(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/071279 A2 8 May 20 14 (08.05.2014) W P O P C T

(51) International Patent Classification: (74) Agent: McCLELLAN, Kelly Brett; Genomic Health, C12Q 1/68 (2006.01) Inc., 301 Penobscot Drive, Redwood City, California 94063 (US). (21) International Application Number: PCT/US2013/068236 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 4 November 2013 (04.1 1.2013) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (26) Publication Language: English KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 61/722,634 5 November 2012 (05. 11.2012) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 61/766,561 19 February 2013 (19.02.2013) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (71) Applicant: GENOMIC HEALTH, INC. [US/US]; 301 ZW. Penobscot Drive, Redwood City, California 94063 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: MA, Yan; 301 Penobscot Drive, Redwood kind of regional protection available): ARIPO (BW, GH, City, California 94063 (US). QU, Kunbin; 301 Penobscot GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, Drive, Redwood City, California 94063 (US). LIU, Mei- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Lan; 301 Penobscot Drive, Redwood City, California TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 94063 (US). AMBANNAVAR, Ranjana; 301 Penobscot EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, ΓΓ, LT, LU, LV, Drive, Redwood City, California 94063 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, STEPHANS, James; 301 Penobscot Drive, Redwood TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, City, California 94063 (US). PAN, John; 2547 W. Avenue KM, ML, MR, NE, SN, TD, TG). 30, Los Angeles, California 90065 (US).

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(54) Title: GENE FUSIONS AND ALTERNATIVELY SPLICED JUNCTIONS ASSOCIATED WITH BREAST CANCER (57) Abstract: The present invention relates to gene fusions Figure 1 and alternative spliced junctions associated with breast can cer. The present invention also relates to novel methods of A . identifying gene fusions and alternative spliced junctions in Sample based Cohort based RNA sequencing data. The present invention further relates Step 6 to predicting prognosis of a breast cancer patient based on Gene AST tables the number of gene fusion events.

Step 7 Read alignments

Candidate gene fusions

Template index

Distant spliced reads Alternative within same gene splicing Ensembl candidates annotation w o 2014/071279 A2 1I 11 II I 1 I 1 II II III II I llll III II I II

Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) GENE FUSIONS AND ALTERNATIVELY SPLICED JUNCTIONS ASSOCIATED WITH BREAST CANCER

SEQUENCE LISTING [0000] The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on October 24, 2013, is named GHI-0056-PCT_SL.txt and is 1,261,876 bytes in size. FIELD OF THE INVENTION [0001] The present invention relates to gene fusions and genes comprising alternative spliced junctions associated with breast cancer. The present invention also relates to methods of identifying gene fusions and genes comprising alternative spliced junctions in samples obtained from a patient with cancer. Furthermore, the present invention relates to method of predicting the prognosis of a patient with breast cancer based on the number of gene fusion events. INTRODUCTION [0002] Genomic aberrations resulting in gene fusions and alternatively spliced genes play an important role in cancer. Gene fusions, for example, have been estimated to account for about 20% of human cancer morbidity. Mitelman et al., Nature Reviews Cancer 7:233-245 (2007). Gene fusions are hybrids created by joining two previously separate genes via genomic aberrations such as translocations, deletions, and inversions, or trans-splicing between precursor mRNAs. Gene fusions may up-regulate expression of oncogenic genes by fusing a strong promoter to an oncogene. The first gene fusion identified in human neoplasia was BCR-ABL1 in chronic myelogenous leukemia (CML). The protein resulting from this fusion exhibits constitutive tyrosine kinase activity. Discovery of BCR-ABL1 led to development of a targeted treatment for CML using the tyrosine kinase inhibitor imatinib, which was approved in 2001. Druker et al., New England Journal of Medicine 344:1038- 1042 (2001). Most of the known gene fusions have been found in hematological disorders; however, with the advent of next-generation sequencing technology, rare recurrent gene fusion events have been identified in common solid tumors. See Kohno et al., (2012) Nature Medicine 18: 375-377 (2012); Takeuchi et al., Nature Medicine 18: 378-381 (2012); Lipson et al., Nature Medicine, 18: 382-384 (2012); and Ju, et al., Genome Res., 22: 436-445 (2012). [0003] In cancer, aberrantly spliced pre-mRNAs escape the quality control mechanisms within cells (e.g., the nonsense mediated mRNA decay pathway) and are, therefore, translated into aberrant proteins. He et al., PLoS ONE 4(3):e4732 (2009). For example, alternative splicing is known to be related to the pathogenesis of colon cancer and has been described to occur in lung adenocarcinoma. Seo et al., Genome Research 1-11 (Oct. 2012). [0004] Transcriptome sequencing enables detection of transcriptional variants such as gene fusions and alternative splicing events. Current methods, such as ChimeranScan (Robinson, et al., Nature Medicine 17: 1646-1651 (2011)), SnowShoes-FTD (Asmann et al., Cancer Res, 72: 1921-1928 (2012)), GSTRUCT-fusions (Seshagiri,S. et al., Nature 488: 660-664 (2012)), and GFP (Ju et al., Genome Res., 22: 436-445 (2012)), use paired-end data obtained from fresh frozen tissue samples to detect gene fusions. Other methods, such as TopHat-Fusion (Kim and Salzberg, Genome Biol 12: R72 (2011)), FusionMap (Ge et al. Bioinformatics, 27: 1922-1928 (2011)), and FusionFinder (Francis et al. PLoS One, 7(6):e39987 (2012)) can use single-end data from cell lines or fresh frozen tissue samples to detect gene fusions. [0005] Because standard clinical practices include generating formalin-fixed, paraffin-embedded (FFPE) tissue samples from biopsies and surgical resections, FFPE samples provide an enormous repository of information for cancer research. Nonetheless, current methods are not well suited for investigating RNA from FFPE samples as the RNA from such samples is often degraded and libraries generated from those samples have low complexity and small insert sizes. [0006] The present bioinformatics approaches identify gene fusions and alternative spliced junctions from FFPE RNA-sequencing datasets at base-pair resolution. SUMMARY [0007] A bioinformatics approach was developed to identify gene fusion junctions using FFPE RNA-sequencing datasets. The present invention provides gene fusion junctions that are present in breast cancer tissue samples. These gene fusions are provided in Tables A and B. The present invention also provides a bioinformatics approach to identify alternative spliced junctions. The present invention provides alternative spliced junctions that are present in breast cancer tissue samples. These alternative spliced junctions are present in Table 5. [0008] The present invention accommodates the use of archived paraffin- embedded biopsy material for assay of gene fusion transcripts, and therefore is compatible with the most widely available type of biopsy material. It is also compatible with other different methods of tumor tissue harvest, for example, via core biopsy or fine needle aspiration. [0009] A multiplexed, whole genome sequencing methodology was used to enable whole transcriptome-wide gene fusion and alternative spliced junction discovery using low amounts of FFPE tissue. The methods described herein support the use of single end or paired end sequence reads. [0010] In one aspect, the invention provides a method for identifying a gene fusion in a biological sample obtained from a patient with cancer. The method comprises obtaining a plurality of reads from RNA sequencing of the biological sample. The read is then mapped to the human genome. Next, the method comprises determining whether the read comprises a distant spliced junction and selecting the read comprising a distant spliced junction. A candidate gene fusion comprising the distant spliced junction is then identified. The method also comprises creating a first set of templates for the candidate gene fusion. The first set of templates comprises: (1) a fusion template comprising 50 base pairs (bp) of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (2) a donor template comprising 50 bp of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a discarded region of an donor gene, (3) an acceptor template comprising 50 bp of exonic sequence of a discarded region of a acceptor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (4) a donor genomic template comprising 50 bp upstream genomic sequence of a donor splicing site and 50 bp downstream genomic sequence of a donor splicing site, and (5) an acceptor genomic template comprising 50 bp upstream genomic sequence of an acceptor splicing site and 50 bp downstream genomic sequence of an acceptor splicing site. The first set of templates is used to filter false positives and provide accurate read alignment information. A candidate gene fusion is removed if any of the first template set sequences are identical, but map to different genes in the human genome. Next, a second set of templates is created. The second set of templates comprises (a) a fusion template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (b) a donor template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a discarded region of an donor gene, (c) an acceptor template comprising 150 bp of exonic sequence of a discarded region of a acceptor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (d) a donor genomic template comprising 150 bp upstream genomic sequence of a donor splicing site and 150 bp downstream genomic sequence of a donor splicing site, and (e) an acceptor genomic template comprising 150 bp upstream genomic sequence of an acceptor splicing site and 150 bp downstream genomic sequence of an acceptor splicing site. The second set of templates is also used to filter false positives by determining the homology between templates (b) and (c) and between templates (d) and (e) and removing the candidate gene fusion if templates (b) and (c) are homologous or if templates (d) and (e) are homologous. Next, a read obtained from RNA sequencing of the biological sample is aligned to the first set of templates and the read that maps to the fusion template of the first set of templates is selected. [0011] In some embodiments, a gene fusion is identified by a candidate gene fusion having at least two non-duplicate reads that map to the fusion template of the first set of templates. [0012] In other embodiments, a gene fusion is identified by a candidate gene fusion having one non-duplicate read that maps to the fusion template of the first set of templates. The method then comprises determining and comparing the expression levels of the exons and introns of the preserved regions of the donor gene and the acceptor gene to the expression levels of the exons and introns of the discarded regions of the donor gene and the acceptor gene. A gene fusion is then identified as having increased expression levels of exons and introns of the preserved regions of the donor gene and the acceptor gene compared to the expression levels of the exons and introns of the discarded regions of the donor gene and the acceptor gene. [0013] In another aspect, the present invention provides a method for predicting the presence of a gene fusion in a biological sample obtained from a patient with cancer. The method comprises identifying a gene fusion according to any of claims 1-3 in a first biological sample. Next, a second biological sample that does not have reads that map to the gene fusion is obtained. Then, the method comprises determining in the second biological sample the expression levels of exons and introns of preserved and discarded regions of a donor gene and an acceptor gene of the gene fusion identified in any of claims 1-3. The expression level of the second biological sample is compared to the expression levels of the first biological sample. The presence of the gene fusion in the second biological sample is predicted based on having a similar expression profile compared to the first biological sample. In yet another aspect, the invention provides a method of predicting a likelihood of poor prognosis in a breast cancer patient. Gene fusion events in a breast tumor sample from the patient are identified and the number of gene fusion events in the breast tumor sample is determined. The presence of three or more gene fusion events is positively correlated with an increased likelihood of poor prognosis. [0014] In a further aspect, the present invention provides a method of identifying an alternatively spliced junction in a biological sample obtained from a patient with cancer. The method comprises obtaining a read from RNA sequencing of the biological sample. Next, the read is mapped to the human genome. It is then determined whether the read comprises a distant spliced junction and the read that comprises the distant spliced junction is selected. It is next determined whether the distant spliced junction is present in a single gene. The distant spliced junction that is present in a single gene is selected. In some embodiments, the method further comprises preparing a report based on the identification of an alternative spliced junction. [0015] In still a further aspect, the present invention provides a method for predicting a risk of recurrence of breast cancer. The method comprises determining the presence of an alternative spliced junction in a breast cancer tumor sample obtained from said patient. The alternative spliced junction is selected from Table 5. The presence of junction - chr3:196118684_-chr3:196129890 in UBXN, junction -chrl2:24366277_-chrl2:24048958 in SOX5, junction -chr9:114148657_-chr9: 114154104 in KIAA0368, junction +chrl8:39629569_+chrl8:39623697 in PIK3C3, or junction +chrl:155695810_chrl:155695173 is correlated with an decreased risk of recurrence, and wherein the presence of junction -chr2:99786013_-chr2:99787892 in MITD1 is correlated with an increased risk of recurrence. The presence of the alternative spliced junction can be determined by whole transcriptome sequencing or reverse transcriptase polymerase chain reaction (RT-PCR). [0016] In some embodiments, an isolated polynucleotide comprises a gene fusion, wherein the isolated polynucleotide comprises a sequence selected from SEQ ID NO: 1 to SEQ ID NO: 100 is provided [0017] In other embodiments, an isolated polynucleotide comprises an alternative spliced junction selected from -chrl2:24366277_-chrl2:24048958; -chr9:114148657_- chr9: 114154104; +chrl8:39629569_+chrl 8:39623697; +chrl:155695810_chrl: 155695 173; and -chr2:99786013_-chr2:99787892 is provided. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] FIGURE 1A shows an overview of the bioinformatics method for identifying a gene fusion and the bioinformatics method for identifying alternatively spliced genes from RNA sequencing data. FIGURE IB shows classification of candidate fusions into 3 tiers based on the levels of supporting evidence. [0019] FIGURE 2 depicts the individual templates present in the five template set described in Example 3 : (1) fusion template; (2) donor template; (3) acceptor template; (4) donor genomic template; and (5) donor acceptor template. Figure 2 also provides the equation used to calculate the interrupt ratio (IR). [0020] FIGURE 3 (Fig. 3.1 - Fig. 3.105) shows the sequences of the 100 bp five template set (fusion template, donor template, acceptor template, donor genomic template, and acceptor genomic template) and any supporting reads for the gene fusion candidates identified using the bioinformatics approach. Sample information appears below the corresponding sequence information. FIGURE 3 discloses SEQ ID NOS 358-3278, respectively, in order of appearance. [0021] FIGURE 4 (Fig. 4.1 - Fig. 4.105) shows exon and intron expression data from the candidate gene fusions. The identifiers beginning with "X" represent patient samples identified to be positive for the indicated fusion. For example, in Figure 4.1, patient sample X I 11TTAGGC_7 was identified as positive for the ACACA_MSI2 fusion. [0022] The top panel shows a scatter plot of the expression data. The x-axis shows the number of normalized counts for the indicated fusion donor and the y-axis shows the number of normalized counts for the indicated fusion acceptor. The closed circles represent samples that are positive for the indicated fusion and the open circles shows the remaining samples in the cohort that are negative for the fusion. [0023] The middle panel shows a bar plot of the expression of the exons and introns of the indicated fusion donor. The x-axis shows the relative genomic location of the donor's exons and introns and the y-axis shows the number of normalized counts by length. The vertical line separates the donor exons and introns into those that preserved in the fusion (black bars) and those that are discarded from the fusion (gray bars). As shown on the x-axis, the symbol "d" indicates that the exon or intron is a donor exon or intron; the symbol "1" indicates that the exon or intron is located to the left of the vertical line separating discarded and preserved exons and introns; the symbol "r" indicates that the exon or intron is located to the right of the vertical line separating discarded and preserved exons and introns. [0024] The bottom panel shows a bar plot of the expression of the exons and introns of the indicated fusion acceptor. The x-axis shows the relative genomic location of the acceptor's exons and introns and the y-axis shows the number of normalized counts by length. The vertical line separates the acceptor exons and introns into those that preserved in the fusion (black bars) and those that are discarded from the fusion (gray bars). As shown on the x-axis, the symbol "a" indicates that the exon or intron is an acceptor exon or intron; the symbol "1" indicates that the exon or intron is located to the left of the vertical line separating discarded and preserved exons and introns; the symbol "r" indicates that the exon or intron is located to the right of the vertical line separating discarded and preserved exons and introns. [0025] FIGURE 5A shows the distributions of block age, cancer relapse and ER status according to fusion number categories in Providence and Rush cohorts. The archived block age was plotted as mean and standard deviation for each category. ER status was assessed by immunohistochemistry. The patient number for each category was labeled accordingly. [0026] FIGURE 5B shows Kaplan-Meier plots of each fusion number category demonstrating patients with multiple fusions had poor prognosis in Providence, and a similar trend existed in Rush. The log-rank p-values were indicated in Kaplan-Meier plots. [0027] FIGURE 5C shows that the differentially expressed genes between multiple fusion samples versus no fusion samples in Providence were mapped to the Reactome FI database and clustered into five core sub-modules via linker proteins (in grey shaded rectangles) by the Reactome FI Cytoscape Plugin. The connected 84 genes are referred as the fusion gene signature. Nodes were manually arranged to display the sub- modules properly. Edges displayed FI direction attribute values as the following, "->" for activating/catalyzing, for inhibition, "-" for FIs extracted from complexes or inputs, and "—" for predicted FIs. [0028] FIGURE 5D shows fusion signature indexes plotted for each of the fusion number categories in Providence and Rush. The fusion signature index is the average expression levels of 84 fusion gene signatures as shown in Figure 5C. The base counts of each signature gene were normalized by library size then scaled across the patient cohort before averaged in the signature index. The p-values were derived from Wilcoxon tests. [0029] FIGURE 6 depicts Kaplan-Meier plots of patient subsets of Providence or Rush patients as a function of fusion numbers, segregated by block age. Either upper three quantiles or lower three quantiles based on block age were selected to examine the effect of the block ages on the disease outcome. The log-rank p-values are displayed. [0030] FIGURE 7 depicts Venn diagrams between differentially expressed genes from samples segregated by fusion numbers and ER status in Providence. The additive model of edgeR was used only for DE analysis between multiple fusion samples versus no fusion samples. The up-regulated and down-regulated gene numbers were labeled with each differential expression analysis. The overlapped gene numbers combined from both up- regulated and down-regulated genes were labeled according to each comparison. A. ER+ samples contribute to fusion gene signatures more than ER samples in Providence, consistent with the expression evidence from heatmaps. The overlapping genes between fusion gene signatures and differentially expressed genes due to ER status difference in both multiple fusion and no fusion groups are small. [0031] FIGURE 8 shows the expression level of AKAP12 in patients of the Rush cohort. [0032] FIGURE 9 shows Protein domains of fusion ESR1 ->AKAP12 are illustrated based on UniProt database (www.uniprot.org). The red vertical line indicates the fusion position on the corresponding protein. The amino acid length and amino acid positions of each fusion position are labeled on the top of each protein. A. The protein domains of ESR1 protein P03372. B. The protein domains of AKAP12 protein Q02952. C. The protein domains of two predicted fusion proteins ESR1->AKAP12. The one amino acid insertion generated from the fusion event is labeled on each fusion protein.

DETAILED DESCRIPTION [0033] Before the present invention and specific exemplary embodiments of the invention are described, it is to be understood that this invention is not limited to particular embodiments described, as such may, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting, since the scope of the present invention will be limited only by the appended claims. [0034] Where a range of values is provided, it is understood that each intervening value, to the tenth of the unit of the lower limit unless the context clearly dictates otherwise, between the upper and lower limit of that range and any other stated or intervening value in that stated range is encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included in the smaller ranges is also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either both of those included limits are also included in the invention. [0035] As used herein and in the appended claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "an RNA transcript" includes a plurality of such RNA transcripts. [0036] Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. For example, Singleton et al., Dictionary of Microbiology and Molecular Biology 2nd ed., J. Wiley & Sons (New York, NY 1994), provide one skilled in the art with a general guide to many of the terms used in the present application. [0037] Additionally, the practice of the present invention will employ, unless otherwise indicated, conventional techniques of molecular biology (including recombinant techniques), microbiology, cell biology, and biochemistry, which are within the skill of the art. Such techniques are explained fully in the literature, such as, "Molecular Cloning: A Laboratory Manual", 2nd edition (Sambrook et al., 1989); "Oligonucleotide Synthesis" (M.J. Gait, ed., 1984); "Animal Cell Culture" (R.I. Freshney, ed., 1987); "Methods in Enzymology" (Academic Press, Inc.); "Handbook of Experimental Immunology", 4th edition (D.M. Weir & C.C. Blackwell, eds., Blackwell Science Inc., 1987); "Gene Transfer Vectors for Mammalian Cells" (J.M. Miller & M.P. Calos, eds., 1987); "Current Protocols in Molecular Biology" (F.M. Ausubel et al., eds., 1987); and "PCR: The Polymerase Chain Reaction", (Mullis et al., eds., 1994). [0038] One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. Indeed, the present invention is in no way limited to the methods and materials described. For purposes of the present invention, the following terms are defined below. [0039] The term "annotate" refers to adding biological information to a genome sequence. [0040] The terms "cancer" and "cancerous" refer to or describe the physiological condition in mammals that is typically characterized by unregulated cell growth. Examples of cancer include but are not limited to, breast cancer, colon cancer, lung cancer, prostate cancer, hepatocellular cancer, gastric cancer, pancreatic cancer, cervical cancer, ovarian cancer, liver cancer, bladder cancer, cancer of the urinary tract, thyroid cancer, renal cancer, carcinoma, melanoma, and brain cancer. [0041] The term "correlates" or "correlating" as used herein refers to a statistical association between instances of two events, where events may include numbers, data sets, and the like. For example, when the events involve numbers, a positive correlation (also referred to herein as a "direct correlation") means that as one increases, the other increases as well. A negative correlation (also referred to herein as an "inverse correlation") means that as one increases, the other decreases. The present invention provides gene fusions and alternative spliced junctions which may be correlated with a particular outcome measure. For example, the presence of a gene fusion or an alternative spliced junction may be positively correlated with a likelihood of a good clinical outcome for the patient, such as an increased likelihood of long-term survival without recurrence and/or a positive response to a chemotherapy, and the like. Such a positive correlation may be demonstrated statistically in various ways, e.g. by a low hazard ratio. In another example, the presence of a gene fusion or an alternative spliced junction may be negatively correlated with a likelihood of good clinical outcome for the patient. In this case, for example, the patient may have a decreased likelihood of long-term survival without recurrence of the cancer and/or a positive response to a chemotherapy, and the like. Such a negative correlation indicates that the patient likely has a poor prognosis or will respond poorly to a chemotherapy, and this may be demonstrated statistically in various ways, e.g., by a high hazard ratio. [0042] As used herein, the term "exon" refers to any segment of an interrupted gene that is represented in the mature RNA product (B. Lewin. Genes IV Cell Press, Cambridge Mass. 1990). As used herein, the terms "intron" and "intronic sequence" refer to any non-coding region found within genes. [0043] The term "expression product" as used herein refers to an expression product of a coding RNA transcript. Thus, the term refers to a polypeptide or protein. [0044] As used herein, the term "intergenic region" refers to a stretch of DNA or RNA sequences located between clusters of genes that contain few or no genes. Intergenic regions are different from intragenic regions (or "introns"), which are non-coding regions that are found between exons within genes. An intergenic region may be comprised of one or more "intergenic sequences." [0045] As used herein, the term "gene fusion" refers to a chimeric molecule derived from two separate genes - a donor gene and an acceptor gene. The donor gene is generally located upstream of the acceptor gene. The regions of the donor gene and the acceptor gene that are present in the gene fusion are referred to herein as a "preserved region" of the donor gene and a "preserved region" of the acceptor gene, respectively. The regions of the donor gene and the acceptor gene that are not present in the gene fusion are referred to herein as a "discarded region" of the donor gene and a "discarded region" of the acceptor gene, respectively. A gene fusion may arise from a chromosomal aberration, such as a translocation, deletion, or inversion, within a chromosome or between chromosomes. A gene fusion may result in an expression product with a new or different function compared to the fusion partners. Alternatively, a proto-oncogene may be fused to a strong promoter, resulting in expression of an oncogene. A gene fusion is recurrent when it is present in samples from two or more patients with the same type of cancer, for example, breast cancer. [0046] As used herein, the term "homology" with regard to template sequences, refers to the degree of similarity between two sequences. In some embodiments, a 300 bp donor template and a 300 bp acceptor template are homologous if they share sequence identity of more than 14 bp. In other embodiments, a 300 bp donor genomic template and a 300 bp acceptor genomic template are homologous if they share sequence identity of more than 14 bp. [0047] As used herein, the term "isolated" refers to a molecule that is separated from other constituents. For example, an isolated DNA molecule may be cleaved from genomic DNA or synthesized to include a portion of a naturally occurring DNA molecule. Isolated DNA is a free-standing portion of the larger, natural DNA molecule. Isolated DNA molecules, therefore, are not naturally occurring DNA molecules or native DNA molecules. [0048] As used herein, the term "level" refers to qualitative or quantitative determination of the number of reads of exons and introns in the genes that comprise a gene fusion. An exon or an intron exhibits an "increased level" when the level of the exon or intron is higher in a first sample, such as in a preserved acceptor or donor region of a gene fusion, than in a second sample, such as in a discarded acceptor or donor region of a gene fusion. [0049] The term "long-term" survival as used herein refers to survival for at least 3 years. In other embodiments, it may refer to survival for at least 5 years, or for at least 10 years following surgery or other treatment. [0050] As used herein, the term "pathology" of cancer includes all phenomena that comprise the well-being of the patient. This includes, without limitation, abnormal or uncontrollable cell growth, metastasis, interference with the normal functioning of neighboring cells, release of cytokines or other secretory products at abnormal levels, suppression or aggravation of inflammatory or immunological response, neoplasia, premalignancy, malignancy, invasion of surrounding or distant tissues or organs, such as lymph nodes. [0051] A "patient response" may be assessed using any endpoint indicating a benefit to the patient, including, without limitation, (1) inhibition, to some extent, of tumor growth, including slowing down and complete growth arrest; (2) reduction in the number of tumor cells; (3) reduction in tumor size; (4) inhibition (i.e., reduction, slowing down or complete stopping) of tumor cell infiltration into adjacent peripheral organs and/or tissues; (5) inhibition (i.e. reduction, slowing down or complete stopping) of metastasis; (6) enhancement of anti-tumor immune response, which may, but does not have to, result in the regression or rejection of the tumor; (7) relief, to some extent, of one or more symptoms associated with the cancer; (8) increase in the length of survival following treatment; and/or (9) decreased mortality at a given point of time following treatment. [0052] The term "polynucleotide" when used in singular or plural, generally refers to any polyribonucleotide or polydeoxribonucleotide, which may be unmodified RNA or DNA or modified RNA or DNA. Thus, for instance, polynucleotides as defined herein include, without limitation, single- and double-stranded DNA, DNA including single- and double-stranded regions, single- and double-stranded RNA, and RNA including single- and double-stranded regions, hybrid molecules comprising DNA and RNA that may be single- stranded or, more typically, double-stranded or include single- and double-stranded regions. In addition, the term "polynucleotide" as used herein refers to triple-stranded regions comprising RNA or DNA or both RNA and DNA. The strands in such regions may be from the same molecule or from different molecules. The regions may include all of one or more of the molecules, but more typically involve only a region of some of the molecules. One of the molecules of a triple-helical region often is an oligonucleotide. The term "polynucleotide" specifically includes cDNAs. The term includes DNAs (including cDNAs) and RNAs that contain one or more modified bases. Thus, DNAs or RNAs with backbones modified for stability or for other reasons are "polynucleotides" as that term is intended herein. Moreover, DNAs or RNAs comprising unusual bases, such as inosine, or modified bases, such as tritiated bases, are included within the term "polynucleotides" as defined herein. In general, the term "polynucleotide" embraces all chemically, enzymatically and/or metabolically modified forms of unmodified polynucleotides, as well as the chemical forms of DNA and RNA characteristic of viruses and cells, including simple and complex cells. [0053] The term "prognosis" as used herein, refers to the prediction of the likelihood of cancer-attributable death or progression, including recurrence, metastatic spread, and drug resistance, of neoplastic disease, such as breast cancer. The term "prediction" is used herein to refer to the likelihood that a patient will respond either favorably or unfavorably to a drug or set of drugs, and also the extent of those responses, or that a patient will survive, following surgical removal of the primary tumor and/or chemotherapy for a certain period of time without cancer recurrence. The methods of the present invention can be used clinically to make treatment decisions by choosing the most appropriate treatment modalities for any particular patient. The methods of the present invention are tools in predicting if a patient is likely to respond favorably to a treatment regimen, such as surgical intervention, chemotherapy with a given drug or drug combination, and/or radiation therapy, or whether long-term survival of the patient without cancer recurrence is likely, following surgery and/or termination of chemotherapy or other treatment modalities. [0054] The term "recurrence," as used herein, refers to local or distant (metastasis) recurrence of cancer. For example, breast cancer can come back as a local recurrence (in the treated breast or near the tumor surgical site) or as a distant recurrence in the body. The most common sites of breast cancer recurrence include the lymph nodes, bones, liver, or lungs. [0055] As used herein, the term "RefSeq RNA" refers to an RNA that can be found in the Reference Sequence (RefSeq) database, a collection of publicly available nucleotide sequences and their protein products built by the National Center for Biotechnology Information (NCBI). The RefSeq database provides an annotated, non- redundant record for each natural biological molecule (i.e. DNA, RNA or protein) included in the database. Thus, a sequence of a RefSeq RNA is well-known and can be found in the RefSeq database at http://www.ncbi.nlm.nih.gov/RefSeq/. See also Pruitt et al., Nucl. Acids Res. 33(Supp 1):D501-D504 (2005). Accession numbers for donor and acceptor RefSeq are provided in Table A. [0056] As used herein, the term "RNA transcript" refers to the RNA transcription product of DNA and includes coding and non-coding RNA transcripts. RNA transcripts include, for example, mRNA, an unspliced RNA, a splice variant mRNA, a microRNA, fragmented RNA, long intergenic non-coding RNAs (lincRNAs), intergenic RNA sequences or regions, and intronic RNAs. [0057] The terms "read" and "sequence read" are used interchangeably herein to refer to sequence information obtained from an RNA sequencing experiment. A read may comprise, for example, 50 bases to 150 bases, 50 bases to 100 bases, 50 bases to 55 bases, 55 bases to 60 bases, 60 bases to 65 bases, 65 bases to 70 bases, 70 bases to 75 bases, 75 bases to 80 bases, 80 bases to 85 bases, 85 bases to 90 bases, 90 bases to 95 bases, 95 bases to 100 bases, 100 bases to 105, 105 bases to 110, 110 bases to 115, 115 bases to 120, 120 bases to 125, 125 bases to 130, 130 bases to 135, 135 bases to 140, 140 bases to 145, or 145 bases to 150 bases. A read may be a single read or a paired-end read. A single read refers to a read that is sequenced from one end. A paired-end read refers to a read that is sequenced from both ends. [0058] As used herein, the term "splicing" refers to the process of removing introns and joining exons from pre-mRNA to generate mRNA. The terms "splice site" and "splice junction" are used interchangeably to refer to a region where a splicing event takes place, for example, at an exon-intron junction in a pre-mRNA molecule. For example, a slice donor site may be present at the 5' end of an intron and a splice acceptor site may be present at the 3' end of an intron. As used herein, a "distant spliced site" includes sites used in splicing events that occur between different genes or chromosomes. Distant splicing events may also include splicing events occurring within the same gene, but in the opposite transcription direction. Distant splicing events may include translocations, inversions, and the like. As used herein, "alternative splicing" refers to a process whereby identical pre- mRNA molecules are spliced in various ways to yield different mRNA molecules. The different mRNA molecules may be translated into different protein isoforms. [0059] In some embodiments, the alternative spliced junction is present UBXN7, SOX5, KIAA0368, PIKC3C, DAP3, or MITD1. In other embodiments, the alternative spliced junction within UBXN7 comprises the junction -chr3:196118684_-chr3:196129890; the alternative spliced junction within SOX5 comprises the junction -chrl2:24366277_- chrl2:24048958; the alternative spliced junction within KIAA0368 comprises the junction - chr9:114148657_-chr9: 114154104; the alternative spliced junction within PIK3C3 comprises the junction +chrl8:39629569_+chrl8:39623697; the alternative spliced junction within DAP3 comprises the junction +chrl:155695810_chrl:155695173; and the alternative spliced junction within MITD1 comprises the junction -chr2:99786013_-chr2:99787892. [0060] The terms "subject," "individual," and "patient" are used interchangeably herein to refer to a mammal being assessed for treatment and/or being treated. In an embodiment, the mammal is a human. The terms "subject," "individual," and "patient" thus encompass individuals having cancer (e.g., breast cancer), including those who have undergone or are candidates for resection (surgery) to remove cancerous tissue. [0061] As used herein, the term "surgery" applies to surgical methods undertaken for removal of cancerous tissue, including mastectomy, lumpectomy, lymph node removal, sentinel lymph node dissection, prophylactic mastectomy, prophylactic ovary removal, cryotherapy, and tumor biopsy. The tumor samples used for the methods of the present invention may have been obtained from any of these methods. [0062] As used herein, the term "template" refers to a nucleotide sequence against which another nucleotide sequence may be compared. The templates used in the methods of the present invention include (1) a fusion template comprising 50 orl50 bp of exonic sequence of a preserved region of a donor gene and 50 orl 50 bp of exonic sequence of a preserved region of an acceptor gene, (2) a donor template comprising 50 orl 50 bp of exonic sequence of a preserved region of a donor gene and 50 orl 50 bp of exonic sequence of a discarded region of an donor gene, (3) an acceptor template comprising 50 orl 50 bp of exonic sequence of a discarded region of a acceptor gene and 50 orl 50 bp of exonic sequence of a preserved region of an acceptor gene, (4) a donor genomic template comprising 50 orl 50 bp upstream genomic sequence of a donor splicing site and 50 orl 50 bp downstream genomic sequence of a donor splicing site, and (5) an acceptor genomic template comprising 50 orl 50 bp upstream genomic sequence of an acceptor splicing site and 50 orl 50 bp downstream genomic sequence of an acceptor splicing site. In some embodiments, the method comprises determining the homology between various templates. In other embodiments, the method comprises aligning a read obtained from RNA sequencing of a biological sample to the templates and selecting the read that maps to the fusion template. [0063] The term "tumor" as used herein, refers to all neoplastic cell growth and proliferation, whether malignant or benign, and all pre-cancerous and cancerous cells and tissues. [0064] The term "tumor sample" as used herein refers to a sample comprising tumor material obtained from a cancer patient. The term encompasses tumor tissue samples, for example, tissue obtained by surgical resection and tissue obtained by biopsy, such as for example, a core biopsy or a fine needle biopsy. In a particular embodiment, the tumor sample is a fixed, wax-embedded tissue sample, such as a formalin-fixed, paraffin-embedded tissue sample. Additionally, the term "tumor sample" encompasses a sample comprising tumor cells obtained from sites other than the primary tumor, e.g., circulating tumor cells. The term also encompasses cells that are the progeny of the patient's tumor cells, e.g. cell culture samples derived from primary tumor cells or circulating tumor cells. The term further encompasses samples that may comprise protein or nucleic acid material shed from tumor cells in vivo, e.g., bone marrow, blood, plasma, serum, and the like. The term also encompasses samples that have been enriched for tumor cells or otherwise manipulated after their procurement and samples comprising polynucleotides and/or polypeptides that are obtained from a patient' s tumor material. [0065] As used herein, "whole transcriptome sequencing" refers to the use of high throughput sequencing technologies to sequence the entire transcriptome in order to get information about a sample's RNA content. Whole transcriptome sequencing can be done with a variety of platforms for example, the Genome Analyzer or HiSeq 2000/2500 (Illumina, Inc., San Diego, CA) and the SOLiD™ Sequencing System (Life Technologies, Carlsbad, CA). However, any platform useful for whole transcriptome sequencing may be used. [0066] The term "RNA-Seq" or "transcriptome sequencing" or "RNA sequencing" refers to sequencing performed on RNA (or cDNA) instead of DNA, where typically, the primary goal is to measure expression levels, detect fusion transcripts, alternative splicing, and other genomic alterations that can be better assessed from RNA. RNA-Seq includes whole transcriptome sequencing as well as target specific sequencing. [0067] The term "computer-based system," as used herein, refers to the hardware means, software means, and data storage means used to analyze information. The minimum hardware of a patient computer-based system comprises a central processing unit (CPU), input means, output means, and data storage means. A skilled artisan can readily appreciate that many of the currently available computer-based system are suitable for use in the present invention and may be programmed to perform the specific measurement and/or calculation functions of the present invention. [0068] To "record" data, programming or other information on a computer readable medium refers to a process for storing information, using any such methods as known in the art. Any convenient data storage structure may be chosen, based on the means used to access the stored information. A variety of data processor programs and formats can be used for storage, e.g. word processing text file, database format, etc. [0069] A "processor" or "computing means" references any hardware and/or software combination that will perform the functions required of it. For example, any processor herein may be a programmable digital microprocessor such as available in the form of an electronic controller, mainframe, server or personal computer (desktop or portable). Where the processor is programmable, suitable programming can be communicated from a remote location to the processor, or previously saved in a computer program product (such as a portable or fixed computer readable storage medium, whether magnetic, optical or solid state device based). For example, a magnetic medium or optical disk may carry the programming, and can be read by a suitable reader communicating with each processor at its corresponding station. [0070] The present invention provides gene fusions and alternative spliced junctions that are associated with breast cancer. These gene fusions are listed in Tables A and B and the alternative spliced junctions are provided in Table 5. The present invention also provides a method for identifying gene fusions and a method for identifying alternative spliced junctions in a biological sample obtained from a patient with cancer. The present invention further provides a method for predicting a gene fusion in a biological sample obtained from a patient with cancer. [0071] The gene fusions and alternative spliced junctions and associated information provided by the present invention also have utility in the development of therapies to treat cancers and screening patients for inclusion in clinical trials. The gene fusions and alternative spliced junctions and associated information may further be used to design or produce a reagent that modulates the level or activity of the gene fusion and alternative spliced junction. Such reagents may include, but are not limited to, a drug, an antisense RNA, a small inhibitory RNA (siRNA), a ribozyme, a small molecule, a monoclonal antibody, and a polyclonal antibody. [0072] In various embodiments of the methods of the present invention, various technological approaches are available for determining the presence of gene fusions or alternative spliced junctions, including, without limitation, whole transcriptome sequencing, RT-PCR, microarrays, and serial analysis of gene expression (SAGE), which are described in more detail below.

CORRELATING THE PRESENCE OF A GENE FUSION OR AN ALTERNATIVESPLICED JUNCTION

To A CLINICAL OUTCOME [0073] One skilled in the art will recognize that there are many statistical methods that may be used to determine whether there is a correlation between an outcome of interest (e.g., likelihood of survival) and the presence of a gene fusion or an alternative spliced junction. This relationship can be presented as a continuous recurrence score (RS), or patients may be stratified into risk groups (e.g., low, intermediate, high). For example, a Cox proportional hazards regression model may fit to a particular clinical endpoint (e.g., RFI, DFS, OS). One assumption of the Cox proportional hazards regression model is the proportional hazards assumption, i.e. the assumption that effect parameters multiply the underlying hazard. Assessments of model adequacy may be performed including, but not limited to, examination of the cumulative sum of martingale residuals. One skilled in the art would recognize that there are numerous statistical methods that may be used (e.g., Royston and Parmer (2002), smoothing spline, etc.) to fit a flexible parametric model using the hazard scale and the Weibull distribution with natural spline smoothing of the log cumulative hazards function, with effects for treatment (chemotherapy or observation) and RS allowed to be time-dependent. (See, e.g., P. Royston, M. Parmer, Statistics in Medicine 21(15:2175-2197 (2002).) [0074] In an exemplary embodiment, power calculations are carried out for the Cox proportional hazards model with a single non-binary covariate using the method proposed by F. Hsieh and P. Lavori, Control Clin Trials 21:552-560 (2000) as implemented in PASS 2008.

METHODS OF ASSAYING GENE FUSIONS AND ALTERNATIVESPLICED JUNCTIONS

[0075] Methods of assaying gene fusions and alternative spliced junctions include methods based on sequencing of polynucleotides, methods based on hybridization analysis of polynucleotides, and proteomics- based methods. Representative methods for sequencing- based analysis include Massively Parallel Sequencing (see e.g., Tucker et al., The American J. Human Genetics 85:142-154, 2009) and Serial Analysis of Gene Expression (SAGE). Exemplary methods known in the art for the quantification of mRNA expression in a sample include northern blotting and in situ hybridization (Parker & Barnes, Methods in Molecular Biology 106:247-283 (1999)); RNAse protection assays (Hod, Biotechniques 13:852-854 (1992)); and PCR-based methods, such as reverse transcription polymerase chain reaction (RT-PCR) (Weis et al., Trends in Genetics 8:263-264 (1992)). Antibodies may be employed that can recognize sequence-specific duplexes, including DNA duplexes, RNA duplexes, and DNA-RNA hybrid duplexes or DNA-protein duplexes. Nucleic Acid Sequencin2-Based Methods [0076] Nucleic acid sequencing technologies are suitable methods for expression analysis. The principle underlying these methods is that the number of times a cDNA sequence is detected in a sample is directly related to the relative RNA levels corresponding to that sequence. These methods are sometimes referred to by the term Digital Gene Expression (DGE) to reflect the discrete numeric property of the resulting data. Early methods applying this principle were Serial Analysis of Gene Expression (SAGE) and Massively Parallel Signature Sequencing (MPSS). See, e.g., S. Brenner, et al., Nature Biotechnology 18(6):630-634 (2000). [0077] More recently, the advent of "next-generation" sequencing technologies has made DGE simpler, higher throughput, and more affordable. As a result, more laboratories are able to utilize DGE to screen the expression of more nucleic acids in more individual patient samples than previously possible. See, e.g., J. Marioni, Genome Research 18(9):1509-1517 (2008); R. Morin, Genome Research 18(4):610-621 (2008); A. Mortazavi, Nature Methods 5(7):621-628 (2008); N. Cloonan, Nature Methods 5(7):613-619 (2008). Massively parallel sequencing methods have also enabled whole genome or transcriptome sequencing, allowing the analysis of not only coding but also non-coding sequencees. As reviewed in Tucker et al., The American J. Human Genetics 85:142-154 (2009), there are several commercially available massively parallel sequencing platforms, such as the Illumina Genome Analyzer or HiSeq 2000/2500 (Illumina, Inc., San Diego, CA), Applied Biosystems SOLiD™ Sequencer (Life Technologies, Carlsbad, CA), Roche GS-FLX 454 Genome Sequencer (Roche Applied Science, Germany), and the Helicos® Genetic Analysis Platform (Helicos Biosciences Corp., Cambridge, MA). Other developing technologies may be used. Reverse Transcriptase PCR (RT-PCR) [0078] The starting material is typically total RNA isolated from a human tumor, usually from a primary tumor. Optionally, normal tissues from the same patient can be used as an internal control. RNA can be extracted from a tissue sample, e.g., from a sample that is fresh, frozen (e.g. fresh frozen), or fixed and paraffin-embedded (e.g. formalin-fixed). [0079] General methods for RNA extraction are well known in the art and are disclosed in standard textbooks of molecular biology, including Ausubel et al., Current Protocols of Molecular Biology, John Wiley and Sons (1997). Methods for RNA extraction from paraffin embedded tissues are disclosed, for example, in Rupp and Locker, Lab Invest. 56:A67 (1987), and De Andres et al., BioTechniques 18:42044 (1995). In particular, RNA isolation can be performed using a purification kit, buffer set and protease from commercial manufacturers, such as Qiagen, according to the manufacturer's instructions. For example, total RNA from cells in culture can be isolated using Qiagen RNeasy mini-columns. Other commercially available RNA isolation kits include MasterPure™ Complete DNA and RNA Purification Kit (EPICENTRE®, Madison, WI), and Paraffin Block RNA Isolation Kit (Ambion, Inc.). Total RNA from fresh frozen tissue samples can be isolated using RNA Stat- 60 (Tel-Test). RNA prepared from a tumor sample can be isolated, for example, by cesium chloride density gradient centrifugation. The isolated RNA may then be depleted of ribosomal RNA as described in U.S. Pub. No. 2011/0111409. [0080] The sample containing the RNA is then subjected to reverse transcription to produce cDNA from the RNA template, followed by exponential amplification in a PCR reaction. The two most commonly used reverse transcriptases are avian myeloblastosis virus reverse transcriptase (AMV-RT) and Moloney murine leukemia virus reverse transcriptase (MMLV-RT). The reverse transcription step is typically primed using specific primers, random hexamers, or oligo-dT primers, depending on the circumstances and the goal of the assay. For example, extracted RNA can be reverse-transcribed using a GeneAmp RNA PCR kit (Perkin Elmer, CA, USA), following the manufacturer's instructions. The derived cDNA can then be used as a template in the subsequent PCR reaction. [0081] PCR-based methods use a thermostable DNA-dependent DNA polymerase, such as a Taq DNA polymerase. For example, TaqMan® PCR typically utilizes the 5'-nuclease activity of Taq or Tth polymerase to hydrolyze a hybridization probe bound to its target amplicon, but any enzyme with equivalent 5' nuclease activity can be used. Two oligonucleotide primers are used to generate an amplicon typical of a PCR reaction product. A third oligonucleotide, or probe, can be designed to facilitate detection of a nucleotide sequence of the amplicon located between the hybridization sites of the two PCR primers. The probe can be detectably labeled, e.g., with a reporter dye, and can further be provided with both a fluorescent dye, and a quencher fluorescent dye, as in a TaqMan® probe configuration. Where a TaqMan® probe is used, during the amplification reaction, the Taq DNA polymerase enzyme cleaves the probe in a template-dependent manner. The resultant probe fragments disassociate in solution, and signal from the released reporter dye is free from the quenching effect of the second fluorophore. One molecule of reporter dye is liberated for each new molecule synthesized, and detection of the unquenched reporter dye provides the basis for quantitative interpretation of the data. [0082] TaqMan® RT-PCR can be performed using commercially available equipment, such as, for example, ABI PRISM 7900™ Sequence Detection System™ (Perkin- Elmer-Applied Biosystems, Foster City, CA, USA), or Lightcycler (Roche Molecular Biochemicals, Mannheim, Germany). In a preferred embodiment, the 5' nuclease procedure is run on a real-time quantitative PCR device such as the ABI PRISM 7900™ Sequence Detection System™. The system consists of a thermocycler, laser, charge-coupled device (CCD), camera and computer. The system amplifies samples in a 384-well format on a thermocycler. The RT-PCR may be performed in triplicate wells with an equivalent of 2ng RNA input per 10 L-reaction volume. During amplification, laser-induced fluorescent signal is collected in real-time through fiber optics cables for all wells, and detected at the CCD. The system includes software for running the instrument and for analyzing the data. [0083] 5'-Nuclease assay data are generally initially expressed as a threshold cycle

("Ct")- Fluorescence values are recorded during every cycle and represent the amount of product amplified to that point in the amplification reaction. The threshold cycle (Ct) is generally described as the point when the fluorescent signal is first recorded as statistically significant. [0084] To minimize errors and the effect of sample-to-sample variation, RT-PCR is usually performed using an internal standard. The ideal internal standard gene (also referred to as a reference gene) is expressed at a constant level among cancerous and non cancerous tissue of the same origin (i.e., a level that is not significantly different among normal and cancerous tissues), and is not significantly affected by the experimental treatment (i.e., does not exhibit a significant difference in expression level in the relevant tissue as a result of exposure to chemotherapy). RNAs most frequently used to normalize patterns of gene expression are mRNAs for the housekeeping genes glyceraldehyde-3-phosphate- dehydrogenase (GAPDH) and β-actin. Gene expression measurements can be normalized relative to the mean of one or more (e.g., 2, 3, 4, 5, or more) reference genes. Reference- normalized expression measurements can range from 0 to 15, where a one unit increase generally reflects a 2-fold increase in RNA quantity. [0085] Real time PCR is compatible both with quantitative competitive PCR, where an internal competitor for each target sequence is used for normalization, and with quantitative comparative PCR using a normalization gene contained within the sample, or a housekeeping gene for RT-PCR. For further details see, e.g. Held et al, Genome Research 6:986-994 (1996). Desi2n of PCR Primers and Probes [0086] PCR primers and probes can be designed based upon exon, intron, or intergenic sequences present in the RNA transcript of interest. Primer/probe design can be performed using publicly available software, such as the DNA BLAT software developed by Kent, W.J., Genome Res. 12(4):656-64 (2002), or by the BLAST software including its variations. [0087] Where necessary or desired, repetitive sequences of the target sequence can be masked to mitigate non-specific signals. Exemplary tools to accomplish this include the Repeat Masker program available on-line through the Baylor College of Medicine, which screens DNA sequences against a library of repetitive elements and returns a query sequence in which the repetitive elements are masked. The masked sequences can then be used to design primer and probe sequences using any commercially or otherwise publicly available primer/probe design packages, such as Primer Express (Applied Biosystems); MGB assay- by-design (Applied Biosystems); Primer3 (Steve Rozen and Helen J. Skaletsky (2000) Primer3 on the WWW for general users and for biologist programmers. In: Rrawetz S, Misener S (eds) Bioinformatics Methods and Protocols: Methods in Molecular Biology. Humana Press, Totowa, NJ, pp 365-386). [0088] Other factors that can influence PCR primer design include primer length, melting temperature (Tm), and G/C content, specificity, complementary primer sequences, and 3 '-end sequence. In general, optimal PCR primers are generally 17-30 bases in length, and contain about 20-80%, such as, for example, about 50-60% G+C bases, and exhibit Tm's between 50 and 80 °C, e.g. about 50 to 70 °C. [0089] For further guidelines for PCR primer and probe design see, e.g. Dieffenbach, CW. et al, "General Concepts for PCR Primer Design" in: PCR Primer, A

Laboratory Manual, Cold Spring Harbor Laboratory Press, . New York, 1995, pp. 133-155; Innis and Gelfand, "Optimization of PCRs" in: PCR Protocols, A Guide to Methods and Applications, CRC Press, London, 1994, pp. 5-11; and Plasterer, T.N. Primerselect: Primer and probe design. Methods Mol. Biol. 70:520-527 (1997), the entire disclosures of which are hereby expressly incorporated by reference. MassARRAY® System [0090] In MassARRAY-based methods, such as the exemplary method developed by Sequenom, Inc. (San Diego, CA) following the isolation of RNA and reverse transcription, the obtained cDNA is spiked with a synthetic DNA molecule (competitor), which matches the targeted cDNA region in all positions, except a single base, and serves as an internal standard. The cDNA/competitor mixture is PCR amplified and is subjected to a post-PCR shrimp alkaline phosphatase (SAP) enzyme treatment, which results in the dephosphorylation of the remaining nucleotides. After inactivation of the alkaline phosphatase, the PCR products from the competitor and cDNA are subjected to primer extension, which generates distinct mass signals for the competitor- and cDNA-derived PCR products. After purification, these products are dispensed on a chip array, which is pre loaded with components needed for analysis with matrix- assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis. The cDNA present in the reaction is then quantified by analyzing the ratios of the peak areas in the mass spectrum generated. For further details see, e.g. Ding and Cantor, Proc. Natl. Acad. Sci. USA 100:3059-3064 (2003). Other PCR-based Methods [0091] Further PCR-based techniques that can find use in the methods disclosed herein include, for example, BeadArray® technology (Illumina, San Diego, CA; Oliphant et al., Discovery of Markers for Disease (Supplement to Biotechniques), June 2002; Ferguson et al., Analytical Chemistry 72:5618 (2000)); BeadsArray for Detection of Gene Expression® (BADGE), using the commercially available LuminexlOO LabMAP® system and multiple color-coded microspheres (Luminex Corp., Austin, TX) in a rapid assay for gene expression (Yang et al., Genome Res. 11:1888-1898 (2001)); and high coverage expression profiling (HiCEP) analysis (Fukumura et al., Nucl. Acids. Res. 31(16) e94 (2003). Microarrays [0092] In this method, polynucleotide sequences of interest (including cDNAs and oligonucleotides) are arrayed on a substrate. The arrayed sequences are then contacted under conditions suitable for specific hybridization with detectably labeled cDNA generated from RNA of a sample. The source of RNA typically is total RNA isolated from a tumor sample, and optionally from normal tissue of the same patient as an internal control or cell lines. RNA can be extracted, for example, from frozen or archived paraffin-embedded and fixed (e.g. formalin-fixed) tissue samples. [0093] For example, PCR amplified inserts of cDNA clones of a gene to be assayed are applied to a substrate in a dense array. Usually at least 10,000 nucleotide sequences are applied to the substrate. For example, the microarrayed genes, immobilized on the microchip at 10,000 elements each, are suitable for hybridization under stringent conditions. Fluorescently labeled cDNA probes may be generated through incorporation of fluorescent nucleotides by reverse transcription of RNA extracted from tissues of interest. Labeled cDNA probes applied to the chip hybridize with specificity to each spot of DNA on the array. After washing under stringent conditions to remove non-specifically bound probes, the chip is scanned by confocal laser microscopy or by another detection method, such as a CCD camera. Quantitation of hybridization of each arrayed element allows for assessment of corresponding mRNA abundance. [0094] With dual color fluorescence, separately labeled cDNA probes generated from two sources of RNA are hybridized pair wise to the array. The relative abundance of the transcripts from the two sources corresponding to each specified gene is thus determined simultaneously. The miniaturized scale of the hybridization affords a convenient and rapid evaluation of the expression pattern for large numbers of genes. Such methods have been shown to have the sensitivity required to detect rare transcripts, which are expressed at a few copies per cell, and to reproducibly detect at least approximately two-fold differences in the expression levels (Schena et at, Proc. Natl. Acad. Sci. USA 93(2): 106-149 (1996)). Microarray analysis can be performed on commercially available equipment, following the manufacturer's protocols, such as by using the Affymetrix GenChip® technology, or Incyte's microarray technology. Isolating RNA from Body Fluids [0095] Methods of isolating RNA for expression analysis from blood, plasma and serum {see for example, Tsui NB et al. (2002) Clin. Chem. 48,1647-53 and references cited therein) and from urine {see for example, Boom R et al. (1990) J Clin Microbiol. 28, 495-503 and reference cited therein) have been described. Immunohistochemistry [0096] Immunohistochemistry methods are also suitable for detecting the presence of gene fusions and alternative spliced junctions and applied to the method disclosed herein. Antibodies (e.g., monoclonal antibodies) that specifically bind a gene product of a gene of interest can be used in such methods. The antibodies can be detected by direct labeling of the antibodies themselves, for example, with radioactive labels, fluorescent labels, hapten labels such as biotin, or an enzyme such as horse radish peroxidase or alkaline phosphatase. Alternatively, unlabeled primary antibody can be used in conjunction with a labeled secondary antibody specific for the primary antibody. Immunohistochemistry protocols and kits are well known in the art and are commercially available. Proteomics [0097] The term "proteome" is defined as the totality of the proteins present in a sample (e.g. tissue, organism, or cell culture) at a certain point of time. Proteomics includes, among other things, study of the global changes of protein expression in a sample (also referred to as "expression proteomics"). Proteomics typically includes the following steps: (1) separation of individual proteins in a sample by 2-D gel electrophoresis (2-D PAGE); (2) identification of the individual proteins recovered from the gel, e.g. my mass spectrometry or N- terminal sequencing, and (3) analysis of the data using bioinformatics.

GENERAL DESCRIPTION OF THE RNA ISOLATION AND PREPARATIONFROM FIXED,

PARAFFIN-EMBEDDED SAMPLES FOR WHOLE TRANSCRIPTOME SEQUENCING

[0098] The steps of a representative protocol for profiling gene expression levels using fixed, paraffin-embedded tissues as the RNA source are provided in various published journal articles. (See, e.g., T.E. Godfrey et al,. . Molec. Diagnostics 2 : 84-91 (2000); K. Specht et al., Am. J. Pathol. 158: 419-29 (2001), M. Cronin, et al., Am J Pathol 164:35-42 (2004)). Modified methods can used for whole transcriptome sequencing as described in the Examples section. Briefly, a representative process starts with cutting a tissue sample section (e.g. about 10 µιη thick sections of a paraffin-embedded tumor tissue sample). The RNA is then extracted, and ribosomal RNA may be deleted as described in U.S. Pub. No. 201 1/01 11409. cDNA sequencing libraries may be prepared that are directional and allowed for single or paired-end sequencing using commercially available kits such as the ScriptSeq™ mRNA-Seq Library Preparation Kit (Illumina). The libraries may also be barcoded for multiplex sequencing using commercially available barcode primers such as the RNA-Seq Barcode Primers from Illumina. PCR is then carried out to generate the second strand of cDNA to incorporate the barcodes and to amplify the libraries. After the libraries are quantified, the sequencing libraries may be sequenced as described herein.

KITS OF THE INVENTION [0099] The materials for use in the methods of the present invention are suited for preparation of kits produced in accordance with well known procedures. The present invention thus provides kits comprising agents, which may include primers and/or probes, for quantitating the level of the disclosed gene fusions or alternative spliced junctions or their expression products via methods such as whole transcriptome sequencing or RT-PCR for predicting prognostic outcome. Such kits may optionally contain reagents for the extraction of RNA from tumor samples, in particular, fixed paraffin-embedded tissue samples and/or reagents for whole transcriptome sequencing. In addition, the kits may optionally comprise the reagent(s) with an identifying description or label or instructions relating to their use in the methods of the present invention. The kits may comprise containers (including microliter plates suitable for use in an automated implementation of the method), each with one or more of the various reagents (typically in concentrated form) utilized in the methods, including, for example, pre-fabricated microarrays, buffers, the appropriate nucleotide triphosphates (e.g., dATP, dCTP, dGTP and dTTP; or rATP, rCTP, rGTP and UTP), reverse transcriptase, DNA polymerase, RNA polymerase, and one or more probes and primers of the present invention (e.g., appropriate length poly(T) or random primers linked to a promoter reactive with the RNA polymerase). Mathematical algorithms used to estimate or quantify prognostic information are also potential components of kits.

REPORTS [00100] The methods of this invention are suited for the preparation of reports summarizing the findings of the methods of the present invention. A "report" as described herein, is an electronic or tangible document that includes elements that provide information of interest relating the presence of gene fusions in a sample, the presence of alternative spliced junctions in a sample, or a likelihood assessment and its results. A subject report can be completely or partially electronically generated, e.g., presented on an electronic display

(e.g., computer monitor). A report can further include one or more of: 1) information regarding the testing facility; 2) service provider information; 3) patient data; 4) sample data; 5) an interpretive report, which can include various information including: a) indication; b) test data, where test data can include information regarding the presence of a gene fusion or alternative spliced junction of interest, and 6) other features. [00101] The present invention therefore provides methods of creating reports and the reports resulting therefrom. The report may include a summary of the gene fusions or alternative spliced junctions, in the cells obtained from the patient's tumor sample. The report may include a prediction that the patient has an increased likelihood of breast cancer recurrence or the report may include a prediction that the subject has a decreased likelihood of breast cancer recurrence. The report may include a recommendation for a treatment modality such as surgery alone or surgery in combination with chemotherapy. The report may be presented in electronic format or on paper. [00102] Thus, in some embodiments, the methods of the present invention further include generating a report that includes information regarding the patient' s likelihood of long-term survival without breast cancer recurrence. For example, the methods of the present invention can further include a step of generating or outputting a report providing the results of a patient response likelihood assessment, which can be provided in the form of an electronic medium (e.g., an electronic display on a computer monitor), or in the form of a tangible medium (e.g., a report printed on paper or other tangible medium). [00103] A report that includes information regarding the likelihood that a patient will exhibit breast cancer recurrence is provided to a user. An assessment as to the likelihood that a cancer patient will exhibit breast cancer recurrence is referred to as a "likelihood assessment." A person or entity who prepares a report ("report generator") may also perform the likelihood assessment. The report generator may also perform one or more of sample gathering, sample processing, and data generation, e.g., the report generator may also perform one or more of: a) sample gathering; b) sample processing; and c) determining the presence of a gene fusion or an alternative spliced junction. Alternatively, an entity other than the report generator can perform one or more sample gathering, sample processing, and data generation. [00104] The term "user" or "client" refers to a person or entity to whom a report is transmitted, and may be the same person or entity who does one or more of the following: a) collects a sample; b) processes a sample; c) provides a sample or a processed sample; and d) generates data for use in the likelihood assessment. In some cases, the person or entity who provides sample collection and/or sample processing and/or data generation, and the person who receives the results and/or report may be different persons, but are both referred to as "users" or "clients." In certain embodiments, e.g., where the methods are completely executed on a single computer, the user or client provides for data input and review of data output. A "user" can be a health professional (e.g., a clinician, a laboratory technician, a physician (e.g., an oncologist, surgeon, pathologist), etc.). [00105] In embodiments where the user only executes a portion of the method, the individual who, after computerized data processing according to the methods of the invention, reviews data output (e.g., results prior to release to provide a complete report, a complete, or reviews an "incomplete" report and provides for manual intervention and completion of an interpretive report) is referred to herein as a "reviewer." The reviewer may be located at a location remote to the user (e.g., at a service provided separate from a healthcare facility where a user may be located). [00106] Where government regulations or other restrictions apply (e.g., requirements by health, malpractice, or liability insurance), all results, whether generated wholly or partially electronically, are subjected to a quality control routine prior to release to the user.

COMPUTER -BASED SYSTEMS AND METHODS [00107] The methods and systems described herein can be implemented in numerous ways. In one embodiment of the invention, the methods involve use of a communications infrastructure, for example, the internet. Several embodiments of the invention are discussed below. The present invention may also be implemented in various forms of hardware, software, firmware, processors, or a combination thereof. The methods and systems described herein can be implemented as a combination of hardware and software. The software can be implemented as an application program tangibly embodied on a program storage device, or different portions of the software implemented in the user's computing environment (e.g., as an applet) and on the reviewer's computing environment, where the reviewer may be located at a remote site (e.g., at a service provider's facility). [00108] In an embodiment of the invention, during or after data input by the user, portions of the data processing can be performed in the user-side computing environment. For example, the user-side computing environment can be programmed to provide for defined test codes to denote a likelihood "score," where the score is transmitted as processed or partially processed responses to the reviewer's computing environment in the form of test code for subsequent execution of one or more algorithms to provide a result and/or generate a report in the reviewer's computing environment. The score can be a numerical score (representative of a numerical value) or a non-numerical score representative of a numerical value or range of numerical values (e.g., "A": representative of a 90-95% likelihood of a positive response; "High": representative of a greater than 50% chance of a positive response (or some other selected threshold of likelihood); "Low": representative of a less than 50% chance of a positive response (or some other selected threshold of likelihood), and the like. [00109] As a computer system, the system generally includes a processor unit. The processor unit operates to receive information, which can include test data (e.g., the presence of a gene fusion or an alternative spliced junction) and may also include other data such as patient data. This information received can be stored at least temporarily in a database, and data analyzed to generate a report as described above. [00110] Part or all of the input and output data can also be sent electronically. Certain output data (e.g., reports) can be sent electronically or telephonically (e.g., by facsimile, using devices such as fax back). Exemplary output receiving devices can include a display element, a printer, a facsimile device and the like. Electronic forms of transmission and/or display can include email, interactive television, and the like. In an embodiment of the invention, all or a portion of the input data and/or output data (e.g., usually at least the final report) are maintained on a web server for access, preferably confidential access, with typical browsers. The data may be accessed or sent to health professionals as desired. The input and output data, including all or a portion of the final report, can be used to populate a patient' s medical record that may exist in a confidential database as the healthcare facility. [00111] The present invention also contemplates a computer-readable storage medium (e.g., CD-ROM, memory key, flash memory card, diskette, etc.) having stored thereon a program which, when executed in a computing environment, provides for implementation of algorithms to carry out all or a portion of the results of a likelihood assessment as described herein. Where the computer-readable medium contains a complete program for carrying out the methods described herein, the program includes program instructions for collecting, analyzing and generating output, and generally includes computer readable code devices for interacting with a user as described herein, processing that data in conjunction with analytical information, and generating unique printed or electronic media for that user. [00112] Where the storage medium includes a program that provides for implementation of a portion of the methods described herein (e.g., the user-side aspect of the methods (e.g., data input, report receipt capabilities, etc.)), the program provides for transmission of data input by the user (e.g., via the internet, via an intranet, etc.) to a computing environment at a remote site. Processing or completion of processing of the data is carried out at the remote site to generate a report. After review of the report, and completion of any needed manual intervention, to provide a complete report, the complete report is then transmitted back to the user as an electronic document or printed document (e.g., fax or mailed paper report). The storage medium containing a program according to the invention can be packaged with instructions (e.g., for program installation, use, etc.) recorded on a suitable substrate or a web address where such instructions may be obtained. The computer-readable storage medium can also be provided in combination with one or more reagents for carrying out a likelihood assessment (e.g., primers, probes, arrays, or such other kit components). [00113] Having described the invention, the same will be more readily understood through reference to the following Examples, which are provided by way of illustration, and are not intended to limit the invention in any way. All citations through the disclosure are hereby expressly incorporated by reference. EXAMPLE 1

Materials and Methods - Providence Cohort [00114] Patients [00115] One hundred and thirty-six primary breast cancer FFPE tumor specimens with clinical outcomes were provided by Providence St. Joseph Medical Center (Burbank, CA), with institutional review board approval. The time to first recurrence of breast cancer or death due to breast cancer (including death due to unknown cause) was determined from these records. Patients who were still alive without breast cancer recurrence or who died due to known other causes were considered censored at the time of last follow-up or death. These tumor specimens were used for biomarker discovery in the development of the Oncotype DX® assay. See e.g., U.S. Patent No. 7,081,340; S. Paik et al., The New England Journal of Medicine 351, 2817 (2004). For the present study, 136 specimens had adequate RNA remaining. Among the 136 patients, 26 experienced breast cancer recurrence or death due to breast cancer. Clinical characteristics of the patients in the Providence cohort are described in Sinicropi et al., PLoS ONE 7(7):e40092 (2012) which is incorporated by reference in its entirety. [00116] RNA-Seq Sample Preparation and Sequencing [00117] Transcriptome RNA-Seq analysis of the Providence cohort is described in Sinicropi et al., PLoS ONE 7(7):e40092 (2012). Total RNA was prepared from three 10-µιη- thick sections of FFPE tumor tissue as previously described using the MasterPure™ Purification Kit (Epicentre® Biotechnologies, Madison, WI). M. Cronin et al, The American Journal of Pathology 164, 35 (Jan, 2004). One hundred nanograms of the isolated RNA were depleted of ribosomal RNA as described. See U.S. Pub. No. 2011/0111409. Sequencing libraries for whole transcriptome analysis were prepared using ScriptSeq™ mRNA-Seq Library Preparation Kits (Epicentre ® Biotechnologies, Madison, WI). During the cDNA synthesis step, additional incubation for 90 minutes at 37°C was implemented in the reverse transcription step to increase library yield. After 3'-terminal tagging, the di-tagged cDNA was purified using MinElute ® PCR Purification Kits (Qiagen, Valencia, CA). Two 6 base index sequences were used to prepare barcoded libraries for duplex sequencing (RNA-Seq Barcode Primers; Epicentre® Biotechnologies, Madison, WI). PCR was carried out through 16 cycles to generate the second strand of cDNA, incorporate barcodes, and amplify libraries. The amplified libraries were size-selected by a solid phase reversible immobilization, paramagnetic bead-based process (Agencourt® AMPure® XP System; Beckman Coulter Genomics, Danvers, MA). Libraries were quantified by PicoGreen® assay (Life Technologies, Carlsbad, CA) and visualized with an Agilent Bioanalyzer using a DNA 1000 kit (Agilent Technologies, Waldbronn, Germany).

[00118] Two RNA-Seq libraries with different index barcodes were loaded into each lane of flow cells. The cluster generation in flow cells was carried out in an Illumina cBOT™ instrument using TruSeq™ SR Cluster Kits v2 following the manufacturer's protocol (Illumina Inc.; San Diego, CA). The flow cells were subsequently transferred to an Illumina HiSeq®2000 instrument (Illumina, Inc.) for sequence analysis using TruSeq SBS Kit v3-HS (50 cycles) following the manufacturer's protocol. The single-read runs were carried out for a total of 57 cycles including 7 cycles for the index sequences and 50 cycles (i.e. 50 bases) for the insert sequences.

[00119] Data Quality Assessment

[00120] Each sequencing lane was duplexed with two patient sample libraries using a 6 base barcode to differentiate between them. The mean read ratio +/-SD between the two samples in each lane was 1.05+0.38 and the mean +/-SD percentage of un-discerned barcodes was 2.08%+1.63%. Using principal components analysis and other exploratory data analysis methods, no systematic differences were found among samples associated with flow cell or barcode.

[00121] In a run-in phase of the study, duplicate libraries were prepared for 8 samples selected at random from the study set of 136. RefSeq RNA coverage for these libraries ranged between 3.1M and 6.7M uniquely mapped reads. Log count Pearson correlations among duplicate libraries ranged between 0.947 and 0.985. Single libraries were prepared for the remaining 128 samples and distributed in duplex mode among the lanes of 8 flow-cells. Sequencing in 3 lanes failed. Two libraries had low yield, resulting in low coverage. Three lanes were flagged by various Illumina process monitoring indices: low Q30 (coverage = 2.8M and 4.2M), high cluster density (coverage = 1.6M and 1.8M), or inadequate imaging (coverage = 3.3M and 3.1M). For the remaining lanes, sample coverage ranged between 2.5M and 7.3M reads. New libraries for the samples that had low yield were prepared and sequenced. Libraries in the failed and flagged lanes, as well as some of the low coverage samples, were re-sequenced. Replicate correlations among all sequenced samples were very high, 0.985 for the samples with the high cluster density in the original run, and over 0.990 for all others. For the analysis data set, data for one of each of the duplicate libraries from the run-in experiment were kept. For the samples for which new libraries were prepared and for the samples in the failed and flagged lanes, the reads from the subsequent run were used. For the samples with low coverage for which the library was reprocessed, reads from the two runs were pooled. For the rest of the samples, the reads from the single lane were used. Results differed little when other data analysis procedures were used, for example, using only the second run when libraries were reprocessed. EXAMPLE 2 Rush Cohort [00122] 78 patient samples as described in Cobleigh et al., Clin. Cancer Res. 11:8623-8631 (2005) and in U.S. Patent No. 7,569,345 were obtained from women with invasive breast cancer and > 10 positive nodes with no evidence of metastatic disease who had surgery at Rush University Medical Center from 1979 to 1999. Clinical outcome data were available for all patients. Patients who were still alive without breast cancer recurrence or who died due to known other causes were considered censored at the time of last follow-up or death. For the present study, 76 specimens had adequate RNA remaining for RNA-Seq. EXAMPLE 3 Bioinformatics Approach to Identifying Gene Fusions

[00123] An overview of the bioinformatics approach used to identify gene fusions in samples from the Providence and Rush cohorts is depicted in Figure 1A. The pipeline was developed in LINUX SHELL, PERL or R languages, and the data processing was on LINUX clusters. Data from the Providence and Rush cohorts was assessed separately in Steps 1-3, which are described herein. In Step 4, data from the Providence and Rush were merged together. However the expression profiling step was carried out separately within each cohort considering inter-cohort differences in block archive ages and library quality (Figure IB). [00124] The underlying gene fusion method is based on the detection of distant splicing within a single read feature of a RNA-seq aligner GSNAP (Wu,T.D. and Nacu,S. (2010) Fast and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics, 26, 873-881). The utility of GSNAP for gene fusion detection has been demonstrated in gene fusion detection methods such as GSTRUCT-fusions and GFP (Seshagiri,S. et al. (2012) Recurrent R-spondin fusions in colon cancer. Nature, 488, 660- 664; Ju,Y.S. et al. (2012) A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. , 22, 436-445). Both methods depend on GSNAP to provide fusion read candidates, and apply a set of filtering modules to remove false positives in paired-end RNA-seq datasets. In RNA- seq paired end libraries prepared from fresh frozen tissue, bridging reads mapped to each side of fusion junction sites provide a very powerful filter in both GSTRUCT and GFP approaches, therefore single end read datasets are disadvantaged. To compensate for the short FFPE RNA length with median library size around 100 bp in Providence, we leverage data from the two patient cohorts as shown in Figure 1A. The sample based strategy analyzes each RNA-seq sample individually and nominates candidate fusion junctions for the following cohort based strategy, which confirms the presence of each of fusion candidates in each individual sample across the whole cohort by examining read alignment and expression profiling evidence. To increase the possibilities of identifying recurrent gene fusions across the two cohorts studied here, fusion candidate templates provided by the sample based strategy from both Providence and Rush were merged together in the beginning step of the cohort based strategy (Figure IB). However the expression profiling step was carried out separately within each cohort considering inter-cohort differences in block archive ages and library quality (Figure IB). The insert size and complexity of the Providence cohort libraries is higher than that of the Rush cohort libraries, so here we describe results from the Providence RNA-seq dataset (Sinicropi,D. et al. (2012) Whole Transcriptome RNA-Seq Analysis of Breast Cancer Recurrence Risk Using Formalin-Fixed Paraffin-Embedded Tumor Tissue. PLoS ONE, 7, e40092) to illustrate the performance of the cohort based computational approach.

[00125] Step 1: Mapping FASTQ Files to the Human Genome Using GSNAP [00126] Raw sequencing data from the Providence and Rush cohorts were converted to FASTQ files using CASAVA software. The FASTQ files were mapped to the human genome (version GHCh37/hgl9) along with RefSeq splicing sites using the RNA-Seq aligner GSNAP. An important feature of GSNAP is its ability to detect a distant spliced junction within a single read. Local spliced junctions derive from splicing events within a single gene in a consistent transcription direction, whereas distant sliced junctions derive from splicing events between different genes or chromosomes. Distant splicing events can also include splicing events occurring within the same gene, but in the opposite transcription direction. Distant splicing events, therefore, include translocations, inversions, and the like.

[00127] Two filters were installed to remove low quality and unwanted reads. Good quality reads were identified as reads in which at least 30% of the bases have Sanger quality score 20 or above. Reads failing this threshold were flagged as low-quality and removed from alignment (BAM) files. Simultaneously, a number of abundant sequences including biological sequences (e.g., ribosomal RNA and mitochondrial sequences), and sequences introduced during library prep (e.g., phiX), were considered undesirable for gene fusion detection and were removed from alignment (BAM) files. Only reads passing both filtering thresholds and uniquely mapped to human genome were retained for the further analyses. Such reads were considered distant spliced reads.

[00128] The uniquely mapped reads in the cleaned BAM files were converted to (non-normalized) gene feature counts that provide expression values for exonic, intronic, and intergenic regions. The gene feature count is the number of aligned bases from reads mapped within the feature region. The gene level expression values were calculated by aggregating counts for exonic or intronic features. These gene feature counts are referred to as "gene tables" in Figure 1.

