medicine Special Interest Group on Single Fiber EMG, Minneapolis, MN, October 1996. • Lecturer/Course Faculty at 44th Annual American Association of Electrodiagnostic Medicine Special Interest Group on Single Fiber EMG, San Diego, CA, September 1997. • Lecturer/Course Faculty at Annual American Academy of Neurology Courses on Autoimmune Myasthenia (Myasthenia Gravis) & Myasthenic Syndrome, Minneapolis, MN, May, 1998. • Lecturer/Course Faculty at 45th Annual American Association of Electrodiagnostic Medicine Workshop on Advanced Single Fiber EMG, Orlando, FL, October 1998. • Lecturer/Course Faculty at New York University Advances in the Pathogenesis, Diagnosis and Treatment of Myasthenia Gravis, New York, NY May 2000. • Lecturer/Course Faculty at 47th Annual American Association of Electrodiagnostic Medicine Workshop on Repetitive Nerve Stimulation, Philadelphia, PA, September 2000. • Lecturer/Course Faculty at 48th Annual American Association of Electrodiagnostic Medicine Workshop on Repetitive Nerve Stimulation, Albuquerque, NM, October 2001. • Lecturer/Course Faculty at 48th Annual American Association of Electrodiagnostic Medicine Workshop on Single Fiber EMG, Albuquerque, NM, October 2001. • Lecturer/Course Faculty at 49th Annual American Association of Electrodiagnostic Medicine Workshop on Repetitive Nerve Stimulation, Toronto, Canada October 2002. • Course Faculty at Duke University Workshop on Advanced EMG and EMG-Guided Chemodenervation, Durham, NC, February 14-16, 2003. • Lecturer at American College of Veterinary Internal Medicine (Neurology), Quantitative Electrodiagnostic Testing. An Aid to the EMG Examination, Charlotte, NC, June 6, 2003. • Lecturer at North Carolina State University College of Veterinary Medicine Course in Veterinary Neuroscience & Advanced Clinical Neurology/Neurosurgery, Quantitative Electrodiagnostic Testing. An Aid to the EMG Examination, Raleigh, NC, July 31, 2003. • Lecturer/Course Faculty at 50th Annual American Association of Electrodiagnostic Medicine Workshop on Repetitive Nerve Stimulation, San Francisco, CA September 2003. • Course Faculty at Duke University Workshop on Advanced EMG and EMG-Guided Chemodenervation, Durham, NC, February 6-8, 2004. • Lecturer/Course Faculty at Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, San Francisco, CA April 2004. • Lecturer/Course Faculty at 51st Annual American Association of Electrodiagnostic Medicine Workshop on Repetitive Nerve Stimulation, San Francisco, CA November 2004. • Course Faculty at Duke University Workshop on Advanced EMG and EMG-Guided Chemodenervation, Durham, NC, January 28-30, 2005. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 23

• Lecturer/Course Faculty at Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, San Miami, FL April 2005. • Lecturer/Course Faculty at 52nd Annual American Association of Electrodiagnostic & Neuromuscular Medicine Workshop on Repetitive Nerve Stimulation, Monterey, CA September 2005. • Lecturer/Course Faculty at Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, San Diego, CA April 2006. • Lecturer at North Carolina State University College of Veterinary Medicine Course in Veterinary Neuroscience & Advanced Clinical Neurology/Neurosurgery, Origins of the EMG Signal and the Utility of Quantitative Electrodiagnostic Testing, Raleigh, NC, July 27, 2006. • Lecturer/Course Faculty at 53rd Annual American Association of Electrodiagnostic & Neuromuscular Medicine Workshop on Basic Single Fiber EMG, Washington, DC, October 2006. • Course Faculty at Duke University Workshop on Advanced EMG and EMG-Guided Chemodenervation, Durham, NC, March 23-25, 2007. • Lecturer/Course Faculty at Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, Boston, MA May 2007. • Lecturer/Course Faculty at 54th Annual American Association of Electrodiagnostic & Neuromuscular Medicine Workshop on Repetitive Nerve Stimulation, Phoenix, AZ October 2007. • Lecturer/Course Faculty at 54th Annual American Association of Electrodiagnostic & Neuromuscular Medicine Expert Round Table on The Use of IVIg in the Treatment of Neuromuscular Disorders, Phoenix, AZ October 2007. • Course Faculty at Duke University Workshop on Advanced EMG and EMG-Guided Chemodenervation, Durham, NC, March 7-9, 2008. • Lecturer/Course Faculty at Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, Chicago, IL April 2008. • Lecturer/Course Faculty at 55th Annual American Association of Electrodiagnostic & Neuromuscular Medicine Workshop on Repetitive Nerve Stimulation, Phoenix, AZ September 17, 2008. • Lecturer/Course Faculty at 55th Annual American Association of Electrodiagnostic & Neuromuscular Medicine Seminar, Medication Toxicity and Neuromuscular Disease on Medication Toxicity and Disorders of Neuromuscular Transmission, September 17, 2008. • Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 13-15, 2009. • Lecturer/Course Faculty at 56th Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, Seattle, WA May 2009. • Lecturer at the Xth Quantitative EMG Conference, Physiological and Molecular Aspects of the Neuromuscular Junction and Synaptic Transmission. Venice, Italy May 2009. • Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 5-7, 2010. • Course Faculty at the 5th Annual UNC PM&R State of the Art Conference, A Review of Neurography, Principles and Techniques, Chapel Hill, NC, March 26, 2010. • Course Faculty at the 5th Annual UNC PM&R State of the Art Conference, A Review of Electromyography, Principles and Techniques, Chapel Hill, NC, March 26, 2010. • Lecturer/Course Faculty at 57th Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, Toronto Canada, April 12, 2010. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 24

• Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 4-6, 2011. • Course Faculty at Duke University, Workshop, Repetitive Nerve Stimulation at the 10th Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 2-4, 2012. • Lecturer/Course Faculty at 59th Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, New Orleans, April 26, 2012. • Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the 11th Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 1-3, 2013. • Lecturer/Course Faculty at 60th Annual American Academy of Neurology Advanced EMG Skills Workshop on Repetitive Nerve Stimulation, San Diego, CA, March 19, 2013. • Visiting Professor, Translational Models of Muscular Dystrophy and EMG Cases, Department of Neurology, University of Alberta, Edmonton, Alberta, Canada, September 27, 2013. • Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the 12th Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, April 11-13, 2014. • Course Faculty at Duke University Workshop, Repetitive Nerve Stimulation at the 12th Advanced EMG and EMG-Guided Chemodenervation Workshop, Durham, NC, March 6-8, 2015. • Lecturer/Course Faculty at the Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Immunotherapy in Neuromuscular Disease, New Orleans, September 14-17, 2016.

RESEARCH ACTIVITIES • Research activity is centered in the immunology and physiology of synaptic transmission in normal and its associated disease states. Studies include or have included:  Sensitivity of Single Fiber EMG (SFEMG) in facial, periocular and limb muscles in patients with Myasthenia Gravis  A quantitative comparison of the variation in neuromuscular ‘safety factor’  The electrophysiological characteristics of neuromuscular transmission in intercostal muscle biopsies from patients with myasthenia gravis  Quantitative electromyography in neuromuscular disorders  T-cell and B-cell function in myasthenia gravis • Research activity is centered in clinical neuromuscular disease, Myasthenia Gravis and Duchenne Muscular Dystrophy. Studies include or have included:  The safety and efficacy of various drugs in the treatment of myasthenia gravis; i.e. eculizumab, mycophenolate mofetil, intravenous gamma globulin and 3,4- diaminopyridine, cyclosporine A  Safety and feasibility of transvenous limb perfusion with normal saline in human muscular dystrophy  Longitudinal physiological assessment of muscle membrane function in the golden retriever model of muscular dystrophy

Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 25

PUBLICATIONS 1. Howard JF, Sanders DB, Johns TR: The role of plasma exchange in the treatment of myasthenia gravis. Proceedings of the Haemonetics Research Institute Advanced Component Seminar, June, 1978. 2. Sanders DB, Howard JF, Johns TR: Single fiber electromyography in myasthenia gravis. Neurology, 29:68-76, 1979. PMID: 218146. 3. Sanders DB, Howard JF: The role of plasmapheresis (plasma exchange) in the treatment of myasthenia gravis. Syllabus, Special Course in Neuromuscular Disorders. 31st Annual Meeting of the American Academy of Neurology, Chicago, April 1979. 4. Sanders DB, Howard JF, Johns TR: The immunopathology and immunotherapy of myasthenia gravis. Syllabus, Special Course in Immunology-Virology of the Nervous System. 31st Annual Meeting of the American Academy of Neurology Chicago, April 1979. 5. Howard JF, Sanders DB: Passive transfer of human myasthenia gravis to rats: l. Electrophysiology of the developing neuromuscular block. Neurology, 30:760-764, 1980. PMID: 7190241. 6. Sanders DB, Kim YI, Howard JF, Goetsch CA: Eaton-Lambert syndrome: A clinical and electrophysiological study of a patient treated with 4-aminopyridine. Journal of Neurology, Neurosurgery, and Psychiatry, 43:978-985, 1980. PMID: 6255102. 7. Sanders DB, Kim YI, Howard JF, Johns TR, Muller WH: Intercostal muscle biopsy studies in myasthenia gravis: Clinical correlations and the direct effects of drugs and myasthenic serum. In Myasthenia Gravis: Pathophysiology and Management, edit. D. Grob, Annals of the New York Academy of Sciences 377:544-566, 1981. PMID: 6280565. 8. Sanders DB, Howard JF, Johns TR: Plasma exchange in the treatment of myasthenia gravis. In Disorders of the Motor Unit, edit. D.L. Schotland, John Wiley and Sons, Inc., New York, Chapter 25:299-304, 1982. 9. Howard JF: Nonsteroidal immunosuppressive therapy for myasthenia gravis. Seminars in Neurology, 2:265-269, 1982. 10. Howard JF: The treatment of myasthenia gravis with plasma exchange. Seminars in Neurology, 2:273-279, 1982. 11. Quint SR, Howard JF, Antoni L: On-line analysis of neuromuscular bioelectric potentials. Computer Programs in Biomedicine, 16:3-12, 1983. PMID: 6851497. 12. Christenson RH, Behlmer P, Howard JF, Winfield JB, Silverman LM: Interpretation of cerebrospinal fluid proteins in various neurologic diseases. Clinical Chemistry, 29:1028-1030, 1983. PMID: 6851088. 13. Howard JF, Sanders DB: The treatment of patients with myasthenia gravis. Neurology and Neurosurgery, 4(27):1-8, 1983. 14. Sargent D, Mease E, Howard JF: Cytomegalovirus pneumonia presenting as a lobar infiltrate. North Carolina Medical Journal, 46(4):245-246, 1985. PMID: 3857473. 15. Quint SR, Greenwood RS, Howard JF, Gomez VJ: Automated data-acquisition and analysis of neural evoked potentials. Computer Methods and Programs in Biomedicine, 20:35-44, 1985. PMID: 3849376. 16. Howard JF, Miller RG, Olarte MR, Sanders DB: Myasthenia gravis - A manual for the physician. The Myasthenia Gravis Foundation, New York, pp. 1-20, 1985. 17. Sanders DB, Howard JF: Single-fiber electromyography in myasthenia gravis. Muscle and Nerve, 9:809-819, 1986. PMID: 3785290. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 26

18. Howard JF: Intravenous immunoglobulin in myasthenia gravis. Immunopathology and Immunotherapy, Letter, 3:6-7, 1988. 19. Cook L, Howard JF, Folds JD: Immediate effects of intravenous IgG administration on peripheral blood B- and T-cells and PMNs in patients with myasthenia gravis. Journal of Clinical Immunology, 8:23-31, 1988. PMID: 2966808. 20. Sanders DB, Howard JF: Thymoma without myasthenia gravis: single-fiber EMG studies. Journal of Neurology, Neurosurgery, and Psychiatry, 51:160-161, 1988. PMID: 3351526. 21. Massey JM, Sanders DB, Howard JF: The effects of cholinesterase inhibitors on single fiber electromyography in myasthenia gravis. Muscle and Nerve, 12:154-155, 1989. PMID: 2540433. 22. Weig SG, Howard JF, Fry T: Metastatic laryngeal carcinoma as a cause of progressive ophthalmoplegia. Southern Medical Journal, 82:1051-1052, 1989. PMID: 2762889. 23. Cheshire WP, Howard JF, Young J: Cysticercosis: Pandemonium in pigdom. North Carolina Medical Journal, 50:538-540, 1989. PMID: 2594092. 24. Howard JF: Therapeutic apheresis and polymyositis [letter]. Journal of Clinical Apheresis, 5:61, 1990. PMID: 2298717. 25. Protti MP, Manfredi AA, Straub C, Howard JF, Conti-Tronconi BM: CD4+ T cell response to the human acetylcholine receptor α subunit in myasthenia gravis. A study with synthetic peptides. Journal of Immunology, 144:1276-1281, 1990. PMID: 1968078. 26. Protti MP, Manfredi AA, Straub C, X. Wu, Howard JF, Conti-Tronconi BM: Use of synthetic peptides to establish anti-human acetylcholine receptor CD4+ cell lines from myasthenia gravis patients. Journal of Immunology, 144:1711-1720, 1990. PMID: 1968487. 27. Howard JF: Adverse drug effects on neuromuscular transmission. Seminars in Neurology, 10:89- 102, 1990. PMID: 2161128. 28. Sanders DB, Howard JF: Single Fiber EMG. Syllabus, Special Skills Workshop in Electromyography. 42nd Annual Meeting of the American Academy of Neurology, 1990. 29. Howard JF: Electrophysiologic assessment of neuromuscular ptosis. Syllabus, Common Problems in Electrodiagnostic Medicine, American Association of Electrodiagnostic Medicine, 1990. 30. Protti MP, Manfredi AA, Straub C, Howard JF, Conti-Tronconi BM: Immunodominant regions for T-helper sensitization on the human nicotinic receptor α subunit in myasthenia gravis. Proceedings of the National Academy of Sciences USA, 87:7792-7796, 1990. PMID: 2145582; PMCID: PMC54834. 31. Hall CD, Howard JF, Donohue JF: The ventilator support of patients with neuromuscular disorders. Loss, Grief and Care, 4:185-191, 1990. 32. Howard JF: Adverse drug interactions in disorders of neuromuscular transmission. The Journal of Neurological and Orthopaedic Medicine and Surgery, 12:26-34, 1991. 33. Protti MP, Manfredi AA, Wu XD, Moiola L, Howard JF, Conti-Tronconi BM: Myasthenia gravis, T epitopes on the  subunit of human muscle acetylcholine receptor. Journal of Immunology, 146:2253-2261, 1991. PMID: 1706391. 34. Protti MP, Manfredi AA, Straub C, Howard JF, Conti-Tronconi BM: T cells in myasthenia gravis specific for embryonic acetylcholine receptor. Neurology, 41:1809-1814, 1991. PMID: 1682852. 35. Ad Hoc Committee of the AAEM Single Fiber Special Interest Group: Single fiber EMG reference values: a collaborative effort. Muscle and Nerve, 15:151-161, 1992. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 27

