Abt—Letterer—Siwe Disease 400 Accessory Bones 4 Acetabular
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Original Article Pictorial Atlas of Symptomatic Accessory Ossicles by 18F-Sodium Fluoride (Naf) PET-CT
Am J Nucl Med Mol Imaging 2017;7(6):275-282 www.ajnmmi.us /ISSN:2160-8407/ajnmmi0069278 Original Article Pictorial atlas of symptomatic accessory ossicles by 18F-Sodium Fluoride (NaF) PET-CT Sharjeel Usmani1, Cherry Sit2, Gopinath Gnanasegaran2, Tim Van den Wyngaert3, Fahad Marafi4 1Department of Nuclear Medicine & PET/CT Imaging, Kuwait Cancer Control Center, Khaitan, Kuwait; 2Royal Free Hospital NHS Trust, London, UK; 3Antwerp University Hospital, Belgium; 4Jaber Al-Ahmad Molecular Imaging Center, Kuwait Received August 7, 2017; Accepted December 15, 2017; Epub December 20, 2017; Published December 30, 2017 Abstract: Accessory ossicles are developmental variants which are often asymptomatic. When incidentally picked up on imaging, they are often inconsequential and rarely a cause for concern. However, they may cause pain or discomfort due to trauma, altered stress, and over-activity. Nuclear scintigraphy may play a role in the diagnosis and localizing pain generators. 18F-Sodium Fluoride (NaF) is a PET imaging agent used in bone imaging. Although commonly used in imaging patients with cancer imaging malignancy, 18F-NaF may be useful in the evaluation of benign bone and joint conditions. In this article, we would like to present a spectrum of clinical cases and review the potential diagnostic utility of 18F-NaF in the assessment of symptomatic accessory ossicles in patients referred for staging cancers. Keywords: 18F-NaF PET/CT, accessory ossicles, hybrid imaging Introduction Accessory ossicles are developmental variants which are often asymptomatic. When inciden- Bone and joint pain is a common presentation tally picked up on imaging, they are often incon- in both primary and secondary practice. -
Elbow Arthroscopy for Osteochondral Lesions in Athletes
SPORTS SURGERY ELBOW ARTHROSCOPY FOR OSTEOCHONDRAL LESIONS IN ATHLETES – Written by Luigi Pederzini et al, Italy Several sports specific injuries of the elbow OSTEOCHONDRAL DEFECT have been well-described. For example, Definition and symptoms the prevalence of medial elbow instability Osteochondral defect is a detachment is high in throwing athletes such as of bone and cartilage in a joint that can Osteochondral baseball players. Similarly, javelin throwers, cause pain. The clinical presentation defect is a volleyball players and tennis players are is characterised by an acute or chronic frequently complaining about elbow pain. onset of symptoms. The majority of detachment of This can be the result of intensive training patients with osteochondral defects of or chronic overuse which results in an the elbow complain of pain. In some bone and cartilage acute or chronic injury. Some of these patients the defect is associated with injuries can be osteochondral lesions such a loose body, and the patient presents in a joint that as osteochondral defects, osteochondrosis clinically with pain, giving way, swelling, can cause pain... of the capitulum humeri or osteochondritis catching, clicking, crepitus and elbow dissecans (OCD). stiffness aggravated by joint movements. characterised Standard X-rays are the initial studies of choice, but sometimes are negative. by an acute or Magnetic resonance imaging (MRI) and 3D computed tomography (CT) scan can chronic onset of be extremely useful in establishing an symptoms. accurate diagnosis and to add in pre- operative planning. 210 OSTEOCHONDROSIS OF CAPITULUM HUMERI (PANNER’S DISEASE) Definition and symptoms Panner’s disease, an ostechondrosis of the capitellum, is a rare disorder that usually affects the dominant elbow in individuals younger than 10 years old. -
SAS Journal of Surgery (SASJS) Panner's Disease: About a Case