[00129] Step 2 : Retesting Reads Using GSNAP

[00130] In order to remove false positives, reads that mapped to the human genome in Step 1 were retested using GSNAP parameters that favor local alignment. Each alignment from the GSNAP rerun was examined, and any reads meeting all following criteria were considered as having false positive distant splicing reads in the original GSNAP output, and thus removed for the further analyses: (1) the total matched length was 44bp or more; (2) the insertion length was 1bp or 0; and (3) the deletion length was lbp or 0. For the Providence cohort, Step 2 filtered out 18% of the distant spliced junctions. Reads that successfully passed through this step were considered to include a distant spliced junction. [00131] Step 3: Extracting Gene Fusions [00132] In Step 3, the resulting distant splicing junctions were then annotated and candidate gene fusions were selected. Specifically, the alignments of reads that passed GSNAP re-testing step were examined, and reads with any mismatches within 5bp of the distant splicing junction site or mapped to the anti-sense strand of annotated genes were removed from further analyses. The remaining reads were grouped according to the distant splicing junction sites, and each junction site was annotated based on UCSC refseq sequence annotation. Junctions mapped to a pseudogene or multiple mapped refseq genes were removed. At this stage, candidate gene fusions met one of the following criteria: (1) they mapped to different chromosomes; (2) they mapped to different refseq genes; (3) they were in opposite directions on same chromosome; or (4) they were at least 1MB apart if on the same chromosome. For the Providence cohort, Step 3 filtered out 20% of the distant spliced junctions. Steps 1-3 make up the sample based approach identified in Figure 1. [00133] Step 4 : Building Templates [00134] A five template set was created to remove false positives introduced by homologous template sequences and to enable accurate mapping of supporting reads. At this stage, information from both the Providence and Rush cohorts was combined. The features of the five template set are depicted in Figure 2. The five template set included the following individual templates, each of which included 100 bp:

1. Fusion template: The 50 bp exonic sequence of the preserved region of donor gene plus 50 bp exonic sequence of the preserved region of acceptor gene, 2. Donor template: The 50 bp exonic sequence of the preserved region of donor gene plus 50 bp exonic sequence of the discarded region of donor gene, 3. Acceptor template: The 50 bp exonic sequence of the discarded region of acceptor gene plus 50 bp exonic sequence of the preserved region of acceptor gene, 4. Donor genomic template: The 50 bp upstream genomic sequence of donor splicing site plus 50 bp downstream genomic sequence of donor splicing site, and 5. Acceptor genomic template: The 50 bp upstream genomic sequence of acceptor splicing site plus 50 bp downstream genomic sequence of acceptor splicing site.

[00135] Donor and acceptor exon only or genomic containing template sequences were used as controls. The sequence of each template in the 5 template set was retrieved and annotated for each candidate gene fusion. Candidate gene fusions were considered to be false positives and were removed if any of its templates had the identical sequence, but were mapped to different locations on the human genome.

[00136] BLAST was used to investigate the homology of the remaining candidate gene fusions. A second five template set for each of the remaining candidate gene fusions was created. This template included the following individual templates, each of which included 300 bp:

a. Fusion template: The 150 bp exonic sequence of the preserved region of donor gene plus 150 bp exonic sequence of the preserved region of acceptor gene, b. Donor template: The 150 bp exonic sequence of the preserved region of donor gene plus 150 bp exonic sequence of the discarded region of donor gene, c. Acceptor template: The 150 bp exonic sequence of the discarded region of acceptor gene plus 150 bp exonic sequence of the preserved region of acceptor gene, d. Donor genomic template: The 150 bp upstream genomic sequence of donor splicing site plus 150 bp downstream genomic sequence of donor splicing site, and e. Acceptor genomic template: The 150 bp upstream genomic sequence of acceptor splicing site plus 150 bp downstream genomic sequence of acceptor splicing site.

[00137] Homology between (b) the donor template and (c) the acceptor template and between (d) the donor genomic template and (e) the acceptor genomic template was evaluated. The fusion template (a) was used to provide sequence information for RT-PCR experiments. Any candidate gene fusion meeting the following criteria was removed from further analysis: (1) sequence identity of more than 14bp of 300bp of the donor template and acceptor template; (2) sequence identity of more than 14bp of 300bp of the donor genomic template and acceptor genomic template; and (3) less than 50bp exonic sequence on either side of fusion, donor, or acceptor template sequences. This step removed 27% of the candidate gene fusions from the Providence cohort.

[00138] Step 5 : Retrieving Reads

[00139] The templates from the remaining candidate gene fusions from both the Providence and the Rush cohorts were used to create a genomic index using a tool from the GSNAP package. Based on the genomic location of all candidate fusion template sets, all short reads mapped near any junction sites and reads not mapped in the original GSNAP BAM file per RNA-seq library were selected. The selected reads were re-mapped into the built template genomic index by GSNAP with the splicing detection parameter turn off. The alignments between supporting reads and fusion templates were screened to allow minimum of 5bp exact match sequence as overhang across the junction site. [00140] Only reads uniquely mapped to the fusion template were kept. Reads were examined according to the below parameters to determine if they mapped to the fusion template with good quality: (1) no mismatch around 5bp of junctions of any template; (2)number of reads with indels is no more than 75% of all reads mapped to a given template; (3) reads with splicing evidence in the original BAM files were not allowed to be mapped to fusion template; (4) no splicing or distant splicing allowed on these lOObp template sequences; (5) no soft clipping of more than 3bp on each read side; (6) no deletion more than lbp at a given indel location; and (7) no insertion more than lbp at a given indel location. Step 5 filtered out 5% of the candidate gene fusions from the Providence cohort. [00141] Figure 3 shows output reads for the gene fusions listed in Tables A and B. Because there were several gene fusion junctions having the same sequence, Figure 3 shows information regarding 105 gene fusion junctions while Tables A and B list 100 gene fusion candidates. [00142] Step 6 : Expression Profiling [00143] Expression profiles provide additional evidence for gene fusions. The utilization of expression data for gene fusion detection is a feature of the COPA (Cancer Outlier Profiling Analysis) method that was devised for analysis of microarray databases (Tomlins et al., 2005). Cancer related genes identified as expression outliers in microarray experiments led to the discovery of TMPRSS2 to ETS transcription factors, the first known recurrent gene fusions in common solid carcinomas. Gene fusion RNAs are expected to exhibit a marked expression discontinuity between the preserved side and discarded side of a given fusion junction, compared to samples without that gene fusion. Recently published gene fusions detected using RNA-seq have displayed this discrete expression pattern at acceptor fusion junction sites under RNA-seq platform (Lipson, D. et al. (2012) Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nature Medicine, 18, 382-384; Ju,Y.S. et al. (2012) A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res., 22, 436-445). Multiple bioinformatics approaches including FusionSeq (Sboner,A. et al. (2010) FusionSeq: a modular framework for finding gene fusions by analyzing paired-end RNA-sequencing data. Genome Biol, 11, R104), deFuse (McPherson,A. etal. (2011) deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data. PLoS Comput Biol, 7) and TopHat-Fusion (Kim,D. and Salzberg,S.L. (2011) TopHat-Fusion: an algorithm for discovery of novel fusion transcripts. Genome Biol, 12, R72) have used expression data in their pipelines. However all these methods are based on an analysis of subjects, one by one. The cohort-based approach described here compares expression levels across the cohort of subjects to find expression outliers as well as exon/intron level expression interruption corresponding to matching fusion junctions. Due to the large proportion of sequences that map to introns in FFPE RNA-seq data (Sinicropi, D. et al. (2012) Whole Transcriptome RNA-Seq Analysis of Breast Cancer Recurrence Risk Using Formalin-Fixed Paraffin- Embedded Tumor Tissue. PLoS ONE, 7, e40092), introns were used along with exons to enhance expression measurements. The expression profiling step can nominate candidate fusions despite the existence of very limited reads. In fact, here we used the expression profile data to predict known fusions in samples having no detected fusion sequences [00144] Methods for expression profiling included the following: The gene table described in Step 1 was normalized by scaling factors as described by R package DEseq, which is available at http://bioconductor.org/packages/release/bioc/html/DESeq.html). Anders and Huber, Genome Biology 11:R106 (2010). The intron immediately before the splicing site on the acceptor gene and the intron immediately after the splicing site on the donor gene were identified and excluded from expression analyses. The remaining exons and introns were analyzed and classified as either discarded or preserved based on their expression level. Discarded exons and introns having counts below 250 were padded to 250. Such counts were equivalent to 5 reads prior to normalization. The gene feature (exon or exon/intron) counts were normalized by the sequence length. The expression interrupt ratios of normalized counts between preserved and discarded sides were calculated for donor and accep le according to the following formula:

[00145] As an exemplary case, the fusion RABEP1->DNAH9 (a tier 1 fusion) was initially found in a single Providence sample and was supported by two non-redundant reads across the fusion template (Figure 3.7). There are multiple reads across the donor RABEP1 mRNA template junction and no reads across the acceptor DNAH9 mRNA template junction. The same trend exists in pre-mRNA templates, therefore it suggests the strong donor promoter drives the expression of fusion transcripts which appear as one of two expression outliers in the Providence cohort. When the exon/intron expression levels of acceptor DNAH9 were examined across Providence, the other expression outlier appears to have the same discrete expression pattern which exists in the sample but no other samples. The individual exon/intron expression levels of DNAH9 also agree with the observation from the heatmap (data not shown). Therefore we predicted the sample has a tier 3 fusion RABEP1- >DNAH9 although there are no reads across fusion junction in that sample. Both fusion events were validated by TaqMan with an average CT of 30. 11 and 34.86 respectively (Table 1). This prediction succeeded due to the fact that the fusion transcript is the prevalent form over the non-fused acceptor transcript (Figure 3.7).

[00146] Expression profiling results for the candidate gene fusions are shown in Figure 4. Figure 4 shows a scatter plot of normalized gene level counts for the indicated donor and acceptor genes. Figure 4 also shows bar plots of normalized counts of each exon and intron of acceptor gene of the identified samples in the order of their genomic location. The vertical line separates the acceptor gene into discarded and preserved sides. Because there were several gene fusion junctions having the same sequence, Figure 4 shows information regarding 105 gene fusion junctions.

[00147] Step 7 : Review Evidence

[00148] Data were manually reviewed to identify candidate gene fusions. The following rules were used to select the final candidate gene fusions: (1) multiple samples sharing the same hits, but without good expression evidence were removed; (2) fusions with a minimum of two non-duplicate reads and a minimum of 15bp overhang were kept; and (3) expression profiling evidence was reviewed to select candidates with favorable expression evidence. Steps 4-7 make up the cohort based approached identified in Figure 1.

[00149] Gene Fusion List

[00150] Overall, 108 fusion events consisting of 100 unique fusion junctions were identified in the two cohorts (Tables A and B). Table A provides information regarding the cohort, the fusion junction, the fusion genes, COSMIC gene, donor Entrez gene ID, donor gene type, donor HUGO gene symbol, donor gene description, acceptor Entrez gene ID, acceptor gene type, acceptor HUGO gene symbol, and acceptor gene description. The symbol "->" indicates the splicing direction of the gene fusion. The symbol "_" is used interchangeably with the symbol "->" to denote junctions in the figures and tables. Splice donors are located to the left of the arrow and splice acceptors are located to the right of the arrow. The "+" symbol denoted in the junctions, refers to the plus-strand of the chromosome, whereas the "-" symbol denotes the minus-strand of the chromosome. Table B provides the gene fusion and the nucleotide sequence of the 100 unique gene fusions. [00151] The majority of gene fusions are intra-chromosomal genomic rearrangements (69 out of total 100 fusion junctions), and this is consistent with findings of others (Robinson, D.R. et al. (2011) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature Medicine, 17, 1646-1651; Edgren,

H. et al. (201 1) Identification of fusion genes in breast cancer by paired-end RNA- sequencing. Genome Biol, 12, R6. Of the 100 unique fusions, only TFG->GPR128 has been discovered previously (Mitelman,F. et al. (2012) Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer; Asmann,Y.W. etal. (2012) Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer. Cancer Res, 72, 1921-1928). It is noteworthy that some of these rare fusions are detected in both of the examined patient cohorts. Here, we validated 3 recurrent gene fusions including TFG->GPR128, ESR1->AKAP12 and RABEP 1->DNAH9 by TaqMan assay using amplified RNA from 6, 3 and 2 patients respectively in the two cohorts of 212 total patients. Interestingly, among three ESR1->AKAP12 fusion events in three different patients, there are two unique fusion junctions sharing the same acceptor junction site but differing at the donor junction sites by one exon. Since both ESR1->AKAP12 fusion junctions are in frame and the differed ESR1 exon doesn't harbor any known functional domains, these two fusion transcripts can be assumed possessing the same biological function. Further protein domain analysis showed both fusion proteins replace ESR1 ligand binding site with functional domains of AKAP12 (Figure 9). Interestingly, the lost ligand binding site interacts with another AKAP family member AKAP13. (Rubino, D. et al. (1998) Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene, 16, 2513- 2526). Both fusion protein isoforms could potentially cause constitutive ligand-independent signaling, therefore disregulate protein kinase A pathway (Figure 9). On the other hands, we also identified some different junctions between two identical fused partners within a single patient. One Providence patient has three different ERBB2->IKZF3 junctions, which only differ at the donor junction site, and one Rush patient has two different TRIM37->BCAS3 junctions which only differ at the donor junction site (see Table 3, below). [00152] Also, multiple recurrent partners fused to different partners were found within the two cohorts. In the Providence sample harboring ESR1->AKAP12, another fusion ESRl->C6orf211was found and validated, it suggests multiple copies of ESR1 existed and they were fused to different acceptors. LRP5 was also found and validated to be fused to different acceptors KAT6A and SLC22A24 in the same patient. However ADK was found and validated to be an acceptor in the fusion DLG5->ADK in one patient, and a donor in the fusion ADK->C10orfll in another patient. Similarly, the gene ACACA was also found and validated as the donor of ACACA->MSI2 in one patient, and the acceptor of UTP18- >ACACA in another patient. We further searched the Mitelman fusion database with all 184 unique fusion partners including donors and acceptors from the final 108 fusion list, and 29 partners were found fused to various different partners in the database (Mitelman, F. et al. (2012) Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer). Among them, ACACA, BCAS3, DDX5, FBXL20, IKZF3, RAF1, TFG and TRPS1 were fused to more than one partner in the database. These observations suggest fusion events are unlikely random although they appear to be rare in solid tumors. [00153] The identified fusion partners also tend to be cancer related, and 82% of the total 83 gene fusions identified from the Providence cohort have at least one partner belonging to COSMIC database which contains many frequently altered cancer specific genes. This is consistent with other evidence for frequently mutated genes prone to genomic rearrangements in the cancer genomes (Ju,Y.S. et al. (2012) A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res., 22, 436-445). The discovery of gene fusions containing partners that regulate repair of DNA double-strand breaks and homologous recombination such as RAD21, RDM1, BRCA2 and SHFM1 is consistent with abundant evidence for DNA replication infidelity in cancer.

EXAMPLE 4 Validation of the Candidate Gene Fusions

[00154] 60 of the 100 fusion junctions were selected based on cancer relevance of fused partner genes, and tested by quantitative RT-PCR assay (TaqMan®) using amplified RNA samples from selected patients harboring corresponding candidate fusions. Reverse transcription was carried out using the OmniscriptTM RT Kit (Qiagen) by incubating amplified RNA with random hexamers and gene-specific primers at 37°C for 1 hour. Primer, probe, and amplicon sequences are shown in Supplementary Table 2. Fluorogenic probes were dual-labeled with 5'-FAM as a reporter and 3'-BHQ-2 as a quencher. Primers and probes were designed using the Primer3 program restricting amplicon sizes to 65-85 bps (http://frodo.wi.mit.edu/). When Primer3 failed, primer and probe sequences were optimized manually to ensure optimal performance of the TaqMan® assay design for the chimeric transcripts. Reverse transcription reaction in the absence of RNA template (i.e., water) was always used as a negative control in all assays. The samples that were previously validated as positive or negative for a particular gene fusion junction were served as controls when needed. Since the RT reaction was multiplexed by using a pooled gene specific primer set, the cDNA derived from a RNA sample was tested with all fusion gene qPCR assays within a validation gene set. All RNA samples were assayed in triplicate qPCR reactions with lOul per well. Thermalcycling conditions were standard for all assays (A heat activation step of 95°C for 10 minutes followed by 40 cycles of 95°C for 20 seconds and 60°C for 45 seconds). Table C indicates the fusion genes, the fusion junction, primer design method, amplicon length, and primer, probe, and amplicon sequences. [00155] At the end of this process, 83 fusion junctions representing only 0.56% of candidate fusion junctions from Step 1 were selected in the Providence dataset. Overall, 108 fusion events consisting of 100 unique fusion junctions were identified in the two cohorts (Tables A and B). Candidate fusions were classified into 3 tiers based on the levels of supporting evidence (Figure IB). A total of 60 fusion junctions were selected based on cancer relevance of fused partner genes, and tested by quantitative RT-PCR assay using amplified RNA samples from selected patients harboring corresponding candidate fusions. Tier 1 fusions have the strongest sequence evidence and highest validation rate. The second tier was selected based on the combination of sequence and expression profiling. The third tier has the least evidence since they are purely predicted from gene expression patterns, thus with the lowest validation rate (Figure IB). [00156] An important feature of the gene fusion detection pipeline described here is using expression profiling to select tier 2 and tier 3 candidate gene fusions with minimal sequencing data at fusion junctions. Generally, functionally important gene fusions in cancer are characterized by donor genes that are expressed at relatively high levels in non-fused state, by acceptor genes that are expressed at relatively low levels in non-fused state. The strong promoter of a donor gene may up-regulate expression of an oncogenic acceptor gene to contribute to the disease pathology (Mitelman, F. et al. (2007) The impact of translocations and gene fusions on cancer causation. Nature Reviews Cancer, 7, 233-245). Among 3 1 validated tier 1 fusions, only 7 (23%) fail to show an interrupted expression patterns at either donor or acceptor fusion junctions. Therefore, the filtered false negative gene fusions by expression profiling are probably low and also less likely to be less pathologically relevant. As an internal control, we performed TaqMan assays on 4 fusion candidates that had single non-duplicate reads but without interrupted expression patterns, and only one, and only ESRl->C6orf211, was validated. These two assessments suggest the false negative rate of our pipeline at Step 6 at around 25%. It has been observed fused genes tend to have high copy number variation (Supper, J. et al. (2012) Detecting and visualizing gene fusions. Methods; Kangaspeska,S. et al. (2012) Reanalysis of RNA-Sequencing Data Reveals Several Additional Fusion Genes with Multiple Isoforms. PLoS ONE, 7, e48745). Multiple normal copies of candidates with a single copy of a fused gene can mask the expression profiling of the fused genes, which can lead to the false negative fusions undetected by expression profiling approach. [00157] Fusion transcripts may result from genomic rearrangements or transcript level rearrangements such as trans-splicing which is also biologically relevant. Another type of trans-splicing is known reverse transcriptase artifacts derived from sequence homology (Houseley, J. and Tollervey, D. (2010) Apparent Non-Canonical Trans-Splicing Is Generated by Reverse Transcriptase In Vitro. PLoS ONE, 5, e12271). Although our method cannot distinguish genomic rearrangement derived gene fusions from trans-splicing derived, we used homology sequence search between templates to remove false positive fusions potentially caused by homologous sequences introduced by mapping algorithm or RT errors. This strategy should sufficiently reduce these errors. The existence of vast amount of true negative gene fusions validated by TaqMan (Table 1) also supports the very limited RT based trans- splicing artifact in this study. [00158] Although the gene fusion event is relatively low per patient, which could be attributed to the low quality of FFPE RNA-seq libraries, patient stratification across a breast cancer cohort based on fusion frequencies demonstrates the clinical prognostic power of fusion detection. This was further validated in the biological pathway and network analysis as fusion signature genes were highlighted in the known cancer related network (Figure 5C). However, we observed some relapsed patients with low fusion signature index in both cohorts (Figure 5D). It is probably due to the lack of genes from another fundamental underlying cancer mechanism which is inflammation in this fusion signature. Therefore the high genome instability level is a sufficient but not necessary condition for tumor progression, which is consistent with complexities of hallmarks of cancer (Hanahan, D. and

Weinberg, R.A. (201 1) Hallmarks of Cancer: The Next Generation. Cell, 144, 646-674). [00159] Table 1 shows a summary of the results from the RT-PCR experiments of the 108 fusion events. Shown is the average CT from triplicate lOul TaqMan assays.

TABLE 1 +chrll:68133170->-chrll:62863578 LRP5->SLC22A24 31.77 +chrl0:133761295->-chrl0:91344222 PPP2R2D->PANK1 34.57 +chr 15:99442850->+chr 18:50278424 IGF1R->DCC 33.36 -chr20: 16553874->+chr20: 17240885 KIF16B->PCSK2 34.6 +chr2:223725976->+chr2:223553063 ACSL3->M0GAT1 NA +chrl7:37866134->-chrl7:37949186 ERBB2->IKZF3 NA +chrl7:37868300->-chrl7:37949186 ERBB2->IKZF3 NA -chrl7:78120592->-chr21:45953806 EIF4A3->TSPEAR 35.02 +chrl2: 122473333->-chr 12: 103872225 BCL7A->C12orf42 37.82 +chr6:7 1123405->+chr6: 123038932 FAM135A->PKIB 37.87 -chrl4:103523336->-chr4: 152594048 CDC42BPB->PET112 40 -chrl4:51131897->-chrl4:51245522 SAV1->NIN NA -chr 12: 15370363->+chr 19:547280 RERG->GZMM 40 -chrl9:35989618->-chrl9:35617921 DMKN->LGI4 NA -chr21 :27326904->+chr21 :30547033 APP->C21orf7 NA +chr2:11680234->-chr2:9098771 GREB 1->MBOAT2 40 -chr12:116450602->-chr 12:39764063 MED13L->KIF21A NA -chrl5:68695257->+chrl7:80417868 ITGA11->NARF NA -chrX: 122799493->+chrX: 117676688 THOC2->DOCKll NA +chrl0:31608221->+chr8:96166259 ZEB 1->PLEKHF2 NA -chrl9:55610152->-chrl 1:1769349 PPP1R12C->IFITM10 40 -chrl5:49059257->+chrl5:90976951 CEP152->IQGAP1 NA -chr1:169454801->-chr3 :113442942 SLC19A2->NAA50 NA +chr5: 174905642->+chr5: 110782384 SFXN1->CAMK4 40 +chr2:208435045->-chr2:98543950 CREB1->TMEM131 40 +chr6 :152129499->+chr6 :151785588 ESRl->C6orf211 36.19 +chr8: 117779030->-chr8: 117879000 UTP23->RAD21 40 -chrl6:87760371->-chr4:3526778 KLHDC4->LRPAP1 NA +chr7 :7 84 1374->+chr7 :8043538 LOC729852->GLCCIl NA +chrl5:80750317->-chrl5:81274523 ARNT2->MESDC2 40 +chr8 :18067689->+chr8 :38099768 NAT1->DDHD2 NA +chr9:129623018->-chr9: 127818286 ZBTB34->SCAI 40 -chrX:76907604->-chrX:83419395 ATRX->RPS6KA6 40 -chr9: 103 115054->-chrl 1:85742653 TEX10->PICALM 40 +chr3:14960340->-chr4:75673359 FGD5->BTC NA -chr3:42744071->-chrl7:73328878 HHATL->GRB2 40 -chr6: 117923167->+chr6: 126359851 G0PC->TRMT11 NA -chr9: 14693227->-chrl3:31037831 ZDHHC21->HMGB1 NA +chr9:95821 112->-chr8:9551 1734 SUSD3->KIAA1429 NA +chr7 :56032394->-chr7 :82595803 GBAS->PCLO 40 +chr6:158244478->+chr8:61531139 SNX9->RAB2A 40 -chrlO: 101769595->+chrl0: 123954555 DNMBP->TACC2 40 +chr6:7 108001->+chr6:755595 1 RREB1->DSP 40 +chrl :111833572->+chr7:64291 829 CHIA->ZNF138 NA -chrl9:37956215->-chr7:96324203 ZNF569->SHFM1 NA -chrl7:57092971->+chrl7:58786580 TRIM37->BCAS3 34.66 +chr22:22020420->+chr22 :30064322 PPIL2->NF2 NA -chrl:53746259->-chrl:54275419 LRP8->TMEM48 40 +chrl7:48797192->-chrl7:36047395 LUC7L3->HNF1B 32.13 -chr8: 117878825->+chr8: 124968232 RAD2 1->FER 1L6 34.78 +chr3 :100438902->+chr3 :100348442 TFG->GPR128 31.03 +chrl7:33968994->-chr7:961 15729 AP2B1->FLJ42280 NA +chr3 :100438902->+chr3:100348442 TFG->GPR128 32.83 +chr4:71670133->+chr4:71337932 RUFY3->MUC7 NA +chr3 :100438902->+chr3:100348442 TFG->GPR128 34.68 +chr3 :100438902->+chr3:100348442 TFG->GPR128 35.36 +chrl7:73521906->-chr3: 131442469 LLGL2->CPNE4 NA -chr2:97527316->+chr2:28561317 SEMA4C->BRE 31.08 +chr6:15220 1906->+chr6 :151669846 ESR1->AKAP12 31.78 -chrl7:58577760->+chrl7:72345323 APPBP2->KIF19 NA +chr8:38883403->-chr8:41585524 ADAM9->ANK1 NA -chrl7:27492960->-chrl7:28120955 MY018A->SSH2 NA +chr7:30113748->-chr9:80537261 PLEKHA8->GNAQ NA -chrl7:37453380->+chrl7:44751780 FBXL20->NSF 31.16 -chrl7:57094657->+chrl7:58786580 TRIM37->BCAS3 NA -chr20:6242 1174->+chr20 :62559688 ZBTB46->DNAJC5 NA +chr6:15220 1906->+chr6 :151669846 ESR1->AKAP12 36.09 EXAMPLE 5 Identification of Recurrent Gene Fusions

[00160] Heatmaps and bar plots generated in Example 3 (Step 6: Expression Profiling) were analyzed to identify gene fusions present in multiple patients from the Providence and Rush cohorts. Results are shown in Table 2, which lists the gene fusion, number of Providence patient samples positive for the gene fusion via heatmap inspection and the number of reads spanning the gene fusion junction (split reads) per Providence patient sample, number of Rush patient samples positive for the gene fusion via heatmap inspection and the number of reads spanning the gene fusion junction (split reads) per Rush sample. The symbol "†" indicates that multiple junctions were observed for the ESR1- >AKAP12 gene fusion. The asterisks "*" in Table 2 indicate that the identified fusion was predicted to be recurrent because split reads were not identified in all patient samples that were positive for the gene fusion via expression profiling evaluation. For example, the data for the TFG->GPR12 gene fusion indicates that 2 patients positive for the gene fusion via heatmap inspection in Providence cohort, 1 patient in the Providence cohort that was positive for that gene fusion via expression profiling evaluation had 3 supporting split reads, and 1 patient has 0 split read. However, in the Rush cohort, of the 4 patients positive for the gene fusion via heatmap inspection, 2 patient samples had 3 split reads, 1 patient sample had 1 split read, and 1 patient sample had 0 split reads. The symbol "*" indicates that TFG_GPR128 TFG->GPR128 has been discovered previously Mitelman, F. et al. (2012) Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer; Asmann, Y.W. et al. (2012) Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific

Therapeutic Targets in Breast Cancer. Cancer Res, 72, 1921-1928. The symbol " —" in various samples from the Rush cohort indicates that there were no samples positive for the indicated gene fusion and there were no split reads supporting the gene fusion. Accordingly, for those gene fusions, recurrence was observed among the Providence patient samples only. TABLE 2 TFG_GPR128** 2 samples total 4 samples total 1 sample: 3 split reads 2 samples: 3 split reads (positive via RT-PCR) (positive via RT-PCR) 1 sample: 0 split reads 1 sample: 1 split read (positive by RT-PCR) (positive via RT-PCR) 1 sample: 0 split reads (positive via RT-PCR)

RABEP1_DNAH9* 2 samples total 1 sample: 2 reads (positive via RT-PCR) 1 sample: 0 reads (positive via RT-PCR) EIF2C3_ZP2* 3 samples total 1 sample: 4 split reads (positive via RT-PCR) 2 samples: 0 split reads (negative via RT-PCT)

NFYA_TDRG1 * 10 samples total 1 sample: 2 split reads (negative via RT-PCT) 9 samples: 0 split reads (negative via RT-PCT) KIF16B_PCSK2* 3 samples total 1 sample: 1 split read (positive via RT-PCT) 2 samples: 0 split reads (negative via RT-PCT) BCL7A_C12orf42 3 samples total 1 sample: 1 split read (positive via RT-PCT) 2 samples: 0 split reads (negative via RT-PCT) RERG_GZMM* 4 samples total 1 sample: 1 split read (negative via RT-PCT) 3 samples: 0 split reads (negative via RT-PCT) RAF1_NKIRASI* 3 samples total 1 sample: 6 split reads (positive via RT-PCR) 2 samples: 0 split reads (negative via RT-PCT)

UTP23_RAD21* 4 samples total 1 sample: 2 split reads (negative via RT-PCT) 3 samples 0 split reads (negative via RT-PCT) LRP5_SLC22A24* 2 samples total 1 sample: 2 split reads (RT-PCR results unavailable) 1 sample: 0 split reads (RT-PCR results unavailable)

LRP5_KAT6A* 3 samples total 1 sample: 26 split reads (positive via RT-PCT) 2 samples: 0 split reads (negative via RT-PCT)

PREX1_SLC9A8* 2 samples total 1 sample: 22 split reads (RT-PCR results unavailable) 1 sample: 0 split reads (RT-PCR results unavailable)

PPP2R1A_NLRP8* 2 samples total 1 sample: 2 split reads (positive via RT-PCR) 1 sample: 0 split reads (negative via RT-PCR)

PQLC1_LINC00330 2 samples total each sample: 1 split read (RT-PCR results unavailable)

[00161] The list of candidate gene fusions was also analyzed to identify recurrent gene fusions within a given sample in order to identify genes that may be hotspots for chromosomal aberrations that cause gene fusions. Table 3 shows gene fusions that were recurrent in a single sample. TABLE 3 ESR1_AKAP12 ESR1_AKAP12: 4 1 split reads ESRl_C6orf21 1 ESRl_C6orf21 1: 4 split reads

[00162] The list of candidate gene fusions was further analyzed to identify recurrent gene fusions present in different samples (either within a single or cohort or between cohorts) in order to identify genes that may be hotspots for chromosomal aberrations that cause gene fusions. Results are shown in Table 4. TABLE 4

[00163] Also, multiple recurrent partners fused to different partners were found within the two cohorts. In the Providence sample harboring ESR1->AKAP12, another fusion ESRl->C6orf211was found and validated, it suggests multiple copies of ESR1 existed and they were fused to different acceptors. LRP5 was also found and validated to be fused to different acceptors KAT6A and SLC22A24 in the same patient. However ADK was found and validated to be an acceptor in the fusion DLG5->ADK in one patient, and a donor in the fusion ADK->C10orfll in another patient. Similarly, the gene ACACA was also found and validated as the donor of ACACA->MSI2 in one patient, and the acceptor of UTP18- >ACACA in another patient. We further searched the Mitelman fusion database with all 184 unique fusion partners including donors and acceptors from the final 108 fusion list, and 29 partners were found fused to various different partners in the database (Mitelman, F. et al. (2012) Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer). Among them, ACACA, BCAS3, DDX5, FBXL20, IKZF3, RAF1, TFG and TRPS1 were fused to more than one partner in the database. These observations suggest fusion events are unlikely random although they appear to be rare in solid tumors. EXAMPLE 7 Identifying Alternative Spliced Junctions

[00164] An overview of the method for identifying alternative spliced junctions is shown in Figure 1. To identify alternative spliced junctions, Steps 1-3 of Example 3 were performed using the Providence cohort samples. Novel distant splice junctions from the candidate gene fusions resulting from Step 3 of Example 3 were annotated using the Ensembl Reference (Biomart). First, Ensemble was used to create a canonical splice junction dictionary to enable identification of novel distant spliced junctions. 98% of the distant spliced junctions were considered novel. Next, the type of alternative spliced junction was classified as involving a novel donor (0.3%), a novel acceptor (0.42%), a novel donor and acceptor (1.27%), exon shuffling (96.37%), exon skipping (0.92%), or an unknown case (0.71%). 74.7% of the distant spliced junctions remained after application of a same gene filter and 19.6% of the distant spliced junctions remained after application of a minimum non-duplicate read filter. Finally, clinical information regarding breast cancer recurrence in the Providence cohort was applied to identify alternative spliced junctions that correlated with cancer recurrence. 1.8% of the junctions passed Fisher's Test of a p-value less than 0.05. [00165] Six candidate alternative splicing junctions were identified using the above method. The candidate alternative splicing junctions are shown in Table 5. Table 5 shows the gene symbol, the alternative spliced junction within the gene, Fisher' s p value, the non recurrent ratio, the recurrent ratio, the non-recurrence sample count, the recurrence sample count, and the splice type identified by the method described herein. Alternative spliced junctions in UBXN7, SOX5, KIAA0368, PIKC3C, and DAP3 correlated with non-recurrence of breast cancer whereas an alternative spliced junction MITDl correlated with recurrence of breast cancer. Furthermore, investigation of the alternative spliced junction in PIKC3 predicts a fusion protein with a junction at amino acids 701 and 887 (data not shown). TABLE 5

EXAMPLE 8 Validating Alternative Splice Junctions

[00166] Validation of the alternative splice junctions is determined using quantitative RT-PCR. Quantitative RT-PCR analysis using TaqMan® RT PCR is used to investigate the six alternative spliced junctions identified in Example 7. Reverse transcription is carried out using the OmniPure RT kit (Qiagen). Reverse transcription is performed by combining random hexamers and gene-specific primers at 37°C for 1 hour. [00167] Fluorogenic probes are dual-labeled with 5'-FAM as a reporter and 3'- BHQ-2 as a quencher. Primers and probes are designed using the Primer3 program (http://frodo.wi.mit.edu/). In some cases, primer and probe sequences are optimized manually to ensure optimal performance of the TaqMan® assay design for FFPE samples. The TaqMan® assay designs are manually optimized to select an amplicon size less than 100 bases in length and to enable the probe to approximately span the alternative spliced junction. No template (i.e., water) is used as a negative control. [00168] Results from quantitative RT-PCR are obtained and analyzed to investigate the validity of the alternative spliced junctions identified using the bioinformatics approach. EXAMPLE 9 Increased Fusion Events Are Associated with Poor Tumor Prognosis

[00169] The average fusion events per patient across Providence and Rush cohorts are 0.63 and 0.29 respectively, far less than the average of 4.2 fusions in fresh frozen breast cancer biopsies (Robinson, D.R. et al. (201 1) Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature Medicine, 17, 1646-1651; Asmann, Y.W. et al. (2012) Detection of Redundant Fusion Transcripts as Biomarkers or Disease-Specific Therapeutic Targets in Breast Cancer. Cancer Res, 72, 1921-1928). This difference can reasonably be attributed to the poor quality of FFPE RNAs. This is born out in the Rush and Providence data sets, the former having older archival ages therefore poorer quality RNA and yielding a far fewer identified gene fusions (Figure 5A). [00170] Within each patient cohort we investigated whether the number of fusion events detected within individual tumors related to the likelihood of disease recurrence. We thus stratified patients according to the numbers of fusion events within each cohort (Figure 5A). Since not all fusions have tested by TaqMan assay, the final fusion list (Tables A and B) was used in stratification regardless of validation results. In view of the limited number of fusions detected in the Rush dataset we evaluated just 2 categories: fusion detected or not detected, whereas in the Providence dataset we evaluated four abundance categories. The 8 patients with greater than two fusions (subsequently referred to as multiple fusions) in Providence have statistically significant increased recurrence risk compared to patients from three other groups (Figure 5B). In the Rush dataset disease recurred at an increased rate among patients with detected fusions, although this relationship doesn't not quite achieve statistical significance cutoff. To check whether minimizing the block age effect improves this relationship, we resorted to subset patients into either upper three or lower three quantiles of the block age since sizable patients with comparable block age were difficult to obtain considering the small cohort size. The separations of patients with fusions from patients without fusions were significantly improved in both subsets of Rush (Figure 6). The similar results were observed with Providence block age subsets. Interestingly, we also observed enrichment of estrogen receptor negative (ER-) patients in Providence multiple fusion group and Rush fusion group (Figure 3A), consistent with the well-known poor prognosis of ER- patients (DeSombre and Jensen, 1980) and the published evidence of increased chromosome instability levels in ER- tumors (Endesfelder et al., 201 1). [00171] In order to assess the biological significance of the fusion frequency, we identified genes differentially expressed between the multiple fusion group versus no fusion group in the Providence cohort. Since ER status can effect gene expression greatly, an additive model of edgeR using ER status as background was applied to remove ER effect in identifying genes related to fusion frequency. We took extra cautions to examine the pair- wise comparisons between any Providence fusion frequency groups, and confirmed the differentially expressed genes between multiple fusion samples versus no fusion samples are specific to this comparison, which achieved maximum differentially expression among all comparisons tested (Table 6). Accordingly, Table 6 shows pairwise differentially expressed (DE) gene analysis between sample categories by fusion number in Providence show differentially expressed fusion gene signatures are specific to the comparison of multiple fusion samples to no fusion samples. TABLE 6

Note: The additive model of edgeR was used with ER status as background with FDR<0.05 for each pairwise DE analysis. The up-regulated and down-regulated gene numbers are shown. The numbers in parenthesis are the overlapping genes with DE genes of multiple fusion samples versus no fusion samples.

[00172] Both multiple fusion samples and no fusion samples were also segregated according to ER status, and the overlapped genes between each category were compared (Figure 7). Although ER+ samples contribute more to the differentially expressed genes between multiple fusion samples versus no fusion samples due to the majority of Providence samples are ER+ (Figure 7A), the overlapped fusion differentially expressed genes with genes differentially expressed solely due to ER status are reasonably small (Figure 7B). These investigations showed evidence that the 134 differentially expressed genes obtained by the edgeR additive model reflect the difference by fusion frequency rather than by ER status. Then the total 134 genes were uploaded to Reactome FI (functional interaction) database via Cytoscape Plugin (G. Wu et al., 2010) to perform network clustering. As shown in Figure 5C, 84 up-regulated genes in multiple fusion group versus no fusion group formed a network, which we termed as the fusion gene signature (Table 7). We show that expression of the fusion gene signature in Providence tumors was also significantly greater in patients with multiple fusions than in patients with 1 or 2 detected fusions (Figure 5D). Further, in the Rush cohort the expression of this signature is significantly greater in tumors with identified fusions (Figure 5D). [00173] These fusion signature genes were clustered into five related functional steps (Figure 5C). Strikingly, these functions are all cancer epithelial cells related, and are the characteristics of prominent pathological hallmarks of cancers (Hanahan, D. and Weinberg, R.A. (2011) Hallmarks of Cancer: The Next Generation. Cell, 144, 646-674). The underlying mechanism of these cancer hallmarks is the cancer enabling characteristic, genome instability, which can lead to chromosome rearrangement and therefore gene fusions. Thus the relationship between gene fusion frequency reflecting genome stability level and tumor prognosis is supported by the current understanding of tumor progression. TABLE 7 hydroxyprostaglandin HPGD 3248 dehydrogenase 15-(NAD) 0 Mitogenic signaling insulin-like growth factor 1 IGF1R 3480 receptor 0 Mitogenic signaling mitogen-activated protein kinase MAPK6 5597 6 0 Mitogenic signaling serine/threonine protein kinase MST4 51765 MST4 0 Mitogenic signaling PEX13 5194 peroxisomal biogenesis factor 13 0 Mitogenic signaling phosphatidylinositol-5-phosphate PIP4K2C 79837 4-kinase, type II, gamma 0 Mitogenic signaling PRDX1 5052 peroxiredoxin 1 0 Mitogenic signaling protein tyrosine phosphatase, PTPRF 5792 receptor type, F 0 Mitogenic signaling TMOD2 29767 tropomodulin 2 (neuronal) 0 Mitogenic signaling TUBB3 10381 tubulin, beta 3 class III 0 Mitogenic signaling USP8 9101 ubiquitin specific peptidase 8 0 Mitogenic signaling ATP synthase, H+ transporting, mitochondrial Fl complex, beta ATP5B 506 polypeptide 1 Energy metabolism BRF2, subunit of RNA polymerase III transcription BRF2 55290 initiation factor, BRFl-like Energy metabolism cell division cycle 20 homolog CDC20 991 (S. cerevisiae) 1 Energy metabolism CDCA8 55143 cell division cycle associated 8 1 Energy metabolism cytochrome c oxidase subunit COX6B1 1340 Vlb polypeptide 1 (ubiquitous) 1 Energy metabolism glucose-6-phosphate G6PD 2539 dehydrogenase Energy metabolism isocitrate dehydrogenase 2 IDH2 3418 (NADP+), mitochondrial 1 Energy metabolism Leol, Pafl/RNA polymerase II complex component, homolog (S. LEOl 123169 cerevisiae) Energy metabolism methionine adenosyltransferase I, MAT1A 4143 alpha Energy metabolism MED 13 9969 mediator complex subunit 13 1 Energy metabolism PGK1 5230 phosphoglycerate kinase 1 1 Energy metabolism proteasome (prosome, PSMB2 5690 macropain) subunit, beta type, 2 Energy metabolism proteasome (prosome, macropain) 26S subunit, ATPase, PSMC4 5704 4 1 Energy metabolism SWI/SNF related, matrix associated, actin dependent SMARCD regulator of chromatin, subfamily 2 6603 d, member 2 1 Energy metabolism smg-8 homolog, nonsense mediated mRNA decay factor (C. SMG8 55181 elegans) 1 Energy metabolism SNRPB2 6629 small nuclear ribonucleoprotein 1 Energy metabolism polypeptide B TFCP2L1 29842 transcription factor CP2-like 1 1 Energy metabolism UBB 7314 ubiquitin B 1 Energy metabolism vacuolar protein sorting 4 VPS4B 9525 homolog B (S. cerevisiae) 1 Energy metabolism CFL1 1072 cofilin 1 (non-muscle) 2 Cell motility 3-hydroxy-3-methylglutaryl-CoA HMGCR 3156 reductase 2 Cell motility intracisternal A particle-promoted IPP 3652 polypeptide 2 Cell motility myosin VA (heavy chain 12, MY05A 4644 myoxin) 2 Cell motility MY05C 55930 myosin VC 2 Cell motility p21 protein (Cdc42/Rac)- PAK4 10298 activated kinase 4 2 Cell motility protein phosphatase 1, regulatory PPP1R1B 84152 (inhibitor) subunit IB 2 Cell motility RAB11FIP RAB 11 family interacting protein 1 80223 1 (class I) 2 Cell motility SEC23B 10483 Sec23 homolog B (S. cerevisiae) 2 Cell motility solute carrier family 6 (neurotransmitter transporter, SLC6A9 6536 glycine), member 9 2 Cell motility transmembrane emp24 domain TMED2 10959 trafficking protein 2 2 Cell motility transmembrane emp24 protein TMED9 54732 transport domain containing 9 2 Cell motility TMOD3 29766 tropomodulin 3 (ubiquitous) 2 Cell motility transient receptor potential cation TRPM7 54822 channel, subfamily M, member 7 2 Cell motility cAMP-regulated phosphoprotein, ARPP19 10776 19kDa 3 Cell cycle BRCA1 interacting protein C- BRIP1 83990 terminal helicase 1 3 Cell cycle eukaryotic translation initiation EIF3I 8668 factor 3, subunit I 3 Cell cycle GA binding protein transcription GABPB1 2553 factor, beta subunit 1 3 Cell cycle GINS complex subunit 2 (Psf2 GINS2 51659 homolog) 3 Cell cycle H2AFZ 3015 H2A histone family, member Z 3 Cell cycle karyopherin alpha 2 (RAG cohort KPNA2 3838 1, importin alpha 1) 3 Cell cycle methyl-CpG binding domain MBD2 8932 protein 2 3 Cell cycle OCLN 100506658 occludin 3 Cell cycle POLI 11201 polymerase (DNA directed) iota 3 Cell cycle glutaminyl-tRNA synthase QRSL1 55278 (glutamine-hydrolyzing)-like 1 3 Cell cycle RRM2 6241 ribonucleotide reductase M2 3 Cell cycle ATP6V0B 533 ATPase, H+ transporting, 4 DNA damage response lysosomal 21kDa, V0 subunit b DDB1 and CUL4 associated DCAF7 10238 factor 7 4 DNA damage response heat shock protein 90kDa beta HSP90B1 7184 (Grp94), member 1 4 DNA damage response LDHA 3939 lactate dehydrogenase A 4 DNA damage response LOXL4 84171 lysyl oxidase-like 4 4 DNA damage response Mdm2, p53 E3 ubiquitin protein MDM2 4193 ligase homolog (mouse) 4 DNA damage response NAD(P)H dehydrogenase, NQOl 1728 quinone 1 4 DNA damage response prolyl 4-hydroxylase, alpha P4HA1 5033 polypeptide I 4 DNA damage response protein disulfide isomerase PDIA6 10130 family A, member 6 4 DNA damage response solute carrier family 2 (facilitated SLC2A1 6513 glucose transporter), member 1 4 DNA damage response TK1 7083 thymidine kinase 1, soluble 4 DNA damage response aldo-keto reductase family 1, AKR1A1 10327 member Al (aldehyde reductase) 5 serine hydroxymethyltransferase SHMT2 6472 2 (mitochondrial) 5 B-cell receptor-associated protein BCAP31 10134 3 1 6 CANX 821 calnexin 6

Methods regarding RNA-seq expression analysis [00174] The differentially expressed genes were analyzed by edgeR (Robinson, M.D. et al. (2010) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics, 26, 139-140) based on base count tables tallied from GSNAP mapping results. For the comparison of Providence multiple fusions versus no fusion samples, the low expression filter requires minimum 8 samples with at least 250 base counts which equivalent to 5 reads, and the Cox-Reid profile-adjusted likelihood method was used to estimate mean-variance relationships. Due to the strong influence of ER status on gene expression profiling, the additive model of edgeR was used to get differentially expressed genes between multiple fusion samples versus no fusion samples adjusting for differences between ER positive and negative status. The false discovery rate of differentially expressed genes was set at 0.05 of Bonferroni-Holm method adjusted p values. [00175] The differentially expressed genes were mapped to a cancer focused protein-protein interaction database, Reactome FI database as instructed by the Reactome FIs Cytoscape plugin. The network was clustered by a built-in spectral partition based clustering algorithm, and nodes in different network modules (Figure 5C). Example 10

Alternative Methods of Expression Profiling to Identify Gene Fusions

[00176] In other experiments, based on the expression profiling, the acceptor exon boundary is identified precisely. A chimera database is built with that fixed on the right hand of the sequence; the left part of the sequence is one of the 300,000 exons from RefSeq (all 20,000+ genes). Mapping each read against the chimera database potentially identifies the donor exon/gene.

Example 11

Identification of ESR1-AKAP12 Fusion Using Outlier Expression

[00177] In a separate set of experiments, outlier expression analysis was used to identify an ESR1-AKAP12 fusion in a patient sample from the Rush cohort. In summary, the fusion between ESRl and AKAP12 in the Rush cohort was identified by a combination of identifying the expression outlier of AKAP12 from the entire cohort followed by the sequence comparison for AKAP12 and ESRl. [00178] First, expression analysis was used to identify the original read counts for the entire Rush cohort. The original read counts were normalized by Q3 then log2 transformed to assess the expression level for each gene. AKAP12 gene expression was plotted in a histogram to identify the expression outlier(s), defined by the 3 standard deviation of the mean level. Figure 8 shows the histogram of AKAP12 counts for the patients in the Rush cohort. The expression outlier is circled. [00179] Second, reads were investigated to identify those spanning the fusion between ESRl and AKAP12. All of the reads from the above patient were mapped against the human genome by Bowtie. The fusion reads were in the unmapped category. Using ESRl and AKAP12 as the two separate targets, the unmapped reads were aligned against them. The reads which could be aligned both to ESRl and AKAP12 were then identified. This process identified the following read maps to the junction between ESRl and AKAP12 at +chr6:152201906(ESR1)->+chr6:151669846(AKAP12). [00180] All references cited throughout the disclosure, including the examples, are hereby expressly incorporated by reference for their entire disclosure. [00181] While the present invention has been described with reference to what is considered to be specific embodiments, it is to be understood that the invention is not so limited. To the contrary, the invention is intended to cover various modifications and equivalents included within the spirit and scope of the appended claims. TABLE A 357) box helicase 5 breast cancer C-type anti- +chrl6: lectin estrogen 111548 domain resistan 79->- CLEC1 family ce 4 chrl6:l 6A- 16, (non Provide 191415 >BCAR CLEC1 protein- CLEC1 member miscRN protein nee 4 4 6A 23274 coding 6A A 400500 A BCAR4 coding) sema domain, immuno globulin domain (Ig), transme mbrane domain RNA (TM) binding and motif, chr2:97 short single 527316- cytoplas stranded >- SEMA4 mic interact! chr2:16 C- domain, Provide 113127 >RBMS SEMA4 protein- SEMA4 (semaph protein- protein nee 5 1 C 54910 coding C orin) 4C 5937 coding RBMS1 1 +chrl 1: 634492 ankyrin 50->- 1, Provide chr8:41 RT 3- protein- reticulo protein- erythroc nee 591587 >ANK1 RT 3 10313 coding RT 3 n 3 286 coding ANK1 ytic transme +chrl :1 mbrane 657971 and 69->- coiled- chrl:16 UCK2- uridine- coil Provide 569735 >TMCO protein- cytidine protein- domains nee 8 1 UCK2 7371 coding UCK2 kinase 2 54499 coding TMCOl 1

chrl7:3 553620 acetyl- musashi 1- CoA homolo >+chrl7 ACAC carboxy g 2 Provide :554787 A- ACAC protein- ACAC lase protein- (Drosop nee 40 >MSI2 A 3 1 coding A alpha 124540 coding MSI2 hila) +chrl0: chromo 759843 some 10 49- open >+chrl0 ADK- adenosi reading Provide :777957 >C10orf protein- ne protein- ClOorfl frame nee 66 11 132 coding ADK kinase 83938 coding 1 11 tetratric opeptide repeat, ankyrin +chrl7: repeat 610869 and 87->- coiled- chrl7:3 TANC2 coil Provide 424727 protein- containi protein- RAD52 nee 6 >RDM1 TANC2 261 15 coding TANC2 ng 2 201299 coding RDM1 motif 1 staufen, R A chr20:4 binding 779073 protein, 2- homolo >+chr20 g topoiso Provide :396900 STAU1- protein- (Drosop protein- merase nee 34 >TOPl STAU1 6780 coding STAU1 hila) 7150 coding TOPI (DNA) I Provide +chr8:4 VDAC3 VDAC3 7419 protein- VDAC3 voltage- 11141 protein- IL1RAP interleu nee 225638 coding depende coding L I kin 1 2- >IL1RA nt anion receptor >+chrX: PL1 channel accessor 293010 3 y 55 protein like 1 v-raf-1 murine leukemi NFKB chr3:12 a viral inhibito 705312- oncogen r RAF1- e interact! Provide chr3:23 >NKIR protein- homolo protein- NKIRA ng Ras- nee 942540 AS1 RAF1 5894 coding RAF1 s i 28512 coding S I like 1 +chrl0: chromos 127411 ClOorfl ome 10 unchara 703- 37- open cterized >+chrl0 >LOCl reading LOC10 LOC10 Provide :127266 001697 ClOorfl protein- ClOorfl frame 100169 miscRN 016975 016975 nee 780 52 37 26098 coding 37 137 752 A 2 2 UTP18 small subunit (SSU) process +chrl7: ome 493546 compon acetyl- 65->- ent CoA chrl7:3 UTP18- UTP18_ homolo carboxy Provide 548714 >ACAC ACAC protein- g protein- ACAC lase nee 4 A A 51096 coding UTP18 (yeast) 3 1 coding A alpha zona eukaryo pellucid +chrl:3 tic a 649289 translati glycopr 9->- on otein 2 chrl6:2 initiatio (sperm Provide 121287 EIF2C3 EIF2C3 protein- n factor protein- receptor nee 9 ->ZP2 ZP2 192669 coding EIF2C3 2C, 3 7783 coding ZP2 ) protein +chrl9: phospha NLR 527093 tase 2, family, 16- PPP2R1 regulato pyrin >+chrl9 A- ry domain Provide :564734 >NLRP PPP2R1 protein- PPP2R1 subunit protein- containi nee 33 8 A 5518 coding A A, alpha 126205 coding NLRP8 n 8 +chrl3: 103249 553- tripeptid breast >+chrl3 TPP2- yi cancer Provide :328905 >BRCA protein- peptidas protein- 2, early nee 59 2 TPP2 7174 coding TPP2 e ll 675 coding BRCA2 onset membra ne- associat ed ring finger +chrl:3 (C3HC4 265021 ) 6, E3 7- TXLNA ubiquiti >+chr5: n Provide 104337 >MAR protein- taxilin protein- MARC protein nee 06 CH6 TXLNA 200081 coding TXLNA alpha 10299 coding H6 ligase regulati +chr8:l 047095 synaptic 24->- membra chr8:10 ne dihydro Provide 543661 REVIS2- protein- exocyto protein- pyrimid nee 7 >DPYS REVIS2 9699 coding REVIS2 sis 2 1807 coding DPYS inase B3GAL beta- transloc chrl:23 NT2- 1,3-N- ase of Provide 562895 >TOM B3GAL protein- B3GAL acetylga protein- TOMM outer nee 3->- M20 NT2 148789 coding NT2 lactosa 9804 coding 20 mitocho chrl:23 minyltra ndrial 527722 nsferase membra 5 2 ne 20 homolo g (yeast) - chromos microtu chrl:38 ome 1 bule- 155278- ClorflO open actin >+chrl : 9- reading Crosslin Provide 397928 >MACF protein- ClorflO frame protein- king nee 90 1 54955 coding 9 109 23499 coding MACF1 factor 1 - calcium chrl7:3 post- channel, 784085 GPI voltage- 0->- attachm depende chrl7:3 PGAP3- ent to nt, beta Provide 733378 >CACN protein- proteins protein- CACNB 1 nee 8 Bl PGAP3 93210 coding PGAP3 3 782 coding 1 subunit F-box and WD repeat - domain myeloid chr4:15 containi /lympho 333245 ng 7, E3 id or 5->- ubiquiti mixed- chr7:15 FBXW7 n lineage Provide 205576 - protein- protein protein- leukemi nee 0 >MLL3 FBXW7 55294 coding FBXW7 ligase 58508 coding MLL3 a 3 testis +chr6:4 develop 104082 nuclear ment 3- transcri related >+chr6: NFYA- ption 1 (non Provide 403470 >TDRG protein- factor miscRN protein nee 2 1 1 4800 coding NFYA Y, alpha 732253 A TDRG1 coding) regulati on of +chrl8: nuclear 396295 phospho pre- 69->- PIK3C3 inositide mRNA chrl8:3 - -3- domain Provide 361380 >RPRD protein- kinase, protein- RPRD1 containi nee 0 1A PIK3C3 5289 coding PIK3C3 class 3 55197 coding A ng 1A +chrl9: 838658 unchara 7->- RPS28- ribosom cterized chrl6:5 >LOCl al LOC10 LOC10 Provide 211847 005056 protein- protein 100505 miscRN 050561 050561 nee 8 19 6234 coding RPS28 S28 619 A 9 9

chr5:17 cadheri 583725 n- 8- related >+chr5: CLTB- clathrin, family Provide 175995 >CDHR protein- light protein- member nee 679 2 1212 coding CLTB chain B 54825 coding CDHR2 2

chr5:58 phospho 284320- diestera >+chr5: se 4D, Provide 522186 PDE4D- protein- cAMP- protein- integrin, nee 07 >ITGA1 PDE4D 5144 coding PDE4D specific 3672 coding ITGA1 alpha 1 rabaptin +chrl7: , RAB 525022 GTPase dynein, 0- RABEP binding axonem >+chrl7 1- effector al, Provide :1 15327 >DNAH RABEP protein- RABEP protein protein- heavy nee 34 9 1 9135 coding 1 1 1770 coding DNAH9 chain 9 +chrl7: RABEP rabaptin dynein, 525022 1- , RAB axonem Provide 0- >DNAH RABEP protein- RABEP GTPase protein- al, nee >+chrl7 9 1 9135 coding 1 binding 1770 coding DNAH9 heavy :1 15327 effector chain 9 34 protein 1 low density lipoprot +chrl 1: ein ankyrin 360577 receptor 3, node 99->- class A of chrl0:6 LDLRA domain Ranvier Provide 203939 D3- LDLRA protein- LDLRA containi protein- (ankyrin nee 7 >ANK3 D3 143458 coding D3 ng 3 288 coding ANK3 G) DIP2 disco- interacti ng long +chrl2: protein intergen 510346 2 ic non 35->- homolo protein chrl3:4 DIP2B- g B coding Provide 537916 >LINC0 protein- (Drosop miscRN LINCOO RNA nee 6 0330 DIP2B 57609 coding DIP2B hila) 144817 A 330 330 long chrl8:7 intergen 771072 ic non 4->- PQ loop protein chrl3:4 PQLC1- repeat coding Provide 537916 >LINC0 protein- containi miscRN LINCOO RNA nee 6 0330 PQLC1 80148 coding PQLC1 ng 1 144817 A 330 330 long chrl8:7 intergen 771072 ic non 4->- PQ loop protein chrl3:4 PQLC1- repeat coding Provide 537916 >LINC0 protein- containi miscRN LINCOO RNA nee 6 0330 PQLC1 80148 coding PQLC1 ng 1 144817 A 330 330 +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled Provide 100348 >GPR1 protein- fused protein- receptor nee 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled Provide 100348 >GPR1 protein- fused protein- receptor nee 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 low density +chrl 1: lipoprot solute 681331 ein carrier 70->- receptor family chrl l:6 LRP5- -related 22, Provide 286357 >SLC22 protein- protein protein- SLC22 member nee 8 A24 LRP5 4041 coding LRP5 5 283238 coding A24 24 protein +chrl0: phospha 133761 tase 2, 295->- PPP2R2 regulato chrl0:9 D- ry pantoth Provide 134422 >PANK PPP2R2 protein- PPP2R2 subunit protein- enate nee 2 1 D 55844 coding D B, delta 53354 coding PANK1 kinase 1 +chrl5: deleted 994428 insulin in 50- like colorect >+chrl8 growth al Provide :502784 IGF1R- protein- factor 1 protein- carcino nee 24 >DCC IGF1R 3480 coding IGF1R receptor 1630 coding DCC ma proprote chr20:l KIF16B kinesin in 655387 family convert Provide 4- >PCSK protein- member protein- ase nee >+chr20 2 KIF16B 55614 coding KIF16B 16B 5126 coding PCSK2 subtilisi

chr4:15 beta 259404 (DMPK 8 -like)

chrl4:5 ninein 113189 Salvador (GSK3 7->- homolo B chrl4:5 g interact! Provide 124552 SAV1- protein- (Drosop protein- nee 2 >NIN SAV1 60485 coding SAV1 hila) 51199 coding NEST protein) RAS- like, estrogen granzy chrl2:l me M 537036 regulate (lympho 3- RERG- d, cyte Provide >+chrl9 >GZM protein- growth protein- met-ase nee :547280 M RERG 85004 coding RERG inhibitor 3004 coding GZMM 1) leucine- chrl9:3 rich 598961 repeat 8->- LGI chrl9:3 family, Provide 561792 DMKN- protein- dermoid protein- member nee 1 >LGI4 DMKN 93099 coding DMKN ne 163175 coding LGI4 4

chr21:2 732690 amyloid chromo 4- beta some 2 1 >+chr21 APP- (A4) open Provide :305470 >C21orf protein- precurso protein- reading nee 33 7 351 coding APP r protein 5691 1 coding C21orf7 frame 7 membra ne bound growth O- +chr2:l regulati acyltran 168023 GREB1 on by sferase 4->- estrogen domain Provide chr2:90 >MBO protein- in breast protein- MBOA containi nee 98771 AT2 GREB1 9687 coding GREB1 cancer 1 129642 coding T2 ng 2

chrl2:l 164506 mediato 02->- MED 13 r kinesin chrl2:3 L- complex family Provide 976406 >KIF21 MED 13 protein- MED 13 subunit protein- member nee 3 A L 23389 coding L 13-like 55605 coding KIF21A 21A

chrl5:6 nuclear 869525 prelami 7- n A >+chrl7 ITGA1 1 recognit Provide :804178 protein- integrin, protein- ion nee 68 >NARF ITGA1 1 22801 coding ITGA1 1 alpha 11 26502 coding NARF factor

chrX:12 279949 3- THOC2 dedicato >+chrX: THO r of Provide 117676 >DOCK protein- complex protein- DOCK1 cytokin nee 688 11 THOC2 57187 coding THOC2 2 139818 coding 1 esis 11 pleckstr in homolo gy domain containi +chrl0: zinc g 316082 finger family F 21- E-box (with >+chr8: ZEB1- binding FYVE Provide 961662 >PLEK protein- homeob protein- PLEKH domain) nee 59 HF2 ZEB1 6935 coding ZEB1 ox 1 79666 coding F2 member 2 protein interfer - phospha on chrl9:5 tase 1, induced 561015 PPP1R1 regulato transme 2->- 2C- ry mbrane Provide chrl l:l >IFITM PPP1R1 protein- PPP1R1 subunit protein- IFITM1 protein nee 769349 10 2C 54776 coding 2C 12C 402778 coding 0 10 IQ motif - containi chrl5:4 ng 905925 GTPase 7- CEP 152 centroso activati >+chrl5 - mal ng Provide :909769 >IQGA protein- protein protein- IQGAP protein nee 5 1 PI CEP 152 22995 coding CEP 152 152kDa 8826 coding 1 1 solute carrier family N(alpha 19 )- chrl:16 (thiamin acetyltr 945480 e ansferas l->- SLC19 transpor e 50, chr3:l l A2- ter), NatE Provide 344294 >NAA5 SLC19 protein- SLC19 member protein- catalytic nee 2 0 A2 10560 coding A2 2 80218 coding NAA50 subunit calcium /calmod +chr5:l ulin- 749056 depende 42- nt >+chr5: SFXN1- protein Provide 110782 >CAM protein- siderofl protein- CAMK kinase nee 384 K4 SFXN1 94081 coding SFXN1 exin 1 814 coding 4 IV cAMP responsi +chr2:2 ve 084350 element transme 45->- CREB1- binding mbrane Provide chr2:98 >TME protein- protein protein- TMEM protein nee 543950 M131 CREB1 1385 coding CREB1 1 23505 coding 131 131 +chr6:l chromo 521294 some 6 99- open >+chr6: ESR1- estrogen reading Provide 151785 >C6orf2 protein- receptor protein- C6orf21 frame nee 588 11 2099 coding ESR1 1 79624 coding 1 2 11 UTP23, small subunit (SSU) process +chr8:l ome 177790 compon 30->- ent, RAD21 chr8:l l UTP23- homolo homolo Provide 787900 >RAD2 protein- g protein- g (S. nee 0 1 84294 coding UTP23 (yeast) 5885 coding RAD21 pombe) low density lipoprot ein receptor -related chrl6:8 protein 776037 KLHDC kelch associat l->- 4- domain ed Provide chr4:35 >LRPA KLHDC protein- KLHDC containi protein- LRPAP protein nee 26778 PI 4 54758 coding 4 ng 4 4043 coding 1 1 +chr7:7 LOC72 unchara glucoco 841374- 9852- cterized rticoid Provide >+chr7: >GLCC miscRN LOC72 LOC72 protein- GLCCI induced nee 804353 11 729852 A 9852 9852 113263 coding 1 transcri 8 pt l aryl- +chrl5: hydroca mesoder 807503 rbon m 17->- ARNT2 receptor develop chrl5:8 nuclear ment Provide 127452 >MESD protein- transloc protein- MESDC candidat nee 3 C2 ARNT2 9915 coding ARNT2 ator 2 23184 coding 2 e 2 N- acetyltra nsferase +chr8:l 1 806768 (arylami 9- ne N- DDHD >+chr8: NAT1- acetyltra domain Provide 380997 >DDHD protein- nsferase protein- containi nee 68 2 9 coding NAT1 ) 23259 coding DDHD2 ng 2 zinc +chr9:l finger 296230 and suppres 18->- BTB sor of chr9:12 ZBTB3 domain cancer Provide 781828 4- ZBTB3 protein- ZBTB3 containi protein- cell nee 6 >SCAI 4 403341 coding 4 ng 34 286205 coding SCAI invasion alpha thalasse ribosom mia/me al ntal protein chrX:76 retardati S6 907604- on kinase, >- ATRX- syndro 90kDa, Provide chrX:83 >RPS6 protein- me X- protein- RPS6K polypep nee 419395 KA6 ATRX 546 coding ATRX linked 27330 coding A6 tide 6 phospha tidylino chr9:10 sitol 311505 binding 4->- clathrin chrl l:8 TEX10- testis assembl Provide 574265 >PICAL protein- expresse protein- PICAL y nee 3 M TEX10 54881 coding TEX10 d 10 8301 coding M protein FYVE, RhoGE +chr3:l F and 496034 PH 0->- domain Provide chr4:75 FGD5- protein- containi protein- betacell nee 673359 >BTC FGD5 152273 coding FGD5 ng 5 685 coding BTC ulin

chr3:42 growth 744071- hedgeho factor >- g receptor chrl7:7 acyltran -bound Provide 332887 HHATL protein- sferase- protein- protein nee 8 ->GRB2 HHATL 57467 coding HHATL like 2885 coding GRB2 2 golgi- associat tR A ed PDZ methyltr chr6:l l and ansferas 792316 coiled- e 11 7- coil homolo >+chr6: GOPC- motif g (S. Provide 126359 >TRMT protein- containi protein- TRMT1 cerevisi nee 851 11 GOPC 57120 coding GOPC ng 60487 coding 1 ae)

chr9:14 zinc 693227- finger, >- ZDHHC DHHC- high chrl3:3 21- type mobility Provide 103783 >HMG protein- ZDHHC containi protein- HMGB group nee 1 Bl 340481 coding 2 1 ng 2 1 3146 coding 1 box 1 +chr9:9 SUSD3- sushi Provide 5821 11 >KIAA protein- domain protein- KIAA1 KIAA1 nee 2->- 1429 SUSD3 203328 coding SUSD3 containi 25962 coding 429 429 chr8:95 ng 3 511734 glioblast piccolo +chr7:5 oma (presyn 603239 amplifie aptic 4->- d cytomat Provide chr7:82 GBAS- protein- sequenc protein- rix nee 595803 >PCLO GBAS 2631 coding GBAS e 27445 coding PCLO protein) +chr6:l RAB2A 582444 78- member >+chr8: SNX9- RAS Provide 615311 >RAB2 protein- sorting protein- oncogen nee 39 A 51429 coding SNX9 nexin 9 5862 coding RAB2A e family trans for ming, acidic chrl0:l coiled- 017695 coil 95- DNMB dynami containi >+chrl0 P- n Provide :123954 >TACC DNMB protein- DNMB binding protein- protein nee 555 2 P 23268 coding P protein 10579 coding TACC2 2 ras responsi +chr6:7 ve 108001- element >+chr6: binding Provide 755595 RREB1- protein- protein protein- desmopl nee 1 >DSP RREB1 6239 coding RREB1 1 1832 coding DSP akin +chrl :1 118335 72- zinc >+chr7: CHIA- finger Provide 642918 >ZNF13 protein- chitinas protein- protein nee 29 8 27159 coding CHIA e, acidic 7697 coding ZNF138 138 split hand/fo ot chrl9:3 malfor 795621 Z F569 zinc mation 5->- finger (ectroda Provide chr7:96 >SHFM protein- protein protein- ctyly) nee 324203 1 ZNF569 148266 coding ZNF569 569 7979 coding SHFM1 type 1 breast chrl7:5 carcino 709297 ma 1- TREVI3 tripartite amplifie >+chrl7 7- motif d :587865 >BCAS protein- TREVI3 containi protein- sequenc Rush 80 3 4591 coding 7 ng 37 54828 coding BCAS3 e 3 peptidyl +chr22: prolyl 220204 isomera 20- se >+chr22 (cyclop neurofib :300643 PPIL2- protein- hilin)- protein- romin 2 Rush 22 >NF2 23759 coding PPIL2 like 4771 coding NF2 (merlin) low density lipoprot ein receptor -related protein chrl:53 8, 746259- apolipo transme >- LRP8- protein mbrane chrl:54 >TME protein- e protein- TMEM protein Rush 275419 M48 7804 coding LRP8 receptor 55706 coding 48 48 +chrl7: LUC7L LUC7- 487971 3- like 3 HNF1 92->- >HNF1 protein- LUC7L (S. protein- homeob Rush chrl7:3 B 51747 coding 3 cere visi 6928 coding HNF1B o B 604739 ae) 5

chr8:l l 787882 5- RAD21 fer-1- >+chr8: RAD21- homolo like 6 124968 >FER1 protein- g (S. protein- (C. Rush 232 L6 5885 coding RAD21 pombe) 654463 coding FER1L6 elegans) +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled 100348 >GPR1 protein- fused protein- receptor Rush 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 adaptor- putative +chrl7: related unchara 339689 protein cterized 94->- AP2B1- complex protein chr7:96 >FLJ42 protein- 2, beta 1 protein- FLJ422 FLJ422 Rush 115729 280 163 coding AP2B1 subunit 401388 coding 80 80 +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled 100348 >GPR1 protein- fused protein- receptor Rush 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 +chr4:7 RUN 167013 and 3- FYVE >+chr4: RUFY3 domain mucin 713379 - protein- containi protein- 7, Rush 32 >MUC7 22902 coding RUFY3 ng 3 4589 coding MUC7 secreted +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled 100348 >GPR1 protein- fused protein- receptor Rush 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 +chr3:l 004389 G 02- protein- >+chr3 : TFG- TRK- coupled 100348 >GPR1 protein- fused protein- receptor Rush 442 28 TFG 10342 coding TFG gene 84873 coding GPR128 128 lethal +chrl7: giant 735219 larvae 06->- homolo chr3:13 LLGL2- g 2 144246 >CPNE protein- (Drosop protein- copine Rush 9 4 3993 coding LLGL2 hila) 131034 coding CPNE4 IV sema domain, immuno globulin domain (Ig), transme brain mbrane and domain reprodu (TM) ctive and organ- - short express chr2:97 cytoplas ed 527316- mic (T FR >+chr2: SEMA4 domain, SF1A 285613 C- SEMA4 protein- SEMA4 (semaph protein- modulat Rush 17 >BRE C 54910 coding C orin) 4C 9577 coding BRE or) +chr6:l A 522019 kinase 06- ESR1- estrogen (PRKA) >+chr6: >AKAP protein- receptor protein- AKAP1 anchor Rush 151669 12 2099 coding ESR1 1 9590 coding 2 protein 846 12 amyloid beta precurso r protein chrl7:5 (cytopla 857776 smic 0- tail) kinesin >+chrl7 APPBP binding family :723453 2- protein- APPBP protein protein- member Rush 23 >KIF19 10513 coding 2 2 124602 coding KIF19 19 ADAM +chr8:3 metallo 888340 peptidas ankyrin 3->- ADAM e 1, chr8:41 9- protein- ADAM domain protein- erythroc Rush 585524 >ANK1 8754 coding 9 9 286 coding ANK1 ytic

chrl7:2 slingsho 749296 t 0->- homolo chrl7:2 MY018 g 2 812095 A- protein- MY018 myosin protein- (Drosop Rush 5 >SSH2 399687 coding A XVIIIA 85464 coding SSH2 hila) pleckstri n homolo gy domain containi ng, guanine family nucleoti A de (phosph binding oinositi protein +chr7:3 de (G 011374 binding protein), 8->- PLEKH specific) q chr9:80 A8- protein- PLEKH member protein- polypep Rush 537261 >GNAQ 84725 coding A8 8 2776 coding GNAQ tide F-box chrl7:3 and 745338 leucine- N- 0- rich ethylma >+chrl7 repeat leimide- :447517 FBXL2 protein- FBXL2 protein protein- sensitiv Rush 80 0->NSF 84961 coding 0 20 4905 coding NSF e factor breast chrl7:5 carcino 709465 ma 7- TRIM3 tripartite amplifie >+chrl7 7- motif d :587865 >BCAS protein- TRIM3 containi protein- sequenc Rush 80 3 4591 coding 7 ng 37 54828 coding BCAS3 e 3 DnaJ zinc (Hsp40) chr20:6 finger homolo 2421 17 and 4- ZBTB4 BTB subfami >+chr20 6- domain ly c , :625596 >DNAJ protein- ZBTB4 containi protein- DNAJC member Rush 88 C5 140685 coding 6 ng 46 80331 coding 5 5 +chr6:l A 522019 kinase 06- (PRKA) >+chr6: ESR1- estrogen anchor 151669 >AKAP protein- receptor protein- AKAP1 protein Rush 846 12 ESR1 2099 coding ESR1 1 9590 coding 2 12