36. Manfredi, A.A., Protti MP, Wu XD, Howard JF, Conti-Tronconi BM: CD4+ T-epitope repertoire on the human acetylcholine receptor α subunit in severe myasthenia gravis: A study with synthetic peptides. Neurology, 42:1092-1100, 1992. PMID: 1374548. 37. Protti MP, Manfredi AA, Wu XD, Moiola L, Dalton MW, Howard JF, Conti-Tronconi BM: Myasthenia gravis: CD4+ epitopes on the embryonic  subunit of human muscle acetylcholine receptor. Journal of Clinical Investigation, 90:1558-1567, 1992. PMID: 1383275; PMC443203. 38. Hopkins AL, Howard JF, Wheeler SJ, Kornegay JN: Stimulated single fibre electromyography in normal dogs. Journal of Small Animal Practice, 34:271-276, 1993. 39. Moiola L, Protti MP, Manfredi AA, Yuen M-H, Howard JF, Conti-Tronconi BM: T-helper epitopes on human nicotinic receptor in myasthenia gravis. Annals of the New York Academy of Sciences, 681:198-218, 1993. 40. Sanders DB, Howard JF, Massey JM: 3,4-Diaminopyridine in Lambert-Eaton myasthenic syndrome and myasthenia gravis. Annals of the New York Academy of Sciences, 681:588-592, 1993. PMID: 8357206. 41. Manfredi AA, Protti MP, Dalton MW, Howard JF, Conti-Tronconi BM: T helper cell recognition of muscle acetylcholine receptor in myasthenia gravis. Journal of Clinical Investigation, 92:1055- 1067, 1993. PMID: 7688757; PMC294946. 42. Witsell DL, Weissler MC, Donovan MK, Howard JF, Martinkosky SJ: Measurement of laryngeal resistance in the evaluation of botulinum toxin injection for the treatment of focal laryngeal dystonia. Laryngoscope, 104:8-11, 1994. PMID: 8295461. 43. Moiola L, Karachunski P, Protti MP, Howard JF, Conti-Tronconi BM: Epitopes on the beta subunit of human muscle acetylcholine receptor recognized by CD4+ cells of myasthenia gravis: patients and healthy subjects. Journal of Clinical Investigation, 93:1020-1028, 1994. PMID: 7510715; PMCID: PMC294026. 44. Moiola L, Protti MP, McCormick D, Howard JF, Conti-Tronconi BM: Myasthenia gravis: residues of the α and  subunits of muscle acetylcholine receptor involved in formation of immunodominant CD4+ epitopes. Journal of Immunology. 152:4686-4698, 1994. 45. Howard JF, Sanders DB, Massey JM: The electrodiagnosis of myasthenia gravis and the Lambert- Eaton myasthenic syndrome. Neurologic Clinics, 12:305-330, 1994. PMID: 8041344. PMID: 8041344. 46. Bromberg MB, Scott DM, Ad Hoc Committee of the AAEM Single Fiber Special Interest Group: Single fiber EMG reference values: reformatted in tabular form. Muscle & Nerve 17:820-821, 1994. 47. Andrews PI, Massey JM, Howard JF, Sanders DB: Race, sex and puberty influence onset, severity and outcome of juvenile myasthenia gravis (JMG). Neurology, 44:1208-1214, 1994. PMID: 8035917 48. Yuen M-H, Protti MP, Okita-Diethelm B, Moiola L, Howard JF, Conti-Tronconi BM: Immunoregulatory CD8+ cells recognize antigen activated CD4+ cells in myasthenia gravis patients and in healthy controls. Journal of Immunology 154:1508-1520, 1995. PMID: 7529806. 49. Detterbeck FC, Scott WW, Howard JF, Egan TM, Keagy BA, Starek PJK, Mill MR, Wilcox BR: One hundred consecutive thymectomies. The Annals of Thoracic Surgery 62:242-245, 1996. PMID: 8678650. 50. Cheshire WP, Santos CS, Massey EW, Howard JF: Spinal cord infarction: etiology and outcome. Neurology 47:321-330, 1996. PMID: 8757000. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 28

51. Jaradeh S, D'Cruz O, Howard JF, Haberkamp TJ, Konkol RJ: Möbius syndrome: electrophysiologic studies in seven cases. Muscle Nerve 19:1148-1153, 1996. PMID: 8761272. 52. Cheshire WP, Santos CS, Massey EW, Howard JF: Spinal cord infarction – A reply. Neurology 48:1478, 1997. 53. Sanders DB, Andrews PI, Howard JF, Massey JM: Seronegative myasthenia gravis. Neurology 48(Suppl 5):S40-S45, 1997. 54. Patton L, Howard JF: Myasthenia gravis: Dental treatment considerations. Special Care in Dentistry 17:25-32, 1997. PMID: 9582706. 55. Wang Z-Y, Okita DK, Howard JF, Conti-Fine BM: Th1 epitope repertoire on the α subunit of human muscle acetylcholine receptor in myasthenia gravis. Neurology 48:1643-1653, 1997. PMID: 9191781. 56. Navaneetham D, Penn AS, Howard JF, Conti-Fine BM: Expression of the α7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic thymuses. Cellular and Molecular Biology (Noisy-Le-Grand) 43:433-442, 1997. PMID: 9193799. 57. Raju R., Navaneetham D, Protti MP, Horton RM, Hoppe BL, Howard JF, Conti-Fine BM: TCR Vβ usage by acetylcholine receptor-specific CD4+ T cells in myasthenia gravis. Journal of Autoimmunity 10(2): 203-217, 1997. PMID: 9185882. 58. Wang Z-Y, Okita DK, Howard JF, Conti-Fine BM: T cell recognition of muscle acetylcholine receptor subunits in generalized and ocular myasthenia gravis. Neurology 50:1045-1054, 1998. PMID: 9566393. 59. Finkel AG, Howard JF, Mann JD: Successful treatment of headache related to intravenous immunoglobulin (IVIG) with antimigraine medications: a case report. Headache, 38:317-321, 1998. PMID: 9595875. 60. Conti-Fine BM, Navaneetham D, Karachunski PI, Raju R, Diethelm-Okita B, Okita D, Howard JF, Wang Z-W: T-cell recognition of the acetylcholine receptor in myasthenia gravis. Annals of the New York Academy of Sciences, 841:283-308, 1998. DOI: 10.1111/j.1749-6632.1998.tb10936.x PMID: 9668248. 61. Diethelm-Okita B, Wells G, Kuryatov A, Okita D, Howard JF, Lindstrom J, Conti-Fine BM: Biosynthetic and synthetic AChR sequences to study T cells in myasthenia gravis. Annals of the New York Academy of Sciences, 841:320-323, 1998. DOI: 10.1111/j.1749-6632.1998.tb10937.x 62. Raju, R, Navaneetham D, Protti MP, Horton RM, Hoppe B, Howard JF, Conti-Fine BM: TCR Vβ usage by acetylcholine receptors specific CD4+ T cells in myasthenia gravis. Annals of the New York Academy of Sciences, 841:324-329, 1998. DOI: 10.1111/j.1749-6632.1998.tb10939.x 63. Wang Z-W, Okita DK, Howard JF, Conti-Fine BM: Th1 cells of myasthenia gravis patients recognize multiple epitopes on the muscle acetylcholine receptor  subunit. Annals of the New York Academy of Sciences, 841:329-333, 1998. DOI: 10.1111/j.1749-6632.1998.tb10940.x PMID: 9668252. 64. Wang Z-W, Okita DK, Howard JF, Conti-Fine BM: CD4+ epitope spreading and differential T cell recognition of muscle acetylcholine receptor subunits in myasthenia gravis. Annals of the New York Academy of Sciences, 841:334-337, 1998. DOI: 10.1111/j.1749-6632.1998.tb10941.x PMID: 9668253. 65. Husain AM, Massey JM, Howard JF, Sanders DB: Acetylcholine receptor antibody measurements in acquired myasthenia gravis. Diagnostic sensitivity and predictive value for thymoma. Annals of the New York Academy of Sciences, 841:471-474, 1998. PMID: 9668277. DOI: 10.1111/j.1749- 6632.1998.tb10965.x PMID: 9668277. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 29

66. Wang Z-W, Okita DK, Howard JF, Conti-Fine BM: CD4+ T cell repertoire on the εsubunit of muscle acetylcholine receptor in myasthenia gravis. Journal of Neuroimmunology 91:33-42, 1998. PMID: 9846817. 67. Diethelm-Okita B, Wells GB, Kuryatov A, Okita D, Howard J, Lindstrom JM, Conti-Fine BM: Response of CD4+ T cells from myasthenic patients and healthy subjects of biosynthetic and synthetic sequences of the nicotinic acetylcholine receptor. Journal of Autoimmunity, 11(2):191- 203, 1998. 68. Howard JF: Intravenous immunoglobulin for the treatment of acquired myasthenia gravis. Neurology 51:S30-S36, 1998. 69. Howard JF: Where’s the research? Myasthenia Gravis Foundation Newsletter. 1:5-6, 1998. 70. Navaneetham D, Penn A, Howard JF, Conti-Fine BM: TCR Vβ usage in the thymus and blood of myasthenia gravis patients. Journal of Autoimmunity 11:621-633, 1998. 71. Wang Z-W, Karachunski PI, Howard JF, Conti-Fine BM: Myasthenia in SCID mice grafted with myasthenic patient lymphocytes: Role of CD4+ and CD8+ cells. Neurology 52:484-497, 1999. 72. Howard JF: The myasthenic facies and snarl. Journal of Clinical Neuromuscular Disease 1:214- 215, 2000. 73. Wang Z-W, Diethelm-Okita B, Okita DK, Kaminski HJ, Howard JF, Conti-Fine BM: T cell recognition of muscle acetylcholine receptor in ocular myasthenia gravis. Journal of Neuroimmunology 108:29-39, 2000. 74. Navaneetham D, Penn AS, Howard JF, Conti-Fine BM: Human thymuses express incomplete sets of muscle acetylcholine receptor transcripts that seldom include the δ subunit. Muscle Nerve 24:203-210, 2001. 75. Huang X, Howard JF: Myasthenia gravis and vitiligo: five new cases. Journal of Clinical Neuromuscular Disease 2:173-175, 2001. 76. Latov N, Chaudry V, Koski CL, Lisak RP, Apatoff BR, Hahn AF, Howard JF: Use of intravenous gamma globulins in neuroimmunologic disease. The Journal of Allergy and Clinical Immunology 108:S126-S132, 2001. 77. Mareska MC, Adams KK, Muenzer J, Braun TG, Howard JF: Late onset presentation of glutaric acidemia type II with myopathy. Journal of Clinical Neuromuscular Disease 4:124-128, 2003. 78. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ. Distal symmetrical polyneuropathy: Definition for clinical research. Muscle Nerve 31:113-123, 2005. 79. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ. Distal symmetrical polyneuropathy: Definition for clinical research (Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation). Neurology 64:199-207, 2005. 80. England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ. Distal symmetrical polyneuropathy: a definition for clinical research. A report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Arch Phys Med Rehabil. Jan;86(1):167-74, 2005. 81. Galano HR, Olby N, Howard JF, Shelton D: Myokymia and neuromyotonia in a domestic short- haired cat. Journal of the American Veterinary Association, 15:1608-1612, 2005. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 30

82. Stewart SB, Robertson KR, Johnson KM, Howard JF: The prevalence of depression in myasthenia gravis. Journal of Clinical Neuromuscular Disease 8:111-115, 2007. 83. De Sousa EA, Howard JF: More evidence for the association between statins and myasthenia gravis [editorial]. Muscle and Nerve 38:1085-1086, 2008. 84. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: The evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Muscle Nerve Jan;39(1):106-15, 2009. 85. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: The evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review). Muscle Nerve Jan;39(1):116-25, 2009. 86. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review); Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. PM&R 1(1):5-13, 2009. 87. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence- based review); Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. PM&R 1(1):14-22, 2009. 88. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence- based review); Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. Neurology 72(2):177-184, 2009. 89. England JD, Gronseth GS, Franklin G, Carter GT, Kinsella LJ, Cohen JA, Asbury AK, Szigeti K, Lupski JR, Latov N, Lewis RA, Low PA, Fisher MA, Herrmann DN, Howard JF, Lauria G, Miller RG, Polydefkis M, Sumner AJ: Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review); Report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation Neurology 72(2):185-192, 2009. 90. Donofrio PD, Berger A, Brannagan TH, Bromberg MB, Howard JF, Latov N, Quick A, Tandan R. Consensus statement: The use of intravenous immunoglobulin in the treatment of neuromuscular conditions report of the AANEM Ad Hoc committee. Muscle Nerve 40(5):890- 900, 2009. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 31

91. Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Qiao C, Howard JF, Xiao X: Widespread muscle expression of an AAV-9 human mini-dystrophin construct after intravenous injection in neonatal dystrophin-deficient dogs. Molecular Therapy advance online publication 1 June 2010. doi:10.1038/mt.2010.94, 18(8):1501-1508, 2010. 92. Weig SG, Zinn M, Howard JF: Idiopathic Intracranial Hypertension as a complication of chronic corticosteroid treatment in Duchenne Muscular Dystrophy. Pediatric Neurology 45:406-408, 2011. 93. Fan Z, Kocis K, Valley R, Howard JF, Chopra M, An H, Lin W, Muenzer J, Powers W: Safety and feasibility of transvenous limb perfusion in human. Molecular Therapy 20(2):456-61, 2012. doi: 10.1038/mt.2011.137. Epub 2011 Jul 19 94. Kornegay JN, Childers MK, Bogan DJ, Bogan JR, Nghiem P, Wang J, Fan Z, Howard JF, Schatzberg SJ, Dow JL, Grange RW, Styner MA, Hoffman EP, Wagner KR: The paradox of muscle hypertrophy in muscular dystrophy. In: Carter GT (ed). Recent Advancements in Neuromuscular Medicine. Physical Medicine and Rehabilitation Clinics of North America 23(1): 149–172; 2012 doi:10.1016/j.pmr.2011.11.014. 95. Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Grange RW, Bhavaraju-Sanka RK, Tou S, Keene BP, Howard JF, Wang J, Fan Z, Schatzberg SJ, Styner MA, Flanigan KM, Xiao X, Hoffman EP: Canine models of Duchenne Muscular Dystrophy and their use in therapeutic strategies. Mammalian Genome 23(1-2):85-108, 2012; Jan 5, doi 10.1007/s00335-011-9382-y Epub 2012 Jan 5. 96. Benatar M, Sanders DB, Burns TM, Cutter GR, Guptill JT, Baggi F, Kaminski HJ, Mantegazza R, Meriggioli MN, Quan J, Wolfe GI; The Task Force on MG Study Design of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America (Howard JF): Recommendations for myasthenia gravis clinical trials. Muscle Nerve 2012 Jun;45(6):909-917. doi: 10.1002/mus.23330. 97. Howard JF: The electrodiagnosis of disorders of the neuromuscular junction. In The Electrodiagnosis of Neuromuscular Disorders, edit.MD Weiss, Physical Medicine and Rehabilitation Clinics of North America. 24(1):169-192, 201, doi: 10.1016/j.pmr.2012.08.013. Epub 2012 Oct 26. 98. Scola MR, Caughey MC, Meyer DO, Emmett R, Howard JF, Chopra M, Gallippi CM: Viscoelastic Strain Response (ViSR) ultrasound assessment of viscoelastic properties in human duchenne muscular dystrophy, in vivo. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 1355-1358). [6562123] DOI: 10.1109/ULTSYM.2012.0338. 99. Pasnoor M, He J, Herbelin L, Dimachkie M, Barohn, R, and the Muscle Study Group (Howard JF Jr): Phase II trial of methotrexate in myasthenia gravis. Ann. N.Y. Acad. Sci. 1275 (2012) 23–28, 2012. doi: 10.1111/j.1749-6632.2012.06804.x 100. Zeng XL. Nagavalli A, Smith C-J, Howard JF, Su MA: Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. Journal of Immunology. 190(8):3895-3904, 2013; published ahead of print March 13, 2013, doi:10.4049/jimmunol.1203001. 101. Howard JF, R Barohn R, Cutter G, Freimer M, Juel V, Mozaffar T, Mellion M, Benatar M, Farrugia M, Wang JJ, Malhotra SS, Kissel JT: A Randomized, Double-Blind, Placebo-Controlled Phase II Study of Eculizumab in Patients with Refractory Generalized Myasthenia Gravis. Muscle Nerve. 48(1): 76-84, 2013, Mar 20, 2013. doi: 10.1002/mus.23839. [Epub ahead of print]. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 32