SAS Journal of Surgery (SASJS) ISSN 2454-5104 Abbreviated Key Title: SAS J. Surg. ©Scholars Academic and Scientific Publishers (SAS Publishers) A Unit of Scholars Academic and Scientific Society, India Panner's Disease: About A Case Mohamed Ben-Aissi1, Redouane Hani1, Mohammed Kadiri1, Mouad Beqqali-Hassani1, Paolo Palmari2, Moncef Boufettal1, Mohamed Kharmaz1, Moulay Omar Lamrani1, Ahmed El Bardouni1, Mustapha Mahfoud1, Mohamed Saleh Berrada1 1Orthopedic surgery and traumatology department, Ibn Sina Hospital, Rabat, Morocco 2Orthopedic surgery and traumatology departemnt, Robert Ballanger Hospital, Paris, France Abstract: Panner's disease, or osteochondrosis of the lateral condylar nucleus, is an Case Report avascular necrosis leading to subchondral bone loss, it was first described in 1927. We report a case of Panner's disease, which has been evolving since 1 month, in a child of 8 *Corresponding author years sportsman practicing karate. The evolution was favorable with restitution ad Mohamed Ben-Aissi integrum in 8 months after a short anti-inflammatory treatment and a sports rest of 3 months, without any immobilization of the neither elbow nor surgical intervention. Article History Keywords: Osteochondrosis, Panner’s disease, Treatment. Received: 03.10.2018 Accepted: 06.10.2018 INTRODUCTION Published: 30.10.2018 Panner's disease, or osteochondrosis of the lateral condylar nucleus, is an avascular necrosis leading to a loss of subchondral bone fissuring the radio-humeral DOI: articular surfaces, occurring in the hyperspottive child, in connection with an overuse of 10.21276/sasjs.2018.4.10.7 the elbow [1, 2]. It was first described in 1927 by Dane Panner, a Danish orthopedic surgeon [2, 3]. -
Alport Syndrome of the European Dialysis Population Suffers from AS [26], and Simi- Lar Figures Have Been Found in Other Series
DOCTOR OF MEDICAL SCIENCE Patients with AS constitute 2.3% (11/476) of the renal transplant population at the Mayo Clinic [24], and 1.3% of 1,000 consecutive kidney transplant patients from Sweden [25]. Approximately 0.56% Alport syndrome of the European dialysis population suffers from AS [26], and simi- lar figures have been found in other series. AS accounts for 18% of Molecular genetic aspects the patients undergoing dialysis or having received a kidney graft in 2003 in French Polynesia [27]. A common founder mutation was in Jens Michael Hertz this area. In Denmark, the percentage of patients with AS among all patients starting treatment for ESRD ranges from 0 to 1.21% (mean: 0.42%) in a twelve year period from 1990 to 2001 (Danish National This review has been accepted as a thesis together with nine previously pub- Registry. Report on Dialysis and Transplantation in Denmark 2001). lished papers by the University of Aarhus, February 5, 2009, and defended on This is probably an underestimate due to the difficulties of establish- May 15, 2009. ing the diagnosis. Department of Clinical Genetics, Aarhus University Hospital, and Faculty of Health Sciences, Aarhus University, Denmark. 1.3 CLINICAL FEATURES OF X-LINKED AS Correspondence: Klinisk Genetisk Afdeling, Århus Sygehus, Århus Univer- 1.3.1 Renal features sitetshospital, Nørrebrogade 44, 8000 Århus C, Denmark. AS in its classic form is a hereditary nephropathy associated with E-mail: [email protected] sensorineural hearing loss and ocular manifestations. The charac- Official opponents: Lisbeth Tranebjærg, Allan Meldgaard Lund, and Torben teristic renal features in AS are persistent microscopic hematuria ap- F. -
The Ehlers–Danlos Syndromes
PRIMER The Ehlers–Danlos syndromes Fransiska Malfait1 ✉ , Marco Castori2, Clair A. Francomano3, Cecilia Giunta4, Tomoki Kosho5 and Peter H. Byers6 Abstract | The Ehlers–Danlos syndromes (EDS) are a heterogeneous group of hereditary disorders of connective tissue, with common features including joint hypermobility, soft and hyperextensible skin, abnormal wound healing and easy bruising. Fourteen different types of EDS are recognized, of which the molecular cause is known for 13 types. These types are caused by variants in 20 different genes, the majority of which encode the fibrillar collagen types I, III and V, modifying or processing enzymes for those proteins, and enzymes that can modify glycosaminoglycan chains of proteoglycans. For the hypermobile type of EDS, the molecular underpinnings remain unknown. As connective tissue is ubiquitously distributed throughout the body, manifestations of the different types of EDS are present, to varying degrees, in virtually every organ system. This can make these disorders particularly challenging to diagnose and