TABLE B Gene Chimera Sequence SEQ ID Fusion NO. LRP5-> ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTG SEQ ID KAT6A CTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCGGATGGTAAAACT NO: l CGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAA AAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTC ATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTT AAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAA GATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGA AAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGC AGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACG TTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCC TCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACG GCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCA ACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTC CCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGT AGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGA ACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAG TTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATC GAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAA CATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGAT CCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGA CCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAA ACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAAC AAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAA GGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCAT CAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATA GCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCC TTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAG TGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAA TCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAA CAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAA AGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGG AGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTT GGGAAGTATGAAATTCACACCTGGTACTCCTCCCCATATCCTCAAGAATAC TCAAGGCTGCCCAAATTGTATCTTTGTGAATTTTGTCTAAAATATATGAAAA GTAGAACTATTCTGCAGCAGCACATGAAGAAATGTGGTTGGTTCCATCCTC CTGCCAATGAGATTTACAGAAAGAATAATATTTCTGTCTTTGAGGTTGATGG GAATGTGAGTACCATTTATTGTCAAAACCTGTGTCTTTTGGCAAAGTTGTTT CTTGACCACAAAACCCTCTATTACGATGTGGAGCCATTTCTTTTTTATGTAC TAACACAGAATGATGTCAAGGGCTGCCACCTTGTTGGCTACTTTTCTAAGG AAAAGCACTGCCAACAGAAGTACAATGTTTCCTGTATAATGATTCTTCCTCA ATACCAGCGTAAGGGCTATGGCAGGTTTCTCATCGATTTCAGTTATTTGTTA TCAAAGCGTGAAGGCCAAGCAGGGTCTCCAGAGAAACCGTTATCTGATCTG GGTCGTCTTTCCTACATGGCATATTGGAAAAGTGTAATATTGGAGTGCCTTT ATCACCAAAATGACAAGCAGATCAGCATTAAGAAGTTAAGCAAGTTGACTG GAATCTGCCCTCAAGACATCACTTCCACACTCCACCACCTACGAATGCTGG ACTTCCGTAGTGACCAATTTGTGATTATCCGCCGGGAAAAACTTATCCAGG ATCACATGGCAAAGCTTCAGCTGAATTTGCGACCTGTAGATGTAGATCCAG AATGTTTGCGCTGGACTCCAGTCATAGTGTCCAACTCTGTGGTCTCAGAGGA GGAAGAAGAGGAGGCTGAGGAAGGAGAAAACGAAGAGCCACAGTGCCAG GAAAGAGAATTAGAGATCAGTGTGGGAAAGTCTGTGTCTCATGAGAACAA AGAACAAGATTCTTATTCAGTAGAAAGTGAAAAGAAACCAGAAGTTATGG CTCCAGTCAGTTCTACACGTTTGAGCAAACAAGTCCTTCCTCATGATAGTCT TCCTGCAAATAGCCAGCCATCTCGGAGGGGCCGCTGGGGGAGGAAGAACA GAAAAACCCAGGAACGTTTTGGTGATAAAGATTCTAAACTGCTCTTGGAAG AGACGTCTTCAGCTCCTCAGGAACAATATGGAGAATGTGGGGAGAAATCAG AAGCCACCCAGGAACAATACACTGAAAGTGAAGAACAGCTGGTGGCTTCT GAGGAGCAGCCAAGCCAGGACGGGAAACCTGACCTTCCCAAGAGAAGACT CAGTGAGGGGGTTGAGCCCTGGCGAGGACAGCTCAAGAAAAGCCCTGAGG CTCTGAAGTGCAGATTAACAGAAGGAAGTGAGAGGCTGCCCCGTCGCTACA GTGAGGGTGACAGGGCTGTCCTCAGGGGCTTCAGTGAGAGCAGCGAGGAG GAGGAGGAGCCGGAAAGCCCTCGGTCAAGCTCGCCACCAATTCTCACAAA GCCCACGCTGAAGCGAAAGAAACCATTTCTCCACCGAAGGAGGAGAGTCC GAAAGCGCAAACACCACAATAGCAGTGTAGTCACAGAAACTATTTCTGAGA CCACTGAAGTGTTAGATGAACCTTTTGAAGATTCTGACTCCGAGAGGCCAA TGCCAAGATTAGAACCCACGTTTGAGATCGATGAAGAAGAGGAGGAAGAG GATGAAAATGAACTTTTCCCTAGAGAATACTTCCGTCGTTTGTCTTCGCAGG ATGTACTCAGGTGTCAGTCCTCTTCTAAGAGGAAGTCTAAAGATGAAGAAG AAGATGAAGAGTCAGATGATGCTGATGACACTCCTATCTTAAAGCCAGTAT CTCTTTTGCGAAAACGTGATGTGAAGAATTCTCCTCTTGAGCCAGATACATC CACACCTTTGAAAAAGAAAAAGGGATGGCCCAAAGGCAAGAGCCGCAAAC CAATCCACTGGAAGAAAAGACCTGGTCGAAAACCAGGATTTAAGTTGAGTC GGGAAATCATGCCAGTTTCTACTCAAGCATGCGTCATTGAGCCCATCGTTTC CATTCCTAAAGCTGGACGTAAACCCAAGATCCAGGAGAGTGAAGAAACTGT TGAGCCAAAAGAAGACATGCCCCTACCCGAGGAGAGGAAGGAGGAGGAGG AGATGCAAGCAGAGGCAGAAGAGGCTGAAGAGGGTGAGGAAGAGGATGC AGCCAGCAGTGAAGTCCCAGCAGCCTCTCCAGCAGACAGCAGCAATAGTCC TGAGACCGAAACCAAGGAGCCTGAGGTGGAGGAGGAAGAAGAGAAGCCCC GTGTCTCAGAGGAGCAGAGGCAGTCAGAGGAGGAGCAGCAGGAATTAGAG GAGCCAGAGCCAGAGGAGGAGGAAGATGCAGCTGCAGAGACTGCCCAGAA TGACGACCACGACGCTGATGATGAGGATGATGGCCACCTGGAGTCCACAAA GAAAAAGGAGCTAGAGGAACAGCCCACGAGGGAAGATGTCAAGGAGGAG CCTGGTGTTCAAGAGTCTTTTTTAGATGCTAATATGCAGAAGAGTAGGGAA AAGATAAAGGATAAAGAGGAAACCGAGCTGGATTCCGAAGAGGAGCAGCC TTCCCATGACACGTCCGTGGTGTCAGAGCAGATGGCTGGGTCTGAGGACGA CCACGAAGAAGACTCCCACACTAAGGAAGAGTTAATCGAATTAAAAGAGG AGGAAGAGATTCCTCATAGTGAGCTGGATCTGGAAACTGTACAGGCAGTGC AGTCTTTGACTCAAGAAGAAAGCAGTGAGCATGAGGGCGCCTACCAGGACT GTGAGGAAACTCTTGCGGCGTGTCAGACCCTGCAGAGTTACACCCAGGCTG ACGAGGACCCTCAGATGTCCATGGTTGAAGACTGTCATGCGTCAGAACATA ATAGCCCTATCTCCTCCGTTCAGTCTCACCCCAGCCAGTCAGTCCGTTCGGT CAGCAGTCCCAACGTGCCTGCCCTTGAGAGTGGCTACACCCAGATCAGCCC AGAACAAGGATCCCTGTCCGCACCCTCTATGCAGAACATGGAGACCAGCCC CATGATGGATGTGCCTTCCGTATCAGACCACTCTCAGCAGGTGGTGGACAG CGGCTTCAGTGACCTGGGCAGCATTGAGAGCACCACTGAAAACTATGAGAA CCCAAGCAGTTACGACTCCACGATGGGCGGCAGCATCTGTGGGAACAGCTC TTCCCAGAGCAGCTGCTCCTACGGTGGGCTGTCGTCCTCCAGCAGCCTCACC CAGAGCAGCTGTGTGGTCACTCAGCAGATGGCCAGCATGGGCAGCAGCTGC AGCATGATGCAGCAGAGCAGCGTCCAGCCTGCTGCCAACTGCAGCATCAAG TCACCTCAGAGCTGCGTGGTGGAGAGGCCTCCCAGTAACCAGCAGCAGCAG CCGCCACCACCGCCTCCACAGCAGCCACAGCCGCCGCCGCCACAACCACAA CCAGCACCACAGCCTCCACCACCCCAGCAGCAGCCGCAACAGCAGCCGCA GCCTCAGCCCCAGCAGCCTCCACCCCCACCCCCTCCCCAGCAGCAGCCCCC GCTGTCACAGTGTAGTATGAATAACAGTTTCACCCCAGCTCCTATGATCATG GAGATACCAGAATCTGGAAGCACTGGGAACATAAGTATCTATGAGAGGATT CCAGGGGATTTTGGTGCCGGCAGCTACTCTCAACCATCAGCCACCTTCAGC CTAGCCAAGCTGCAGCAGCTGACCAACACCATTATGGACCCTCATGCCATG CCTTATAGCCATTCTCCTGCTGTGACTTCCTATGCAACCAGTGTTTCTCTGTC CAATACAGGACTGGCTCAGCTGGCTCCATCTCATCCCTTAGCTGGGACTCCT CAAGCACAAGCCACCATGACGCCACCCCCAAACTTGGCATCCACTACCATG AACCTCACATCTCCTCTGCTTCAGTGCAACATGTCTGCCACCAACATTGGCA TTCCTCACACGCAGAGATTGCAAGGGCAAATGCCAGTGAAGGGGCACATTT CCATCCGCTCCAAGTCTGCGCCACTGCCCTCTGCGGCTGCTCACCAGCAGC AGCTGTATGGCCGTAGCCCATCGGCAGTTGCCATGCAGGCTGGCCCTCGCG CACTGGCTGTTCAGCGTGGCATGAACATGGGGGTTAATCTGATGCCTACTC CCGCCTATAATGTCAATTCCATGAATATGAACACCTTGAATGCCATGAACA GCTATCGAATGACACAGCCCATGATGAACAGCAGTTACCATAGTAACCCTG CCTACATGAACCAGACAGCACAGTATCCTATGCAGATGCAGATGGGAATGA TGGGGAGCCAGGCCTATACCCAGCAGCCTATGCAGCCTAACCCTCATGGGA ACATGATGTACACAGGCCCCTCCCATCACAGCTACATGAACGCTGCTGGCG TGCCCAAGCAGTCACTCAACGGACCTTACATGAGAAGATGA ESRl-> ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAG SEQ ID ATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCC NO:2 AKAP12 CTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTG TACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCC AACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAG GCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGC GTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCA GCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATT CAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGAC AAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTG TGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCT GCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTC CAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAG GCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATA CGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAG ATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCT GCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGC CTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTG AGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGC TTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACAT GATCAACTGGGCGAAGAGGGTGCCAGTTGGACAGAGAGACTCTGAAGATG TGAGCAAAAGAGACTCCGATAAAGAGATGGCTACTAAGTCAGCGGTTGTTC ACGACATCACAGATGATGGGCAGGAGGAGACACCCGAAATAATCGAACAG ATTCCTTCTTCAGAAAGCAATTTAGAAGAGCTAACACAACCCACTGAGTCC CAGGCTAATGATATTGGATTTAAGAAGGTGTTTAAGTTTGTTGGCTTTAAAT TCACTGTGAAAAAGGATAAGACAGAGAAGCCTGACACTGTCCAGCTACTCA CTGTGAAGAAAGATGAAGGGGAGGGAGCAGCAGGGGCTGGCGACCACAAG GACCCCAGCCTTGGGGCTGGAGAAGCAGCATCCAAAGAAAGCGAACCCAA ACAATCTACAGAGAAACCCGAAGAGACCCTGAAGCGTGAGCAAAGCCACG CAGAAATTTCTCCCCCAGCCGAATCTGGCCAAGCAGTGGAGGAATGCAAAG AGGAAGGAGAAGAGAAACAAGAAAAAGAACCTAGCAAGTCTGCAGAATCT CCGACTAGTCCCGTGACCAGTGAAACAGGATCAACCTTCAAAAAATTCTTC ACTCAAGGTTGGGCCGGCTGGCGCAAAAAGACCAGTTTCAGGAAGCCGAA GGAGGATGAAGTGGAAGCTTCAGAGAAGAAAAAGGAACAAGAGCCAGAA AAAGTAGACACAGAAGAAGACGGAAAGGCAGAGGTTGCCTCCGAGAAACT GACCGCCTCCGAGCAAGCCCACCCACAGGAGCCGGCAGAAAGTGCCCACG AGCCCCGGTTATCAGCTGAATATGAGAAAGTTGAGCTGCCCTCAGAGGAGC AAGTCAGTGGCTCGCAGGGACCTTCTGAAGAGAAACCTGCTCCGTTGGCGA CAGAAGTGTTTGATGAGAAAATAGAAGTCCACCAAGAAGAGGTTGTGGCC GAAGTCCACGTCAGCACCGTGGAGGAGAGAACCGAAGAGCAGAAAACGGA GGTGGAAGAAACAGCAGGGTCTGTGCCAGCTGAAGAATTGGTTGAAATGG ATGCAGAACCTCAGGAAGCTGAACCTGCCAAGGAGCTGGTGAAGCTCAAA GAAACGTGTGTTTCCGGAGAGGACCCTACACAGGGAGCTGACCTCAGTCCT GATGAGAAGGTGCTGTCCAAACCCCCCGAAGGCGTTGTGAGTGAGGTGGA AATGCTGTCATCACAGGAGAGAATGAAGGTGCAGGGAAGTCCACTAAAGA AGCTTTTTACCAGCACTGGCTTAAAAAAGCTTTCTGGAAAGAAACAGAAAG GGAAAAGAGGAGGAGGAGACGAGGAATCAGGGGAGCACACTCAGGTTCCA GCCGATTCTCCGGACAGCCAGGAGGAGCAAAAGGGCGAGAGCTCTGCCTC ATCCCCTGAGGAGCCCGAGGAGATCACGTGTCTGGAAAAGGGCTTAGCCGA GGTGCAGCAGGATGGGGAAGCTGAAGAAGGAGCTACTTCCGATGGAGAGA AAAAAAGAGAAGGTGTCACTCCCTGGGCATCATTCAAAAAGATGGTGACG CCCAAGAAGCGTGTTAGACGGCCTTCGGAAAGTGATAAAGAAGATGAGCT GGACAAGGTCAAGAGCGCTACCTTGTCTTCCACCGAGAGCACAGCCTCTGA AATGCAAGAAGAAATGAAAGGGAGCGTGGAAGAGCCAAAGCCGGAAGAA CCAAAGCGCAAGGTGGATACCTCAGTATCTTGGGAAGCTTTAATTTGTGTG GGATCATCCAAGAAAAGAGCAAGGAGAGGGTCCTCTTCTGATGAGGAAGG GGGACCAAAAGCAATGGGAGGAGACCACCAGAAAGCTGATGAGGCCGGAA AAGACAAAGAGACGGGGACAGACGGGATCCTTGCTGGTTCCCAAGAACAT GATCCAGGGCAGGGAAGTTCCTCCCCGGAGCAAGCTGGAAGCCCTACCGA AGGGGAGGGCGTTTCCACCTGGGAGTCATTTAAAAGGTTAGTCACGCCAAG AAAAAAATCAAAGTCCAAGCTGGAAGAGAAAAGCGAAGACTCCATAGCTG GGTCTGGTGTAGAACATTCCACTCCAGACACTGAACCCGGTAAAGAAGAAT CCTGGGTCTCAATCAAGAAGTTTATTCCTGGACGAAGGAAGAAAAGGCCAG ATGGGAAACAAGAACAAGCCCCTGTTGAAGACGCAGGGCCAACAGGGGCC AACGAAGATGACTCTGATGTCCCGGCCGTGGTCCCTCTGTCTGAGTATGAT GCTGTAGAAAGGGAGAAAATGGAGGCACAGCAAGCCCAAAAAAGCGCAG AGCAGCCCGAGCAGAAGGCAGCCACTGAGGTGTCCAAGGAGCTCAGCGAG AGTCAGGTTCATATGATGGCAGCAGCTGTCGCTGACGGGACGAGGGCAGCT ACCATTATTGAAGAAAGGTCTCCTTCTTGGATATCTGCTTCAGTGACAGAAC CTCTTGAACAAGTAGAAGCTGAAGCCGCACTGTTAACTGAGGAGGTATTGG AAAGAGAAGTAATTGCAGAAGAAGAACCCCCCACGGTTACTGAACCTCTGC CAGAGAACAGAGAGGCCCGGGGCGACACGGTCGTTAGTGAGGCGGAATTG ACCCCCGAAGCTGTGACAGCTGCAGAAACTGCAGGGCCATTGGGTGCCGAA GAAGGAACCGAAGCATCTGCTGCTGAAGAGACCACAGAAATGGTGTCAGC AGTCTCCCAGTTAACCGACTCCCCAGACACCACAGAGGAGGCCACTCCGGT GCAGGAGGTGGAAGGTGGCGTACCTGACATAGAAGAGCAAGAGAGGCGGA CTCAAGAGGTCCTCCAGGCAGTGGCAGAAAAAGTGAAAGAGGAATCCCAG CTGCCTGGCACCGGTGGGCCAGAAGATGTGCTTCAGCCTGTGCAGAGAGCA GAGGCAGAAAGACCAGAAGAGCAGGCTGAAGCGTCGGGTCTGAAGAAAGA GACGGATGTAGTGTTGAAAGTAGATGCTCAGGAGGCAAAAACTGAGCCTTT TACACAAGGGAAGGTGGTGGGGCAGACCACCCCAGAAAGCTTTGAAAAAG CTCCTCAAGTCACAGAGAGCATAGAGTCCAGTGAGCTTGTAACCACTTGTC AAGCCGAAACCTTAGCTGGGGTAAAATCACAGGAGATGGTGATGGAACAG GCTATCCCCCCTGACTCGGTGGAAACCCCTACAGACAGTGAGACTGATGGA AGCACCCCCGTAGCCGACTTTGACGCACCAGGCACAACCCAGAAAGACGA GATTGTGGAAATCCATGAGGAGAATGAGGTCGCATCTGGTACCCAGTCAGG GGGCACAGAAGCAGAGGCAGTTCCTGCACAGAAAGAGAGGCCTCCAGCAC CTTCCAGTTTTGTGTTCCAGGAAGAAACTAAAGAACAATCAAAGATGGAAG ACACTCTAGAGCATACAGATAAAGAGGTGTCAGTGGAAACTGTATCCATTC TGTCAAAGACTGAGGGGACTCAAGAGGCTGACCAGTATGCTGATGAGAAA ACCAAAGACGTACCATTTTTCGAAGGACTTGAGGGGTCTATAGACACAGGC ATAACAGTCAGTCGGGAAAAGGTCACTGAAGTTGCCCTTAAAGGTGAAGG GACAGAAGAAGCTGAATGTAAAAAGGATGATGCTCTTGAACTGCAGAGTC ACGCTAAGTCTCCTCCATCCCCCGTGGAGAGAGAGATGGTAGTTCAAGTCG AAAGGGAGAAAACAGAAGCAGAGCCAACCCATGTGAATGAAGAGAAGCTT GAGCACGAAACAGCTGTTACCGTATCTGAAGAGGTCAGTAAGCAGCTCCTC CAGACAGTGAATGTGCCCATCATAGATGGGGCAAAGGAAGTCAGCAGTTTG GAAGGAAGCCCTCCTCCCTGCCTAGGTCAAGAGGAGGCAGTATGCACCAAA ATTCAAGTTCAGAGCTCTGAGGCATCATTCACTCTAACAGCGGCTGCAGAG GAGGAAAAGGTCTTAGGAGAAACTGCCAACATTTTAGAAACAGGTGAAAC GTTGGAGCCTGCAGGTGCACATTTAGTTCTGGAAGAGAAATCCTCTGAAAA AAATGAAGACTTTGCCGCTCATCCAGGGGAAGATGCTGTGCCCACAGGGCC CGACTGTCAGGCAAAATCGACACCAGTGATAGTATCTGCTACTACCAAGAA AGGCTTAAGTTCCGACCTGGAAGGAGAGAAAACCACATCACTGAAGTGGA AGTCAGATGAAGTCGATGAGCAGGTTGCTTGCCAGGAGGTCAAAGTGAGTG TAGCAATTGAGGATTTAGAGCCTGAAAATGGGATTTTGGAACTTGAGACCA AAAGCAGTAAACTTGTCCAAAACATCATCCAGACAGCCGTTGACCAGTTTG TACGTACAGAAGAAACAGCCACCGAAATGTTGACGTCTGAGTTACAGACAC AAGCTCACGTGATAAAAGCTGACAGCCAGGACGCTGGACAGGAAACGGAG AAAGAAGGAGAGGAACCTCAGGCCTCTGCACAGGATGAAACACCAATTAC TTCAGCCAAAGAGGAGTCAGAGTCAACCGCAGTGGGACAAGCACATTCTG ATATTTCCAAAGACATGAGTGAAGCCTCAGAAAAGACCATGACTGTTGAGG TAGAAGGTTCCACTGTAAATGATCAGCAGCTGGAAGAGGTCGTCCTCCCAT CTGAGGAAGAGGGAGGTGGAGCTGGAACAAAGTCTGTGCCAGAAGATGAT GGTCATGCCTTGTTAGCAGAAAGAATAGAGAAGTCACTAGTTGAACCGAAA GAAGATGAAAAAGGTGATGATGTTGATGACCCTGAAAACCAGAACTCAGC CCTGGCTGATACTGATGCCTCAGGAGGCTTAACCAAAGAGTCCCCAGATAC AAATGGACCAAAACAAAAAGAGAAGGAGGATGCCCAGGAAGTAGAATTGC AGGAAGGAAAAGTGCACAGTGAATCAGATAAAGCGATCACACCCCAAGCA CAGGAGGAGTTACAGAAACAAGAGAGAGAATCTGCAAAGTCAGAACTTAC AGAATCTTAA SEMA4C- ATGGCCCCACACTGGGCTGTCTGGCTGCTGGCAGCAAGGCTGTGGGGCCTG SEQ ID > GGCATTGGGGCTGAGGTGTGGTGGAACCTTGTGCCGCGTAAGACAGTGTCT NO: 3 TCTGGGGAGCTGGCCACGGTAGTACGGCGGTTCTCCCAGACCGGCATCCAG BMS1 GACTTCCTGACACTGACGCTGACGGAGCCCACTGGGCTTCTGTACGTGGGC GCCCGAGAGGCCCTGTTTGCCTTCAGCATGGAGGCCCTGGAGCTGCAAGGA GCGATCTCCTGGGAGGCCCCCGTGGAGAAGAAGACTGAGTGTATCCAGAA AGGGAAGAACAACCAGACCGAGTGCTTCAACTTCATCCGCTTCCTGCAGCC CTACAATGCCTCCCACCTGTACGTCTGTGGCACCTACGCCTTCCAGCCCAAG TGCACCTACGTCAACATGCTCACCTTCACTTTGGAGCATGGAGAGTTTGAA GATGGGAAGGGCAAGTGTCCCTATGACCCAGCTAAGGGCCATGCTGGCCTT CTTGTGGATGGTGAGCTGTACTCGGCCACACTCAACAACTTCCTGGGCACG GAACCCATTATCCTGCGTAACATGGGGCCCCACCACTCCATGAAGACAGAG TACCTGGCCTTTTGGCTCAACGAACCTCACTTTGTAGGCTCTGCCTATGTAC CTGAGAGTGTGGGCAGCTTCACGGGGGACGACGACAAGGTCTACTTCTTCT TCAGGGAGCGGGCAGTGGAGTCCGACTGCTATGCCGAGCAGGTGGTGGCTC GTGTGGCCCGTGTCTGCAAGGGCGATATGGGGGGCGCACGGACCCTGCAGA GGAAGTGGACCACGTTCCTGAAGGCGCGGCTGGCATGCTCTGCCCCGAACT GGCAGCTCTACTTCAACCAGCTGCAGGCGATGCACACCCTGCAGGACACCT CCTGGCACAACACCACCTTCTTTGGGGTTTTTCAAGCACAGTGGGGTGACAT GTACCTGTCGGCCATCTGTGAGTACCAGTTGGAAGAGATCCAGCGGGTGTT TGAGGGCCCCTATAAGGAGTACCATGAGGAAGCCCAGAAGTGGGACCGCT ACACTGACCCTGTACCCAGCCCTCGGCCTGGCTCGTGCATTAACAACTGGC ATCGGCGCCACGGCTACACCAGCTCCCTGGAGCTACCCGACAACATCCTCA ACTTCGTCAAGAAGCACCCGCTGATGGAGGAGCAGGTGGGGCCTCGGTGG AGCCGCCCCCTGCTCGTGAAGAAGGGCACCAACTTCACCCACCTGGTGGCC GACCGGGTTACAGGACTTGATGGAGCCACCTATACAGTGCTGTTCATTGGC ACAGGAGACGGCTGGCTGCTCAAGGCTGTGAGCCTGGGGCCCTGGGTTCAC CTGATTGAGGAGCTGCAGCTGTTTGACCAGGAGCCCATGAGAAGCCTGGTG CTATCTCAGAGCAAGAAGCTGCTCTTTGCCGGCTCCCGCTCTCAGCTGGTGC AGCTGCCCGTGGCCGACTGCATGAAGTATCGCTCCTGTGCAGACTGTGTCCT CGCCCGGGACCCCTATTGCGCCTGGAGCGTCAACACCAGCCGCTGTGTGGC CGTGGGTGGCCACTCTGGATCTCTACTGATCCAGCATGTGATGACCTCGGA CACTTCAGGCATCTGCAACCTCCGTGGCAGTAAGAAAGATGTACAGAAAGG TGTTCTTACATGAAGAAGGGTGTGAAGGCTGAACAATCATGGATTTTTCTG ATCAATTGTGCTTTAGGAAATTATTGACAGTTTTGCACAGGTTCTTGAAAAC GTTATTTATAATGAAATCAACTAAAACTATTTTTGCTATAAGTTCTATAAGG TGCATAAAACCCTTAAATTCATCTAGTAGCTGTTCCCCCGAACAGGTTTATT TTAGTAAAAAAAAAAAAACAAAAAACAAAAACAAAAGATTTTTATCAAAT GTTATGATGCAAAAAAAGAAAAAGAAAAAAAAAAAGAAAAGAAAACTTC AATTTTCTGGGTATGCACAAAGACCATGAAGACTTATCCAAGTGCATGACC GGATTTTTGTGGTTTTGTTCATTTTGTGTTTAATTTGTGTTTTTTTTTTCCAGC TGTATGAAATGGGCTTTCTGAAGTTTAAATAGTCCGACTTCACCCATGGTGT TCTGTGCTTGCAGTGCGAGTGTTGCTGTAATTCAGTGTTGCCGTCAGTGTCT CTTTTCTTAGCTTTCTGTCTTTCTTTCAACGTAGTGTGAAGTGTCTTATCCTT TTCTATGAATTCCAATTTGCCTTAACTCTTTTGATGCTGTAGCTGTTTCAGTA AAAGTTAGTTCAAACTAATGATGTAGAATGCTTTGACCAAATGAGCTGGTC TATTATGCCTTGTAAAACAGCAGCATAGGGCTTTTAAAAGGTAGTCAATAA AAGTTGCTGAAATTTTGGCTTTTTTAAATATGTAGTAGGTGTTTTTAATGAT TTTTCACATAATGTGTAAGGTAGTGAAATGCAAGAAGGGAAAAATGTTTTG TGTGAAACACATTTTCTGACTGGGGAACTTTTATTAGGGTAAATTGTTTGTA AGGCTGTACGCCAACAGTTTCCTCTGATAGTTTGACTGATTTAGGATATCTG CTGTATGATGCAATGTAAAGTCTTTTTTGCCTTTTTTCAGGAAAAAAAAAAA GCTAACTTGATGTACTAGATTTAGTGTAGGTAGTGTTGGGGTTGGGGATGG GGGTGGGGGAGGGGAGTCACTGAATGTTTTGTCCTTCCTTTATACTAATGAT AGTGCTTTAGAATGAGAATTATGCCTGAAATCTGGCAAACCGAAAAATGTT GCTATTGCAACAAAGTGGCAAAAGCTAAAAGTAAGGATTTATCTTCAAACA TAAGCTGAGATAACGAATAGAAGCAAAACGATTGGCTACTAGCTCTCTCTC TCTCTCTCTATTAGGTAAATTTGAAAAATAAAAATGACTTGGCACTTTTAAA GGTAACTTCACCAAAGACCGAAGAGCCAGTAACCAGTAGCTCCAACTTGTC TCAGCATCACATCTTCTGTGCTCTTTATTTTTGCCGGACCAGTTTGCGGTTAG GAGAATGTGCCTTTTTTGTACCTTTGCATTTAGGTTTTATAATTTTAATTGAT GTATGGACACACACAAACAAAAAAGCATGAAGGAAGATTTGGATCCAAGC AGTGCCACACTTTACATCATCACTACAAGTGTTCAAGTGTAAAGAAAACCA ATTTTGAAACTATGAAATTCCTGATTCATAAATACACAGTTATTTCTACTTT AGTACATATAAGATAATTCACTGTTATTAAAGCTCTTTTATTAAGGCAATTG CATATGTTTTAAAAGCAATGGTAAATTAAGTTGTCTTCCAAAACTGTGTACT TGTCTGGTCAGCTGTGTATGATCAGTTATCTACCTCAGAGTCTATTTTCTTTT GTGCTGGGACAGGTTGCTGGCCCTCCCTGTTTCCACAGACCAAATCCTCCTA GCTCAGGAGCTAGGGCTAAGCAGTTATTTCTTTCAAGTATTTTTTAGTTCTT AAATTTTATGCTTGTATTTGATGATAGATGTCAGTGACATTTCATAGTTTCA AAAGTCCTTGCTGCTCTGAGAAGTGTAGATTCTAGTGAAAATTACATAGTC ATAAGAGAAATGTGTTTTTGTTTTTGTTTTTGTTTCATTTTTTTAAAGTTGTG GTATTATTGGTTCTATGCTCCCTGGAATATTACTGCTTTGTGAAAGTCCAGA CTGAACGCAGCACCCTCTGTGTACCTAGTACAGTTATAAACCTGGGTCTCTC ACTACTTGATATTTTTGCATTAGTTAAGACAGAAATTTGATAGCTCGGTTAG AGGGGAGGGGAAATCTGCTGCTAGAAATGTCTGAACTAAGTGCCATACTCG TCTGGGTAAGATTTGGGAAACATAACCTCTGTACATAAAAAAAAAAAAATC AGTTAAACATCACATAGTAGACAGCCATTAAATTATAAAAAAATTAATTTA TGAAGAAAGACCTTTTGTACAGATTGAAAAAAAAAGATTTTCATAGAGATA TCTATATGATCAAGAGAGTTAATTTTTTATTTTTGTTTTACTAGTGCCACAG ACTTGCCAGTGGTAACTTATTTGTCCGGTTCAAGATAACTCTGTAGTTTTCT TTCCTAGGACTTGTTGTTAAACGCCAAAAGACATTTTTGAACTGTACATTTG ATCAGATTGTTAGCTTTTCTGTTTTATTTCTTTTGAGAACCTTTGAATAAAAA ACATCTGAAATTTTA TRPSl-> TAATAGTGTTGGTGTCTTGAAACTGACGTAATGCGCGGAGACTGAGGTCCT SEQ ID EIF3H GACAAGCGATAACATTTCTGATAAAGACCCGATCTTACTGCAATCTCTAGC NO:4 GTCCTCTTTTTTGGTGCTGCTGGTTTCTCCAGACCTCGCGTCCTCTCGATTGC TCTCTCGCCTTCCTATTTCTTTTTTTTTTTTTTAAACAAAAAACAACACCCCC TCCCCTCTCCCACCCGGCACCGGGCACATCCTTGCTCTATTTCCTTTCTCTTT CTCTCTCTCTCTCTCTCTCTCTCTTTTTTAATAAGGGTGGGGGAGGGAAAGG GGGGGGAGGCAGGAAAGACCTTTTTCTCTCCCCCCCGCAATAATCCAAGAT CAACTCTGCAAACAACAGAAGACGGTTCATGGCTTTGGCCGCCGCGCCACC ATCTTTCGGGCTGCCGAGGGTGTTCTTGACGATTAATCAACAGTCCAATATC AGATGGAAATGATGCGGAGCCTTCGCCATGTAAACATTGATCATCTTCACG TGGGCTGGTATCAGTCCACATACTATGGCTCATTCGTTACCCGGGCACTCCT GGACTCTCAGTTTAGTTACCAGCATGCCATTGAAGAATCTGTCGTTCTCATT TATGATCCCATAAAAACTGCCCAAGGATCTCTCTCACTAAAGGCATACAGA CTGACTCCTAAACTGATGGAAGTTTGTAAAGAAAAGGATTTTTCCCCTGAA GCATTGAAAAAAGCAAATATCACCTTTGAGTACATGTTTGAAGAAGTGCCG ATTGTAATTAAAAATTCACATCTGATCAATGTCCTAATGTGGGAACTTGAA AAGAAGTCAGCTGTTGCAGATAAACATGAATTGCTCAGCCTTGCCAGCAGC AATCATTTGGGGAAGAATCTACAGTTGCTGATGGACAGAGTGGATGAAATG AGCCAAGATATAGTTAAATACAACACATACATGAGGAATACTAGTAAACA ACAGCAGCAGAAACATCAGTATCAGCAGCGTCGCCAGCAGGAGAATATGC AGCGCCAGAGCCGAGGAGAACCCCCGCTCCCTGAGGAGGACCTGTCCAAA CTCTTCAAACCACCACAGCCGCCTGCCAGGATGGACTCGCTGCTCATTGCA GGCCAGATAAACACTTACTGCCAGAACATCAAGGAGTTCACTGCCCAAAAC TTAGGCAAGCTCTTCATGGCCCAGGCTCTTCAAGAATACAACAACTAAGAA AAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTGAAGTCACACCAGG GCAACTCTTGGAAGAAATATATTTGCATATTGAAAAGCACAGAGGATTTCT TTAGTGTCATTGCCGATTTTGGCTATAACAGTGTCTTTCTAGCCATAATAAA ATAAAACAAAATCTTGACTGCTTGCTCATTTGA UCK2-> ATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGG SEQ ID TMCOl CGGCGAGCCCTTCCTTATAGGCGTCAGCGGGGGAACAGCTAGCGGCAAGA NO:5 ACATTCAGAAGATTCTCGGCCTTGCCCCTTCACGAGCCGCCACCAAGCAGG CAGGTGGATTTCTTGGCCCACCACCTCCTTCTGGGAAGTTCTCTTGA ATGGCGGAGCCGTCGGCGGCCACTCAGTCCCATTCCATCTCCTCGTCGTCCT SEQ ID TCGGAGCCGAGCCGTCCGCGCCCGGCGGCGGCGGGAGCCCAGGAGCCTGC NO: 6 CCCGCCCTGGGGACGAAGAGCTGCAGCTCCTCCTGTGCGGAATGGGTTGAA TGGCTTGCATCTGGCTTCTAAGGAAGGCCATGTGAAAATGGTGGTTGAACT TCTGCACAAAGAAATCATTCTAGAAACGACAACCAAGAAGGGGAACACGG CCCTGCACATCGCTGCTCTAGCCGGGCAGGATGAGGTGGTCCGGGAGCTTG TCAACTATGGAGCCAACGTCAACGCCCAGTCACAGAAAGGTTTTACACCCC TGTACATGGCAGCACAAGAGAACCACTTGGAAGTGGTTAAGTTTTTACTGG AAAATGGAGCTAACCAGAATGTAGCCACAGAAGACGGCTTCACGCCTCTGG CGGTAGCCCTGCAGCAGGGCCATGAGAACGTCGTCGCGCACCTCATCAACT ACGGCACCAAGGGGAAGGTGCGCCTCCCGGCCCTGCACATCGCGGCCCGC AACGACGACACGCGCACGGCTGCGGTGCTGCTGCAGAACGACCCCAACCC GGACGTGCTTTCCAAGACGGGATTCACGCCCCTGCACATTGCGGCTCACTA CGAGAACCTCAACGTGGCCCAGTTGCTCCTCAACAGAGGAGCCAGCGTCAA TTTCACACCACAGAACGGCATCACGCCACTGCACATCGCCTCCCGCAGGGG CAACGTGATCATGGTGCGGCTGCTGCTGGATCGGGGAGCCCAGATAGAAAC CAAGACCAAGGACGAATTGACACCTCTCCACTGTGCAGCTCGAAATGGGCA CGTGCGAATCTCAGAGATCCTGCTGGACCACGGGGCACCAATCCAAGCCAA AACCAAGAACGGCCTGTCCCCAATTCACATGGCGGCTCAGGGAGACCACCT CGACTGTGTCCGGCTCCTGTTGCAATACGACGCAGAGATAGACGACATCAC CCTGGACCACCTGACCCCACTCCACGTGGCTGCCCACTGTGGACACCACAG GGTGGCTAAGGTCCTTCTGGATAAAGGGGCCAAACCCAACTCCAGAGCCCT GAATGGCTTTACCCCCTTACACATCGCCTGCAAAAAGAACCACGTCCGTGT CATGGAGCTGCTGCTGAAGACGGGAGCCTCGATCGACGCGGTCACCGAGTC TGGCCTGACACCTCTCCACGTGGCCTCCTTCATGGGGCACCTTCCCATCGTG AAGAACCTCCTGCAGCGGGGGGCGTCGCCCAACGTCTCCAACGTGAAAGTG GAGACCCCGCTACACATGGCAGCCAGAGCCGGGCACACGGAAGTGGCCAA ATATTTACTCCAGAACAAAGCCAAAGTCAATGCCAAGGCCAAGGATGACCA GACCCCACTTCACTGTGCAGCTCGCATCGGCCACACAAACATGGTGAAGCT CCTGCTGGAAAATAACGCCAACCCCAACCTGGCCACCACCGCCGGGCACAC CCCCCTGCACATTGCAGCCCGTGAGGGCCATGTGGAAACAGTCCTGGCCCT TCTGGAAAAGGAAGCATCCCAGGCCTGCATGACCAAGAAAGGATTTACCCC TCTGCACGTGGCGGCCAAGTACGGGAAGGTGCGGGTGGCAGAGCTGCTGCT GGAGCGGGACGCACACCCGAATGCTGCCGGAAAAAATGGCCTGACCCCCC TGCACGTGGCCGTCCATCACAACAACCTGGACATCGTCAAGCTGCTGCTTC CCCGGGGCGGCTCCCCGCACAGCCCTGCCTGGAATGGCTACACCCCTTTGC ACATCGCTGCCAAGCAGAACCAGGTGGAGGTGGCCCGTAGTCTGCTGCAGT ATGGGGGCTCAGCAAACGCCGAGTCGGTGCAAGGTGTGACGCCCCTTCACC TGGCCGCCCAGGAGGGCCACGCAGAGATGGTGGCTCTGCTGCTCTCGAAAC AAGCCAATGGCAACCTGGGGAACAAGAGCGGACTCACTCCCCTCCATCTGG TAGCACAAGAAGGCCACGTTCCAGTGGCAGATGTGCTGATCAAACACGGCG TCATGGTGGACGCCACCACCCGGATGGGCTACACTCCCCTCCATGTGGCCA GTCACTATGGAAACATCAAGCTGGTGAAGTTTCTGCTGCAGCACCAGGCAG ATGTCAATGCCAAGACCAAGCTAGGATACAGCCCCCTGCACCAGGCAGCCC AGCAGGGACACACAGACATCGTGACTCTGCTTCTGAAAAACGGTGCTTCCC CAAACGAGGTCAGCTCGGATGGAACCACACCTCTGGCCATAGCCAAGCGCT TGGGCTACATTTCTGTCACCGACGTGCTCAAGGTCGTCACGGATGAAACCA GTTTCGTGTTAGTCAGTGATAAGCATCGAATGAGTTTCCCTGAGACAGTTGA TGAGATCCTGGATGTCTCGGAAGATGAAGGGGAAGAACTCATCAGCTTCAA GGCTGAGAGGCGGGATTCCAGGGATGTTGATGAAGAGAAGGAGCTGCTGG ATTTTGTGCCGAAGCTAGACCAAGTGGTGGAATCTCCAGCCATCCCCAGGA TTCCCTGTGCCATGCCTGAGACAGTGGTGATCAGGTCAGAAGAGCAGGAGC AGGCATCTAAAGAGTATGATGAGGACTCCCTCATCCCCAGCAGCCCGGCCA CCGAGACCTCAGACAACATCAGCCCGGTGGCCAGCCCGGTGCATACAGGGT TTCTGGTGAGCTTCATGGTTGACGCCCGGGGTGGTTCCATGAGAGGAAGTC GCCACAACGGCCTGCGAGTGGTGATCCCGCCACGGACGTGCGCAGCGCCCA CCCGCATCACCTGCCGCCTGGTCAAGCCCCAGAAGCTCAGCACGCCGCCCC CACTGGCCGAGGAGGAGGGCCTGGCCAGCAGGATCATAGCACTGGGGCCC ACGGGGGCACAGTTCCTGAGCCCTGTAATCGTGGAGATCCCGCACTTTGCC TCCCATGGCCGTGGAGACCGCGAGCTCGTGGTTCTGAGGAGCGAAAACGGC TCCGTGTGGAAGGAGCACAGGAGCCGCTATGGAGAGAGCTACCTGGATCA GATCCTCAACGGGATGGACGAAGAGCTGGGGAGCCTGGAGGAGCTAGAGA AGAAGAGGGTGTGCCGAATCATCACCACCGACTTCCCGCTGTACTTCGTGA TCATGTCACGGCTCTGCCAGGACTACGACACCATCGGTCCCGAAGGGGGCT CCCTGAAGAGCAAGCTGGTGCCCCTGGTACAGGCAACGTTCCCGGAGAATG CCGTCACCAAGAGAGTGAAGCTGGCTCTGCAGGCCCAGCCTGTCCCGGATG AGCTTGTCACTAAGCTCCTGGGCAACCAGGCCACATTCAGCCCCATTGTCA CCGTGGAGCCCCGGCGCCGGAAGTTCCACCGCCCCATTGGGCTTCGGATCC CACTACCTCCTTCCTGGACCGACAACCCGAGGGACAGCGGGGAGGGAGAC ACCACCAGCCTGCGCCTGCTTTGCAGCGTCATTGGAGGAACAGACCAAGCC CAGTGGGAAGACATAACAGGAACCACCAAACTTGTATATGCCAACGAGTG CGCCAACTTCACCACCAATGTCTCTGCCAGGTTTTGGCTGTCGGACTGTCCT CGGACTGCTGAGGCTGTGAACTTTGCCACCCTGCTGTACAAAGAGCTCACT GCAGTGCCCTACATGGCCAAATTCGTCATCTTTGCCAAGATGAATGACCCC CGAGAGGGGCGCCTGCGCTGCTACTGCATGACAGATGATAAAGTGGACAA GACCCTGGAGCAGCATGAGAACTTCGTGGAGGTGGCCCGGAGCAGGGACA TAGAGGTGTTGGAAGGAATGTCCCTGTTTGCAGAACTCTCTGGGAACCTGG TGCCTGTGAAGAAAGCTGCCCAGCAGCGGAGCTTCCACTTCCAGTCATTTC GGGAGAACCGTCTGGCCATGCCTGTAAAGGTGAGGGACAGCAGTCGAGAG CCGGGAGGGTCCCTGTCGTTTCTGCGCAAGGCGATGAAGTACGAGGACACC CAGCACATTCTCTGCCACCTGAACATCACCATGCCCCCCTGCGCCAAGGGA AGTGGAGCCGAAGATAGGAGAAGGACCCCGACGCCCCTGGCCCTGCGATA CAGCATTCTCAGTGAGTCCACACCAGGTTCTCTCAGTGGGACAGAGCAGGC AGAGATGAAGATGGCTGTTATCTCAGAGCACCTCGGTCTCAGCTGGGCAGA GTTGGCCCGGGAGCTGCAGTTCAGTGTGGAAGACATCAACAGGATCCGAGT GGAAAATCCCAACTCCCTGTTGGAGCAGAGTGTGGCCTTGCTGAACCTCTG GGTCATCCGTGAAGGCCAAAACGCAAACATGGAGAATCTGTACACAGCCCT GCAGAGCATTGACCGTGGCGAGATCGTGAACATGCTGGAGGGTTCCGGCCG ACAGAGCCGCAACTTGAAGCCAGACAGGCGGCACACCGACCGCGACTACT CGCTGTCACCCTCCCAGATGAATGGTTACTCCTCACTGCAGGACGAGCTGCT GTCCCCTGCCTCCCTGGGCTGTGCACTTTCCTCTCCGCTACGTGCAGACCAG TACTGGAATGAGGTGGCCGTCCTAGACGCCATCCCCTTGGCGGCCACGGAG CATGACACCATGCTGGAGATGTCTGACATGCAGGTGTGGTCTGCGGGCCTC ACGCCTTCTCTGGTCACTGCTGAGGACTCCTCTCTGGAGTGTAGCAAGGCTG AGGACTCTGATGCCACAGGTCACGAGTGGAAGTTGGAGGGGGCACTCTCAG AGGAACCGCGGGGCCCCGAGTTGGGCTCTCTGGAACTTGTGGAGGACGACA CAGTGGATTCAGATGCCACAAATGGCCTTATCGATTTGCTTGAACAGGAGG AAGGTCAGAGGTCAGAAGAGAAGCTGCCAGGTTCTAAGAGGCAGGATGAC GCGACAGGTGCAGGGCAGGACTCAGAGAATGAAGTGTCTCTTGTTTCAGGC CATCAGAGGGGGCAAGCCCGAATCACACATTCCCCCACCGTGAGTCAGGTG ACGGAGAGGAGTCAGGACAGACTGCAGGACTGGGATGCAGACGGCTCGAT TGTCTCATACCTGCAAGATGCTGCACAAGGTTCCTGGCAAGAGGAGGTCAC GCAAGGTCCACACTCATTCCAGGGAACAAGTACCATGACTGAAGGGCTAGA GCCCGGTGGATCTCAGGAGTACGAGAAGGTCCTGGTGTCTGTAAGTGAGCA CACGTGGACAGAACAGCCCGAGGCTGAGAGCTCCCAGGCCGACAGGGACC GGAGGCAGCAAGGCCAAGAAGAGCAGGTGCAGGAGGCCAAGAACACCTTC ACCCAAGTGGTGCAGGGGAATGAGTTTCAGAATATTCCAGGGGAGCAGGT GACAGAGGAGCAATTCACGGATGAGCAGGGCAACATTGTCACCAAGAAGA TCATTCGCAAGGTGGTTCGACAGATAGACTTGTCCAGCGCCGATGCCGCCC AGGAGCACGAGGAGGTGGAGCTGAGAGGGAGTGGCCTACAGCCGGACCTG ATAGAGGGCAGGAAGGGGGCGCAGATAGTGAAGCGGGCCAGCCTGAAAAG GGGGAAACAGTGA ACACA- ATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGGTCTTTCTGGAAGT SEQ ID > GGATATCTACTCAGACAGTAAGAATTATAAGAGCTGTAAGAGCTCATTTTG NO:7 MSI2 GAGGAATAATGGATGAACCATCTCCCTTGGCCCAACCTCTGGAGCTGAACC AGCACTCTCGATTCATAATAGGTTCTGTGTCTGAAGATAACTCAGAGGATG AGATCAGCAACCTGGTGAAGTTGGACCTACTGGAGGAGAAGGAGGGCTCC TTGTCACCTGCTTCTGTTGGCTCAGATACACTCTCTGATTTGGGGATCTCTA GCCTACAGGATGGCTTGGCCTTGCACATAAGGTCCAGCATGTCTGGCTTGC ACCTAGTAAAGCAGGGCCGAGACAGAAAGAAAATAGATTCTCAACGAGAT TTCACTGTGGCTTCTCCAGCAGAATTTGTTACTCGCTTTGGGGGAAATAAAG TGATTGAGAAGGTTCTTATTGCTAACAATGGCATTGCAGCAGTGAAATGCA TGCGGTCTATCCGTAGGTGGTCTTATGAAATGTTTCGAAATGAACGTGCAAT TAGATTCGTTGTCATGGTCACACCTGAAGACCTTAAAGCCAATGCAGAATA CATTAAGATGGCAGATCACTATGTGCCAGTGCCTGGAGGACCAAACAACAA CAACTATGCAAATGTGGAATTAATTCTTGATATTGCTAAAAGGATCCCAGT ACAAGCAGTGTGGGCTGGCTGGGGTCATGCTTCTGAGAATCCCAAACTACC GGAACTTCTCTTGAAAAATGGCATTGCCTTCATGGGTCCTCCAAGCCAGGC CATGTGGGCTTTAGGGGATAAGATTGCATCTTCCATAGTGGCTCAAACTGC AGGTATCCCAACTCTTCCCTGGAGCGGCAGTGGTCTTCGTGTGGACTGGCA GGAAAATGATTTTTCAAAACGTATCTTAAATGTTCCCCAGGAGCTATATGA AAAAGGTTATGTGAAAGATGTGGATGATGGGCTACAGGCAGCTGAGGAAG TTGGATATCCAGTAATGATCAAGGCCTCAGAGGGAGGAGGAGGGAAGGGA ATTAGAAAAGTCAACAATGCAGATGACTTCCCTAATCTCTTCAGACAGGTT CAAGCTGAAGTTCCTGGATCTCCCATATTTGTGATGAGACTAGCCAAACAA TCTCGTCATCTGGAGGTGCAGATCTTAGCGGACCAATATGGCAATGCTATCT CTTTGTTTGGTCGTGATTGCTCTGTACAACGCAGGCATCAGAAGATTATTGA AGAAGCACCTGCTACTATTGCTACTCCAGCAGTATTTGAACACATGGAACA GTGTGCGGTGAAACTTGCCAAAATGGTGGGTTATGTGAGTGCTGGGACTGT GGAATACCTGTACAGCCAGGATGGCAGCTTCTACTTTCTGGAATTGAATCCT CGGCTGCAGGTAGAGCACCCTTGTACAGAGATGGTGGCTGATGTCAATCTC CCTGCAGCACAGCTCCAGATTGCCATGGGGATTCCTCTATATAGAATCAAG GATATCCGTATGATGTATGGGGTATCTCCCTGGGGTGATTCTCCCATTGATT TTGAAGATTCTGCACACGTTCCTTGTCCAAGGGGCCATGTTATTGCTGCTCG GATCACTAGTGAAAATCCAGATGAGGGTTTTAAGCCCAGCTCAGGAACAGT TCAGGAGCTAAATTTCCGCAGCAATAAGAATGTTTGGGGATATTTCAGTGT TGCTGCTGCAGGGGGACTTCATGAATTTGCTGATTCTCAGTTTGGTCACTGC TTTTCTTGGGGAGAAAACAGAGAAGAGGCAATTTCAAACATGGTGGTGGCT TTGAAGGAGCTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTG ATCAAATTGTTAGAGACTGAAAGCTTTCAGATGAACAGAATTGATACTGGC TGGCTGGACAGACTGATAGCAGAAAAAGTACAGGCTGAGCGACCTGACAC CATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTGGCAGATGTGAGCCTGCG GAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTCCTTCCT GCTCATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTC AAGTATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATC ATGAATGGCTCATGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGA CTGCTCTTGTCCTATGATGGCAGCAGTTATACTACGTATATGAAAGAGGAA GTGGATAGATATCGCATCACAATTGGCAATAAAACCTGTGTGTTTGAGAAG GAAAATGACCCATCGGTGATGCGCTCACCTTCTGCTGGGAAGTTAATCCAG TACATTGTAGAAGATGGAGGTCATGTGTTTGCCGGCCAGTGCTATGCTGAG ATTGAGGTAATGAAGATGGTAATGACCTTAACAGCTGTGGAGTCTGGCTGT ATCCATTACGTCAAGCGACCTGGAGCAGCTCTTGACCCTGGCTGTGTACTA GCCAAAATGCAACTGGACAACCCCAGCAAGGTTCAGCAGGCTGAACTTCAC ACAGGTAGTCTGCCACGGATCCAGAGCACGGCACTCAGAGGCGAGAAACT CCATCGAGTGTTCCATTATGTCCTGGATAATCTGGTCAATGTAATGAATGGA TACTGCCTTCCAGATCCTTTCTTTAGCAGCAAGGTAAAAGACTGGGTAGAG CGATTGATGAAAACCCTCAGAGATCCCTCCCTGCCTCTCCTAGAATTGCAA GATATTATGACCAGTGTGTCTGGCCGCATTCCCCCCAATGTGGAGAAGTCT ATCAAGAAGGAAATGGCTCAGTATGCTAGCAACATCACATCAGTCCTCTGT CAGTTTCCCAGCCAGCAGATTGCAAACATCCTAGATAGCCATGCAGCTACA TTGAACCGGAAATCTGAACGGGAAGTCTTCTTTATGAATACTCAGAGCATT GTTCAGCTGGTACAGAGGTACCGAAGTGGCATCCGAGGCCACATGAAGGCT GTGGTGATGGATCTGCTCCGGCAGTACCTGCGAGTAGAGACACAATTCCAG AATGGTCACTATGACAAATGTGTATTCGCCCTCCGAGAAGAGAATAAAAGT GACATGAACACTGTACTGAACTACATCTTCTCTCACGCTCAAGTCACCAAG AAGAATCTTCTGGTCACAATGCTTATTGATCAGTTGTGTGGCCGGGACCCTA CTCTCACTGATGAGCTGCTGAATATTCTCACAGAGCTAACTCAACTCAGTAA GACCACCAATGCCAAAGTAGCACTTCGAGCACGCCAGGTTCTTATTGCCTC CCATTTGCCATCATATGAGCTTCGCCATAACCAAGTAGAGTCTATCTTCCTA TCAGCTATTGACATGTATGGACATCAATTTTGCATTGAGAACCTGCAGAAA CTCATCCTATCAGAAACATCTATTTTTGATGTCCTACCAAACTTCTTCTATCA CAGCAACCAAGTAGTGAGGATGGCAGCTCTGGAGGTGTATGTTCGAAGGGC TTATATTGCCTATGAACTTAACAGCGTACAACACCGCCAGCTTAAGGACAA CACCTGTGTGGTGGAATTCCAGTTCATGCTGCCCACATCTCATCCAAACAGA GGGAACATCCCTACGCTAAACAGAATGTCCTTCTCCTCCAACCTCAACCACT ATGGCATGACCCATGTAGCTAGTGTCAGCGATGTACTGTTGGACAACTCAT TCACTCCACCTTGTCAGCGGATGGGCGGAATGGTCTCTTTTCGGACTTTTGA AGATTTTGTCAGGATCTTTGATGAAGTGATGGGCTGCTTCTCTGACTCCCCA CCCCAGAGTCCCACATTCCCTGAGGCAGGTCACACGTCTCTTTATGATGAG GATAAGGTTCCCAGGGATGAACCAATTCACATTCTCAATGTGGCTATCAAG ACTGACTGTGATATTGAGGATGACAGGCTGGCAGCTATGTTCAGAGAATTT ACCCAGCAAAATAAAGCTACCCTGGTTGACCATGGGATCCGGCGCCTTACT TTCCTGGTTGCACAAAAGGATTTCAGAAAGCAGGTCAACTATGAGGTGGAT CGGAGATTTCATAGAGAATTCCCTAAATTTTTTACATTCCGAGCAAGGGAT AAGTTTGAGGAGGATCGTATCTATCGTCATCTGGAGCCTGCTCTGGCTTTCC AGTTAGAGCTGAACCGGATGAGAAATTTTGACCTCACTGCCATTCCATGTG CTAATCACAAGATGCACCTGTATCTCGGGGCAGCCAAGGTGGAAGTGGGCA CAGAAGTGACAGACTACAGGTTCTTTGTTCGTGCAATCATCAGGCATTCTG ATCTGGTCACCAAGGAAGCTTCTTTTGAATATCTGCAAAATGAAGGGGAGC GGCTACTCCTGGAAGCCATGGATGAGTTGGAAGTTGCTTTTAACAATACAA ATGTCCGCACTGACTGTAACCACATCTTCCTCAACTTTGTGCCCACGGTTAT CATGGACCCATCAAAGATTGAGGAATCCGTGCGGAGCATGGTAATGCGGTA TGGAAGTCGCCTGTGGAAATTGCGCGTCCTCCAGGCAGAACTGAAAATCAA CATTCGCCTGACGCCAACTGGAAAAGCAATTCCCATCCGCCTCTTCCTGACA AACGAGTCTGGCTATTACTTGGATATCAGCCTATACAAGGAAGTGACTGAC TCCAGGACAGCACAGATCATGTTTCAGGCATATGGAGACAAACAGGGACC ACTGCATGGAATGTTAATCAATACTCCATATGTGACCAAAGACCTGCTGCA ATCAAAGAGGTTCCAGGCACAATCCTTAGGGACAACATACATATATGATAT CCCAGAGATGTTTCGGCAGTCCCTGATCAAACTCTGGGAGTCTATGTCCACT CAAGCATTTCTTCCATCTCCCCCTCTGCCTTCTGACATGCTGACTTACACTG AACTGGTACTGGATGATCAAGGTCAGCTGGTCCACATGAACAGGCTTCCAG GAGGAAATGAGATGGTCACAAGAACAAAGAAAATATTTGTAGGCGGGTTA TCTGCGAACACAGTAGTGGAAGATGTAAAGCAATATTTCGAGCAGTTTGGC AAGGTGGAAGATGCAATGCTGATGTTTGATAAAACTACCAACAGGCACAG AGGGTTTGGCTTTGTCACTTTTGAGAATGAAGATGTTGTGGAGAAAGTCTGT GAGATTCATTTCCATGAAATCAATAATAAAATGGTAGAATGTAAGAAAGCT CAGCCGAAAGAAGTCATGTTCCCACCTGGGACAAGAGGCCGGGCCCGGGG ACTGCCTTACACCATGGACGCGTTCATGCTTGGCATGGGGATGCTGGGATA TCCCAACTTCGTGGCGACCTATGGCCGTGGCTACCCCGGATTTGCTCCAAGC TATGGCTATCAGTTCCCAGGCTTCCCAGCAGCGGCTTATGGACCAGTGGCA GCAGCGGCGGTGGCGGCAGCAAGAGGATCAGGCTCCAACCCGGCGCGGCC CGGAGGCTTCCCGGGGGCCAACAGCCCAGGACCTGTCGCCGATCTCTACGG CCCTGCCAGCCAGGACTCCGGAGTGGGGAATTACATAAGTGCGGCCAGCCC ACAGCCGGGCTCGGGCTTCGGCCACGGCATAGCTGGACCTTTGATTGCAAC GGCCTTTACAAATGGATACCATTGA DDX5-> ATGTCGGGTTATTCGAGTGACCGAGACCGCGGCCGGGACCGAGGGTTTGGT SEQ ID IQCG GCACCTCGATTTGGAGGAAGTAGGGCAGGGCCCTTATCTGGAAAGAAGTTT NO: 8 GGAAACCCTGGGGAGAAATTAGTTAAAAAGAAGTGGAATCTTGATGAGCT GCCTAAATTTGAGAAGAATTTTTATCAAGAGCACCCTGATTTGGCTAGGCG CACAGCACAAGAGGTGGAAACATACAGAAGAAGCAAGGAAATTACAGTTA GAGGTCACAACTGCCCGAAGCCAGTTCTAAATTTTTATGAAGCCAATTTCCC TGCAAATGTCATGGATGTTATTGCAAGACAGAATTTCACTGAACCCACTGC TATTCAAGCTCAGGGATGGCCAGTTGCTCTAAGTGGATTGGATATGGTTGG AGTGGCACAGACTGGATCTGGGAAAACATTGTCTTATTTGCTTCCTGCCATT GTCCACATCAATCATCAGCCATTCCTAGAGAGAGGCGATGGGCCTATTTGT TTGGTGCTGGCACCAACTCGGGAACTGGCCCAACAGGTGCAGCAAGTAGCT GCTGAATATTGTAGAGCATGTCGCTTGAAGTCTACTTGTATCTACGGTGGTG CTCCTAAGGGACCACAAATACGTGATTTGGAGAGAGGTGTGGAAATCTGTA TTGCAACACCTGGAAGACTGATTGACTTTTTAGAGTGTGGAAAAACCAATC TGAGAAGAACAACCTACCTTGTCCTTGATGAAGCAGATAGAATGCTTGATA TGGGCTTTGAACCCCAAATAAGGAAGATTGTGGATCAAATAAGACCTGATA GGCAAACTCTAATGTGGAGTGCGACTTGGCCAAAAGAAGTAAGACAGCTTG CTGAAGATTTCCTGAAAGACTATATTCATATAAACATTGGTGCACTTGAACT GAGTGCAAACCACAACATTCTTCAGATTGTGGATGTGTGTCATGACGTAGA AAAGGATGAAAAACTTATTCGTCTAATGGAAGAGATCATGAGTGAGAAGG AGAATAAAACCATTGTTTTTGTGGAAACCAAAAGAAGATGTGATGAGCTTA CCAGAAAAATGAGGAGAGATGGGTGGCCTGCCATGGGTATCCATGGTGAC AAGAGTCAACAAGAGCGTGACTGGGTTCTAAATGAATTCAAACATGGAAA AGCTCCTATTCTGATTGCTACAGATGTGGCCTCCAGAGGGCTAGATGTGGA AGATGTGAAATTTGTCATCAATTATGACTACCCTAACTCCTCAGAGGATTAT ATTCATCGAATTGGAAGAACTGCTCGCAGTACCAAAACAGGCACAGCATAC ACTTTCTTTACACCTAATAACATAAAGCAAGTGAGCGACCTTATCTCTGTGC TTCGTGAAGCTAATCAAGCAATTAATCCCAAGTTGCTTCAGTTGGTCGAAG ACAGAGGTTCAGAGTCAGAATGAGTATATTGCTAACCTCAAGGACCAACTG CAAGAGATGAAGGCAAAATCCAACTTGGAGAATCGCTACATGAAAACCAA TACCGAGCTGCAGATTGCCCAGACCCAGAAAAAGTGTAACAGAACAGAGG AACTCTTGGTGGAAGAGATTGAGAAACTCAGGATGAAAACCGAAGAAGAG GCCCGGACTCATACAGAGATTGAAATGTTCCTTAGAAAGGAGCAGCAGAA ACTTGAGGAGAGGCTGGAGTTCTGGATGGAGAAATACGATAAGGACACAG AAATGAAACAGAATGAACTAAATGCTCTCAAAGCCACAAAGGCCAGTGAC TTAGCACACCTTCAAGACCTGGCAAAGATGATAAGAGAGTATGAACAGGTC ATCATTGAAGATCGTATAGAAAAGGAGAGGAGCAAGAAGAAGGTAAAACA GGATCTCTTGGAATTAAAGAGCGTTATAAAGCTCCAGGCCTGGTGGCGAGG CACTATGATACGGAGAGAAATTGGTGGTTTCAAGATGCCTAAAGACAAAGT TGATAGCAAGGATTCAAAAGGCAAAGGTAAAGGCAAGGATAAGAGGAGAG GCAAGAAGAAGTGA PREXl-> ATGGAGGCGCCCAGCGGCAGCGAGCCCGGCGGCGACGGGGCCGGGGACTG SEQ ID SLC9A8 CGCCCACCCGGACCCCCGGGCCCCTGGCGCCGCGGCGCCCAGCTCCGGCCC NO:9 CGGCCCGTGCGCGGCCGCCCGGGAGTCCGAGCGCCAGCTGCGCCTCCGCCT CTGCGTCCTCAACGAGATCTTGGGCACCGAGAGGGACTACGTGGGCACCTT GCGCTTCTTGCAGTCGGCATTCCTGCATCGCATCCGGCAGAACGTGGCCGA CTCAGTGGAGAAGGGCCTCACGGAGGAGAATGTCAAGGTCCTGTTCTCGAA CATCGAAGACATCCTGGAAGTTCATAAGGATTTCTTGGCCGCCTTGGAGTA TTGTTTACACCCGGAGCCGCAGTCTCAGCATGAACTTGGGAATGTTTTCTTA AAATTCAAGGACAAGTTCTGCGTGTACGAGGAGTATTGCAGCAACCATGAG AAAGCCCTGAGGCTGCTGGTGGAGCTGAACAAGATCCCTACCGTGCGCGCC TTCCTTTTGAGCTGCATGCTTCTGGGAGGCCGGAAGACCACGGACATCCCTT TGGAAGGCTACCTGTTGTCTCCGATCCAGAGGATCTGCAAGTACCCGCTCCT CCTTAAGGAGCTGGCCAAGAGGACTCCCGGCAAGCACCCAGACCACCCCG CGGTCCAGAGTGCCCTGCAGGCCATGAAGACCGTTTGCTCCAACATCAATG AGACCAAGCGGCAGATGGAGAAGCTGGAAGCCCTGGAGCAGCTGCAGTCC CACATCGAAGGCTGGGAGGAGGTTCCCCAATACAACTCATGAGGGTTTCAA TGTCACCCTCCACACCACCCTGGTTGTCACGACGAAACTGGTGCTCCCGAC CCCTGGCAAGCCCATCCTCCCCGTGCAGACAGGGGAGCAGGCCCAGCAAG AGGAGCAGTCCAGCGGCATGACCATTTTCTTCAGCCTCCTTGTCCTAGCTAT CTGCATCATATTGGTGCATTTACTGATCCGATACAGATTACATTTCTTGCCA GAGAGTGTTGCTGTTGTTTCTTTAGGTATTCTCATGGGAGCAGTTATAAAAA TTATAGAGTTTAAAAAACTGGCGAATTGGAAGGAAGAAGAAATGTTTCGTC CAAACATGTTTTTCCTCCTCCTGCTTCCCCCTATTATCTTTGAGTCTGGATAT TCATTACACAAGGGTAACTTCTTTCAAAATATTGGTTCCATCACCCTGTTTG CTGTTTTTGGGACGGCAATCTCCGCTTTTGTAGTAGGTGGAGGAATTTATTT TCTGGGTCAGGCTGATGTAATCTCTAAACTCAACATGACAGACAGTTTTGC GTTTGGCTCCCTAATATCTGCTGTCGATCCAGTGGCCACTATTGCCATTTTC AATGCACTTCATGTGGACCCCGTGCTCAACATGCTGGTCTTTGGAGAAAGT ATTCTCAACGATGCAGTCTCCATTGTTCTGACCAACACAGCTGAAGGTTTAA CAAGAAAAAATATGTCAGATGTCAGTGGGTGGCAAACATTTTTACAAGCCC TTGACTACTTCCTCAAAATGTTCTTTGGCTCTGCAGCGCTCGGCACTCTCAC TGGCTTAATTTCTGCATTAGTGCTGAAGCATATTGACTTGAGGAAAACGCCT TCCTTGGAGTTTGGCATGATGATCATTTTTGCTTATCTGCCTTATGGGCTTGC AGAAGGAATCTCACTCTCAGGCATCATGGCCATCCTTTTCTCAGGCATCGTG ATGTCCCACTACACGCACCATAACCTCTCCCCAGTCACCCAGATCCTCATGC AGCAGACCCTCCGCACCGTGGCCTTCTTATGTGAAACATGTGTGTTTGCATT TCTTGGCCTGTCCATTTTTAGTTTTCCTCACAAGTTTGAAATTTCCTTTGTCA TCTGGTGCATAGTGCTTGTACTATTTGGCAGAGCGGTAAACATTTTCCCTCT TTCCTACCTCCTGAATTTCTTCCGGGATCATAAAATCACACCGAAGATGATG TTCATCATGTGGTTTAGTGGCCTGCGGGGAGCCATCCCCTATGCCCTGAGCC TACACCTGGACCTGGAGCCCATGGAGAAGCGGCAGCTCATCGGCACCACCA CCATCGTCATCGTGCTCTTCACCATCCTGCTGCTGGGCGGCAGCACCATGCC CCTCATTCGCCTCATGGACATCGAGGACGCCAAGGCACACCGCAGGAACAA GAAGGACGTCAACCTCAGCAAGACTGAGAAGATGGGCAACACTGTGGAGT CGGAGCACCTGTCGGAGCTCACGGAGGAGGAGTACGAGGCCCACTACATC AGGCGGCAGGACCTTAAGGGCTTCGTGTGGCTGGACGCCAAGTACCTGAAC CCCTTCTTCACTCGGAGGCTGACGCAGGAGGACCTGCACCACGGGCGCATC CAGATGAAAACTCTCACCAACAAGTGGTACGAGGAGGTACGCCAGGGCCC CTCCGGCTCCGAGGACGACGAGCAGGAGCTGCTCTGA TXLNA-> ATGAAGAACCAAGACAAAAAGAACGGGGCTGCCAAACAATCCAATCCAAA SEQ ID MARCH6 AAGCAGCCCAGGACAACCGGAAGCAGGACCCGAGGGAGCCCAGGAGCGG NO: 10 CCCAGCCAGGCGGCTCCTGCAGTAGAAGCAGAAGGTCCCGGCAGCAGCCA GGCTCCTCGGAAGCCGGAGGGGGCTCAAGCCAGAACGGCTCAGTCTGGGG CCCTTCGTGATGTCTCTGAGGAGCTGAGCCGCCAACTGGAAGACATACTGA GCACATACTGTGTGGACAATAACCAGGGGGGCCCCGGCGAGGATGGGGCA CAGGGTGAGCCGGCTGAACCCGAAGATGCAGAGAAGTCCCGGACCTATGT GGCAAGGAATGGGGAGCCTGAACCAACTCCAGTAGTCAATGGAGAGAAGG AACCCTCCAAGGGGGATCCAAACACAGAAGAGATCCGGCAGAGTGACGAG GTCGGAGACCGAGACCATCGAAGGCCACAGGAGAAGAAAAAAGCCAAGG GTTTGGGGAAGGAGATCACGTTGCTGATGCAGACATTGAATACTCTGAGTA CCCCAGAGGAGAAGCTGGCTGCTCTGTGCAAGAAGTATGCTGAACTGGTAC CTTGTGGGTCAACGACTCGTGAACTACGAACGGAAATCTGGCAAACAAGGC TCATCTCCACCACCTCCACAGTCATCCCAAGAATAA EIF2C3-> ATGGAAATCGGCTCCGCAGGACCCGCTGGGGCCCAGCCCCTACTCATGGTG SEQ ID ZP2 CCCAGAAGACCTGGCTATGGCACCATGGGCAAACCCATTAAACTGCTGGCT NO: 11 AACTGTTTTCAAGTTGAAATCCCAAAGATTGATGTCTACCTCTATGAGGTAG ATATTAAACCAGACAAGTGTCCTAGGAGAGTGAACAGGGAGGTGGTTGACT CAATGGTTCAGCATTTTAAAGTAACTATATTTGGAGACCGTAGACCAGTTTA TGATGGAAAAAGAAGTCTTTACACCGCCAATCCACTTCCTGTGGCAACTAC AGGGGTAGATTTAGACGTTACTTTACCTGGGGAAGGTGGAAAAGATCGACC TTTCAAGGTGTCAATCAAATTTGTCTCTCGGGTGAGTTGGCACCTACTGCAT GAAGTACTGACAGGACGGACCTTGCCTGAGCCACTGGAATTAGACAAGCCA ATCAGCACTAACCCTGTCCATGCCGTTGATGTGGTGCTACGACATCTGCCCT CCATGAAATACACACCTGTGGGGCGTTCATTTTTCTCCGCTCCAGAAGGATA TGACCACCCTCTGGGAGGGGGCAGGGAAGTGTGGTTTGGATTCCATCAGTC TGTTCGGCCTGCCATGTGGAAAATGATGCTTAATATCGATGTTTCTGCCACT GCCTTCTACAAAGCACAACCTGTAATTCAGTTCATGTGTGAAGTTCTTGATA TTCATAATATTGATGAGCAACCAAGACCTCTGACTGATTCTCATCGGGTAA AATTCACCAAAGAGATAAAAGGTTTGAAGGTTGAAGTGACTCATTGTGGAA CAATGAGACGGAAATACCGTGTTTGTAATGTAACAAGGAGGCCTGCCAGTC ATCAAACCTTTCCTTTACAGTTAGAAAACGGCCAAACTGTGGAGAGAACAG TAGCGCAGTATTTCAGAGAAAAGTATACTCTTCAGCTGAAGTACCCGCACC TTCCCTGTCTGCAAGTCGGGCAGGAACAGAAACACACCTACCTGCCACTAG AAGTCTGTAATATTGTGGCAGGGCAACGATGTATCAAGAAGCTAACAGACA ATCAGACTTCCACTATGATCAAGGCAACAGCAAGATCTGCACCAGATAGAC AAGAGGAAATTAGCAGATTGGTAAGAAGTGCAAATTATGAAACAGATCCA TTTGTTCAGGAGTTTCAATTTAAAGTTCGGGATGAAATGGCTCATGTAACTG GACGCGTACTTCCAGCACCTATGCTCCAGTATGGAGGACGGAATCGGACAG