102. Scola MR, Kornegay JN, Howard JF, Nichols TC, Gallippi CM: Viscoelastic strain response (ViSR) ultrasound in pre-clinical and clinical application. In Biomedical and Biotechnology Engineering (Vol. 3 B). American Society of Mechanical Engineers (ASME). DOI: 10.1115/IMECE2013-65596. 103. Papsdorf TB, Howard JF, Chahin N: Pearls & Oy-sters: Clues to the diagnosis of adult onset acid maltase deficiency. Neurology; 82(9):e73-5, 2014. doi:10.1212/WNL.0000000000000163.

104. Parnell BA, Howard JF Jr, Geller EJ: The effect of sacral neuromodulation on pudendal nerve function and female sexual function. Neurourol Urodyn. 2014 Feb 24. doi: 10.1002/nau.22579. [Epub ahead of print] 105. Bhavaraju-Sanka R, Howard JF, Chahin N: Atypical McArdle’s disease with asymmetric weakness and atrophy. SOJ Neurology 1(1):1-3, 2014. doi: http://dx.doi.org/10.15226/2374- 6858/1/2/00107 106. Renton AE, Pliner HA, Provenzano C, Evoli A, Ricciardi R, Nalls MA, Marangi G, Abramzon Y; Arepalli S, Chong S, Hernandez DG, Johnson JO, Bartoccioni E, Scuderi F; Maestri M, Gibbs JR, Errichiello E; Chiò A, Restagno G, Sabatelli M, Macek M, Scholz SW, Corse A, Chaudhry V, Benatar M, Barohn RJ, McVey A, Pasnoor M, Dimachkie MM, Rowin J, Kissel J, Freimer M, Kaminski HJ, Sanders DB, Lipscomb B, Massey JM, Chopra M, Howard JF Jr, Koopman WJ, Nicolle MW, Pascuzzi RM, Pestronk A, Wulf C; Florence J, Blackmore D, Soloway A, Siddiqi Z, Muppidi S, Wolfe G, Richman D, Mezei MM, Jiwa T; Oger J, Drachman DB, Traynor BJ: A Genome-wide Association Study of Myasthenia Gravis. JAMA Neurol. 72(4):396-404, 2015. doi:10.1001/jamaneurol.2014.4103 published online February 2, 2015. PMID: 25643325 107. Guptill JT, Yi JF, Sanders DB, Guidon AC, Juel VC, Massey JM, Howard JF Jr, Scuderi F, Bartoccioni E, Evoli A, Weinhold KJ: Characterization of B Cells in Muscle Specific Kinase Antibody Myasthenia Gravis. Neurology Neuroimmunology & Neuroinflammation Published online February 26, 2015 doi: 10.1212/NXI.0000000000000077, April 2015 vol. 2 no. 2 e77. 108. Sanders DB, Rosenfeld J, Dimachkie MM, Meng L, Malik FI, Tirasemtiv in Myasthenia Gravis Study Group (Howard JF Jr): A double-blinded, randomized, placebo-controlled trial to evaluate efficacy, safety, and tolerability of single doses of tirasemtiv in patients with acetylcholine receptor-binding antibody-positive myasthenia gravis. Neurotherapeutics. Apr;12(2):455-460, 2015. doi: 10.1007/s13311-015-0345-y. PMID: 25745635. 109. Wang M, Cheshire WP, Howard JF: Spinal cord infarction. In Neurovascular Surgery, 2nd edition, edit., RF Spetzler, M Yashar S Kalani, P Nakaji, Theime Publishers, Chapter 30., 2015. 110. Fan Z, Kocis K, Valley R, Howard JF Jr, Chopra M, Chen Y, An H, Lin W, Muenzer J, Powers W: High-pressure Transvenous Perfusion of the Upper Extremity in Human Muscular Dystrophy: A Safety Study with 0.9% Saline. Human Gene Therapy 26(9):614-621, 2015. doi: 10.1089/hum.2015.023. Epub 2015 Jul 30. PMID: 25953425 111. Papsdorf TB, Howard JF, Chahin N: Late-onset Becker Muscular Dystrophy: Refining the clinical features and electrophysiological findings. Muscle Nerve 52(5):885-887, 2015. doi: 10.1002/mus.24773. Epub 2015 Sep 10. 112. Moore CJ, Selzo MR, Caughey MC, Meyer DO, Emmett R, Howard JF, Chopra M, Gallippi CM: Viscoelastic Response (VisR) assessment of longitudinal dystrophic degeneration in clinical Duchenne muscular dystrophy In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329534] Institute of Electrical and Electronics Engineers Inc.. DOI: 10.1109/ULTSYM.2015.0225. 113. Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EAD, Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 33

Donofrio PD, Dyck PJB, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM, Hehir MK, Hobson-Webb LD, Howard JF Jr, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel, JT, Kolb, N, Lacomis, D, Ladha, S, Larriviere, D, Lewis, RA, Li, Y, Litchy, WJ, Logigian E, Lou J-S, MacGowen DJL, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon J-S, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi, RM, Peltier, A, Ruzhansky, K, Richman, DP, Ross, MA, Rubin, DI, Russell, JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI: Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. Muscle Nerve. 53(2):165-8, 2016. doi: 10.1002/mus.25009. Epub 2015 Dec 21. 114. Howard JF Jr: Targeting the Complement System in Refractory Myasthenia Gravis. Neurology Reviews. 24(suppl): S1-S4, 2016. 115. Pasnoor M, He J, Herbelin L, Burns TM, Nations S, Bril V, Wang AK, Elsheikh BH, Kissel JT, Saperstein D, Shaibani JA, Jackson C, Swenson A, Howard JF Jr, Goyal N, David W, Wicklund M, Pulley M, Becker M, Mozaffar T, Benatar M, Pazcuzzi R, Simpson E, Rosenfeld J, Dimachkie MM, Statland JM, Barohn RJ; Methotrexate in MG Investigators of the Muscle Study Group. A randomized controlled trial of methotrexate for patients with generalized myasthenia gravis. Neurology. 87(1):57-64, 2016. doi: 10.1212/WNL.0000000000002795. Epub 2016 Jun 15. PMID: 27306628. 116. Guptill JT, Juel VC, Massey JM, Anderson AC, Chopra M, Yi JS, Esfandiari E, Buchanan T, Smith BS, Atherfold PA, Jones E, Howard JF Jr: Effect of Therapeutic Plasma Exchange on Immunoglobulins in Myasthenia Gravis. Autoimmunity 49(7):472-479, 2016. PMID: 27684107. 117. Soim A, Lamb M, Campbell K, Pandya S, Peay H, Howard, JF Jr., Fox D and the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet): A cross-sectional study of school experiences of boys with Duchenne and Becker muscular dystrophy. Physical Disabilities: Education and Related Services 35(2); 1-22, 2016; doi: 10.14434/pders.v35i2.21765. 118. Moore CJ, Selzo MR, Caughey MC, Meyer DO, Emmett R, Howard JF, Chopra M, Gallippi CM: (2016). Cross-sectional comparison of in vivo Viscoelastic Response (VisR) ultrasound in lower limb muscles of boys with and without duchenne muscular dystrophy. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728722] IEEE Computer Society. DOI: 10.1109/ULTSYM.2016.7728722. 119. Howard JF Jr, Freimer M, O’Brien F, Wang JJ, Kissel JT on behalf of the MG Study Group: QMG and MG-ADL Correlations: Study of Eculizumab Treatment of Myasthenia Gravis. Muscle Nerve 2016 Dec 23. doi: 10.1002/mus.25529. [Epub ahead of print]. PMID: 28010051. 120. Richards J, Howard JF Jr: Seronegative myasthenia gravis associated with malignant thymoma. Neuromuscular Disorders. 27:417-418, 2017, http://dx.doi.org/doi:10.1016/j.nmd.2017.01.023. 121. Juel VC, Sanders DB, Hobson-Webb LD, Massey JM, Guptill JT, O’Brien F, Wang JJ, Howard JF Jr: Marked Clinical and Jitter Improvement after Eculizumab in Refractory Myasthenia. Muscle Nerve 2017 Feb 18. doi: 10.1002/mus.25620. [Epub ahead of print] PMID: 28214342. 122. Guglieri M, Bushby K, McDermott MP, Hart KA, Tawil R, Martens WB, Herr BE, McColl E, Wilkinson J, Kirschner J, King WM, Eagle M, Brown MW, Willis T, Hirtz D, Shieh PB, Straub V, Childs AM9, Ciafaloni E3, Butterfield RJ10, Horrocks I11, Spinty S12, Flanigan KM13, Kuntz NL14, Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 34

Baranello G, Roper H, Morrison L, Mah JK, Manzur AY, McDonald CM, Schara U, von der Hagen M, Barohn RJ, Campbell C, Darras BT, Finkel RS, Vita G, Hughes I, Mongini T, Pegoraro E, Wicklund M, Wilichowski E, Bryan Burnette W, Howard JF, McMillan HJ, Thangarajh M, Griggs RC: Developing Standardized Corticosteroid Treatment for Duchenne Muscular Dystrophy. Contemp Clin Trials. 2017 Apr 24. pii: S1551-7144(16)30261-0. doi: 10.1016/j.cct.2017.04.008. [Epub ahead of print] PMID: 28450193. 123. Lewis MJ, Howard JF Jr, Olby N: The relationship between trans-lesional conduction, motor neuron pool excitability and motor function in dogs with incomplete recovery from severe spinal cord injury. Journal of Neurotrauma May 2017, ahead of print. doi:10.1089/neu.2017.5012. PubMed PMID: 28462632 124. Jovanovich EN, Howard JF Jr: Brachial Plexus Injury in 6 Year Old Boy with 100% Displaced Proximal Humeral Metaphyseal Fracture. PM&R June 9, 2017, [Epub ahead of print]. doi:/10.1016/j.pmrj.2017.05.009. PubMed PMID: 28606839. 125. Hehir MK, Hobson-Webb LD, Benatar M, Barnett C, Silvestri NJ, Howard JF Jr, Howard D, Visser A, Crum BA, Nowak R, Beekman R, Kumar A, Ruzhansky K, Chen IA, Pulley MT, LaBoy SM, Fellman MA, Greene SM, Pasnoor M, Burns TM. Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective review. Neurology. 2017 Aug 11. pii: 10.1212/WNL.0000000000004341. doi: 10.1212/WNL.0000000000004341. [Epub ahead of print] PubMed PMID: 28801338. 126. Dyck PJB, Howard JF Jr, Chahin N: Caroline M. Klein, PhD (1960-2017). Neurology. 2017;89:760- 761. DOI 10.1212/WNL.0000000000004279. 127. Howard JF Jr, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Sendra II, Jacob S, Vissing J, Burns TM, Kissel JT, Muppidi S, Nowa RJ, O’Brien F, Wang JJ, Mantegazza R and the REGAIN Study Group: REGAIN: A randomized, double-blind, placebo-controlled, multi-centre study to evaluate the safety and efficacy of eculizumab in patients with anti-acetylcholine receptor-positive refractory generalized myasthenia gravis. Lancet Neurology. 2017-Oct 20. doi: http://dx.doi.org/10.1016/S1474-4422(17)30369-1. [Epub ahead of print]. 128. Benatar MB, Howard JF Jr, Barohn R, Wolfe GI, Cutter G: Learning from the Past: Reflections on Recently Completed MG Trials. Annals New York Acad Sci. 2017-Oct. doi:10.1111/nyas.13501. [Epub ahead of print]. 129. Howard JF Jr: Myasthenia Gravis: the role of complement at the neuromuscular junction. Annals New York Acad Sci. (in press). 130. Moore C, Caughey M, Chopra M, Howard Jr JF, Gallippi C: Estimating Degree of Mechanical Anisotropy in Dystrophic and Control Rectus Femoris in Boys Using VisR Ultrasound. Proceedings of the 2017 IEEE International Ultrasonics Symposium (IUS). (in press). 131. Davis RA, Hart KA, Bushby K, McDermott MP, Tawil R, Martens WB, Herr BE, McColl E, Wilkinson J, Kirschner J, King WM, Eagle M, Brown MW, Hirtz D, Lochmuller H, Straub V, Ciafaloni E, Shieh PB, Spinty S, Childs A-M, Manzur AY, Morandi L, Butterfield RJ, Horrocks I, Roper H, Flanigan KM, Kuntz NL, Mah JK, Morrison L, Darras BT, von der Hagen M, Schara U, Wilichowski E, Mongini T, McDonald CM, Vita G, Barohn RJ, Finkel RS, Wicklund M, McMillan HJ, Hughes I, Pegoraro E, Bryan Burnette W, Howard JF, Thangarajh M, Campbell C, Griggs RC, Bushby K, Guglieri M: A checklist for clinical trials: obstacles and anticipatory actions (submitted). 132. Allard D, Zeng X, Wang Y, Smith C-J, Conley B, Kimpston C, Notini R, Howard Jr JF, Scherer S, Su M: DX5/CD49b identifies an expanded population of Schwann cells associated with C1q in autoimmune peripheral neuropathy. (submitted). Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 35

133. Smith C-J, Trout DA, Wang Y, Howard Jr JF, Montgomery SA, Su MA: IL-10 paradoxically promotes autoimmune polyneuropathy through S1pr1-dependent T cell migration. (submitted). 134. Sanford TS, Hill JJ, Harris MG, Cockman M, Howard JF: Correlation between ultrasound measures of the median nerve and electrodiagnostic severity of median mononeuropathy separated by gender (submitted).

