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Spring-2020-Abstract.Pdf STUDENT SCHOLAR SYMPOSIUM SPRING 2020 TUESDAY, MAY 5 AND WEDNESDAY, MAY 6 SPRING SESSION ABSTRACT VOLUME Message from the Director Greetings and welcome to the Spring 2020 Chapman University Student Scholar Symposium! Student Scholar Symposium celebrates the remarkable scholarship and creativity conducted by Chapman students. Student Scholar Symposium is sponsored by the Center for Undergraduate Excellence, which is the first stop and the central hub for students to learn about and engage in undergraduate research and creativity activity; and to discover the wide range of prestigious external scholarships available. Our student presenters reflect the diversity of academic and creative disciplines thriving within the Chapman community. This year we have moved the Spring Student Scholar Symposium to this virtual platform where you can attend a live Microsoft Teams meeting to connect with the student and discuss their research/creative activity. The virtual symposium allows our students multiple ways to showcase their research and creative project, consisting of posters, oral, visual arts, performing arts, and film and media presentations. Our virtual symposium would not have been possible without the extraordinary effort by the CUE staff, Lisa Kendrick, Operations Manager, and Jackie Coyne, Administrative Assistant, who designed and developed the event. A special thanks to both of them. Thanks to all the student presenters and their faculty mentors! Dr. Julye Bidmead Director of the Center for Undergraduate Excellence at Chapman University Acknowledgements The Center for Undergraduate Excellence gratefully acknowledge the following individuals and programs for their support: - Dr. Glenn Pfeiffer, Provost - Crean College of Health & Behavioral Sciences - Donna Ford Attallah College of Educational Studies - Schmid College of Science and Technology - Wilkinson College of Arts, Humanities, and Social Sciences A special thanks to the following students, staff, and faculty members for their help with testing and providing feedback on our virtual symposium: Alex Ballard, Alexis Sutterman, Dr. Christopher Kim, Dr. Elaine Schwartz, Emily Cauble, Jacky Dang, Jessica Bocinski, Dr. Kelli Fuery, Dr. Marco Bisoffi, Michaela Montgomery, Dr. Quaylan Allen, Rebecca Green, Valeria Park Schedule of Events Tuesday, May 5 Poster Presentations-Session I 9:00AM-10:30AM Poster Presentations-Session II 10:30AM-12:00PM Oral Presentations-Session I 12:00PM-1:00PM Film and Media Arts Presentations-Session I 1:00PM-2:00PM Oral Presentations-Session II 2:00PM-3:00PM Film and Media Arts Presentations-Session II 3:00PM-4:00PM Visual Art Presentations-Session I 4:00PM-5:00PM Oral Presentations-Session III 5:00PM-6:00PM Wednesday, May 6 Oral Presentations-Session IV 9:00AM-10:00AM Oral Presentations-Session V 10:00AM-11:00AM Oral Presentations-Session VI 11:00AM-12:00PM Poster Presentations-Session III 11:30AM-1:00PM Oral Presentations-Session VII 1:00PM-2:00PM Poster Presentations-Session IV 2:00PM-3:30PM Oral Presentations-Session VIII 4:00PM-5:00PM Oral Presentations-Session IX 5:00PM-6:00PM Table of Contents Message from the Director 1 Acknowledgements 2 Schedule of Events 3 Tuesday, May 5 Poster Presentations Session l: Abstracts Biochemistry and Molecular Biology 6 Biological Sciences 7 Chemistry 10 Computer Science 10 Data Analytics 11 English 11 FFC 14 Film 15 Health & Strategic Communication 15 History 15 Physics 17 Psychology 17 Public Relations and Advertising 20 Poster Presentations Session lI: Abstracts Art 21 Biochemistry and Molecular Biology 21 Biological Sciences 22 Chemistry 22 Communication Studies 23 Computer Science 24 Data Analytics 26 English 26 FFC 29 Film 30 Health Sciences and Kinesiology 30 History 31 Mathematics 32 Music 32 Physical Therapy 33 Physics 34 Psychology 35 Sociology 41 Software Engineering 42 Oral Presentations Session l: Abstracts Film 44 Film and Media Arts Presentations Session I: Abstracts Film 46 Public Relations and Advertising 47 Oral Presentations Session II: Abstracts Film 48 Film and Media Arts Presentations Session I: Abstracts Digital Arts 50 Film 50 Visual Art Presentations Session I: Abstracts Art 52 Digital Arts 53 Oral Presentations Session III: Abstracts History 54 Political Science 54 Wednesday, May 6 Oral Presentations Session IV: Abstracts Film 56 Integrated Educational Studies 56 Interdisciplinary 57 Oral Presentations Session V: Abstracts Physical Therapy 58 Oral Presentations Session VI: Abstracts Mathematics 60 Poster Presentations Session lII: Abstracts Biochemistry and Molecular Biology 61 Biological Sciences 67 Chemistry 69 Communication Sciences and Disorders 71 Communication Studies 72 Computer Science 72 Data Analytics 74 English 74 Environmental Science and Policy 