TAGCAACACCGAGCCATGGAGTATGGGACATGCGAGGGAAACAATTCCAC ACAGGAGTTGAAATCAAAATGTGGGCTATCGCTTGTTTTGCCACACAGAGG CAGTGCAGAGAAGAAATATTGAAGGGTTTCACAGACCAGCTGCGTAAGATT TCTAAGGATGCAGGGATGCCCATCCAGGGCCAGCCATGCTTCTGCAAATAT GCACAGGGGGCAGACAGCGTAGAGCCCATGTTCCGGCATCTCAAGAACAC ATATTCTGGCCTACAGCTTATTATCGTCATCCTGCCGGGGAAGACACCAGTG TATGATAATTCCTACCAACAACCTTATGGGGAAAACGAGTACCCTCTAGTG AGATTCCTCCGCCAACCAATTTACATGGAAGTGAGAGTCCTAAACAGGGAT GACCCCAACATCAAGCTGGTCTTAGATGACTGCTGGGCGACGTCCACCATG GATCCAGACTCTTTCCCCCAGTGGAACGTTGTCGTGGATGGCTGTGCATATG ACCTGGACAACTACCAGACCACCTTCCATCCAGTCGGCTCCTCTGTGACCC ATCCTGATCACTATCAGAGGTTTGACATGAAGGCTTTTGCCTTTGTATCAGA AGCCCACGTGCTCTCTAGCCTGGTCTACTTCCACTGCAGTGCCTTAATCTGT AATCGACTCTCCCCTGACTCCCCACTGTGTTCTGTGACCTGCCCTGTGTCCT CTAGGCACAGGCGAGCCACAGGGGCCACTGAAGCAGAGAAAATGACAGTC AGCCTCCCAGGACCCATTCTCCTGTTGTCAGATGACTCCTCATTCAGAGGTG TCGGCTCATCTGATCTAAAAGCAAGTGGGAGCAGTGGGGAGAAGAGTAGG AGTGAAACAGGGGAGGAGGTTGGCTCACGAGGTGCTATGGACACCAAAGG GCACAAGACTGCTGGAGATGTTGGTTCCAAAGCTGTGGCTGCTGTGGCTGC CTTTGCAGGTGTGGTGGCAACTCTAGGCTTCATCTACTACCTGTACGAGAAA AGGACTGTGTCAAATCACTAA TPP2-> ATGGCCACCGCTGCGACTGAGGAGCCCTTCCCTTTTCACGGTCTCCTGCCGA SEQ ID B CA2 AGAAGGAGACCGGAGCCGCCTCCTTCCTCTGCCGCTACCCGGAGTATGATG NO: 12 GGCGGGGGGTGCTCATCGCAGTCCTGGACACGGGGGTCGACCCGGGGGCTC CGGGCATGCAGATGCCTATTGGATCCAAAGAGAGGCCAACATTTTTTGAAA TTTTTAAGACACGCTGCAACAAAGCAGATTTAGGACCAATAAGTCTTAATT GGTTTGAAGAACTTTCTTCAGAAGCTCCACCCTATAATTCTGAACCTGCAGA AGAATCTGAACATAAAAACAACAATTACGAACCAAACCTATTTAAAACTCC ACAAAGGAAACCATCTTATAATCAGCTGGCTTCAACTCCAATAATATTCAA AGAGCAAGGGCTGACTCTGCCGCTGTACCAATCTCCTGTAAAAGAATTAGA TAAATTCAAATTAGACTTAGGAAGGAATGTTCCCAATAGTAGACATAAAAG TCTTCGCACAGTGAAAACTAAAATGGATCAAGCAGATGATGTTTCCTGTCC ACTTCTAAATTCTTGTCTTAGTGAAAGTCCTGTTGTTCTACAATGTACACAT GTAACACCACAAAGAGATAAGTCAGTGGTATGTGGGAGTTTGTTTCATACA CCAAAGTTTGTGAAGGGTCGTCAGACACCAAAACATATTTCTGAAAGTCTA GGAGCTGAGGTGGATCCTGATATGTCTTGGTCAAGTTCTTTAGCTACACCAC CCACCCTTAGTTCTACTGTGCTCATAGTCAGAAATGAAGAAGCATCTGAAA CTGTATTTCCTCATGATACTACTGCTAATGTGAAAAGCTATTTTTCCAATCA TGATGAAAGTCTGAAGAAAAATGATAGATTTATCGCTTCTGTGACAGACAG TGAAAACACAAATCAAAGAGAAGCTGCAAGTCATGGATTTGGAAAAACAT CAGGGAATTCATTTAAAGTAAATAGCTGCAAAGACCACATTGGAAAGTCAA TGCCAAATGTCCTAGAAGATGAAGTATATGAAACAGTTGTAGATACCTCTG AAGAAGATAGTTTTTCATTATGTTTTTCTAAATGTAGAACAAAAAATCTACA AAAAGTAAGAACTAGCAAGACTAGGAAAAAAATTTTCCATGAAGCAAACG CTGATGAATGTGAAAAATCTAAAAACCAAGTGAAAGAAAAATACTCATTTG TATCTGAAGTGGAACCAAATGATACTGATCCATTAGATTCAAATGTAGCAA ATCAGAAGCCCTTTGAGAGTGGAAGTGACAAAATCTCCAAGGAAGTTGTAC CGTCTTTGGCCTGTGAATGGTCTCAACTAACCCTTTCAGGTCTAAATGGAGC CCAGATGGAGAAAATACCCCTATTGCATATTTCTTCATGTGACCAAAATATT TCAGAAAAAGACCTATTAGACACAGAGAACAAAAGAAAGAAAGATTTTCT TACTTCAGAGAATTCTTTGCCACGTATTTCTAGCCTACCAAAATCAGAGAAG CCATTAAATGAGGAAACAGTGGTAAATAAGAGAGATGAAGAGCAGCATCT TGAATCTCATACAGACTGCATTCTTGCAGTAAAGCAGGCAATATCTGGAAC TTCTCCAGTGGCTTCTTCATTTCAGGGTATCAAAAAGTCTATATTCAGAATA AGAGAATCACCTAAAGAGACTTTCAATGCAAGTTTTTCAGGTCATATGACT GATCCAAACTTTAAAAAAGAAACTGAAGCCTCTGAAAGTGGACTGGAAAT ACATACTGTTTGCTCACAGAAGGAGGACTCCTTATGTCCAAATTTAATTGAT AATGGAAGCTGGCCAGCCACCACCACACAGAATTCTGTAGCTTTGAAGAAT GCAGGTTTAATATCCACTTTGAAAAAGAAAACAAATAAGTTTATTTATGCT ATACATGATGAAACATCTTATAAAGGAAAAAAAATACCGAAAGACCAAAA ATCAGAACTAATTAACTGTTCAGCCCAGTTTGAAGCAAATGCTTTTGAAGC ACCACTTACATTTGCAAATGCTGATTCAGGTTTATTGCATTCTTCTGTGAAA AGAAGCTGTTCACAGAATGATTCTGAAGAACCAACTTTGTCCTTAACTAGC TCTTTTGGGACAATTCTGAGGAAATGTTCTAGAAATGAAACATGTTCTAATA ATACAGTAATCTCTCAGGATCTTGATTATAAAGAAGCAAAATGTAATAAGG AAAAACTACAGTTATTTATTACCCCAGAAGCTGATTCTCTGTCATGCCTGCA GGAAGGACAGTGTGAAAATGATCCAAAAAGCAAAAAAGTTTCAGATATAA AAGAAGAGGTCTTGGCTGCAGCATGTCACCCAGTACAACATTCAAAAGTGG AATACAGTGATACTGACTTTCAATCCCAGAAAAGTCTTTTATATGATCATGA AAATGCCAGCACTCTTATTTTAACTCCTACTTCCAAGGATGTTCTGTCAAAC CTAGTCATGATTTCTAGAGGCAAAGAATCATACAAAATGTCAGACAAGCTC AAAGGTAACAATTATGAATCTGATGTTGAATTAACCAAAAATATTCCCATG GAAAAGAATCAAGATGTATGTGCTTTAAATGAAAATTATAAAAACGTTGAG CTGTTGCCACCTGAAAAATACATGAGAGTAGCATCACCTTCAAGAAAGGTA CAATTCAACCAAAACACAAATCTAAGAGTAATCCAAAAAAATCAAGAAGA AACTACTTCAATTTCAAAAATAACTGTCAATCCAGACTCTGAAGAACTTTTC TCAGACAATGAGAATAATTTTGTCTTCCAAGTAGCTAATGAAAGGAATAAT CTTGCTTTAGGAAATACTAAGGAACTTCATGAAACAGACTTGACTTGTGTA AACGAACCCATTTTCAAGAACTCTACCATGGTTTTATATGGAGACACAGGT GATAAACAAGCAACCCAAGTGTCAATTAAAAAAGATTTGGTTTATGTTCTT GCAGAGGAGAACAAAAATAGTGTAAAGCAGCATATAAAAATGACTCTAGG TCAAGATTTAAAATCGGACATCTCCTTGAATATAGATAAAATACCAGAAAA AAATAATGATTACATGAACAAATGGGCAGGACTCTTAGGTCCAATTTCAAA TCACAGTTTTGGAGGTAGCTTCAGAACAGCTTCAAATAAGGAAATCAAGCT CTCTGAACATAACATTAAGAAGAGCAAAATGTTCTTCAAAGATATTGAAGA ACAATATCCTACTAGTTTAGCTTGTGTTGAAATTGTAAATACCTTGGCATTA GATAATCAAAAGAAACTGAGCAAGCCTCAGTCAATTAATACTGTATCTGCA CATTTACAGAGTAGTGTAGTTGTTTCTGATTGTAAAAATAGTCATATAACCC CTCAGATGTTATTTTCCAAGCAGGATTTTAATTCAAACCATAATTTAACACC TAGCCAAAAGGCAGAAATTACAGAACTTTCTACTATATTAGAAGAATCAGG AAGTCAGTTTGAATTTACTCAGTTTAGAAAACCAAGCTACATATTGCAGAA GAGTACATTTGAAGTGCCTGAAAACCAGATGACTATCTTAAAGACCACTTC TGAGGAATGCAGAGATGCTGATCTTCATGTCATAATGAATGCCCCATCGAT TGGTCAGGTAGACAGCAGCAAGCAATTTGAAGGTACAGTTGAAATTAAACG GAAGTTTGCTGGCCTGTTGAAAAATGACTGTAACAAAAGTGCTTCTGGTTA TTTAACAGATGAAAATGAAGTGGGGTTTAGGGGCTTTTATTCTGCTCATGGC ACAAAACTGAATGTTTCTACTGAAGCTCTGCAAAAAGCTGTGAAACTGTTT AGTGATATTGAGAATATTAGTGAGGAAACTTCTGCAGAGGTACATCCAATA AGTTTATCTTCAAGTAAATGTCATGATTCTGTTGTTTCAATGTTTAAGATAG AAAATCATAATGATAAAACTGTAAGTGAAAAAAATAATAAATGCCAACTG ATATTACAAAATAATATTGAAATGACTACTGGCACTTTTGTTGAAGAAATT ACTGAAAATTACAAGAGAAATACTGAAAATGAAGATAACAAATATACTGC TGCCAGTAGAAATTCTCATAACTTAGAATTTGATGGCAGTGATTCAAGTAA AAATGATACTGTTTGTATTCATAAAGATGAAACGGACTTGCTATTTACTGAT CAGCACAACATATGTCTTAAATTATCTGGCCAGTTTATGAAGGAGGGAAAC ACTCAGATTAAAGAAGATTTGTCAGATTTAACTTTTTTGGAAGTTGCGAAA GCTCAAGAAGCATGTCATGGTAATACTTCAAATAAAGAACAGTTAACTGCT ACTAAAACGGAGCAAAATATAAAAGATTTTGAGACTTCTGATACATTTTTT CAGACTGCAAGTGGGAAAAATATTAGTGTCGCCAAAGAGTCATTTAATAAA ATTGTAAATTTCTTTGATCAGAAACCAGAAGAATTGCATAACTTTTCCTTAA ATTCTGAATTACATTCTGACATAAGAAAGAACAAAATGGACATTCTAAGTT ATGAGGAAACAGACATAGTTAAACACAAAATACTGAAAGAAAGTGTCCCA GTTGGTACTGGAAATCAACTAGTGACCTTCCAGGGACAACCCGAACGTGAT GAAAAGATCAAAGAACCTACTCTATTGGGTTTTCATACAGCTAGCGGGAAA AAAGTTAAAATTGCAAAGGAATCTTTGGACAAAGTGAAAAACCTTTTTGAT GAAAAAGAGCAAGGTACTAGTGAAATCACCAGTTTTAGCCATCAATGGGCA AAGACCCTAAAGTACAGAGAGGCCTGTAAAGACCTTGAATTAGCATGTGAG ACCATTGAGATCACAGCTGCCCCAAAGTGTAAAGAAATGCAGAATTCTCTC AATAATGATAAAAACCTTGTTTCTATTGAGACTGTGGTGCCACCTAAGCTCT TAAGTGATAATTTATGTAGACAAACTGAAAATCTCAAAACATCAAAAAGTA TCTTTTTGAAAGTTAAAGTACATGAAAATGTAGAAAAAGAAACAGCAAAA AGTCCTGCAACTTGTTACACAAATCAGTCCCCTTATTCAGTCATTGAAAATT CAGCCTTAGCTTTTTACACAAGTTGTAGTAGAAAAACTTCTGTGAGTCAGAC TTCATTACTTGAAGCAAAAAAATGGCTTAGAGAAGGAATATTTGATGGTCA ACCAGAAAGAATAAATACTGCAGATTATGTAGGAAATTATTTGTATGAAAA TAATTCAAACAGTACTATAGCTGAAAATGACAAAAATCATCTCTCCGAAAA ACAAGATACTTATTTAAGTAACAGTAGCATGTCTAACAGCTATTCCTACCAT TCTGATGAGGTATATAATGATTCAGGATATCTCTCAAAAAATAAACTTGATT CTGGTATTGAGCCAGTATTGAAGAATGTTGAAGATCAAAAAAACACTAGTT TTTCCAAAGTAATATCCAATGTAAAAGATGCAAATGCATACCCACAAACTG TAAATGAAGATATTTGCGTTGAGGAACTTGTGACTAGCTCTTCACCCTGCAA AAATAAAAATGCAGCCATTAAATTGTCCATATCTAATAGTAATAATTTTGA GGTAGGGCCACCTGCATTTAGGATAGCCAGTGGTAAAATCGTTTGTGTTTC ACATGAAACAATTAAAAAAGTGAAAGACATATTTACAGACAGTTTCAGTAA AGTAATTAAGGAAAACAACGAGAATAAATCAAAAATTTGCCAAACGAAAA TTATGGCAGGTTGTTACGAGGCATTGGATGATTCAGAGGATATTCTTCATAA CTCTCTAGATAATGATGAATGTAGCACGCATTCACATAAGGTTTTTGCTGAC ATTCAGAGTGAAGAAATTTTACAACATAACCAAAATATGTCTGGATTGGAG AAAGTTTCTAAAATATCACCTTGTGATGTTAGTTTGGAAACTTCAGATATAT GTAAATGTAGTATAGGGAAGCTTCATAAGTCAGTCTCATCTGCAAATACTT GTGGGATTTTTAGCACAGCAAGTGGAAAATCTGTCCAGGTATCAGATGCTT CATTACAAAACGCAAGACAAGTGTTTTCTGAAATAGAAGATAGTACCAAGC AAGTCTTTTCCAAAGTATTGTTTAAAAGTAACGAACATTCAGACCAGCTCA CAAGAGAAGAAAATACTGCTATACGTACTCCAGAACATTTAATATCCCAAA AAGGCTTTTCATATAATGTGGTAAATTCATCTGCTTTCTCTGGATTTAGTAC AGCAAGTGGAAAGCAAGTTTCCATTTTAGAAAGTTCCTTACACAAAGTTAA GGGAGTGTTAGAGGAATTTGATTTAATCAGAACTGAGCATAGTCTTCACTA TTCACCTACGTCTAGACAAAATGTATCAAAAATACTTCCTCGTGTTGATAAG AGAAACCCAGAGCACTGTGTAAACTCAGAAATGGAAAAAACCTGCAGTAA AGAATTTAAATTATCAAATAACTTAAATGTTGAAGGTGGTTCTTCAGAAAA TAATCACTCTATTAAAGTTTCTCCATATCTCTCTCAATTTCAACAAGACAAA CAACAGTTGGTATTAGGAACCAAAGTGTCACTTGTTGAGAACATTCATGTTT TGGGAAAAGAACAGGCTTCACCTAAAAACGTAAAAATGGAAATTGGTAAA ACTGAAACTTTTTCTGATGTTCCTGTGAAAACAAATATAGAAGTTTGTTCTA CTTACTCCAAAGATTCAGAAAACTACTTTGAAACAGAAGCAGTAGAAATTG CTAAAGCTTTTATGGAAGATGATGAACTGACAGATTCTAAACTGCCAAGTC ATGCCACACATTCTCTTTTTACATGTCCCGAAAATGAGGAAATGGTTTTGTC AAATTCAAGAATTGGAAAAAGAAGAGGAGAGCCCCTTATCTTAGTGGGAG AACCCTCAATCAAAAGAAACTTATTAAATGAATTTGACAGGATAATAGAAA ATCAAGAAAAATCCTTAAAGGCTTCAAAAAGCACTCCAGATGGCACAATAA AAGATCGAAGATTGTTTATGCATCATGTTTCTTTAGAGCCGATTACCTGTGT ACCCTTTCGCACAACTAAGGAACGTCAAGAGATACAGAATCCAAATTTTAC CGCACCTGGTCAAGAATTTCTGTCTAAATCTCATTTGTATGAACATCTGACT TTGGAAAAATCTTCAAGCAATTTAGCAGTTTCAGGACATCCATTTTATCAAG TTTCTGCTACAAGAAATGAAAAAATGAGACACTTGATTACTACAGGCAGAC CAACCAAAGTCTTTGTTCCACCTTTTAAAACTAAATCACATTTTCACAGAGT TGAACAGTGTGTTAGGAATATTAACTTGGAGGAAAACAGACAAAAGCAAA ACATTGATGGACATGGCTCTGATGATAGTAAAAATAAGATTAATGACAATG AGATTCATCAGTTTAACAAAAACAACTCCAATCAAGCAGTAGCTGTAACTT TCACAAAGTGTGAAGAAGAACCTTTAGATTTAATTACAAGTCTTCAGAATG CCAGAGATATACAGGATATGCGAATTAAGAAGAAACAAAGGCAACGCGTC TTTCCACAGCCAGGCAGTCTGTATCTTGCAAAAACATCCACTCTGCCTCGAA TCTCTCTGAAAGCAGCAGTAGGAGGCCAAGTTCCCTCTGCGTGTTCTCATAA ACAGCTGTATACGTATGGCGTTTCTAAACATTGCATAAAAATTAACAGCAA AAATGCAGAGTCTTTTCAGTTTCACACTGAAGATTATTTTGGTAAGGAAAGT TTATGGACTGGAAAAGGAATACAGTTGGCTGATGGTGGATGGCTCATACCC TCCAATGATGGAAAGGCTGGAAAAGAAGAATTTTATAGGGCTCTGTGTGAC ACTCCAGGTGTGGATCCAAAGCTTATTTCTAGAATTTGGGTTTATAATCACT ATAGATGGATCATATGGAAACTGGCAGCTATGGAATGTGCCTTTCCTAAGG AATTTGCTAATAGATGCCTAAGCCCAGAAAGGGTGCTTCTTCAACTAAAAT ACAGATATGATACGGAAATTGATAGAAGCAGAAGATCGGCTATAAAAAAG ATAATGGAAAGGGATGACACAGCTGCAAAAACACTTGTTCTCTGTGTTTCT GACATAATTTCATTGAGCGCAAATATATCTGAAACTTCTAGCAATAAAACT AGTAGTGCAGATACCCAAAAAGTGGCCATTATTGAACTTACAGATGGGTGG TATGCTGTTAAGGCCCAGTTAGATCCTCCCCTCTTAGCTGTCTTAAAGAATG GCAGACTGACAGTTGGTCAGAAGATTATTCTTCATGGAGCAGAACTGGTGG GCTCTCCTGATGCCTGTACACCTCTTGAAGCCCCAGAATCTCTTATGTTAAA GATTTCTGCTAACAGTACTCGGCCTGCTCGCTGGTATACCAAACTTGGATTC TTTCCTGACCCTAGACCTTTTCCTCTGCCCTTATCATCGCTTTTCAGTGATGG AGGAAATGTTGGTTGTGTTGATGTAATTATTCAAAGAGCATACCCTATACA GTGGATGGAGAAGACATCATCTGGATTATACATATTTCGCAATGAAAGAGA GGAAGAAAAGGAAGCAGCAAAATATGTGGAGGCCCAACAAAAGAGACTA GAAGCCTTATTCACTAAAATTCAGGAGGAATTTGAAGAACATGAAGAAAAC ACAACAAAACCATATTTACCATCACGTGCACTAACAAGACAGCAAGTTCGT GCTTTGCAAGATGGTGCAGAGCTTTATGAAGCAGTGAAGAATGCAGCAGAC CCAGCTTACCTTGAGGGTTATTTCAGTGAAGAGCAGTTAAGAGCCTTGAAT AATCACAGGCAAATGTTGAATGATAAGAAACAAGCTCAGATCCAGTTGGA AATTAGGAAGGCCATGGAATCTGCTGAACAAAAGGAACAAGGTTTATCAA GGGATGTCACAACCGTGTGGAAGTTGCGTATTGTAAGCTATTCAAAAAAAG AAAAAGATTCAGTTATACTGAGTATTTGGCGTCCATCATCAGATTTATATTC TCTGTTAACAGAAGGAAAGAGATACAGAATTTATCATCTTGCAACTTCAAA ATCTAAAAGTAAATCTGAAAGAGCTAACATACAGTTAGCAGCGACAAAAA AAACTCAGTATCAACAACTACCGGTTTCAGATGAAATTTTATTTCAGATTTA CCAGCCACGGGAGCCCCTTCACTTCAGCAAATTTTTAGATCCAGACTTTCAG CCATCTTGTTCTGAGGTGGACCTAATAGGATTTGTCGTTTCTGTTGTGAAAA AAACAGGACTTGCCCCTTTCGTCTATTTGTCAGACGAATGTTACAATTTACT GGCAATAAAGTTTTGGATAGACCTTAATGAGGACATTATTAAGCCTCATAT GTTAATTGCTGCAAGCAACCTCCAGTGGCGACCAGAATCCAAATCAGGCCT TCTTACTTTATTTGCTGGAGATTTTTCTGTGTTTTCTGCTAGTCCAAAAGAGG GCCACTTTCAAGAGACATTCAACAAAATGAAAAATACTGTTGAGAATATTG ACATACTTTGCAATGAAGCAGAAAACAAGCTTATGCATATACTGCATGCAA ATGATCCCAAGTGGTCCACCCCAACTAAAGACTGTACTTCAGGGCCGTACA CTGCTCAAATCATTCCTGGTACAGGAAACAAGCTTCTGATGTCTTCTCCTAA TTGTGAGATATATTATCAAAGTCCTTTATCACTTTGTATGGCCAAAAGGAAG TCTGTTTCCACACCTGTCTCAGCCCAGATGACTTCAAAGTCTTGTAAAGGGG AGAAAGAGATTGATGACCAAAAGAACTGCAAAAAGAGAAGAGCCTTGGAT TTCTTGAGTAGACTGCCTTTACCTCCACCTGTTAGTCCCATTTGTACATTTGT TTCTCCGGCTGCACAGAAGGCATTTCAGCCACCAAGGAGTTGTGGCACCAA ATACGAAACACCCATAAAGAAAAAAGAACTGAATTCTCCTCAGATGACTCC ATTTAAAAAATTCAATGAAATTTCTCTTTTGGAAAGTAATTCAATAGCTGAC GAAGAACTTGCATTGATAAATACCCAAGCTCTTTTGTCTGGTTCAACAGGA GAAAAACAATTTATATCTGTCAGTGAATCCACTAGGACTGCTCCCACCAGT TCAGAAGATTATCTCAGACTGAAACGACGTTGTACTACATCTCTGATCAAA GAACAGGAGAGTTCCCAGGCCAGTACGGAAGAATGTGAGAAAAATAAGCA GGACACAATTACAACTAAAAAATATATCTAA CLEC16A ATGTTTGGCCGCTCGCGGAGCTGGGTGGGCGGGGGCCATGGCAAGACTTCC SEQ ID -> CGCAACATCCACTCCTTGGACCACCTCAAGTATCTGTACCACGTTTTGACCA NO: 13 BCA 4 AAAACACCACAGTCACAGAACAGAACCGGAACCTGCTAGTGGAGACCATC CGTTCCATCACTGAGATCCTGATCTGGGGAGATCAAAATGACAGCTCTGTA TTTGACTTCTTCCTGGAGAAGAATATGTTTGTTTTCTTCTTGAACATCTTGCG GCAAAAGTCGGGCCGTTACGTGTGCGTTCAGCTGCTGCAGACCTTGAACAT CCTCTTTGAGAACATCAGTCACGAGACCTCACTTTATTATTTGCTCTCAAAT AACTACGTAAATTCTATCATCGTTCATAAATTTGACTTTTCTGATGAGGAGA TTATGGCCTATTATATATCGTTCCTGAAAACACTTTCGTTAAAACTCAACAA CCACACTGTCCATTTCTTTTATAATGAGCACACCAATGACTTTGCCCTGTAC ACAGAAGCCATCAAGTTTTTCAACCACCCTGAAAGCATGGTTAGAATTGCT GTAAGAACCATAACTTTGAATGTCTATAAAGTCTCAGTGGATAACCAGGCC ATGCTGCACTACATCCGAGATAAAACTGCTGTTCCTTACTTCTCCAATTTGG TCTGGTTCATTGGGAGCCATGTGATCGAACTCGATGACTGCGTGCAGACTG ATGAGGAGCATCGGAATCGGGGTAAACTGAGTGATCTGGTGGCAGAGCAC CTAGACCACCTGCACTATCTCAATGACATCCTGATCATCAACTGTGAGTTCC TCAACGATGTGCTCACTGACCACCTGCTCAACAGGCTCTTCCTGCCCCTCTA CGTGTACTCACTGGAGAACCAGGACAAGGGAGGAGAACGGCCGAAAATTA GCCTGCCGGTGTCTCTTTATCTTCTGTCACAGGTCTTCTTAATTATACATCAT GCACCGCTGGTGAACTCGTTAGCTGAAGTCATTCTGAATGGTGATCTGTCTG AGATGTACGCTAAGACTGAACAGGATATTCAGAGAAGTTCTGCCAAGCCCA GCATTCGGTGCTTCATTAAACCCACCGAGACACTCGAGCGGTCCCTTGAGA TGAACAAGCACAAGGGCAAGAGGCGGGTGCAAAAGAGACCCAACTACAAA AACGTTGGGGAAGAAGAAGATGAGGAGAAAGGGCCCACCGAGGATGCCCA AGAAGACGCCGAGAAGGCTAAAGGTACAGAGGGTGGTTCAAAAGGCATCA AGACGAGTGGGGAGAGTGAAGAGATCGAGATGGTGATCATGGAGCGTAGC AAGCTCTCAGAGCTGGCCGCCAGCACCTCCGTGCAGGAGCAGAACACCAC GGACGAGGAGAAAAGCGCCGCCGCCACCTGCTCTGAGAGCACGCAATGGA GCAGACCCTTCCTGGATATGGTGTACCACGCGCTGGACAGCCCGGATGATG ATTACCATGCCCTGTTCGTGCTCTGCCTCCTCTATGCCATGTCTCATAATAA AGGCATGGATCCTGAAAAATTAGAGCGAATCCAGCTCCCCGTGCCAAATGC GGCCGAGAAGACCACCTACAACCACCCGCTAGCTGAAAGACTCATCAGGAT CATGAACAACGCTGCCCAGCCAGATGGGAAGATCCGGCTGGCGACGCTGG AGCTGAGCTGCCTGCTTCTGAAGCAGCAAGTCCTGATGAGTGCTGGCTGCA TCATGAAGGACGTGCACCTGGCCTGCCTGGAGGGTGCGAGAGAAGAAAGT GTTCACCTTGTACGACATTTTTATAAGGGAGAAGACATTTTTTTGGACATGT TTGAAGATGAGTATAGGAGCATGACAATGAAGCCCATGAACGTGGAATATC TCATGATGGACGCCTCCATCCTGCTGCCCCCAACAGGCACGCCACTGACGG GCATTGACTTCGTGAAGCGGCTGCCGTGTGGCGATGTGGAGAAGACCCGGC GGGCCATCCGGGTGTTCTTCATGCTGCGTTCCCTGTCACTGCAATTGCGAGG GGAGCCTGAGACACAGTTGCCGCTGACTCGGGAGGAGGACCTGATCAAGA CTGATGATGTCCTGGATCTGACAAAAAATCACCATGTACCAACCTATCCAA ACTTATCCATGGATGAATCTATCCAGAAGACGGGAGTTCCGATGCTTGTCTT GCTCTGAATGTCTGCTTGTCACCTGCTTAGGGTTATCGACTGTGATTCTGGG ACTCATTGTTGTTCTACAGGACCCCTCTGACTCTGTGGTTTTCTCTACTGGAT TAACAATGATAGCCATAGGTGCTTTTTTTGTTGTCCTCACTGGAGTGACAGC CCTGTGTACGGTTACAGTCGACGAGAACTTGCAGAAAACCACGAGGCTAAG ACTAGGAGTGATACGAAAAAGCGGAAGTCTCCAAGGAACTACAGAGCCTT CCATGACTCACTCAATAATCGCTAGCACCTCGCTGTAGTTGTACATTGAACC CTGGCATCTTCGTCTTTGGAACTAAGTCTCCTGAGCATTGTTTTTAAATAGA AATAAAATCTGGCTTTTAA ERBB2-> ATGGAGCTGGCGGCCTTGTGCCGCTGGGGGCTCCTCCTCGCCCTCTTGCCCC SEQ ID IKZF3 CCGGAGCCGCGAGCACCCAAGTGTGCACCGGCACAGACATGAAGCTGCGG NO: 14 CTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAG GGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAAT GCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTC ATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGCGGATTGTG CGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAAT GGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGC CTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTC TTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAG GACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGACACCAAC CGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCT GGGGAGAGAGTTCTGAGGATTGTCAGAGCCTGACGCGCACTGTCTGTGCCG GTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGACTGCTGCCATGAGC AGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGCCTGCC TCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCAC CTACAACACAGACACGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATAC ATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACCTTTCTACGGAC GTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCA GAGGATGGAACACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGT GTGCTATGGTCTGGGCATGGAGCACTTGCGAGAGGTGAGGGCAGTTACCAG TGCCAATATCCAGGAGTTTGCTGGCTGCAAGAAGATCTTTGGGAGCCTGGC ATTTCTGCCGGAGAGCTTTGATGGATGATTCAATGAAAGTGAAAGATGAAT ACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGGAAATGCA GAAGAGCCTGAAATCCCTTACAGCTATTCAAGAGAATATAATGAATATGAA AACATTAAGTTGGAGAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACC AGTGGAAAGATGAACTGCGATGTGTGTGGATTATCCTGCATCAGCTTCAAT GTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTCCAGTGT AATCAGTGTGGGGCATCTTTTACTCAGAAAGGTAACCTCCTCCGCCACATTA AACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACTATGCAT GCCAAAGAAGAGATGCGCTCACGGGGCATCTTAGGACACATTCTGTGGAGA AACCCTACAAATGTGAGTTTTGTGGAAGGAGTTACAAGCAGAGAAGTTCCC TTGAGGAGCACAAGGAGCGCTGCCGTACATTTCTTCAGAGCACTGACCCAG GGGACACTGCAAGTGCGGAGGCAAGACACATCAAAGCAGAGATGGGAAGT GAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAAAACGAAA AAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGCGCCACTGCTTTGATGT CAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGAC CCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGA AGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCTCGGAGATGGT TCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTC AAACGGTGCCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGA AGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACT CCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGC AAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGG AGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAG ACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGTATCGGT GTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACAT GGGCTGCCACGGCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCG AAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACAG AGCCCTGCTGAAGTGA TANC2-> ATGTTTCGGAATAGTCTCAAGATGCTGCTTACTGGTGGGAAATCAAGTCGT SEQ ID DM 1 AAAAACAGGTCAAGTGAAAGTGGTAAAATAGCTGTGGAGTACAGACCCAG NO: 15 TGAAGACATCGTAGGTGTCAGATGCGAAGAAGAACTACACGGTTTAATTCA AGTCCCTTGCTCTCCCTGGAAGCAGTATGGCCAAGAGGAGGAAGGGTATCT CTCGGATTTCAGCTTGGAGGAGGAAGAGTTCAGGCTGCCAGAACTTGACTA G PIK3C3-> ATGGGGGAAGCAGAGAAGTTTCACTACATCTATAGTTGTGACCTGGATATC SEQ ID RPRD1A AACGTCCAGCTTAAGATAGGAAGCTTGGAAGGGAAGAGAGAACAAAAGAG NO: 16 TTATAAAGCTGTCCTGGAAGACCCAATGTTGAAGTTCTCAGGACTATATCA AGAGACATGCTCTGATCTTTATGTTACTTGTCAAGTTTTTGCAGAAGGGAAG CCTTTGGCCTTGCCAGTGAGAACATCCTACAAAGCATTTAGTACAAGATGG AACTGGAATGAATGGCTGAAACTACCAGTAAAATACCCTGACCTGCCCAGG AATGCCCAAGTGGCCCTCACCATATGGGATGTGTATGGTCCCGGAAAAGCA GTGCCTGTAGGAGGAACAACGGTTTCGCTCTTTGGAAAATACGGCATGTTT CGCCAAGGGATGCATGACTTGAAAGTCTGGCCTAATGTAGAAGCAGATGGA TCAGAACCCACAAAAACTCCTGGCAGAACAAGTAGCACTCTCTCAGAAGAT CAGATGAGCCGTCTTGCCAAGCTCACCAAAGCTCATCGACAAGGACACATG GTGAAAGTAGATTGGCTGGATAGATTGACATTTAGAGAAATAGAAATGATA AATGAGAGTGAAAAACGAAGTTCTAATTTCATGTACCTGATGGTTGAATTT CGATGTGTCAAGTGTGATGATAAGGAATATGGTATTGTTTATTATGAAAAG GACGGTGATGAATCATCTCCAATTTTAACAAGTTTTGAATTAGTGAAAGTTC CTGACCCCCAGATGTCTATGGAGAATTTAGTTGAGAGCAAACACCACAAGC TTGCCCGGAGTTTAAGAAGTGGACCTTCTGACCACGATCTGAAACCCAATG CTGCCACGAGAGATCAGTTAAATATTATTGTGAGTTATCCACCAACCAAGC AACTTACATATGAAGAACAAGATCTTGTTTGGAAGTTTAGATATTATCTTAC GAATCAAGAAAAAGCCTTGACAAAATTCTTGAAATGTGTTAATTGGGATCT ACCTCAAGAGGCCAAACAGGCCTTGGAACTTCTGGGAAAATGGAAGCCGA TGGATGTAGAGGACTCCTTGGAGCTGTTATCCTCTCATTACACCAACCCAAC TGTGAGGCGTTATGCTGTTGCCCGGTTGCGACAGGCCGATGATGAGGATTT GTTGATGTACCTATTACAATTGGTCCAGGCTCTCAAATATGAAAATTTTGAT GATATAAAGAATGGATTGGAACCTACCAAGAAGGATAGTCAGAGTTCAGT GTCAGAAAATGTGTCAAATTCTGGAATAAATTCTGCAGAAATAGATAGCTC CCAAATTATAACCAGCCCCCTTCCTTCAGTCTCTTCACCTCCTCCTGCATCA AAAACAAAAGAAGTTCCAGATGGCGAAAATCTGGAACAAGATCTCTGTAC CTTCTTGATATCGAGAGCCTGCAAAAACTCAACACTGGCTAATTATTTATAC TGGTATGTGATAGTGGAATGTGAAGATCAAGATACTCAGCAGAGAGATCCA AAGACCCATGAGATGTACTTGAACGTAATGAGAAGATTCAGCCAAGCATTG TTGAAGGGTGATAAGTCTGTCAGAGTTATGCGTTCTTTGCTGGCTGCACAAC AGACATTTGTAGATCGGTTGGTGCATCTAATGAAGGCAGTACAACGCGAAA GTGGAAATCGTAAGAAAAAGAATGAGAGACTACAGGCATTGCTTGGAGAT AATGAAAAGATGAATTTGTCAGATGTGGAACTTATCCCGTTGCCTTTAGAA CCCCAAGTGAAAATTAGAGGAATAATTCCGGAAACAGCTACACTGTTTAAA AGTGCCCTTATGCCTGCACAGTTGTTTTTTAAGACGGAAGATGGAGGCAAA TATCCAGTTATATTTAAGCATGGAGATGATTTACGTCAAGATCAACTTATTC TTCAAATCATTTCACTCATGGACAAGCTGTTACGGAAAGAAAATCTGGACT TGAAATTGACACCTTATAAGGTGTTAGCCACCAGTACAAAACATGGCTTCA TGCAGTTTATCCAGTCAGTTCCTGTGGCTGAAGTTCTTGATACAGAGGGAA GCATTCAGAACTTTTTTAGAAAATATGCACCAAGTGAGAATGGGCCAAATG GGATTAGTGCTGAGGTCATGGACACTTACGTTAAAAGCTGTGCTGGATATT GCGTGATCACCTATATACTTGGAGTTGGAGACAGGCACCTGGATAACCTTT TGCTAACAAAAACAGCCAAACCAAACAGGAAGCTTACTTTTCTCTACCTAG CCAATGATGTCATACAGAACAGCAAGAGGAAGGGGCCAGAGTTTACAAAA GATTTTGCACCAGTTATAGTGGAGGCTTTTAAGCATGTTTCAAGTGAAACTG ATGAAAGTTGTAAGAAGCACCTTGGAAGAGTGTTATCTATTTGGGAAGAAA GGTCTGTTTATGAAAATGATGTATTAGAACAACTTAAACAAGCTCTGTATG GTGATAAGAAGCCTAGGAAGCGAACTTATGAACAGATAAAGGTGGATGAA AATGAAAACTGTTCCTCTCTGGGATCTCCAAGTGAACCACCACAGACTCTA GATCTCGTTAGAGCATTACAAGATCTGGAAAATGCAGCCTCAGGTGATGCA GCAGTTCATCAGAGGATAGCTTCTTTACCTGTTGAAGTCCAAGAAGTATCTC TATTAGATAAAATAACAGATAAAGAATCTGGAGAAAGGCTTTCCAAAATGG TAGAGGATGCGTGTATGTTGCTGGCAGATTACAATGGCAGATTGGCGGCAG AAATAGATGATAGAAAGCAACTCACTCGAATGTTAGCAGATTTTCTTCGTT GTCAAAAGGAAGCCCTTGCAGAGAAAGAGCATAAATTGGAAGAGTACAAG CGCAAGCTAGCCAGAGTTTCCCTGGTGCGCAAAGAACTCAGGTCCCGGATC CAGAGCCTGCCAGACTTATCTCGATTGCCCAATGTCACTGGCAGCCACATG CACCTGCCCTTTGCGGGAGACATCTACAGTGAAGATTGA PPP2R1A ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATA SEQ ID -> GACGAACTCCGCAATGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAG NO: 17 NLRP8 CTGTCCACCATCGCCTTGGCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTT CTGCCTTTCCTTACAGATACCATCTATGATGAAGATGAGGTCCTCCTGGCCC TGGCAGAACAGCTGGGAACCTTCACTACCCTGGTGGGAGGCCCAGAGTACG TGCACTGCCTGCTGAGCGCCAGAGAGCAATGGGCTGCATCGTTGGTGGCAA GACTTATGCTCTGTGTTTGCAACGAATGATAAGCTGGAAGTCCTGACTATG ACCAACAGTGTTTTGGGGCCTCCTTTTTTGAAGGCTCTCGCGGCCGCACTGA GGCACCCTCAGTGCAAACTGCAAAAGCTACTCCTAAGGCGTGTGAATAGCA CCATGTTGAACCAGGACTTAATCGGTGTTTTGACGGGGAACCAGCATCTGA GATACTTGGAAATACAACATGTGGAAGTGGAGTCCAAAGCTGTGAAGCTTC TATGCAGGGTGCTGAGATCCCCCCGGTGCCGTCTGCAGTGTCTCAGGTTGG AAGACTGCTTGGCCACCCCTAGAATTTGGACTGATCTTGGCAATAATCTTCA AGGTAACGGGCATCTAAAGACTCTCATACTAAGAAAAAACTCCCTGGAGAA CTGTGGGGCGTATTACCTGTCTGTGGCCCAGCTGGAGAGGCTGTCGATAGA GAACTGCAACCTTACACAGCTTACTTGTGAAAGCCTTGCCTCCTGTCTCAGG CAGAGTAAGATGCTGACCCACCTGAGCTTGGCAGAAAACGCCTTGAAAGAT GAAGGGGCCAAGCATATTTGGAATGCCCTGCCACACCTGAGATGTCCTCTG CAGAGGCTGGTACTGAGAAAGTGTGACTTGACCTTTAATTGCTGTCAGGAT ATGATCTCTGCGCTCTGTAAAAATAAAACCCTGAAAAGTCTTGACCTAAGT TTTAATAGCCTGAAGGATGATGGGGTGATCCTGCTGTGTGAGGCCCTGAAG AACCCTGACTGTACATTACAGATCCTGGAGCTGGAAAACTGCCTGTTCACC TCCATCTGCTGCCAGGCCATGGCTTCCATGCTCCGCAAAAACCAACATCTG AGACATCTGGACTTGAGCAAGAATGCGATTGGAGTCTATGGTATTCTGACC TTGTGCGAGGCCTTCTCAAGCCAAAAGAAGAGAGAAGAGGTCATTTTCTGT ATTCCTGCCTGGACTCGAATAACTAGCTTCTCCCCAACTCCTCACCCACCCG ACTTCACGGGAAAAAGTGACTGCCTATCCCAGATTAATCCTTAG RPS28-> ATGGACACCAGCCGTGTGCAGCCTATCAAGCTGGCCAGGGTCACCAAGGTC SEQ ID LOCI 005 CTGGGCAGGACCGGTTCTCAGGGACAGTGCACGCAGGGTTCTTCTGCTCAC NO: 18 05619 TGGGTCAGAAGCATCCGATTTCCTGTCATCGGTTGCGGTTCAGCCATGTTAA TACTGAAAGTATAAGAATATCATAATCCCAGAGTGATATAAAGACCTTTCC AAGGAAGATGAGATACCCGGAGGCTGTGAAGGAGAAGTCTGAAGGATTTG AACGCGTTCAAATGAAAACCTTTGGTTCAGCAAAACACCAGAAACAAATTC AAAAGATAAAATACACTCCGGAGAAGCCCATTCTCTCAACGCATCTGACAG TTCACAAAGAGCAACTGCAGTCCAACTTAAAAAATAAAGAAAATGGTAGG AAAATGGGCAACATGCACTGAGGCAATATATAAGAAGAAGGAATGCGCAA TTAATCAACAAAAGCCTGCTCTTTCCTAACGAGTGAAGATACAAGCTTAGT AAATATTAAAATTTATTGAAGATAAAAATGGACACTTCCGGCCATATATAA AAGCATTGTTGGTAAGAGAGTGGGGTAATTGACATGCTCCTGGGAAATAAT ACGCATTCAGACAACCTCTAATGAGTGAATCCACTGGGGGTATCCACTAGG AATAGAAAACGACCACCAATGCCCAAGTTTGTGGTCCAGAATTTGAGCAGC GATCTAACAAAGTAGAGTCTCCCCCTGTGTCATGGGCCCCACTTCTTAAGCA AAGAAGAATGCCTCATTTTGGTAACTCACCCAAATAAACAGAAATTTTTTTT GATAATCTTATCGCATTTATTTGGTTAAGTCTGAGGCAGAATATTTTTCTCC TTTGTATCTTTGTTTTGTTTTGTTTTAATCCTTGAAGTTTATTACCAAACTAC ATCTTGGTGTTTCTTCAGGATGTGAACAGGCCTTTCTATTCTCAATTAAGTG TTTCTTTCCTTTAATTCAGGAATCTTCTAATCATGTATTTTAATTTCTTTTTCT GTCATCCCTCCCCACGCCATAAGCTACCAGTCACTATACATGTTGGAGCTCT CTTTATTGTGCCATAGATCTCTGATGTCATGTCTTTAGTCATTATTTTGTGTC AGAAATTTTTGTTCTTCCGGGGACATCTGGCAATATCTAGAGACATGCTACT GGCACCTATAGAAATGCTAGTGACTTATTATGGGTAGAGGCTAAAGATGCT GCTAAATATCCTACAATGCCCAGGACAGCCACTGCCACAACAAAGAATTAT GCAGTCCACAATGTCCATAGTGCTAAGGAGAAGAAACCCTGTCCTAGGGTC AAGGTTGGATGCTGACAAGACTAATTTCAAGTGATTTCAAACGATTGTGGG GAAAATACCCAGAAGTTGACAGGAGCAATATGTAGATATTTCCTTCTGTAA ATTATATTTCCCTAATGCTAATGCTGGAGCATTTGGAAACACGTGTATAAAT ATTTGAAGCACAAAACCAGAGAGATGCTCTTATGTATTTAGCTTCTAGTTTT AAATAATAGATACTACAATAAACCTTGATTAAACCTTGATTATCTG NFYA-> GAACGGTCACTGCGCAGGATCAAGCTACAATGAAGAGGAGGGAGGCAGTC SEQ ID TD G1 TGCGCGCACCGCCATTTTCTAGGAACTGGGAAGCCCCCCCACCCCTTAGGA NO: 19 AGATCCATCCCTGTGGAACCTTGCCCAGGCTTACCAGCCTTTGCTGAGGTTG ATCTATTGTCCCTCCTTGTCCCCATCAAAATATCCAGCACTCCACCTTCAGG GAGTAGACTTGACCCTCAAATAGCAAGTTCAGCCTTCCCAGGTCTAGGTTC CCTGGGAGGTCAAGATTCGTCTGGTTCCTTAGTACAGAGGGCTAGCTGTGA GTTGGAATCCCCCTATGAGCTTTAGAATCAGTCAAGAGGAATTGGGCCCCT TCCCTTCATCCCTCTTCTTTTCCCTTTTTGTCCCAGAGCTCAGCTCTGACTCA AAAGTTTTTCCATTTACCATCAACATGGAAACTTGGCTCCTCACGTAGGTAT ATTATCCCCCTTTTGTACATGGTCTTGTTGATCCAAACTCCCTTTCTGTGAAA GAGGCCTGTGGGGCTCAAGAAGCCTGGTCAGCCAGCCAGGCTAGTCCCACA TACCTCAGAACCAGTTTAATAAAGGCTCTATGTCATTCTTTTTTG RIMS2-> ATGTCGGCTCCTGTCGGGCCCCGGGGCCGCCTGGCTCCCATCCCGGCGGCC SEQ ID DPYS TCTCAGCCGCCTCTGCAGCCCGAGATGCCTGACCTCAGCCACCTCACGGAG NO:20 GAGGAGAGGAAAATCATCCTGGCCGTCATGGATAGGCAGAAGAAAGAAGA GGAGAAGGAGCAGTCCGTGCTCAAAAAACTGCATCAGCAGTTTGAAATGTA TAAAGAGCAGGTAAAGAAGATGGGAGAAGAATCACAGCAACAGCAAGAA CAGAAGGGTGATGCGCCAACCTGTGGTATCTGCCACAAAACAAAGTTTGCT GATGGATGTGGCCATAACTGTTCATATTGCCAAACAAAGTTCTGTGCTCGTT GTGGAGGTCGAGTGTCATTACGCTCAAACAAGCATAGTGGTAAAATGGATG AAAACAGATTTGTGGCAGTTACCAGCACAAATGCAGCCAAAATTTTTAATC TCTATCCAAGAAAAGGAAGAATAGCTGTAGGATCAGATGCTGACATTGTTA TTTGGGACCCAAAAGGCACAAGGACTATCTCAGCAAAAACTCATCATCAGG CTGTTAACTTCAACATTTTCGAGGGCATGGTTTGCCACGGGGTGCCCCTTGT GACTATTTCAAGAGGCAAAGTGGTATATGAAGCCGGAGTGTTCAGTGTCAC GGCAGGAGATGGGAAGTTTATTCCTCGAAAACCATTTGCTGAATATATTTA CAAACGAATAAAGCAGCGAGACCGGACTTGCACACCTACCCCTGTGGAGC GTGCACCCTATAAGGGAGAAGTCGCCACACTGAAATCCAGAGTGACAAAA GAAGATGCCACAGCAGGGACCAGGAAACAGGCCCACCCCTGA B3GALN ATGCGAAACTGGCTGGTGCTGCTGTGCCCGTGTGTGCTCGGGGCCGCGCTG SEQ ID T2-> CACCTCTGGCTGCGGCTGCGCTCCCCGCCGCCCGCCTGCGCCTCCGGGGCC NO:21 TOMM20 GGCCCTGCAGATCAGTTGGCCTTATTTCCTCAGTGGAAATCTACTCACTATG ATGTGGTAGTTGGCGTGTTGTCAGCTCGCAATAACCATGAACTTCGAAACG TGATAAGAAGCACCTGGATGAGACATTTGCTACAGCATCCCACATTAAGTC AACGTGTGCTTGTGAAGTTCATAATAGGTGCTCATGGCTGTGAAGTGCCTGT GGAAGACAGGGAAGATCCTTATTCCTGTAAACTACTCAACATCACAAATCC AGTTTTGAATCAGGAAATTGAAGCGTTCAGTCTGTCCGAAGACACTTCATC GGGGCTGCCTGAGGATCGAGTTGTCAGCGTGAGTTTCCGAGTTCTCTACCCC ATCGTTATTACCAGTCTTGGAGTGTTCTACGATGCCAATGATGTGGGTTTCC AGAGGAACATCACTGTCAAACTTTATCAGGCAGAACAAGAGGAGGCCCTCT TCATTGCTCGCTTCAGTCCTCCAAGCTGTGGTGTGCAGGTGAACAAGCTGTG GTACAAGCCCGTGGAACAATTCATCTTACCAGAGAGCTTTGAAGGTACAAT CGTGTGGGAGAGCCAAGACCTCCACGGCCTTGTGTCAAGAAATCTCCACAA AGTGACAGTGAATGATGGAGGGGGAGTTCTCAGAGTCATTACAGCTGGGG AGGGTGCATTGCCTCATGAATTCTTGGAAGGTGTGGAGGGAGTTGCAGGTG GTTTTATATATACTATTCAGGGTGAATATGAGAAGGGCGTAGACCATCTGA CAAATGCAATTGCTGTGTGTGGACAGCCACAGCAGTTACTGCAGGTCTTAC AGCAAACTCTTCCACCACCAGTGTTCCAGATGCTTCTGACTAAGCTCCCAAC AATTAGTCAGAGAATTGTAAGTGCTCAGAGCTTGGCTGAAGATGATGTGGA ATGA Clorfl09- ATGACTCAAGACCGGCCTCTGCTTGCCGTGCAGGAGGCGCTGAAGAAGTGC SEQ ID > TTCCCCGTGGTGGAGGAGCAGCAGGGCCTGTGGCAGAGTGCCCTGCGGGAC NO:22 MACF1 TGCCAGCCCCTCCTGTCCTCCCTCAGCAACCTGGCGGAACAGCTGCAGGCC GCACAGAACCTGCGGTTTGAGGATGTGCCGGCGCTTCGGGCCTTCCCAGAT TTAAAAGAGCGGCTGAGGCGTAAGCAGCTGGTGGCTGGTGACATCGTCCTG GACAAGCTAGGGGAAAGGCTGCTCTCAGAAAAAGAGAAGAAACAAATATC TGAGCAATTGAATGCCCTAAACAAGGCTTACCATGACCTTTGTGATGGTTCT GCAAATCAGCTTCAGCAGCTTCAGAGCCAGTTGGCTCACCAGACAGAACAA AAGACCCTGCAGAAACAACAAAATACCTGTCACCAGCAACTGGAGGATCTT TGCAGTTGGGTAGGACAGGCAGAAAGAGCACTGGCAGGCCACCAAGGCAG AACCACCCAGCAGGATCTCTCTGCTTTGCAGAAGAACCAAAGTGACTTGAA GGATTTACAGGATGACATTCAGAATCGTGCCACCTCATTTGCCACTGTTGTC AAGGACATTGAGGGGTTCATGGAAGAGAATCAGACCAAGCTGAGCCCACG TGAGTTGACAGCTCTTCGGGAAAAGCTTCATCAGGCTAAGGAGCAATATGA GGCGCTCCAGGAAGAGACACGTGTGGCCCAGAAGGAACTGGAGGAAGCAG TGACCTCCGCCTTACAGCAGGAGACTGAAAAGAGTAAAGCAGCAAAGGAA CTGGCAGAGAACAAGAAGAAGATCGATGCTCTCCTGGATTGGGTAACTTCA GTAGGATCATCTGGTGGACAGCTGCTGACCAACCTTCCAGGAATGGAGCAG CTCTCGGGAGCTAGCTTGGAGAAAGGAGCCTTGGACACCACTGATGGTTAC ATGGGGGTGAATCAAGCCCCAGAGAAACTGGACAAGCAATGTGAGATGAT GAAGGCCCGTCACCAAGAATTGCTGTCCCAGCAGCAAAATTTCATTCTGGC CACCCAGTCAGCTCAGGCCTTCTTGGATCAGCATGGCCACAATCTCACACCT GAGGAGCAACAGATGCTGCAACAGAAGCTGGGAGAGCTAAAGGAACAATA CTCTACTTCCCTGGCCCAATCAGAGGCAGAACTGAAGCAGGTGCAGACACT TCAGGATGAGTTGCAGAAATTTCTGCAGGATCATAAAGAGTTTGAAAGCTG GTTGGAACGATCCGAGAAAGAGCTGGAGAACATGCATAAGGGAGGCAGCA GCCCCGAGACCCTTCCCTCCCTGCTAAAGCGGCAAGGAAGCTTCTCAGAGG ATGTCATTTCCCACAAAGGAGACTTGAGATTTGTGACTATCTCAGGACAGA AAGTCTTGGACATGGAAAACAGTTTTAAGGAAGGCAAAGAACCATCAGAA ATTGGAAACTTAGTAAAGGACAAGTTGAAGGATGCAACAGAAAGATACAC TGCTCTCCACTCAAAGTGTACACGATTAGGATCTCACCTGAATATGCTGTTA GGCCAGTATCATCAATTCCAAAACAGTGCTGACAGCCTGCAGGCCTGGATG CAGGCTTGTGAGGCCAACGTGGAGAAGCTCCTCTCAGATACTGTTGCCTCT GACCCTGGAGTTCTCCAGGAGCAGCTTGCAACAACAAAGCAGTTGCAGGAG GAATTGGCTGAGCACCAAGTACCTGTGGAAAAACTCCAAAAAGTAGCTCGT GACATAATGGAAATTGAAGGGGAGCCAGCCCCAGACCACAGGCATGTTCA AGAAACTACAGATTCCATACTCAGCCACTTCCAAAGCCTCTCCTATAGCCTG GCTGAGCGATCTTCTCTGCTGCAGAAAGCAATTGCCCAATCTCAGAGTGTC CAGGAAAGCCTGGAGAGCCTGTTGCAGTCTATTGGGGAAGTTGAACAAAAC CTGGAAGGGAAGCAGGTGTCATCACTCTCATCAGGAGTCATCCAGGAAGCC TTAGCCACAAATATGAAATTGAAGCAGGACATTGCTCGGCAAAAGAGCAG CTTGGAGGCCACCCGTGAGATGGTGACCCGATTCATGGAGACAGCAGACAG TACTACAGCAGCAGTGCTGCAGGGCAAACTGGCAGAGGTGAGCCAGCGGT TCGAACAGCTCTGTCTACAGCAGCAAGAAAAGGAGAGCTCCCTAAAGAAG CTTCTACCCCAGGCAGAGATGTTTGAACACCTCTCTGGTAAGCTGCAGCAG TTCATGGAAAACAAAAGTCGGATGCTGGCCTCTGGAAATCAGCCAGATCAA GATATTACACATTTCTTCCAACAGATCCAGGAGCTCAATTTGGAAATGGAA GACCAACAGGAGAACCTAGATACTCTTGAGCACCTGGTCACTGAACTGAGC TCTTGTGGCTTTGCGCTGGACTTGTGCCAGCATCAGGACAGGGTACAGAAT CTAAGAAAAGACTTCACAGAGCTACAGAAGACAGTTAAAGAGAGAGAGAA AGATGCATCATCTTGCCAGGAACAGTTGGATGAATTCCGGAAGCTGGTCAG GACCTTCCAGAAATGGTTGAAAGAAACTGAAGGGAGTATTCCACCTACGGA AACTTCTATGAGTGCTAAAGAGTTAGAAAAGCAGATTGAACACCTGAAGAG TCTACTAGATGACTGGGCAAGTAAGGGAACTCTGGTGGAAGAAATCAATTG CAAAGGTACTTCTTTAGAAAATCTCATCATGGAAATCACAGCACCTGATTC CCAAGGCAAGACAGGTTCCATACTGCCCTCTGTAGGAAGCTCTGTAGGCAG TGTAAACGGATACCACACCTGCAAAGATCTGACGGAGATCCAGTGTGACAT GTCAGATGTAAACTTGAAGTATGAGAAACTAGGGGGAGTACTTCATGAACG CCAGGAAAGCCTTCAGGCTATCCTCAACAGAATGGAGGAGGTTCACAAGG AGGCAAACTCTGTGCTGCAGTGGCTGGAATCAAAAGAGGAAGTCCTGAAAT CCATGGATGCCATGTCATCTCCAACCAAGACAGAAACAGTGAAAGCCCAAG CTGAATCTAACAAGGCCTTCCTGGCTGAGTTGGAACAGAATTCTCCAAAAA TTCAAAAAGTAAAGGAAGCCCTGGCTGGATTACTGGTGACATATCCCAACT CACAGGAAGCAGAAAATTGGAAGAAAATTCAGGAAGAACTCAATTCCCGA TGGGAAAGGGCCACTGAGGTTACTGTGGCTCGGCAAAGGCAGCTAGAGGA ATCTGCAAGTCATCTGGCCTGCTTCCAGGCTGCAGAATCCCAGCTCCGGCC GTGGCTGATGGAGAAAGAACTGATGATGGGAGTGCTGGGGCCCCTGTCTAT TGACCCCAACATGTTGAATGCACAAAAGCAACAGGTCCAGTTTATGCTAAA GGAATTTGAAGCACGCAGGCAACAGCATGAGCAACTGAATGAGGCAGCTC AGGGCATCCTAACAGGCCCTGGAGATGTCTCTCTGTCCACCAGCCAAGTAC AGAAAGAACTCCAGAGCATCAATCAGAAATGGGTTGAGCTGACTGACAAA CTCAACTCCCGTTCCAGCCAAATTGACCAAGCTATTGTTAAGAGCACCCAG TACCAGGAACTGCTCCAGGACTTATCAGAGAAGGTGAGGGCAGTTGGACA ACGGCTGAGTGTCCAGTCAGCTATCAGCACCCAACCAGAGGCTGTAAAGCA GCAATTGGAAGAGACCAGTGAAATTCGATCTGACTTGGAGCAGTTAGACCA CGAGGTTAAGGAGGCTCAGACACTGTGCGATGAACTCTCAGTGCTCATTGG TGAGCAGTACCTCAAGGATGAACTGAAGAAGCGTTTGGAGACAGTTGCCCT GCCTCTCCAAGGTTTAGAAGACCTTGCAGCCGATCGCATTAACAGACTCCA GGCAGCTCTTGCCAGCACCCAGCAGTTCCAGCAAATGTTTGATGAGTTGAG GACCTGGTTGGATGATAAACAAAGCCAGCAAGCAAAAAACTGCCCAATTTC TGCAAAATTGGAGCGGCTACAGTCTCAGCTACAGGAGAATGAAGAGTTTCA GAAAAGTCTTAATCAACACAGTGGCTCCTATGAGGTGATTGTGGCTGAAGG GGAATCTCTACTTCTTTCTGTACCTCCTGGAGAAGAGAAAAGGACTCTACA AAACCAGTTGGTTGAGCTCAAAAACCATTGGGAAGAGCTTAGTAAAAAAA CTGCAGACAGACAATCCAGGCTCAAGGATTGTATGCAGAAAGCTCAGAAAT ATCAGTGGCATGTGGAAGACCTTGTGCCATGGATAGAAGATTGTAAAGCTA AGATGTCTGAGTTGCGAGTCACTCTGGATCCAGTGCAGCTAGAGTCCAGTC TCCTAAGATCAAAGGCTATGCTGAATGAGGTGGAGAAGCGCCGCTCCCTGC TGGAAATATTGAATAGTGCTGCTGACATTCTGATCAATTCTTCAGAAGCAG ATGAGGATGGAATCCGGGATGAGAAGGCTGGGATCAACCAGAACATGGAT GCTGTTACAGAAGAGCTGCAGGCCAAAACAGGGTCACTCGAAGAAATGAC TCAGAGGCTCAGGGAGTTCCAGGAAAGCTTTAAGAATATTGAAAAGAAGG TTGAAGGAGCCAAACACCAACTTGAGATCTTTGATGCTCTGGGTTCTCAAG CCTGTAGCAACAAGAACCTGGAGAAGCTAAGAGCTCAACAGGAAGTGCTG CAGGCCCTAGAGCCTCAGGTAGACTATCTGAGGAACTTTACTCAGGGTCTG GTAGAAGATGCCCCAGATGGATCTGATGCTTCTCAACTTCTCCACCAAGCT GAGGTCGCCCAGCAAGAGTTCCTCGAAGTTAAGCAAAGAGTGAACAGTGG TTGTGTGATGATGGAAAACAAGCTGGAGGGGATTGGCCAGTTTCACTGCCG GGTCCGAGAGATGTTCTCTCAATTGGCAGACCTGGATGATGAGCTAGATGG CATGGGTGCTATTGGCAGAGACACTGATAGCCTCCAGTCCCAAATCGAGGA TGTCCGGCTATTCCTTAACAAAATTCACGTCCTCAAATTAGACATAGAGGCC TCTGAAGCAGAGTGTCGACATATGCTAGAAGAAGAGGGGACTCTGGATTTG TTAGGTCTCAAAAGGGAGCTAGAAGCCCTGAACAAACAGTGTGGCAAACT GACAGAGAGGGGGAAAGCTCGTCAGGAACAGCTGGAACTGACACTAGGCC GTGTAGAGGACTTCTACAGGAAATTGAAAGGACTCAATGACGCGACCACA GCAGCAGAGGAGGCAGAGGCCCTCCAGTGGGTAGTGGGGACCGAAGTGGA AATCATCAACCAACAATTAGCAGATTTTAAAATGTTTCAGAAAGAACAAGT GGATCCTCTTCAGATGAAATTGCAGCAGGTGAATGGACTTGGCCAGGGATT AATTCAGAGTGCAGGAAAAGACTGTGATGTACAGGGTTTAGAACATGACAT GGAAGAGATCAATGCTCGATGGAATACATTGAATAAAAAGGTCGCACAAA GAATTGCACAGCTACAGGAAGCTTTGTTGCATTGTGGGAAGTTTCAAGATG CCTTGGAGCCATTGCTCAGCTGGTTGGCAGATACCGAGGAGCTCATAGCCA ATCAGAAACCTCCATCTGCTGAGTATAAAGTGGTGAAAGCACAGATCCAAG AACAGAAGTTGCTCCAGCGGCTCCTAGATGATCGAAAGGCCACAGTAGACA TGCTTCAAGCAGAAGGAGGCAGAATAGCCCAGTCAGCAGAGCTGGCTGAT AGAGAGAAAATCACTGGACAGCTGGAGAGTCTTGAAAGTAGATGGACTGA ACTACTCAGTAAGGCAGCAGCCAGGCAAAAACAGCTGGAAGACATCCTGG TTCTGGCCAAACAGTTCCATGAGACAGCTGAGCCTATTTCTGACTTCTTATC TGTCACAGAGAAAAAGCTTGCTAACTCAGAACCTGTTGGCACTCAGACTGC CAAAATACAGCAGCAGATCATTCGGCACAAGGCTCTGGAAGAAGACATAG AAAACCATGCAACAGATGTGCACCAGGCAGTCAAAATTGGGCAGTCCCTCT CCTCCCTGACATCTCCTGCAGAACAGGGTGTGCTGTCAGAAAAGATAGACT CATTGCAGGCCCGATACAGTGAAATTCAAGACCGCTGTTGTCGGAAGGCAG CCCTACTTGACCAAGCTCTGTCTAATGCTAGGCTGTTTGGGGAGGATGAGG TGGAGGTGCTCAACTGGCTGGCTGAGGTTGAGGACAAGCTCAGTTCAGTGT TCGTAAAGGATTTCAAACAGGATGTCCTGCACAGGCAGCATGCTGACCACC TGGCTTTAAATGAAGAAATTGTTAATAGAAAGAAGAATGTAGATCAAGCTA TTAAAAATGGTCAGGCTCTTCTAAAACAAACCACAGGTGAGGAGGTGTTAC TTATCCAGGAAAAACTAGATGGTATAAAGACTCGTTACGCAGACATCACAG TTACTAGCTCCAAGGCCCTCAGAACTTTAGAGCAAGCCCGGCAGCTGGCCA CCAAGTTCCAGTCTACTTATGAGGAACTGACCGGGTGGCTGAGGGAGGTGG AGGAGGAGCTGGCAACCAGTGGAGGACAGTCTCCCACAGGGGAACAGATA CCCCAGTTTCAGCAGAGACAGAAGGAATTAAAGAAGGAGGTCATGGAGCA CAGGCTGGTGTTGGACACAGTGAATGAGGTGAGCCGTGCTCTCTTAGAGCT GGTGCCCTGGAGAGCCAGAGAAGGGCTGGATAAACTTGTGTCCGATGCTAA CGAGCAGTACAAACTAGTCAGTGACACTATTGGACAAAGGGTGGATGAAA TTGATGCTGCTATTCAGAGATCACAACAGTATGAGCAAGCTGCCGATGCAG AACTAGCTTGGGTTGCTGAAACAAAACGGAAACTGATGGCTCTGGGTCCAA TTCGCCTGGAACAGGACCAGACCACAGCTCAGCTTCAGGTACAGAAGGCTT TCTCCATTGACATTATTCGACACAAAGATTCAATGGATGAACTCTTCAGTCA CCGTAGTGAAATCTTTGGCACATGTGGGGAGGAGCAAAAAACTGTATTACA GGAAAAGACAGAGTCTCTAATACAGCAATATGAAGCCATTAGCCTACTCAA TTCAGAGCGTTATGCCCGCCTAGAGCGGGCCCAGGTCTTAGTAAACCAGTT TTGGGAAACTTATGAAGAGCTCAGCCCCTGGATTGAGGAAACTCGGGCACT AATAGCACAGTTACCCTCTCCAGCCATTGATCATGAGCAGCTCAGGCAGCA ACAAGAGGAAATGAGGCAATTAAGGGAATCTATTGCTGAACACAAACCTC ATATTGACAAACTACTAAAGATAGGCCCACAACTAAAGGAATTAAACCCTG AGGAAGGGGAAATGGTGGAAGAAAAATACCAGAAAGCAGAAAACATGTAT GCCCAAATAAAGGAGGAGGTGCGCCAGCGAGCCCTGGCTCTGGATGAAGC CGTGTCCCAGTCCACACAGATTACAGAGTTTCATGATAAAATTGAGCCTAT GTTGGAGACACTGGAGAATCTTTCCTCTCGCCTGCGTATGCCACCACTGATC CCTGCTGAAGTAGACAAGATCAGAGAGTGCATCAGTGACAATAAGAGTGC CACCGTGGAGCTAGAAAAACTGCAGCCATCCTTTGAGGCCTTGAAGCGCCG TGGAGAGGAGCTTATTGGACGATCTCAGGGAGCAGACAAGGATCTGGCTGC AAAAGAAATCCAGGATAAATTGGATCAAATGGTATTCTTCTGGGAGGACAT CAAAGCTCGGGCTGAAGAACGAGAAATCAAATTTCTTGATGTCCTTGAATT AGCAGAGAAGTTCTGGTATGACATGGCAGCTCTCCTGACCACCATCAAAGA CACCCAGGATATTGTCCATGACTTGGAAAGCCCAGGCATTGATCCTTCCATC ATCAAACAACAGGTTGAAGCTGCTGAGACTATTAAGGAAGAGACAGATGG TCTGCATGAAGAGCTGGAGTTTATTCGGATCCTTGGAGCAGATTTGATTTTT GCCTGTGGAGAAACTGAGAAGCCTGAAGTGAGGAAGAGCATTGATGAGAT GAATAATGCTTGGGAGAACTTAAACAAAACATGGAAAGAGAGGCTAGAAA AACTTGAGGATGCTATGCAAGCTGCTGTGCAGTATCAGGACACTCTTCAGG CTATGTTTGACTGGCTAGATAACACTGTGATTAAACTCTGCACCATGCCCCC TGTTGGCACTGACCTCAATACTGTTAAAGATCAGTTAAATGAAATGAAGGA GTTCAAAGTAGAAGTTTACCAACAGCAAATTGAGATGGAGAAGCTTAATCA CCAGGGTGAACTGATGTTAAAGAAAGCTACTGATGAGACGGACAGAGACA TTATACGAGAACCACTGACAGAACTCAAACACCTCTGGGAGAACCTGGGTG AGAAAATTGCCCACCGACAGCACAAACTAGAAGGGGCTCTGTTGGCCCTTG GTCAGTTCCAGCATGCCTTAGAGGAACTAATGAGTTGGCTGACTCATACCG AAGAGTTGTTAGATGCTCAGAGACCAATAAGTGGAGACCCAAAAGTCATTG AAGTTGAGCTCGCAAAGCACCATGTCCTAAAAAATGATGTTTTGGCTCATC AAGCCACAGTGGAAACAGTCAACAAAGCTGGCAATGAGCTTCTTGAATCCA GTGCTGGAGATGATGCCAGCAGCTTAAGGAGCCGTTTGGAAGCCATGAACC AATGCTGGGAGTCAGTGTTACAGAAAACAGAGGAGAGGGAGCAGCAGCTT CAGTCAACTCTGCAGCAGGCCCAGGGCTTCCACAGTGAAATTGAAGATTTC CTCTTGGAACTTACTAGAATGGAGAGCCAGCTTTCTGCATCTAAGCCCACA GGAGGACTTCCTGAAACTGCTAGGGAACAGCTTGATACACATATGGAACTC TATTCCCAGCTGAAAGCCAAGGAAGAGACTTATAATCAACTACTTGACAAG GGCAGACTCATGCTTCTAAGCCGTGACGACTCTGGGTCTGGCTCCAAGACA GAACAGAGTGTAGCACTTTTGGAGCAGAAGTGGCATGTGGTCAGCAGTAAG ATGGAAGAAAGAAAGTCAAAGCTGGAAGAGGCCCTCAACTTGGCAACAGA ATTCCAGAATTCCCTACAAGAATTTATCAACTGGCTCACTCTAGCAGAGCA GAGTTTAAACATCGCTTCTCCACCAAGCCTGATTCTAAATACTGTCCTTTCC CAGATAGAAGAGCACAAGGTTTTTGCTAATGAAGTAAATGCTCATCGAGAC CAGATCATTGAGCTGGATCAAACTGGGAATCAATTAAAGTTCCTTAGCCAA AAGCAGGATGTTGTTCTGATCAAGAATTTGTTGGTGAGCGTGCAGTCTCGA TGGGAGAAGGTTGTCCAGCGATCTATTGAAAGAGGGCGATCACTAGATGAT GCCAGGAAGCGGGCAAAACAATTCCATGAAGCTTGGAAAAAACTGATTGA CTGGCTAGAAGATGCAGAGAGTCACCTGGACTCAGAACTAGAGATATCCAA TGACCCAGACAAAATTAAACTTCAGCTTTCTAAGCATAAGGAGTTTCAGAA GACTCTTGGTGGCAAGCAGCCTGTGTATGATACCACAATTAGAACTGGCAG AGCACTGAAAGAAAAGACTTTGCTTCCCGAAGATAGTCAGAAACTTGACAA TTTCCTAGGAGAAGTCAGAGACAAATGGGATACTGTTTGTGGCAAGTCTGT GGAGCGGCAGCACAAGTTGGAGGAAGCCCTGCTCTTTTCGGGTCAGTTCAT GGATGCTTTGCAGGCATTGGTTGACTGGTTATACAAGGTGGAGCCACAGCT GGCTGAGGACCAGCCCGTGCACGGGGACCTTGACCTCGTCATGAACCTCAT GGATGCACACAAGGTTTTCCAGAAGGAACTGGGAAAGCGAACAGGAACCG TTCAGGTCCTGAAGCGGTCAGGCCGAGAGCTGATTGAGAATAGTCGAGATG ACACCACTTGGGTAAAAGGACAGCTCCAGGAACTGAGCACTCGCTGGGAC ACTGTCTGTAAACTCTCTGTTTCCAAACAAAGCCGGCTTGAGCAGGCCTTAA AACAAGCGGAAGTGTTTCGAGACACAGTCCACATGCTGTTGGAGTGGCTTT CTGAAGCAGAGCAAACGCTTCGCTTTCGGGGAGCACTTCCTGATGACACAG AGGCCCTGCAGTCTCTCATTGACACCCATAAGGAATTCATGAAGAAAGTAG AAGAAAAGCGAGTGGACGTTAACTCAGCAGTAGCCATGGGAGAAGTCATC CTGGCTGTCTGCCACCCCGATTGCATCACAACCATCAAACACTGGATCACC ATCATCCGAGCTCGCTTCGAGGAGGTCCTGACATGGGCTAAGCAGCACCAG CAGCGTCTTGAAACGGCCTTGTCAGAACTGGTGGCTAATGCTGAGCTCCTG GAAGAACTTCTGGCATGGATCCAGTGGGCTGAGACCACCCTCATTCAGCGG GATCAGGAGCCAATCCCGCAGAACATTGACCGAGTTAAAGCCCTTATCGCT GAGCATCAGACATTTATGGAGGAGATGACTCGCAAACAGCCTGACGTGGAC