BOOK CHAPTERS 1. Sanders DB, Howard JF, Johns TR, Campa JF: High-dose daily prednisone therapy in myasthenia gravis. In Plasmapheresis and the Immunobiology of Myasthenia Gravis, edit., P.C. Dau, Houghton Mifflin Professional Publishers, Boston. Chapter 27:289-306, 1979. 2. Howard JF, Sanders DB: The management of patients with myasthenia gravis. In Myasthenia Gravis, edit., E.X. Albuquerque and A.T. Eldefrawi, Chapman and Hall Ltd., London, Chapter 15:457-489, 1983. 3. Sanders DB, Howard JF: Disorders of Neuromuscular transmission. Chapter 82, In Neurology in Clinical Practice, edit., W.G. Bradley, R.B. Daroff, G.M. Fenichel, C.D. Marsden, Butterworth Publishers, pp 1819-1842, 1990. 4. Hall, C.D., Howard JF, Donohue JF: The ventilatory support of patients with neuromuscular disorders. In Muscular Dystrophy and Other Neuromuscular Diseases: Psychosocial Issues, edit., L.I. Charash, R.E. Lovelace, C.F. Leach, A.H. Kushner, J. Goldberg, D. Price Roy, The Haworth Press, New York, 1991. 5. Sanders DB, Howard JF: Disorders of Neuromuscular Transmission. In Neurology in Clinical Practice, edit., W.G. Bradley, R.B. Daroff, G.M. Fenichel, C.D. Marsden, Butterworth Publishers, 2nd edition Chapter 83 pp. 1983-2002, 1995. 6. Howard JF: Myasthenia gravis in the elderly. In Practical Neurology of the Elderly, edit., M. Mark, J. Sage, Marcel Dekker, Inc., Chapter 5 pp. 189-236, 1996. 7. Howard JF: Myasthenia Gravis. In Conn's Current Therapy, edit., R.E. Rakel, W.B. Saunders Co pp. 893-900, 1996. 8. Howard JF: Evaluation and Treatment of Low Back Pain. In Neurology of Trauma, edit., R.W. Evans, W.B Saunders Co. Chapter 19, pp 333-362, 1996. 9. Conti-Fine BM, Wang Z-W, Raju R, Howard JF, Navaneetham D: Anti-acetylcholine receptor CD4+ T cells in myasthenia gravis: Epitope repertoire and T cell receptor gene usage. In Myasthenia Gravis: Disease Mechanisms and Immunosuppression. edit., P. Christadoss, Narosa Publishing House, New Delhi, India, Chapter 8 pp .73-93, 2000. 10. Wang Z-Y, Karachunski PI, Howard JF, Conti-Fine BM: Passive myasthenia gravis induced in SCID mice by transfer of blood cells form myasthenic patients. Myasthenia Gravis: Disease Mechanisms and Immunosuppression. edit., P. Christadoss, Narosa Publishing House, New Delhi, India, Chapter 12 pp .125-142, 2000. 11. Sanders DB, Howard JF: Disorders of Neuromuscular Transmission. In Neurology in Clinical Practice, edit., W.G. Bradley, R.B. Daroff, G.M. Fenichel, C.D. Marsden, Butterworth Publishers, 3rd edition Chapter 82 pp. 2167-2185, 2000. 12. Howard JF: Myasthenia gravis. In Essence of Office Pediatrics, edit., J.A. Lohr and J.A. Stockman III, W. B. Saunders Co. Philadelphia, p. 270, 2001. 13. Howard JF: Congenital Myasthenic Syndromes. In Neuromuscular Disorders: Expert Clinician’s Views, edit R. Pourmand, W.B. Saunders Co. Chapter 14, pp. 459-474, 2001. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 36

14. Howard JF: The Neurotoxicity of Neuromuscular Transmission. In Neuromuscular Disorders in Clinical Practice. edit., B Katirji, HJ Kaminski, DC Preston, RL Ruff, BE Shapiro. Butterworth- Heinemann, Chapter 54, pp. 964-986, 2002. 15. Howard JF: Neuromuscular transmission. In Neuromuscular Function and Disease. Basic, Clinical and Electrodiagnostic Aspects. Volume 1, Chapter 21, edit., W Brown, C Bolton, M Aminoff, W.B. Saunders Co. Chapter 21, pp. 401-413, 2002. 16. Howard JF: Toxic Neuromuscular Transmission Disorders. In Myasthenia Gravis and Related Disorders, edit., H.J. Kaminski, Humana Press. Chapter 15, pp 327-354, 2003. 17. Howard JF: Myasthenia Gravis. In Conn's Current Therapy 2003, edit., R.E. Rakel, W.B. Saunders Co pp. 1007-1016, 2003. 18. Howard JF: Myasthenia Gravis. In Netter's Internal Medicine. edit., MS Runge and MA Greganti, Icon Learning Systems LLC. Chapter102, pp 679-684, 2003. 19. Howard JF. Peripheral Neuropathy. In Netter's Internal Medicine. edit., MS Runge and MA Greganti, Icon Learning Systems LLC. Chapter105, pp 694-700, 2003. 20. Howard JF: Repetitive Nerve Stimulation. In EMG Secrets. edit., FC Tan, Hanley & Belfus, Inc. Chapter 12, pp 71-78, 2003. 21. Howard JF: Structure and Function of the Neuromuscular Junction. In Clinical Neurophysiology of Disorders of Muscle and Neuromuscular Junction, Including Fatigue, edit., E. Stålberg. IFCN Handbook of Clinical Neurophysiology, edit., J.R. Daube, F. Mauguière, Elsevier Press Vol. 2, Chapter 3, pp. 27-46, 2003. 22. Sanders DB, Howard JF: Disorders of Neuromuscular Transmission. In Neurology in Clinical Practice, edit., W.G. Bradley, R.B. Daroff, G.M. Fenichel, J Jankovic, Butterworth-Heinemann Publishers, 4th edition, Chapter 84 pp. 2441-2461, 2004. 23. Howard JF: Evaluation and Treatment of Low Back Pain. In Neurology of Trauma, edit., R.W. Evans, Oxford University Press. 2nd edition, Chapter 16, pp 302-336, 2006. 24. Sanders DB, Howard JF: Disorders of Neuromuscular Transmission. In Neurology in Clinical Practice, edit., W.G. Bradley, R.B. Daroff, G.M. Fenichel, J Jankovic, Butterworth-Heinemann Publishers, 5th edition Chapter 82 pp. 2383-2402, 2008. 25. Howard JF and Sanders DB: Neurotoxicology of Neuromuscular Transmission. In Handbook of Clinical Neurology, edit. M.J. Aminoff, F. Boller, D. F. Swaab, Vol. 91, Neuromuscular Junction Disorders, edit, A.G. Engel, Elsevier. Chapter 12 pp. 369-400, 2008. DOI: 10.1016/S0072- 9752(07)01512-6, PMID 18631850. 26. Howard JF: Historical Notes. In Myasthenia Gravis. A Manual for the Health Care Provider, edit., JF Howard, Myasthenia Gravis Foundation of America, Inc. pp. 2-5, 2008. 27. Howard JF: Physician Issues in Myasthenia Gravis. In Myasthenia Gravis. A Manual for the Health Care Provider, edit., JF Howard, Myasthenia Gravis Foundation of America, Inc. pp. 6-31, 2008. 28. Howard JF: Guidelines for the Pharmacist. In Myasthenia Gravis. A Manual for the Health Care Provider, edit., JF Howard, Myasthenia Gravis Foundation of America, Inc. pp. 108-113, 2008. 29. Howard JF: Myasthenia Gravis. In Netter's Internal Medicine. edit., MS Runge and MA Greganti, 2nd edition, Saunders Elsevier. Chapter134, pp 941-946, 2009. 30. Howard JF, Klein C. Peripheral Neuropathy. In Netter's Internal Medicine. edit., MS Runge and MA Greganti, 2nd edition, Saunders Elsevier. Chapter123, pp 863-872, 2009. 31. Howard JF: Toxic Neuromuscular Transmission Disorders. In Myasthenia Gravis and Related Disorders, 2nd edition, edit., H.J. Kaminski, Humana Press, Chapter 16, pp. 255-277, 2009. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 37

32. Howard JF Jr, Klein C. Neuropathie périphérique. In Médecine interne de Netter. edit., MS Runge and MA Greganti, 2nd edition, Elsevier Masson SAS. Chapter123, pp 942-951, 2011. 33. Howard JF: Myasthénie. In Médecine interne de Netter. edit., MS Runge and MA Greganti, 2nd edition, Elsevier Masson SAS. Chapter134, pp 1028-1034, 2011. 34. Howard JF: The diagnosis of myasthenia gravis and other disorders of neuromuscular transmission. Myasthenia Gravis and Myasthenic Disorders (2nd edition) edit. AG Engel, Oxford University Press, New York, Chapter 5, pp108-129, 2012. 35. Howard JF: Toxic Neuromuscular Transmission Disorders. In Neuromuscular Disorders in Clinical Practice. edit., B Katirji, HJ Kaminski, RL Ruff. Springer, Chapter 52, pp. 1129-1148, 2013. 36. Howard JF: Electrodiagnóstico de Trastornos de transmisión neuromuscular (Electrodiagnosis of Disorders of Neuromuscular Transmission). In Miastenia Gravis y problems relacionados (Myasthenia Gravis and Related Problems) 1st edition, edit C Mazia, Editorial Inter-Medica – S.A.I.C.I., Buenos Aires, Chapter 17, pp.239-256, 2017.

BOOKS 1. Conti-Fine BM, Protti MP, Belone M, Howard JF: Myasthenia Gravis and its Experimental Model: The Immunobiology of an Autoimmune Disease. Landes Bioscience Publishers, Georgetown, TX. 1997. 2. Meriggioli, MN, Howard JF, Harper CM: Neuromuscular Junction Disorders: Diagnosis and Treatment. Marcel Dekker, Inc., New York. 2004. 3. Howard JF (editor): Myasthenia Gravis. A Manual for the Health Care Provider. Myasthenia Gravis Foundation of America, Inc., St. Paul, MN, 2008.

ELECTRONIC PUBLICATIONS 1. Howard JF: Department of Neurology, The University of North Carolina at Chapel Hill, Web Pages. http://www.med.unc.edu/neurolog/. 1996 — 2001. Pages moved to the departmental server 07/01 and administered by the Computer Systems Administrator. 2. Howard JF: National Myasthenia Gravis Foundation of America, Web Pages. http://www.med.unc.edu/mgfa/. 1996 — 1998. Pages moved to Myasthenia Gravis Foundation server 11/98 and administered by the MGFA Information Technology Committee. 3. Howard JF: North Carolina Chapter of the National Myasthenia Gravis Foundation of America, Web Pages. http://www.med.unc.edu/mgfa/mgnc-hom.htm/. 1996 — 2008; administration moved to the National Myasthenia Gravis Foundation of America. 4. Howard JF: Myasthenia Gravis: A Summary. http://www.myasthenia.org/hp_clinicaloverview.cfm 1997; updated 2006. 5. Patton L, Howard JF: Myasthenia Gravis: Dental Treatment Considerations. http://www.myasthenia.org/information/dental.htm. 1998. 6. Howard JF Jr: Where’s the research? http://www.myasthenia.org/news/vol1-is1.htm#Where's the Research. 1998. 7. Howard JF Jr (editor): Myasthenia Gravis. A Manual for the Health Care Provider. Myasthenia Gravis Foundation of America, Inc., St. Paul, MN, 2008. 8. Howard JF Jr (editor): Myasthenia Gravis. A Manual for the Health Care Provider (CD-ROM format). Myasthenia Gravis Foundation of America, Inc., St. Paul, MN, 2008. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 38

9. Sanders DB, Howard JF Jr, Burns T (moderator): Collaborations and Consortia - Critical for Research in Rare Diseases. A podcast presented at the Annual Meeting of the National Myasthenia Gravis Foundation of America. Charlotte NC, May 2009. [slide set]. 10. Howard JF Jr, Wolf, G, Burns T (moderator): A podcast; What the patient and caregiver should know about prescription drugs and MG. Myasthenia Gravis Foundation of America., New York, NY, http://www.myasthenia.org/LivingwithMG/PodcastEducationalSeries.aspx.March 2010. 11. Wang M, Cheshire WP, Howard JF Jr: Spinal cord infarction. In Neurovascular Surgery, 2nd edition, edit., RF Spetzler, M Yashar S Kalani, P Nakaji, Theime Publishers, Kindle Edition, Chapter 30., ISBN 978-1-60406-760-6 (ebook), 2015. 12. Howard JF Jr (editor): Myasthenia Gravis. A Manual for the Health Care Provider. Myasthenia Gravis Foundation of America, Inc., St. Paul, MN, 2008; reprinted as iBook 2015. 13. Howard JF Jr: Rare Insight: A Physician’s Perspective on Myasthenia Gravis. https://globalgenes.org/raredaily/rare-insight-a-physicians-perspective-on-myasthenia-gravis/. June 30, 2015. 14. Howard JF Jr: Dr James Howard Discusses the Efficacy of Soliris in Myasthenia Gravis. Rare Disease Report. http://www.raredr.com/news/dr-james-howard-soliris-mg. [https://youtu.be/6cICCm-B6JU] July 8, 2016. 15. Howard JF Jr: The complement system in refractory myasthenia gravis. http://www.mdedge.com/neurologyreviews/article/112655/complement-system-refractory- myasthenia-gravis. Neurology Reviews September 8, 2016. 16. Howard JF Jr: The role of complement system in myasthenia gravis. https://www.youtube.com/watch?v=0yS2f_tNGa4. University of Washington Medicine Neurosciences Institute. October 1, 2016.