manage. Management consists of a care team responsible for surveillance of major and organ-specific complications (for example, arterial aneurysm and dissection), integrated physical medicine and rehabilitation. No specific medical or genetic therapies are available for any type of EDS. The Ehlers–Danlos syndromes (EDS) comprise a genet six EDS types, denominated by a descriptive name6. The ically heterogeneous group of heritable conditions that most recent classification, the revised EDS classification in share several clinical features, such as soft and hyper 2017 (Table 1) identified 13 distinct clinical EDS types that extensible skin, abnormal wound healing, easy bruising are caused by alterations in 19 genes7. -
Pediatric MSK Protocols
UT Southwestern Department of Radiology Ankle and Foot Protocols - Last Update 5-18-2015 Protocol Indications Notes Axial Coronal Sagittal Ankle / Midfoot - Routine Ankle Pain Axial = In Relation to Leg "Footprint" (Long Axis to Foot) T1 FSE PD SPAIR T1 FSE Injury, Internal Derangement Coronal = In Relation to Leg (Short Axis Foot) PD SPAIR STIR Talar OCD, Coalition Protocol Indications Notes Axial Coronal Sagittal Ankle / Midfoot - Arthritis Arthritis Axial = In Relation to Leg "Footprint" (Long Axis to Foot) PD SPAIR PD SPAIR T1 FSE Coronal = In Relation to Leg (Short Axis Foot) STIR T1 SPIR POST T1 SPIR POST Protocol Indications Notes Axial Coronal Sagittal Foot - Routine Pain, AVN Axial = In Relation to Leg "Footprint" (Long Axis to Foot) T1 FSE PD FSE T1 FSE Coronal = In Relation to Leg (Short Axis Foot) PD SPAIR PD SPAIR STIR Protocol Indications Notes Axial Coronal Sagittal Foot - Arthritis Arthritis Axial = In Relation to Leg "Footprint" (Long Axis to Foot) T1 FSE PD SPAIR STIR Coronal = In Relation to Leg (Short Axis Foot) PD SPAIR T1 SPIR POST 3D WATS T1 SPIR POST Protocol Indications Notes Axial Coronal Sagittal Great Toe / MTP Joints Turf Toe Smallest Coil Possible (Microcoil if Available) PD FSE T1 FSE PD FSE Sesamoiditis FoV = Mid Metatarsal Through Distal Phalanges PD SPAIR PD SPAIR PD SPAIR Slice thickness = 2-3 mm, 10% gap Axial = In relation to the great toe (short axis foot) Coronal = In relation to the great toe (long axis foot / footprint) Appropriate Coronal Plane for Both Ankle and Foot Imaging UT Southwestern Department -
The Skeletal System
Essentials of Human Anatomy & Physiology Seventh Edition Foundation • Physical Foundation of the Body The Skeletal System – 206 Bones • Osteology – science of the anatomy, structure, and function of bones – “Os” means Bone • With the exception of teeth, bone IS the hardest substance in the body Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings The Skeletal System • Parts of the skeletal system • Bones (skeleton) • Joints • Cartilages • Ligaments (bone to bone)(tendon=bone to muscle) • Divided into two divisions • Axial skeleton • Copyright © 2003Appendicular Pearson Education, Inc. publishing as Benjaminskeleton Cummings – limbs and girdle 1 Functions of Bones Bones of the Human Body • The skeleton has 206 bones • Support of the body • Two basic types of bone tissue • Protection of soft organs • Compact bone • Movement due to attached skeletal • Homogeneous muscles • Spongy bone • Storage of minerals and fats (K, Mg, • Small needle-like pieces of bone Na) Figure 5.2b • Many open spaces • Blood cell formation (White and Red) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Classification of Bones Classification of Bones • Long bones • Short bones • Typically longer than wide • Generally cube-shape • Have a shaft with heads at both ends • Contain mostly spongy bone • Contain mostly compact bone •Examples: Carpals, tarsals • Examples: Femur, humerus Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings 2 Classification of Bones on the Classification of Bones Basis of Shape • Flat bones • Thin and flattened • Usually curved • Thin layers of compact bone around a layer of spongy bone •Examples: Skull, ribs, sternum Figure 5.1 Copyright © 2003 Pearson Education, Inc. -
Everything Within Reach! Myoelectric-Controlled Arm Prostheses
