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Jebmh.Com Case Report Jebmh.com Case Report SOLITARY PLASMACYTOMA OF MAXILLA IN A HBSAG POSITIVE PATIENT: A CASE REPORT Rajkumar P. N1, Manjunath N. M2, Dinesh M. G3, Preema M. Pinto4, Veerendra Kumar5 1Assistant Professor, Department of General Surgery, Bangalore Medical College & Research Institute. 2Assistant Professor, Department of Faciomaxillary Surgery & Dentistry, MVJMC & RC. 3Assistant Professor, Department of General Surgery, KIMS, Bangalore. 4Consultant Orthodontist, Department of Orthodontics, MVJMC & RC. 5Assistant Professor, Department of OMFS, Vydehi Institute of Dental Sciences. ABSTRACT: Plasma cell neoplasm’s constitute a group of disorders characterized by monoclonal proliferation of plasma cells and presence of monoclonal immunoglobulin in the serum. We report a case of solitary bone plasmacytoma of maxilla, a variant of PCNs. Because solitary bone plasmacytoma are quite rare in the oral cavity, they are often not commonly included in the differential diagnosis of lesions occurring in the maxillary palatal region. The definitive diagnosis requires computed tomography scan, histopathological examination and immunoelectrophoresis. KEYWORDS: Plasmacytoma, solitary, plasma cells, HBsAg, extramedullary. HOW TO CITE THIS ARTICLE: Rajkumar P. N, Manjunath N. M, Dinesh M. G, Preema M. Pinto, Veerendra Kumar. “Solitary Plasmacytoma of Maxilla in a HBSAG Positive Patient: A Case Report”. Journal of Evidence based Medicine and Healthcare; Volume 2, Issue 45, November 05, 2015; Page: 8204-8207, DOI: 10.18410/jebmh/2015/1104 INTRODUCTION: Plasmacytoma is defined as any gingivobuccal sulcus was normal. There was no proptosis discrete, solitary mass of neoplastic plasma cells either in or abnormality of vision. No cervical lymph node palpable bone marrow or in various soft tissue sites.1-3 PCNs clinically. [Figure 1] occurring in head and neck region are classified by Batsakis On anterior rhinoscopy, no growth was seen in the into three types: Extra medullary plasmacytoma, solitary nasal cavity. Posterior rhinoscopy was normal. Nasal plasmacytoma of bone and manifestation of multiple endoscopy with a 0 degrees rigid endoscope showed no myeloma.4 They account for approximately 3% of plasma abnormality. cell tumors, and for less than 1% of head and neck The paranasal sinuses radiograph showing opacity of tumors.5,6 The disease is more common in males, with the right maxillary sinus. Paranasal sinus CT scan showed male: female ratio of 2:1frequently presents during the heterogenous mass involving right half of hard palate with fifth and sixth decades of life. Solitary bone plasmacytoma has a male: female ratio of 2:1, with a median age of 55 destruction of postero lateral wall of right maxilla. [Figure years and primarily affects the axial skeleton especially the 2]. vertebrae7 (Dimopoulos et al, 2000). Osseous lesions Incisional biopsy was done and Histopathology of mass constitute approximately 70% of all plasmacytomas. They showed features of plasmocytoma with amyloid deposition, involve primarily marrow-containing bones, with a cells with nucleus seen place eccentrically and with predilection for the vertebrae, femur, and pelvis8 (Bolek et prominent nucleus [Figure3]. Immuno staining showed al., 1996). International Myeloma Working Group has set neoplastic cells strongly positive for CD 138 and cells up diagnostic criteria for solitary plasmacytoma of bone, positive for leucocyte common antigen and creatinine extramedullary plasmacytoma and multiple solitary kinase. [Figure 4] plasmacytomas (table 1). We report a case of solitary Serum electrophoresis showed sharp monoclonal plasmacytoma occurring in maxillary palatal region. paraprotein measuring 1.5g/dl in gamma globulin region. Pattern suggestive of monoclonal gammopathy with rise in CASE REPORT: A 55 year old previously healthy lady with Ig-G and beta 2 micro globulin seen. [Figure 5] no comorbidities presented to us with history of swelling Blood investigation reports were normal except for and pain in the right hard palate region of maxilla since 3 positive hepatitis B serology. months. History of loosening and fall of tooth were Rest of axial skeleton imaging and bone marrow present. On clinical examination the swelling on right hard aspiration were normal. palate was firm, tender, fixed 4x6 cm extending from 1st pre molar to soft palate, not crossing mid line, no active DISCUSSION: Plasma cell neoplasms (PCNs) are rare bleed on touch, with free overlying mucosa. Right upper lymphoid disorder arising due to monoclonal proliferation of β cells that undergoes malignant transformation into Submission 20-10-2015, Peer Review 21-10-2015, Acceptance 28-10-2015, Published 05-11-2015. plasmacytoid cells. Manifests as generalised or localised Corresponding Author: form. The generalised form involving multiple bones is Manjunath M. N, called multiple myeloma (MM), with incidence of 9,10 Department of Faciomaxillary Surgery & Dentistry, approximately 95%. The localised form may involve a MVJ Medical College. single bone – solitary bone plasmacytoma (SBP) or only E-mail: [email protected] soft tissues - extramedullary plasmacytoma (EMP). DOI: 10.18410/jebmh/2015/1104 J of Evidence Based Med & Hlthcare, pISSN- 2349-2562, eISSN- 2349-2570/ Vol. 2/Issue 45/Nov. 05, 2015 Page 8204 Jebmh.com Case Report Plasmacytomas account for approximately 3% of multinucleated giant cells are also seen. The nuclei are oval plasma cell tumors and less than 1% of head and neck to round, eccentrically located with dispersed (clock faced) tumors. MM is the most important symptomatic monoclonal nuclear chromatin and halo area. The presence of gammopathy and represents approximately 1% of all associated inflammation and plasma cell infiltration makes 11 cancers, and 10% of all hematological neoplasm’s. It is diagnosis difficult. Differential diagnosis of plasmacytomas characterized by numerous abnormal plasma cells includes benign reactive plasmacytosis, undifferentiated permeating the bone marrow and overproduction of carcinoma, NHL, malignant melanoma and esthesioneuro- monoclonal light-chain or heavy-chain immunoglobulin’s blastoma. Hence immunohistochemistry plays vital role in that are identifiable in serum or urine.12 The exact etiology making diagnosis. is not known, exposure to certain chemicals, irradiation, PCN are highly radio sensitive. Radiotherapy is viruses and genetic factors have been suggested.13 The 21 diagnostic criteria for SBP and EMP are mentioned in Table. treatment of choice for SPB or EMP. RT given at dose of 1.14 The diagnosed by histologic confirmation of a 4000 - 6000 c GY in daily fractions over 4-6 weeks is malignant proliferation of plasma cells, hematologic and treatment of choice and provides excellent loco regional biochemical findings, urine analysis and skeletal control.26 Surgery is rarely indicated in cases of RT radiographic survey.15 Several case reports with SBP and refractory cases and localised disease confined to parotid, HIV have been reported but there is no literature of SBP thyroid gland or cervical lymph nodes. Chemotherapy has occurring in a hepatitis B positive patient. We could not no role to play. find any cause or association of SBP in hepatitis patient. *A small M-component may sometimes be present in CONCLUSION: PCN s presenting in head and neck region blood or urine. is rare and may be part of a systemic disease like multiple SPB is uncommon tumor of plasma cells, which myeloma. A high index of suspicion and thorough initial manifests itself as a single osteolytic lesion without histopathological. plasmocytosis of bone marrow not affecting other parts of Work-up may help in establishing a definitive diagnosis skeleton and constitutes approximately 3% of all plasma and providing optimum treatment. cell neoplasms. SPB is more common in males, with male: MM must be differentiated from EMP and SPB as female ratio is 2:1 with a median age of 55 years. The treatment and prognosis differ. Early diagnosis and most common sites of SPB are vertebrae and long bones. effective treatment is essential in the management of SBP rarely involves head and neck region. 30-60% of SBP solitary bone plasmacytoma because of its rarity and late progress to MM and 10 year survival rate is 16%.16 stage of presentation. The diagnosis is confirmed by single Its presence in maxilla is extremely rare. The lytic bony lesion in patient with normal skeletal survey and presenting symptom may be very vague, non-specific normal bone marrow biopsy. RT is treatment of choice. depending on site or pain in the hard palate and teeth, Long term follow up is necessary to identify recurrence or paraesthesia, anesthesia, mobility and migration of the multiple myeloma development. teeth, hemorrhage, swelling in hard and soft tissues and pathological fractures.17-22 In our case the main complaint REFERENCES: was pain and swelling in hard palate. 1. Alexiou C, RJ, Dietzfelbinger H, Kremer M, Spiess JC, 20-30% of EMP progress to MM. 10 year survival is Schratzenstaller B, Arnold W, Extramedullary 70%.23 While treating these patients one must be careful plasmacytoma: Tumor occurrence and therapeutic to differentiate MM from SPB or EMP because treatment concepts. Cancer 1999: 85: 2305-2314. and prognosis differ. 5-10% of SPB or EMP may be 2. Wiltshaw E. The natural history of extramedullary misdiagnosed as MM in early stage. The prognosis of SPB plasmacytoma and its relation of bone and is poorer than EMP and approximately 50% of SPB will myelomatosis. Medicine (Baltimore) 1976; 55: 217- transform
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