ABSTRACTS 1. Howard JF, Freedman SL: Morphology, incidence and luminal material of Wolffian ducts in the chicken (Gallus domesticus). Anatomical Record 169:343-344, 1971. 2. Sanders DB, Howard JF, Johns TR: Single-fiber electromyography in myasthenia gravis. Neurology 27:353, 1977. 3. Sanders DB, Howard JF, Johns TR: Single-fiber electromyography in myasthenia gravis. Electroencephalography and Clinical Neurophysiology 43:588, 1977. 4. Sanders DB, Howard JF, Johns TR, Campa JR: High-dose daily prednisone therapy in myasthenia gravis. Muscle & Nerve 1(4):342, 1978. 5. Howard JF, Sanders DB: Passive transfer of human myasthenia gravis to rats: l. Electrophysiology of the developing neuromuscular block. Neurology 28:346, 1978. 6. Howard JF, Sanders DB: Plasma exchange in the treatment of myasthenia gravis. Archives of Neurology 36:251, 1979. 7. Kim YI, Howard JF, Sanders DB: Depressant effects of morphine and meperidine on neuromuscular transmission in rat and human myasthenic muscles. Society for Neuroscience Abstracts 5:482, 1979. 8. Sanders DB, Howard JF: Single-fiber EMG in the diagnosis of myasthenia gravis. Muscle & Nerve 4:253, 1981. 9. Howard JF, Sanders DB: Serial single-fiber EMG studies in myasthenic patients treated with corticosteroids and plasma exchange. Muscle & Nerve 4:254, 1981. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 39

10. Quint, SR, Howard JF: On-line analysis of neuromuscular bioelectric potentials. Proceedings of the 34th Annual Conference on Engineering in Medicine and Biology 23:82, 1981. 11. Howard JF, Johnson BR: Depressant effect of Timolol, a beta adrenergic blocker, on neuromuscular transmission in normal and myasthenic muscles. Society for Neuroscience Abstracts 7:105, 1981. 12. Johnson BR, Howard JF: Facilitatory effects of ethanol on neuromuscular transmission in intercostal muscle from patients with myasthenia gravis Society for Neuroscience Abstracts 7:315, 1981. 13. Sanders DB, Kim YI, Howard JF, Goetsch CA: Eaton-Lambert syndrome: A clinical and electrophysiological study of a patient treated with 4-aminopyridine. Muscular Dystrophy Abstracts 25:151, 1981. 14. Sanders DB, Howard JF: Serial studies in myasthenia gravis: The effects of treatment on jitter. Muscle and Nerve 5:551, 1982. 15. Behlmer P, Howard JF, Silverman LM: CSF immunological differentiation of CNS sarcoidosis from multiple sclerosis. Neurology 33 (Suppl 2):71, 1983. 16. Sanders DB, Howard JF: A comparison of the diagnostic sensitivity of single-fiber EMG and acetylcholine receptor antibody titer in myasthenia gravis. Neurology 33 (Suppl 2):141, 1983. 17. Martinkosky SJ, Howard JF, Finley CC, Quint SR: Pre and post plasmapheresis treatment measures obtained from myasthenic patients. ASHA 25:116-117, 1983. 18. Quint SR, Greenwood RS, Howard JF, Gomez VJ: Automated data-acquisition and analysis of neural evoked potentials. Proceedings of the 37th Annual Conference on Engineering in Medicine and Biology 26:358, 1984. 19. Shy ME, Lange DJ, Howard JF, Gold AP, Lovelace RE, Penn AS: Quinidine exacerbating myasthenia gravis: a case report and intracellular recordings. Annals of Neurology 18:120, 1985. 20. Massey JM, Sanders DB, Howard JF: Use of single fiber electromyography to predict the course of ocular myasthenia. Muscle & Nerve 8:624, 1985. 21. Cook L, Howard JF, Folds JD: Immediate effects of IV IgG administration on peripheral blood B and T cells and PMNs in patients with myasthenia gravis. Federation Proceedings 45:1003, 1986. 22. Howard JF: Single-fiber EMG and intracellular recording, two methods to study neuromuscular transmission. Muscle and Nerve 9(Suppl 5S):82, 1986. 23. Howard JF, Cook L, Folds JD: Intravenous gamma globulin for the treatment of myasthenia gravis: Clinical, electrophysiological and immunological correlations. Muscle and Nerve 9(Suppl 5S): 155, 1986. 24. Massey JM, Sanders DB, Howard JF: The effect of cholinesterase inhibitors on single-fiber electromyography in myasthenia gravis. Muscle and Nerve 9:660, 1986. 25. Sanders DB, Howard JF: Single-fiber electromyography in myasthenia gravis. Muscular Dystrophy Abstracts 31:126, 1987. 26. Sanders DB, Howard JF, Massey JM, Mihovilovic M, Olanow CW, Roses AD, Stewart CR: Seronegative myasthenia gravis. Annals of Neurology 22:126, 1987. 27. Howard JF, Johnson BR, Quint SR: The effects of beta-adrenergic antagonists on neuromuscular transmission in rat skeletal muscle. Society for Neuroscience Abstracts 13:147, 1987. 28. Massey JM, Sanders DB, Howard JF: The effect of cholinesterase inhibitors on single-fiber electromyography in myasthenia gravis. Electroencephalography and Clinical Neurophysiology 67:100P, 1987. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 40

29. Cook L, Howard JF, Folds JD: Immediate effects of intravenous IgG administration on peripheral blood B- and T-cells and PMNs in patients with myasthenia gravis. Muscular Dystrophy Abstracts 32:191, 1988. 30. Royal ME, Howard JF: Muller's muscle injury with ptosis mimicking myasthenia gravis. Neurology 39:307, 1989. 31. Sanders DB, Massey JM, Howard JF: 3,4-Diaminopyridine in myasthenia gravis and Lambert- Eaton syndrome. Neurology 39:267, 1989. 32. Massey JM, Sanders DB, Howard JF: The effect of cholinesterase inhibitors on SFEMG in myasthenia gravis. Muscular Dystrophy Abstracts 33:263, 1989. 33. Cheshire WP, Santos CS, Howard JF, Massey EW: Spinal cord infarction - etiology and outcome. Neurology 40(Suppl 1):325, 1990. 34. Howard JF, Campbell WW: Thymic cyst and myasthenia gravis: mistaken identity for thymoma. Neurology 40(Suppl 1):348, 1990. 35. Massey JM, Sanders DB, Howard JF: Sensitivity of diagnostic tests in myasthenia gravis. Neurology 40(Suppl 1):348, 1990. 36. Dvergtsen CL, Meeker RB, Howard JF: Down regulation of muscarinic receptors in rats due to early post natal exposure to parathion. Society for Neuroscience Abstracts 17 (Part 2): 1466, 1991. 37. Hopkins AL, Howard JF, Stewart CR, Wheeler SJ, Kornegay JN: Stimulated single fiber electromyography in normal dogs. Journal of Veterinary Internal Medicine 5:136, 1991. 38. Howard JF, Donovan MK, Tucker MS: Urinary incontinence in myasthenia gravis: A single fiber electromyographic study. Annals of Neurology 32:282, 1992. 39. Donovan MK, Weissler MC, Martinkosky SJ, Howard JF: Serial single fiber electromyographic studies in patients with focal laryngeal dystonia following Botulinum A toxin injections. Annals of Neurology 32:254, 1992. 40. Jaradeh SS, D'Cruz OF, Howard JF, Haberkamp TJ, Konkol RJ: Möbius syndrome: Electrophysiological studies in six cases. Muscle & Nerve 15:1175, 1992. 41. Howard JF, Weiss AS, Donovan MK, Cheshire WP, Braun TG: 3,4-Diaminopyridine effects on compound muscle action potential amplitudes in a patient with botulism. Muscle & Nerve 15:1202-1203, 1992. 42. Martinkosky SJ, Whitsell DL, Weissler MC, Howard JF, Donovan MK: Longitudinal measurement of laryngeal resistance before and after BOTOX injections. ASHA 34:171, 1992. 43. Finkel AG, Howard JF, Mann JD: Successful treatment of headache related to intravenous immunoglobulin (IVIG) with antimigraine medications: a case report. Neurology 44(S2): A200, 1994. 44. Finkel AG, Howard JF, Mann JD: Headache related to intravenous immunoglobulin: Case reports and literature review. Cephalalgia 15(Supp 14): 76, 1995. 45. Wang Z-W, Okita D, Howard JF, Conti-Fine BM: CD4+ cells in myasthenia gravis recognize the  subunit of human muscle acetylcholine receptor. Journal of Neuroimmunology 92:4, 1998. 46. Navaneethan D, Penn AS, Howard JF, Conti-Fine BM: Thymus and blood TCR Vβ usage in myasthenia gravis patients. Journal of Neuroimmunology 92:4, 1998. 47. Wang Z-W, Karachunski PI, Howard JF, Conti-Fine BM: Myasthenia in SCID mice engrafted with blood lymphocytes form myasthenia gravis patients. Role of CD4+ and CD8+ cells. Journal of Neuroimmunology 92:4, 1998. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 41

48. Owen HG, Brecher ME, Howard JF, Bandarenko N: Minimizing hypovolemic reactions with 3% hetastarch replacement during therapeutic plasma exchange. Journal of Clinical Apheresis 14:91, 1999. 49. York JA, Howard JF, Braun TG, Hall CD, D’Cruz OF, Vaughn BV: Sleep complaints in patients with neuromuscular disorders. Sleep 22:S311, 1999. 50. Galano HR, Olby N, Howard JF, Shelton D: Feline myokymia and neuromyotonia. Journal of Veterinary Internal Medicine 18:408, 2004. 51. Weig SG, Wallace S, Howard JF, Bouldin TW, Malouf-Anderson N. An infant with hypotonia and abnormal electrophysiology. Journal of Child Neurology 21:263, 2006. 52. Weig SG, Howard JF, Zinn M: A 9-year old boy with Duchenne dystrophy and headache. Journal of Clinical Neuromuscular Disease 8:181; errata 8:241, 2007. 53. Weig SG, Fan, Z, Bouldin T, Howard JF, Malouf N, Thorne L: A 2 year old girl with motor delays and areflexia. Journal of Clinical Neuromuscular Disease 9:368, 2008. 54. Weig SG, Henderson FW, Wills-Gallagher J, Bhavaraju-Sanka RK, Howard JF, Thorne LB, Malouf N, Bouldin T. A 6 Year Old Boy with Autism and Painful Leg Weakness. Journal of Clinical Neuromuscular Disease 10:160-161, 2009. 55. Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Qiao C, Howard, JF, Xiao X. Widespread muscle expression of an aav-9 human mini-dystrophin construct after intravenous injection in golden retriever muscular dystrophy (grmd) neonatal dogs. Molecular Therapy 17:S152-153, 2009. 56. Howard JF, Fan Z, Kocis K, Valley R, Chopra C, Meyer DO, Delviscio T, Powers W, Muenzer J: Neuromuscular safety of saline transvenous limb perfusion in muscular dystrophy. Muscle & Nerve 42:669-670, 2010. 57. Fan Z, Kocis K, Valley R, Howard JF, Chopra M, An H, Lin W, Muenzer J, Powers W: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Neurology 76(Suppl 4): A451, 2011. 58. Parnell BA, Howard JF, Geller EJ: The Effect of Sacral Neuromodulation on Pudendal Nerve Function and Female Sexual Function. Female Pelvic Medicine & Reconstructive Surgery. 17(5, Suppl 1): 2011. 59. Howard JF, Barohn R,Cutter G, Freimer M, Juel, V; Mozaffar T, Mellion M, Benatar M, Farrugia M, Pulley M, Gorson K, Chaudry V, Pascuzzi R, Siddiqi Z, Kissel JT, and the MG Study Group: Randomized, double-blind, placebo-controlled, crossover, multicenter, Phase II study of eculizumab in patients with refractory generalized myasthenia gravis (gMG). Muscle & Nerve 44(4), 2011. 60. Bhavaraju-Sanka R, Kornegay JN, Bogan JR, Dow JI, Howard JF: Electrophysiological abnormalities of the Golden Retriever Muscular Dystorphy Model. Journal of Clinical Neuromuscular Disease 13(3):176-177, 2012. 61. Bhavaraju-Sanka R, Kornegay JN, Bogan JR, Dow JI, Howard JF: Single Fiber Electromyography in the Golden Retriever Muscular Dystorphy Model. Journal of Clinical Neuromuscular Disease 13(3):177, 2012. 62. Bhavaraju-Sanka R, Howard JF, Chahin NS: A case of asymmetric periscapular atrophy and weakness (Atypical McArdle’s Disease). Journal of Clinical Neuromuscular Disease 13(3):179- 180, 2012. 63. Sanders DB, Rosenfeld J, Dimachkie M, Meng L, Malik F, Tirasemtiv in Myasthenia Gravis Study Group (Howard JF): A Study to Evaluate Efficacy, Safety and Tolerability of Single Doses of Tirasemtiv in Patients with Myasthenia Gravis. Neurology 80(19): e201–e206, 2013, doi: 10.1212/WNL.0b013e3182924c84. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 42

64. Daniel Downs J, Howard JF Jr: Bilateral diffuse brachial plexopathy following sternum-sparing clamshell incision thoracotomies for double lung transplant. Muscle & Nerve 50(4):689, 2014. 65. Pasnoor M, He J, Herbelin L, He J, Dimachkie M, Nations S, Bril V, Wang A, Kissel J, Burns T, Saperstein D, Rosenfeld J, Shaibani A, Jackson C, Swenson A, Howard JF, Goyal N, Wicklund M, Miller J, Barohn, R, and the MSG Methotrexate Study MG Group: Phase II trial of methotrexate in myasthenia gravis. Neurology 82(Suppl S16.002, 2014. 66. Georgieva M, Wheeler S, Howard JF Jr: Cost-effectiveness of rituximab versus calcineurin inhibitors for refractory myasthenia gravis. Value In Health 18:A298, 2015. 67. Sanford T, Hill J, Harris M, Cockman M, Howard J: Correlation between ultrasound measures of the median nerve and electrodiagnostic severity of median mononeuropathy separated by gender. Muscle Nerve 52(S2):S13, 2015. 68. Jovanovich E, Howard JF Jr: Triple Nerve Palsy in a 6 Year Old Boy with 100% Displaced Proximal Humeral Metaphyseal Fracture. Muscle Nerve 52(S2):S78, 2015. 69. Guptill JT, Juel VC, Massey JM, Anderson, Yi, Howard JF Jr: Effect of Therapeutic Plasma Exchange on Immunoglobulins. Muscle Nerve 52(S2):S140, 2015. 70. Lin J, Park YA, Howard JF Jr, Mazepa M, Raval JS: Differentiating between Myasthenia Gravis patients who require acute vs. chronic therapeutic plasma exchange therapy. Journal of Clinical Apheresis. 31(2):109-110, 2016 71. Howard JF Jr, Utsugisawa K, Benatar M, et al. REGAIN: a randomized, double-blind, placebo-controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis. Journal of Neuromuscular Disease 3(Suppl 1): S5-S6, 2016.

BOOK REVIEWS 1. Howard JF: Review of Barna, B.P.: Laboratory Handbook of Neuroimmunologic Disease. Archives of Pathology & Laboratory Medicine 112:1167-1168, 1988. 2. Howard JF: Review of Ropper, A.H., E.F.M. Wijdicks, B.T. Truax: Guillain-Barré Syndrome. Journal of Epilepsy 5:69, 1992. 3. Howard JF: Review of Crues, J.V. (editor): MRI of the Musculoskeletal System (The Raven MRI Teaching File). Journal of Epilepsy 5:72, 1992. 4. Howard JF: Review of Liveson, J.A. Peripheral Neurology: Case Studies in Electrodiagnosis. Journal of Epilepsy 5:72, 1992.

