(12) Patent Application Publication (10) Pub. No.: US 2010/0068299 A1 Van Der Krieken Et Al
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US 2010.0068299A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2010/0068299 A1 Van der Krieken et al. (43) Pub. Date: Mar. 18, 2010 (54) LIGNOSULFONATE COMPOSITIONS FOR of application No. 10/543,702, filed on Apr. 17, 2006, CONTROL OF PLANT PATHOGENS filed as application No. PCT/EP04/00742 on Jan. 27, 2004. (76) Inventors: Wilhelmus Maria van der Krieken, Wageningen (NL); (30) Foreign Application Priority Data Cornelis Johannes Kok, Elst (NL); Lucas Henricus Stevens, Utrecht Jan. 27, 2003 (EP). ... PCTAEPO3 FOO840 (NL); Evert Davelarr, Veenendaal Publication Classification (NL) (51) Int. Cl. Correspondence Address: AOIN 59/20 (2006.01) AGRAQUEST, INC. AOIN 6L/00 (2006.01) 1540. DREWAVENUE AOIP I/00 (2006.01) DAVIS, CA 95618 (US) (52) U.S. Cl. ........................................... 424/638: 514/22 (21) Appl. No.: 12/496,492 (57) ABSTRACT The present invention relates to a composition comprising a (22) Filed: Jul. 1, 2009 soluble combination comprising lignoSulfonate, a metal salt, and a phosphorus compound selected from the group consist Related U.S. Application Data ing of phosphorus acid and spontaneously soluble salts (63) Continuation-in-part of application No. PCT/NL2008/ thereof, and mixtures thereof. The present invention also 050796, filed on Dec. 12, 2008, Continuation-in-part relates to the use of Such compositions as pesticides. Patent Application Publication Mar. 18, 2010 Sheet 1 of 5 US 2010/0068299 A1 Figure 1 Patent Application Publication Mar. 18, 2010 Sheet 2 of 5 US 2010/0068299 A1 O 25 O 5 blA Figure 2 Patent Application Publication Mar. 18, 2010 Sheet 3 of 5 US 2010/0068299 A1 C 4 (6 days C 4 Q 12 days KOC de C6 days KOC de Q 12 days Figure 3 Patent Application Publication Mar. 18, 2010 Sheet 4 of 5 US 2010/0068299 A1 Figure 4 Patent Application Publication Mar. 18, 2010 Sheet 5 of 5 US 2010/0068299 A1 Kphosphite salt Figure 5 US 2010/0068299 A1 Mar. 18, 2010 LGNOSULFONATE COMPOSITIONS FOR precipitates from phosphorus compounds and metal salts that CONTROL OF PLANT PATHOGENS are dissolved in aqueous solvents before and during their combined application. The compositions of the present inven CROSS-REFERENCE TO RELATED tion are useful in the control of plant pathogens, i.e. as a APPLICATIONS fungicide or as a bactericide, and as a plant fertilizer. 0001. The present application claims priority to and is a 0009. The present invention provides compositions of Continuation-In-Part of International Patent Application No. plant protecting agents and/or plant fertilizing agents and PCT/NL2008/050796 filed Dec. 12, 2008, which claims pri methods which substantially prevent the formation of copper ority to European Patent Application No. 2007 123860.4 filed or metal phosphite precipitates from phosphorus acid, and/or on Dec. 20, 2007, and this application also claims priority to a salt and/or a hydrate and/or an ester thereof and metal salts U.S. patent application Ser. No. 10/543,702, which in turn that are dissolved in aqueous solvents before and during their claims priority as a National Stage Entry of International combined application. Hence, the methods ensure that after Patent Application No. PCT/EP2004/000742, filed Jan. 27, application, the active ingredients remain relatively immobile 2004, which in turn claims priority to International Patent Application No. PCT/EP2003/000840, filed Jan. 27, 2003. over the long term. Each of the foregoing applications is hereby incorporated by 0010. The present invention provides a composition com reference in its entirety. prising at least one soluble combination comprising at least one lignoSulfonate, at least one metal salt, and at least one TECHNICAL FIELD phosphorus compound, wherein the composition excludes a 0002. This invention relates to the technical field of for solubilizing amount of a chelator. In one embodiment, the mulation technology of plant protection agents and and/or composition is in liquid form. In one embodiment, the com plant fertilizing agents and to methods of preparing and using position is a solution. In other embodiments, the composition Such formulations. is a water soluble powder or a water Soluble granule. In one embodiment, the soluble composition further comprises at BACKGROUND least one compound as to form a composition with a pH 0003) Agricultural production worldwide is under perma within a range from about 4.8 to about 5.8. Alternatively, the nent threat from numerous phytopathogenic fungi and bacte composition further comprises a buffer salt with a pH within ria. For the protection of yield and quality of products and to a range from about 4.8 to about 5.8. avoid economic losses, the application of chemical agents 0011. The present invention also provides methods of pre that control plant diseases are an absolute requirement. venting formation of a metal phosphite precipitate in an aque Although the need for pesticides is generally acknowledged, ous solvent. there is an ongoing public concern about the possible negative 0012. The present invention also relates to methods for impact of pesticides on the environment and on human health. preparing an aqueous composition comprising at least one As a consequence, the demands with respect to Sustainability metal compound, at least one lignoSulfonate and at least one of chemical pest control are continually increasing, as are the phosphorus compound. costs to bring new pesticides to the market. 