CGGGTCACCAAGACATACAAAAGGAAAAACATAGAGCCTACTCACGCGCC TTTCATAGAGAAATCCCGCAGCGGAGGCAGGAAATCCCTAAGTCAGCCAAC CCCTCCTCCCATGCCAATCCTTTCACAGTCTGAAGCAAAAAACCCACGGAT CAACCAGCTTTCTGCCCGCTGGCAGCAGGTGTGGCTGTTAGCACTGGAGCG GCAAAGGAAACTGAATGATGCCTTGGATCGGCTGGAGGAGTTGAAAGAAT TTGCCAACTTTGACTTTGATGTCTGGAGGAAAAAGTATATGCGTTGGATGA ATCACAAAAAGTCTCGAGTGATGGATTTCTTCCGGCGCATTGATAAGGACC AGGATGGGAAGATAACACGTCAGGAGTTTATCGATGGCATTTTAGCATCCA AGTTCCCCACCACCAAGTTAGAGATGACTGCTGTGGCTGACATTTTCGACC GAGATGGGGATGGTTACATTGATTATTATGAATTTGTGGCTGCTCTTCATCC CAACAAGGATGCGTATCGACCAACAACCGATGCAGATAAAATCGAAGATG AGGTTACAAGACAAGTGGCTCAGTGCAAATGTGCAAAAAGGTTTCAGGTGG AGCAGATCGGAGAGAATAAATACCGGTTTGGGGATTCTCAGCAGTTGCGGC TGGTCCGTATTCTGCGCAGCACCGTGATGGTTCGCGTTGGTGGAGGATGGA TGGCCTTGGATGAATTTTTAGTGAAAAATGATCCCTGCCGAGCACGAGGTA GAACTAACATTGAACTTAGAGAGAAATTCATCCTACCAGAGGGAGCATCCC AGGGAATGACCCCCTTCCGCTCACGGGGTCGAAGGTCCAAACCATCTTCCC GGGCAGCTTCCCCTACTCGTTCCAGCTCCAGTGCTAGTCAGAGTAACCACA GCTGTACATCCATGCCATCTTCTCCAGCCACCCCAGCCAGTGGAACCAAGG TTATCCCATCATCAGGTAGCAAGTTGAAACGACCAACACCAACTTTTCATTC TAGTCGGACATCCCTTGCTGGTGATACCAGCAATAGTTCTTCCCCGGCCTCC ACAGGTGCCAAAACTAATCGGGCAGACCCTAAAAAGTCTGCCAGTCGCCCT GGGAGTCGGGCTGGGAGTCGAGCCGGGAGTCGAGCCAGCAGCCGGCGAGG AAGTGACGCTTCTGACTTTGACCTCTTAGAGACGCAGTCTGCTTGTTCCGAC ACTTCAGAAAGCAGCGCTGCAGGGGGCCAAGGCAACTCCAGGAGAGGGCT AAACAAACCTTCCAAAATCCCAACCATGTCTAAGAAGACCACCACTGCCTC CCCCAGGACTCCAGGTCCCAAGCGATAA PGAP3-> ATGGCCGGCCTGGCGGCGCGGTTGGTCCTGCTAGCTGGGGCAGCGGCGCTG SEQ ID CACNB 1 GCGAGCGGCTCCCAGGGCGACCGTGAGCCGGTGTACCGCGACTGCGTACTG NO:23 CAGTGCGAAGAGCAGAACTGCTCTGGGGGCGCTCTGAATCACTTCCGCTCC CGCCAGCCAATCTACATGAGTCTAGCAGGCTGGACCTGTCGGGACGACTGT AAGTATGAGTGTATGTGGGTCACCGTTGGGCTCTACCTCCAGGAAGGTCAC AAAGTGCCTCAGTTCCATGGCAAGTGGCCCTTCTCCCGGTTCCTGTTCTTTC AAGAGCCGGCATCGGCCGTGGCCTCGTTTCTCAATGGCCTGGCCAGCCTGG TGATGCTCTGCCGCTACCGCACCTTCGTGCCAGCCTCCTCCCCCATGTACCA CACCTGTGTGGCCTTCGCCTGGGAAATGTTTGACATCATCCTGGATGAGAA CCAATTGGAGGATGCCTGCGAGCATCTGGCGGAGTACTTGGAAGCCTATTG GAAGGCCACACACCCGCCCAGCAGCACGCCACCCAATCCGCTGCTGAACCG CACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCCTGTCTCCAACCTC CAGGGACCCTACCTTGCTTCCGGGGACCAGCCACTGGAACGGGCCACCGGG GAGCACGCCAGCATGCACGAGTACCCAGGGGAGCTGGGCCAGCCCCCAGG CCTTTACCCCAGCAGCCACCCACCAGGCCGGGCAGGCACGCTACGGGCACT GTCCCGCCAAGACACTTTTGATGCCGACACCCCCGGCAGCCGAAACTCTGC CTACACGGAGCTGGGAGACTCATGTGTGGACATGGAGACTGACCCCTCAGA GGGGCCAGGGCTTGGAGACCCTGCAGGGGGCGGCACGCCCCCAGCCCGAC AGGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGAGCTGACCGAC AACCGGAACCGGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGG TCCAGTTTTGGGGCGCAACAAGAATGAGCTGGAGGGCTGGGGACGAGGCG TCTACATTCGCTGA STAUl-> CACTTCCTGCCGGGCTGCGGGCGCCTGAGCGGCTCTTCAGCGTTTGCGCCG SEQ ID TOPI GCGGCTGCCGCGTCTCTCTCGGCTCCCGCTTCCTTTGACCGCCTCCCCCCCC NO:24 CGGCCCGGCGGCGCCCGCCTCCTCCACGGCCACTCCGCCTCTTCCCTCCCTT CGTCCCTTCTTCCTCTCCCTTTTTTCCTTCTTCCTTCCCCTCCTCGCCGCCACC GCCCAGGACCGCCGGCCGGGGGACGAGCTCGGAGCAGCAGCCAGGTGGAG TTTTGCTCTTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTG CAACCTCCACCTCCCAGGTTCAAGCGATTTTCCCACTTCAGCCTCCCGATAA GCTGAGATTACAGAGTTTATTAACCACTTAACCTCTCAGAACTGAACAAAG ACAACATTGTTCCTGGAACGCCCTCTTTTTAAAAAAGATTCTCATAAACACA AAGATAAACACAAAGATCGAGAACACCGGCACAAAGAACACAAGAAGGA GAAGGACCGGGAAAAGTCCAAGCATAGCAACAGTGAACATAAAGATTCTG AAAAGAAACACAAAGAGAAGGAGAAGACCAAACACAAAGATGGAAGCTC AGAAAAGCATAAAGACAAACATAAAGACAGAGACAAGGAAAAACGAAAA GAGGAAAAGGTTCGAGCCTCTGGGGATGCAAAAATAAAGAAGGAGAAGGA AAATGGCTTCTCTAGTCCACCACAAATTAAAGATGAACCTGAAGATGATGG CTATTTTGTTCCTCCTAAAGAGGATATAAAGCCATTAAAGAGACCTCGAGA TGAGGATGATGCTGATTATAAACCTAAGAAAATTAAAACAGAAGATACCA AGAAGGAGAAGAAAAGAAAACTAGAAGAAGAAGAGGATGGTAAATTGAA AAAACCCAAGAATAAAGATAAAGATAAAAAAGTTCCTGAGCCAGATAACA AGAAAAAGAAGCCGAAGAAAGAAGAGGAACAGAAGTGGAAATGGTGGGA AGAAGAGCGCTATCCTGAAGGCATCAAGTGGAAATTCCTAGAACATAAAG GTCCAGTATTTGCCCCACCATATGAGCCTCTTCCAGAGAATGTCAAGTTTTA TTATGATGGTAAAGTCATGAAGCTGAGCCCCAAAGCAGAGGAAGTAGCTAC GTTCTTTGCAAAAATGCTCGACCATGAATATACTACCAAGGAAATATTTAG GAAAAATTTCTTTAAAGACTGGAGAAAGGAAATGACTAATGAAGAGAAGA ATATTATCACCAACCTAAGCAAATGTGATTTTACCCAGATGAGCCAGTATTT CAAAGCCCAGACGGAAGCTCGGAAACAGATGAGCAAGGAAGAGAAACTGA AAATCAAAGAGGAGAATGAAAAATTACTGAAAGAATATGGATTCTGTATTA TGGATAACCACAAAGAGAGGATTGCTAACTTCAAGATAGAGCCTCCTGGAC TTTTCCGTGGCCGCGGCAACCACCCCAAGATGGGCATGCTGAAGAGACGAA TCATGCCCGAGGATATAATCATCAACTGTAGCAAAGATGCCAAGGTTCCTT CTCCTCCTCCAGGACATAAGTGGAAAGAAGTCCGGCATGATAACAAGGTTA CTTGGCTGGTTTCCTGGACAGAGAACATCCAAGGTTCCATTAAATACATCAT GCTTAACCCTAGTTCACGAATCAAGGGTGAGAAGGACTGGCAGAAATACG AGACTGCTCGGCGGCTGAAAAAATGTGTGGACAAGATCCGGAACCAGTATC GAGAAGACTGGAAGTCCAAAGAGATGAAAGTCCGGCAGAGAGCTGTAGCC CTGTACTTCATCGACAAGCTTGCTCTGAGAGCAGGCAATGAAAAGGAGGAA GGAGAAACAGCGGACACTGTGGGCTGCTGCTCACTTCGTGTGGAGCACATC AATCTACACCCAGAGTTGGATGGTCAGGAATATGTGGTAGAGTTTGACTTC CTCGGGAAGGACTCCATCAGATACTATAACAAGGTCCCTGTTGAGAAACGA GTTTTTAAGAACCTACAACTATTTATGGAGAACAAGCAGCCCGAGGATGAT CTTTTTGATAGACTCAATACTGGTATTCTGAATAAGCATCTTCAGGATCTCA TGGAGGGCTTGACAGCCAAGGTATTCCGTACATACAATGCCTCCATCACGC TACAGCAGCAGCTAAAAGAACTGACAGCCCCGGATGAGAACATCCCAGCG AAGATCCTTTCTTATAACCGTGCCAATCGAGCTGTTGCAATTCTTTGTAACC ATCAGAGGGCACCACCAAAAACTTTTGAGAAGTCTATGATGAACTTGCAAA CTAAGATTGATGCCAAGAAGGAACAGCTAGCAGATGCCCGGAGAGACCTG AAAAGTGCTAAGGCTGATGCCAAGGTCATGAAGGATGCAAAGACGAAGAA GGTAGTAGAGTCAAAGAAGAAGGCTGTTCAGAGACTGGAGGAACAGTTGA TGAAGCTGGAAGTTCAAGCCACAGACCGAGAGGAAAATAAACAGATTGCC CTGGGAACCTCCAAACTCAATTATCTGGACCCTAGGATCACAGTGGCTTGG TGCAAGAAGTGGGGTGTCCCAATTGAGAAGATTTACAACAAAACCCAGCG GGAGAAGTTTGCCTGGGCCATTGACATGGCTGATGAAGACTATGAGTTTTA GCCAGTCTCAAGAGGCAGAGTTCTGTGAAGAGGAACAGTGTGGTTTGGGAA AGATGGATAAACTGAGCCTCACTTGCCCTCGTGCCTGGGGGAGAGAGGCAG CAAGTCTTAACAAACCAACATCTTTGCGAAAAGATAAACCTGGAGATATTA TAAGGGAGAGCTGAGCCAGTTGTCCTATGGACAACTTATTTAAAAATATTT CAGATATCAAAATTCTAGCTGTATGATTTGTTTTGAATTTTGTTTTTATTTTC AAGAGGGCAAGTGGATGGGAATTTGTCAGCGTTCTACCAGGCAAATTCACT GTTTCACTGAAATGTTTGGATTCTCTTAGCTACTGTATGCAAAGTCCGATTA TATTGGTGCGTTTTTACAGTTAGGGTTTTGCAATAACTTCTATATTTTAATAG AAATAAATTCCTAAACTCCCTTCCCTCTCTCCCATTTCAGGAATTTAAAATT AAGTAGAACAAAAAACCCAGCGCACCTGTTAGAGTCGTCACTCTCTATTGT CATGGGGATCAATTTTCATTAAACTTGAAGCAGTCGTGGCTTTGGCAGTGTT TTGGTTCAGACACCTGTTCACAGAAAAAGCATGATGGGAAAATATTTCCTG ACTTGAGTGTTCCTTTTTAAATGTGAATTTTTATTTCTTTTTAATTATTTTAA AATATTTAAACCTTTTTCTTGATCTTAAAGATCGTGTAGATTGGGGTTGGGG AGGGATGAAGGGCGAGTGAATCTAAGGATAATGAAATAATCAGTGACTGA AACCATTTTCCCATCATCCTTTGTTCTGAGCATTCGCTGTACCCTTTAAGATA TCCATCTTTTTCTTTTTAACCCTAATCTTTCACTTGAAAGATTTTATTGTATA AAAAGTTTCACAGGTCAATAAACTTAGAGGAAAATGAGTATTTGGTCCAAA AAAAGGAAAAATAATCAAGATTTTAGGGCTTTTATTTTTTCTTTTGTAATTG TGTAAAAAATGGAAAAAAACATAAAAAGCAGAATTTTAATGTGAAGACAT TTTTTGCTATAATCATTAGTTTTAGAGGCATTGTTAGTTTAGTGTGTGTGCA GAGTCCATTTCCCACATCTTTCCTCAAGTATCTTCTATTTTTATCATGAATTC CCTTTTAATCAACTGTAGGTTATTTAAAATAAATTCCTACAACTTAATGGAA A FBXW7-> ATGAATCAGGAACTGCTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGG SEQ ID MLL3 CTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAA NO:25 TCGTGTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGG AGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGA GGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATT TATTTCGGTAGATGAGGACTCCTCAGGAAACCAAGAAGAACAAGAGGAAG ATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGA GATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGA AGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGA CCTGCCCGTTCACCAACTCTCCTCCCCATTCTATACAAAAACAACAAAAAC CTCGAAGTAGGGGGAAAACTGCAGTGGAAGATGAGGACAGCATGGATGGG CTGGAGACAACAGAAACAGAAACGATTGTGGAAACAGAAATCAAAGAACA ATCTGCAGAAGAGGATGCTGAAGCAGAAGTGGATAACAGCAAACAGCTAA TTCCAACTCTTCAGCGATCTGTGTCTGAGGAATCGGCAAACTCCCTGGTCTC TGTTGGTGTAGAAGCCAAAATCAGTGAACAGCTCTGCGCTTTTTGTTACTGT GGGGAAAAAAGTTCCTTAGGACAAGGAGACTTAAAACAATTCAGAATAAC GCCTGGATTTATCTTGCCATGGAGAAACCAACCTTCTAACAAGAAGGACAT TGATGACAACAGCAATGGAACCTATGAGAAAATGCAAAACTCAGCACCAC GAAAACAAAGAGGACAGAGAAAAGAACGATCTCCTCAGCAGAATATAGTA TCTTGTGTAAGTGTAAGCACCCAGACAGCTTCAGATGATCAAGCTGGTAAA CTGTGGGATGAACTCAGTCTGGTTGGGCTTCCAGATGCCATTGATATCCAA GCCTTATTTGATTCTACAGGCACTTGTTGGGCTCATCACCGTTGTGTGGAGT GGTCACTAGGAGTATGCCAGATGGAAGAACCATTGTTAGTGAACGTGGACA AAGCTGTTGTCTCAGGGAGCACAGAACGATGTGCATTTTGTAAGCACCTTG GAGCCACTATCAAATGCTGTGAAGAGAAATGTACCCAGATGTATCATTATC CTTGTGCTGCAGGAGCCGGCACCTTTCAGGATTTCAGTCACATCTTCCTGCT TTGTCCAGAACACATTGACCAAGCTCCTGAAAGATCGAAGGAAGATGCAAA CTGTGCAGTGTGCGACAGCCCGGGAGACCTCTTAGATCAGTTCTTTTGTACT ACTTGTGGTCAGCACTATCATGGAATGTGCCTGGATATAGCGGTTACTCCAT TAAAACGTGCAGGTTGGCAATGTCCTGAGTGCAAAGTGTGCCAGAACTGCA AACAATCGGGAGAAGATAGCAAGATGCTAGTGTGTGATACGTGTGACAAA GGGTATCATACTTTTTGTCTTCAACCAGTTATGAAATCAGTACCAACCAATG GCTGGAAATGCAAAAATTGCAGAATATGTATAGAGTGTGGCACACGGTCTA GTTCTCAGTGGCACCACAATTGCCTGATATGTGACAATTGTTACCAACAGC AGGATAACTTATGTCCCTTCTGTGGGAAGTGTTATCATCCAGAATTGCAGA AAGACATGCTTCATTGTAATATGTGCAAAAGGTGGGTTCACCTAGAGTGTG ACAAACCAACAGATCATGAACTGGATACTCAGCTCAAAGAAGAGTATATCT GCATGTATTGTAAACACCTGGGAGCTGAGATGGATCGTTTACAGCCAGGTG AGGAAGTGGAGATAGCTGAGCTCACTACAGATTATAACAATGAAATGGAA GTTGAAGGCCCTGAAGATCAAATGGTATTCTCAGAGCAGGCAGCTAATAAA GATGTCAACGGTCAGGAGTCCACTCCTGGAATTGTTCCAGATGCGGTTCAA GTCCACACTGAAGAGCAACAGAAGAGTCATCCCTCAGAAAGTCTTGACACA GATAGTCTTCTTATTGCTGTATCATCCCAACATACAGTGAATACTGAATTGG AAAAACAGATTTCTAATGAAGTTGATAGTGAAGACCTGAAAATGTCTTCTG AAGTGAAGCATATTTGTGGCGAAGATCAAATTGAAGATAAAATGGAAGTG ACAGAAAACATTGAAGTCGTTACACACCAGATCACTGTGCAGCAAGAACA ACTGCAGTTGTTAGAGGAACCTGAAACAGTGGTATCCAGAGAAGAATCAA GGCCTCCAAAATTAGTCATGGAATCTGTCACTCTTCCACTAGAAACCTTAGT GTCCCCACATGAGGAAAGTATTTCATTATGTCCTGAGGAACAGTTGGTTAT AGAAAGGCTACAAGGAGAAAAGGAACAGAAAGAAAATTCTGAACTTTCTA CTGGATTGATGGACTCTGAAATGACTCCTACAATTGAGGGTTGTGTGAAAG ATGTTTCATACCAAGGAGGCAAATCTATAAAGTTATCATCTGAGACAGAGT CATCATTTTCATCATCAGCAGACATAAGCAAGGCAGATGTGTCTTCCTCCCC AACACCTTCTTCAGACTTGCCTTCGCATGACATGCTGCATAATTACCCTTCA GCTCTTAGTTCCTCTGCTGGAAACATCATGCCAACAACTTACATCTCAGTCA CTCCAAAAATTGGCATGGGTAAACCAGCTATTACTAAGAGAAAATTTTCTC CTGGTAGACCTCGGTCCAAACAGGGGGCTTGGAGTACCCATAATACAGTGA GCCCACCTTCCTGGTCCCCAGACATTTCAGAAGGTCGGGAAATTTTTAAACC CAGGCAGCTTCCTGGCAGTGCCATTTGGAGCATCAAAGTGGGCCGTGGGTC TGGATTTCCAGGAAAGCGGAGACCTCGAGGTGCAGGACTGTCGGGGCGAG GTGGCCGAGGCAGGTCAAAGCTGAAAAGTGGAATCGGAGCTGTTGTATTAC CTGGGGTGTCTACTGCAGATATTTCATCAAATAAGGATGATGAAGAAAACT CTATGCACAATACAGTTGTGTTGTTTTCTAGCAGTGACAAGTTCACTTTGAA TCAGGATATGTGTGTAGTTTGTGGCAGTTTTGGCCAAGGAGCAGAAGGAAG ATTACTTGCCTGTTCTCAGTGTGGTCAGTGTTACCATCCATACTGTGTCAGT ATTAAGATCACTAAAGTGGTTCTTAGCAAAGGTTGGAGGTGTCTTGAGTGC ACTGTGTGTGAGGCCTGTGGGAAGGCAACTGACCCAGGAAGACTCCTGCTG TGTGATGACTGTGACATAAGTTATCACACCTACTGCCTAGACCCTCCATTGC AGACAGTTCCCAAAGGAGGCTGGAAGTGCAAATGGTGTGTTTGGTGCAGAC ACTGTGGAGCAACATCTGCAGGTCTAAGATGTGAATGGCAGAACAATTACA CACAGTGCGCTCCTTGTGCAAGCTTATCTTCCTGTCCAGTCTGCTATCGAAA CTATAGAGAAGAAGATCTTATTCTGCAATGTAGACAATGTGATAGATGGAT GCATGCAGTTTGTCAGAACTTAAATACTGAGGAAGAAGTGGAAAATGTAGC AGACATTGGTTTTGATTGTAGCATGTGCAGACCCTATATGCCTGCGTCTAAT GTGCCTTCCTCAGACTGCTGTGAATCTTCACTTGTAGCACAAATTGTCACAA AAGTAAAAGAGCTAGACCCACCCAAGACTTATACCCAGGATGGTGTGTGTT TGACTGAATCAGGGATGACTCAGTTACAGAGCCTCACAGTTACAGTTCCAA GAAGAAAACGGTCAAAACCAAAATTGAAATTGAAGATTATAAATCAGAAT AGCGTGGCCGTCCTTCAGACCCCTCCAGACATCCAATCAGAGCATTCAAGG GATGGTGAAATGGATGATAGTCGAGAAGGAGAACTTATGGATTGTGATGG AAAATCAGAATCTAGTCCTGAGCGGGAAGCTGTGGATGATGAAACTAAGG GAGTGGAAGGAACAGATGGTGTCAAAAAGAGAAAAAGGAAACCATACAG ACCAGGTATTGGTGGATTTATGGTGCGGCAAAGAAGTCGAACTGGGCAAGG GAAAACCAAAAGATCTGTGATCAGAAAAGATTCCTCAGGCTCTATTTCCGA GCAGTTACCTTGCAGAGATGATGGCTGGAGTGAGCAGTTACCAGATACTTT AGTTGATGAATCTGTTTCTGTTACTGAAAGCACTGAAAAAATAAAGAAGAG ATACCGAAAAAGGAAAAATAAGCTTGAAGAAACTTTCCCTGCCTATTTACA AGAAGCTTTCTTTGGAAAAGATCTTCTAGATACAAGTAGACAAAGCAAGAT AAGTTTAGATAATCTGTCAGAAGATGGAGCTCAGCTTTTATATAAAACAAA CATGAACACAGGTTTCTTGGATCCTTCCTTAGATCCACTACTTAGTTCATCC TCGGCTCCAACAAAATCTGGAACTCACGGTCCTGCTGATGACCCATTAGCT GATATTTCTGAAGTTTTAAACACAGATGATGACATTCTTGGAATAATTTCAG ATGATCTAGCAAAATCAGTTGATCATTCAGATATTGGTCCTGTCACTGATGA TCCTTCCTCTTTGCCTCAGCCAAATGTCAATCAGAGTTCACGACCATTAAGT GAAGAACAGCTAGATGGGATCCTCAGTCCTGAACTAGACAAAATGGTCACA GATGGAGCAATTCTTGGAAAATTATATAAAATTCCAGAGCTTGGCGGAAAA GATGTTGAAGACTTATTTACAGCTGTACTTAGTCCTGCGAACACTCAGCCAA CTCCATTGCCACAGCCTCCCCCACCAACACAGCTGTTGCCAATACACAATC AGGATGCTTTTTCACGGATGCCTCTCATGAATGGCCTTATTGGATCCAGTCC TCATCTCCCACATAATTCTTTGCCACCTGGAAGCGGACTGGGAACTTTCTCT GCAATTGCACAATCCTCTTATCCTGATGCCAGGGATAAAAATTCAGCCTTTA ATCCAATGGCAAGTGATCCTAACAACTCTTGGACATCATCAGCTCCCACTGT GGAAGGAGAAAATGACACAATGTCGAATGCCCAGAGAAGCACGCTTAAGT GGGAGAAAGAGGAGGCTCTGGGTGAAATGGCAACTGTTGCCCCAGTTCTCT ACACCAATATTAATTTCCCCAACTTAAAGGAAGAATTCCCTGATTGGACTA CTAGAGTGAAGCAAATTGCCAAATTGTGGAGAAAAGCAAGCTCACAAGAA AGAGCACCATATGTGCAAAAAGCCAGAGATAACAGAGCTGCTTTACGCATT AATAAAGTACAGATGTCAAATGATTCCATGAAAAGGCAGCAACAGCAAGA TAGCATTGATCCCAGCTCTCGTATTGATTCGGAGCTTTTTAAAGATCCTTTA AAGCAAAGAGAATCAGAACATGAACAGGAATGGAAATTTAGACAGCAAAT GCGTCAGAAAAGTAAGCAGCAAGCTAAAATTGAAGCCACACAGAAACTTG AACAGGTGAAAAATGAGCAGCAGCAGCAGCAACAACAGCAATTTGGTTCT CAGCATCTTCTGGTGCAGTCTGGTTCAGATACACCAAGTAGTGGGATACAG AGTCCCTTGACACCTCAGCCTGGCAATGGAAATATGTCTCCTGCACAGTCAT TCCATAAAGAACTGTTTACAAAACAGCCACCCAGTACCCCTACGTCTACAT CTTCAGATGATGTGTTTGTAAAGCCACAAGCTCCACCTCCTCCTCCAGCCCC ATCCCGGATTCCCATCCAGGATAGTCTTTCTCAGGCTCAGACTTCTCAGCCA CCCTCACCGCAAGTGTTTTCACCTGGGTCCTCTAACTCACGACCACCATCTC CAATGGATCCATATGCAAAAATGGTTGGTACCCCTCGACCACCTCCTGTGG GCCATAGTTTTTCCAGAAGAAATTCTGCTGCACCAGTGGAAAACTGTACAC CTTTATCATCGGTATCTAGGCCCCTTCAAATGAATGAGACAACAGCAAATA GGCCATCCCCTGTCAGAGATTTATGTTCTTCTTCCACGACAAATAATGACCC CTATGCAAAACCTCCAGACACACCTAGGCCTGTGATGACAGATCAATTTCC CAAATCCTTGGGCCTATCCCGGTCTCCTGTAGTTTCAGAACAAACTGCAAA AGGCCCTATAGCAGCTGGAACCAGTGATCACTTTACTAAACCATCTCCTAG GGCAGATGTGTTTCAAAGACAAAGGATACCTGACTCATATGCACGACCCTT GTTGACACCTGCACCTCTTGATAGTGGTCCTGGACCTTTTAAGACTCCAATG CAACCTCCTCCATCCTCTCAGGATCCTTATGGATCAGTGTCACAGGCATCAA GGCGATTGTCTGTTGACCCTTATGAAAGGCCTGCTTTGACACCAAGACCTAT AGATAATTTTTCTCATAATCAGTCAAATGATCCATATAGTCAGCCTCCCCTT ACCCCACATCCAGCAGTGAATGAATCTTTTGCCCATCCTTCAAGGGCTTTTT CCCAGCCTGGAACCATATCAAGGCCAACATCTCAGGACCCATACTCCCAAC CCCCAGGAACTCCACGACCTGTTGTAGATTCTTATTCCCAATCTTCAGGAAC AGCTAGGTCCAATACAGACCCTTACTCTCAACCTCCTGGAACTCCCCGGCCT ACTACTGTTGACCCATATAGTCAGCAGCCCCAAACCCCAAGACCATCTACA CAAACTGACTTGTTTGTTACACCTGTAACAAATCAGAGGCATTCTGATCCAT ATGCTCATCCTCCTGGAACACCAAGACCTGGAATTTCTGTCCCTTACTCTCA GCCACCAGCAACACCAAGGCCAAGGATTTCAGAGGGTTTTACTAGGTCCTC AATGACAAGACCAGTCCTCATGCCAAATCAGGATCCTTTCCTGCAAGCAGC ACAAAACCGAGGACCAGCTTTACCTGGCCCGTTGGTAAGGCCACCTGATAC ATGTTCCCAGACACCTAGGCCCCCTGGACCTGGTCTTTCAGACACATTTAGC CGTGTTTCCCCATCTGCTGCCCGTGATCCCTATGATCAGTCTCCAATGACTC CAAGATCTCAGTCTGACTCTTTTGGAACAAGTCAAACTGCCCATGATGTTGC TGATCAGCCAAGGCCTGGATCAGAGGGGAGCTTCTGTGCATCTTCAAACTC TCCAATGCACTCCCAAGGCCAGCAGTTCTCTGGTGTCTCCCAACTTCCTGGA CCTGTGCCAACTTCAGGAGTAACTGATACACAGAATACTGTAAATATGGCC CAAGCAGATACAGAGAAATTGAGACAGCGGCAGAAGTTACGTGAAATCAT TCTCCAGCAGCAACAGCAGAAGAAGATTGCAGGTCGACAGGAGAAGGGGT CACAGGACTCACCCGCAGTGCCTCATCCAGGGCCTCTTCAACACTGGCAAC CAGAGAATGTTAACCAGGCTTTCACCAGACCCCCACCTCCCTATCCTGGGA ACATTAGGTCTCCTGTTGCCCCTCCTTTAGGACCTAGATATGCTGTTTTCCC AAAAGATCAGCGTGGACCCTATCCTCCTGATGTTGCTAGTATGGGGATGAG ACCTCATGGATTTAGATTTGGATTTCCAGGAGGTAGTCATGGTACCATGCCG AGTCAAGAGCGCTTCCTTGTGCCTCCTCAGCAAATACAGGGATCTGGAGTT TCTCCACAGCTAAGAAGATCAGTATCTGTAGATATGCCTAGGCCTTTAAAT AACTCACAAATGAATAATCCAGTTGGACTTCCTCAGCATTTTTCACCACAGA GCTTGCCAGTTCAGCAGCACAACATACTGGGCCAAGCATATATTGAACTGA GACATAGGGCTCCTGACGGAAGGCAACGGCTGCCTTTCAGTGCTCCACCTG GCAGCGTTGTAGAGGCATCTTCTAATCTGAGACATGGAAACTTCATTCCCC GGCCAGACTTTCCGGGCCCTAGACACACAGACCCCATGCGACGACCTCCCC AGGGTCTACCTAATCAGCTACCTGTGCACCCAGATTTGGAACAAGTGCCAC CATCTCAACAAGAGCAAGGTCATTCTGTCCATTCATCTTCTATGGTCATGAG GACTCTGAACCATCCACTAGGTGGTGAATTTTCAGAAGCTCCTTTGTCAACA TCTGTACCGTCTGAAACAACGTCTGATAATTTACAGATAACCACCCAGCCTT CTGATGGTCTAGAGGAAAAACTTGATTCTGATGACCCTTCTGTGAAGGAAC TGGATGTTAAAGACCTTGAGGGGGTTGAAGTCAAAGACTTAGATGATGAAG ATCTTGAAAACTTAAATTTAGATACAGAGGATGGCAAGGTAGTTGAATTGG ATACTTTAGATAATTTGGAAACTAATGATCCCAACCTGGATGACCTCTTAAG GTCAGGAGAGTTTGATATCATTGCATATACAGATCCAGAACTTGACATGGG AGATAAGAAAAGCATGTTTAATGAGGAACTAGACCTTCCAATTGATGATAA GTTAGATAATCAGTGTGTATCTGTTGAACCAAAAAAAAAGGAACAAGAAA ACAAAACTCTGGTTCTCTCTGATAAACATTCACCACAGAAAAAATCCACTG TTACCAATGAGGTAAAAACGGAAGTACTGTCTCCAAATTCTAAGGTGGAAT CCAAATGTGAAACTGAAAAAAATGATGAGAATAAAGATAATGTTGACACT CCTTGCTCACAGGCTTCTGCTCACTCAGACCTAAATGATGGAGAAAAGACT TCTTTGCATCCTTGTGATCCAGATCTATTTGAGAAAAGAACCAATCGAGAA ACTGCTGGCCCCAGTGCAAATGTCATTCAGGCATCCACTCAACTACCTGCTC AAGATGTAATAAACTCTTGTGGCATAACTGGATCAACTCCAGTTCTCTCAA GTTTACTTGCTAATGAGAAATCTGATAATTCAGACATTAGGCCATCGGGGT CTCCACCACCACCAACTCTGCCGGCCTCCCCATCCAATCATGTGTCAAGTTT GCCTCCTTTCATAGCACCGCCTGGCCGTGTTTTGGATAATGCCATGAATTCT AATGTGACAGTAGTCTCTAGGGTAAACCATGTTTTTTCTCAGGGTGTGCAGG TAAACCCAGGGCTCATTCCAGGTCAATCAACAGTTAACCACAGTCTGGGGA CAGGAAAACCTGCAACTCAAACTGGGCCTCAAACAAGTCAGTCTGGTACCA GTAGCATGTCTGGACCCCAACAGCTAATGATTCCTCAAACATTAGCACAGC AGAATAGAGAGAGGCCCCTTCTTCTAGAAGAACAGCCTCTACTTCTACAGG ATCTTTTGGATCAAGAAAGGCAAGAACAGCAGCAGCAAAGACAGATGCAA GCCATGATTCGTCAGCGATCAGAACCGTTCTTCCCTAATATTGATTTTGATG CAATTACAGATCCTATAATGAAAGCCAAAATGGTGGCCCTTAAAGGTATAA ATAAAGTGATGGCACAAAACAATCTGGGCATGCCACCAATGGTGATGAGC AGGTTCCCTTTTATGGGCCAGGTGGTAACTGGAACACAGAACAGTGAAGGA CAGAACCTTGGACCACAGGCCATTCCTCAGGATGGCAGTATAACACATCAG ATTTCTAGGCCTAATCCTCCAAATTTTGGTCCAGGCTTTGTCAATGATTCAC AGCGTAAGCAGTATGAAGAGTGGCTCCAGGAGACCCAACAGCTGCTTCAA ATGCAGCAGAAGTATCTTGAAGAACAAATTGGTGCTCACAGAAAATCTAAG AAGGCCCTTTCAGCTAAACAACGTACTGCCAAGAAAGCTGGGCGTGAATTT CCAGAGGAAGATGCAGAACAACTCAAGCATGTTACTGAACAGCAAAGCAT GGTTCAGAAACAGCTAGAACAGATTCGTAAACAACAGAAAGAACATGCTG AATTGATTGAAGATTATCGGATCAAACAGCAGCAGCAATGTGCAATGGCCC CACCTACCATGATGCCCAGTGTCCAGCCCCAGCCACCCCTAATTCCAGGTG CCACTCCACCCACCATGAGCCAACCCACCTTTCCCATGGTGCCACAGCAGC TTCAGCACCAGCAGCACACAACAGTTATTTCTGGCCATACTAGCCCTGTTAG AATGCCCAGTTTACCTGGATGGCAACCCAACAGTGCTCCTGCCCACCTGCC CCTCAATCCTCCTAGAATTCAGCCCCCAATTGCCCAGTTACCAATAAAAACT TGTACACCAGCCCCAGGGACAGTCTCAAATGCAAATCCACAGAGTGGACCA CCACCTCGGGTAGAATTTGATGACAACAATCCCTTTAGTGAAAGTTTTCAA GAACGGGAACGTAAGGAACGTTTACGAGAACAGCAAGAGAGACAACGGAT CCAACTCATGCAGGAGGTAGATAGACAAAGAGCTTTGCAGCAGAGGATGG AAATGGAGCAGCATGGTATGGTGGGCTCTGAGATAAGTAGTAGTAGGACAT CTGTGTCCCAGATTCCCTTCTACAGTTCCGACTTACCTTGTGATTTTATGCAA CCTCTAGGACCCCTTCAGCAGTCTCCACAACACCAACAGCAAATGGGGCAG GTTTTACAGCAGCAGAATATACAACAAGGATCAATTAATTCACCCTCCACC CAAACTTTCATGCAGACTAATGAGCGAAGGCAGGTAGGCCCTCCTTCATTT GTTCCTGATTCACCATCAATCCCTGTTGGAAGCCCAAATTTTTCTTCTGTGA AGCAGGGACATGGAAATCTTTCTGGGACCAGCTTCCAGCAGTCCCCAGTGA GGCCTTCTTTTACACCTGCTTTACCAGCAGCACCTCCAGTAGCTAATAGCAG TCTCCCATGTGGCCAAGATTCTACTATAACCCATGGACACAGTTATCCGGG ATCAACCCAATCGCTCATTCAGTTGTATTCTGATATAATCCCAGAGGAAAA AGGGAAAAAGAAAAGAACAAGAAAGAAGAAAAGAGATGATGATGCAGAA TCCACCAAGGCTCCATCAACTCCCCATTCAGATATAACTGCCCCACCGACTC CAGGCATCTCAGAAACTACCTCTACTCCTGCAGTGAGCACACCCAGTGAGC TTCCTCAACAAGCCGACCAAGAGTCGGTGGAACCAGTCGGCCCATCCACTC CCAATATGGCAGCAGGCCAGCTATGTACAGAATTAGAGAACAAACTGCCCA ATAGTGATTTCTCACAAGCAACTCCAAATCAACAGACGTATGCAAATTCAG AAGTAGACAAGCTCTCCATGGAAACCCCTGCCAAAACAGAAGAGATAAAA CTGGAAAAGGCTGAGACAGAGTCCTGCCCAGGCCAAGAGGAGCCTAAATT GGAGGAACAGAATGGTAGTAAGGTAGAAGGAAACGCTGTAGCCTGTCCTG TCTCCTCAGCACAGAGTCCTCCCCATTCTGCTGGGGCCCCTGCTGCCAAAGG AGACTCAGGGAATGAACTTCTGAAACACTTGTTGAAAAATAAAAAGTCATC TTCTCTTTTGAATCAAAAACCTGAGGGCAGTATTTGTTCAGAAGATGACTGT ACAAAGGATAATAAACTAGTTGAGAAGCAGAACCCAGCTGAAGGACTGCA AACTTTGGGGGCTCAAATGCAAGGTGGTTTTGGATGTGGCAACCAGTTGCC AAAAACAGATGGAGGAAGTGAAACCAAGAAACAGCGAAGCAAACGGACT CAGAGGACGGGTGAGAAAGCAGCACCTCGCTCAAAGAAAAGGAAAAAGG ACGAAGAGGAGAAACAAGCTATGTACTCTAGCACTGACACGTTTACCCACT TGAAACAGCAGAATAATTTAAGTAATCCTCCAACACCCCCTGCCTCTCTTCC TCCTACACCACCTCCTATGGCTTGTCAGAAGATGGCCAATGGTTTTGCAACA ACTGAAGAACTTGCTGGAAAAGCCGGAGTGTTAGTGAGCCATGAAGTTACC AAAACTCTAGGACCTAAACCATTTCAGCTGCCCTTCAGACCCCAGGACGAC TTGTTGGCCCGAGCTCTTGCTCAGGGCCCCAAGACAGTTGATGTGCCAGCCT CCCTCCCAACACCACCTCATAACAATCAGGAAGAATTAAGGATACAGGATC ACTGTGGTGATCGAGATACTCCTGACAGTTTTGTTCCCTCATCCTCTCCTGA GAGTGTGGTTGGGGTAGAAGTGAGCAGGTATCCAGATCTGTCATTGGTCAA GGAGGAGCCTCCAGAACCGGTGCCGTCCCCCATCATTCCAATTCTTCCTAGC ACTGCTGGGAAAAGTTCAGAATCAAGAAGGAATGACATCAAAACTGAGCC AGGCACTTTATATTTTGCGTCACCTTTTGGTCCTTCCCCAAATGGTCCCAGA TCAGGTCTTATATCTGTAGCAATTACTCTGCATCCTACAGCTGCTGAGAACA TTAGCAGTGTTGTGGCTGCATTTTCCGACCTTCTTCACGTCCGAATCCCTAA CAGCTATGAGGTTAGCAGTGCTCCAGATGTCCCATCCATGGGTTTGGTCAGT AGCCACAGAATCAACCCGGGTTTGGAGTATCGACAGCATTTACTTCTCCGT GGGCCTCCGCCAGGATCTGCAAACCCTCCCAGATTAGTGAGCTCTTACCGG CTGAAGCAGCCTAATGTACCATTTCCTCCAACAAGCAATGGTCTTTCTGGAT ATAAGGATTCTAGTCATGGTATTGCAGAAAGCGCAGCACTCAGACCACAGT GGTGTTGTCATTGTAAAGTGGTTATTCTTGGAAGTGGTGTGCGGAAATCTTT CAAAGATCTGACCCTTTTGAACAAGGATTCCCGAGAAAGCACCAAGAGGGT AGAGAAGGACATTGTCTTCTGTAGTAATAACTGCTTTATTCTTTATTCATCA ACTGCACAAGCGAAAAACTCAGAAAACAAGGAATCCATTCCTTCATTGCCA CAATCACCTATGAGAGAAACGCCTTCCAAAGCATTTCATCAGTACAGCAAC AACATCTCCACTTTGGATGTGCACTGTCTCCCCCAGCTCCCAGAGAAAGCTT CTCCCCCTGCCTCACCACCCATCGCCTTCCCTCCTGCTTTTGAAGCAGCCCA AGTCGAGGCCAAGCCAGATGAGCTGAAGGTGACAGTCAAGCTGAAGCCTC GGCTAAGAGCTGTCCATGGTGGGTTTGAAGATTGCAGGCCGCTCAATAAAA AATGGAGAGGAATGAAATGGAAGAAGTGGAGCATTCATATTGTAATCCCTA AGGGGACATTTAAACCACCTTGTGAGGATGAAATAGATGAATTTCTAAAGA AATTGGGCACTTCCCTTAAACCTGATCCTGTGCCCAAAGACTATCGGAAAT GTTGCTTTTGTCATGAAGAAGGTGATGGATTGACAGATGGACCAGCAAGGC TACTCAACCTTGACTTGGATCTGTGGGTCCACTTGAACTGCGCTCTGTGGTC CACGGAGGTCTATGAGACTCAGGCTGGTGCCTTAATAAATGTGGAGCTAGC TCTGAGGAGAGGCCTACAAATGAAATGTGTCTTCTGTCACAAGACGGGTGC CACTAGTGGATGCCACAGATTTCGATGCACCAACATTTATCACTTCACTTGC GCCATTAAAGCACAATGCATGTTTTTTAAGGACAAAACTATGCTTTGCCCCA TGCACAAACCAAAGGGAATTCATGAGCAAGAATTAAGTTACTTTGCAGTCT TCAGGAGGGTCTATGTTCAGCGTGATGAGGTGCGACAGATTGCTAGCATCG TGCAACGAGGAGAACGGGACCATACCTTTCGCGTGGGTAGCCTCATCTTCC ACACAATTGGTCAGCTGCTTCCACAGCAGATGCAAGCATTCCATTCTCCTAA AGCACTCTTCCCTGTGGGCTATGAAGCCAGCCGGCTGTACTGGAGCACTCG CTATGCCAATAGGCGCTGCCGCTACCTGTGCTCCATTGAGGAGAAGGATGG GCGCCCAGTGTTTGTCATCAGGATTGTGGAACAAGGCCATGAAGACCTGGT TCTAAGTGACATCTCACCTAAAGGTGTCTGGGATAAGATTTTGGAGCCTGT GGCATGTGTGAGAAAAAAGTCTGAAATGCTCCAGCTTTTCCCAGCGTATTT AAAAGGAGAGGATCTGTTTGGCCTGACCGTCTCTGCAGTGGCACGCATAGC GGAATCACTTCCTGGGGTTGAGGCATGTGAAAATTATACCTTCCGATACGG CCGAAATCCTCTCATGGAACTTCCTCTTGCCGTTAACCCCACAGGTTGTGCC CGTTCTGAACCTAAAATGAGTGCCCATGTCAAGAGGTTTGTGTTAAGGCCT CACACCTTAAACAGCACCAGCACCTCAAAGTCATTTCAGAGCACAGTCACT GGAGAACTGAACGCACCTTATAGTAAACAGTTTGTTCACTCCAAGTCATCG CAGTACCGGAAGATGAAAACTGAATGGAAATCCAATGTGTATCTGGCACGG TCTCGGATTCAGGGGCTGGGCCTGTATGCTGCTCGAGACATTGAGAAACAC ACCATGGTCATTGAGTACATCGGGACTATCATTCGAAACGAAGTAGCCAAC AGGAAAGAGAAGCTTTATGAGTCTCAGAACCGTGGTGTGTACATGTTCCGC ATGGATAACGACCATGTGATTGACGCGACGCTCACAGGAGGGCCCGCAAG GTATATCAACCATTCGTGTGCACCTAATTGTGTGGCTGAAGTGGTGACTTTT GAGAGAGGACACAAAATTATCATCAGCTCCAGTCGGAGAATCCAGAAAGG AGAAGAGCTCTGCTATGACTATAAGTTTGACTTTGAAGATGACCAGCACAA GATTCCGTGTCACTGTGGAGCTGTGAACTGCCGGAAGTGGATGAACTGA CLTB-> ATGGCTGATGACTTTGGCTTCTTCTCGTCGTCGGAGAGCGGTGCCCCGGAG SEQ ID CDH 2 GCGGCGGAGGAGGACCCGGCGGCCGCCTTCCTGGCCCAGCAGGAGAGCGA NO:26 GATTGCAGGCATAGAGAACGACGAGGGCTTCGGGGCACCTGCCGGCAGCC ATGCGGCCCCCGCGCAGCCGGGCCCCACGAGTGGGGCTGGTTCTGAGGACA TGGGGACCACAGTCAATGGAGATGTGTTTCAGGTGCCCAGGCCTTCTGGTT GGTAGCGGAAGACCAGGACAATGACCCTCTGACCTATGGGATGAGCGGCC CCAATGCCTACTTCTTCGCTGTCACTCCGAAAACTGGGGAAGTGAAGCTGG CCAGCGCTCTGGACTACGAGACACTCTACACATTCAAAGTCACCATCTCCG TGAGCGACCCCTACATCCAGGTGCAGAGGGAGATGCTGGTGATTGTGGAAG ATAGAAACGACAACGCACCCGTTTTCCAGAACACCGCTTTCTCCACCAGCA TCAACGAGACCCTGCCCGTGGGCAGTGTGGTGTTCTCCGTGCTGGCCGTGG ATAAAGACATGGGGTCTGCAGGCATGGTCGTGTACTCCATAGAGAAGGTCA TCCCTAGCACTGGGGACAGCGAGCATCTCTTCCGGATCCTGGCCAATGGCT CCATAGTCCTCAATGGCAGCCTCAGCTACAACAACAAGAGCGCTTTCTACC AGCTGGAGCTGAAGGCCTGTGACTTGGGCGGCATGTACCACAACACCTTCA CCATCCAGTGCTCCCTGCCTGTCTTCCTGTCCATCTCCGTGGTGGACCAGCC TGACCTTGACCCCCAGTTTGTCAGGGAGTTTTACTCGGCCTCTGTGGCTGAG GATGCAGCCAAGGGAACCTCGGTGCTGACGGTGGAGGCTGTGGATGGCGA CAAAGGCATCAATGACCCTGTGATCTACAGCATCTCCTACTCCACGCGGCC CGGCTGGTTTGACATCGGGGCAGATGGGGTGATCAGGGTCAACGGCTCCCT GGACCGTGAGCAGCTGCTGGAGGCGGATGAGGAGGTGCAGCTGCAGGTCA CGGCCACCGAGACACACCTCAACATCTACGGGCAGGAGGCCAAGGTGAGC ATCTGGGTGACAGTGAGAGTGATGGACGTCAATGACCACAAACCTGAGTTT TACAACTGCAGCCTCCCAGCCTGCACCTTCACCCCCGAAGAGGCCCAAGTG AACTTCACTGGCTACGTGGACGAGCATGCCTCCCCCCGCATCCCCATCGAT GACCTCACCATGGTGGTCTACGACCCGGACAAGGGCAGCAATGGCACCTTC CTGTTGTCGCTGGGGGGCCCCGATGCAGAAGCCTTCAGCGTCTCCCCGGAG CGGGCAGTGGGCTCAGCCTCCGTTCAGGTGCTGGTGAGAGTATCCGCGCTG GTGGACTACGAGAGGCAGACGGCGATGGCGGTGCAGGTTGTGGCCACAGA CTCCGTCAGCCAGAACTTCTCCGTCGCCATGGTGACCATCCACCTTAGAGAC ATTAATGACCACAGGCCCACGTTTCCCCAGAGCTTGTACGTCCTCACGGTGC CAGAGCACAGCGCCACCGGCTCTGTGGTCACCGACAGCATCCACGCCACGG ACCCAGACACGGGCGCGTGGGGCCAAATTACCTACAGCCTGCTCCCAGGAA ATGGGGCAGACCTCTTCCAAGTGGATCCCGTCTCAGGGACGGTGACGGTGA GGAACGGTGAGCTGCTGGACCGGGAGAGCCAGGCCGTGTACTACCTGACG CTGCAGGCCACAGACGGCGGGAACCTGTCCTCCTCCACCACACTGCAGATC CACCTGCTGGACATCAACGACAATGCACCCGTGGTTAGCGGCTCCTACAAC ATCTTCGTCCAGGAGGAGGAGGGCAATGTCTCCGTGACCATCCAGGCCCAC GACAATGATGAGCCGGGCACCAACAACAGCCGTCTGCTCTTCAACCTGCTG CCTGGCCCCTACAGCCACAACTTCTCCTTGGACCCTGACACAGGGCTCCTCA GAAACCTGGGGCCCCTGGACAGAGAGGCCATCGACCCCGCCCTGGAGGGC CGCATTGTGCTGACAGTGCTTGTGTCTGACTGCGGCGAGCCTGTCCTCGGCA CCAAAGTCAATGTCACCATCACTGTGGAGGACATCAATGATAACCTGCCCA TCTTCAATCAGTCCAGCTACAACTTTACGGTGAAGGAGGAGGATCCAGGAG TGCTAGTGGGCGTGGTGAAGGCCTGGGACGCGGACCAGACGGAAGCCAAC AACCGCATCAGCTTCAGCCTGTCGGGGAGTGGTGCCAACTACTTCATGATC CGAGGCTTGGTGCTGGGGGCTGGGTGGGCTGAGGGCTACCTCCGGCTGCCC CCGGACGTGAGCCTGGATTACGAGACACAGCCCGTCTTCAACTTGACAGTG AGTGCTGAGAACCCAGACCCCCAGGGGGGTGAGACCATAGTAGACGTCTG CGTGAATGTGAAAGACGTGAACGACAATCCCCCCACCCTGGATGTAGCCTC ACTCCGGGGCATCCGTGTGGCTGAGAATGGCTCACAGCACGGCCAGGTGGC TGTGGTGGTTGCCTCGGATGTGGACACCAGTGCCCAGCTGGAGATACAGCT TGTGAACATTCTCTGCACCAAGGCCGGGGTCGATGTGGGCAGCCTATGCTG GGGCTGGTTCTCAGTGGCGGCCAACGGCTCTGTGTACATCAACCAGAGCAA AGCCATCGACTACGAGGCCTGTGACCTGGTCACGCTGGTTGTGCGGGCCTG TGACCTAGCCACGGACCCCGGCTTCCAGGCCTACAGCAACAATGGAAGCCT CCTCATTACCATTGAGGACGTGAATGACAATGCACCCTATTTTCTGCCTGAG AATAAGACTTTTGTGATCATCCCTGAACTCGTGCTGCCCAACCGGGAGGTG GCTTCTGTCCGGGCCAGAGACGATGATTCAGGGAACAATGGCGTCATCCTG TTCTCCATCCTCCGAGTAGACTTCATCTCTAAGGACGGGGCCACCATCCCTT TCCAGGGTGTCTTCTCGATCTTCACCTCCTCCGAGGCCGACGTGTTCGCTGG GAGCATTCAGCCGGTGACCAGCCTCGACTCCACTCTCCAAGGCACCTACCA AGTGACAGTCCAGGCCAGGGACAGACCTTCCTTGGGTCCTTTCCTGGAAGC CACCACCACCCTGAATCTCTTCACCGTGGACCAGAGTTACCGCTCGCGGCT GCAGTTCTCCACACCGAAGGAGGAGGTGGGCGCCAACAGACAGGCGATTA ATGCGGCTCTTACCCAGGCAACCAGGACTACAGTATACATTGTGGACATTC AGGACATAGATTCTGCAGCTCGGGCCCGACCTCACTCCTACCTCGATGCCT ACTTTGTCTTCCCCAATGGGTCAGCCCTGACCCTTGATGAGCTGAGTGTGAT GATCCGGAATGATCAGGACTCGCTGACGCAGCTGCTGCAGCTGGGGCTGGT GGTGCTGGGCTCCCAGGAGAGCCAGGAGTCAGACCTGTCGAAACAGCTCAT CAGTGTCATCATAGGATTGGGAGTGGCTTTGCTGCTGGTCCTTGTGATCATG ACCATGGCCTTCGTGTGTGTGCGGAAGAGCTACAACCGGAAGCTTCAAGCT ATGAAGGCTGCCAAGGAGGCCAGGAAGACAGCAGCAGGGGTGATGCCCTC AGCCCCTGCCATCCCAGGGACTAACATGTACAACACTGAGCGAGCCAACCC CATGCTGAACCTCCCCAACAAAGACCTGGGCTTGGAGTACCTCTCTCCCTCC AATGACCTGGACTCTGTCAGCGTCAACTCCCTGGACGACAACTCTGTGGAT GTGGACAAGAACAGTCAGGAAATCAAGGAGCACAGGCCACCACACACACC ACCAGAGCCAGATCCAGAGCCCCTGAGCGTGGTCCTGTTAGGACGGCAGGC AGGCGCAAGTGGACAGCTGGAGGGGCCATCCTACACCAACGCTGGCCTGG ACACCACGGACCTGTGA PDE4D-> ATGATGCACGTGAATAATTTTCCCTTTAGAAGGCATTCCTGGATATGTTTTG SEQ ID ITGA1 ATGTGGACAATGGCACATCTGCGGGACGGAGTCCCTTGGATCCCATGACCA NO:27 GCCCAGGATCCGGGCTAATTCTCCAAGCAAATTTTGTCCACAGTCAACGAC GGGAGTCCTTCCTGTATCGATCCGACAGCGATTATGACCTCTCTCCAAAGTC TATGTCCCGGAACTCCTCCATTGCCAGTGATATACACGGAGATGACTTGATT GTGACTCCATTTGCTCAGGTCTTGGCCAGTCTGCGAACTGTACGAAACAACT TTGCTGCATTAACTAATTTGCAAGATCGAGCACCTAGCAAAAGATCACCCA TGTGCAACCAACCATCCATCAACAAAGCCACCATAACAGAGGAGGCCTACC AGAAACTGGCCAGCGAGACCCTGGAGGAGCTGGACTGGTGTCTGGACCAG CTAGAGACCCTACAGACCAGGCACTCCGTCAGTGAGATGGCCTCCAACAAG TTTAAAAGGATGCTTAATCGGGAGCTCACCCATCTCTCTGAAATGAGTCGG TCTGGAAATCAAGTGTCAGAGTTTATATCAAACACATTCTTAGATAAGCAA CATGAAGTGGAAATTCCTTCTCCAACTCAGAAGGAAAAGGAGAAAAAGAA AAGACCAATGTCTCAGATCAGTGGAGTCAAGAAATTGATGCACAGCTCTAG TCTGACTAATTCAAGTATCCCAAGGTTTGGAGTTAAAACTGAACAAGAAGA TGTCCTTGCCAAGGAACTAGAAGATGTGAACAAATGGGGTCTTCATGTTTT CAGAATAGCAGAGTTGTCTGGTAACCGGCCCTTGACTGTTATCATGCACAC CATTTTTCAGGAACGGGATTTATTAAAAACATTTAAAATTCCAGTAGATACT TTAATTACATATCTTATGACTCTCGAAGACCATTACCATGCTGATGTGGCCT ATCACAACAATATCCATGCTGCAGATGTTGTCCAGTCTACTCATGTGCTATT ATCTACACCTGCTTTGGAGGCTGTGTTTACAGATTTGGAGATTCTTGCAGCA ATTTTTGCCAGTGCAATACATGATGTAGATCATCCTGGTGTGTCCAATCAAT TTCTGATCAATACAAGACAAGCATGACTTTCAGGACTCTGTGAGAATAACG TTGGACTTTAATCTTACCGATCCAGAAAATGGGCCTGTTCTTGATGATTCTC TACCAAACTCAGTACATGAATATATTCCCTTTGCCAAAGATTGTGGAAATA AGGAAAAATGTATCTCAGACCTCAGCCTGCATGTCGCCACCACTGAAAAGG ACCTGCTGATTGTCCGATCCCAGAATGATAAGTTCAACGTTAGCCTCACAGT CAAAAATACAAAGGACAGTGCCTATAACACCAGGACAATAGTGCATTATTC TCCAAATCTAGTTTTTTCAGGAATTGAGGCTATCCAAAAAGACAGTTGTGA ATCTAATCATAATATCACATGTAAAGTTGGATATCCCTTCCTGAGAAGAGG AGAGATGGTAACTTTCAAAATATTGTTTCAGTTTAACACATCCTATCTCATG GAAAATGTGACCATTTATTTAAGTGCAACAAGTGACAGCGAAGAACCTCCT GAAACCCTTTCTGATAATGTAGTAAACATTTCTATCCCGGTAAAATATGAA GTTGGACTACAGTTTTACAGCTCTGCAAGTGAATACCACATTTCAATTGCTG CCAATGAGACAGTCCCTGAAGTTATTAATTCTACTGAGGACATTGGAAATG AAATTAATATCTTCTACTTGATTAGAAAAAGTGGATCTTTTCCAATGCCAGA GCTTAAGCTGTCAATTTCATTCCCCAATATGACATCAAATGGTTACCCTGTG CTGTACCCAACTGGATTGTCATCTTCTGAGAATGCAAACTGCAGACCCCAT ATCTTTGAGGATCCTTTCAGTATCAACTCTGGAAAGAAAATGACTACATCA ACTGACCATCTCAAACGAGGCACAATTCTGGACTGCAATACATGTAAATTT GCTACCATCACATGTAATCTCACTTCTTCTGACATCAGCCAAGTCAATGTTT CGCTTATCTTGTGGAAACCAACTTTTATAAAATCATATTTTTCCAGCTTAAA TCTTACTATAAGGGGAGAACTTCGGAGTGAAAATGCATCTCTGGTTTTAAG TAGCAGCAATCAAAAAAGAGAGCTTGCTATTCAAATATCCAAAGATGGGCT ACCGGGCAGAGTGCCATTATGGGTCATCCTGCTGAGTGCTTTTGCCGGATTG TTGCTGTTAATGCTGCTCATTTTAGCACTGTGGAAGATTGGATTCTTCAAAA GACCACTGAAAAAGAAAATGGAGAAATGA DIP2B-> ATGGCGGAACGAGGCCTGGAGCCGTCGCCGGCCGCGGTGGCGGCGCTGCC SEQ ID LINC0033 GCCTGAAGTGCGGGCGCAGCTGGCGGAGCTGGAGCTGGAGCTCTCGGAGG NO:28 0 GGGACATCACCCAGAAGGGCTATGAAAAGAAAAGGTCCAAACTCCTATCTC CTTACAGCCCGCAGACACAAGAAACTGATTCAGCAGTACAGAAAGAACTTA GAAACCAGACACCTGCTCCATCTGCAGCTCAAACTTCTGCTCCCTCTAAGTA CCACCGAACTCGATCTGGGGGAGCCAGGGATGAACGATATCGATCAGAGTC TTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGACCTTGGCTCACTGGTT TGGGGCATGTTCCTGGGTGTGTCTGTGAGGAGCAAGAAAGCCAGTTCAAGT CCCAAAACCTCAAAAGTAGGGAAGCCGACAGGGCAGCCTTAAGTCTGTGG CTGAAGGCCTGAGAGACCCTGGCAAATCACTGATATAAGTCCAAAAGCTGA AGAACTTGGAATCTGATGTTGGAATCTGATCTTGGCCCATCCTTGAAGAATC TGGGGGTAATAAATACCCTGAACATTGATGAACCCAAAGGGAAGCCAGAA GGTCAGATGTCAGCTGTCGGGAAGAAAGGCTGGATAGGAAATAGGAAAAA GCAGGGCAAACAAGGAGCTTCAAGGACTGAAACCCTTAAGAACCACTTGA CTCTGTCTCTCACCACCTCCAGCCTTGATGACACGGTGACATATAGAAGAA CTGATGCCCTTTGCTTTGAGCTGCACAAAAACCTGGCGCTGGACTTGGAGA AGCTGAAAGACAGGACCCGGCAGGAGCCTGAGGAGCTGCAGGCTGCTAGC CTGTAGACCACCGTGCTGTGTTAGCCACTGCAGCTGGGACCATTCTGACACT CAGAGCCTGGAAATGGCTGCTCCCTCCTGCCTGCTATCCAAGTATCCTGTGG ATACTTGGCTTTTCTCTTGTGGGCAACACTAACCTGAAACTCTTTGGGGAAG GGAATTGAGGAAATGTAGTTCCAAGATTAGCCAATTTAACTCAGCATAAAC CCATCACAGGGTTTGACTACAGAGTTATAACGTTATTCTGTAGGCAATGAA AACAGAAGTTTTTGAAAAAGGCATCAATTTGATGAAATTGATATTTTGGGG AAGATTAATCTTCTGCTGAGTAAAATATAACAGGTTGGAGGAAGATGAAAA TGGAGAGAGTAGAGTGTAATTAAAAGTTTGTTGGAGGCCGGGCACGGGATT ACGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCGGATC ACCTGAGGTCAGGAGCTTGAGATCATCCCGGCCAACATAGTGAAACCCTGT CTCTAATAAAAATACGAAAAATTAGCTGGGCATGGTGGCGCACACCTGTAA TCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTGAACCCAGGAGGC AGAGGTTGCAATGAGCCAAGATGGTGTGATTGCACTCCAGCCCAGGGGACA ATGTGAGACTCTGTCTCAAAAAAAAAAAAAAATTTGTTGTAGTAGTCCAGG TGTCCGGGTGTTGTTACCAGGGCACCCATGATGAAATAACTGGGAGAGTCC TTTTTTCTGACTGGTTTTCTTCAGTCCCTTTATCTACAGGCACAACTGCTGAA GAAACCAGATGGCCTGGGATGGCACCAGAGCTTTTTTACCCTTGACCAGAT ACTAGAGGGAATTAAGACCCCACAAGTGGGCACGAACTGGAACTGGCGAC CCCTAGTTGCCTTCAGATCATTAACACATCATTATAATGCTAAAATTCCCTG CCATTTTGTGAACATGGGTTGCATGAAGACGTAAGTTTATGAATTGCCTCTG CACACCTAGAGTCCCACCCTGTACAGGCTAACATTCCTCCCTACATGCACCC CCCCACAAACACACCCTGCCTCCCCCAGTCCTTAGAAACCCTATGCCTGGC CGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCG GGCGGATCACTAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAA ACCCTGTCTTTACTAAAAATC PQLCl-> ATGGAGGCCGAGGGCCTGGACTGGCTCCTGGTGCCACTGCACCAGCTGGTG SEQ ID LINC0033 TCCTGGGGCGCGGCCGCGGCCATGGTCTTCGGAGGGGTGGTGCCCTACGTC NO:29 0 CCGCAGTATCGGGACATTCGCAGGACGCAGAACGCCGACGGCTTCTCCACC TACGTGTGCCTGGTGCTGCTGGTGGCCAACATTTTGCGGATACTCTTCTGAG TCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCGACCTTGGCTCACTGG TTTGGGGCATGTTCCTGGGTGTGTCTGTGAGGAGCAAGAAAGCCAGTTCAA GTCCCAAAACCTCAAAAGTAGGGAAGCCGACAGGGCAGCCTTAAGTCTGTG GCTGAAGGCCTGAGAGACCCTGGCAAATCACTGATATAAGTCCAAAAGCTG AAGAACTTGGAATCTGATGTTGGAATCTGATCTTGGCCCATCCTTGAAGAA TCTGGGGGTAATAAATACCCTGAACATTGATGAACCCAAAGGGAAGCCAG AAGGTCAGATGTCAGCTGTCGGGAAGAAAGGCTGGATAGGAAATAGGAAA AAGCAGGGCAAACAAGGAGCTTCAAGGACTGAAACCCTTAAGAACCACTT GACTCTGTCTCTCACCACCTCCAGCCTTGATGACACGGTGACATATAGAAG AACTGATGCCCTTTGCTTTGAGCTGCACAAAAACCTGGCGCTGGACTTGGA GAAGCTGAAAGACAGGACCCGGCAGGAGCCTGAGGAGCTGCAGGCTGCTA GCCTGTAGACCACCGTGCTGTGTTAGCCACTGCAGCTGGGACCATTCTGAC ACTCAGAGCCTGGAAATGGCTGCTCCCTCCTGCCTGCTATCCAAGTATCCTG TGGATACTTGGCTTTTCTCTTGTGGGCAACACTAACCTGAAACTCTTTGGGG AAGGGAATTGAGGAAATGTAGTTCCAAGATTAGCCAATTTAACTCAGCATA AACCCATCACAGGGTTTGACTACAGAGTTATAACGTTATTCTGTAGGCAAT GAAAACAGAAGTTTTTGAAAAAGGCATCAATTTGATGAAATTGATATTTTG GGGAAGATTAATCTTCTGCTGAGTAAAATATAACAGGTTGGAGGAAGATGA AAATGGAGAGAGTAGAGTGTAATTAAAAGTTTGTTGGAGGCCGGGCACGG GATTACGGCTCACTCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCG GATCACCTGAGGTCAGGAGCTTGAGATCATCCCGGCCAACATAGTGAAACC CTGTCTCTAATAAAAATACGAAAAATTAGCTGGGCATGGTGGCGCACACCT GTAATCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATCCCTTGAACCCAGG AGGCAGAGGTTGCAATGAGCCAAGATGGTGTGATTGCACTCCAGCCCAGGG GACAATGTGAGACTCTGTCTCAAAAAAAAAAAAAAATTTGTTGTAGTAGTC CAGGTGTCCGGGTGTTGTTACCAGGGCACCCATGATGAAATAACTGGGAGA GTCCTTTTTTCTGACTGGTTTTCTTCAGTCCCTTTATCTACAGGCACAACTGC TGAAGAAACCAGATGGCCTGGGATGGCACCAGAGCTTTTTTACCCTTGACC AGATACTAGAGGGAATTAAGACCCCACAAGTGGGCACGAACTGGAACTGG CGACCCCTAGTTGCCTTCAGATCATTAACACATCATTATAATGCTAAAATTC CCTGCCATTTTGTGAACATGGGTTGCATGAAGACGTAAGTTTATGAATTGCC TCTGCACACCTAGAGTCCCACCCTGTACAGGCTAACATTCCTCCCTACATGC ACCCCCCCACAAACACACCCTGCCTCCCCCAGTCCTTAGAAACCCTATGCCT GGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAG GCGGGCGGATCACTAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTG AAACCCTGTCTTTACTAAAAATC RABEP1- ATGGCGCAGCCGGGCCCGGCTTCCCAGCCTGACGTTTCTCTTCAGCAACGG SEQ ID > GTAGCAGAATTGGAAAAAATTAATGCAGAATTTTTACGTGCACAACAGCAG NO:30 DNAH9 CTTGAACAAGAATTTAATCAAAAGAGAGCAAAATTTAAGGAGTTATATTTG GCTAAAGAGGAGGATCTGAAGAGGCAAAATGCAGTATTACAAGCTGCACA AGATGATTTGGGACACCTTCGAACCCAGCTGTGGGAAGCTCAAGCAGAGAT GGAGAATATTAAGGCGATTGCCACAGTCTCTGAGAACACCAAGCAAGAAG CTATAGATGAAGTGAAAAGACAGTGGAGAGAAGAAGTTGCTTCACTTCAG GCTGTTATGAAAGAAACAGTTCGTGACTATGAGCACCAGTTCCACCTTAGG CTGGAGCAGGAGCGAACACAGTGGGCACAGTATAGAGAATCCGCAGAGAG GGAAATAGCTGATTTAAGAAGAAGGCTGTCTGAAGGTCAAGAGGAGGAAA ATTTAGAAAATGAAATGAAAAAGGCCCAAGAGGATGCTGAGAAACTTCGG TCCGTTGTGATGCCAATGGAAAAGGAAATTGCAGCTTTGAAGGATAAACTG ACAGAGGCTGAAGACAAAATTAAAGAGCTGGAGGCCTCAAAGGTTAAAGA ACTGAATCATTATCTGGAAGCTGAGAAATCTTGTAGGACTGATCTAGAGAT GTATGTAGCTGTTTTGAATACTCAGAAATCTGTTCTACAGGAAGATGCTGA GAAACTGCGGAAAGAATTGCATGAAGGGTCTTCTGAAGACGGCCCTGGATT TCCACAAACTGGGAAAGGTGGAGTTCAGCGGCGTCAGAGGGAATGCTCTG AGTCAGCAGGTCCAGCAAATGCATGAAGAATTTCAAGAGATGTACAGGCTT CTCTCAGGATCCTCCTCCGACTGCCTGTACCTCCAAAGCACGGACTTTGAAA ATGACGTCTCTGAATTTAACCAGAAAGTAGAAGATCTTGACCGAAGATTGG GGACTATCTTTATTCAAGCTTTTGATGATGCACCTGGCTTGGAGCATGCCTT TAAGCTGCTAGACATAGCAGGAAACCTCCTTGAAAGACCGCTGGTAGCGAG GGATACATCTGATAAATACCTGGTCCTCATCCAAATGTTCAACAAAGATCT GGATGCAGTGAGGATGATCTACAGTCAGCACGTCCAGGAGGAAGCAGAAC TTGGGTTCTCCCCGGTGCACAAGAACATGCCCACCGTGGCTGGCGGCCTCC GCTGGGCACAGGAGCTGAGGCAGCGCATCCAGGGTCCTTTCAGCAACTTTG GACGCATCACACACCCTTGCATGGAATCTGCAGAAGGAAAGCGAATGCAA CAAAAATATGAAGATATGCTGTCATTGCTAGAAAAGTATGAGACAAGACTT TATGAGGATTGGTGCCGGACAGTATCAGAGAAGTCACAGTACAATCTTTCC CAACCACTTCTAAAACGTGACCCAGAGACGAAGGAGATCACTATCAACTTT AACCCACAGCTGATTTCAGTGCTGAAAGAAATGAGCTATCTTGAACCCAGA GAGATGAAACACATGCCTGAGACAGCAGCAGCCATGTTCTCCTCCAGGGAT TTCTATCGGCAGCTTGTGGCTAATTTAGAGTTGATGGCAAATTGGTACAACA AGGTTATGAAAACTCTGCTGGAGGTGGAATTTCCATTAGTGGAGGAAGAGC TGCAAAATATTGATCTCCGCCTCAGAGCAGCAGAGGAGACTTTGAACTGGA AAACAGAAGGCATTTGCGATTATGTCACTGAAATCACCAGTAGTATTCATG ATCTTGAACAAAGAATTCAGAAAACTAAAGACAATGTGGAAGAGATCCAA AACATCATGAAAACATGGGTGACTCCAATATTTAAGACAAAAGATGGAAA AAGGGAATCCCTTCTTTCTCTGGATGATCGGCATGATCGAATGGAAAAATA TTACAATCTCATCAAGGAATCTGGCCTTAAGATCCACGCCCTTGTTCAGGAA AACCTGGGTCTATTTTCAGCAGACCCAACCTCCAATATCTGGAAGACTTATG TTAACTCTATTGACAATTTGTTGCTGAATGGATTCTTTCTTGCCATTGAGTGC TCCCTCAAGTATCTTCTGGAAAATACTGAGTGTAAGGCAGGACTTACCCCA ATATTTGAAGCACAACTGAGTCTAGCCATCCCAGAGCTAGTTTTCTATCCGT CTCTGGAGTCTGGAGTGAAGGGGGGTTTCTGTGACATTGTTGAGGGTCTCA TCACCAGCATTTTTAGGATACCATCTCTGGTGCCACGGCTTTCCCCACAAAA TGGCTCTCCTCACTATCAGGTCGACCTGGACGGTATACCAGATTTGGCAAA CATGCGGCGCACACTCATGGAGAGAGTCCAGAGAATGATGGGCCTCTGCTG TGGCTATCAGAGCACCTTCAGCCAGTATTCGTACCTCTATGTGGAGGACCG GAAGGAGGTTCTGGGTCAGTTTCTGCTGTACGGGCACATCCTCACTCCGGA AGAAATTGAAGACCATGTGGAAGATGGCATCCCAGAGAACCCTCCCCTCCT TTCTCAGTTTAAAGTGCAAATCGACTCCTATGAAACGCTCTATGAAGAGGT GTGCAGGCTGGAACCCATCAAGGTGTTTGACGGCTGGATGAAAATTGATAT TCGACCCTTTAAGGCATCTCTGCTGAATATTATTAAGAGGTGGAGCCTCCTG TTCAAACAGCATCTTGTGGACCACGTCACTCACAGCTTGGCCAACCTGGAT GCGTTTATAAAGAAGAGTGAGAGCGGCTTACTCAAGAAAGTTGAAAAAGG AGATTTCCAAGGCTTGGTTGAGATCATGGGACACCTTATGGCTGTTAAAGA ACGGCAGAGTAACACTGATGAGATGTTTGAGCCCTTAAAGCAGACTATTGA ATTGCTGAAGACCTATGAACAAGAATTGCCAGAAACAGTGTTTAAGCAGCT GGAGGAGCTGCCTGAGAAATGGAACAACATAAAAAAGGTGGCCATTACTG TGAAGCAGCAGGTGGCCCCACTGCAGGCAAATGAAGTGACACTCCTCCGCC AGAGGTGCACAGCCTTCGATGCAGAACAGCAGCAATTCTGGGAGCAATTCC ACAAAGAAGCCCCGTTCAGGTTTGATAGCATCCACCCTCATCAAATGCTGG ATGCCAGGCACATCGAGATCCAGCAGATGGAATCCACTATGGCCTCCATTT CTGAGTCTGCCAGCTTATTTGAAGTCAATGTCCCTGACTATAAGCAGCTGAG GCAGTGCAGGAAGGAGGTCTGCCAGCTGAAGGAGCTCTGGGACACCATTG GAATGGTGACCTCCAGCATCCATGCCTGGGAGACCACACCCTGGAGGAATA TCAACGTGGAAGCCATGGAGTTGGAGTGCAAACAGTTTGCCCGGCATATCC GAAACCTGGACAAGGAGGTCAGGGCCTGGGATGCATTCACAGGCCTGGAA AGCACTGTGTGGAACACGCTGAGCTCCCTGAGGGCAGTAGCTGAGCTGCAG AATCCAGCCATCCGGGAGCGGCACTGGAGGCAGCTGATGCAGGCCACCGG TGTGAGCTTCACTATGGACCAGGACACCACCCTAGCGCACCTGCTGCAGCT CCAGCTGCACCACTATGAGGATGAGGTCCGGGGCATTGTGGACAAAGCTGC AAAAGAGATGGGTATGGAGAAAACCTTAAAGGAGCTGCAGACTACCTGGG CTGGCATGGAATTCCAGTATGAGCCCCACCCACGGACCAATGTCCCCCTCC TGTGCTCTGATGAGGACCTCATAGAGGTTCTGGAGGATAATCAAGTTCAAC TTCAGAACCTGGTGATGTCCAAGTATGTTGCTTTCTTCTTGGAGGAGGTGTC GGGCTGGCAGAAGAAGCTGTCCACAGTGGACGCTGTCATCTCTATCTGGTT TGAAGTGCAGCGAACATGGACTCACCTGGAAAGCATATTCACTGGATCTGA AGATATTCGGGCACAGCTACCCCAGGATTCTAAAAGGTTTGAAGGCATCGA CATTGACTTTAAAGAGCTAGCTTATGATGCCCAGAAAATTCCAAATGTAGT GCAAACCACCAACAAGCCAGGCCTGTATGAAAAGCTGGAGGATATTCAGG GCAGATTGTGCCTGTGTGAGAAGGCCCTGGCAGAGTACCTCGACACCAAGA GGCTTGCCTTCCCGCGGTTTTACTTTCTCTCCTCCTCCGATCTGTTAGACATC