PRESENTATIONS 1. Howard JF, S.L. Freedman: Morphology, incidence and luminal material of Wolffian ducts in the chicken (Gallus domesticus). Read at 84th Annual Meeting of the American Association of Anatomists, Philadelphia PA, April 1971. 2. Sanders DB, Howard JF, Johns TR: Single-fiber electromyography in myasthenia gravis. Read at 29th Annual Meeting of the American Academy of Neurology, Atlanta GA, April 1977. 3. Sanders DB, Howard JF, Johns TR: Single-fiber electromyography in myasthenia gravis. Read at 9th International Congress of Electroencephalography and Clinical Neurophysiology, Amsterdam Netherlands, September 1977. 4. Howard JF, Sanders DB: Passive transfer of human myasthenia gravis to rats: 1. Electrophysiology of the developing neuromuscular block. Read at 30th Annual Meeting of the American Academy of Neurology, Los Angeles CA, April 1978. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 43

5. Sanders DB, Howard JF, Johns TR, Campa JR: High-dose daily prednisone therapy in myasthenia gravis. Read at International Conference on Plasmapheresis and the Immunobiology of Myasthenia Gravis, San Francisco CA, June 1978. 6. Sanders DB, Howard JF: The role of plasmapheresis in the treatment of myasthenia gravis. Read at Haemonetics Research Institute Advanced Component Seminar, Boston MA, June 1978. 7. Howard JF, Sanders DB: Passive transfer of human myasthenia gravis to rats: An electrophysiologic study. Poster presented at IV International Congress on Neuromuscular Disease, Montreal Canada, September 1978. 8. Howard JF, Sanders DB: Plasma exchange therapy in the treatment of myasthenia gravis. Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York NY, December 1978. 9. Kim YI, Howard JF, Sanders DB: Depressant effects of morphine and meperidine on neuromuscular transmission in rat and human myasthenic muscles. Poster presented at 9th Annual Meeting of the Society for Neuroscience, Atlanta GA, November 1979. 10. Sanders DB, Howard JF, Johns TR: Plasma exchange experience at the University of Virginia. Read at the MDA Plasmapheresis Workshop, New York NY, April 1980. 11. Sanders DB, Howard JF: Single-fiber EMG in the diagnosis of myasthenia gravis. Read at the 2nd Single Fiber Electromyography Symposium, Athens Greece, May 1980. 12. Howard JF, Sanders DB: Serial single-fiber EMG studies in myasthenia patients treated with corticosteroids and plasma exchange therapy. Read at the 2nd Single Fiber Electromyography Symposium, Athens Greece, May 1980. 13. Sanders DB, Howard JF, Johns TR: Plasma exchange in the treatment of myasthenia gravis. Read at the MDA Scientific Session, Key Biscayne FL, June 1980. 14. Howard JF, Sanders DB, Kim YI, Johns TR, Muller WH: Intercostal muscle biopsy studies in myasthenia gravis: Clinical correlation and the direct effects of drugs and myasthenic serum. Read at the Conference on Myasthenia Gravis, The New York Academy of Sciences, New York, December 1980. 15. Quint SR, Howard JF: On-line analysis of neuromuscular bioelectric potentials. Read at the 34th Annual Conference on Engineering in Medicine and Biology, Houston TX, September 1981. 16. Howard JF, Johnson BR: Facilitatory effects of ethanol on neuromuscular transmission in intercostal muscle from patients with myasthenia gravis. Poster presented at the 11th Annual Meeting of the Society of Neuroscience, Los Angeles CA, October 1981. 17. Sanders DB, Howard JF: The use of serial jitter measurements in patients with myasthenia gravis. Poster presented at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York NY, December 1981. 18. Sanders DB, Howard JF: Serial studies in myasthenia gravis: The effects of treatment on jitter. Poster presented at the E.H. Lambert Symposium, Mayo Clinic, Rochester, April 1982. 19. Howard JF: Serial single-fiber EMG studies in myasthenia gravis. Read at the International Single-Fiber EMG Course and Symposium, Durham NC, April 1983. 20. Behlmer P, Howard JF, Silverman LM: CSF immunological differentiation of CNS sarcoidosis from multiple sclerosis. Poster presented at the 35th Annual Meeting of the American Academy of Neurology, San Diego CA, April 1983. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 44

21. Howard JF, Sanders DB: A comparison of the diagnostic sensitivity of single-fiber EMG and acetylcholine receptor antibody titer in myasthenia gravis. Poster presented at the 35th Annual Meeting of the American Academy of Neurology, San Diego CA, April 1983. 22. Martinkosky SJ, Howard JF, Finley CC, Quint SR: Pre and postplasmapheresis treatment measures obtained from myasthenic patients. Poster presented at the Annual American Speech-Language-Hearing Association Convention, Cincinnati OH, November 1983. 23. Massey JM, Sanders DB, Howard JF: Does single fiber EMG predict the course of ocular myasthenia? Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York NY, December 1983. 24. Quint SR, Greenwood RS, Howard JF, Gomez VJ: Automated data-acquisition and analysis of neural evoked potentials. Poster presented at the 37th Annual Conference on Engineering in Medicine and Biology, Los Angeles CA, September 1984. 25. Shy ME, Lange DJ, Howard JF, Gold AP, Lovelace RE, Penn AS: Quinidine exacerbating myasthenia gravis: a case report and intracellular recordings. Poster presented at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York NY, November 1984. 26. Massey J, Sanders DB, Howard JF: Single fiber EMG in ocular myasthenia gravis. Read at the 5th International Single Fiber EMG Symposium, Toronto Canada, June 1985. 27. Shy ME, Lange DJ, Howard JF, Gold AP, Lovelace RE, Penn AS: Quinidine exacerbating myasthenia gravis: a case report and intracellular recordings. Read at the 110th Annual Meeting of the American Neurological Association, Chicago IL, October 1985. 28. Massey JM, Sanders DB, Howard JF: Use of single fiber electromyography to predict the course of ocular myasthenia. Read at the 32nd Annual Meeting of the American Association of Electromyography and Electrodiagnosis, Las Vegas NV, October 1985. 29. Howard JF, Sanders DB, Massey JM, Bowman MH, Cook L: High dose intravenous gamma globulin treatment in myasthenia gravis: a preliminary report. Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York NY, December 1985. 30. Howard JF, Sanders DB: Pregnancy in myasthenia gravis: treatment and outcome. Poster presented at the Seventh International Conference on Myasthenia Gravis, New York NY, March 1986 31. Howard JF, Sanders DB, Johnson BR, Keagy BA: Effects of temperature on neuromuscular transmission in myasthenia gravis: studies of intracellular recordings in intercostal muscle biopsies. Poster presented at the Seventh International Conference on Myasthenia Gravis, New York NY, March 1986 32. Sanders DB, Howard JF, Olanow CW, Massey JM, Roses AD: Relationship of acetylcholine receptor antibody titer, single fiber EMG and clinical status in patients with myasthenia gravis. Poster presented at the Seventh International Conference on Myasthenia Gravis, New York NY, March 1986 33. Massey JM, Olanow CW, Howard JF, Sanders DB: Treatment of myasthenia gravis in the elderly. Poster presented at the Seventh International Conference on Myasthenia Gravis, New York NY, March 1986 34. Cook L, Howard JF, Folds JD: Immediate effects of IV IgG administration on peripheral blood B and T cells and PMNs in patients with myasthenia gravis. Poster presented at the 1986 FASEB Meeting, St. Louis MO, April 1986. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 45

35. Howard JF: Single-fiber EMG and intracellular recording, two methods to study neuromuscular transmission. Invited presentation read at the VI International Congress on Neuromuscular Diseases, Los Angeles CA, July 1986. 36. Howard JF, Cook L, Folds JD: Intravenous gamma globulin for the treatment of myasthenia gravis: clinical, electrophysiological and immunological correlations. Poster presented at the VI International Congress on Neuromuscular Diseases, Los Angeles CA, July 1986. 37. Armstrong RA, Toews AD, Howard JF, Morell P: Axonal transport of fucosylated glycoproteins in focally demyelinated sciatic nerve. Poster presented at the XXX Satellite Congress of the International Union of Physiological Sciences, on Axonal Transport, Calgary Canada, July 1986. 38. Massey JM, Sanders DB, Howard JF: The effect of cholinesterase inhibitors on single-fiber electromyography in myasthenia gravis. Poster presented at the 33rd Annual Meeting of the American Association of Electromyography and Electrodiagnosis, Boston, September 1986. 39. Howard JF: Single fiber EMG and myasthenia gravis. Invited presentation read at the VII International Single Fiber EMG Course, Chapel Hill NC, May 1987. 40. Howard JF: Comparison of Jitter Measurements made on Different EMG Equipment. Read at the Single Fiber EMG SIG Session of the 34th Annual Meeting of the American Association of Electromyography and Electrodiagnosis, San Antonio TX, October 1987. 41. Sanders DB, Howard JF, Massey JM, Mihovilovic M, Olanow CW, Roses AD, Stewart CR: Seronegative myasthenia gravis. Poster presented at the 112th Annual Meeting of the American Neurological Association, San Francisco CA, October 1987. 42. Howard JF: Current investigations and management of myasthenia gravis. Invited presentation read at the Annual Meeting of the North Carolina Neurological Society, Charlotte NC, November 1987. 43. Howard JF, Johnson BR: The effects of beta-adrenergic antagonists on neuromuscular transmission in rat skeletal muscle. Poster presented at the 17th Annual Meeting of the Society for Neuroscience, New Orleans LA, November 1987. 44. Hall CD, Howard JF, Donohue JF: Home ventilation with neuromuscular patients. The University of North Carolina experience. Read at the Foundation of Thanatology Symposium on Psychosocial Well-Being in Muscular Dystrophy and Allied Diseases III - Perspectives of the Future, New York, January 1988. 45. Nunez R, Howard JF: Selective reduction in miniature end-plate potential amplitude from rats with experimental autoimmune myasthenia gravis. Poster presented at the annual North Carolina Society for Neuroscience Meeting, Durham, NC, May 1988. 46. Leung P, Ostby S, Sakata R, Howard JF: Myasthenia gravis: Psychosocial aspects and rehabilitation. Poster presented at the annual meeting of the American Psychological Association, New Orleans LA, August 1988. 47. Sanders DB, Massey JM, Howard JF: 3,4-Diaminopyridine in myasthenia gravis and Lambert- Eaton syndrome. Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, New York, December 1988. 48. Royal ME, Howard JF: Muller's muscle injury with ptosis mimicking myasthenia gravis. Poster presented at the 41st Annual Meeting of the American Academy of Neurology, Chicago IL, April 1989. 49. Sanders DB, Massey JM, Howard JF: 3,4-Diaminopyridine in myasthenia gravis and Lambert- Eaton syndrome. Read at the 41st Annual Meeting of the American Academy of Neurology, Chicago IL, April 1989. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 46

50. Howard JF, Campbell WW: Thymic cyst and myasthenia gravis: mistaken identity for thymoma. Poster presented at the 42nd Annual Meeting of the American Academy of Neurology, Miami FL, May 1990. 51. Cheshire WP, Santos CS, Howard JF, Massey EW: Spinal cord infarction - etiology and outcome. Poster presented at the 42nd Annual Meeting of the American Academy of Neurology, Miami, May 1990. 52. Massey JM, Sanders DB, Howard JF: Sensitivity of diagnostic tests in myasthenia gravis. Poster presented at the 42nd Annual Meeting of the American Academy of Neurology, Miami FL, May 1990. 53. Hopkins AL, Howard JF, Stewart CR, Wheeler SJ, Kornegay JN: Stimulated single fiber electromyography in normal dogs. Read at the Annual Meeting of the American College of Veterinary Internal Medicine, New Orleans LA, May 1991. 54. Dvergtsen CL, Meeker RB, Howard JF: Down regulation of muscarinic receptors in rats due to early post natal exposure to parathion. Poster presented at the 21st Annual Meeting of the Society for Neuroscience, New Orleans LA, November 1991. 55. Andrews PI, Massey JM, Howard JF, Sanders DB: Sex and pubertal stage at disease onset influence antibody status and disease severity in juvenile myasthenia gravis. Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington DC, April 1992. 56. Massey JM, Sanders DB, Howard JF: Observations on 80 patients with thymoma and myasthenia gravis (MG). Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington DC, April 1992. 57. Sanders DB, Howard JF: A multi-center myasthenia gravis database system. Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington DC, April 1992. 58. Sanders DB, Howard JF, Massey JM: Demographic observations on 860 patients with acquired myasthenia gravis (MG). Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington DC, April 1992. 59. Sanders DB, Howard JF, Massey JM: 3,4-Diaminopyridine (DAP) in Lambert-Eaton myasthenic syndrome and myasthenia gravis (MG). Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington, April 1992. 60. Sanders DB, Howard JF, Massey JM: Acetylcholine receptor antibody determinations in 724 patients with acquired myasthenia gravis (MG). Poster presented at the International Conference on Myasthenia Gravis and Related Disorders, Washington DC, April 1992. 61. Whitsell DL, Weissler MC, Donovan MK, Howard JF, Martinkosky SJ: Measurement of laryngeal resistance in the evaluation of botulinum toxin injection for treatment of spastic dysphonia. Read at the 3rd International Conference on Head and Neck Cancer, San Francisco CA, July 1992. 62. Jaradeh SS, D'Cruz OF, Howard JF, Haberkamp TJ, Konkol RJ: Möbius syndrome: Electrophysiological studies in six cases. Read at the 39th Annual Meeting of the American Association of Electrodiagnostic Medicine, Charleston, October 1992. 63. Howard JF, Weiss AS, Donovan MK, Cheshire WP, Braun TG: 3,4-Diaminopyridine effects on compound muscle action potential amplitudes in a patient with botulism. Poster presented at the 39th Annual Meeting of the American Association of Electrodiagnostic Medicine, Charleston SC, October 1992. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 47