0013 The present invention further provides methods for 0004 EP A 249.566 discloses bactericide compositions controlling plant pathogens. In one embodiment, the present comprising a metal salt of a phosphorus acid monoester, said invention provides a method for controlling plant pathogens bactericide compositions being used for treating plants Suf by using said composition as a fungicide. In one embodiment, fering from bactericidal diseases. Examples C, E and H dis the present invention provides a method for controlling plant close such a bactericide composition in powder form which pathogens by using said composition as a bactericide. further contains calcium or sodium lignoSulfonate and 0014. The present invention further provides methods of optionally a metal salt, e.g. calcium carbonate. using said composition as a fertilizer. 0005 U.S. Pat. No. 4,139,616 discloses compositions for controlling fungus diseases which containas active material a metal salt of a phosphorus acid monoester. Examples 1 and 2 BRIEF DESCRIPTION OF THE DRAWINGS disclose Such compositions as wettable powders which fur ther contain 5% calcium lignoSulfate. (0.015 FIG. 1 represents DuPontTM KOCIDE(R) 2000 fun 0006 U.S. Pat. No. 6,689,392 discloses compositions for gicide/bactericide and Composition 4. As it shows, controlling plant pathogens comprising an effective amount KOCIDE(R) 2000 is a suspension of wettable powder, while of a metalion, a chelating agent, and phosphorus acid, and/or Composition 4 is a solution of water soluble powder. salt or hydrate thereof, which further contain from about 1% 0016 FIG. 2 represents results of controlling late blight to 10% of an acidifying agent such as lignoSulfonate. (Phytophthora infestans) on tomato in the greenhouse by 0007. The present invention meets a long felt need for Composition 4 (C. 4) and DuPontTM KOCIDE(R) 2000 fungi improved compositions for preventing and/or treating plant cide/bactericide. pathogens, wherein such compositions contain metal as an 0017 FIG.3 represents results of controlling downy mil active compound. dew (Pseudoperonospora cubensis) on cucumber in the greenhouse by Composition 4 (C. 4) and DuPontTM SUMMARY KOCIDE(R) 2000 fungicide/bactericide. 0008. The present invention provides formulation tech 0018 FIG. 4 represents cucumber plants sprayed with nologies for Soluble compositions of plant protecting agents Composition 4 and DuPontTM KOCIDE(R) 2000 fungicide/ and/or plant fertilizing agents and to methods which Substan bactericide. Picture was taken six days after downy mildew tially or completely prevent the formation of metal phosphite infection. US 2010/0068299 A1 Mar. 18, 2010 0019 FIG. 5 represents results of controlling tomato 0030. As used herein, the term “suspension” refers to a speck (Pseudomonas syringae) on cucumber in the green heterogeneous fluid containing solid particles that are suffi house by Composition 4 (C. 4) and DuPontTM KOCIDE(R) ciently large for sedimentation. 2000 fungicide/bactericide. 0031. As used herein, the term “colloid” refers to a type of chemical mixture where one substance is dispersed evenly DETAILED DESCRIPTION throughout another. The particles of the dispersed substance are only suspended in the mixture, unlike a solution, where 0020 All publications, patents and patent applications, they are completely dissolved within. including any claims, drawings and appendices, herein are 0032. As used herein, the term “chelator” refers to a bi- or incorporated by reference to the same extent as if each indi multidentate ligand used in agricultural practice that is often vidual publication or patent application was specifically and an organic compound, also called chelant, chelating agent or individually indicated to be incorporated by reference. sequestering agent. Chelators are chemicals that form 0021. The following description includes information that soluble, complex molecules with certain metal ions, inacti may be useful in understanding the present invention. It is not Vating the ions so that they cannot normally react with other an admission that any of the information provided herein is elements or ions to produce precipitates or scale. Chelators prior art or relevant to the presently claimed inventions, or generally form one or more coordination bonds with a central that any publication specifically or implicitly referenced is metal ion, resulting in heterocyclic rings with the central prior art. metalion as part of the ring. Examples of chelators are phos phines, amines, diphosphines, diamines, EDTA, EDDHA, Definitions HEDTA, DTPA, citrate, saccharate, gluconate, glucohepto 0022. As used herein, the term “soluble” refers to the nate and glycine.