CTTTCCAACGGCACAGCTCCACAACAGGTTCAACGTCACCTTTCCAAACTCT TTGACAACATGGCCAAGATGCGATTCCAGCTAGATGCCAGTGGGGAACCAA CCAAGACAAGCCTCGGCATGTACAGCAAAGAAGAGGAGTATGTGGCTTTCA GTGAGCCCTGTGACTGCAGCGGGCAGGTAGAAATATGGCTGAACCATGTCC TTGGTCACATGAAGGCCACTGTGAGGCATGAGATGACAGAAGGTGTAACTG CCTATGAAGAAAAGCCGAGGGAGCAGTGGCTTTTTGACCACCCAGCTCAGG TGGCCCTGACCTGTACTCAGATCTGGTGGACAACAGAAGTGGGCATGGCAT TTGCCAGGCTGGAGGAAGGCTATGAGAGTGCCATGAAGGACTATTATAAGA AGCAAGTGGCCCAGCTCAAAACCCTTATCACCATGCTGATTGGCCAGCTCT CCAAGGGAGACCGGCAGAAGATTATGACTATATGCACCATCGATGTGCATG CCCGGGATGTGGTAGCCAAGATGATTGCTCAGAAGGTAGACAATGCCCAGG CTTTCCTCTGGCTGTCTCAGCTGCGCCATCGTTGGGATGACGAGGTCAAACA CTGCTTTGCCAACATCTGTGATGCCCAGTTTTTGTATTCCTATGAGTACCTG GGAAACACACCTCGCTTGGTGATCACACCTTTGACTGACAGGTGCTACATC ACCCTCACCCAGTCCCTGCACCTGACCATGAGTGGGGCTCCCGCAGGACCT GCAGGCACAGGCAAGACCGAGACCACCAAGGACCTGGGCCGCGCACTGGG CATCCTGGTCTATGTGTTCAACTGCTCGGAGCAGATGGATTACAAGTCTTGT GGCAACATCTACAAAGGCCTTGCTCAGACTGGTGCCTGGGGCTGCTTTGAT GAGTTTAATCGAATCTCCGTGGAGGTCTTGTCAGTGGTGGCAGTGCAGGTA AAAAGCATTCAAGATGCGATTAGAGATAAGAAGCAGTGGTTCAGCTTCCTT GGGGAGGAGATCAGCCTGAATCCTTCTGTCGGTATCTTCATCACCATGAAC CCAGGCTATGCTGGCCGCACAGAGCTGCCAGAGAATCTCAAGTCTCTCTTC AGGCCTTGTGCAATGGTGGTTCCAGACTTTGAATTGATCTGTGAAATCATGC TGGTGGCAGAAGGATTCATTGAAGCCCAGTCATTAGCCAGAAAGTTCATCA CTCTTTACCAGTTGTGCAAAGAGCTTCTCTCCAAACAGGATCACTACGACTG GGGCCTACGGGCCATCAAGTCCGTGCTGGTGGTGGCAGGATCCCTGAAGAG AGGAGACCCTGACCGGCCTGAGGACCAGGTCCTGATGCGCTCCTTGCGGGA TTTCAACATCCCCAAGATTGTGACTGATGACATGCCCATCTTCATGGGCCTG ATCGGGGACCTCTTTCCCGCCCTGGATGTCCCCCGGAGGAGAGACCCCAAC TTCGAAGCTTTGGTTAGGAAGGCGATAGTGGATCTGAAGCTCCAGGCTGAG GACAACTTTGTGCTCAAGGTGGTCCAGCTGGAGGAGCTCCTGGCTGTGCGG CACTCTGTATTTGTGGTGGGTGGCGCTGGTACCGGCAAGTCACAGGTGCTG AGGTCCTTGCACAAGACCTATCAGATCATGAAACGGCGCCCCGTCTGGACT GACCTCAATCCCAAAGCAGTCACAAATGATGAGCTCTTTGGCATCATCAAT CCAGCCACAGGAGAATGGAAGGATGGATTGTTCTCTTCCATCATGCGGGAG CTTGCCAACATCACCCATGATGGGCCCAAGTGGATTTTACTGGATGGCGAC ATAGATCCAATGTGGATTGAATCCCTGAATACTGTCATGGATGATAACAAG GTGCTGACATTGGCCAGCAATGAGAGGATTCCTCTGAACCCCACCATGAAG CTCCTCTTTGAGATCAGCCACCTGCGCACAGCCACTCCAGCAACTGTCTCTA GAGCAGGGATCTTGTACATCAACCCGGCAGACTTGGGATGGAACCCTCCAG TGAGCAGCTGGATTGAGAAGAGGGAAATCCAGACAGAGAGAGCCAACTTA ACCATTTTGTTCGACAAGTATCTTCCAACCTGCCTAGACACACTCAGAACCA GGTTTAAGAAGATCATTCCCATCCCAGAGCAGAGCATGGTTCAGATGGTGT GTCACCTTCTGGAATGTCTCCTGACCACGGAGGACATCCCTGCAGACTGCC CTAAGGAAATTTATGAGCATTATTTTGTGTTTGCTGCCATCTGGGCTTTCGG CGGAGCAATGGTCCAAGATCAGCTTGTGGACTACCGGGCAGAGTTCAGCAA ATGGTGGCTGACTGAGTTCAAAACAGTCAAGTTTCCTTCCCAAGGAACCAT CTTTGACTATTACATCGACCCAGAGACCAAGAAATTCGAGCCTTGGTCCAA GCTCGTCCCCCAGTTCGAATTTGACCCCGAGATGCCCTTGCAGGCGTGTTTG GTGCACACGAGTGAGACCATCCGTGTGTGCTACTTCATGGAGCGGTTGATG GCGCGGCAGCGGCCTGTCATGCTGGTGGGCACGGCTGGCACTGGCAAGTCG GTGCTGGTGGGAGCTAAGCTGGCCAGCCTTGACCCCGAGGCATACCTGGTG AAAAACGTGCCATTCAACTACTACACCACGTCAGCAATGCTGCAGGCTGTC CTGGAGAAGCCTCTGGAAAAGAAGGCTGGCAGAAACTATGGCCCTCCAGG GAACAAGAAACTCATCTATTTCATTGATGACATGAACATGCCTGAGGTGGA TGCCTACGGGACGGTGCAGCCCCACACCATCATCCGGCAGCATCTGGACTA TGGCCACTGGTATGATCGGAGCAAGCTGTCCCTAAAGGAGATCACAAATGT ACAGTATGTTTCCTGTATGAACCCCACGGCAGGCAGCTTCACCATCAACCC CCGGCTTCAGCGTCACTTCAGCGTGTTTGTCCTCTCCTTCCCGGGGGCAGAT GCCCTGTCCTCTATCTACAGCATCATCCTCACTCAGCATCTGAAGCTCGGAA ACTTCCCGGCGTCCCTGCAGAAATCCATCCCCCCACTGATCGATCTGGCCCT CGCCTTCCACCAGAAAATTGCTACCACCTTCCTACCCACAGGAATCAAATTC CACTACATCTTCAACCTCAGAGATTTTGCCAACATTTTCCAGGGCATTCTCT TCTCCTCAGTGGAATGTGTGAAATCCACATGGGATCTTATAAGGCTCTATCT GCATGAATCAAATCGAGTTTATCGGGATAAGATGGTAGAAGAAAAGGACTT TGATCTTTTTGATAAAATCCAGACAGAAGTGCTCAAGAAAACTTTTGATGA TATTGAAGACCCTGTGGAGCAGACCCAAAGCCCGAACCTGTATTGTCACTT TGCAAATGGTATTGGGGAGCCCAAATACATGCCTGTACAGTCTTGGGAACT TTTGACCCAGACTCTGGTGGAGGCCTTGGAGAACCACAATGAAGTCAACAC AGTGATGGACCTAGTTCTCTTTGAGGATGCCATGCGCCATGTCTGCCATATC AATCGCATCTTGGAGTCCCCGCGGGGAAATGCTCTGCTGGTTGGTGTAGGT GGGAGCGGCAAGCAGAGCCTGACAAGGCTGGCAGCTTTCATCAGCTCCATG GATGTCTTCCAGATCACACTGCGCAAAGGCTACCAGATCCAGGACTTCAAG ATGGACCTGGCCAGCCTGTGTCTGAAAGCTGGAGTGAAGAATCTCAACACA GTGTTTCTCATGACTGATGCCCAAGTGGCTGATGAGAGGTTCCTTGTGCTCA TCAATGATCTTTTGGCATCTGGGGAGATCCCAGATCTCTACTCTGATGATGA AGTTGAAAACATCATAAGCAATGTGAGGAATGAAGTCAAGAGCCAGGGTC TGGTTGACAACAGAGAGAACTGTTGGAAGTTCTTTATAGATCGGATCCGGC GACAGCTGAAGGTGACTCTCTGTTTCTCCCCTGTGGGAAACAAGCTAAGAG TCCGCAGCAGGAAGTTCCCAGCCATTGTGAACTGCACAGCCATCCACTGGT TCCACGAGTGGCCTCAGCAAGCATTGGAGTCTGTCAGCCTCCGCTTCTTGCA GAACACAGAGGGCATTGAGCCCACAGTAAAGCAGTCGATTAGCAAATTCAT GGCCTTTGTCCACACAAGTGTCAACCAAACATCCCAGTCTTATCTGAGCAAT GAACAGCGCTACAACTATACAACTCCCAAGTCCTTTCTGGAGTTCATCAGA CTCTACCAGAGCTTGTTGCACAGGCACAGAAAAGAGCTCAAGTGCAAGACA GAGCGGTTGGAGAACGGGCTGCTGAAGCTGCATAGCACCTCTGCCCAGGTG GATGATCTGAAAGCAAAGCTGGCTGCCCAGGAAGTAGAGCTGAAGCAGAA AAATGAAGATGCAGACAAACTGATTCAGGTCGTGGGTGTGGAGACTGACA AAGTGAGCAGAGAGAAAGCCATGGCAGATGAAGAGGAGCAGAAGGTGGC CGTCATCATGCTAGAGGTGAAACAGAAGCAGAAGGACTGTGAGGAGGACC TGGCAAAGGCTGAGCCAGCACTCACAGCAGCGCAGGCAGCTCTCAACACC CTGAACAAGACCAACCTGACAGAGCTGAAGTCATTTGGCTCTCCGCCTCTG GCCGTCAGCAATGTCAGCGCTGCGGTGATGGTACTGATGGCTCCCAGGGGT AGGGTGCCCAAGGACCGGAGCTGGAAGGCTGCTAAGGTCACCATGGCCAA AGTGGATGGCTTCCTGGACTCGCTAATAAACTTCAACAAAGAGAACATTCA CGAGAACTGCCTCAAAGCCATCAGGCCGTATCTGCAAGACCCCGAGTTCAA TCCTGAGTTTGTGGCCACCAAATCCTATGCGGCTGCAGGCCTCTGCTCCTGG GTCATCAATATTGTGAGATTTTATGAGGTGTTCTGTGATGTGGAACCCAAGC GCCAGGCACTGAACAAAGCCACCGCGGACCTCACAGCTGCCCAGGAGAAG CTGGCTGCCATCAAAGCCAAGATCGCTCACCTTAATGAAAACCTGGCAAAG CTCACAGCCAGGTTTGAGAAAGCAACAGCAGACAAACTCAAATGTCAGCA AGAAGCCGAAGTGACCGCAGTCACCATCTCCCTTGCCAACCGCCTGGTTGG AGGACTCGCTTCTGAAAACGTGAGGTGGGCAGATGCCGTGCAGAACTTCAA ACAGCAGGAAAGGACGTTATGTGGAGACATTTTACTTATAACGGCTTTCAT TTCCTACCTTGGCTTCTTCACAAAGAAATACCGGCAGAGCCTCCTGGACAG AACTTGGAGGCCCTACCTGAGCCAGCTGAAAACTCCCATTCCAGTCACCCC AGCCCTGGATCCCCTGAGGATGCTGATGGATGATGCTGACGTGGCTGCCTG GCAGAACGAGGGCCTCCCAGCCGACCGCATGTCCGTGGAGAATGCCACCAT TCTCATCAACTGTGAGCGCTGGCCACTCATGGTTGACCCTCAGCTACAAGG CATCAAATGGATCAAGAATAAATATGGTGAAGATCTCCGGGTCACGCAGAT TGGTCAGAAAGGCTACCTTCAAATCATAGAGCAGGCCCTGGAAGCTGGAGC TGTGGTGCTGATTGAAAATCTAGAGGAGTCCATTGATCCTGTTCTGGGACCC CTGCTTGGGAGAGAAGTCATTAAAAAAGGACGATTCATTAAAATTGGAGAC AAAGAATGTGAATACAATCCCAAGTTCCGGCTCATCCTCCACACCAAGCTG GCTAATCCTCACTACCAGCCTGAGCTGCAGGCTCAGGCCACCCTGATCAAC TTCACCGTGACCAGGGATGGCCTGGAGGACCAGTTGCTGGCCGCTGTGGTC AGCATGGAGAGGCCAGACTTGGAGCAGCTGAAGTCCGATCTCACAAAGCA GCAGAATGGATTCAAAATTACCCTGAAAACGTTGGAAGACAGTCTTCTCTC TCGCCTCTCCTCCGCCTCTGGGAACTTCCTGGGAGAAACAGTGCTGGTGGA AAACCTAGAGATCACCAAGCAGACTGCTGCCGAAGTTGAGAAAAAGGTCC AGGAGGCCAAGGTGACTGAAGTGAAAATCAACGAGGCCCGAGAGCACTAC CGGCCAGCAGCTGCCAGGGCCTCACTGCTCTACTTCATCATGAACGACCTC AGCAAGATCCATCCAATGTACCAGTTTTCTCTCAAGGCCTTCAGTATCGTCT TCCAGAAGGCTGTGGAGAGGGCTGCTCCTGACGAAAGCCTCAGGGAGCGG GTGGCCAACCTAATAGACAGCATAACCTTCTCTGTGTACCAGTACACCATC CGCGGGCTCTTTGAGTGTGATAAGCTGACCTACCTTGCCCAGCTCACCTTTC AGATTCTCCTCATGAACCGAGAAGTCAATGCAGTGGAGTTGGATTTCCTGC TTCGATCTCCAGTGCAGACGGGCACCGCCAGCCCCGTGGAGTTCCTCTCCC ATCAGGCGTGGGGAGCTGTCAAGGTACTTTCATCAATGGAAGAATTCTCTA ATCTGGATCGGGACATAGAGGGATCTGCTAAGAGCTGGAAAAAGTTTGTGG AGTCCGAATGTCCTGAGAAAGAGAAGCTCCCACAGGAGTGGAAGAACAAG ACAGCCCTGCAGCGCCTCTGCATGCTGAGAGCCATGCGGCCCGACCGGATG ACCTATGCTTTGCGAGATTTTGTTGAAGAGAAGTTAGGAAGCAAATACGTG GTGGGAAGAGCCCTAGATTTTGCAACCTCATTTGAAGAATCGGGACCAGCC ACTCCTATGTTTTTCATCCTGTCTCCAGGGGTGGACCCACTGAAGGATGTAG AAAGTCAAGGAAGAAAACTTGGATACACCTTCAACAATCAGAACTTTCACA ACGTGTCTTTGGGGCAAGGACAGGAAGTGGTGGCTGAGGCTGCGCTGGACC TCGCTGCCAAGAAAGGTCACTGGGTTATTTTGCAGAACATTCACCTGGTGG CCAAGTGGCTCAGCACCCTGGAGAAGAAGCTGGAGGAGCACAGTGAGAAC AGCCACCCAGAGTTCAGGGTCTTCATGAGTGCAGAGCCAGCACCCTCCCCT GAGGGCCACATCATCCCCCAGGGCATCCTGGAGAACTCCATTAAGATCACC AATGAGCCCCCCACGGGCATGCATGCCAACCTGCACAAGGCCCTGGACAAC TTCACTCAGGACACTCTGGAGATGTGTTCTCGGGAGACGGAGTTTAAGAGC ATCCTCTTTGCTCTTTGTTACTTCCATGCGGTGGTGGCAGAAAGACGAAAAT TTGGGCCCCAGGGATGGAATCGCTCATACCCCTTTAACACTGGAGACCTCA CTATCTCTGTGAATGTCCTCTACAACTTCCTGGAGGCCAACGCAAAGGTCCC CTATGATGATTTGCGCTACCTGTTTGGAGAGATCATGTATGGAGGCCATATC ACAGATGACTGGGACAGAAGACTCTGCAGAACCTACCTGGGGGAATTCATT CGACCAGAAATGTTAGAAGGAGAACTGTCTTTGGCCCCAGGGTTCCCACTC CCAGGCAACATGGACTACAATGGTTATCATCAGTACATCGATGCTGAGCTG CCCCCAGAATCCCCCTACCTCTATGGCCTCCACCCGAACGCAGAGATTGGC TTCCTGACCCAAACCTCAGAAAAGCTCTTCCGCACTGTGCTGGAGCTGCAG CCTCGGGACAGCCAGGCCAGAGACGGAGCGGGCGCCACAAGAGAAGAAAA GGTCAAGGCACTTCTGGAAGAAATATTGGAGCGGGTGACAGACGAGTTTAA CATCCCAGAACTGATGGCCAAAGTGGAGGAGCGCACCCCTTACATTGTAGT TGCCTTCCAGGAGTGTGGCCGGATGAATATCCTCACCAGAGAGATTCAGCG CTCACTGAGGGAGCTGGAGCTCGGCTTAAAGGGGGAGCTGACTATGACCAG CCACATGGAGAACTTACAGAATGCCCTGTACTTCGATATGGTGCCAGAGTC CTGGGCTAGACGAGCCTACCCTTCCACAGCAGGCCTGGCAGCCTGGTTTCC AGACCTCCTCAACAGAATCAAGGAGCTAGAGGCTTGGACGGGTGACTTTAC AATGCCCTCCACTGTGTGGCTGACAGGCTTCTTCAACCCCCAGTCGTTCCTG ACTGCCATCATGCAGTCCACGGCTCGCAAGAATGAGTGGCCACTGGACCAG ATGGCCCTGCAATGTGACATGACGAAGAAGAACAGAGAAGAGTTTAGGAG TCCTCCTCGGGAAGGGGCCTACATCCATGGCCTCTTCATGGAAGGTGCCTG CTGGGACACACAGGCTGGGATCATTACAGAGGCAAAGCTGAAGGATCTGA CACCCCCTATGCCTGTGATGTTCATCAAGGCCATTCCTGCAGATAAGCAGG ACTGCCGCAGTGTCTATTCCTGTCCTGTGTACAAGACTAGTCAGCGGGGAC CCACCTACGTGTGGACTTTCAACCTGAAGACTAAGGAAAACCCATCCAAGT GGGTTCTGGCTGGAGTAGCCTTGCTTCTCCAGATTTAG C10orfl37 ATGGGGGATGCCAAGGAGGCCGGAGCCGAGGGTCCGCCGGCCGGGGCCGC SEQ ID -> CGCTCGAGGAGGGCTCAGCCTCCTGTCCCAGGGAGAATCCGAGGAATCTTC NO: 3 1 LOCI 001 TGCACAGGGATCAGCTTTATTTCTTGGAGGCAATGAAGTGAAGAGCCGAGC 69752 TGTGGTGAAATACTCTTCTGCCCCTCCTCGAACAGCATTTGCACGCCTTGAA GAGAAAACAGACTTGAAACTCCCACCTGCCAACTGGTTACGAGAGAGTGCC AAACTAGGGCCAGCAGGAACTACCATTCTTGGCAACAGCAAGAAAAGCAA GCCATTTTCAAGCTTTGGCATGGCATATGACTTTATTGATTCAGTGGGAAAT GATGTGGATGTTGTCTCTGACTCTGAAGTGAGGAGAAGATGCTGTTCTGAG AGCTGCTGATAATACGTGGATCCAAACCCACAGGCTTGAGCTGCTTAATTG AAATTCACGTCAAAATGAAATTCTGGTTTAGCTCAACTTGACTACTATGGAT GATGAAAATAAATCCCTGGGTCACACAAGGATAGTGATTGAGTAGAGCTTG TTTGCTGGCACAGGAATGACATTTCAACTGGAATTAAATTGTCGTCAGTTAA CAGAAC TFG-> ATGAACGGACAGTTGGATCTAAGTGGGAAGCTAATCATCAAAGCTCAACTT SEQ ID GPR128 GGGGAGGATATTCGGCGAATTCCTATTCATAATGAAGATATTACTTATGAT NO:32 GAATTAGTGCTAATGATGCAACGAGTTTTCAGAGGAAAACTTCTGAGTAAT GATGAAGTAACAATAAAGTATAAAGATGAAGATGGAGATCTTATAACAATT TTTGATAGTTCTGACCTTTCCTTTGCAATTCAGTGCAGTAGGATACTGAAAC TGACATTATTTGGAAAATCTACTTCCTCATCAAGCACCCCTACAGAGTTCTG CAGGAATGGTGGAACCTGGGAAAATGGCAGATGTATTTGTACAGAAGAGT GGAAAGGACTGAGATGTACAATTGCTAATTTTTGTGAAAATAGTACCTATA TGGGTTTTACTTTTGCCAGAATCCCAGTGGGCAGATATGGACCATCCTTGCA AACATGTGGCAAGGATACTCCAAATGCGGGCAATCCAATGGCAGTCCGGTT GTGCAGTCTCTCTCTATATGGAGAGATAGAATTACAAAAAGTGACAATAGG AAATTGCAATGAAAATCTGGAAACCCTGGAAAAGCAGGTAAAGGATGTCA CAGCACCACTTAATAACATTTCTTCTGAAGTCCAGATTTTAACATCTGATGC CAATAAATTAACTGCTGAGAACATCACTAGTGCTACGCGAGTGGTTGGACA GATATTCAACACTTCCAGAAATGCTTCACCTGAGGCAAAGAAAGTTGCCAT AGTAACAGTGAGTCAACTCCTAGATGCCAGTGAAGATGCTTTTCAAAGAGT TGCTGCTACTGCTAATGATGATGCCCTTACAACGCTTATTGAGCAAATGGA GACTTATTCCTTGTCTTTGGGTAATCAATCAGTGGTGGAACCTAACATAGCA ATACAGTCAGCAAATTTCTCTTCAGAAAATGCGGTGGGGCCTTCAAATGTT CGCTTCTCTGTGCAGAAAGGAGCTAGCAGTTCTCTAGTTTCTAGTTCAACAT TTATACATACAAATGTGGATGGCCTTAACCCAGATGCACAGACTGAGCTTC AGGTCTTGCTTAATATGACGAAAAATTACACCAAGACATGCGGCTTTGTAG TTTATCAAAATGACAAGCTTTTCCAATCAAAAACTTTTACAGCTAAATCGGA TTTTAGTCAAAAAATTATCTCAAGCAAAACTGATGAAAATGAGCAAGATCA GAGTGCTTCTGTTGACATGGTCTTTAGTCCAAAGTACAACCAAAAAGAATT TCAACTCTATTCCTATGCCTGTGTCTATTGGAATTTGTCAGCGAAGGACTGG GACACATATGGCTGTCAAAAAGACAAGGGCACTGATGGATTCCTGCGCTGC CGCTGCAACCATACTACTAATTTTGCTGTATTAATGACTTTCAAAAAGGATT ATCAATATCCCAAATCACTTGACATATTATCCAACGTTGGATGTGCACTGTC TGTTACTGGTCTGGCTCTCACAGTTATATTTCAGATTGTCACCAGGAAAGTC AGAAAAACCTCAGTAACCTGGGTTTTGGTCAATCTGTGCATATCAATGTTG ATTTTCAACCTCCTCTTTGTGTTTGGAATTGAAAACTCCAATAAGAACTTGC AGACAAGTGATGGTGACATCAATAATATTGACTTTGACAATAATGACATAC CCAGGACAGACACCATTAACATCCCGAATCCCATGTGCACTGCGATTGCCG CCTTACTGCACTATTTTCTGTTAGTGACATTTACCTGGAACGCACTCAGCGC TGCACAGCTCTATTACCTTCTAATAAGGACCATGAAGCCTCTTCCTCGGCAT TTCATTCTTTTCATCTCATTAATTGGATGGGGAGTCCCAGCTATAGTAGTGG CTATAACAGTGGGAGTTATTTATTCTCAGAATGGAAATAATCCACAGTGGG AATTAGACTACCGGCAAGAGAAAATCTGCTGGCTGGCAATTCCAGAACCCA ATGGTGTTATAAAAAGTCCGCTGTTGTGGTCATTCATCGTACCTGTAACCAT TATCCTCATCAGCAATGTTGTTATGTTTATTACAATCTCGATCAAAGTGCTG TGGAAGAATAACCAGAACCTGACAAGCACAAAAAAAGTTTCATCCATGAA GAAGATTGTTAGCACATTATCTGTTGCAGTTGTTTTTGGAATTACCTGGATT CTAGCATACCTGATGCTAGTTAATGATGATAGCATCAGGATCGTCTTCAGCT ACATATTCTGCCTTTTCAACACTACACAGGGATTGCAAATTTTTATCCTGTA CACTGTTAGAACAAAAGTCTTCCAGAGTGAAGCTTCCAAAGTGTTGATGTT GCTATCGTCTATTGGGAGAAGGAAGTCATTGCCTTCAGTGACGCGGCCGAG GCTGCGTGTAAAGATGTATAATTTCCTCAGGTCATTGCCAACCTTACATGAA CGCTTTAGGCTACTGGAAACCTCTCCGAGTACTGAGGAAATCACACTCTCT GAAAGTGACAATGCAAAGGAAAGCATCTAG LRP5-> ATGGAGGCAGCGCCGCCCGGGCCGCCGTGGCCGCTGCTGCTGCTGCTGCTG SEQ ID SLC22A2 CTGCTGCTGGCGCTGTGCGGCTGCCCGGCCCCCGCCGCGGCCTCGCCGCTC NO:33 4 CTGCTATTTGCCAACCGCCGGGACGTACGGCTGGTGGACGCCGGCGGAGTC AAGCTGGAGTCCACCATCGTGGTCAGCGGCCTGGAGGATGCGGCCGCAGTG GACTTCCAGTTTTCCAAGGGAGCCGTGTACTGGACAGACGTGAGCGAGGAG GCCATCAAGCAGACCTACCTGAACCAGACGGGGGCCGCCGTGCAGAACGT GGTCATCTCCGGCCTGGTCTCTCCCGACGGCCTCGCCTGCGACTGGGTGGGC AAGAAGCTGTACTGGACGGACTCAGAGACCAACCGCATCGAGGTGGCCAA CCTCAATGGCACATCCCGGAAGGTGCTCTTCTGGCAGGACCTTGACCAGCC GAGGGCCATCGCCTTGGACCCCGCTCACGGGTACATGTACTGGACAGACTG GGGTGAGACGCCCCGGATTGAGCGGGCAGGGATGGATGGCAGCACCCGGA AGATCATTGTGGACTCGGACATTTACTGGCCCAATGGACTGACCATCGACC TGGAGGAGCAGAAGCTCTACTGGGCTGACGCCAAGCTCAGCTTCATCCACC GTGCCAACCTGGACGGCTCGTTCCGGCAGAAGGTGGTGGAGGGCAGCCTGA CGCACCCCTTCGCCCTGACGCTCTCCGGGGACACTCTGTACTGGACAGACT GGCAGACCCGCTCCATCCATGCCTGCAACAAGCGCACTGGGGGGAAGAGG AAGGAGATCCTGAGTGCCCTCTACTCACCCATGGACATCCAGGTGCTGAGC CAGGAGCGGCAGCCTTTCTTCCACACTCGCTGTGAGGAGGACAATGGCGGC TGCTCCCACCTGTGCCTGCTGTCCCCAAGCGAGCCTTTCTACACATGCGCCT GCCCCACGGGTGTGCAGCTGCAGGACAACGGCAGGACGTGTAAGGCAGCT TGTGAGATCCACCATGAAGAAGGAGTTGGATGCAGTCCGAATTAAAACATC CATTTTTTCCCTGTTCCGTGCACCCAAATTGCGAATGAGAGTCTTCGGCCTG TGCTTTGTGAGATTCGCAATCACTGTACCCTTTTATGGCCTGATACTCAACT TGCAGCACTTAGGGAGCAATGTCTCCCTGTTCCAGATTCTCTGTGGAGCTGT CACATTCACAGCCAGATGTGTTTCCCTTTTGACACTGAATCATATGGGTCGT CGAATAAGCCAGATATTGTTCACGTTCCCGGTGGGACTTTTCATTCTGGTCA ACACCTTTTTGCCCCAAGAAATGCAGATCCTGCGTGTGGTTTTAGCAACTTT GGGAATTGGTAGTGTTTCTGCTGCTAGCAACAGTGCTTCTGTCCACCACAAC GAGCTCGTCCCCACCATATTGAGGTCAACAGTTGCAGGAATCAATGCAGTG TCCGGTAGGACTGGGGCAGCACTGGCTCCTCTGTTGATGACCTTAATGGCG TATTCTCCCCACCTACCCTGGATTTCCTATGGAGTCTTCCCCATCCTTGCTGT CCCTGTTATCCTCCTCCTTCCAGAAACCAGGGATCTACCTCTTCCTAACACC ATCCAGGATGTGGAAAATGACAGAAAAGATTCAAGAAACATAAAGCAGGA AGATACTTGCATGAAAGTAACACAGTTTTAA PPP2R2D AGCGGACATCATTTCCACCGTTGAGTTTAATTACTCTGGAGATCTTCTTGCA SEQ ID -> ACAGGAGACAAGGGCGGCAGAGTTGTTATTTTTCAGCGTGAACAAGAGAAT NO: 34 PANK1 AAAAGCCGCCCTCATTCTAGGGGAGAATATAATGTTTACAGCACCTTTCAA AGTCATGAACCGGAGTTTGACTATTTGAAAAGTCTAGAAATTGAGGAAAAA ATTAATAAAATTAGGTGGTTACCACAACAGAATGCTGCTCATTTTCTACTGT CTACAAATGATAAAACTATAAAATTATGGAAAATAAGTGAACGGGATAAA AGAGCAGAAGGTTATAACCTGAAAGACGAAGATGGAAGACTTCGAGACCC ATTTAGGATCACGGCGCTACGGGTCCCAATATTGAAGCCCATGGATCTTAT GGTAGAAGCGAGTCCACGGCGAATTTTTGCAAATGCTCACACATATCATAT AAATTCCATTTCAGTAAATAGTGATCATGAAACATATCTTTCTGCAGATGAC CTGAGAATTAATTTATGGCACTTAGAAATCACAGATAGAAGCTTTAACATC GTGGACATCAAGCCTGCTAACATGGAGGAGCTGACCGAAGTCATCACTGCA GCCGAGTTCCACCCGCACCAGTGCAACGTGTTCGTCTACAGCAGTAGCAAA GGGACCATCCGCCTGTGTGACATGCGCTCCTCGGCCCTGTGCGACAGACAC TCCAAGTTTTTTGAAGAGCCTGAAGATCCCAGCAGTAGGTCCTTCTTCTCAG AAATAATTTCATCCATATCCGATGTAAAATTCAGTCATAGTGGGCGGTACA TGATGACCAGAGACTACCTGTCGGTGAAGGTGTGGGACCTCAACATGGAGA GCAGGCCGGTGGAGACCCACCAGGTCCACGAGTACCTGCGCAGCAAGCTCT GCTCTCTCTATGAGAACGACTGCATCTTTGACAAGTTTGAGTGTTGCTGGAA CGGTTCGGATAGGGTTATTTTGGAGCCGTTGGGGCACTGTTGGAACTGTTCA AAATGACTGATGACAAGTAG IGFlR-> ATGAAGTCTGGCTCCGGAGGAGGGTCCCCGACCTCGCTGTGGGGGCTCCTG SEQ ID DCC TTTCTCTCCGCCGCGCTCTCGCTCTGGCCGACGAGTGGAGAAATCTGCGGGC NO:35 CAGGCATCGACATCCGCAACGACTATCAGCAGCTGAAGCGCCTGGAGAACT GCACGGTGATCGAGGGCTACCTCCACATCCTGCTCATCTCCAAGGCCGAGG ACTACCGCAGCTACCGCTTCCCCAAGCTCACGGTCATTACCGAGTACTTGCT GCTGTTCCGAGTGGCTGGCCTCGAGAGCCTCGGAGACCTCTTCCCCAACCTC ACGGTCATCCGCGGCTGGAAACTCTTCTACAACTACGCCCTGGTCATCTTCG AGATGACCAATCTCAAGGATATTGGGCTTTACAACCTGAGGAACATTACTC GGGGGGCCATCAGGATTGAGAAAAATGCTGACCTCTGTTACCTCTCCACTG TGGACTGGTCCCTGATCCTGGATGCGGTGTCCAATAACTACATTGTGGGGA ATAAGCCCCCAAAGGAATGTGGGGACCTGTGTCCAGGGACCATGGAGGAG AAGCCGATGTGTGAGAAGACCACCATCAACAATGAGTACAACTACCGCTGC TGGACCACAAACCGCTGCCAGAAAATGTGCCCAAGCACGTGTGGGAAGCG GGCGTGCACCGAGAACAATGAGTGCTGCCACCCCGAGTGCCTGGGCAGCTG CAGCGCGCCTGACAACGACACGGCCTGTGTAGCTTGCCGCCACTACTACTA TGCCGGTGTCTGTGTGCCTGCCTGCCCGCCCAACACCTACAGGTTTGAGGGC TGGCGCTGTGTGGACCGTGACTTCTGCGCCAACATCCTCAGCGCCGAGAGC AGCGACTCCGAGGGGTTTGTGATCCACGACGGCGAGTGCATGCAGGAGTGC CCCTCGGGCTTCATCCGCAACGGCAGCCAGAGCATGTACTGCATCCCTTGT GAAGGTCCTTGCCCGAAGGTCTGTGAGGAAGAAAAGAAAACAAAGACCAT TGATTCTGTTACTTCTGCTCAGATGCTCCAAGGATGCACCATCTTCAAGGGC AATTTGCTCATTAACATCCGACGGGGGAATAACATTGCTTCAGAGCTGGAG AACTTCATGGGGCTCATCGAGGTGGTGACGGGCTACGTGAAGATCCGCCAT TCTCATGCCTTGGTCTCCTTGTCCTTCCTAAAAAACCTTCGCCTCATCCTAGG AGAGGAGCAGCTAGAAGGGTTTTCAAATTAAAGCTTTCACAGCACTGCGCT TCCTCTCAGAACCTTCTGATGCCGTCACAATGCGGGGAGGAAATGTCCTCCT CGACTGCTCCGCGGAGTCCGACCGAGGAGTTCCAGTGATCAAGTGGAAGAA AGATGGCATTCATCTGGCCTTGGGAATGGATGAAAGGAAGCAGCAACTTTC AAATGGGTCTCTGCTGATACAAAACATACTTCATTCCAGACACCACAAGCC AGATGAGGGACTTTACCAATGTGAGGCATCTTTAGGAGATTCTGGCTCAAT TATTAGTCGGACAGCAAAAGTTGCAGTAGCAGGACCACTGAGGTTCCTTTC ACAGACAGAATCTGTCACAGCCTTCATGGGAGACACAGTGCTACTCAAGTG TGAAGTCATTGGGGAGCCCATGCCAACAATCCACTGGCAGAAGAACCAAC AAGACCTGACTCCAATCCCAGGTGACTCCCGAGTGGTGGTCTTGCCCTCTG GAGCATTGCAGATCAGCCGACTCCAACCGGGGGACATTGGAATTTACCGAT GCTCAGCTCGAAATCCAGCCAGCTCAAGAACAGGAAATGAAGCAGAAGTC AGAATTTTATCAGATCCAGGACTGCATAGACAGCTGTATTTTCTGCAAAGA CCATCCAATGTAGTAGCCATTGAAGGAAAAGATGCTGTCCTGGAATGTTGT GTTTCTGGCTATCCTCCACCAAGTTTTACCTGGTTACGAGGCGAGGAAGTCA TCCAACTCAGGTCTAAAAAGTATTCTTTATTGGGTGGAAGCAACTTGCTTAT CTCCAATGTGACAGATGATGACAGTGGAATGTATACCTGTGTTGTCACATA TAAAAATGAGAATATTAGTGCCTCTGCAGAGCTCACAGTCTTGGTTCCGCC ATGGTTTTTAAATCATCCTTCCAACCTGTATGCCTATGAAAGCATGGATATT GAGTTTGAATGTACAGTCTCTGGAAAGCCTGTGCCCACTGTGAATTGGATG AAGAATGGAGATGTGGTCATTCCTAGTGATTATTTTCAGATAGTGGGAGGA AGCAACTTACGGATACTTGGGGTGGTGAAGTCAGATGAAGGCTTTTATCAA TGTGTGGCTGAAAATGAGGCTGGAAATGCCCAGACCAGTGCACAGCTCATT GTCCCTAAGCCTGCTATCCCAAGCTCCAGTGTCCTCCCTTCGGCTCCCAGAG ATGTGGTCCCTGTCTTGGTTTCCAGCCGATTTGTCCGTCTCAGCTGGCGCCC ACCTGCAGAAGCGAAAGGGAACATTCAAACTTTCACGGTCTTTTTCTCCAG AGAAGGTGACAACAGGGAACGAGCATTGAATACAACACAGCCTGGGTCCC TTCAGCTCACTGTGGGAAACCTGAAGCCAGAAGCCATGTACACCTTTCGAG TTGTGGCTTACAATGAATGGGGACCGGGAGAGAGTTCTCAACCCATCAAGG TGGCCACACAGCCTGAGTTGCAAGTTCCAGGGCCAGTAGAAAACCTGCAAG CTGTATCTACCTCACCTACCTCAATTCTTATTACCTGGGAACCCCCTGCCTA TGCAAACGGTCCAGTCCAAGGTTACAGATTGTTCTGCACTGAGGTGTCCAC AGGAAAAGAACAGAATATAGAGGTTGATGGACTATCTTATAAACTGGAAG GCCTGAAAAAATTCACCGAATATAGTCTTCGATTCTTAGCTTATAATCGCTA TGGTCCGGGCGTCTCTACTGATGATATAACAGTGGTTACACTTTCTGACGTG CCAAGTGCCCCGCCTCAGAACGTCTCCCTGGAAGTGGTCAATTCAAGAAGT ATCAAAGTTAGCTGGCTGCCTCCTCCATCAGGAACACAAAATGGATTTATT ACCGGCTATAAAATTCGACACAGAAAGACGACCCGCAGGGGTGAGATGGA AACACTGGAGCCAAACAACCTCTGGTACCTATTCACAGGACTGGAGAAAGG AAGTCAGTACAGTTTCCAGGTGTCAGCCATGACAGTCAATGGTACTGGACC ACCTTCCAACTGGTATACTGCAGAGACTCCAGAGAATGATCTAGATGAATC TCAAGTTCCTGATCAACCAAGCTCTCTTCATGTGAGGCCCCAGACTAACTGC ATCATCATGAGTTGGACTCCTCCCTTGAACCCAAACATCGTGGTGCGAGGTT ATATTATCGGTTATGGCGTTGGGAGCCCTTACGCTGAGACAGTGCGTGTGG ACAGCAAGCAGCGATATTATTCCATTGAGAGGTTAGAGTCAAGTTCCCATT ATGTAATCTCCCTAAAAGCTTTTAACAATGCCGGAGAAGGAGTTCCTCTTTA TGAAAGTGCCACCACCAGGTCTATAACCGATCCCACTGACCCAGTTGATTA TTATCCTTTGCTTGATGATTTCCCCACCTCGGTCCCAGATCTCTCCACCCCCA TGCTCCCACCAGTAGGTGTACAGGCTGTGGCTCTTACCCATGATGCTGTGAG GGTCAGCTGGGCAGACAACTCTGTCCCTAAGAACCAAAAGACGTCTGAGGT GCGACTTTACACCGTCCGGTGGAGAACCAGCTTTTCTGCAAGTGCAAAATA CAAGTCAGAAGACACAACATCTCTAAGTTACACAGCAACAGGCCTCAAACC AAACACAATGTATGAATTCTCGGTCATGGTAACAAAAAACAGAAGGTCCAG TACTTGGAGCATGACTGCACATGCCACCACGTATGAAGCAGCCCCCACCTC TGCTCCCAAGGACTTGACAGTCATTACTAGGGAAGGGAAGCCTCGTGCCGT CATTGTGAGTTGGCAGCCTCCCTTGGAAGCCAATGGGAAAATTACTGCTTA CATCTTATTTTATACCTTGGACAAGAACATCCCAATTGATGACTGGATTATG GAAACAATCAGTGGTGATAGGCTTACTCATCAAATCATGGATCTCAACCTT GATACTATGTATTACTTTCGAATTCAAGCACGAAATTCAAAAGGAGTGGGG CCACTCTCTGATCCTATCCTCTTCAGGACTCTGAAAGTGGAACACCCTGACA AAATGGCTAATGACCAAGGTCGTCATGGAGATGGAGGTTATTGGCCAGTTG ATACTAATTTGATTGATAGAAGCACCCTAAATGAGCCGCCAATTGGACAAA TGCACCCCCCGCATGGCAGTGTCACTCCTCAGAAGAACAGCAACCTGCTTG TGATCATTGTGGTCACCGTTGGTGTCATCACAGTGCTGGTAGTGGTCATCGT GGCTGTGATTTGCACCCGACGCTCTTCAGCCCAGCAGAGAAAGAAACGGGC CACCCACAGTGCTGGCAAAAGGAAGGGCAGCCAGAAGGACCTCCGACCCC CTGATCTTTGGATCCATCATGAAGAAATGGAGATGAAAAATATTGAAAAGC CATCTGGCACTGACCCTGCAGGAAGGGACTCTCCCATCCAAAGTTGCCAAG ACCTCACACCAGTCAGCCACAGCCAGTCAGAAACCCAACTGGGAAGCAAA AGCACCTCTCATTCAGGTCAAGACACTGAGGAAGCAGGGAGCTCTATGTCC ACTCTGGAGAGGTCGCTGGCTGCACGCCGAGCCCCCCGGGCCAAGCTCATG ATTCCCATGGATGCCCAGTCCAACAATCCTGCTGTCGTGAGCGCCATCCCG GTGCCAACGCTAGAAAGTGCCCAGTACCCAGGAATCCTCCCGTCTCCCACC TGTGGATATCCCCACCCGCAGTTCACTCTCCGGCCTGTGCCATTCCCAACAC TCTCAGTGGACCGAGGTTTCGGAGCAGGAAGAAGTCAGTCAGTGAGTGAA GGACCAACTACCCAACAACCACCTATGCTGCCCCCATCTCAGCCTGAGCAT TCTAGCAGCGAGGAGGCACCAAGCAGAACCATCCCCACAGCTTGTGTTCGA CCAACTCACCCACTCCGCAGCTTTGCTAATCCTTTGCTACCTCCACCAATGA GTGCAATAGAACCGAAAGTCCCTTACACACCACTTTTGTCTCAGCCAGGGC CCACTCTTCCTAAGACCCATGTGAAAACAGCCTCCCTTGGGTTGGCTGGAA AAGCAAGATCCCCTTTGCTTCCTGTGTCTGTGCCAACAGCCCCTGAAGTGTC TGAGGAGAGCCACAAACCAACAGAGGATTCAGCCAATGTGTATGAACAGG ATGATCTGAGTGAACAAATGGCAAGTTTGGAAGGACTCATGAAGCAGCTTA ATGCCATCACAGGCTCAGCCTTTTAA KIF16B-> ATGGCATCGGTCAAGGTGGCCGTGAGGGTCCGGCCCATGAATCGCAGCTTC SEQ ID PCSK2 CCTTTGCTGAAGGTCTGTACCACTTTTATCACAATGGCCTTGCAAAGGCCAA NO:36 GAGAAGACGCAGCCTACACCACAAGCAGCAGCTGGAGAGAGACCCCAGGG TAAAGATGGCTTTGCAGCAGGAAGGATTTGACCGAAAAAAGCGAGGTTAC AGAGACATCAATGAGATCGACATCAACATGAACGATCCTCTTTTTACAAAG CAGTGGTATCTGATCAATACTGGGCAAGCTGATGGCACTCCTGGCCTTGATT TGAATGTGGCTGAAGCCTGGGAGCTGGGATACACAGGGAAAGGTGTTACC ATTGGAATTATGGATGATGGGATTGACTATCTCCACCCGGACCTGGCCTCC AACTATAATGCCGAAGCAAGTTACGACTTCAGCAGCAACGACCCCTATCCT TACCCTCGGTACACAGATGACTGGTTTAACAGCCACGGGACCCGATGTGCA GGAGAAGTTTCTGCTGCCGCCAACAACAATATCTGTGGAGTTGGAGTAGCA TACAACTCCAAGGTTGCAGGCATCCGGATGCTGGACCAGCCATTCATGACA GACATCATCGAGGCCTCCTCCATCAGTCATATGCCACAGCTGATTGACATCT ACAGCGCCAGCTGGGGCCCCACAGACAACGGCAAGACAGTGGATGGGCCC CGGGAGCTCACGCTGCAGGCCATGGCCGATGGCGTGAACAAGGGCCGCGG CGGCAAAGGCAGCATCTACGTGTGGGCCTCCGGGGACGGCGGCAGCTATG ACGACTGCAACTGCGACGGCTACGCCTCCAGCATGTGGACCATCTCCATCA ACTCAGCCATCAACGACGGCAGGACTGCCCTGTACGACGAGAGCTGCTCTT CCACCTTGGCTTCCACCTTCAGCAACGGGAGGAAAAGGAACCCCGAGGCCG GTGTGGCAACCACAGATTTGTACGGCAACTGCACTCTGAGGCATTCTGGGA CATCTGCAGCTGCCCCCGAGGCAGCTGGTGTGTTTGCACTGGCTCTGGAGG CTAACCTGGGTCTGACCTGGCGGGACATGCAGCATCTGACTGTGCTCACCT CCAAACGGAACCAGCTTCACGACGAGGTCCATCAGTGGCGGCGCAATGGG GTCGGCCTGGAATTTAATCACCTCTTTGGCTACGGGGTCCTTGATGCAGGTG CCATGGTGAAAATGGCTAAAGACTGGAAAACCGTGCCTGAGAGATTCCACT GTGTGGGAGGCTCCGTGCAGGACCCTGAGAAAATACCATCCACTGGCAAGT TGGTGCTGACACTCACAACCGACGCCTGTGAGGGGAAGGAAAATTTTGTCC GCTACCTGGAGCATGTCCAGGCTGTCATCACGGTCAACGCAACCAGAAGAG GAGACCTGAACATCAACATGACTTCCCCTATGGGCACCAAGTCCATTTTGCT GAGCCGGCGTCCAAGGGATGACGACTCCAAGGTGGGCTTTGACAAGTGGCC TTTCATGACCACTCACACGTGGGGGGAAGACGCCCGAGGCACCTGGACCCT GGAGCTGGGATTTGTCGGCAGCGCCCCGCAGAAGGGGGTGCTGAAGGAGT GGACCCTGATGCTGCATGGCACTCAGAGTGCCCCGTACATCGACCAGGTGG TGCGGGATTACCAGTCCAAGTTGGCCATGTCCAAGAAAGAGGAGCTGGAG GAAGAGCTGGACGAAGCCGTGGAGAGAAGCCTGAAAAGCATCCTTAACAA GAACTAG ACSL3-> GTCCCAGGCGGTTCCGCTCAACAGACGCTGCTGTGGCTGCGCCGGGCTGCG SEQ ID MOGAT1 ACACTGCAGTTGTCTACGCGGCCGGGGCCGGGACGAGGAGGCGTTGGACG NO:37 GGGTCGCATACGTTCGTCCCCTCGCATTGCGGCCCCGACAGCTGCGCCAGG ATCCCCGGGCGGCGGCGCGGGGCGTGAACGCTCTGGGGCTCAGCCAGGCCT GCGCGGGCCCGAGGCCGGAGGAACCCGGACTCCGGCGTAGCGGGCCGATG TCCATTGGAATCACTGTGATGCTGATCATACACAACTATTTGTTCCTTTACA TCCCTTATTTGATGTGGCTTTACTTTGACTGGCATACCCCAGAGCGAGGAGG CAGGAGATCCAGCTGGATCAAAAATTGGACTCTTTGGAAACACTTTAAGGA CTATTTTCCAATTCATCTTATCAAAACTCAAGATTTGGATCCAAGTCACAAC TATATATTTGGGTTTCACCCCCATGGAATAATGGCAGTTGGAGCCTTTGGGA ATTTTTCTGTAAATTATTCTGACTTCAAGGACCTGTTTCCTGGCTTTACTTCA TATCTTCACGTGCTGCCACTTTGGTTCTGGTGTCCTGTCTTTCGAGAATATGT GATGAGTGTTGGGCTGGTTTCAGTTTCCAAGAAAAGTGTGTCCTACATGGT AAGCAAGGAGGGAGGTGGAAACATCTCTGTCATTGTCCTTGGGGGTGCAAA AGAATCACTGGATGCTCATCCTGGAAAGTTCACTCTGTTCATCCGCCAGCG GAAAGGATTTGTTAAAATTGCTTTGACCCATGGCGCCTCTCTGGTCCCAGTG GTTTCTTTTGGTGAAAATGAACTGTTTAAACAAACTGACAACCCTGAAGGA TCATGGATTAGAACTGTTCAGAATAAACTGCAGAAGATCATGGGGTTTGCT TTGCCCCTGTTTCATGCCAGGGGAGTTTTTCAGTACAATTTTGGCCTAATGA CCTATAGGAAAGCCATCCACACTGTTGTTGGCCGCCCGATCCCTGTTCGTCA GACTCTGAACCCGACCCAGGAGCAGATTGAGGAGTTACATCAGACCTATAT GGAGGAACTTAGGAAATTGTTTGAGGAACACAAAGGAAAGTATGGCATTC CAGAGCACGAGACTCTTGTTTTAAAATGACTTGACTATAAAAAAAAATTAA AAAATAAAAATAAATGACT DLG5-> ATGGAGCCCCAGCGCCGGGAGCTGCTCGCCCAGTGTCAGCAGAGCCTGGCC SEQ ID ADK CAGGCCATGACGGAGGTGGAAGCCGTGCTCGGGCTGCTCGAGGCCGCGGG NO:38 AGCGCTCAGTCCCGGCGAGCGGCGGCAGCTGGACGAGGAGGCGGGAGGCG CCAAGGCGGAGCTGCTGCTCAAGCTGCTCTTGGCCAAGGAGCGGGACCACT TCCAGGACCTGCGGGCGGCGCTGGAGAAGACGCAGCCTCACCTGCTGCCCA TTCTCTACCTGAACGGCGTCGTCGGGCCGCCGCAGCCCGCCGAAGGCGCGG GTTCTACCTACAGCGTCCTGTCCACCATGCCCTCAGACTCAGAAAGCAGCA GCTCCCTCAGCAGTGTGGGCACTACCGGGAAGGCGCCGTCCCCACCACCCC TCCTCACTGACCAGCAAGTGAATGAGAAGGTGGAGAACCTCTCCATTCAGC TGCGGCTGATGACCCGGGAGAGAAACGAGCTCCGCAAGCGCCTGGCCTTTG CTACGCATGGCACGGCCTTTGACAAGAGGCCCTACCACAGGCTGAATCCTG ACTATGAGAGGCTGAAGATCCAGTGCGTGCGAGCCATGTCGGACCTGCAGA GCCTGCAGAACCAGCACACCAACGCCTTGAAGAGGTGTGAGGAGGTGGCC AAGGAGACTGACTTCTACCACACACTCCACAGCCGGCTCCTGAGTGACCAG ACTCGGCTGAAGGATGACGTGGACATGCTGAGGCGGGAGAATGGGCAGCT GCTGCGGGAGCGAAACCTGCTGCAGCAGTCATGGGAGGACATGAAGCGGC TCCACGAGGAGGACCAGAAGGAGATCGGTGACCTCCGTGCCCAGCAGCAG CAGTGGATGATTCAACAGCCACACAAAGCAGCAACATTTTTTGGATGCATT GGGATAGATAAATTTGGGGAGATCCTGAAGAGAAAAGCTGCTGAAGCCCA TGTGGATGCTCATTACTACGAGCAGAATGAGCAGCCAACAGGAACTTGTGC TGCATGCATCACTGGTGACAACAGGTCCCTCATAGCTAATCTTGCTGCTGCC AATTGTTATAAAAAGGAAAAACATCTTGATCTGGAGAAAAACTGGATGTTG GTAGAAAAAGCAAGAGTTTGTTATATAGCAGGCTTTTTTCTTACAGTTTCCC CAGAGTCAGTATTAAAGGTGGCTCACCATGCTTCTGAAAACAACAGGATTT TCACTTTGAATCTATCTGCACCGTTTATTAGCCAGTTCTACAAGGAATCATT GATGAAAGTTATGCCTTATGTTGATATACTTTTTGGAAATGAGACAGAAGC TGCCACTTTTGCTAGAGAGCAAGGCTTTGAGACTAAAGACATTAAAGAGAT AGCCAAAAAGACACAAGCCCTGCCAAAGATGAACTCAAAGAGGCAGCGAA TCGTGATCTTCACCCAAGGGAGAGATGACACTATAATGGCTACAGAAAGTG AAGTCACTGCTTTTGCTGTCTTGGATCAAGACCAGAAAGAAATTATTGATA CCAATGGAGCTGGAGATGCATTTGTTGGAGGTTTTCTGTCTCAACTGGTCTC TGACAAGCCTCTGACTGAATGTATCCGTGCTGGCCACTATGCAGCAAGCAT CATAATTAGACGGACTGGCTGCACCTTTCCTGAGAAGCCAGACTTCCACTG A VDAC3-> ATGTGTAACACACCAACGTACTGTGACCTAGGAAAGGCTGCTAAGGATGTC SEQ ID IL1RAPL TTCAACAAAGGATATGGCTTTGGCATGGTCAAGATAGACCTGAAAACCAAG NO:39 1 TCTTGTAGTGGAGTGGAATTTTCTACTTCTGGTCATGCTTACACTGATACAG GGAAAGCATCAGGCAACCTAGAAACCAAATATAAGGTCTGTAACTATGGA CTTACCTTCACCCAGAAATGGAACACAGACAATACTCTAGGGACAGAAATC TCTTGGGAGAATAAGCCGATGGATGCACTGACTGGTCTATCGATATCAAGA AATATCAAGTTTTGGTGGGAGAGCCTGTTCGAATCAAATGTGCACTCTTTTA TGGTTATATCAGAACAAATTACTCCCTTGCCCAAAGTGCTGGACTCAGTTTG ATGTGGTACAAAAGTTCTGGTCCTGGAGACTTTGAAGAGCCAATAGCCTTT GACGGAAGTAGAATGAGCAAAGAAGAAGACTCCATTTGGTTCCGGCCAAC ATTGCTACAGGACAGTGGTCTCTACGCCTGTGTCATCAGAAACTCCACTTAC TGTATGAAAGTATCCATCTCACTGACAGTGGGTGAAAATGACACTGGACTC TGCTATAATTCCAAGATGAAGTATTTTGAAAAAGCTGAACTTAGCAAAAGC AAGGAAATTTCATGCCGTGACATAGAGGATTTTCTACTGCCAACCAGAGAA CCTGAAATCCTTTGGTACAAGGAATGCAGGACAAAAACATGGAGGCCAAG TATTGTATTCAAAAGAGATACTCTGCTTATAAGAGAAGTCAGAGAAGATGA CATTGGAAATTATACCTGTGAATTAAAATATGGAGGCTTTGTTGTGAGAAG AACTACTGAATTAACTGTTACAGCCCCTCTGACTGATAAGCCACCCAAGCTT TTGTATCCTATGGAAAGTAAACTGACAATTCAGGAGACCCAGCTGGGTGAC TCTGCTAATCTAACCTGCAGAGCTTTCTTTGGGTACAGCGGAGATGTCAGTC CTTTAATTTACTGGATGAAAGGAGAAAAATTTATTGAAGATCTGGATGAAA ATCGAGTTTGGGAAAGTGACATTAGAATTCTTAAGGAGCATCTTGGGGAAC AGGAAGTTTCCATCTCATTAATTGTGGACTCTGTGGAAGAAGGTGACTTGG GAAATTACTCCTGTTATGTTGAAAATGGAAATGGACGTCGACACGCCAGCG TTCTCCTTCATAAACGAGAGCTAATGTACACAGTGGAACTTGCTGGAGGCC TTGGTGCTATACTCTTGCTGCTTGTATGTTTGGTGACCATCTACAAGTGTTA CAAGATAGAAATCATGCTCTTCTACAGGAATCATTTTGGAGCTGAAGAGCT CGATGGAGACAATAAAGATTATGATGCATACTTATCATACACCAAAGTGGA TCCTGACCAGTGGAATCAAGAGACTGGGGAAGAAGAACGTTTTGCCCTTGA AATCCTACCTGATATGCTTGAAAAGCATTATGGATATAAGTTGTTTATACCA GATAGAGATTTAATCCCAACTGGAACATACATTGAAGATGTGGCAAGATGT GTAGATCAAAGCAAGCGGCTGATTATTGTCATGACCCCAAATTACGTAGTT AGAAGGGGCTGGAGCATCTTTGAGCTGGAAACCAGACTTCGAAATATGCTT GTGACTGGAGAAATTAAAGTGATTCTAATTGAATGCAGTGAACTGAGAGGA ATTATGAACTACCAGGAGGTGGAGGCCCTGAAGCACACCATCAAGCTCCTG ACGGTCATTAAATGGCATGGACCAAAATGCAACAAGTTGAACTCCAAGTTC TGGAAACGTTTACAGTATGAAATGCCTTTTAAGAGGATAGAACCCATTACA CATGAGCAGGCTTTAGATGTCAGTGAGCAAGGGCCTTTTGGGGAGCTGCAG ACTGTCTCGGCCATTTCCATGGCCGCGGCCACCTCCACAGCTCTAGCCACTG CCCATCCAGATCTCCGTTCTACCTTTCACAACACGTACCATTCACAAATGCG TCAGAAACACTACTACCGAAGCTATGAGTACGACGTACCTCCTACCGGCAC CCTGCCTCTTACCTCCATAGGCAATCAGCATACCTACTGTAACATCCCTATG ACACTCATCAACGGGCAGCGGCCACAGACAAAATCGAGCAGGGAGCAGAA TCCAGATGAGGCCCACACAAACAGTGCCATCCTGCCGCTGTTGCCAAGGGA GACCAGTATATCCAGTGTGATATGGTGA ERBB2-> ATGGAGCTGGCGGCCTTGTGCCGCTGGGGGCTCCTCCTCGCCCTCTTGCCCC SEQ ID IKZF3 CCGGAGCCGCGAGCACCCAAGTGTGCACCGGCACAGACATGAAGCTGCGG NO:40 CTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAG GGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAAT GCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTC ATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGCGGATTGTG CGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAAT GGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGC CTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTC TTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAG GACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGACACCAAC CGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCT GGGGAGAGAGTTCTGAGGATTGTCAGAGCCATGATTCAATGAAAGTGAAA GATGAATACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGG AAATGCAGAAGAGCCTGAAATCCCTTACAGCTATTCAAGAGAATATAATGA ATATGAAAACATTAAGTTGGAGAGACATGTTGTCTCATTCGATAGTAGCAG GCCAACCAGTGGAAAGATGAACTGCGATGTGTGTGGATTATCCTGCATCAG CTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTC CAGTGTAATCAGTGTGGGGCATCTTTTACTCAGAAAGGTAACCTCCTCCGCC ACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACT ATGCATGCCAAAGAAGAGATGCGCTCACGGGGCATCTTAGGACACATTCTG TGGAGAAACCCTACAAATGTGAGTTTTGTGGAAGGAGTTACAAGCAGAGA AGTTCCCTTGAGGAGCACAAGGAGCGCTGCCGTACATTTCTTCAGAGCACT GACCCAGGGGACACTGCAAGTGCGGAGGCAAGACACATCAAAGCAGAGAT GGGAAGTGAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAA AACGAAAAAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGCGCCACTGCT TTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCA TACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTG GCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCTCGG AGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTG AGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTC CAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCC ACGACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCT ATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTC TGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCC AAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGT ATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGAT TCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGA TATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAA CACAGAGCCCTGCTGAAGTGA ERBB2-> ATGGAGCTGGCGGCCTTGTGCCGCTGGGGGCTCCTCCTCGCCCTCTTGCCCC SEQ ID IKZF3 CCGGAGCCGCGAGCACCCAAGTGTGCACCGGCACAGACATGAAGCTGCGG NO:41 CTCCCTGCCAGTCCCGAGACCCACCTGGACATGCTCCGCCACCTCTACCAG GGCTGCCAGGTGGTGCAGGGAAACCTGGAACTCACCTACCTGCCCACCAAT GCCAGCCTGTCCTTCCTGCAGGATATCCAGGAGGTGCAGGGCTACGTGCTC ATCGCTCACAACCAAGTGAGGCAGGTCCCACTGCAGAGGCTGCGGATTGTG CGAGGCACCCAGCTCTTTGAGGACAACTATGCCCTGGCCGTGCTAGACAAT GGAGACCCGCTGAACAATACCACCCCTGTCACAGGGGCCTCCCCAGGAGGC CTGCGGGAGCTGCAGCTTCGAAGCCTCACAGAGATCTTGAAAGGAGGGGTC TTGATCCAGCGGAACCCCCAGCTCTGCTACCAGGACACGATTTTGTGGAAG GACATCTTCCACAAGAACAACCAGCTGGCTCTCACACTGATAGACACCAAC CGCTCTCGGGCCTGCCACCCCTGTTCTCCGATGTGTAAGGGCTCCCGCTGCT GGGGAGAGAGTTCTGAGGATTGTCAGAGCCTGACGCGCACTGTCTGTGCCG GTGGCTGTGCCCGCTGCAAGGGGCCACTGCCCACTGACTGCTGCCATGAGC AGTGTGCTGCCGGCTGCACGGGCCCCAAGCACTCTGACTGCCTGGCCTGCC TCCACTTCAACCACAGTGGCATCTGTGAGCTGCACTGCCCAGCCCTGGTCAC CTACAACACAGACACGTTTGAGTCCATGCCCAATCCCGAGGGCCGGTATAC ATTCGGCGCCAGCTGTGTGACTGCCTGTCCCTACAACTACCTTTCTACGGAC GTGGGATCCTGCACCCTCGTCTGCCCCCTGCACAACCAAGAGGTGACAGCA GAGGATGGAACACAGCGGTGTGAGAAGTGCAGCAAGCCCTGTGCCCGAGA TGATTCAATGAAAGTGAAAGATGAATACAGTGAAAGAGATGAGAATGTTTT AAAGTCAGAACCCATGGGAAATGCAGAAGAGCCTGAAATCCCTTACAGCT ATTCAAGAGAATATAATGAATATGAAAACATTAAGTTGGAGAGACATGTTG TCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGATGTGT GTGGATTATCCTGCATCAGCTTCAATGTCTTAATGGTTCATAAGCGAAGCCA TACTGGTGAACGCCCATTCCAGTGTAATCAGTGTGGGGCATCTTTTACTCAG AAAGGTAACCTCCTCCGCCACATTAAACTGCACACAGGGGAAAAACCTTTT AAGTGTCACCTCTGCAACTATGCATGCCAAAGAAGAGATGCGCTCACGGGG CATCTTAGGACACATTCTGTGGAGAAACCCTACAAATGTGAGTTTTGTGGA AGGAGTTACAAGCAGAGAAGTTCCCTTGAGGAGCACAAGGAGCGCTGCCG TACATTTCTTCAGAGCACTGACCCAGGGGACACTGCAAGTGCGGAGGCAAG ACACATCAAAGCAGAGATGGGAAGTGAAAGAGCTCTCGTACTGGACAGAT TAGCAAGCAATGTGGCAAAACGAAAAAGCTCAATGCCTCAGAAATTCATTG GTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATG AGAAAGAGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAAT AACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACA CCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCA TAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAA AGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCT CTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCAACCATGAAG AACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCC GCAATGGGATGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCA AGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAG GGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGG ACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTT CGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTC TCACATAGCCAGAGGAGAACACAGAGCCCTGCTGAAGTGA EIF4A3-> ATGGCGACCACGGCCACGATGGCGACCTCGGGCTCGGCGCGAAAGCGGCT SEQ ID TSPEAR GCTCAAAGAGGAAGACATGACTAAAGTGGAATTCGAGACCAGCGAGGAGG NO:42 TGGATGTGACCCCCACGTTCGACACCATGGGCCTGCGGGAGGACCTGCTGC GGGGCATCTACGCTTACGAGGAACGAGTACCTGCTGACGGTGGTGGCAGAG GAGAGCGACCTGCTGCTGCTCGGCCTGCGGTTGTCACCTGCCCAGCTGCAC TTCCTGTTCCTTCGCGAGGACACGGCCGGCGCCTGGCAGACCCGAGTGTCC TTCCGCAGCCCGGCCCTGGTGGATGGCCGCTGGCACACACTGGTCCTGGCT GTGTCCGCAGGCGTCTTCTCCCTCACCACGGACTGCGGCCTCCCGGTGGAC ATAATGGCCGATGTGCCCTTCCCAGCCACCCTGTCAGTGAAAGGAGCTCGA TTCTTCGTCGGCAGCCGGAGGAGAGCCAAAGGCCTGTTCATGGGACTGGTG AGGCAACTGGTCCTGCTGCCGGGCTCAGACGCCACCCCAAGGCTGTGTCCC AGCAGGAACGCCCCGCTGGCGGTGCTGTCCATCCCACGGGTCCTGCAGGCT CTCACGGGGAAGCCAGAAGATAACGAGGTGCTAAAATATCCCTATGAAAC CAACATTCGAGTGACGCTGGGACCCCAGCCACCGTGTACCGAGGTGGAAGA CGCCCAGTTCTGGTTTGATGCCAGCCGGAAGGGCCTGTATCTGTGTGTTGGC AACGAGTGGGTCTCCGTGTTAGCAGCCAAAGAAAGACTGGACTACGTGGA GGAGCATCAGAACTTGTCCACCAACTCAGAGACCCTGGGCATTGAGGTGTT CCGCATCCCTCAGGTGGGGCTCTTTGTGGCCACAGCCAATCGCAAAGCCAC ATCCGCCGTCTACAAGTGGACCGAAGAGAAGTTCGTCTCATATCAGAACAT CCCCACGCACCAAGCACAGGCCTGGAGGCATTTCACCATCGGGAAAAAGAT CTTCCTGGCAGTGGCTAATTTTGAACCAGATGAGAAGGGTCAGGAGTTCTC TGTCATTTACAAATGGAGCCACAGAAAGCTGAAGTTTACCCCATATCAGAG CATTGCCACACACAGCGCCCGAGACTGGGAGGCCTTCGAGGTGGATGGGG AGCACTTCCTGGCGGTGGCCAACCACCGGGAAGGCGACAACCACAACATC GACAGTGTCATCTACAAGTGGAACCCGGCAACCCGGCTCTTCGAGGCCAAC CAGACCATCGCCACCTCCGGCGCCTACGACTGGGAGTTCTTCAGTGTGGGG CCCTACTCGTTCCTGGTGGTGGCCAACACCTTCAACGGCACCTCCACCAAG GTGCACTCGCACCTCTACATCCGACTCCTGGGCTCCTTCCAGCTCTTCCAGT CCTTCCCGACGTTCGGTGCTGCAGACTGGGAGGTCTTCCAGATCGGGGAGA GGATCTTCCTCGCTGTGGCAAACAGTCACAGCTACGATGTGGAGATGCAAG TCCAGAATGATTCCTATGTCATCAACTCCGTCATCTACGAGCTGAACGTGAC CGCGCAGGCCTTTGTCAAGTTCCAGGACATTCTCACCTGCAGTGCTCTGGAC TGGGAGTTTTTCTCGGTGGGAGAAGATTATTTCCTGGTGGTGGCCAACTCCT TCGATGGGCGTACCTTCTCGGTGAACAGTATTATTTACAGGTGGCAGGGCT ACGAGGGCTTCGTGGCGGTGCACAGCCTCCCCACCGTCGGCTGCAGGGACT GGGAGGCCTTCAGCACCACGGCTGGTGCCTACCTCATCTACTCCAGCGCCA AGGAGCCCCTCTCCAGGGTCCTGCGGCTGAGGACACGCTGA BCL7A-> ATGTCGGGCAGGTCGGTTCGAGCCGAGACGAGGAGCCGGGCCAAAGATGA SEQ ID C12orf42 TATCAAGAGGGTCATGGCGGCGATCGAGAAAGTGCGCAAATGGGAGAAGA NO:43 AATGGGTGACCGTTGGTGACACATCCCTACGAATCTACAAATGGGTCCCTG TGACGGAGCCCAAGGTTGATGACAAAAACAAGAATAAGAAAAAAGGCAAG GACGAGAAGTGTGGCTCAGAGGTGACCACTCCGGAGAACAGTTCCTCCCCA GGGATGATGGACATGCATGATGTCTACAGTGATATGTATGAAACAAAGGGA AGAAGAATTCTTGCTAACCATCAGACCTTTTGCAAACAGGATGCAGAAATC CCCTTGCTATATTCCCATTGTGAGCAGTGCCACCCTGTGGGATAGAAGCAC ACCCAGTGCAAAGCACATCCCTTGTTATGAAAGAACTTCAGTACCCTGCTC CAGATTCATTAATCACATGAAGAATTTCTCTGAATCTCCTAAATTTCGTAGT CTACACTTTCTGAATTTTCCAGTATTTCCAGAAAGGACTCAAAATTCAATGG CGTGTAAAAGACTACTTCATACTTGCCAGTACATAGTCCCCAGGTGTTCTGT AAGCACAGTTTCTTTTGATGAAGAAAGCTATGAAGAATTCCGTTCCTCTCCA GCACCATCCAGTGAAACTGATGAGGCCCCATTGATTTTTACTGCCAGAGGA GAAACTGAGGAGAGAGCCAGAGGAGCACCCAAGCAGGCTTGGAACAGTTC ATTTTTGGAACAACTGGTTAAAAAGCCTAACTGGGCACACTCAGTAAATCC TGTTCACCTGGAGGCTCAGGGCATACACATCAGTAGACACACAAGACCTAA GGGCCAGCCCTTGAGCAGTCCCAAGAAAAATTCTGGTTCTGCCGCCAGACC TTCCACTGCCATCGGCCTCTGCAGGAGGAGCCAGACGCCCGGCGCTCTGCA GAGCACCGGCCCGAGTAACACAGAGCTCGAGCCGGAGGAGAGGATGGCAG TCCCAGCAGGCGCTCAGGCACACCCCGACGACATCCAAAGCAGACTCCTGG GCGCGTCCGGAAATCCCGTCGGAAAAGGCGCGGTTGCCATGGCGCCGGAG ATGCTCCCCAAGCATCCTCATACCCCGCGGGACAGGAGGCCTCAGGCGGAC ACCTCCCTCCATGGCAATCTGGCAGGAGCGCCCCTTCCTCTGCTGGCCGGTG CTTCCACCCATTTCCCCTCCAAGAGGTTAATAAAGGTTTGCTCCTCAGCACC CCCCCGCCCAACCCGGCGTTTCCATACGGTTTGTTCACAGGCCCTTTCTAGG CCGGTGGTGAATGCTCACTTACATTGA ADK-> ATGACGTCAGTCAGAGAAAATATTCTCTTTGGAATGGGAAATCCTCTGCTT SEQ ID ClOorfl l GACATCTCTGCTGTAGTGGACAAAGATTTCCTTGATAAGTATTCTCTGAAAC NO:44 CAAATGACCAAATCTTGGCTGAAGACAAACACAAGGAACTGTCACTGGAA GGACTGAGCGCATTCAGGAGCCTGGAGGAACTCATCTTGGACAACAATCAG CTGGGGGACGACCTTGTGTTGCCAGGGTTACCCAGACTGCATACCTTAACC CTCAACAAGAACCGAATCACTGATTTGGAGAACCTGCTGGATCACTTGGCA GAAGTGACACCAGCTCTGGAGTACCTCAGTCTGCTGGGCAACGTGGCCTGT CCCAACGAGCTGGTCAGCTTGGAAAAGGATGAGGAAGACTACAAGAGATA CAGATGCTTTGTTCTGTACAAGCTGCCCAACTTGAAATTTCTGGATGCCCAG AAAGTAACCAGACAAGAACGAGAGGAGGCGTTGGTCAGAGGAGTCTTCAT GAAGGTGGTGAAGCCCAAGGCTTCTAGTGAGGACGTTGCCAGCTCCCCGGA GCGCCACTACACGCCCTTGCCTTCTGCTTCCAGGGAACTCACCAGTCACCA AGGTGTCCTGGGGAAGTGTCGCTACGTTTACTATGGGAAAAACTCAGAGGG CAACAGGTTTATCCGAGATGACCAGCTCTGA FAM135 GGTGAGAGAGGCCGGGGGCGGGGCCGTGCGGCCGGGGACCTGTTGATCGC SEQ ID A-> AGGTATAGCCGGCTGGCCCGGGCTCCCTCGGGACTGGGGCGACTGCGCATG NO:45 PKIB CTCGCTGGCCGCGCTGGGCCAGTAGCCGAGCCGCGGTGACGAACCGGCTCC GCGGTTGCGGTGTTTGCGGTTGCTGTGATGGCGATGTGAGGGGGCCCGGGG CGGGATGGTGCTGACCCGGGTCGGGCCGTCTTCTTGCAGCTGGACAACGAG CTCCTCCGTTCGACAGGCGGGGGAAGAGGCCGAGCCGGGCGAGAGATGTT GCTATGAGGACAGATTCATCAAAAATGACTGACGTGGAGTCTGGGGTCGCC AATTTTGCATCTTCAGCAAGGGCAGGCCGCCGGAATGCCTTACCAGACATC CAGAGTTCAGCTGCCACAGACGGAACCTCAGATTTGCCCCTCAAACTGGAG GCTCTCTCCGTGAAGGAAGATGCAAAAGAGAAAGATGAAAAAACAACACA AGACCAATTGGAAAAGCCTCAAAATGAAGAAAAATGAAGGCTCATAATCT ATCAAGAGTGCTGAATTTCTGCATGTTGAAAGACTTAGTGGTTCTGTTTTCT TGAGACATTTAATCTGGTGGTAACTGTGGTAACATTGCAGCCCTAAGCAGC ATGTGTATATTAGATAATTGTGTTGTGATGCTACTCACTTTGATTGCAATGA