Everything within Reach! Myoelectric-controlled Arm Prostheses Information for user Table of Contents Myoelectric-controlled Arm Prostheses ������������������������������������������ 4 Cable-controlled Arm Prostheses ����������������������������������������������������� 6 Passive Arm Prostheses ����������������������������������������������������������������������� 8 Technology for People ���������������������������������������������������������������������������� 9 Prosthetic Fitting ����������������������������������������������������������������������������������� 10 System Electric Hands ����������������������������������������������������������������������� 12 SensorHand Speed ����������������������������������������������������������������������������� 14 System Electric Greifers �������������������������������������������������������������������� 16 Individual Combination and Adaptation ����������������������������������������� 18 Upper Arm Prostheses – DynamicArm ������������������������������������������� 20 Making Exploration Fun ��������������������������������������������������������������������� 24 Children’s Hand 2000 ������������������������������������������������������������������������� 26 Post-operative Therapy ����������������������������������������������������������������������� 28 Residual Limb Pain and Phantom Pain ������������������������������������������ 30 The Socket Decides ���������������������������������������������������������������������������� 32 Pay Attention to Yourself! ������������������������������������������������������������������� -
Genetic Disorder
Genetic disorder Single gene disorder Prevalence of some single gene disorders[citation needed] A single gene disorder is the result of a single mutated gene. Disorder Prevalence (approximate) There are estimated to be over 4000 human diseases caused Autosomal dominant by single gene defects. Single gene disorders can be passed Familial hypercholesterolemia 1 in 500 on to subsequent generations in several ways. Genomic Polycystic kidney disease 1 in 1250 imprinting and uniparental disomy, however, may affect Hereditary spherocytosis 1 in 5,000 inheritance patterns. The divisions between recessive [2] Marfan syndrome 1 in 4,000 and dominant types are not "hard and fast" although the [3] Huntington disease 1 in 15,000 divisions between autosomal and X-linked types are (since Autosomal recessive the latter types are distinguished purely based on 1 in 625 the chromosomal location of Sickle cell anemia the gene). For example, (African Americans) achondroplasia is typically 1 in 2,000 considered a dominant Cystic fibrosis disorder, but children with two (Caucasians) genes for achondroplasia have a severe skeletal disorder that 1 in 3,000 Tay-Sachs disease achondroplasics could be (American Jews) viewed as carriers of. Sickle- cell anemia is also considered a Phenylketonuria 1 in 12,000 recessive condition, but heterozygous carriers have Mucopolysaccharidoses 1 in 25,000 increased immunity to malaria in early childhood, which could Glycogen storage diseases 1 in 50,000 be described as a related [citation needed] dominant condition. Galactosemia -
Tietze Syndrome
J Surg Med. 2020;4(9):835-837. Review DOI: 10.28982/josam.729803 Derleme Tietze syndrome Tietze sendromu İsmail Ertuğrul Gedik 1, Timuçin Alar 1 1 Çanakkale Onsekiz Mart University Faculty Abstract of Medicine Department of Thoracic Surgery, Tietze syndrome, first described in 1921 by Prof. Alexander TIETZE, is characterized with tender nonsuppurative swelling, pain, and Çanakkale, Turkey tissue edema in the second or third costosternal cartilage. Differential diagnosis of Tietze syndrome includes diverse diseases, and its diagnosis relies on clinical examination, not the use of additional diagnostic techniques. The treatment of Tietze syndrome includes the ORCID ID of the author(s) use of anti-inflammatory medication and implementation of lifestyle modifications during the attacks. Surgical treatment is reserved for İEG: 0000-0002-1667-4793 refractory cases and often is not necessary. Tietze syndrome can easily be diagnosed and treated in primary care medicine practice due TA: 0000-0002-4719-002X to its benign nature. Keywords: Tietze syndrome, Differential diagnosis, Treatment, Lifestyle modifications Öz Tietze sendromu ilk olarak 1921 yılında Prof. Alexander TIETZE tarafından tanımlanmıştır. Tietze sendromu ikinci veya üçüncü kostosternal kartilajda süpüratif olmayan, şişlik, hassasiyet, ağrı ve doku ödemi olarak tanımlanır. Tietze sendromunun ayırıcı tanısı birçok farklı hastalığı kapsamaktadır. Tietze sendromu tanısı esas olarak kliniktir olup genellikle ek tanı yöntemlerinin kullanılmasını zorunlu kılmaz. Tietze sendromunun tedavisi -