75 FFC 76 Food Science 78 Health Sciences and Kinesiology 79 Mathematics 80 Physical Therapy 80 Physics 81 Political Science 82 Psychology 83 Sociology 87 Oral Presentations Session VIl: Abstracts Religious Studies 89 Sociology 90 Poster Presentations Session lV: Abstracts Biochemistry and Molecular Biology 91 Biological Sciences 92 Chemistry 93 Communication Studies 94 Computer Science 95 Data Analytics 97 English 98 FFC 101 Health Sciences and Kinesiology 102 History 102 Integrated Educational Studies 103 Mathematics 103 Political Science 104 Psychology 104 Religious Studies 107 Oral Presentation Session VIII: Abstracts Film 109 Oral Presentations Session IX: Abstracts Chemistry 111 Index 113 Poster Presentations - Session I Tuesday, May 5 | 9:00AM-10:30AM Biochemistry and Molecular Biology Characterizing the Interaction Between CowN and Nitrogenase Presenter(s): Terrence Lee, Kiersten Chong, Chloe Garcia, Max Strul, Ruchita Kharwa, Emily Wong, Kevin Bretzing Advisor(s): Dr. Cedric Owens Nitrogenase catalyzes the conversion of atmospheric dinitrogen into ammonia. The enzyme produces ammonia under ambient conditions, using the free energy of ATP to drive dinitrogen reduction. The most common form of nitrogenase is molybdenum nitrogenase (Mo-nitrogenase). Mo-nitrogenase is inhibited by the ubiquitous pollutant carbon monoxide (CO). To prevent inhibition of Mo-nitrogenase by CO, nitrogen fixing bacteria produce the protein CowN. In presence of CowN, Mo-nitrogenase avoids inhibition by CO and remains active. However, the mechanism by which CowN protects Mo-nitrogenase is unknown. Enzymatic assays suggest that CowN and Mo-nitrogenase interact with a Kd of approximately 5-10 µM. Here, we present data from crosslinking and pulldown assays that were used to determine how CowN interacts with Mo-nitrogenase. Crosslinking assays using the heterobifunctional crosslinker EDC showed no binding between CowN and Mo-nitrogenase in presence or absence of CO gas. Pulldown assays using Ni- NTA resin with a His-tagged CowN bait also did not show significant binding between CowN to Mo- nitrogenase. These assays indicate that CowN may not have a strong binding enough affinity to Mo- nitrogenase to be detected by crosslinking or pulldown assays. Future work will investigate potential nitrogenase-CowN interaction using fluorescence anisotropy. Exploring The Effect Of The Diarylpentanoid ca27 On The Degradation Of The Androgen Receptor In Prostate Cancer Cells Presenter(s): Emma Beale Advisor(s): Dr. Marco Bisoffi The present study addresses a possible mechanism of action for the diarylpentanoid curcumin analog 27 (ca27), which has been shown to downregulate the androgen receptor (AR) in prostate cancer (PCa) cells. Prostate cells, both normal and cancerous, express the AR, which functions as a hormone-induced cytoplasmic/nuclear receptor and transcription factor promoting cell growth and survival. In PCa, AR expression and activity are overexpressed, and the AR is a major oncoprotein leading to uncontrolled cell growth. ca27 is a synthetic diarylpentanoid analog of the natural product curcumin. Previous research in Dr. Bisoffi’s lab has shown that ca27 downregulates AR expression at low micromolar concentrations in prostate cancer cells. However, the mechanism of action is unknown. The goal of the present work is to determine at what step of the central biological dogma ca27 acts to downregulate AR expression. Specifically, we hypothesize that ca27 interferes with AR protein stability by enhancing its degradation. Using specific inhibitors of transcription, translation, and degradation, applied to human androgen- dependent LNCaP prostate adenocarcinoma cells, preliminary data is presented based on the method of sodium dodecyl sulfate gel electrophoresis (SDS-PAGE) followed by immunological detection by Western blotting and quantitative reverse transcription polymerase chain reaction (qRT-PCR). Our preliminary findings indicate that ca27 is a mediator of protein degradation. A better understanding of the mechanism of action of ca27 with respect to its activity to downregulate AR expression will build the foundation for the development of organic small molecules as therapeutic candidates in the clinical management of PCa. 6 Poster Presentations - Session I Tuesday, May 5 | 9:00AM-10:30AM Characterizing the Ganglioside Content in Human Intestinal Epithelial Cells and Extracellular Vesicles With or Without Supply of Exogenous Gangliosides Presenter(s): Jordan Jernigan Advisor(s): Dr. John Miklavcic Dietary fats play a role in the development, progression, and treatment of chronic diseases. Gangliosides are a type of lipid, or fat, found in all human tissues. Both healthy and diseased cells undergo intercellular communication by secreting vesicles into
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