TGATGTCCAAGGTAAGCTATTAAAAGGCAGGTTACTTCCAAATCGCACTGA AGGAAAAGGTTAAGAATAATACATGATCACAGAAATGCATACCACTGTCTG TAAACCCAACAAAATTCACTGTTCTCTTTTGGATTTATTTAGCCTGATGTAT TTTTAATTCAATTTTTATGGTGATGGGCAAATCATTCTTGGTAAATGTAAAT CAAACATGATTGATTTAAAACTTCATGGAATTTGTAGAAAATTATGGACAT TTTTGGTGAGAAAGAACAATAGTCAAAACTCACATGGATAGAGTGTGTTTG TTTTTTGCCAAAAATGCCCCAGACTTTTTCCCAAACCTCAAAAACGTCTTGG AAAAATTGTAAAAGTTTGATAACAGAAACATCTTTAGGATATTTTTGTCTGA CATATTTTGCTTCTAGTATGTGCCTACTGTGATTTTTTTCATGTGGAAAATGC AAAATTTGTAACAAAATGGTTATATGGAACATGCCTATTAAATGAATTTTA CTATCTTCCCTAACTTTGGTCTGTGTATGTGTGTGTGTTTTACTTTAATATGA ATTATACAAAATACTAGTTGTTTTACACTCTCTTTTCTTATTCTTAGGGCTTT TGTGTATGTCTGACTTGTTTTTAAATAACTTCCTCAGCAATGCAGACCTTAA TTTTTATATTTTTTTAAAGTAGCTAACATAGCAGTAGGCACTTAAGCATTTA GTCAATGATATTGGTAGAAATAGTAAAATACATCCTTTAAATATATATCTA AGCATATATTTTAAAAGGAGCAAAAATAAAACCAAAGTGTTAGTAAATTTT GATTTATTAGATATTTTAGAAAAATAATAGAATTCTGAAGTTTTAAAAATGT CAGTAATTAATTTATTTTCATTTTCAGAAATATATGCATGCAGTTATGTTTTA TTTGATTGTTGACTTAGGCTATGTCTGTATACAGTAACCAAATAAACTCTTT CACTATTAAAGAGATTTCTTACTGAC CDC42BP ATGTCGGCCAAGGTGCGGCTCAAGAAGCTGGAGCAGCTGCTCCTGGACGGG SEQ ID B-> CCCTGGCGCAACGAGAGCGCCCTGAGCGTGGAAACGCTGCTCGACGTGCTC NO:46 PET1 12 GTCTGCCTGTACACCGAGTGCAGCCACTCGGCCCTGCGCCGCGACAAGTAC GTGGCCGAGTTCCTCGAGTGGGGTGTTTGAGGAACTGTGGAAGAGGGAAG GCAAGACTCCAGGGCAGATTGTTTCAGAAAAGCAGCTTGAACTGATGCAGG ACCAGGGGGCACTGGAGCAGCTCTGCCACTCTGTGATGGAGGCCCATCCTC AAGTGGTAATGGATGTGAAGAACAGAAACCCCAGAGCTATAAATAAACTG ATTGGGTTGGTCCGGAAAGCGACTCAAAGCCGAGCAGATCCAGTCATGATA AAGGAGATCCTGGAGAAGAAGCTGTCATTGTGA SAVl-> ATGCTGTCCCGAAAGAAAACCAAAAACGAAGTGTCCAAGCCGGCCGAGGT SEQ ID NIN GCAGGGGAAGTACGTGAAGAAGGAGACGTCGCCTCTGCTTCGGAATCTTAT NO:47 GCCTTCATTCATCCGGCATGGTCCAACAATTCCAAGACGAACTGATATCTGT CTTCCAGATTCAAGCCCTAATGCCTTTTCAACTTCTGGAGATGTAGTTTCAA GAAACCAGAGTTTCCTTAGAACTCCAATTCAAAGAACACCTCATGAAATAA TGAGAAGAGAAAGCAACAGATTATCTGCACCTTCTTATCTTGCCAGAAGTC TAGCAGATGTCCCTAGAGAGTATGGTTCTTCTCAGTCATTTGTAACGGAAGT TAGTTTTGCTGTTGAAAATGGAGACTCTGGTTCCCGATATTATTATTCAGAC AATTTTTTTGATGGTCAGAGAAAGCGGCCACTTGGAGATCGTGCACATGAA GACTACAGATATTATGAATACAACCATGATCTCTTCCAAAGAATGCCACAG AATCAGGGGAGGCATGCTTCAGCACTGGAAGACGCAACGCAGTGAGGAGT ATGAAGCGGAAGGCCAGTTAAGGTTTTGGAACCCAGATGACTTGAATGCTT CACAGAGTGGATCTTCCCCTCCCCAAGACTGGATAGAAGAGAAACTGCAAG AAGTTTGTGAAGATTTGGGGATCACCCGTGATGGTCACCTGAACCGGAAGA AGCTGGTCTCCATCTGTGAGCAGTATGGTTTACAGAATGTGGATGGAGAGA TGCTCGAGGAAGTATTCCATAATCTTGATCCTGACGGTACAATGAGTGTAG AAGATTTTTTCTATGGTTTGTTTAAAAATGGAAAATCTCTTACACCATCAGC ATCTACTCCATATAGACAACTAAAAAGGCACCTTTCCATGCAGTCTTTCGAT GAGAGTGGACGACGTACCACAACCTCATCAGCAATGACAAGTACCATTGGC TTTCGGGTCTTCTCCTGCCTGGATGATGGGATGGGCCATGCATCTGTGGAGA GAATACTGGACACCTGGCAGGAAGAGGGCATTGAGAACAGCCAGGAGATC CTGAAGGCCTTGGATTTCAGCCTCGATGGAAACATCAATTTGACAGAATTA ACACTGGCCCTTGAAAATGAACTTTTGGTTACCAAGAACAGCATTCACCAG GCGGCTCTGGCCAGCTTTAAGGCTGAAATCCGGCATTTGTTGGAACGAGTT GATCAGGTGGTCAGAGAAAAAGAGAAGCTACGGTCAGATCTGGACAAGGC CGAGAAGCTCAAGTCTTTAATGGCCTCGGAGGTGGATGATCACCATGCGGC CATAGAGCGGCGGAATGAGTACAACCTCAGGAAACTGGATGAAGAGTACA AGGAGCGAATAGCAGCCTTAAAAAATGAACTCCGAAAAGAGAGAGAGCAG ATCCTGCAGCAGGCAGGCAAGCAGCGTTTAGAACTTGAACAGGAAATTGA AAAGGCAAAAACAGAAGAGAACTATATCCGGGACCGCCTTGCCCTCTCTTT AAAGGAAAACAGTCGTCTGGAAAATGAGCTTCTAGAAAATGCAGAGAAGT TGGCAGAATATGAGAATCTGACAAACAAACTTCAGAGAAATTTGGAAAAT GTGTTAGCAGAAAAGTTTGGTGACCTCGATCCTAGCAGTGCTGAGTTCTTCC TGCAAGAAGAGAGACTGACACAGATGAGAAATGAATATGAGCGGCAGTGC AGGGTACTACAAGACCAAGTAGATGAACTCCAGTCTGAGCTGGAAGAATAT CGTGCACAAGGCAGAGTGCTCAGGCTTCCGTTGAAGAACTCACCGTCAGAA GAAGTTGAGGCTAACAGCGGTGGCATTGAGCCCGAACACGGGCTCGGTTCT GAAGAATGCAATCCATTGAATATGAGCATTGAGGCAGAGCTGGTCATTGAA CAGATGAAAGAACAACATCACAGGGACATATGTTGCCTCAGACTGGAGCTC GAAGATAAAGTGCGCCATTATGAAAAGCAGCTGGACGAAACCGTGGTCAG CTGCAAGAAGGCACAGGAGAACATGAAGCAAAGGCATGAGAACGAAACGC ACACCTTAGAAAAACAAATAAGTGACCTTAAAAATGAAATTGCTGAACTTC AGGGGCAAGCAGCAGTGCTCAAGGAGGCACATCATGAGGCCACTTGCAGG CATGAGGAGGAGAAAAAACAACTGCAAGTGAAGCTTGAGGAGGAAAAGAC TCACCTGCAGGAGAAGCTGAGGCTGCAACATGAGATGGAGCTCAAGGCTA GACTGACACAGGCTCAAGCAAGCTTTGAGCGGGAGAGGGAAGGCCTTCAG AGTAGCGCCTGGACAGAAGAGAAGGTGAGAGGCTTGACTCAGGAACTAGA GCAGTTTCACCAGGAGCAGCTGACAAGCCTGGTGGAGAAACACACTCTTGA GAAAGAGGAGTTAAGAAAAGAGCTCTTGGAAAAGCACCAAAGGGAGCTTC AGGAGGGAAGATATGAATCTGAAAAGCTTCAACAGGAAAATTCTATTTTGA GAAATGAAATTACTACTTTAAATGAAGAAGATAGCATTTCTAACCTGAAAT TAGGGACATTAAATGGATCTCAGGAAGAAATGTGGCAAAAAACGGAAACT GTAAAACAAGAAAATGCTGCAGTTCAGAAGATGGTTGAAAATTTAAAGAA ACAGATTTCAGAATTAAAAATCAAAAACCAACAATTGGATTTGGAAAATAC AGAACTTAGCCAAAAGAACTCTCAAAACCAGGAAAAACTGCAAGAACTTA ATCAACGTCTAACAGAAATGCTATGCCAGAAGGAAAAAGAGCCAGGAAAC AGTGCATTGGAGGAACGGGAACAAGAGAAGTTTAATCTGAAAGAAGAACT GGAACGTTGTAAAGTGCAGTCCTCCACTTTAGTGTCTTCTCTGGAGGCGGA GCTCTCTGAAGTTAAAATACAGACCCATATTGTGCAACAGGAAAACCACCT TCTCAAAGATGAACTGGAGAAAATGAAACAGCTGCACAGATGTCCCGATCT CTCTGACTTCCAGCAAAAAATCTCTAGTGTTCTAAGCTACAACGAAAAACT GCTGAAAGAAAAGGAAGCTCTGAGTGAGGAATTAAATAGCTGTGTCGATA AGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATTGCGACGATGAAGCAGG AACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAGCTGGTG GCTTCTCAGGAAAAGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAAC CTGCAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAG GAGGCTTTAAAACAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCT GGTGGCAAGAGCTGGGCCCCAGAGATAGCTACTCATCCATCAGGGCTCCAT AACCAGCAGAAAAGGCTGTCCTGGGACAAGTTGGATCATCTGATGAATGAG GAACAGCAGCTGCTTTGGCAAGAGAATGAGAGGCTCCAGACCATGGTACA GAACACCAAAGCCGAACTCACGCACTCCCGGGAGAAGGTCCGTCAGTTGG AATCCAATCTTCTTCCCAAGCACCAAAAACATCTAAACCCATCAGGTACCA TGAATCCCACAGAGCAAGAAAAATTGAGCTTAAAGAGAGAGTGTGATCAG TTTCAGAAAGAACAATCTCCTGCTAACAGGAAGGTCAGTCAGATGAATTCC CTTGAACAAGAATTAGAAACAATTCATTTGGAAAATGAAGGCCTGAAAAA GAAACAAGTAAAACTGGATGAGCAGCTCATGGAGATGCAGCACCTGAGGT CCACTGCGACGCCTAGCCCGTCCCCTCATGCTTGGGATTTGCAGCTGCTCCA GCAGCAAGCCTGTCCGATGGTGCCCAGGGAGCAGTTTCTGCAGCTTCAACG CCAGCTGCTGCAGGCAGAAAGGATAAACCAGCACCTGCAGGAGGAACTTG AAAACAGGACCTCCGAAACCAACACACCACAGGGAAACCAGGAACAACTG GTAACTGTCATGGAGGAACGAATGATAGAAGTTGAACAGAAACTGAAACT AGTGAAAAGGCTTCTTCAAGAGAAAGTGAATCAGCTCAAAGAACAAGTGA GCCTACCCGGTCATCTCTGTTCACCCACCTCACATTCCAGCTTTAACTCCAG TTTTACATCCCTTTATTGCCATTAA RE G-> ATGGCTAAAAGTGCGGAGGTCAAACTGGCAATATTTGGGAGAGCAGGCGT SEQ ID GZMM GGGCAAGTCAGGCAGCTCCTTTGGGACCCAGATCATCGGGGGCCGGGAGGT NO:48 GATCCCCCACTCGCGCCCGTACATGGCCTCACTGCAGAGAAATGGCTCCCA CCTGTGCGGGGGTGTCCTGGTGCACCCAAAGTGGGTGCTGACGGCTGCCCA CTGCCTGGCCCAGCGGATGGCCCAGCTGAGGCTGGTGCTGGGGCTCCACAC CCTGGACAGCCCCGGTCTCACCTTCCACATCAAGGCAGCCATCCAGCACCC TCGCTACAAGCCCGTCCCTGCCCTGGAGAACGACCTCGCGCTGCTTCAGCT GGACGGGAAAGTGAAGCCCAGCCGGACCATCCGGCCGTTGGCCCTGCCCA GTAAGCGCCAGGTGGTGGCAGCAGGGACTCGGTGCAGCATGGCCGGCTGG GGGCTGACCCACCAGGGCGGGCGCCTGTCCCGGGTGCTGCGGGAGCTGGAC CTCCAAGTGCTGGACACCCGCATGTGTAACAACAGCCGCTTCTGGAACGGC AGCCTCTCCCCCAGCATGGTCTGCCTGGCGGCCGACTCCAAGGACCAGGCT CCCTGCAAGGGTGACTCGGGCGGGCCCCTGGTGTGTGGCAAAGGCCGGGTG TTGGCCAGAGTCCTGTCCTTCAGCTCCAGGGTCTGCACTGACATCTTCAAGC CTCCCGTGGCCACCGCTGTGGCGCCTTACGTGTCCTGGATCAGGAAGGTCA CCGGCCGATCGGCCTGA DMKN-> ATGAAGTTCCAGGGGCCCCTGGCCTGCCTCCTGCTGGCCCTCTGCCTGGGCA SEQ ID LGI4 GTGGGGAGGCTGGCCCCCTGCAGAGCGGAGAGGAAAGCACTGGGACAAAT NO:49 ATTGGGGAGGCCCTTGGACATGGCCTGGGAGACGCCCTGAGCGAAGGGGT GGGAAAGGCCATTGGCAAAGAGGCCGGAGGGGCAGCTGGCTCTAAAGTCA GTGAGGCCCTTGGCCAAGGGACCAGAGAAGCAGTTGGCACTGGAGTCAGG CAGGTTCCAGGCTTTGGCGTAGCAGATGCTTTGGGCAACAGGGTCGGGGAA GCAGCCCATGCTCTGGGAAACACTGGGCACGAGATTGGCAGACAGGCAGA AGATGTCATTCGACACGGAGCAGATGCTGTCCGCGGCTCCTGGCAGGGGGT GCCTGGCCACAATGGTGCTTGGGAAACTTCTGGAGGCCATGGCATCTTTGG CTCTCAAGGTGGCCTTGGAGGCCAGGGCCAGGGCAATCCTGGAGGTCTGGG GACTCCGTGGGTCCACGGATACCCCGGAAACTCAGCAGGCAGCTTTGGAAT GAATCCTCAGGGAGCTCCCTGGGGTCAAGGAGGCAATGGAGGGCCACCAA ACTTTGGGACCAACACTCAGGGAGCTGTGGCCCAGCCTGGCTATGGTTCAG TGAGAGCCAGCAACCAGAATGAAGGGTGCACGAATCCCCCACCATCTGGCT CAGGTGGAGGCTCCAGCAACTCTGGGGGAGGCAGCGGCTCACAGTCGGGC AGCAGTGGCAGTGGCAGCAATGGTGACAACAACAATGGCAGCAGCAGTGG TGGCAGCAGCAGTGGCAGCAGCAGTGGCGGCAGCAGTGGCGGCAGCAGTG GTGGCAGCAGTGGCAACAGTGGTGGCAGCAGAGGTGACAGCGGCAGTGAG TCCTCCTGGGGATCCAGCACCGGCTCCTCCTCCGGCAACCACGGTGGGAGC GGCGGAGGAAATGGACATAAACCCGGGTGTGAAAAGCCAGGGAATGAAGC CCGCGGGAGCGGGGAATCTGGGATTCAGAACTCTGAGACGTCTCCTGGGAT GTTTAACTTTGACACTTTCTGGAAGAATTTTAAATCCAAGCTGGGTTTCATC AACTGGGATGCCATAAACAAGAACCAGGTCCCGCCCCCCAGCACCCGAGC CCTCCTCTACTTCAGCCGACTCTGGGAGGATTTCAAACAGAACACTCCTTTC CTCAACTGGAAAGCAATTATTGAGGGTGCGGACGCGTCATCACTGCAGAAA CGTGCAGGCAGAGACGATCAGAACTACAATTACAACCAGCATGCGTATCCC ACTGCCTATGGTGGGAAGTACTCAGTCAAGACCCCTGCAAAGGGGGGAGTC TCACCTTCTTCCTCGGCTTCCCGGGTGCAACCTGGCCTGCTGCAGTGGGTGA AGTTTTGGTAGAGCTGTCCTGGTTCCAGACGGTGGGGGAGTCGGCACTGAG CGTAGAGCCCTTCTCCTACCAAGGGGAGCCTCACATTGTGCTGGCACAGCC CTTCGCCGGCCGCTGCCTGATTCTCTCCTGGGACTACAGCCTGCAGCGCTTC CGGCCCGAGGAAGAGCTGCCCGCGGCCTCCGTGGTGTCCTGCAAGCCACTG GTGCTGGGCCCGAGCCTCTTCGTGCTGGCTGCCCGCCTGTGGGGGGGCTCA CAGCTGTGGGCCCGGCCCAGTCCCGGCCTGCGCCTGGCCCCAACGCAGACC CTGGCCCCGCGGCGGCTGCTGCGGCCCAATGACGCCGAGCTCCTGTGGCTG GAAGGGCAACCCTGCTTCGTGGTGGCCGATGCCTCCAAGGCGGGCAGCACC ACGCTGCTGTGCCGCGACGGGCCCGGCTTTTACCCGCACCAGAGCCTGCAC GCCTGGCACCGGGACACGGACGCTGAGGCCCTGGAGCTGGACGGCCGGCC CCACCTGCTGCTGGCCTCGGCTTCCCAGCGGCCCGTGCTCTTCCACTGGACC GGTGGCCGCTTCGAGAGACGCACAGACATCCCCGAGGCCGAGGATGTCTAT GCCACACGCCACTTCCAGGCTGGTGGGGACGTGTTCCTGTGCCTCACACGC TACATTGGGGACTCCATGGTCATGCGCTGGGACGGCTCCATGTTTCGTCTGC TGCAGCAACTTCCCTCGCGCGGTGCCCACGTCTTCCAGCCACTGCTCATCGC CAGGGACCAGCTGGCCATCCTAGGCAGCGACTTCGCCTTCAGCCAGGTCCT CCGCCTTGAGCCTGACAAGGGGCTCCTGGAGCCACTGCAGGAGCTGGGGCC TCCGGCCCTGGTGGCCCCCCGTGCCTTTGCCCACATCACTATGGCCGGCAG ACGCTTCCTCTTTGCTGCTTGCTTTAAGGGCCCCACACAGATCTACCAGCAT CACGAGATCGACCTCAGTGCCTGA UTP18-> ATGCCGCCGGAGCGGAGGAGACGAATGAAACTGGACCGGAGAACCGGAGC SEQ ID ACACA GAAGCCGAAGCGGAAGCCCGGAATGAGGCCGGACTGGAAAGCCGGAGCGG NO:50 GGCCAGGCGGGCCTCCCCAAAAGCCTGCCCCTTCATCCCAGCGGAAACCGC CGGCCCGGCCGAGCGCGGCGGCCGCTGCGATTGCAGTCGCGGCGGCGGAG GAAGAGAGACGGCTCCGGCAGCGGAACCGCCTGAGGCTGGAGGAGGACAA ACCGGCCGTGGAGCGGTGCTTGGAGGAGCTGGTCTTCGGCGACGTCGAGAA CGACGAGGACGCGTTGCTGCGGCGTCTGCGAGGCCCGAGGGTTCAAGAAC ATGAAGACTCGGGTGACTCAGAAGTGGAGAATGAAGCAAAAGGTAATTTT CCACCTCAAAAGAAGCCAGTTTGGGTGGATGAAGAAGATGAAGATGAGGA AATGGTTGACATGATGAACAATCGGTTTCGGAAGGATATGATGAAAAATGC TAGTGAAAGTAAACTTTCGAAAGACAACCTTAAAAAGAGACTTAAAGAAG AATTCCAACATGCCATGGGAGGAGTACCTGCCTGGGCAGAGACTACTAAGC GGAAAACATCTTCAGATGATGAAAGTGAAGAGGATGAAGATGATTTGTTGC AAAGGACTGGGAATTTCATATCCACATCAACTTCTCTTCCAAGAGGAATCTT GAAGATGAAGAACTGCCAGCATGCGAATGCTGAACGTCCTACTGTTGCTCG GATCTCATCTGTGCAGTTCCATCCCGGTGCACAGATTGTGATGGTTGCTGGA TTAGATAATGCTGTATCACTATTTCAGGTTGATGGGAAAACAAATCCTAAA ATTCAGAGCATCTATTTGGAAAGGTTTCCAATCTTTAAGGCTTGTTTTAGTG CTAATGGGGAAGAAGTTTTAGCCACGAGTACCCACAGCAAGGTTCTTTATG TCTATGACATGCTGGCTGGAAAGTTAATTCCTGTGCATCAAGTGAGAGGTC CTCGGGCGGGAAGTGTACACCTCCAATAACCAGCTGGGGGGCATCCAGATT ATGCACAACAATGGGGTGACCCACTGCACTGTGTGTGATGACTTTGAAGGG GTTTTCACTGTCCTGCACTGGCTGTCTTACATGCCCAAGAGCGTGCACAGTT CAGTTCCTCTTCTGAACTCAAAGGATCCTATAGACAGAATCATCGAGTTTGT TCCCACAAAGACCCCATACGATCCTCGATGGATGCTAGCAGGCCGTCCTCA CCCAACCCAAAAAGGTCAGTGGTTGAGTGGCTTTTTTGACTATGGATCTTTC TCAGAGATTATGCAGCCCTGGGCACAGACTGTGGTGGTTGGTAGAGCCAGG CTAGGAGGAATACCTGTGGGAGTTGTTGCTGTAGAAACCCGAACAGTAGAA CTAAGTATCCCAGCTGATCCAGCAAACCTGGATTCTGAAGCCAAGATAATC CAGCAGGCTGGCCAGGTTTGGTTCCCAGATTCTGCGTTTAAGACATATCAG GCCATCAAGGACTTCAACCGGGAAGGGCTGCCTCTGATGGTCTTTGCCAAC TGGAGAGGCTTCTCTGGTGGAATGAAAGATATGTACGACCAAGTGCTGAAG TTTGGTGCTTACATTGTGGATGGCTTGAGGGAGTGCTGCCAGCCTGTGCTGG TTTACATTCCTCCCCAGGCTGAGCTGCGGGGTGGCTCCTGGGTGGTGATTGA CTCCTCCATCAACCCCCGGCACATGGAGATGTATGCTGACCGAGAAAGCAG GGGATCTGTTCTGGAGCCAGAAGGGACAGTAGAAATCAAATTCCGCAGAA AGGATCTGGTGAAAACCATGCGTCGGGTGGACCCAGTCTACATCCACTTGG CTGAGCGATTGGGGACCCCAGAGCTAAGCACAGCTGAGCGGAAGGAGTTG GAGAACAAGTTGAAGGAGCGGGAGGAATTCCTAATTCCCATTTACCATCAG GTAGCCGTGCAGTTTGCTGACTTGCACGACACACCAGGCCGGATGCAGGAG AAGGGTGTTATTAGCGATATCCTGGATTGGAAAACATCCCGTACCTTCTTCT ACTGGCGGCTGAGGCGTCTTCTGCTGGAGGACCTGGTCAAGAAGAAAATCC ACAATGCCAACCCTGAGCTGACTGATGGCCAGATTCAAGCCATGTTAAGGC GCTGGTTTGTGGAAGTGGAAGGAACAGTGAAGGCTTATGTTTGGGACAATA ATAAGGATCTGGCGGAGTGGCTAGAGAAACAGCTGACAGAGGAGGATGGT GTTCACTCGGTAATAGAGGAAAACATCAAATGCATCAGCAGAGACTACGTC CTCAAGCAAATCCGCAGCTTGGTCCAGGCCAATCCAGAGGTTGCCATGGAT TCCATCATCCATATGACGCAGCACATATCACCCACTCAGCGAGCAGAAGTC ATACGGATCCTCTCCACAATGGATTCCCCTTCCACGTAG APP-> ATGCTGCCCGGTTTGGCACTGCTCCTGCTGGCCGCCTGGACGGCTCGGGCG SEQ ID C21orf7 CTGGAGGTACCCACTGATGGTAATGCTGGCCTGCTGGCTGAACCCCAGATT NO:51 GCCATGTTCTGTGGCAGACTGAACATGCACATGAATGTCCAGAATGGGAAG TGGGATTCAGATCCATCAGGGACCAAAACCTGCATTGATACCAAGGAAGGC ATCCTGCAGTATTGCCAAGAAGTCTACCCTGAACTGCAGATCACCAATGTG GTAGAAGCCAACCAACCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCG CAAGCAGTGCAAGACCCATCCCCACTTTGTGATTCCCTACCGCTGCTTAGTT GGTGAGTTTGTAAGTGATGCCCTTCTCGTTCCTGACAAGTGCAAATTCTTAC ACCAGGAGAGGATGGATGTTTGCGAAACTCATCTTCACTGGCACACCGTCG CCAAAGAGACATGCAGTGAGAAGAGTACCAACTTGCATGACTACGGCATGT TGCTGCCCTGCGGAATTGACAAGTTCCGAGGGGTAGAGTTTGTGTGTTGCC CACTGGCTGAAGAAAGTGACAATGTGGATTCTGCTGATGCGGAGGAGGATG ACTCGGATGTCTGGTGGGGCGGAGCAGACACAGACTATGCAGATGGGAGT GAAGACAAAGTAGTAGAAGTAGCAGAGGAGGAAGAAGTGGCTGAGGTGG AAGAAGAAGAAGCCGATGATGACGAGGACGATGAGGATGGTGATGAGGTA GAGGAAGAGGCTGAGGAACCCTACGAAGAAGCCACAGAGAGAACCACCAG CATTGCCACCACCACCACCACCACCACAGAGTCTGTGGAAGAGGTGGTTCG AGAGGTGTGCTCTGAACAAGCCGAGACGGGGCCGTGCCGAGCAATGATCTC CCGCTGGTACTTTGATGTGACTGAAGGGAAGTGTGCCCCATTCTTTTACGGC GGATGTGGCGGCAACCGGAACAACTTTGACACAGAAGAGTACTGCATGGC CGTGTGTGGCAGCGCCATGTCCCAAAGTTTACTCAAGACTACCCAGGAACC TCTTGCCCGAGATCCTGTTAAACTTCCTACAACAGCAGCCAGTACCCCTGAT GCCGTTGACAAGTATCTCGAGACACCTGGGGATGAGAATGAACATGCCCAT TTCCAGAAAGCCAAAGAGAGGCTTGAGGCCAAGCACCGAGAGAGAATGTC CCAGGTCATGAGAGAATGGGAAGAGGCAGAACGTCAAGCAAAGAACTTGC CTAAAGCTGATAAGAAGGCAGTTATCCAGCATTTCCAGGAGAAAGTGGAAT CTTTGGAACAGGAAGCAGCCAACGAGAGACAGCAGCTGGTGGAGACACAC ATGGCCAGAGTGGAAGCCATGCTCAATGACCGCCGCCGCCTGGCCCTGGAG AACTACATCACCGCTCTGCAGGCTGTTCCTCCTCGGCCTCGTCACGTGTTCA ATATGCTAAAGAAGTATGTCCGCGCAGAACAGAAGGACAGACAGCACACC CTAAAGCATTTCGAGCATGTGCGCATGGTGGATCCCAAGAAAGCCGCTCAG ATCCGGTCCCAGGTTATGACACACCTCCGTGTGATTTATGAGCGCATGAATC AGTCTCTCTCCCTGCTCTACAACGTGCCTGCAGTGGCCGAGGAGATTCAGG ATGAAGTTGGAAGGAGCTCATTGCCAAGTTAGATCAGGCAGAAAAGGAGA AGGTGGATGCTGCTGAGCTGGTTCGGGAATTCGAGGCTCTGACGGAGGAGA ATCGGACGTTGAGGTTGGCCCAGTCTCAATGTGTGGAACAACTGGAGAAAC TTCGAATACAGTATCAGAAGAGGCAGGGCTCGTCCTAA GREB 1-> GCATTACGCGCCCCACGCATCCTCTTCCATCCCCAGGCACAGATCAAAGGC SEQ ID MBOAT2 GCAGCCCAGGAGGCGGGAGCCCCTGCACACTTTCCACCTCTGCTGGGCTTA NO:52 GCCTCTTGGCTGGTTGGTCTGTGGAGTGCCTGAAGTGACCAGCTTTTTGTAA GGTCAACTTTGTAGTGTGCCAACTCTTTGCCTTGCTAGCAGCCATTTGGTTT CGAACTTATCTACATTCAAGCAAAACTAGCTCTTTTATAAGACATGTAGTTG CTACCCTTTTGGGCCTTTATCTTGCACTTTTTTGCTTTGGATGGTATGCCTTA CACTTTCTTGTACAAAGTGGAATTTCCTACTGTATCATGATCATCATAGGAG TGGAGAACATGCACAATTACTGCTTTGTGTTTGCTCTGGGATACCTCACAGT GTGCCAAGTTACTCGAGTCTATATCTTTGACTATGGACAATATTCTGCTGAT TTTTCAGGCCCAATGATGATCATTACTCAGAAGATCACTAGTTTGGCTTGCG AAATTCATGATGGGATGTTTCGGAAGGATGAAGAACTGACTTCCTCACAGA GGGATTTAGCTGTAAGGCGCATGCCAAGCTTACTGGAGTATTTGAGTTACA ACTGTAACTTCATGGGGATCCTGGCAGGCCCACTTTGCTCTTACAAAGACTA CATTACTTTCATTGAAGGCAGATCATACCATATCACACAATCTGGTGAAAA TGGAAAAGAAGAGACACAGTATGAAAGAACAGAGCCATCTCCAAATACTG CGGTTGTTCAGAAGCTCTTAGTTTGTGGGCTGTCCTTGTTATTTCACTTGACC ATCTGTACAACATTACCTGTGGAGTACAACATTGATGAGCATTTTCAAGCTA CAGCTTCGTGGCCAACAAAGATTATCTATCTGTATATCTCTCTTTTGGCTGC CAGACCCAAATACTATTTTGCATGGACGCTAGCTGATGCCATTAATAATGCT GCAGGCTTTGGTTTCAGAGGGTATGACGAAAATGGAGCAGCTCGCTGGGAC TTAATTTCCAATTTGAGAATTCAACAAATAGAGATGTCAACAAGTTTCAAG ATGTTTCTTGATAATTGGAATATTCAGACAGCTCTTTGGCTCAAAAGGGTGT GTTATGAACGAACCTCCTTCAGTCCAACTATCCAGACGTTCATTCTCTCTGC CATTTGGCACGGGGTATACCCAGGATATTATCTAACGTTTCTAACAGGGGT GTTAATGACATTAGCAGCAAGAGCTATGAGAAATAACTTTAGACATTATTT CATTGAACCTTCCCAACTGAAATTATTTTATGATGTTATAACATGGATAGTA ACTCAAGTAGCAATAAGTTACACAGTTGTGCCATTTGTGCTTCTTTCTATAA AACCATCACTCACGTTTTACAGCTCCTGGTATTATTGCCTGCACATTCTTGG TATCTTAGTATTATTGTTGTTGCCAGTGAAAAAAACTCAAAGAAGAAAGAA TACACATGAAAACATTCAGCTCTCACAATCCAAAAAGTTTGATGAAGGAGA AAATTCTTTGGGACAGAACAGTTTTTCTACAACAAACAATGTTTGCAATCA GAATCAAGAAATAGCCTCGAGACATTCATCACTAAAGCAGTGATCGGGAA GGCTCTGAGGGCTGTTTTTTTTTTTTGATGTTAACAGAAACCAATCTTAGCA CCTTTTCAAGGGGTTTGAGTTTGTTGGAAAAGCAGTTAACTGGGGGGAAAT GGACAGTTATAGATAAGGAATTTCCTGTACACCAGATTGGAAATGGAGTGA AACAAGCCCTCCCATGCCATGTCTCCGTGGGCCACGCCTTATGTAAGAATA TTTCCATATTTCAGTGGGCACTCCCAACCTCAGCACTTGTCCGTAGGGTCAC ACGCGTGCCCTGTTGCTGAATGTATGTTGCGTATCCCAAGGCACTGAAGAG GTGGAAAAATAATCGTGTCAATCTGGATGATAGAGAGAAATTAACTTTTCC AAATGAATGTCTTGCCTTAAACCCTCTATTTCCTAAAATATTGTTCCTAAAT GGTATTTTCAAGTGTAATATTGTGAGAACGCTACTGCAGTAGTTGATGTTGT GTGCTGTAAAGGATTTTAGGAGGAATTTGAAACAGGATATTTAAGAGTGTG GATATTTTTAAAATGCAATAAACATCTCAGTATTTGAAGGGTTTTCTTAAAG TATGTCAAATGACTACAATCCATAGTGAAACTGTAAACAGTAATGGACGCC AAATTATAGGTAGCTGATTTTGCTGGAGAGTTTAATTACCTTGTGCAGTCAA AGAGCGCTTCCAGAAGGAATCTCTTAAAACATAATGAGAGGTTTGGTAATG TGATATTTTAAGCTTATTCTTTTTCTTAAAAGAGAGAGGTGACGAAGGAAG GCAGGAATGAAGAAGCACTGCGTGGCCTCCGGTGGAATGCACGGGGCACA GCCGCGACTCTGCAGGCAGCTTCCCCCCCATGCCAGGGCTCTGCGCCGTCA TGTGAGACTTAAAAAAAAAGTTGAATGACTTCGTGATACTTTGGACTTCTA AATTAAATTTATCAGGCATAAATTATGTAGAATTAGAGGCTTTGAAAATAA TACTGGTAGGTTGCTCAAAGGTTTTGAAAGAGAAATCGCTAGGTAGGTTAC TATCTGGCTAATCCATTTCTTATCCTTGACAATTTAATTCATATTTGGGAAA CTTTTAGGGAAATGAAAAATAAAAGTCACTGAGTCTGGGTGACATTTTTTA AGAATAATATAAATTCAGTTTCAAACTCTTCTCACATTAAAATTTTGCTGTG AACTCTTACTAAAATGAGTTTTAGGTTCTGTAAGTGGAAAAATGTGCTTTTA TTTTATGGGCCATTTTTACCACAACTAATCTTGCCTTGGATTACTAAGCATC TCCTGCGATCCCACAGAGGACTGTGGTGGCCACAGGAGCTGAAAGCAGAA GAGTGGGATTTGATGCCAGGCAGTGGAGTGGCCTCAGCCCCAGATTGTACC TCCTGCCCTGTAGGAGGGGAGGGGGCAAAGCCTTCTGACTTCACCTTTGTTT GACCTATGTATGGAACTTACTTTTACTTTTTGCCTTAAATTTTTAATGAAATG CAAATTTTCTGTGATGGGGTTCTCTCTCTCTTTTTTTCGGGGGGTGGAGTCA CTAATAAATTTGCAAATGAAGTTAAAGACAAGGCAACCATCTGGCTTATGC TATATAATACTTCATTTAAAGAAGAAAGGAAAAGCAAATGCACTTGCAGCT TTTGAGGTCTCAGCAAAAATGGGCATGTGTCTTTTTTGAAGTTTAGAAATAT CCTAATCTATTTTTATTTATCTAAAAGTAAGTGTTTTCCGGCTGATAAGGCT AACCCTACCCAGGAAAGGATTGATAACTAAATAAATTTCCTCTGTTTTCCCA TGCATTGAAATTATGTTGGCTGAGCATGGTGGCTCACACCTGTAATCCTAGC ACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTGGAGACC AGCCTGGCCAACGTGGTGAATCCCCGTCTCTACTGAAAACACAAAAATTAG ACGGGCATGGTGGCGCACACCTGTAATCCCAGCTACTTGGGAGGCTGAGGC AGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTAAAATTGT GCCACTGCACTCCAGCCTGGGTGACAGAGGAAGACTCCGTCTCAC MED13L- ATGACTGCGGCAGCGAACTGGGTGGCGAACGGGGCGAGCCTGGAGGATTG SEQ ID > TCACTCCAACCTCTTTTCGCTGGCTGAACTCACGGGAATCAAATGGCGTAG NO:53 KIF21A GTACAATTTTGGAGGGCATGGGGACTGTGGACCCATAATTTCAGCCCCAGC CCAAGATGATCCAATTCTGTTAAGTTTCATCCGCTGTCTGCAAGCTAACCTG CTTTGTGTATGGCGTCGTGATGTCAAACCAGATTGCAAAGAGTTATGGATA TTCTGGTGGGGAGATGAACCCAACCTAGTGGGTGTAATACATCATGAACTG CAGGTTGTGGAAGAAGGACTCTGGGAAAATGGCCTTTCCTATGAATGTAGG ACGCTGCTCTTCAAAGCGATCCACAATCTGTTAGAAAGGTGCCTAATGGAT AAGAACTTCGTTAGGATTGGGAAATGGTTTGTCCGACCCTACGAAAAGGAT GAAAAGCCAGTCAACAAAAGTGAGCATTTGTCCTGTGCTTTCACATTCTTTC TGCATGGAGAAAGTAATGTATGCACAAGTGTGGAGATTGCCCAGCACCAGC CAATTTATTTGATCAATGAGGAGCATATACACATGGCTCAGTCTTCACCTGC ACCATTTCAAGTACTGGTAAGTCCTTATGGCTTAAATGGGACGCTAACAGG CCAAGCATACAAGATGTCAGACCCAGCCACTCGTAAGTTGATTGAGGAATG GCAGTATTTCTACCCGATGGTGCTAAAAAAGAAAGAAGAATCGAAAGAGG AAGACGAGTTGGGATATGATGATGATTTCCCTGTGGCAGTTGAAGTAATTG TTGGTGGTGTTCGGATGGTTTACCCTTCAGCATTTGTTTTGATCTCTCAGAAT GACATCCCGGTTCCTCAGAGTGTTGCCAGTGCTGGAGGCCACATTGCAGTT GGGCAGCAAGGGCTTGGTAGTGTGAAGGACCCAAGTAACTGTGGGATGCCT CTGACCCCTCCCACCTCTCCAGAACAGGCTATCCTAGGTGAGAGTGGAGGT ATGCAGAGTGCTGCCAGTCACCTGGTTTCCCAAGATGGAGGGATGATAACG ATGCACAGTCCAAAGAGATCGGGGAAGATTCCTCCAAAACTCCACAATCAT ATGGTCCATCGAGTCTGGAAGGAATGCATCCTCAACAGAACCCAGTCCAAG AGGAGCCAAATGTCAACTCCAACTCTTGAAGAAGAGCCTGCTAGCAATCCT GCTACTTGGGATTTTGTGGATCCAACCCAAAGAGTCAGCTGTTCTTGTTCCA GAATAAGACCACAGCTTGCCAAAGAGAAGATTGAAGGATGCCATATTTGTA CATCTGTCACACCAGGAGAGCCTCAGGTCTTCCTAGGGAAAGATAAGGCTT TTACTTTTGACTATGTATTTGACATTGACTCCCAGCAAGAGCAGATCTACAT TCAATGTATAGAAAAACTAATTGAAGGTTGCTTTGAAGGATACAATGCTAC AGTTTTTGCTTATGGACAAACTGGAGCTGGTAAAACATACACAATGGGAAC AGGATTTGATGTTAACATTGTTGAGGAAGAACTGGGTATTATTTCTCGAGCT GTTAAACACCTTTTTAAGAGTATTGAAGAAAAAAAACACATAGCAATTAAA AATGGGCTTCCTGCTCCAGATTTTAAAGTGAATGCCCAATTCTTAGAGCTCT ATAATGAAGAGGTCCTTGACTTATTTGATACCACTCGTGATATTGATGCAAA AAGTAAAAAATCAAATATAAGAATTCATGAAGATTCAACTGGAGGAATTTA TACTGTGGGCGTTACAACACGTACTGTGAATACAGAATCAGAGATGATGCA GTGTTTGAAGTTGGGTGCTTTATCCCGGACAACTGCCAGTACCCAGATGAA TGTTCAGAGCTCTCGTTCACATGCCATTTTTACCATTCATGTGTGTCAAACC AGAGTGTGTCCCCAAATAGATGCTGACAATGCAACTGATAATAAAATTATT TCTGAATCAGCACAGATGAATGAATTTGAAACCCTGACTGCAAAGTTCCAT TTTGTTGATCTCGCAGGATCTGAAAGACTGAAGCGTACTGGAGCTACAGGC GAGAGGGCAAAAGAAGGCATTTCTATCAACTGTGGACTTTTGGCACTTGGC AATGTAATAAGTGCCTTGGGAGACAAGAGCAAGAGGGCCACACATGTCCC CTATAGAGATTCCAAGCTAACAAGACTACTACAGGATTCCCTCGGGGGTAA TAGCCAAACAATCATGATAGCATGTGTCAGCCCTTCAGACAGAGACTTTAT GGAAACGTTAAACACCCTGAAATACGCCAATCGAGCTAGAAATATCAAGA ATAAGGTGATGGTCAATCAGGACAGAGCTAGTCAGCAAATCAATGCACTTC GTAGTGAAATCACACGACTTCAGATGGAGCTCATGGAGTACAAAACAGGTA AAAGAATAATTGACGAAGAGGGTGTGGAAAGCATCAATGACATGTTTCATG AGAATGCTATGCTACAGACTGAAAATAATAACCTGCGTGTAAGAATTAAAG CCATGCAAGAGACGGTTGATGCATTGAGGTCCAGAATTACACAGCTTGTTA GTGATCAGGCCAACCATGTTCTTGCCAGAGCAGGTGAAGGAAATGAGGAG ATTAGTAATATGATTCATAGTTATATAAAAGAAATCGAAGATCTCAGGGCA AAATTATTAGAAAGTGAAGCAGTGAATGAGAACCTTCGAAAAAACTTGAC AAGAGCCACAGCAAGAGCGCCATATTTCAGCGGATCATCAACTTTTTCTCC TACCATACTATCCTCAGACAAAGAAACCATTGAAATTATAGACCTAGCAAA AAAAGATTTAGAGAAGTTGAAAAGAAAAGAAAAGAGGAAGAAAAAAAGT GTGGCTGGTAAAGAGGATAATACAGACACTGACCAAGAGAAGAAAGAAGA AAAGGGTGTTTCGGAAAGAGAAAACAATGAATTAGAAGTGGAAGAAAGTC AAGAAGTGAGTGATCATGAGGATGAAGAAGAGGAGGAGGAGGAGGAGGA AGATGACATTGATGGGGGTGAAAGTTCTGATGAATCAGATTCTGAATCAGA TGAAAAAGCCAATTATCAAGCAGACTTGGCAAACATTACTTGTGAAATTGC AATTAAGCAAAAGCTGATTGATGAACTAGAAAACAGCCAGAAAAGACTGC AGACTCTGAAAAAGCAGTATGAAGAGAAGCTAATGATGCTGCAACATAAA ATTCGGGATACTCAGCTTGAAAGAGACCAGGTGCTTCAAAACTTAGGCTCG GTAGAATCTTACTCAGAAGAAAAAGCAAAAAAAGTTAGGTCTGAATATGA AAAGAAACTCCAAGCCATGAACAAAGAACTGCAGAGACTTCAAGCAGCTC AAAAAGAACATGCAAGGTTGCTTAAAAATCAGTCTCAGTATGAAAAGCAAT TGAAGAAATTGCAGCAGGATGTGATGGAAATGAAAAAAACAAAGGTTCGC CTAATGAAACAAATGAAAGAAGAACAAGAGAAAGCCAGACTGACTGAGTC TAGAAGAAACAGAGAGATTGCTCAGTTGAAAAAGGATCAACGTAAAAGAG ATCATCAACTTAGACTTCTGGAAGCCCAAAAAAGAAACCAAGAAGTGGTTC TACGTCGCAAAACTGAAGAGGTTACGGCTCTTCGTCGGCAAGTAAGACCCA TGTCAGATAAAGTGGCTGGGAAAGTTACTCGGAAGCTGAGTTCATCTGATG CACCTGCTCAGGACACAGGTTCCAGTGCAGCTGCTGTCGAAACAGATGCAT CAAGGACAGGAGCCCAGCAGAAAATGAGAATTCCTGTGGCGAGAGTCCAG GCCTTACCAACGCCGGCAACAAATGGAAACAGGAAAAAATATCAGAGGAA AGGATTGACTGGCCGAGTGTTTATTTCCAAGACAGCTCGCATGAAGTGGCA GCTCCTTGAGCGCAGGGTCACAGACATCATCATGCAGAAGATGACCATTTC CAACATGGAGGCAGATATGAATAGACTCCTCAAGCAACGGGAGGAACTCA CAAAAAGACGAGAGAAACTTTCAAAAAGAAGGGAGAAGATAGTCAAGGA GAATGGAGAGGGAGATAAAAATGTGGCTAATATCAATGAAGAGATGGAGT CACTGACTGCTAATATCGATTACATCAATGACAGTATTTCTGATTGTCAGGC CAACATAATGCAGATGGAAGAAGCAAAGGAAGAAGGTGAGACATTGGATG TTACTGCAGTCATTAATGCCTGCACCCTTACAGAAGCCCGATACCTGCTAGA TCACTTCCTGTCAATGGGCATCAATAAGGGTCTTCAGGCTGCCCAGAAAGA GGCTCAAATTAAAGTACTGGAAGGTCGACTCAAACAAACAGAAATAACCA GTGCTACCCAAAACCAGCTCTTATTCCATATGTTGAAAGAGAAGGCAGAAT TAAATCCTGAGCTAGATGCTTTACTAGGCCATGCTTTACAAGATCTAGATAG CGTACCATTAGAAAATGTAGAGGATAGTACTGATGAGGATGCTCCTTTAAA CAGCCCAGGATCAGAAGGAAGCACGCTGTCTTCAGATCTCATGAAGCTTTG TGGTGAAGTGAAACCTAAGAACAAGGCCCGAAGGAGAACCACCACTCAGA TGGAATTGCTGTATGCAGATAGCAGTGAACTAGCTTCAGACACTAGTACAG GAGATGCCTCCTTGCCTGGCCCTCTCACACCTGTTGCAGAAGGGCAAGAGA TTGGAATGAATACAGAGACAAGTGGTACTTCTGCTAGGGAAAAAGAGCTCT CTCCCCCACCTGGCTTACCTTCTAAGATAGGCAGCATTTCCAGGCAGTCATC TCTATCAGAAAAAAAAATTCCAGAGCCTTCTCCTGTAACAAGGAGAAAGGC ATATGAGAAAGCAGAAAAATCAAAGGCCAAGGAACAAAAGCACTCAGATT CTGGAACTTCAGAGGCTAGTCTTTCACCTCCTTCTTCCCCACCAAGCCGGCC CCGTAATGAACTGAATGTTTTTAATCGTCTTACTGTTTCTCAGGGAAACACA TCAGTTCAGCAGGATAAGTCTGATGAAAGTGACTCCTCTCTCTCGGAGGTA CACAGATCCTCCAGAAGGGGCATAATCAACCCATTTCCTGCTTCAAAAGGA ATCAGAGCTTTTCCACTTCAGTGTATTCACATAGCTGAAGGGCATACAAAA GCTGTGCTCTGTGTGGATTCTACTGATGATCTCCTCTTCACTGGATCAAAAG ATCGTACTTGTAAAGTATGGAATCTGGTGACTGGGCAGGAAATAATGTCAC TGGGGGGTCATCCCAACAATGTCGTGTCTGTAAAATACTGTAATTATACCA GTTTGGTCTTCACTGTATCAACATCTTATATTAAGGTGTGGGATATCAGAGA TTCAGCAAAGTGCATTCGAACACTAACGTCTTCAGGTCAAGTTACTCTTGGA GATGCTTGTTCTGCAAGTACCAGTCGAACAGTAGCTATTCCTTCTGGAGAG AACCAGATCAATCAAATTGCCCTAAACCCAACTGGCACCTTCCTCTATGCTG CTTCTGGAAATGCTGTCAGGATGTGGGATCTTAAAAGGTTTCAGTCTACAG GAAAGTTAACAGGACACCTAGGCCCTGTTATGTGCCTTACTGTGGATCAGA TTTCCAGTGGACAAGATCTAATCATCACTGGCTCCAAGGATCATTACATCA AAATGTTTGATGTTACAGAAGGAGCTCTTGGGACTGTGAGTCCCACCCACA ATTTTGAACCCCCTCATTATGATGGCATAGAAGCACTAACCATTCAAGGGG ATAACCTATTTAGTGGGTCTAGAGATAATGGAATCAAGAAATGGGACTTAA CTCAAAAAGACCTTCTTCAGCAAGTTCCAAATGCACATAAGGATTGGGTCT GTGCCCTGGGAGTGGTGCCAGACCACCCAGTTTTGCTCAGTGGCTGCAGAG GGGGCATTTTGAAAGTCTGGAACATGGATACTTTTATGCCAGTGGGAGAGA TGAAGGGTCATGATAGTCCTATCAATGCCATATGTGTTAATTCCACCCACAT TTTTACTGCAGCTGATGATCGAACTGTGAGAATTTGGAAGGCTCGCAATTTG CAAGATGGTCAGATCTCTGACACAGGAGATCTGGGGGAAGATATTGCCAGT AATTAA ITGAl l-> ATGGACCTGCCCAGGGGCCTGGTGGTGGCCTGGGCGCTCAGCCTGTGGCCA SEQ ID NARF GGGTTCACGGACACCTTCAACATGGACACCAGGAAGCCCCGGGTCATCCCT NO:54 GGCTCCAGGACCGCCTTCTTTGGCTACACAGTGCAGCAGCACGACATCAGT GGCAATAAGTGGAATGTAGTAAGAAAACAAAAACTGATGACCAAGAGAAT GTGTCAGCCGATGCACCGAGTCCAGCCCAGGAAAATGGAGAGAAGGGAGA ATTCCACAAGTTGGCTGATGCCAAGATATTTTTGAGCGACTGCCTGGCATGT GACAGCTGTATGACTGCAGAGGAAGGAGTCCAACTTTCCCAGCAAAATGCC AAGGACTTCTTCCGCGTTCTGAACCTTAACAAGAAATGTGATACCTCAAAG CACAAAGTGCTGGTAGTGTCTGTGTGTCCTCAATCTTTGCCTTATTTTGCTG CTAAATTCAACCTCAGTGTAACTGATGCATCCAGAAGACTCTGTGGTTTCCT CAAAAGTCTTGGGGTGCACTATGTATTTGATACGACGATAGCTGCGGATTTT AGTATCCTGGAGAGTCAAAAAGAATTCGTGCGTCGCTATCGCCAGCACAGT GAGGAGGAACGCACCCTGCCCATGCTGACCTCTGCCTGTCCTGGCTGGGTC CGATACGCCGAGCGGGTGCTGGGTCGCCCCATCACTGCCCACCTCTGCACC GCCAAGTCCCCCCAGCAGGTCATGGGCTCTTTGGTGAAGGATTATTTCGCC AGACAGCAGAACCTGTCTCCAGAGAAGATTTTCCACGTCATTGTGGCCCCT TGTTATGACAAGAAGCTGGAGGCTCTTCAGGAAAGCCTTCCCCCTGCTTTGC ATGGCTCCCGGGGCGCTGACTGCGTGTTAACATCAGGTGAAATTGCTCAAA TAATGGAGCAAGGTGACCTCTCAGTGAGAGATGCTGCCGTCGACACTCTGT TTGGAGACTTGAAGGAGGACAAAGTGACGCGTCATGATGGAGCCAGCTCA GACGGGCACCTGGCACACATCTTCAGACATGCGGCCAAGGAGCTGTTCAAC GAGGATGTGGAGGAGGTCACTTACCGAGCCCTGAGAAACAAAGACTTCCA AGAGGTCACCCTTGAGAAGAACGGAGAGGTGGTGTTACGCTTTGCTGCAGC CTATGGCTTTCGAAACATCCAGAACATGATCCTGAAGCTTAAGAAGGGCAA GTTCCCATTCCACTTTGTGGAGGTCCTCGCCTGTGCTGGAGGATGCTTAAAT GGCAGAGGCCAAGCCCAGACTCCAGACGGACATGCGGATAAGGCCCTGCT GCGGCAGATGGAAGGCATTTACGCTGACATCCCTGTGCGGCGTCCGGAGTC CAGTGCACACGTGCAGGAGCTGTACCAGGAGTGGCTGGAGGGGATCAACT CCCCCAAGGCCCGAGAGGTGCTGCATACCACGTACCAGAGCCAGGAGCGT GGCACACACAGCCTGGACATCAAGTGGTGA LDLRAD ATGTGGCTGCTGGGGCCGCTGTGCCTGCTGCTGAGCAGCGCCGCGGAGAGC SEQ ID 3-> CAGCTGCTCCCCGGGAACAACTTCACCAATGAGTGCAACATACCAGGCAAC NO:55 ANK3 TTCATGTGCAGCAATGGACGGTGCATCCCGGGCGCCTGGCAGTGTGACGGG CTGCCTGACTGCTTCGACAAGAGTGATGAGAAGGAGTGCCTCTGATGCCAA TGCAAGTTACTTAAGAGCAGCTCGAGCTGGACACCTTGAAAAGGCCCTCGA CTACATAAAAAATGGAGTTGACATCAACATTTGCAATCAGAATGGGTTGAA CGCTCTCCACCTTGCTTCCAAAGAAGGCCATGTAGAGGTTGTTTCTGAGCTG CTGCAGAGAGAAGCCAATGTGGATGCAGCTACAAAGAAAGGAAACACAGC ATTGCACATCGCATCTTTGGCTGGGCAAGCAGAGGTGGTAAAAGTCTTGGT TACAAATGGAGCCAATGTCAATGCACAATCTCAGAATGGTTTCACGCCATT GTATATGGCAGCCCAGGAAAATCACCTGGAAGTTGTCAAGTTTCTTCTTGA CAATGGTGCAAGCCAGAGCCTAGCCACAGAGGATGGCTTCACACCATTGGC AGTGGCTTTGCAACAAGGTCACGACCAAGTCGTTTCGCTCCTGCTAGAGAA TGACACCAAAGGAAAAGTGCGTCTCCCAGCTCTTCATATCGCGGCCCGAAA AGACGACACGAAAGCCGCCGCCCTGCTGCTGCAGAATGACAACAATGCAG ATGTGGAATCAAAGAGTGGCTTCACTCCGCTCCACATAGCTGCTCACTATG GAAATATCAATGTAGCCACGTTGCTGTTAAACCGAGCGGCTGCTGTGGATT TCACCGCAAGGAATGACATCACTCCTTTACATGTTGCATCAAAAAGAGGAA ATGCAAATATGGTAAAACTATTGCTCGATCGAGGAGCTAAAATCGATGCCA AAACCAGGGATGGTCTGACACCACTGCACTGTGGAGCAAGGAGTGGCCAC GAGCAGGTGGTAGAAATGTTGCTTGATCGAGCTGCCCCCATTCTTTCAAAA ACCAAGAATGGATTATCTCCATTGCACATGGCCACACAAGGGGATCATTTA AACTGCGTCCAGCTTCTCCTCCAGCATAATGTACCCGTGGATGATGTCACCA ATGACTACCTGACTGCCCTACACGTGGCTGCCCACTGTGGCCATTACAAAG TTGCCAAGGTTCTCTTGGATAAGAAAGCTAACCCCAATGCCAAAGCCCTGA ATGGCTTTACCCCTCTTCATATTGCCTGCAAGAAGAATCGAATTAAAGTAAT GGAACTCCTTCTGAAACACGGTGCATCCATCCAAGCTGTAACCGAGTCGGG CCTTACCCCAATCCATGTTGCTGCCTTCATGGGGCATGTAAATATTGTATCA CAACTAATGCATCATGGAGCCTCACCAAACACCACCAATGTGAGAGGAGA AACAGCACTGCACATGGCAGCTCGCTCCGGCCAAGCTGAAGTTGTGCGGTA TCTGGTACAAGACGGAGCTCAGGTAGAAGCTAAAGCTAAGGATGACCAAA CACCACTCCACATTTCAGCCCGACTGGGGAAAGCAGACATAGTACAACAGC TGTTGCAGCAAGGGGCATCTCCAAATGCAGCCACAACTTCTGGGTACACCC CACTTCACCTTTCCGCCCGAGAGGGGCATGAGGATGTGGCCGCGTTCCTTTT GGATCATGGAGCGTCTTTATCTATAACAACAAAGAAAGGATTTACTCCTCTT CATGTGGCAGCAAAATATGGAAAGCTTGAAGTCGCCAATCTCCTGCTACAG AAAAGTGCATCTCCAGATGCTGCTGGGAAGAGCGGGCTAACACCACTGCAT GTAGCTGCACATTACGATAATCAGAAAGTGGCCCTTCTGCTTTTGGACCAA GGAGCCTCACCTCACGCAGCCGCAAAGAATGGTTATACGCCACTGCACATC GCTGCCAAAAAGAACCAGATGGACATAGCGACAACTCTGCTGGAATATGGT GCTGATGCCAACGCAGTTACCCGGCAAGGAATTGCTTCCGTCCATCTCGCA GCTCAGGAAGGGCACGTGGACATGGTGTCGCTGCTCCTCGGTAGAAATGCG AATGTGAACCTGAGCAATAAGAGCGGCCTGACCCCACTCCATTTGGCTGCT CAAGAAGATCGAGTGAATGTGGCAGAAGTCCTCGTAAACCAAGGGGCTCA TGTGGACGCCCAGACAAAGATGGGATACACACCACTGCATGTGGGCTGCCA CTATGGAAATATCAAGATTGTTAATTTCCTGCTCCAGCATTCTGCAAAAGTT AATGCCAAAACAAAGAATGGGTATACGCCATTACATCAAGCAGCACAGCA GGGGCATACGCATATAATAAATGTCTTACTTCAGAACAACGCCTCCCCCAA TGAACTCACTGTGAATGGGAATACTGCCCTTGGCATTGCCCGGCGCCTCGG CTACATCTCAGTAGTGGACACCCTGAAGATAGTGACCGAAGAGACCATGAC CACAACTACTGTCACAGAGAAGCACAAAATGAATGTTCCAGAAACGATGA ATGAAGTTCTTGATATGTCTGATGATGAAGTTCGTAAAGCCAATGCCCCTG AAATGCTCAGTGATGGCGAATATATCTCAGATGTTGAAGAAGGTGAAGATG CAATGACCGGGGACACAGACAAATATCTTGGGCCACAGGACCTTAAGGAA TTGGGTGATGATTCCCTGCCTGCAGAGGGTTACATGGGCTTTAGTCTCGGAG CGCGTTCTGCCAGCCTCCGCTCCTTCAGTTCGGATAGGTCTTACACCTTGAA CAGAAGCTCCTATGCACGGGACAGCATGATGATTGAAGAACTCCTTGTGCC ATCCAAAGAGCAGCATCTAACATTCACAAGGGAATTTGATTCAGATTCTCT TAGACATTACAGCTGGGCTGCAGACACCTTAGACAATGTCAATCTTGTTTCA AGCCCCATTCATTCTGGGTTTCTGGTTAGCTTTATGGTGGACGCGAGAGGGG GCTCCATGAGAGGAAGCCGTCATCACGGGATGAGAATCATCATTCCTCCAC GCAAGTGTACGGCCCCCACTCGAATCACCTGCCGTTTGGTAAAGAGACATA AACTGGCCAACCCACCCCCCATGGTGGAAGGAGAGGGATTAGCCAGTAGG CTGGTAGAAATGGGTCCTGCAGGGGCACAATTTTTAGGCCCTGTCATAGTG GAAATCCCTCACTTTGGGTCCATGAGAGGAAAAGAGAGAGAACTCATTGTT CTTCGAAGTGAAAATGGTGAAACTTGGAAGGAGCATCAGTTTGACAGCAAA AATGAAGATTTAACCGAGTTACTTAATGGCATGGATGAAGAACTTGATAGC CCAGAAGAGTTAGGGAAAAAGCGTATCTGCAGGATTATCACGAAAGATTTC CCCCAGTATTTTGCAGTGGTTTCCCGGATTAAGCAGGAAAGCAACCAGATT GGTCCTGAAGGTGGAATTCTGAGCAGCACCACAGTGCCCCTTGTTCAAGCA TCTTTCCCAGAGGGTGCCCTAACTAAAAGAATTCGAGTGGGCCTCCAGGCC CAGCCTGTTCCAGATGAAATTGTGAAAAAGATCCTTGGAAACAAAGCAACT TTTAGCCCAATTGTCACTGTGGAACCAAGAAGACGGAAATTCCATAAACCA ATCACAATGACCATTCCGGTGCCCCCGCCCTCAGGAGAAGGTGTATCCAAT GGATACAAAGGGGACACTACACCCAATCTGCGTCTTCTCTGTAGCATTACA GGGGGCACTTCGCCTGCTCAGTGGGAAGACATCACAGGAACAACTCCTTTG ACGTTTATAAAAGATTGTGTCTCCTTTACAACCAATGTTTCAGCCAGATTTT GGCTTGCAGACTGCCATCAAGTTTTAGAAACTGTGGGGTTAGCCACGCAAC TGTACAGAGAATTGATATGTGTTCCATATATGGCCAAGTTTGTTGTTTTTGC CAAAATGAATGATCCCGTAGAATCTTCCTTGCGATGTTTCTGCATGACAGAT GACAAAGTGGACAAAACTTTAGAGCAACAAGAGAATTTTGAGGAAGTCGC AAGAAGCAAAGATATTGAGGTTCTGGAAGGAAAACCTATTTATGTTGATTG TTATGGAAATTTGGCCCCACTTACCAAAGGAGGACAGCAACTTGTTTTTAA CTTTTATTCTTTCAAAGAAAATAGACTGCCATTTTCCATCAAGATTAGAGAC ACCAGCCAAGAGCCCTGTGGTCGTCTGTCTTTTCTGAAAGAACCAAAGACA ACAAAAGGACTGCCTCAAACAGCGGTTTGCAACTTAAATATCACTCTGCCA GCACATAAAAAGGAGACAGAGTCAGATCAAGATGATGAGATTGAGAAAAC AGATAGACGACAGAGCTTCGCATCCTTAGCTTTACGTAAGCGCTACAGCTA CTTGACTGAGCCTGGAATGATTGAACGGAGTACAGGAGCAACAAGATCCCT CCCCACCACTTACTCATACAAGCCATTCTTTTCTACAAGACCATACCAGTCC TGGACAACAGCTCCGATTACAGTGCCTGGGCCAGCCAAGTCAGGCTTCACT TCCTTATCAAGTTCTTCCTCTAATACGCCATCAGCTTCTCCGTTAAAATCAA TATGGTCTGTTTCGACACCTTCTCCAATCAAATCCACATTAGGCGCGTCAAC TACATCTTCAGTTAAATCCATTAGTGACGTGGCATCTCCAATTAGATCCTTT CGGACAATGTCTTCGCCGATAAAAACTGTGGTGTCACAATCTCCATACAAT ATCCAAGTTTCCTCTGGTACCCTGGCTAGAGCTCCAGCAGTCACGGAAGCT ACGCCCTTAAAAGGGCTGGCATCCAATTCTACGTTTTCCTCTCGAACCTCTC CAGTGACTACAGCAGGGTCTCTTTTGGAGAGGTCATCAATTACTATGACAC CCCCTGCCTCCCCCAAATCAAACATTAATATGTATTCCTCAAGTTTGCCATT TAAGTCAATTATTACATCAGCAGCACCGCTAATATCTTCACCTTTAAAGTCA GTGGTGTCTCCAGTTAAATCAGCAGTTGATGTCATTTCATCAGCCAAAATTA CAATGGCATCTTCTCTCTCATCACCTGTGAAGCAGATGCCTGGACATGCAG AGGTAGCATTAGTCAATGGATCTATTTCCCCTCTAAAATATCCATCATCCTC AACTTTAATTAATGGATGCAAAGCCACTGCCACGTTACAGGAAAAAATTTC TTCTGCTACAAACTCTGTGAGCTCTGTGGTCAGTGCAGCCACTGACACAGTT GAGAAAGTGTTTTCTACCACGACTGCAATGCCATTTTCCCCACTCAGGTCAT ATGTTTCTGCAGCACCATCAGCTTTTCAGTCTCTAAGAACTCCTTCCGCAAG TGCACTCTATACATCCCTTGGGTCGTCAATATCTGCAACTACCTCATCTGTA ACTTCATCAATTATAACAGTGCCAGTATACTCTGTAGTCAATGTTTTGCCAG AACCAGCATTAAAGAAACTTCCAGACTCTAATTCATTTACAAAATCAGCAG CAGCCTTGCTGTCACCCATTAAAACATTGACTACGGAGACACATCCTCAGC CTCACTTCAGTCGAACTTCATCTCCAGTTAAGTCATCTTTGTTCCTTGCACCC TCTGCCCTTAAGTTGTCTACACCATCTTCTTTATCTTCCAGTCAGGAGATACT AAAAGATGTAGCTGAAATGAAAGAGGACCTAATGCGGATGACCGCAATAC TACAGACAGATGTGCCTGAGGAGAAGCCATTCCAACCTGAACTCCCAAAGG AAGGGAGAATAGATGATGAAGAACCTTTCAAAATTGTAGAGAAAGTAAAG GAAGACTTAGTGAAAGTTAGTGAAATCCTTAAAAAGGATGTATGTGTAGAT AATAAAGGATCACCCAAATCACCAAAGAGTGACAAAGGACACTCTCCTGA AGATGACTGGATAGAATTTAGTTCGGAAGAAATCCGGGAAGCCAGACAAC AAGCTGCTGCGAGCCAGTCTCCATCTCTGCCAGAGAGAGTGCAAGTAAAAG CAAAAGCCGCCTCCGAAAAGGATTATAACTTGACCAAAGTTATTGATTACC TAACAAATGATATTGGGAGTAGTTCACTGACAAACTTAAAATACAAGTTTG AGGATGCAAAGAAGGATGGTGAGGAGAGACAGAAAAGAGTTTTAAAACCA GCAATTGCTTTGCAGGAACACAAACTCAAAATGCCTCCAGCCTCCATGAGG ACTTCCACCTCTGAGAAAGAATTGTGTAAAATGGCTGATTCCTTTTTTGGAA CAGATACTATTTTAGAGTCTCCTGATGACTTTTCTCAACACGACCAAGATAA AAGTCCCTTGTCTGACAGTGGCTTTGAAACAAGAAGTGAAAAGACACCTTC AGCCCCACAAAGCGCTGAAAGCACTGGTCCTAAACCACTTTTTCATGAAGT TCCCATCCCTCCTGTCATTACAGAAACAAGAACTGAAGTGGTTCATGTTATC AGGAGCTATGATCCCTCAGCTGGGGATGTTCCCCAGACCCAACCAGAGGAG CCTGTGTCACCTAAACCTTCACCTACTTTTATGGAATTGGAACCAAAGCCCA CCACCTCTAGTATTAAAGAAAAGGTTAAAGCATTTCAAATGAAAGCCAGTA GTGAAGAAGATGACCACAATCGGGTTTTAAGCAAAGGCATGCGTGTTAAAG AAGAGACTCACATAACCACAACCACCAGAATGGTTTATCATTCTCCACCAG GCGGTGAAGGTGCATCTGAAAGAATTGAAGAAACCATGTCAGTCCATGACA TCATGAAGGCCTTTCAGTCCGGGCGGGATCCTTCCAAAGAACTGGCAGGTC TGTTTGAACATAAGTCGGCAGTGTCTCCAGATGTTCACAAGTCTGCTGCTGA AACCTCAGCCCAGCATGCAGAGAAGGACAACCAAATGAAACCCAAACTGG AGCGTATAATAGAAGTCCACATCGAAAAAGGTAACCAAGCTGAGCCCACT GAAGTCATTATTAGAGAAACCAAAAAGCATCCAGAAAAAGAAATGTATGT ATATCAGAAAGACTTATCCCGGGGAGATATTAACCTAAAAGATTTTCTGCC AGAAAAACACGATGCTTTTCCTTGTTCAGAGGAACAGGGTCAGCAAGAAGA AGAAGAACTTACTGCTGAAGAGTCATTGCCTTCTTATCTGGAGTCTTCCAGA GTAAACACTCCTGTGTCCCAAGAAGAAGATAGCCGCCCTAGTTCTGCTCAA CTCATATCTGATGACTCTTATAAAACATTGAAGCTTTTGAGTCAACACTCAA TAGAATACCATGACGATGAGTTGTCAGAACTAAGAGGGGAGTCTTACAGGT TTGCTGAGAAAATGCTTCTGTCAGAAAAGCTAGATGTGTCTCATTCTGATAC TGAGGAATCGGTTACAGACCATGCAGGACCCCCTAGCTCAGAGTTACAGGG GTCTGATAAGCGGTCCAGAGAAAAAATAGCCACTGCCCCCAAAAAAGAAA TTCTCTCCAAAATCTATAAAGATGTTTCTGAAAATGGTGTAGGTAAAGTGTC TAAAGATGAGCATTTTGATAAAGTGACAGTGTTGCACTATTCTGGCAATGTT AGTAGTCCAAAACATGCCATGTGGATGCGCTTTACTGAGGACAGATTAGAC AGAGGTAGAGAGAAGTTGATATATGAAGATAGGGTGGACAGGACTGTGAA GGAGGCTGAAGAAAAACTGACTGAAGTGTCACAGTTTTTTCGTGACAAAAC TGAAAAGCTAAATGATGAACTGCAGTCCCCAGAGAAAAAGGCACGCCCTA AAAATGGCAAAGAATATTCTTCTCAAAGCCCTACCAGTAGCAGCCCTGAGA AAGTGCTACTGACAGAACTGCTGGCATCCAATGATGAGTGGGTTAAGGCAA GACAGCATGGCCCTGATGGACAAGGCTTCCCCAAGGCCGAGGAGAAGGCA CCCAGTCTGCCCAGCAGCCCAGAGAAGATGGTTCTCTCCCAACAGACTGAG GACAGCAAGTCCACAGTGGAAGCCAAAGGAAGTATTTCACAGAGCAAAGC ACCAGATGGGCCCCAGTCTGGATTCCAGCTCAAACAATCTAAACTCAGTTC CATTAGATTAAAATTTGAACAAGGCACACACGCAAAAAGTAAGGACATGTC TCAAGAAGACAGAAAGTCAGATGGCCAGTCCAGAATCCCAGTTAAAAAAA TACAGGAGAGCAAGCTACCCGTCTACCAAGTTTTTGCTAGAGAAAAACAGC AGAAGGCCATAGACCTCCCAGATGAAAGTGTATCTGTGCAAAAAGATTTTA TGGTATTAAAAACCAAAGATGAGCATGCCCAAAGCAACGAAATTGTTGTAA ATGATTCTGGCTCTGATAATGTGAAAAAACAGAGAACTGAAATGTCAAGTA AAGCAATGCCTGACTCTTTTTCTGAGCAGCAGGCTAAAGACTTGGCATGTC ATATAACCTCAGATTTAGCAACTAGGGGACCATGGGACAAAAAGGTCTTTA GAACATGGGAGAGTTCGGGAGCCACTAACAATAAGTCTCAGAAAGAAAAA CTTTCGCATGTACTTGTTCATGATGTAAGAGAGAATCACATTGGTCACCCTG AGAGTAAAAGTGTTGATCAAAAGAATGAATTTATGTCTGTGACTGAGAGAG AACGCAAATTGTTAACAAACGGCTCTCTCTCAGAAATTAAAGAAATGACTG TAAAATCTCCCTCCAAAAAAGTCTTATATAGGGAATATGTTGTGAAAGAAG GGGACCATCCAGGCGGATTGCTTGATCAGCCTTCCAGGAGGAGCGAGAGCT CAGCAGTGTCACACATTCCCGTCAGAGTTGCTGATGAGAGGAGAATGCTGT CTTCTAATATTCCCGATGGTTTTTGTGAACAGTCGGCATTTCCAAAACATGA ACTATCACAAAAATTGTCCCAGTCAAGCATGAGTAAAGAGACAGTTGAGAC ACAGCACTTTAATTCTATAGAAGATGAAAAAGTTACCTATTCAGAAATCAG CAAAGTTTCCAAACACCAGAGTTATGTAGGTTTATGCCCACCTCTCGAGGA AACCGAAACCTCCCCCACCAAATCTCCTGATTCTTTAGAGTTTAGCCCAGGA AAGGAATCTCCCTCTAGTGATGTATTCGACCACAGTCCCATTGATGGATTGG AAAAACTCGCACCACTAGCCCAGACAGAGGGAGGGAAAGAGATAAAAACT TTACCCGTTTATGTCAGTTTTGTACAAGTGGGGAAGCAATATGAAAAGGAG ATACAACAAGGAGGTGTAAAAAAAATCATAAGTCAGGAATGTAAGACAGT ACAAGAAACCAGGGGGACCTTTTATACAACTAGACAGCAAAAGCAACCTC CTTCTCCCCAAGGTAGTCCAGAAGATGATACTCTAGAGCAAGTATCCTTTCT AGACAGCTCTGGGAAAAGCCCTTTAACCCCAGAAACACCCAGTTCAGAGGA AGTGAGTTATGAATTTACATCTAAGACACCTGACTCGCTCATAGCTTATATA CCAGGCAAACCCAGCCCAATTCCCGAGGTTTCTGAGGAGTCAGAGGAGGA GGAACAGGCCAAGTCAACCTCCCTTAAGCAGACTACAGTGGAGGAAACAG CAGTTGAGCGTGAAATGCCTAATGACGTGAGCAAAGACTCTAACCAAAGAC CCAAAAATAACAGAGTTGCCTATATTGAATTTCCCCCTCCTCCACCACTGGA TGCGGACCAGATTGAGTCAGATAAGAAGCATCATTATCTCCCAGAAAAAGA GGTTGACATGATTGAAGTCAATCTGCAAGATGAGCATGACAAGTACCAGCT GGCTGAACCTGTCATTAGAGTGCAGCCACCTTCACCAGTTCCTCCCGGGGC AGACGTCAGTGATTCAAGCGATGACGAATCTATTTATCAGCCAGTCCCAGT TAAAAAATATACCTTCAAATTAAAGGAAGTGGACGATGAACAAAAAGAAA AACCCAAAGCTTCTGCTGAAAAGGCTTCCAACCAGAAAGAACTGGAAAGT AATGGATCTGGAAAAGATAATGAATTTGGCCTTGGCCTTGATTCACCTCAG AATGAAATTGCCCAGAATGGGAACAACGACCAGTCCATCACAGAGTGTTCC ATTGCCACCACAGCAGAGTTTTCTCATGACACGGATGCCACAGAGATCGAC TCTCTGGATGGCTATGACCTGCAAGATGAAGATGATGGCTTGACAGAGAGT GATTCTAAACTCCCAATTCAAGCCATGGAAATTAAGAAAGATATCTGGAAC ACAGAGGGCATTCTGAAGCCAGCTGACCGCTCTTTTAGCCAAAGTAAACTT GAAGTTATCGAGGAGGAGGGAAAGGTGGGACCAGATGAGGACAAGCCACC TTCTAAAAGTTCTTCATCTGAAAAGACTCCTGATAAGACTGATCAGAAGTC AGGGGCCCAGTTCTTCACACTGGAAGGCAGACATCCTGACAGATCAGTGTT TCCTGATACTTACTTCAGTTACAAAGTAGATGAAGAATTTGCCACTCCTTTT AAAACAGTAGCTACCAAAGGTCTAGATTTTGACCCTTGGTCTAATAACCGA GGGGATGATGAAGTTTTTGACAGTAAATCACGGGAAGATGAAACTAAGCC ATTTGGGCTGGCGGTAGAAGACCGCTCTCCAGCAACAACCCCTGATACAAC GCCAGCCAGAACGCCAACTGATGAAAGTACCCCAACTAGTGAGCCTAACCC CTTCCCATTTCATGAAGGAAAAATGTTTGAGATGACTCGCAGTGGTGCAAT TGACATGAGCAAGAGGGATTTTGTTGAAGAGAGGCTCCAATTTTTCCAGAT TGGTGAGCATACTTCTGAAGGGAAGTCAGGGGACCAGGGGGAAGGGGATA AAAGTATGGTCACTGCCACACCACAGCCACAGTCAGGGGACACCACTGTAG AAACCAATCTAGAGAGAAATGTAGAGACACCTACAGTGGAACCTAACCCC AGCATCCCGACCAGCGGAGAGTGTCAGGAAGGCACATCCAGTAGTGGCTCC CTGGAGAAATCAGCAGCAGCCACTAACACCTCTAAAGTTGACCCCAAGTTG CGCACGCCTATAAAAATGGGAATTTCTGCATCCACCATGACCATGAAGAAA GAAGGCCCTGGAGAAATAACAGATAAGATAGAAGCGGTGATGACCAGTTG TCAGGGATTAGAAAATGAAACTATAACAATGATTTCAAATACAGCCAATAG CCAGATGGGCGTTAGGCCCCATGAAAAACATGATTTTCAAAAAGATAACTT TAATAACAACAACAATTTGGATTCTTCCACTATACAGACAGATAACATTAT GAGTAATATAGTTCTGACAGAACATTCTGCACCCACTTGTACCACAGAGAA AGATAACCCAGTGAAAGTCTCATCAGGAAAAAAGACAGGGGTACTACAAG GACACTGTGTAAGAGATAAGCAGAAAGTTCTTGGAGAACAGCAAAAAACA AAGGAATTGATAGGGATTAGGCAAAAATCCAAACTTCCCATAAAGGCCACT