64. Donovan MK, Weissler, Martinkosky SJ, Howard JF: Serial single fiber EMG studies in patients with focal laryngeal dystonia following botulinum A toxin injections. Poster presented at the 117th Annual Meeting of the American Neurological Association, Toronto Canada, October 1992. 65. Howard JF, Donovan MK, Tucker MS: Urinary incontinence in myasthenia gravis: A single fiber EMG study. Poster presented at the 117th Annual Meeting of the American Neurological Association, Toronto Canada, October 1992. 66. Martinkosky SJ, Whitsell DL, Weissler MC, Howard JF, Donovan MK: Longitudinal measurement of laryngeal resistance before and after BOTOX injections. Read at the American Speech-Language-Hearing Association Annual Meeting, San Antonio TX, November 1992. 67. Howard JF, Donovan MK, Weissler MC, Whitsell DL, Martinkosky SJ: Botulinum toxin injection for adductor laryngeal dystonia (spasmodic dysphonia). Read at the North Carolina Neurological Society Meeting, Charlotte NC, November 1993. 68. Howard JF: Complications of botulinum toxin therapy. Read at the North Carolina Neurological Society Meeting, Charlotte NC, November 1993. 69. Andrews PI, Massey JM, Howard JF, Sanders DB: Demographic influences upon response to therapy and outcome in juvenile myasthenia gravis (JMG). Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, Chicago IL, December 1993. 70. Andrews PI, Massey JM, Howard JF, Sanders DB: Race, sex and puberty influence disease onset, disease severity and antibody levels in juvenile myasthenia gravis (JMG). Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, Chicago IL, December 1993. 71. Andrews PI, Massey JM, Howard JF, Sanders DB: Seronegative myasthenia gravis: insights from demographic analysis. Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, Chicago IL, December 1993. 72. Martinkosky SJ, Whitsell DL, Weissler MC, Howard JF, Donovan MK: Longitudinal measurement of laryngeal resistance before and after BOTOX injections. Read at the North Carolina Speech, Hearing and Language Association 40th Annual Meeting, Asheville NC, April 1994. 73. Finkel AG, Howard JF, Mann JD: Successful treatment of headache related to intravenous immunoglobulin (IVIG) with antimigraine medications: a case report. Poster presented at the 46th Annual Meeting of the American Academy of Neurology, Washington DC, May 1994. 74. Finkel AG, Howard JF, Mann JD: Headache related to intravenous immunoglobulin (IVIG): A case report and literature review. Poster presented at the Annual Meeting of the International Headache Society, Toronto, September 1995. 75. Howard JF: Electronic Mail. Read at the Computerization and Modeling in Electrodiagnostic Medicine SIG Session of the 42nd Annual Meeting of the American Association of Electrodiagnostic Medicine, Montréal Canada, September 1995. 76. Sanders DB, Howard JF, Massey JM: Single fiber EMG (SFEMG) in myasthenia gravis (MG). Read at the Xth International Congress of EMG and Clinical Neurophysiology (X-ICEMGCN), Kyoto Japan, October 1995. 77. Scott WW, Detterbeck FC, Howard JF, Egan TM, Keagy BA, Starek PJK, Wilcox BR: One hundred consecutive thymectomies. Read at the Southern Thoracic Surgery Association Meeting, San Antonio, November 1995 Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 48

78. Sanders DB, Andrews PI, Howard JF, Massey JM: Seronegative myasthenia gravis. Read at Symposium on Advances in the Diagnosis, Pathogenesis, and Treatment of Myasthenia Gravis, New York NY, April 1996. 79. Navaneethan D, Penn AS, Howard JF, Conti-Fine BM: Expression of the (α7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic thymuses. Read at the 2nd World Congress of Cellular and Molecular Biology, Ottawa Canada, September 1996. 80. Sanders DB, Andrews PI, Howard JF Jr, Massey JM: Influence of age and gender on the incidence of seronegative (SN) and seropositive (SP) myasthenia gravis (MG). Read at the Annual Scientific Session of the Myasthenia Gravis Foundation, Miami FL, October 1996. 81. Husain AM, Massey JM, Howard JF Jr, Sanders DB: Acetylcholine receptor antibody measurements in acquired myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica CA, May 1997. 82. Wang Z-W, Okita DK, Howard JF Jr, Conti-Fine BM: Th1 epitope repertoire on the α subunit of human muscle acetylcholine receptor in myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica CA, May 1997. 83. Wang Z-W, Okita DK, Howard JF Jr, Conti-Fine BM: CD4+ T cell recognition of the εsubunit of human muscle acetylcholine receptor in myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica CA, May 1997. 84. Wang Z-W, Okita DK, Howard JF Jr, Conti-Fine BM: of human muscle acetylcholine receptor subunits in generalized and ocular myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica, May 1997. 85. Raju R., Navaneetham D, Protti MP, Horton RM, Hoppe B, Howard JF Jr, Conti-Fine BM: TCR Vß usage by acetylcholine receptors specific CD4+ T cells in myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica CA, May 1997. 86. Diethelm-Okita B, Wells G, Kuryatov A, Okita D, Howard JF Jr, Lindstrom J, Conti-Fine BM: Biosynthetic and synthetic AChR sequences to study T cells in myasthenia gravis. Poster presented at the IXth International Conference on Myasthenia Gravis and Related Disorders. Santa Monica, May 1997. 87. Wang Z-W, Okita DK, Howard JF Jr, Conti-Fine BM: CD4+ cells in myasthenia gravis recognize the ε subunit of human muscle acetylcholine receptor. Paper read at the International Myasthenia Gravis Workshop. Mysore, India, November 1998. 88. Wang Z-W, Karachunski PI, Howard JF Jr, Conti-Fine BM: Myasthenia in SCID mice engrafted with blood lymphocytes from myasthenia gravis patients. Role of CD4+ and CD8+ cells. Paper read at the International Myasthenia Gravis Workshop. Mysore, India, November 1998. 89. Owen HG, Brecher ME, Howard JF Jr, Bandarenko N: Minimizing hypovolemic reactions with 3% hetastarch replacement during therapeutic plasma exchange. Paper read at the 20th Annual Meeting of the American Society for Apheresis. April 1999. 90. York JA, Howard JF Jr, Braun TG, Hall CD, D’Cruz OF, Vaughn BV: Sleep complaints in patients with neuromuscular disorders. Poster presented at the Annual Meeting of the APSS, Orlando FL, June 1999. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 49

91. Mareska MC, Adams KK, Muenzer J, Braun TG, Howard JF Jr: Late onset presentation of glutaric acidemia type II with myopathy. Poster presented at the 48th Annual Scientific Session of the American Association of Electrodiagnostic Medicine. October 2001. 92. Biehn SE, Robertson KR, Johnson KM, Howard JF Jr: The prevalence of depression in myasthenia gravis. Paper read at the Annual Scientific Session of the Myasthenia Gravis Foundation, San Francisco CA, October, 2003. 93. Galano HR, Olby N, Howard JF Jr, Shelton D: Feline myokymia and neuromyotonia. Paper read at the 22nd Annual American College of Veterinary Internal Medicine Forum, Minneapolis MN, June 2004. 94. Biehn SE, Robertson KR, Johnson KM, Howard JF Jr: The prevalence of depression in myasthenia gravis. An internet presentation to MGnet, the Internet Chapter of the Myasthenia Gravis Foundation, November 19, 2005. 95. Weig S, Wallace S, Howard JF Jr, Bouldin T, Malouf-Anderson N: An infant with hypotonia and abnormal neurophysiology. Poster presented at the 28th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2006. 96. Howard JF Jr: Urinary incontinence in myasthenia gravis: A single fiber EMG case study. Presented at the Single Fiber EMG Special Interest Group at the 53rd Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Washington, DC, October 2006. 97. Zinn M, Weig SG, Howard JF Jr: A 9-year old boy with Duchenne muscular dystrophy and headache. Poster presented at The 29th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2007. 98. Siddiqi ZA, Howard JF Jr: Single-Fiber EMG of the Frontalis and Orbicularis Oculi Muscles in Myasthenia Gravis: A Comparative Study. Poster presented at the 11th International Conference on Myasthenia Gravis and Related Disorders, Chicago, IL, May 2007. 99. Kupersmith M, Kaminski H, Maguire M, Barohn R, Howard J, Sanders D: Ocular MG prednisone treatment trial. Paper read at the 11th International Conference on Myasthenia Gravis and Related Disorders, Chicago, IL, May 2007. 100. Howard JF Jr: Myasthenia Gravis 101: Past, Present and Future. Paper read at the Annual Meeting of the Myasthenia Gravis Association of Barbados, Bridgetown Barbados, May 2007. 101. Howard JF Jr: The neurotoxicology of neuromuscular transmission. Paper read at the Critical Care Special Interest Group at the 54th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Phoenix AZ, October 2007. 102. Weig SG, Fan, Z, Bouldin T, Howard JF Jr, Malouf N, Thorne L: A 2 year old girl with motor delays and areflexia. Paper read at the 30th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2008. 103. Howard JF Jr. The role of complement in Myasthenia Gravis. Paper read at the US Eculizumab Investigator meeting, New York NY, June 2008. 104. Weig SG, Henderson FW, Wills-Gallagher J, Bhavaraju-Sanka RK, Howard JF Jr, Thorne LB, Malouf N, Bouldin TW. A 6 Year Old Boy with Autism and Leg Pain. Paper read at the 31st Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2009. 105. Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Qiao C, Howard JF Jr, Xiao X. Widespread muscle expression of an aav-9 human mini-dystrophin construct after intravenous injection in golden retriever muscular dystrophy (grmd) neonatal dogs. Paper read at the 12th Annual Meeting of the American Society of Gene Therapy. San Diego CA, May 2009. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 50

106. Sanders DB, Howard JF Jr, Burns T (moderator): Collaborations and Consortia - Critical for Research in Rare Diseases. A podcast presented at the Annual Meeting of the National Myasthenia Gravis Foundation of America. Charlotte NC, May 2009. 107. Howard JF Jr. Physiological and Molecular Aspects of the Neuromuscular Junction and Synaptic Transmission. Paper read at the Xth Quantitative EMG Conference, Venice Italy, May 2009. 108. Siddiqi ZA, Howard JF Jr. SFEMG in “mild” MG: A comparative study of the orbicularis oculi and frontalis muscles. Paper read at the Xth Quantitative EMG Conference, Venice Italy, May 2009. 109. Howard JF Jr. Iatrogenic disorders of neuromuscular transmission. Paper read at the Course on Iatrogenic Neuromuscular Disorders at the 56th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, San Diego Ca, October 2009. 110. Howard JF Jr. The role of complement in Myasthenia Gravis. Paper read at the UK Eculizumab Investigator meeting, London England, January 2010. 111. Powers W, Fan Z, Kocis K, Valley R, Chopra C, Howard J, Muenzer J: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Paper read at the 13th Annual Meeting of the American Society of Gene and Cell Therapy, Washington DC, May 21, 2010. 112. Howard JF Jr, Powers W, Fan Z, Kocis K, Valley R, Chopra C, Muenzer J: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Paper read at the Duchenne Therapeutic Development Meeting of the Xth Annual PPMD Connect Conference, Denver CO, June 25, 2010. 113. Howard JF Jr, Powers W, Fan Z, Kocis K, Valley R, Chopra C, Meyer DO, Delviscio T, Muenzer J: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Poster presented at the annual Muscle Study Group meeting, Java Center NY, September 20, 2010. 114. Howard JF Jr, Fan Z, Kocis K, Valley R, Chopra M, Meyer DO, Delviscio T, Powers W, Muenzer J: Neuromuscular safety of saline transvenous limb perfusion in muscular dystrophy. Poster presented at the 57th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Quebec City, Ontario, Canada, October 9, 2010. 115. Howard JF Jr: Lessons being learned from the eculizumab study. Paper read at the Myasthenia Gravis Clinical Trial Consensus Conference, Durham, NC, November 19, 2010. 116. Howard JF Jr, Fan Z, Kocis K, Valley R, Chopra M, An H, Powers W, Muenzer J: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Poster presented at the MDA Scientific Meeting, Las Vegas NV, March 14, 2011. 117. Fan Z, Kocis K, Valley R, Howard JF Jr, Chopra M, An H, Lin W, Muenzer J, Powers W: Safety and feasibility of transvenous limb perfusion with saline in human muscular dystrophy. Paper read at the 63rd Annual Meeting of the American Academy of Neurology, Honolulu, HI, April 2011. 118. Parnell BA, Howard JF Jr, Geller EJ: The Effect of Sacral Neuromodulation on Pudendal Nerve Function and Female Sexual Function. Poster to be presented at the 32nd Annual Scientific Meeting AUGS, Providence, RI, September 2011. 119. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Single Fiber electromyography in the golden retriever muscular dystrophy model. Poster presented at the 58th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, San Francisco CA, September 2011. 120. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Electrophysiological abnormalities of the golden retriever muscular dystrophy model. Poster presented at the 58th Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 51

Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, San Francisco CA, September 2011. 121. Howard JF Jr; Barohn R; Cutter G; Freimer M; Juel V; Mozaffar T; Mellion M; Benatar M; Farrugia M; Pulley M; Gorson K; Chaudry V; Pascuzzi R; Siddiqi Z; Kissel JT; and the MG Study Group. Randomized, double-blind, placebo-controlled, crossover, multicenter, phase II study of eculizumab in patients with refractory generalized myasthenia gravis (Protocol C08-001). Paper read at the 58th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, San Francisco CA, September 2011. 122. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Single Fiber electromyography in the golden retriever muscular dystrophy model. Poster presented at the 34th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2012. 123. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Electrophysiological abnormalities of the golden retriever muscular dystrophy model. Poster presented at the 34th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2012. 124. Bhavaraju-Sanka RK, Chahin N, Howard JF Jr: A case of asymmetrical periscapular atrophy and winging. Paper read at the 34th Carrell-Krusen Symposium, Texas Scottish Rite Hospital for Children, Dallas TX, February 2012. 125. Howard JF Jr; Barohn R; Cutter G; Freimer M; Juel V; Mozaffar T; Mellion M; Benatar M; Farrugia M; Kissel JT; and the MG Study Group. Randomized, double-blind, placebo-controlled, crossover, multicenter, phase II study of eculizumab in patients with refractory generalized myasthenia gravis Paper to be read at the 64th Annual Meeting of the American Academy of Neurology, New Orleans, LA, April 2012. 126. Howard JF Jr; Barohn R; Cutter G; Freimer M; Juel V; Mozaffar T; Mellion M; Benatar M; Farrugia M; Kissel JT; and the MG Study Group. Randomized, double-blind, placebo-controlled, crossover, multicenter, phase II study of eculizumab in patients with refractory generalized myasthenia gravis Invited presentation read at the 12th International Conference on Myasthenia Gravis and Related Disorders, New York, NY, May 2012. 127. Drachman DB, Traynor BJ, Renton AE, Abramzon Y, Nalls MA and the Myasthenia GWAS Collaborative Group (Howard JF Jr). Genome-Wide Association Study of Myasthenia Gravis. Paper read at the 12th International Conference on Myasthenia Gravis and Related Disorders, New York, NY, May 2012. 128. Barohn RJ, Pasnoor M, Herbelin L, Dimachkie M and the Methotrexate MG Study Group (Howard JF Jr). Phase II Trial of Methotrexate in Myasthenia Gravis. Paper read at the 12th International Conference on Myasthenia Gravis and Related Disorders, New York, NY, May 2012. 129. Scola MR, Caughey MC, Meyer DO, Emmett R, Howard JF Jr, Gallippi CM: ViSR ultrasound assessment of viscoelastic properties of human Duchenne muscular dystrophy, in vivo. Poster presented at the 2012 IEEE International Ultrasonics Symposium, Dresden Germany, October 2012. 130. Sanders DB, Rosenfeld J, Dimachkie M, Meng L, Malik F, Tirasemtiv in Myasthenia Gravis Study Group (Howard JF Jr): A Study to Evaluate Efficacy, Safety and Tolerability of Single Doses of Tirasemtiv in Patients with Myasthenia Gravis. Poster presented at the 65th Annual Meeting of the American Academy of Neurology, San Diego, CA. March 18, 2013. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 52

131. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Motor unit potential abnormalities of the golden retriever muscular dystrophy model. Poster presented at the 2013 MDA Scientific Conference, Washington DC, April 2013. 132. Bhavaraju-Sanka RK, Kornegay JN, Bogan JR, Dow JL, Howard JF Jr: Single Fiber electromyography in the golden retriever muscular dystrophy model. Poster presented at the 2013 MDA Scientific Conference, Washington DC, April 2013. 133. Scola MR, Caughey MC, Meyer DO, Emmett R, Howard JF Jr, Chopra M, Gallippi CM: In Vivo Dystrophic Degeneration Quantified in Individual Muscles of Boys with Duchenne Muscular Dystrophy Using Serial ViSR Ultrasound. Poster presented at the 2013 MDA Scientific Conference; Washington, DC, April 2013. 134. Scola MR, Kornegay JN, Howard JF Jr, Gallippi CM: ViSR Discrimination of Viscoelastic Changes in Dystrophic Muscle, In Vivo. Paper read at the International Symposium on Ultrasonic Imaging and Tissue Characterization; Arlington, VA., June 2013. 135. Scola MR, Kornegay JN, Howard JF Jr, Nichols TC, Gallippi CM: Viscoelastic Strain Response (ViSR) Ultrasound in Pre-Clinical and Clinical Application. Invited Presentation to be given at the ASME 2013 International Mechanical Engineering Congress & Exposition, San Diego, CA, November 2013. 136. Howard JF Jr: The role of complement in Myasthenia Gravis and Phase 2 Eculizumab Results in MG. Paper read at the US & South America Eculizumab Investigator meeting, Atlanta, January 30, 2014. 137. Howard JF Jr: The role of complement in Myasthenia Gravis and Phase 2 Eculizumab Results in MG. Paper read at the European & Australian Eculizumab Investigator meeting, Budapest, Hungary, March 14, 2014. 138. Pasnoor M, He J, Herbelin L, He J, Dimachkie M, Nations S, Bril V, Wang A, Kissel J, Burns T, Saperstein D, Rosenfeld J, Shaibani A, Jackson C, Swenson A, Howard JF, Goyal N, Wicklund M, Miller J, Barohn, R, and the MSG Methotrexate Study MG Group: Phase II trial of methotrexate in myasthenia gravis. Paper read at the annual meeting of the American Academy of Neurology, Philadelphia, PA, April 2014. 139. Howard JF Jr: Miastenia Gravis Refractaria: Nuevos Enfoques Terapeuticos. Paper read at Simposio de Neuroinmunologia, FLENI, Sede Belgrano, Buenos Aires, Argentina, August 1-2, 2014. 140. Juel VC, Sanders DB, Hobson-Webb LD, Massey JM, Guptill JT, O’Brien F, Wang JJ, Howard JF Jr: Parallel clinical and jitter changes during rapid, eculizumab-induced myasthenic remission. Paper read at the Annual Scientific Session of the Myasthenia Gravis Association held in association with the 61st Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Savannah, GA, November 1, 2014. 141. Barohn RJ, Pasnoor M, Herbelin L, Dimachkie M and the Methotrexate MG Study Group (Howard JF Jr): Phase II Trial of Methotrexate in Myasthenia Gravis. Paper read at the Annual Scientific Session of the Myasthenia Gravis Association held in association with the 61st Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Savannah, GA, November 1, 2014. 142. James L, Howard JF Jr: Bilateral Hand Pain in a Patient with Bifid Median Nerves and Persistent Median Arteries in Both Wrists: A Case Report. Poster presented at the 31st Annual Meeting of the American Academy of Pain Medicine, National Harbor, MD, March 19-22, 2015. 143. Georgieva MV, Wheeler SB, Howard JF Jr: Cost Effectiveness of Rituximab vs. Calcineurin Inhibitors for Refractory Myasthenia Gravis. Poster presented at the International Society for Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 53

Pharmacoeconomics and Outcomes Research (ISPOR) 20th Annual International Meeting, Philadelphia, PA, May 20, 2015. 144. Georgieva MV, Wheeler SB, Howard JF Jr: Cost Effectiveness of Rituximab vs. Calcineurin Inhibitors for Refractory Myasthenia Gravis. Poster to be presented at the 2015 Annual Academy Health Research Meeting, Minneapolis, June 15, 2015. 145. Wang JJ, Barohn RJ, Burns TM, Kissel JT, O’Brien F, Howard JF Jr: A Randomized, Double-Blind, Placebo-Controlled, Phase 3, Multi-Center Study To Evaluate the Safety and Efficacy of Eculizumab in Subjects With Refractory Generalized Myasthenia Gravis: REGAIN. Poster presented at the 2015 Annual Muscle Study Group Society Meeting, Snowbird, Utah, October 19-21, 2015. 146. Sanford TS, Hill JJ, Harris MG, Cockman M, Howard JF Jr: Correlation between ultrasound measures of the median nerve and electrodiagnostic severity of median mononeuropathy separated by gender. Paper (Golseth Young Investigator Award) read at the 62nd Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Honolulu, Hawaii, October 28, 2015. 147. Guptill JT, Juel VC, Massey JM, Anderson, Yi, Howard JF Jr: Effect of Therapeutic Plasma Exchange on Immunoglobulins. Paper read at the Annual Scientific Session of the Myasthenia Gravis Association held in association with the 62nd Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Honolulu, HI, October 28, 2015. 148. Jovanovich E, Howard JF Jr: Triple Nerve Palsy in 6 Year Old Boy with 100% Displaced Proximal Humeral Metaphyseal Fracture. Poster presented at the at the 62nd Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Honolulu, Hawaii, October 31, 2015. 149. Jovanovich E, Henley A, Howard JF Jr, Chopra M, Dawson J, Karam C: No Strong Evidence for ALS Clusters in North Carolina. Poster presented at the 14th Annual NEALS Meeting, Clearwater, FL, November 5, 2015. 150. Guptill JT, Juel VC, Massey JM, Chopra M, Howard JF Jr: Effect of Therapeutic Plasma Exchange on Myasthenic Outcome Measures. Poster presented at the at the 68th Annual Meeting of the American Academy of Neurology, Vancouver, BC, Canada, April 18, 2016. 151. Soim A, Lamb M, Campbell K, Pandya S, Peay HL, Howard, JF Jr, Fox D and the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet): A cross-sectional study of school experiences of boys with Duchenne and Becker muscular dystrophy. Poster to be presented at the Annual 2016 Parent Project MD (PPMD) Connect Conference, Orlando, FL, June 26-29, 2016. 152. Howard JF Jr, Utsugisawa K, Benatar M, et al. REGAIN: a randomized, double-blind, placebo- controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis. Paper read at the ICNMD 2016 meeting; Toronto, Canada, July 7, 2016. 153. Howard JF Jr, Utsugisawa K, Benatar M, et al. REGAIN: a randomized, double-blind, placebo- controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis. Paper read at the Myasthenia Gravis Annual Scientific Session, New Orleans, LA, September 14, 2016. 154. Howard JF Jr, Utsugisawa K, Benatar M, et al. REGAIN: a randomized, double-blind, placebo- controlled, multi-center phase 3 study of the safety and efficacy of Eculizumab in subjects with refractory generalized myasthenia gravis. Paper read at the 2016 Muscle Study Group meeting Snowbird, UT; September 25, 2016. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 54

155. Howard JF Jr: Myasthenia Gravis; An Overview. Paper read at the Argenx Investigatory meeting, Amsterdam, Netherlands, December 3, 2016. 156. Howard JF Jr: Myasthenia Gravis; 2016 and Beyond. Paper read at the Argenx Pharmaceuticals seminar, Ghent, Belgium, December 5, 2016. 157. Richards J, Howard JF Jr: Seronegative myasthenia gravis associated with malignant thymoma. Poster presented at the Annual North Carolina Neurological Society Meeting. Pinehurst, NC, February 18, 2017 (1st Prize, Resident and Fellow poster). 158. Howard JF Jr, O’Brien F, Wang JJ, Mantegazza R, and the REGAIN Study Group: Dual Responder Analyses of Both Muscle Strength and Activities of Daily Living, Eculizumab Versus Placebo, in Refractory Generalized Myasthenia Gravis (gMG) Patients: Results from the REGAIN Study. Paper to be read and Poster presented at the 69th Annual Meeting of the American Academy of Neurology, Boston, MA, April 25, 2017. 159. Howard JF Jr, O’Brien F, Wang JJ, Mantegazza R, and the REGAIN Study Group: Eculizumab Results in Improvement in Activities of Daily Living and Muscle Strength in Refractory Generalized Myasthenia Gravis Patients Compared with Placebo. Paper read at the 13th International Conference on Myasthenia Gravis and Related Disorders. New York, NY, May 16, 2017. 160. Benatar M, Howard JF Jr, Barohn R, Wolfe G: Learning from the Past: Reflections on Recently Completed MG Trials. Paper read at the 13th International Conference on Myasthenia Gravis and Related Disorders. New York, NY, May 16, 2017. 161. Raval JS, Killian R. Drake CE, Howard JF Jr, Park YA: Association of Total Serum Immunoglobulin G (IgG) Concentrations During Therapeutic Plasma Exchange (TPE) Therapy and Myasthenia Gravis (MG) Persistence. Poster presented at the 13th International Conference on Myasthenia Gravis and Related Disorders. New York, NY, May 15-17, 2017. 162. Hehir MK, Hobson-Webb LD, Benatar M, Barnett Tapia C, Silvestri NJ, Howard JF Jr, Howard D, Visser A, Crum BA, Nowak R, Beekman R, Kumar A, Ruzhansky K, Chen I-HA, LaBoy SM, Pulley M, Fellman MA, Greene S, Pasnoor M, Burns TM: Rituximab is Effective Treatment of Anti- MuSK Myasthenia Gravis: Multi-Center Case Control Study. Paper read at the 13th International Conference on Myasthenia Gravis and Related Disorders. New York, NY, May 16, 2017. 163. Lewis L, Howard JF Jr, Olby N: Electrophysiologic quantification of motor neuron pool excitability in chronically paralyzed dogs and association with gait. Paper to be read at the 2017 ACVIM (American College of Veterinary Internal Medicine) Forum New Harbor, MD, June 8-10, 2017. 164. Vissing J, Zhang J, Derosier F, Wang JJ, Howard JF Jr: Correlations of Assessments of Activities of Daily Living and Muscle Strength in Refractory Myasthenia Gravis in the REGAIN Study. ePresentation at the 3rd EAN Congress, Amsterdam, June 24-27, 2017. 165. Jacob S, Evoli A, Boscoe A, Zhang J, Howard JF Jr: Patients with Refractory Myasthenia Gravis are at Increased Risk for Myasthenic Crises, Disease Exacerbation, Intensive Care Unit Visits, and Hospitalizations. ePresentation at the 3rd EAN Congress, Amsterdam, June 24-27, 2017. 166. Andersen H, Mantegazza R, Derosier F, Wang JJ, Howard JF Jr: Correlation of Neuro-QOL With MG-ADL, QMG, and MG-QOL15 in Assessing the Spectrum of Disease in Patients With Refractory Generalised Myasthenia Gravis in the REGAIN Study. ePresentation at the 3rd EAN Congress, Amsterdam, June 24-27, 2017. 167. Andersen H, Mantegazza R, Derosier F, Wang JJ, Howard JF Jr: Eculizumab Improves Fatigue in Patients With Refractory Generalized Myasthenia Gravis in the REGAIN Study. ePresentation at the 3rd EAN Congress, Amsterdam, June 24-27, 2017. Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 55

168. Howard JF Jr, Wang JJ, O’Brien F, Fujita K, Mantegazza R, Regain Study Group: Efficacy of eculizumab is sustained over 52 weeks in patients with AChR+ refractory generalized myasthenia gravis: interim results from the open-label extension of REGAIN. Paper to be read at the Annual Scientific Session of the Myasthenia Gravis Foundation of America in conjunction with the 64th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Phoenix, AZ, September 13, 2017. 169. Howard JF Jr, Wang JJ, O’Brien F, Fujita K, Mantegazza R, Regain Study Group: Efficacy of eculizumab on myasthenia gravis-activities of daily living and its bulbar, respiratory, limb and ocular domains in patients with AChR+ refractory generalized myasthenia gravis. Poster presented at the 64th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Phoenix, AZ, September 13-15, 2017. 170. Howard JF Jr, Wang JJ, O’Brien F, Fujita K, Mantegazza R, Regain Study Group: Efficacy of eculizumab is maintained beyond 26 weeks in patients with AChR+ refractory generalized myasthenia gravis. Poster presented at the 64th Annual Meeting of the American Association of Neuromuscular and Electrodiagnostic Medicine, Phoenix, AZ, September 13-15, 2017. 171. Utsugisawa K, Howard JF Jr, Wang JJ, O’Brien F, Murai H, Regain Study Group: Long-term efficacy of eculizumab on the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale and its respiratory, bulbar, limb and ocular domains in patients with AChR+ refractory generalized myasthenia gravis. Paper read at the 29th Annual Meeting of the Japanese Society for Neuroimmunology, Sapporo, Japan, October 6, 2017. 172. Murai H, Howard JF Jr, Wang JJ, O’Brien F, Utsugisawa K, Regain Study Group: Efficacy of eculizumab is maintained beyond 26 weeks in patients with AChR+ refractory generalized myasthenia gravis (gMG). Paper read at the 29th Annual Meeting of the Japanese Society for Neuroimmunology, Sapporo, Japan, October 6, 2017.

PUBLIC MEDIA • Discovery Health Channel, Segment on Myasthenia Gravis, 2005.

SPECIAL HONORS AND AWARDS: • Special Honors, Anatomy, University of Vermont, 1970 • Lamb Fellowship Award, University of Vermont, 1974 • H.L. Martin Award in Neurology, University of Vermont, 1974 • UNC Junior Faculty Development Award, 1982 • Jefferson-Pilot Academic Fellowship Award in Medicine, 1984 • NIH Teacher-Investigator Development Award, 1985 • Myasthenia Gravis Foundation of America, Certificate of Appreciation for Outstanding Service, 1994, 1997 • Carolinas Chapter of the Myasthenia Gravis Foundation of America, Certificate of Appreciation for Outstanding Service, 1995 • Myasthenia Gravis Foundation of America, Doctor of the Year Award, 1997 • UNC Whitehead Medical Society Freshman Basic Science Course Award (course faculty member), 2001 — 2004 • Endowed Chair (Broyhill Foundation), James F. Howard Distinguished Professor of Neuromuscular Disease, 2003 • UNC Department of Neurology, Faculty Teaching Award, 2004-2005 • Myasthenia Gravis Foundation of America, Public Service Award, 2006 Curriculum Vitae November 6, 2017 Howard, James F., Jr. Page 56

• UNC Department of Physical Medicine & Rehabilitation, Resident Faculty Teaching Award, 2006-2007 • American Urogynecological Society Foundation Frank Benson Award Grant (Brent Parnell, MD PI), 2009 • American Association of Neuromuscular and Electrodiagnostic Medicine Distinguished Physician Award, 2015 • UNC Health Care and Faculty Physicians Award for Carolina Care Excellence, 2015, 2016, 2017