A CLINICAL STUDY of 25 CASES of CONGENITAL KEY WORDS: Ectromelia, Hemimelia, Dysmelia, Axial, Inter- LIMB DEFICIENCIES Calary
PARIPEX - INDIAN JOURNAL OF RESEARCH Volume-7 | Issue-1 | January-2018 | PRINT ISSN No 2250-1991 ORIGINAL RESEARCH PAPER Medical Science A CLINICAL STUDY OF 25 CASES OF CONGENITAL KEY WORDS: Ectromelia, Hemimelia, Dysmelia, Axial, Inter- LIMB DEFICIENCIES calary M.B.B.S., D.N.B (PMR), M.N.A.M.S Medical officer, D.P.M.R., K.G Medical Dr Abhiman Singh University Lucknow (UP) An Investigation of 25 patients from congenital limb deficient patients who went to D. P. M. R. , K.G Medical University Lucknow starting with 2010 with 2017. This study represents the congenital limb deficient insufficient number of the India. Commonest deficiencies were Adactylia Also mid Ectromelia (below knee/ below elbow deficiency).Below knee might have been basic in male same time The following elbow for female Youngsters. No conclusive reason for the deformity might be isolated, however, A large number guardians accepted that possible exposure to the eclipse throughout pregnancy might have been those reason for ABSTRACT those deficiency. INTRODUCTION Previous Treatment Only 15 patients had taken some D. P. M. R., K.G Medical University Lucknow (UP) may be a greatest treatment, 5 underwent some surgical treatment and only 4 Also its identity or sort of Rehabilitation Centre in India. Thusly the patients used prosthesis. This indicates the ignorance or lack of limb deficient children attending this department can easily be facilities to deal with the limb deficient children. accepted as a representative sample of the total congenital limb deficiency population in the India. DEFICIENCIES The deficiencies are classified into three categories:- MATERIAL AND METHODS This study incorporates 25 patients congenital limb deficiency for 1) Axial Dysmelia where medial or lateral portion is missing lack who originated for medicine at D. -
(12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub
US 2010O2.10567A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0210567 A1 Bevec (43) Pub. Date: Aug. 19, 2010 (54) USE OF ATUFTSINASATHERAPEUTIC Publication Classification AGENT (51) Int. Cl. A638/07 (2006.01) (76) Inventor: Dorian Bevec, Germering (DE) C07K 5/103 (2006.01) A6IP35/00 (2006.01) Correspondence Address: A6IPL/I6 (2006.01) WINSTEAD PC A6IP3L/20 (2006.01) i. 2O1 US (52) U.S. Cl. ........................................... 514/18: 530/330 9 (US) (57) ABSTRACT (21) Appl. No.: 12/677,311 The present invention is directed to the use of the peptide compound Thr-Lys-Pro-Arg-OH as a therapeutic agent for (22) PCT Filed: Sep. 9, 2008 the prophylaxis and/or treatment of cancer, autoimmune dis eases, fibrotic diseases, inflammatory diseases, neurodegen (86). PCT No.: PCT/EP2008/007470 erative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the S371 (c)(1), present invention relates to pharmaceutical compositions (2), (4) Date: Mar. 10, 2010 preferably inform of a lyophilisate or liquid buffersolution or artificial mother milk formulation or mother milk substitute (30) Foreign Application Priority Data containing the peptide Thr-Lys-Pro-Arg-OH optionally together with at least one pharmaceutically acceptable car Sep. 11, 2007 (EP) .................................. O7017754.8 rier, cryoprotectant, lyoprotectant, excipient and/or diluent. US 2010/0210567 A1 Aug. 19, 2010 USE OF ATUFTSNASATHERAPEUTIC ment of Hepatitis BVirus infection, diseases caused by Hepa AGENT titis B Virus infection, acute hepatitis, chronic hepatitis, full minant liver failure, liver cirrhosis, cancer associated with Hepatitis B Virus infection. 0001. The present invention is directed to the use of the Cancer, Tumors, Proliferative Diseases, Malignancies and peptide compound Thr-Lys-Pro-Arg-OH (Tuftsin) as a thera their Metastases peutic agent for the prophylaxis and/or treatment of cancer, 0008.