TCACCAAAAGATACCTTCCCACCGAACCATATGTCAAACACTAAAGCAAGT AAAATGAAGCAGGTTAGTCAATCCGAGAAAACCAAAGCCCTTACTACTTCT TCATGTGTAGATGTAAAGTCCAGAATTCCAGTGAAAAACACACACAGGGAT AACATAATTGCAGTTAGAAAAGCATGTGCCACACAAAAGCAAGGGCAGCC AGAGAAAGGCAAGGCCAAACAGCTTCCATCCAAGTTGCCAGTAAAGGTAA GATCCACCTGTGTCACTACCACCACCACCACTGCCACCACCACCACCACTA CCACCACTACCACCACCACCAGCTGCACAGTTAAAGTTAGGAAAAGTCAGC TCAAGGAAGTATGTAAACATTCCATTGAATATTTTAAGGGAATTAGTGGTG AGACCTTAAAGCTTGTGGACCGCCTCTCTGAAGAAGAAAAAAAGATGCAGT CCGAGTTGTCCGATGAGGAAGAAAGTACCTCAAGAAACACGTCGTTGTCCG AGACTTCCCGGGGTGGCCAGCCTTCGGTTACAACGAAGTCTGCTAGAGATA AGAAAACAGAGGCAGCACCTTTAAAATCAAAGAGTGAAAAGGCCGGCAGT GAGAAAAGGAGCAGTAGAAGGACTGGTCCACAGAGTCCATGTGAACGGAC AGATATCAGGATGGCAATAGTAGCCGATCACCTGGGACTTAGTTGGACAGA ACTGGCAAGGGAACTGAATTTTTCAGTGGATGAAATCAATCAAATACGTGT GGAAAATCCAAATTCTTTAATTTCTCAGAGCTTCATGTTATTAAAAAAATGG GTTACCAGAGACGGAAAAAATGCCACAACTGATGCCTTAACTTCGGTCTTG ACAAAAATTAATCGAATAGATATAGTGACACTGCTAGAAGGACCAATATTT GATTATGGAAATATTTCAGGCACCAGAAGTTTTGCAGATGAGAACAATGTT TTCCATGACCCTGTTGATGGTTGGCAGAATGAGACATCAAGTGGAAACCTA GAGTCCTGCGCTCAAGCTCGAAGAGTAACTGGTGGGTTACTAGATCGACTG GATGACAGCCCTGACCAGTGTAGAGATTCCATTACCTCATATCTCAAAGGA GAAGCTGGCAAATTTGAAGCAAATGGAAGCCATACAGAAATCACTCCAGA AGCAAAGACAAAATCTTACTTTCCAGAATCCCAAAATGATGTAGGAAAACA GAGTACCAAGGAAACTCTGAAACCAAAAATACATGGATCTGGTCATGTTGA AGAACCAGCATCACCACTAGCAGCATATCAGAAATCTCTAGAAGAAACCA GCAAGCTTATAATAGAAGAGACTAAACCCTGTGTGCCTGTCAGTATGAAAA AGATGAGTAGGACTTCTCCAGCAGATGGCAAGCCAAGGCTTAGCCTCCATG AAGAAGAGGGGTCCAGTGGGTCTGAGCAAAAGCAGGGAGAAGGTTTTAAG GTGAAAACGAAGAAAGAAATCCGGCATGTGGAAAAGAAGAGCCACTCGTA A THOC2-> ATGGCGGCCGCGGCTGTGGTGGTTCCCGCAGAGTGGATAAAGAACTGGGA SEQ ID DOCK11 GAAATCAGGGAGAGGCGAATTTTTGCATTTATGTCGGATCCTCAGTGAAAA NO:56 TAAAAGCCATGATAGTTCAACATACAGAGATTTCCAGCAAGCTCTCTATGA GTTGTCATATCATGTAATTAAAGGAAATCTAAAGCATGAACAGGCATCTAA TGTTCTTAGTGACATTAGTGAATTTCGTGAGGATATGCCCTCCATTCTTGCT GATGTATTCTGCATATTAGACATTGAGACAAATTGTTTAGAAGAAAAAAGC AAGAGAGACTATTTTACACAGTTGGTATTAGCATGTTTGTATTTAGTTTCAG ACACAGTTCTAAAGGAACGCCTGGATCCAGAAACACTGGAATCATTAGGGC TTATCAAACAATCACAGCAATTCAATCAAAAGTCAGTTAAAATCAAGACAA AACTCTTTTATAAGCAGCAAAAATTCAATTTGTTAAGAGAAGAGAATGAAG GTTATGCCAAGCTGATTGCTGAATTGGGGCAAGATTTATCTGGAAGTATTA CTAGTGATTTAATCTTAGAAAATATCAAATCTTTAATAGGATGCTTTAATCT GGATCCCAATAGAGTTTTGGATGTCATTTTAGAAGTGTTTGAATGCAGGCC AGAACACGATGACTTCTTTATATCTTTGTTAGAATCTTACATGAGTATGTGT GAACCGCAAACACTGTGTCATATTCTTGGGTTCAAATTCAAGTTTTACCAGG AACCAAATGGCGAGACACCATCATCTTTATACAGAGTTGCAGCAGTACTTC TACAATTTAATCTTATTGATTTAGATGATCTTTATGTACATCTTCTTCCGGCT GATAATTGCATTATGGATGAACACAAACGAGAAATTGCGGAAGCTAAGCA AATTGTTAGAAAGCTTACGATGGTTGTGTTGTCTTCTGAAAAAATGGATGA GCGAGAGAAAGAAAAGGAAAAAGAAGAGGAGAAAGTAGAGAAACCACCT GATAACCAAAAACTTGGCTTGTTGGAAGCCTTATTAAAGATTGGTGATTGG CAACATGCACAGAACATTATGGATCAGATGCCTCCATACTATGCAGCTTCA CACAAGCTAATAGCCCTTGCTATTTGCAAGCTCATTCATATAACTATTGAGC CTCTCTACCGAAGAGTTGGAGTTCCTAAAGGTGCTAAAGGCTCACCTGTTA ATGCTTTGCAAAACAAGAGAGCACCAAAACAAGCTGAGAGCTTTGAAGATT TGAGGAGAGACGTGTTCAATATGTTCTGTTACCTTGGTCCTCACCTTTCTCA CGATCCCATTTTATTTGCAAAAGTGGTGCGCATAGGCAAGTCATTTATGAA GGAGGAAAAGGCCAAAGTTGTTGAGCCCCTGGACTATGAGAATGTTATTGC CCAAAGAAAAACCCAGATTTACAGCGACCCCCTCCGAGATCTGCTTATGTT CCCAATGGAAGATATATCTATCTCGGTGATAGGTCGTCAACGCAGAACGGT GCAGTCTACTGTACCAGAAGATGCTGAAAAGAGGGCCCAGAGTTTATTTGT TAAAGAGTGTATTAAAACCTATAGCACAGATTGGCACGTGGTAAACTACAA GTATGAGGACTTCTCTGGGGACTTTCGAATGTTGCCATGTAAATCTTTGAGA CCAGAAAAGATTCCTAATCATGTATTTGAGATAGATGAAGACTGTGAGAAA GATGAGGACTCATCTTCTTTATGTTCTCAGAAGGGTGGTGTGATAAAACAA GGCTGGTTGCATAAAGCAAATGTAAATAGTACCATCACAGTAACCATGAAG GTATTCAAGAGACGATATTTTTACTTGACCCAACTTCCTGACGGTTCATATA TTCTCAATTCCTATAAAGATGAGAAAAATTCAAAAGAATCGAAAGGTTGCA TCTACTTGGACGCCTGCATTGATGTTGTTCAGTGCCCCAAAATGCGCCGTCA TGCTTTTGAACTCAAGATGTTAGATAAATATAGCCATTATCTGGCTGCTGAA ACTGAGCAGGAAATGGAGGAATGGTTGATAACTTTGAAAAAGATTATTCAG ATCAACACCGACAGTTTAGTTCAAGAAAAAAAGGAGACGGTAGAAACAGC ACAAGATGATGAAACTAGCAGCCAAGGAAAAGCCGAGAACATCATGGCAA GTTTGGAAAGGAGCATGCATCCGGAACTGATGAAGTATGGAAGAGAAACT GAACAACTAAACAAACTCAGTAGAGGAGATGGAAGACAGAATCTCTTTTCT TTTGATTCAGAAGTTCAGAGGTTGGACTTTTCAGGAATTGAACCTGATATAA AGCCATTTGAAGAAAAATGCAATAAACGTTTCCTGGTGAATTGCCATGATT TAACTTTCAATATCTTGGGCCAAATTGGAGACAATGCAAAAGGACCACCCA CAAATGTTGAGCCCTTTTTTATCAATCTTGCCTTATTTGATGTAAAGAACAA TTGTAAGATTTCAGCAGACTTTCATGTAGACCTGAATCCCCCATCTGTCCGT GAAATGCTGTGGGGCTCTTCAACCCAACTGGCCAGTGACGGTAGCCCAAAG GGCTCTTCACCCGAATCTTACATTCATGGAATTGCCGAATCTCAGTTACGCT ACATACAACAGGGAATTTTCTCAGTGACGAATCCACATCCTGAAATTTTTCT AGTTGCCAGAATTGAAAAGGTACTACAGGGAAACATTACACACTGTGCAGA ACCCTATATCAAAAATTCTGATCCAGTAAAGACGGCCCAGAAGGTGCACAG GACAGCTAAACAAGTGTGTAGCCGCCTTGGACAATACAGAATGCCCTTCGC TTGGGCTGCCAGACCCATTTTCAAAGATACTCAAGGCTCTCTTGATCTGGAT GGGAGATTTTCTCCTCTGTATAAACAAGACAGTAGCAAGCTTTCAAGTGAA GACATTCTCAAGTTGCTCTCAGAATATAAGAAGCCAGAAAAGACCAAACTG CAGATTATTCCTGGGCAGCTAAACATCACAGTAGAATGTGTTCCTGTGGATT TATCAAATTGTATTACTTCTTCATATGTGCCCTTGAAGCCTTTTGAAAAGAA TTGCCAAAATATTACTGTGGAGGTTGAAGAGTTTGTTCCAGAAATGACAAA ATATTGTTATCCATTTACTATTTACAAAAACCATCTGTATGTATATCCCCTG CAATTAAAATACGATAGCCAGAAAACATTTGCCAAGGCAAGGAACATTGC AGTCTGTGTGGAATTCCGGGATTCAGATGAAAGTGACGCTAGTGCCCTAAA GTGTATTTATGGAAAACCTGCAGGGTCTGTTTTTACCACAAATGCTTATGCT GTTGTCTCGCATCACAACCAAAATCCAGAGTTCTATGATGAGATTAAAATT GAGCTTCCCATTCACCTACATCAAAAACATCATTTGCTTTTCACTTTTTATCA TGTAAGTTGTGAAATTAACACAAAGGGAACAACCAAAAAGCAAGACACAG TTGAAACTCCAGTTGGGTTTGCCTGGGTACCTTTGCTGAAAGATGGTAGAAT CATCACATTTGAGCAGCAGCTGCCAGTTTCCGCCAATCTTCCCCCAGGCTAC TTGAATCTGAATGATGCAGAATCAAGAAGGCAATGTAACGTGGATATTAAA TGGGTAGATGGTGCAAAGCCTTTGTTGAAGATTAAAAGCCACTTAGAATCT ACCATTTACACTCAAGATCTGCATGTGCACAAATTCTTCCATCATTGCCAGC TGATTCAGTCAGGCTCGAAAGAAGTTCCAGGGGAGCTCATTAAATATTTAA AGTGTTTGCATGCCATGGAGATCCAAGTCATGATACAGTTTCTACCTGTAAT TCTTATGCAACTCTTCCGAGTTCTCACAAATATGACCCATGAAGATGACGTT CCTATCAACTGCACCATGGTTCTCTTACATATTGTATCAAAGTGCCATGAAG AAGGCTTGGATAGTTATCTAAGATCATTCATAAAGTATAGCTTCCGACCTG AAAAACCGAGTGCTCCTCAGGCCCAGCTGATACATGAAACCCTGGCTACTA CGATGATAGCAATATTGAAACAGTCTGCAGATTTTTTATCAATAAACAAAT TGCTAAAGTACTCATGGTTTTTCTTTGAAATAATTGCAAAGTCAATGGCCAC ATACTTGTTGGAAGAGAATAAGATTAAGCTTCCCCGAGGCCAGAGATTTCC CGAGACATATCATCATGTCTTACATTCACTGCTTCTTGCAATAATTCCCCAT GTGACTATTCGGTATGCGGAGATTCCCGATGAGTCCAGAAATGTGAACTAT AGTTTGGCTAGCTTCCTGAAGCGCTGTTTGACACTAATGGATAGAGGATTTA TTTTCAATTTAATAAATGACTATATATCTGGATTCAGCCCCAAAGATCCTAA GGTTCTGGCTGAATACAAGTTTGAATTTCTGCAAACAATTTGCAATCACGA ACATTACATTCCTCTGAACTTGCCAATGGCATTTGCAAAACCTAAACTGCAG CGGGTTCAAGATTCAAATCTTGAATACAGTTTATCAGATGAGTATTGCAAG CATCACTTCTTGGTTGGTCTACTTCTGAGGGAAACTTCCATTGCTCTTCAGG ACAATTATGAGATCAGATATACAGCTATCTCTGTTATAAAGAATCTTTTGAT AAAACATGCATTTGACACAAGATACCAGCACAAGAACCAACAAGCCAAAA TAGCACAATTGTACCTCCCCTTTGTTGGACTACTTTTGGAAAATATACAGCG ATTAGCAGGTCGAGATACCTTGTATTCTTGTGCAGCCATGCCTAATTCTGCA TCCAGAGATGAGTTTCCATGTGGCTTTACTTCACCTGCCAATAGAGGGAGTC TGAGCACTGACAAAGACACCGCTTATGGGTCTTTTCAAAATGGACATGGAA TTAAGAGAGAAGATTCAAGAGGTTCCCTCATCCCAGAAGGAGCAACAGGA TTTCCAGATCAGGGCAACACTGGTGAAAATACCCGACAGAGTTCTACAAGG AGTAGTGTATCCCAGTATAACCGCCTGGATCAGTATGAAATCAGAAGCCTC CTGATGTGCTACCTGTATATAGTAAAAATGATTTCAGAAGATACTCTCTTAA CTTACTGGAATAAAGTATCACCTCAGGAGCTCATAAACATTCTTATACTTTT AGAAGTATGCTTGTTTCACTTTAGATATATGGGGAAAAGAAACATAGCAAG GGTGCATGATGCCTGGCTGTCAAAACACTTCGGAATAGACCGAAAATCGCA AACCATGCCTGCTCTTCGAAACAGATCAGGAGTAATGCAGGCCCGGCTTCA GCATCTTAGTAGCCTAGAAAGTTCATTTACACTTAATCACAGTTCTACAACA ACTGAAGCAGACATTTTCCACCAGGCACTTCTTGAAGGCAATACAGCTACT GAAGTTTCCCTAACAGTACTAGACACCATATCATTTTTCACTCAGTGCTTCA AGACCCAACTTTTAAATAATGATGGCCATAACCCATTAATGAAAAAAGTGT TTGATATACATCTTGCTTTTCTTAAAAATGGACAATCTGAAGTGTCGCTGAA ACATGTATTTGCCTCACTGAGAGCTTTCATCAGTAAGTTTCCTTCAGCATTT TTCAAAGGAAGAGTAAACATGTGTGCTGCATTTTGCTATGAGGTTTTAAAG TGCTGCACATCGAAGATTAGCTCAACCAGGAATGAAGCATCTGCACTTTTG TATCTTTTGATGAGAAACAACTTTGAGTATACCAAAAGGAAAACCTTTTTG AGGACACATCTACAGATAATAATTGCTGTAAGCCAACTGATAGCTGATGTA GCACTAAGCGGAGGATCAAGATTTCAGGAGTCTTTATTCATTATCAATAATT TTGCAAATAGTGACAGACCTATGAAGGCAACTGCCTTTCCCGCAGAAGTCA AAGACTTGACCAAGAGAATCCGCACTGTTCTTATGGCCACTGCCCAAATGA AGGAGCATGAGAAAGACCCTGAAATGCTAATTGATCTCCAGTATAGCTTAG CCAAGTCCTATGCAAGCACCCCAGAGCTCAGGAAAACCTGGCTTGATAGCA TGGCCAAGATTCATGTAAAAAATGGAGATTTTTCAGAGGCTGCGATGTGTT ATGTCCATGTAGCAGCTCTAGTTGCAGAGTTTCTTCATCGAAAAAAATTATT TCCTAACGGATGTTCAGCGTTCAAGAAAATTACTCCCAATATAGATGAAGA AGGAGCAATGAAAGAAGATGCTGGGATGATGGATGTCCATTATAGTGAAG AGGTCTTGCTGGAGTTGCTAGAACAATGTGTGGATGGCTTATGGAAGGCAG AACGTTATGAAATAATTTCTGAGATTTCCAAGTTGATCGTTCCAATTTATGA GAAACGTCGTGAGTTTGAGAAACTTACTCAAGTTTATAGAACTCTTCATGG AGCTTACACAAAAATTCTGGAAGTTATGCATACAAAAAAGAGACTTTTAGG CACTTTCTTCAGAGTTGCCTTTTATGGCCAATCTTTTTTTGAAGAAGAAGAT GGAAAGGAGTACATCTATAAAGAACCAAAGCTCACTGGCCTCTCAGAAATT TCCTTGAGACTTGTTAAACTTTATGGTGAAAAGTTTGGTACGGAGAATGTCA AAATAATTCAGGATTCAGACAAGGTAAATGCCAAAGAGCTTGATCCAAAAT ATGCTCATATACAAGTTACTTATGTGAAGCCTTACTTTGATGACAAAGAACT CACAGAAAGGAAGACCGAGTTTGAAAGAAATCATAATATCAGCAGATTTGT TTTTGAGGCCCCTTACACTTTATCAGGCAAAAAACAGGGCTGTATAGAAGA ACAGTGCAAACGCCGTACAATCTTGACAACTTCAAACTCGTTTCCTTACGTG AAGAAGAGGATTCCTATTAACTGTGAACAGCAGATTAATTTAAAACCAATT GATGTTGCCACTGATGAAATAAAAGATAAAACTGCAGAGCTGCAAAAGCTT TGCTCCTCTACTGACGTGGACATGATTCAGCTCCAACTTAAATTGCAGGGCT GTGTTTCTGTGCAGGTCAATGCTGGTCCATTAGCATATGCAAGAGCTTTCTT AAATGACAGCCAAGCTAGCAAGTATCCACCTAAGAAAGTGAGTGAGTTGA AAGACATGTTTAGGAAATTTATACAAGCATGCAGCATTGCACTTGAACTAA ATGAGCGGCTAATTAAAGAAGATCAAGTTGAGTACCATGAAGGGCTAAAG TCAAATTTCAGAGACATGGTAAAAGAATTATCTGACATTATCCATGAGCAG ATATTACAAGAAGACACAATGCATTCTCCCTGGATGAGCAACACATTACAT GTATTTTGTGCAATTAGTGGTACATCAAGTGACCGAGGTTATGGTTCCCCAA GATACGCTGAAGTGTGA AFl -> CAGAATCGGAGAGCCGGTGGCGTCGCAGGTCGGGAGGACGAGCACCGAGT SEQ ID NKIRAS1 CGAGGGCTCGCTCGTCTGGGCCGCCCGAGAGTCTTAATCGCGGGCGCTTGG NO:57 GCCGCCATCTTAGATGGCGGGAGTAAGAGGAAAACGATTGTGAGGCGGGA ACGGCTTTCTGCTGCCTTTTTTGGGCCCCGAAAAGGGTCAGCTGGCCGGGCT TTGGGGCGCGTGCCCTGAGGCGCGGAGCGCGTTTGCTACGATGCGGGGGCT GCTCGGGGCTCCGTCCCCTGGGCTGGGGACGCGCCGAATGTGACCGCCTCC CGCTCCCTCACCCGCCGCGGGGAGGAGGAGCGGGCGAGAAGCTGCCGCCG AACGACAGGACGTTGGGGCGGCCTGGCTCCCTCAGGAATGGAAGATTGCG AAACAATGGAAGATGTATACATGGCTTCAGTAGAAACAGACCGAGGAGTA AAAGAACAGTTACATCTTTATGACACCAGAGGTCTACAGGAAGGCGTGGAG CTGCCAAAGCATTATTTTTCATTTGCTGATGGCTTCGTTCTTGTGTACAGTGT GAATAACCTTGAATCCTTTCAAAGAGTGGAGCTTCTGAAGAAAGAAATCGA TAAGTTCAAAGACAAAAAAGAGGTAGCAATTGTGGTATTAGGAAACAAAA TCGACCTTTCTGAGCAGAGACAAGTGGACGCTGAAGTGGCACAGCAGTGGG CAAAAAGTGAGAAAGTAAGACTGTGGGAGGTGACTGTTACAGATCGGAAA ACTCTGATTGAACCATTCACTTTATTAGCCAGTAAACTTTCTCAACCCCAGA GCAAATCAAGCTTTCCTTTGCCTGGGAGGAAAAACAAAGGGAACTCTAATT CTGAGAACTAAAAATCAGTAATTTCCACAATTGTATGTTGAATAGTGATTG CCTTTAAGTGTCTGTGAACATGGAGTAATATTACTATTTAAAATAGGCCATT TGTATCTACCTTTGGTCCTTAGGAAAATTCCTAAGGAAGTCAATTAATGCAC TTTAGATGTTAAAAGTATTTGGGCTAAGGTTATTATTGCCTGATATGAAATA ATATATTCTTATTCTCATTGTTTGAAACCTGTCTTTGAAATTAGCACCTTTGT TATTTATGTTGTACTTGTGAAAACAGTAAAATAGTTTGGATAGTTATGCAAA TGCACCTATGTGTAACTTCCCCCCAACCCCAAGCTGTTTCGGAAGATATCAT AATCATTCTGTGTAACATTATGCAAACTTCTAAGCCCAAACATGACTTTGTT TTTAAAAAGTTCATTAATCTAATGTCTAGGATTATAAAACATTTTTTTGTGT CTAAATTGGACCCAAAACATTGAACAGTTTGGGGTAGTAAGCTAAATTTCA TCTTGTGGAGATTTTGCTAAACAGACTAAGACCCATGATTTAGCTTTGCTCA AATTAGAATGTTTAGCATGAGTTGAGGTACCAGGTAGTGTTAAGTAGGTTC ATCACGCTCTAAGGCCGTTTTTTCCTTAGCCAGACCCCTGTTGATAGACCAG ATACTTGAGGGCAAACTGTTTGCTCCTCCTCTTGAAAATGATTAGGCACTTA AGGACAGTAAAGCTGTATTTTCTGGAAGGAAGACTGTATCTTCTGGAATAG TTTTCTAGAAAACTAGTCATATACAATAAAAGTATCAAAAATATTGGGCTC TAATTTGATCTGACTTAGATGTCTGAGTTTGTGTTGTTTCTCTAAAGATTTTG GCAAGACTCAAGCAATGTGGCTGACTGTAACTTTATTAATTTAAAAGGTAG GAAGTAAGCTACTTAGTGGTTTCACCTGTGAAATAACTATTTTGACTGAAAT GTAAAATAAGCTATTCAACAAAGAACATATTAAAACATCAA ΖΕΒ 1-> ATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCG SEQ ID PLEKHF2 CAATAACGATGGTGGATCGCTTGGCAAACAGTGAAGCAAATACTAGACGTA NO:58 TAAGTATAGTGGAAAACTGTTTTGGAGCAGCTGGTCAACCTTTAACTATAC CTGGACGAGTTCTTATTGGAGAAGGAGTATTGACTAAGTTGTGCAGGAAAA AGCCCAAAGCAAGGCAGTTTTTCTTGTTTAATGATATTCTTGTATATGGCAA TATTGTCATCCAGAAGAAAAAATATAACAAACAACATATTATTCCCCTGGA AAATGTCACTATTGATTCCATCAAAGATGAGGGAGACTTAAGGAATGGATG GCTAATCAAGACACCAACTAAATCTTTTGCAGTTTATGCTGCCACTGCTACG GAGAAATCAGAATGGATGAATCATATAAATAAATGTGTTACTGATTTACTC TCCAAAAGTGGGAAGACACCCAGTAATGAACATGCTGCTGTCTGGGTTCCT GACTCTGAGGCAACTGTATGTATGCGTTGTCAGAAAGCAAAATTCACACCT GTTAATCGTCGCCACCATTGCCGCAAATGTGGTTTTGTTGTCTGTGGGCCCT GCTCTGAAAAGAGATTTCTTCTTCCCAGCCAGTCCTCTAAGCCTGTGCGGAT TTGTGACTTCTGCTATGACCTGCTTTCTGCTGGGGACATGGCCACATGCCAG CCTGCTAGATCAGACTCTTACAGCCAGTCATTGAAGTCTCCTTTAAATGATA TGTCTGATGATGATGACGATGATGATAGCAGTGACTAA PPP1R12 ATGTCCGGAGAGGATGGCCCGGCGGCTGGCCCGGGGGCGGCGGCGGCGGC SEQ ID C-> TGCCCGGGAGCGGCGACGGGAGCAGCTGCGGCAGTGGGGGGCGCGGGCGG NO:59 IFITM10 GCGCCGAGCCTGGCCCCGGAGAGCGCCGCGCCCGCACCGTCCGCTTCGAGC GCGCCGCCGAGTTCCTGGCGGCCTGTGCGGGCGGCGACCTGGACGAGGCGC GTCTGATGCTGCGCGCCGCCGACCCTGGCCCCGGCGCCGAGCTCGACCCCG CCGCGCCGCCGCCCGCCCGCGCCGTGCTGGACTCCACCAACGCCGACGGTA TCAGCGCCCTGCACCAGGCCTGCATTGATGAGAACCTGGAGGTGGTGCGCT TCTTGGTGGAGCAGGGCGCCACTGTGAACCAGGCAGACAACGAGGGCTGG ACGCCACTGCACGTGGCCGCCTCCTGTGGCTACCTAGATATCGCCAGGTAC CTCCTGAGCCACGGGGCCAACATCGCCGCCGTCAACAGTGACGGGGACCTG CCCCTGGACCTGGCCGAGTCGGACGCCATGGAGGGGCTGCTGAAGGCGGA GATCGCCCGCCGAGGTGTGGATGTGGAAGCAGCCAAGCGGGCAGAAGAGG AATTGCTCCTTCATGACACGAGGTGCTGGCTGAATGGGGGCGCCATGCCAG AGGCCCGGCACCCCCGCACAGGCGCCTCTGCCCTGCACGTGGCTGCTGCCA AGGGCTACATTGAGGTGATGAGGTTGCTCCTTCAGGCTGGCTACGACCCAG AGCTCCGGGACGGGGACGGCTGGACTCCCCTGCACGCAGCGGCACACTGG GGCGTGGAGGATGCCTGCCGCCTGCTGGCCGAGCATGGCGGGGGCATGGA CTCACTGACCCATGCGGGGCAGCGTCCCTGTGACCTGGCCGATGAGGAAGT ACTGAGCCTGTTGGAGGAACTGGCCCGGAAACAGGAGGACGCCCAGGGCC CCGGCCAGTGCCCAGCCCCGCTGGGAGACCCGGCCAGCACCACGGACGGC GCCCAGGAAGCCCGAGTCCCCCTGGACGGGGCCTTCTGGATTCCGAGGCCC CCGGCAGGTTCGCCCAAGGGCTGCTTCGCTTGCGTGTCCAAGCCCCCTGCC CTGCAGGCTCCGGCGGCCCCTGCCCCTGAGCCCTCGGCCTCTCCCCCGATG GCGCCCACACTGTTCCCCATGGAGTCCAAGAGCAGCAAGACCGACAGCGTG CGGGCTGCCGGCGCGCCCCCTGCCTGCAAGCACCTAGCCGAGAAGAAGAC GATGACCAACCCCACGACCGTCATCGAGGTCTACCCGGACACCACCGAGGT GAACGACTATTACCTGTGGTCCATCTTCAACTTCGTCTACCTCAACTTCTGC TGCCTGGGCTTCATCGCCTTGGCCTACTCCCTCAAAGTGCGAGACAAGAAG CTTCTCAATGACCTGAATGGAGCCGTGGAGGATGCAAAGACGGCCCGGCTG TTCAACATCACCAGTTCTGCCCTGGCAGCCTCCTGCATCATCCTCGTCTTCA TCTTCCTGCGGTACCCCCTCACCGACTACTAA CEP152-> ATGTCATTAGACTTTGGCAGTGTGGCACTACCAGTGCAAAATGAAGATGAA SEQ ID IQGAP1 GAGTATGACGAAGAGGACTATGAAAGAGAGAAAGAGTTGCAGCAGTTACT NO: 60 CACAGACCTTCCCCATGACATGCTGGATGACGACCTCTCCTCTCCAGAGCTC CAGTATTCGGACTGCAGCGAGGATGGCACAGACGGACAACCACATCATCCT GAGCAATTGGAGATGAGCTGGAATGAGCAAATGCTGCCCAAATCTCAAAGT GTAAATGGCTATAATGAAATTCAGAGTTTATATGCTGGAGAAAAATGTGGT AATGTCTGGGAAGAAAATAGAAGTAAAACTGAAGACCGACATCCTGTGTA CCATCCTGAAGAAGGTGGAGATGAAGGTGGAAGTGGTTATAGTCCTCCAAG TAAATGTGAACAGACTGATTTATATCACCTTCCTGAAAACTTTAGGCCATAT ACCAATGGTCAGAAGCAGGAATTTAATAACCAAGCAACCAATGTAATTAAA TTTTCAGATCCTCAATGGAACCATTTTCAGGGTCCCAGTTGTCAAGGTTTGG AACCGTATAATAAAGTGACATATAAACCTTATCAGTCTTCTGCCCAGAATA ATGGCTCACCAGCCCAGGAGATAACAGGAAGTGACACATTCGAAGGCCTG CAACAACAATTTTTAGGAGCTAATGAGAACTCTGCAGAAAATATGCAGATT ATTCAACTTCAGGTTCTTAACAAAGCAAAAGAGAGACAACTGGAGAACTTA ATTGAAAAGTTAAATGAAAGTGAACGTCAAATTCGATATCTGAATCACCAG CTTGTAATAATAAAAGATGAAAAGGATGGTTTGACTCTCAGCCTTCGAGAA TCACAGAAACTCTTTCAGAATGGAAAAGAAAGAGAGATACAGCTTGAAGC TCAAATAAAAGCACTGGAGACTCAGATACAAGCATTAAAAGTCAATGAAG AACAGATGATCAAGAAGTCCAGAACAACTGAAATGGCTCTGGAAAGCTTG AAGCAGCAGCTGGTGGACCTTCATCATTCTGAATCACTTCAACGAGCTAGA GAACAGCATGAGAGCATTGTTATGGGCCTCACAAAGAAGTACGAAGAGCA AGTATTGTCCTTACAAAAGAATTTGGATGCCACAGTCACCGCACTTAAAGA ACAGGAAGACATTTGCTCTCGTCTGAAAGATCACGTGAAACAACTGGAAAG GAATCAAGAAGCAATCAAGTTAGAAAAGACTGAGATCATTAATAAGTTGA CAAGAAGTCTAGAGGAGAGTCAAAAGCAGTGTGCCCACTTGTTGCAGTCCG GGTCAGTACAAGAGGTGGCTCAGCTACAGTTCCAGCTGCAGCAAGCACAGA AGGCACATGCTATGAGTGCAAACATGAACAAGGCTTTGCAAGAAGAATTA ACAGAACTAAAAGATGAAATTTCTCTCTATGAATCTGCTGCAAAACTAGGA ATACATCCAAGTGACTCAGAAGGAGAATTAAATATAGAACTCACTGAATCG TATGTGGATTTGGGTATTAAAAAGGTCAACTGGAAAAAATCCAAAGTTACC AGCATTGTACAAGAAGAAGACCCAAATGAAGAGCTTTCAAAAGATGAGTT CATTCTGAAGTTAAAGGCAGAAGTACAGCGTTTGCTGGGTAGCAACTCAAT GAAGCGTCATCTGGTGTCTCAGTTACAAAATGACCTCAAAGACTGTCATAA GAAAATTGAAGATCTCCACCAAGTGAAGAAGGATGAAAAAAGCATTGAGG TTGAGACTAAAACAGATACCTCAGAAAAACCAAAGAATCAATTATGGCCTG AGTCTTCTACTTCTGATGTTGTCAGAGATGATATTCTGCTGCTTAAAAATGA AATTCAAGTTTTACAACAACAAAATCAGGAACTTAAAGAAACTGAAGGAA AACTGAGAAATACAAATCAAGACTTATGTAATCAAATGAGACAAATGGTAC AAGATTTTGACCATGACAAACAAGAAGCTGTGGATAGGTGTGAAAGGACTT ATCAGCAGCACCATGAAGCCATGAAAACTCAAATACGTGAAAGCCTATTAG CAAAGCATGCTTTGGAGAAGCAGCAGCTCTTTGAGGCTTATGAGAGAACTC ATTTGCAACTGAGGTCTGAGTTGGATAAGTTGAATAAGGAGGTGACTGCTG TGCAGGAATGTTACCTAGAAGTGTGCAGAGAGAAGGATAATCTAGAATTGA CTCTCAGGAAGACCACTGAAAAGGAGCAACAGACTCAGGAGAAGATTTTTT ACCCAGAAACTACAGATATCTATGATCGAAAGAACATGCCAAGATGTATCT ACTGTATCCATGCACTCAGTTTGTACCTGTTCAAGCTAGGCCTGGCCCCTCA GATTCAAGACCTATATGGAAAGGTTGACTTCACAGAAGAAGAAATCAACA ACATGAAGACTGAGTTGGAGAAGTATGGCATCCAGATGCCTGCCTTTAGCA AGATTGGGGGCATCTTGGCTAATGAACTGTCAGTGGATGAAGCCGCATTAC ATGCTGCTGTTATTGCTATTAATGAAGCTATTGACCGTAGAATTCCAGCCGA CACATTTGCAGCTTTGAAAAATCCGAATGCCATGCTTGTAAATCTTGAAGA GCCCTTGGCATCCACTTACCAGGATATACTTTACCAGGCTAAGCAGGACAA AATGACAAATGCTAAAAACAGGACAGAAAACTCAGAGAGAGAAAGAGATG TTTATGAGGAGCTGCTCACGCAAGCTGAAATTCAAGGCAATATAAACAAAG TCAATACATTTTCTGCATTAGCAAATATCGACCTGGCTTTAGAACAAGGAG ATGCACTGGCCTTGTTCAGGGCTCTGCAGTCACCAGCCCTGGGGCTTCGAG GACTGCAGCAACAGAATAGCGACTGGTACTTGAAGCAGCTCCTGAGTGATA AACAGCAGAAGAGACAGAGTGGTCAGACTGACCCCCTGCAGAAGGAGGAG CTGCAGTCTGGAGTGGATGCTGCAAACAGTGCTGCCCAGCAATATCAGAGA AGATTGGCAGCAGTAGCACTGATTAATGCTGCAATCCAGAAGGGTGTTGCT GAGAAGACTGTTTTGGAACTGATGAATCCCGAAGCCCAGCTGCCCCAGGTG TATCCATTTGCCGCCGATCTCTATCAGAAGGAGCTGGCTACCCTGCAGCGA CAAAGTCCTGAACATAATCTCACCCACCCAGAGCTCTCTGTCGCAGTGGAG ATGTTGTCATCGGTGGCCCTGATCAACAGGGCATTGGAATCAGGAGATGTG AATACAGTGTGGAAGCAATTGAGCAGTTCAGTTACTGGTCTTACCAATATT GAGGAAGAAAACTGTCAGAGGTATCTCGATGAGTTGATGAAACTGAAGGC TCAGGCACATGCAGAGAATAATGAATTCATTACATGGAATGATATCCAAGC TTGCGTGGACCATGTGAACCTGGTGGTGCAAGAGGAACATGAGAGGATTTT AGCCATTGGTTTAATTAATGAAGCCCTGGATGAAGGTGATGCCCAAAAGAC TCTGCAGGCCCTACAGATTCCTGCAGCTAAACTTGAGGGAGTCCTTGCAGA AGTGGCCCAGCATTACCAAGACACGCTGATTAGAGCGAAGAGAGAGAAAG CCCAGGAAATCCAGGATGAGTCAGCTGTGTTATGGTTGGATGAAATTCAAG GTGGAATCTGGCAGTCCAACAAAGACACCCAAGAAGCACAGAAGTTTGCCT TAGGAATCTTTGCCATTAATGAGGCAGTAGAAAGTGGTGATGTTGGCAAAA CACTGAGTGCCCTTCGCTCCCCTGATGTTGGCTTGTATGGAGTCATCCCTGA GTGTGGTGAAACTTACCACAGTGATCTTGCTGAAGCCAAGAAGAAAAAACT GGCAGTAGGAGATAATAACAGCAAGTGGGTGAAGCACTGGGTAAAAGGTG GATATTATTATTACCACAATCTGGAGACCCAGGAAGGAGGATGGGATGAAC CTCCAAATTTTGTGCAAAATTCTATGCAGCTTTCTCGGGAGGAGATCCAGA GTTCTATCTCTGGGGTGACTGCCGCATATAACCGAGAACAGCTGTGGCTGG CCAATGAAGGCCTGATCACCAGGCTGCAGGCTCGCTGCCGTGGATACTTAG TTCGACAGGAATTCCGATCCAGGATGAATTTCCTGAAGAAACAAATCCCTG CCATCACCTGCATTCAGTCACAGTGGAGAGGATACAAGCAGAAGAAGGCA TATCAAGATCGGTTAGCTTACCTGCGCTCCCACAAAGATGAAGTTGTAAAG ATTCAGTCCCTGGCAAGGATGCACCAAGCTCGAAAGCGCTATCGAGATCGC CTGCAGTACTTCCGGGACCATATAAATGACATTATCAAAATCCAGGCTTTTA TTCGGGCAAACAAAGCTCGGGATGACTACAAGACTCTCATCAATGCTGAGG ATCCTCCTATGGTTGTGGTCCGAAAATTTGTCCACCTGCTGGACCAAAGTGA CCAGGATTTTCAGGAGGAGCTTGACCTTATGAAGATGCGGGAAGAGGTTAT CACCCTCATTCGTTCTAACCAGCAGCTGGAGAATGACCTCAATCTCATGGAT ATCAAAATTGGACTGCTAGTGAAAAATAAGATTACGTTGCAGGATGTGGTT TCCCACAGTAAAAAACTTACCAAAAAAAATAAGGAACAGTTGTCTGATATG ATGATGATAAATAAACAGAAGGGAGGTCTCAAGGCTTTGAGCAAGGAGAA GAGAGAGAAGTTGGAAGCTTACCAGCACCTGTTTTATTTATTGCAAACCAA TCCCACCTATCTGGCCAAGCTCATTTTTCAGATGCCCCAGAACAAGTCCACC AAGTTCATGGACTCTGTAATCTTCACACTCTACAACTACGCGTCCAACCAGC GAGAGGAGTACCTGCTCCTGCGGCTCTTTAAGACAGCACTCCAAGAGGAAA TCAAGTCGAAGGTAGATCAGATTCAAGAGATTGTGACAGGAAATCCTACGG TTATTAAAATGGTTGTAAGTTTCAACCGTGGTGCCCGTGGCCAGAATGCCCT GAGACAGATCTTGGCCCCAGTCGTGAAGGAAATTATGGATGACAAATCTCT CAACATCAAAACTGACCCTGTGGATATTTACAAATCTTGGGTTAATCAGAT GGAGTCTCAGACAGGAGAGGCAAGCAAACTGCCCTATGATGTGACCCCTGA GCAGGCGCTAGCTCATGAAGAAGTGAAGACACGGCTAGACAGCTCCATCA GGAACATGCGGGCTGTGACAGACAAGTTTCTCTCAGCCATTGTCAGCTCTG TGGACAAAATCCCTTATGGGATGCGCTTCATTGCCAAAGTGCTGAAGGACT CGTTGCATGAGAAGTTCCCTGATGCTGGTGAGGATGAGCTGCTGAAGATTA TTGGTAACTTGCTTTATTATCGATACATGAATCCAGCCATTGTTGCTCCTGA TGCCTTTGACATCATTGACCTGTCAGCAGGAGGCCAGCTTACCACAGACCA ACGCCGAAATCTGGGCTCCATTGCAAAAATGCTTCAGCATGCTGCTTCCAA TAAGATGTTTCTGGGAGATAATGCCCACTTAAGCATCATTAATGAATATCTT TCCCAGTCCTACCAGAAATTCAGACGGTTTTTCCAAACTGCTTGTGATGTCC CAGAGCTTCAGGATAAATTTAATGTGGATGAGTACTCTGATTTAGTAACCCT CACCAAACCAGTAATCTACATTTCCATTGGTGAAATCATCAACACCCACAC TCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATC CACGAACTGCTGGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATA GGGGAAAGCTCTGGCAATTTAAATGACCCAAATAAGGAGGCACTGGCTAA GACGGAAGTGTCTCTCACCCTGACCAACAAGTTCGACGTGCCTGGAGATGA GAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGTTTAAT TGTGGATGTCATCCGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTAGA AACACCAGCCACCAGTGAACAGGAAGCAGAACATCAGAGAGCCATGCAGA GACGTGCTATCCGTGATGCCAAAACACCTGACAAGATGAAAAAGTCAAAAT CTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAGAAGAAAGAGAAGATC CAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGAA CAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCG GAGGTACCGACAGAGGAGAAAGGCCGAACTAGTGAAACTGCAACAGACAT ACGCTGCTCTGAACTCTAAGGCCACCTTTTATGGGGAGCAGGTGGATTACT ATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCAGCAAGGGCAAAG TCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCT CTGAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATT GAGGACCTGCAAGTGAATCAGTTTAAAAATGTTATATTTGAAATCAGTCCA ACAGAAGAAGTTGGAGACTTCGAAGTGAAAGCCAAATTCATGGGAGTTCA AATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCTACAGTATGA AGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCT CCTGATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAA SLC19A2 ATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCGGCGGCGGCGGCGGCCACT SEQ ID -> GTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCG NO: 6 1 NAA50 CGCTGCTCTGCGCCTACGGCTTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTT CCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGT AGCCGGATCGAGCTGGGAGATGTGACACCACACAATATTAAACAGTTGAA AAGATTGAATCAGGTCATCTTTCCAGTCAGCTACAATGACAAGTTCTACAA GGATGTGCTGGAGGTTGGCGAGCTAGCAAAACTTGCCTATTTCAATGATAT TGCTGTAGGTGCAGTATGCTGTAGGGTGGATCATTCACAGAATCAGAAGAG ACTTTACATCATGACACTAGGATGTCTGGCACCTTACCGAAGGCTAGGAAT AGGAACTAAAATGTTAAATCATGTCTTAAACATCTGTGAAAAAGATGGTAC TTTTGACAACATTTATCTGCATGTCCAGATCAGCAATGAGTCGGCAATTGAC TTCTACAGGAAGTTTGGCTTTGAGATTATTGAGACAAAGAAGAACTACTAT AAGAGGATAGAGCCCGCAGATGCTCATGTGCTGCAGAAAAACCTCAAAGTT CCTTCTGGTCAGAATGCAGATGTGCAAAAGACAGACAACTGA SFXNl-> ACAGGCGCGCGCGAGGACGCGCTCCGGGGACGCGCGAGGACGCCGTGGCG SEQ ID CAMK4 GGAGAAGCGTTTCCGGTGGCGGCGGAGGCTGCACTGAGCGGGACCTGCGA NO: 62 GCAGCGCGGGCGGCAGCCCGGGGGAAGCGTATCTACATGAAAATGGGATT GTCCATCGTGATCTCAAACCAGAGAATCTTCTTTATGCAACTCCAGCCCCAG ATGCACCACTCAAAATCGCTGATTTTGGACTCTCTAAAATTGTGGAACATCA AGTGCTCATGAAGACAGTATGTGGAACCCCAGGGTACTGCGCACCTGAAAT TCTTAGAGGTTGTGCCTATGGACCTGAGGTGGACATGTGGTCTGTAGGAAT AATCACCTACATCTTACTTTGTGGATTTGAACCATTCTATGATGAAAGAGGC GATCAGTTCATGTTCAGGAGAATTCTGAATTGTGAATATTACTTTATCTCCC CCTGGTGGGATGAAGTATCTCTAAATGCCAAGGACTTGGTCAGAAAATTAA TTGTTTTGGATCCAAAGAAACGGCTGACTACATTTCAAGCTCTCCAGCATCC GTGGGTCACAGGTAAAGCAGCCAATTTTGTACACATGGATACCGCTCAAAA GAAGCTCCAAGAATTCAATGCCCGGCGTAAGCTTAAGGCAGCGGTGAAGG CTGTGGTGGCCTCTTCGCGCCTGGGAAGTGCCAGCAGCAGCCATGGCAGCA TCCAGGAGAGCCACAAGGCTAGCCGAGACCCTTCTCCAATCCAAGATGGCA ACGAGGACATGAAAGCTATTCCAGAAGGAGAGAAAATTCAAGGCGATGGG GCCCAAGCCGCAGTTAAGGGGGCACAGGCTGAGCTGATGAAGGTGCAAGC CTTAGAGAAAGTTAAAGGTGCAGATATAAATGCTGAAGAGGCCCCCAAAA TGGTGCCCAAGGCAGTGGAGGATGGGATAAAGGTGGCTGACCTGGAACTA GAGGAGGGCCTAGCAGAGGAGAAGCTGAAGACTGTGGAGGAGGCAGCAGC TCCCAGAGAAGGGCAAGGAAGCTCTGCTGTGGGTTTTGAAGTTCCACAGCA AGATGTGATCCTGCCAGAGTACTAAACAGCTTCCTTCAGATCTGGAAGCCA AACACCGGCATTTTATGTACTTTGTCCTTCAGCAAGAAAGGTGTGGAAGCA TGATATGTACTATAGTGATTCTGTTTTTGAGGTGCAAAAAACATACATATAT ACCAGTTGGTAATTCTAACTTCAATGCATGTGACTGCTTTATGAAAATAATA GTGTCTTCTATGGCATGTAATGGATACCTAATACCGATGAGTTAAATCTTGC AAGTTAACACAACGTAACACTTAAAAGCATACATTTTCAGCAACCAGTGGC ACATATTTGAAGTGAATAGTAGCAAATTGTTTTTGCTTTGAAAATCTAGCCA TCCTACATCCTTTGGATTTCTTCACAAGGCAGTAATTCCTTTGAACTACTGC TTAGCTAATACTAGGTAGTGCTAAAAGACATGTTCCCATAACTTTTACAACA TTTTACTTTTTATCATTGATGTGTTCAAACTGTTTACAAGGAGATGCTTATA GATGATAGTTGTACATATGTGCAAAAAAAAATCCACTTGCAATGGTAAGAA ATTGAAGTATCCTTAAAGGCCATGAAGCCATATGTCCCTAAA CREBl-> ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGT SEQ ID TMEM13 AACAGAAGCTGAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTG NO:63 1 CCACATTAGCCCAGGTATCTATGCCAGCAGCTCATGCAACATCATCTGCTCC CACCGTAACTCTAGTACAGCTGCCCAATGGGCAGACAGTTCAAGTCCATGG AGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCTCCACAAGTCCAAAC AGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCAGTGGA TAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTC CTACAGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAG GATTGAAGAAGAGAAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCA CTGTAACGGTGCCAACTCCAATTTACCAAACTAGCAGTGGACAGTATACAT TCGTTCAGTCAGAGAGCATAATAGAAGTACTGCGTTTTGATGATGGAGGGC TACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTA TATCTCTCTACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGC TGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACT TACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTAC AACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCTTCCAGGA GGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTA GAAAATACTTTATTTATTAATACATCTAATCATGGGGTATTTACTTACCAGG TATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGC CAGAGTCCCTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCT CACAGTGAGCCTTTACAGGTTGTAGAAATGTACTCTAGTGGAGGAGACCTT CACCTAGAACTCCCAACGGGTCAACAAGGAGGTACCAGAAAACTGTGGGA AATTCCTCCTTATGAAACCAAGGGAGTGATGAGAGCCAGTTTTTCATCTAG AGAAGCAGATAATCACACAGCCTTCATAAGAATAAAGACTAATGCTTCAGA CAGCACAGAGTTTATCATTCTTCCTGTTGAGGTTGAAGTTACAACAGCTCCT GGAATTTATTCCTCAACTGAAATGTTAGATTTTGGTACACTAAGAACACAA GATCTACCAAAAGTTTTAAACCTTCATTTATTAAATTCAGGAACAAAAGAT GTACCAATAACAAGTGTTCGACCTACACCACAAAATGATGCTATAACGGTA CACTTTAAACCAATTACATTAAAAGCATCAGAAAGTAAATACACCAAGGTT GCAAGCATTAGTTTTGATGCATCGAAGGCAAAAAAGCCATCTCAGTTTTCT GGGAAAATAACAGTTAAAGCAAAGGAAAAGAGTTATTCTAAACTTGAAAT ACCATATCAAGCAGAAGTTTTAGATGGTTATTTGGGATTTGATCATGCTGCA ACATTATTTCACATCCGAGACAGCCCTGCTGATCCTGTGGAAAGGCCAATTT ACCTTACTAACACTTTCAGTTTTGCGATCCTCATTCACGATGTGTTGCTACC AGAAGAAGCCAAAACAATGTTTAAAGTTCACAACTTCAGCAAACCAGTCTT AATTCTTCCTAATGAATCAGGATACATTTTTACCCTGCTTTTTATGCCTTCCA CATCATCCATGCACATTGATAACAACATTTTACTTATTACCAATGCTTCTAA ATTTCATTTACCCGTGCGGGTATACACAGGCTTTTTAGATTACTTTGTATTG CCCCCCAAAATAGAGGAACGTTTCATAGATTTTGGAGTACTGAGTGCTACA GAAGCAAGTAATATTTTATTTGCAATTATAAACAGCAATCCAATTGAGTTG GCTATAAAAAGTTGGCATATCATAGGAGACGGTTTATCAATAGAACTTGTA GCTGTGGAAAGAGGCAATAGAACTACAATAATTTCAAGCCTGCCAGAGTTT GAAAAATCCTCTTTATCAGATCAATCATCGGTAACATTAGCTTCAGGCTATT TTGCAGTCTTCAGAGTCAAACTTACTGCAAAAAAATTAGAGGGGATTCATG ATGGAGCCATCCAGATCACAACAGACTATGAGATCCTGACAATCCCTGTGA AGGCTGTGATTGCAGTAGGCTCACTGACCTGCTTCCCTAAGCACGTGGTTCT TCCACCTTCCTTTCCAGGGAAAATAGTTCATCAAAGTTTAAATATTATGAAT TCCTTCTCACAGAAGGTAAAAATACAGCAAATACGATCTTTGTCAGAAGAT GTGCGATTTTACTATAAACGATTACGGGGCAATAAGGAAGACTTGGAGCCA GGAAAAAAATCAAAGATTGCAAACATTTATTTTGATCCTGGACTACAGTGT GGGGATCATTGCTATGTTGGCTTGCCTTTTCTATCCAAATCTGAACCCAAAG TGCAGCCTGGTGTAGCCATGCAGGAAGATATGTGGGATGCTGACTGGGATT TGCATCAAAGCCTGTTCAAGGGATGGACAGGAATAAAGGAAAATTCAGGT CATAGATTGAGTGCTATATTTGAAGTAAATACAGACCTTCAAAAAAATATA ATATCAAAAATCACTGCTGAGCTCTCCTGGCCTTCCATACTTAGCTCACCCC GGCACTTGAAATTTCCACTTACTAATACAAACTGCTCCTCAGAAGAAGAGA TTACTTTAGAAAATCCTGCAGATGTTCCTGTCTATGTTCAGTTTATTCCTCTG GCTTTATATTCCAACCCTTCAGTGTTTGTAGATAAGTTAGTATCAAGGTTTA ACTTGAGTAAGGTGGCAAAGATAGATTTGAGAACACTAGAATTTCAAGTCT TCAGAAACAGTGCTCATCCACTGCAGAGTTCAACAGGATTTATGGAGGGCC TCTCTCGACATTTAATTTTAAACCTAATTTTAAAACCTGGAGAAAAGAAATC TGTCAAAGTAAAGTTTACTCCAGTTCACAACAGAACTGTTTCTTCACTTATC ATAGTCAGAAATAACCTGACTGTGATGGATGCTGTGATGGTCCAAGGACAA GGAACAACTGAGAACTTGAGGGTGGCAGGCAAGCTTCCAGGTCCAGGAAG CTCCTTACGCTTTAAAATCACGGAAGCATTGTTAAAAGATTGTACAGATAG TTTAAAACTAAGAGAACCAAATTTCACATTGAAAAGAACATTTAAGGTAGA GAATACAGGACAACTTCAAATTCACATAGAAACCATTGAAATCAGTGGATA CTCATGTGAAGGATATGGCTTTAAAGTTGTTAATTGTCAAGAGTTTACTCTA AGTGCCAATGCTTCTAGAGATATAATCATATTGTTTACTCCTGATTTTACAG CTTCTAGAGTTATTCGGGAACTGAAGTTTATAACAACCAGTGGCTCTGAGTT TGTATTTATATTGAATGCATCCCTTCCTTACCATATGTTAGCAACCTGTGCA GAAGCCCTACCCAGACCTAACTGGGAACTGGCTCTGTATATCATCATCTCA GGAATAATGAGTGCACTGTTTCTTTTGGTCATTGGAACAGCCTATTTGGAAG CTCAAGGAATATGGGAGCCATTTCGAAGGCGGCTATCCTTTGAGGCCTCGA ACCCGCCCTTCGATGTGGGAAGGCCATTTGATCTCAGGAGAATCGTTGGTA TTTCATCTGAAGGAAACTTGAACACACTCAGCTGTGACCCCGGTCACAGTA GGGGGTTCTGTGGAGCAGGCGGTTCATCATCCCGACCCAGTGCCGGGAGTC ATAAGCAGTGTGGCCCATCGGTCCACCCACACAGCAGTCACAGCAATAGAA ACTCAGCTGACGTGGAAAACGTCAGAGCCAAAAACAGTTCAAGTACCTCTA GTAGGACTTCTGCTCAAGCAGCTTCTTCACAGTCTGCTAACAAAACAAGCC CCCTTGTCTTAGATTCGAACACAGTGACTCAAGGTCATACAGCGGGCAGAA AGTCCAAAGGGGCAAAGCAGAGCCAGCACGGCAGCCAGCACCATGCCCAC AGCCCGCTGGAGCAGCACCCTCAGCCTCCTCTGCCACCGCCAGTGCCTCAG CCCCAGGAGCCGCAGCCTGAAAGGCTGTCTCCCGCCCCCCTCGCACACCCT TCCCACCCAGAACGTGCCAGCAGCGCGAGGCACAGTTCCGAGGACTCGGA CATCACCAGTCTCATAGAAGCCATGGACAAAGACTTCGACCACCATGACTC CCCAGCCCTAGAAGTGTTTACAGAGCAGCCTCCATCGCCATTGCCAAAAAG CAAAGGGAAAGGAAAACCTCTTCAGCGCAAGGTGAAACCACCTAAGAAGC AAGAGGAAAAGGAGAAGAAGGGAAAGGGAAAGCCACAGGAAGATGAGCT GAAGGACTCTTTGGCTGATGATGATAGCTCCTCCACCACCACAGAGACCTC CAACCCTGACACAGAACCGCTCCTCAAGGAGGATACAGAAAAGCAAAAGG GAAAACAAGCCATGCCTGAAAAACATGAAAGTGAAATGTCTCAAGTGAAG CAAAAAAGCAAAAAACTCTTAAATATTAAGAAAGAAATCCCAACAGATGT GAAACCCAGTTCATTAGAACTACCATATACTCCCCCTTTGGAAAGTAAGCA ACGTAGAAATCTCCCAAGCAAGATTCCTCTTCCAACTGCAATGACAAGTGG ATCCAAATCACGAAATGCCCAGAAAACAAAAGGTACAAGTAAGTTAGTGG ATAACAGACCACCTGCCCTAGCAAAATTCCTCCCGAATAGTCAAGAATTAG GCAACACCAGTAGCTCAGAGGGTGAAAAAGACTCTCCTCCACCGGAGTGG GATTCCGTTCCAGTTCACAAACCTGGCAGCTCTACTGATAGTCTTTATAAAC TTTCTCTGCAAACCCTCAACGCAGACATTTTCTTAAAACAACGCCAGACCTC ACCGACACCTGCTTCCCCGTCTCCCCCAGCTGCCCCCTGCCCCTTTGTGGCC CGGGGCAGCTACAGCAGCATCGTCAACAGCAGCTCCAGCAGTGACCCTAAA ATAAAACAGCCAAATGGAAGCAAACACAAGTTGACAAAGGCAGCCTCGCT CCCGGGCAAGAACGGCAACCCCACTTTTGCTGCAGTCACGGCTGGCTACGA CAAGAGCCCAGGTGGGAATGGCTTTGCTAAAGTTTCTTCAAACAAAACAGG TTTCTCCAGCAGCCTTGGCATTTCACACGCTCCTGTTGACAGCGATGGCTCA GACAGCTCGGGTTTGTGGAGTCCCGTCAGCAACCCAAGCAGCCCTGACTTC ACTCCCCTCAATTCGTTCTCCGCCTTTGGAAACTCTTTTAATCTAACTGGTG AAGTTTTCAGCAAACTCGGATTATCTCGATCGTGCAATCAGGCCTCACAGA GGAGCTGGAACGAGTTTAATAGTGGCCCTTCATACCTTTGGGAGTCGCCAG CGACAGATCCCAGTCCTTCCTGGCCAGCCAGTTCCGGCTCCCCGACCCACA CAGCCACATCGGTCCTCGGTAACACCAGCGGCCTGTGGTCCACCACTCCAT TCAGCAGCTCCATTTGGTCCAGCAACCTTAGCAGCGCCCTTCCCTTCACCAC TCCAGCAAACACGCTGGCAAGCATCGGCCTCATGGGCACAGAAAACTCCCC TGCTCCTCACGCTCCCTCCACCTCCAGTCCAGCTGACGACTTGGGACAGACC TACAACCCGTGGCGGATATGGAGCCCCACGATTGGAAGAAGAAGCTCGGA CCCTTGGTCTAATTCGCACTTTCCTCACGAGAATTAA ESRl-> ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAG SEQ ID C6orf21 1 ATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCC NO: 64 CTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTG TACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCC AACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAG GCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGC GTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCA GCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGTCCACCAA TCGATTACTTTGATGTATTTAAAGAATCAAAAGAGCAAAATTTCTATGGGTC ACAGGAATCCATCATTGCTTTATGTACTCACCTGCAACAATTGATAAGAACT ATTGAAGACCTAGATGAAAATCAGCTGAAAGATGAGTTTTTTAAACTTCTG CAGATTTCACTGTGGGGAAATAAGTGTGATCTGTCTCTCTCAGGTGGAGAA AGTAGTTCTCAGAATACCAATGTACTAAATTCATTGGAAGACCTAAAACCT TTCATTTTATTGAATGATATGGAACATCTTTGGTCATTGCTTAGCAATTGCA AGAAAACAAGAGAAAAAGCTTCTGCTACTAGAGTGTATATTGTTCTCGATA ATTCTGGATTTGAGCTTGTTACAGATTTAATATTAGCCGACTTCTTGTTGTCC TCTGAACTGGCTACTGAGGTTCATTTTTATGGAAAAACAATTCCATGGTTTG TTTCTGATACTACTATACATGATTTTAATTGGTTAATTGAACAGGTAAAACA CAGTAATCATAAGTGGATGTCCAAGTGTGGGGCTGACTGGGAAGAGTATAT TAAAATGGGTAAATGGGTTTACCACAATCATATATTTTGGACTCTGCCTCAT GAGTACTGTGCAATGCCTCAGGTTGCACCTGACTTATATGCTGAACTACAG AAGGCACATTTAATTTTATTCAAGGGTGATTTGAATTACAGGAAGTTGACA GGTGACAGAAAATGGGAGTTTTCTGTTCCATTTCATCAGGCTCTGAATGGCT TCCATCCTGCACCACTCTGTACCATAAGAACATTAAAAGCTGAAATTCAGG TTGGTCTGCAGCCTGGGCAAGGGGAACAGCTCCTGGCCTCTGAGCCCAGCT GGTGGACCACTGGAAAATATGGAATATTTCAGTACGATGGTCCCCTTTGA UTP23-> ATGAAGATCACAAGGCAGAAACATGCCAAGAAGCATCTTGGCTTCTTCCGC SEQ ID AD21 AACAACTTCGGAGTCCGCGAGCCGTACCAGATCCTGCTGGACGGCACCTTC NO: 65 TGTCAGGCGGCGCTGCGGGGCCGCATCCAGCTGCGGGAGCAGCTGCCCCGC TACCTCATGGGGGAGACGCAGCTGTGCACCACAAGATGTTCTACGCACATT TTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCGGCCCATT GGGATAAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCA GCGTGGAGAGTATCATCTCACCAAAGGTGAAAATGGCATTACGGACATCAG GACATCTCTTACTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACC TTCTTGCAGACTGTAATGAAGCATTCATTAAGATAAAGATGGCTTTTCGGCC AGGTGTGGTTGACCTGCCTGAGGAAAATCGGGAAGCAGCTTATAATGCCAT TACTTTACCTGAAGAATTTCATGACTTTGATCAGCCACTGCCTGACTTAGAT GACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTGGAAGAG ATAACCATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGAT TTTGGTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCT TTTGAGGATGACGACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAG AGTCTGAACAGAGCACCAGCAATCTGAATGAGAAAATTAACCATTTAGAAT ATGAAGATCAATATAAGGATGATAATTTTGGAGAAGGAAATGATGGTGGA ATATTAGATGACAAACTTATTAGTAATAATGATGGCGGTATCTTTGATGATC CCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCACATG ACGATATGGATGAGGATGATAATGTATCAATGGGTGGGCCTGATAGTCCTG ATTCAGTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACAC TTGTTCCAAATGAGGAAGAAGCATTTGCATTGGAGCCTATTGATATAACTG TTAAAGAAACAAAAGCCAAGAGGAAGAGGAAGCTAATTGTTGACAGTGTC AAAGAGTTGGATAGCAAGACAATTAGAGCCCAACTTAGTGATTATTCAGAT ATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTGATGATGTGG AAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTG TGGAATAACAGACTACTGAAGCTCTTTACACGCTGTCTTACACCGCTTGTAC CAGAAGACCTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGAT GAATTCCTCAAAGAATTTGAAAATCCAGAGGTTCCTAGAGAGGACCAGCAA CAGCAGCATCAGCAGCGTGATGTTATCGATGAGCCCATTATTGAAGAGCCA AGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGAACAAACATAGATGA GTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCTGGACA AATTGACCCAGAGCCTGTGATGCCTCCTCAGCAGGTAGAGCAGATGGAAAT ACCACCTGTAGAGCTTCCCCCAGAAGAACCTCCAAATATCTGTCAGCTAAT ACCAGAGTTAGAACTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAA AAGAAGATGATGAAGAGGAAGAGGATGAAGATGCATCAGGGGGCGATCAA GATCAGGAAGAAAGAAGATGGAACAAAAGGACTCAGCAGATGCTTCATGG TCTTCAGCGTGCTCTTGCTAAAACTGGAGCTGAATCTATCAGTTTGCTTGAG TTATGTCGAAATACGAACAGAAAACAAGCTGCCGCAAAGTTCTACAGCTTC TTGGTTCTTAAAAAGCAGCAAGCTATTGAGCTGACACAGGAAGAACCGTAC AGTGACATCATCGCAACACCTGGACCAAGGTTCCATATTATATAA KLHDC4- ATGGGCAAGAAGGGCAAGAAGGAGAAGAAGGGCCGCGGCGCGGAGAAGA SEQ ID > CGGCCGCCAAGATGGAGAAGAAGGTGTCTAAGCGCTCGCGGAAGGAGGAG NO:66 LRPAP1 GAAGACCTGGAAGCGCTCATAGCCCATTTCCAGACACTCGATGCCAAGAGG ACTCAGACTGTGGAACTTCCGTGCCCCCCACCCTCACCAAGGTTAAATGCCT CCCTCTCGGTTCATCCTGAGAAAGATGAGTTAATCCTTTTTGGAGGTGAATA TTTCAACGGCCAAAAAACTTTTTTGTATAACGAGCTCTATGTCTACAATACC AGAAAGGACACCTGGACCAAAGTTGACATCCCCAGTCCACCTCCGAGGCGC TGTGCTCACCAGGCGGTGGTAGTGCCTCAAGGTGGCGGACAGCTGTGGGTC TTTGGAGGGGAGTTTGCCTCTCCCAACGGAGAGCAGTTCTACCACTACAAG GATCTCTGGGTCCTGCATTTGGCCACCAAGACCTGGGAACAAGTCAAATCA ACAGGCGGTCCTTCGGGTCGGAGTGGACATCGGATGGTGGCCTGGAAGAG ACAATTGATCCTGTTTGGTGGCTTCCATGAAAGTACACGGGATTACATCTAC TACAACGACGTGTATGCCTTTAATCTGGACACCTTCACATGGAGCAAGCTG TCCCCGTCAGGGACGGGGCCCACACCCAGATCAGGCTGCCAGATGTCCGTC ACTCCCCAGGGCGGCATCGTCGTCTATGGGGGCTACTCGAAACAGCTGCAT CTTCCTCCCGTGAGGCTGGCCGAGCTCCACGCTGATCTGAAGATACAGGAG AGGGACGAACTCGCCTGGAAGAAACTAAAGCTTGACGGCTTGGACGAAGA TGGGGAGAAGGAAGCGAGACTCATACGCAACCTCAATGTCATCTTGGCCAA GTATGGTCTGGACGGAAAGAAGGACGCTCGGCAGGTGACCAGCAACTCCCT CAGTGGCACCCAGGAAGACGGGCTGGATGACCCCAGGCTGGAAAAGCTGT GGCACAAGGCGAAGACCTCTGGGAAATTCTCCGGCGAAGAACTGGACAAG CTCTGGCGGGAGTTCCTGCATCACAAAGAGAAAGTTCACGAGTACAACGTC CTGCTGGAGACCCTGAGCAGGACCGAAGAAATCCACGAGAACGTCATTAG CCCCTCGGACCTGAGCGACATCAAGGGCAGCGTCCTGCACAGCAGGCACAC GGAGCTGAAGGAGAAGCTGCGCAGCATCAACCAGGGCCTGGACCGCCTGC GCAGGGTCAGCCACCAGGGCTACAGCACTGAGGCTGAGTTCGAGGAGCCC AGGGTGATTGACCTGTGGGACCTGGCGCAGTCCGCCAACCTCACGGACAAG GAGCTGGAGGCGTTCCGGGAGGAGCTCAAGCACTTCGAAGCCAAAATCGA GAAGCACAACCACTACCAGAAGCAGCTGGAGATTGCGCACGAGAAGCTGA GGCACGCAGAGAGCGTGGGCGACGGCGAGCGTGTGAGCCGCAGCCGCGAG AAGCACGCCCTGCTGGAGGGGCGGACCAAGGAGCTGGGCTACACGGTGAA GAAGCATCTGCAGGACCTGTCCGGCAGGATCTCCAGAGCTCGGCACAACGA ACTCTGA LOC7298 ACCTGAGACTACCTTTCTGCGATCACAGGATTCCCGGCGGTGACTTGACCCC SEQ ID 52-> GGAAGTGGGGTGTGAAGCTCCGGTGCTGGTGCGGCGGGGGACTGCGGGGC NO: 67 GLCCIl CAGCCTCAGGTAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGC AGCAGCAGCAGCAGCAGCAGCAATGTTTCACTTCTTCAGAAAGCCTCCGGA ATCTAAAAAGCCCTCAGTACCAGAGACAGAAGCAGATGGATTCGTCCTTTT AGGAGATACAACAGATGAGCAAAGAATGACAGCAAGAGGCAAAACTTCGG ACATAGAGGCCAACCAACCTTTGGAGCGGACAAGGCAAAATCTCAGCAAG TTCGGACCTCTAGTACAATAAGGCGAACCTCCTCTTTGGATACAATAACAG GACCTTACCTCACAGGACAGTGGCCACGGGATCCTCATGTTCACTACCCTTC ATGCATGAAAGACAAAGCTACTCAGACACCTAGCTGTTGGGCAGAAGAGG GTGCAGAAAAGAGGTCACATCAGCGTTCTGCGTCATGGGGGAGTGCTGATC AACTAAAAGAGCAGATCGCCAAACTGAGGCAGCAACTACAACGCAGTAAA CAGAGTAGTCGTCACAGTAAGGAGAAAGATCGCCAGTCACCTCTTCATGGC AACCATATAACAATCAGTCACACTCAGGCTACTGGATCAAGGTCAGTTCCT ATGCCACTGTCAAATATATCAGTGCCAAAATCATCTGTTTCGCGTGTGCCCT GCAATGTAGAAGGAATAAGTCCTGAATTAGAAAAGGTATTCATTAAAGAA AATAATGGGAAGGAAGAAGTATCCAAGCCGTTGGACATACCAGATGGTCG AAGAGCTCCACTTCCTGCTCATTACCGGAGCAGTAGTACTCGCAGCATTGA CACTCAGACTCCTTCTGTCCAGGAGCGCAGCAGTAGCTGCAGCAGTCATTC ACCCTGTGTCTCCCCTTTTTGTCCCCCGGAATCCCAGGATGGTAGCCCTTGC TCAACAGAAGATTTGCTCTATGATCGTGATAAAGACAGTGGGAGTAGCTCA CCGTTACCCAAGTATGCTTCATCTCCCAAACCAAACAACAGCTACATGTTCA AACGGGAGCCCCCAGAGGGATGTGAGCGAGTGAAGGTCTTTGAGGAAATG GCGTCTCGTCAGCCTATCTCGGCCCCTCTCTTTTCATGTCCTGACAAAAACA AGGTTAATTTCATCCCAACCGGATCAGCTTTCTGTCCTGTAAAACTTCTAGG CCCCCTCTTACCTGCTTCTGACCTTATGCTCAAGAACTCCCCTAACTCTGGC CAGAGCTCAGCTTTGGCAACTCTGACCGTTGAGCAGCTCTCATCCCGGGTTT CCTTTACGTCTCTTTCTGATGACACCAGCACAGCGGGCTCCATGGAGGCCTC TGTCCAGCAGCCATCCCAGCAGCAGCAGCTCCTGCAGGAACTGCAGGGTGA GGACCACATCTCTGCTCAGAACTATGTGATCATCTAAAAAAGGGGGAGCTG GCCTCCACCCTATGTTCCATGGATTCGGAACAAGATTTCAGACATCTGCATG AGTGACAAACTTTCTGAACACCACCACCACCAATAATACTTATCAGCATCA TAAAGTATCTCTTAAACACTGATCTTGGCAGGGACGGAACTCCTATTCAGC AGTTTTTGTGGAAAGCAGTAATGCTTGCAAAACGTGTGTGTCATTCAGCATT TTAAGTGGAGACTATGCATTTCATAGTATATTTGACAGATTAGTACTGTGTC CTGTGTTTTGTTCCAGATTCTTCAGTATAAATAAGCTCTATATCAAAAAGTT GCCTGTCTAAATAGAAAATGTCTTGCTGTGTTTTGTCCTATGGAAAATACTG TAATTCAGGATTATGTTTACAATTGATCCAGGTGTTTGTTTCTAACTTCTGTA ATACATACAATGCAAAAAAAAAAAAAAAAAAATGGCCACAACAGTTGCAC AGTGCCCACCCTATGGCCTAGCTTCAGGTACTTCAGTTGAAGTCTAAACTCA GGTAACTTGGAATGTATATCATATTGGGATATTAAATATTTCACAGCTAAA AAGCTAAAGAGGGAACATCACTCTTTTGCCTTTCCTTATTTTATGCATTTCC CTTTCCTCATTACATTCCACATTCTTAGAATAAGAAGTGCATTCAATCCTAG GAGAATGATAATCCTGGACATGGGTGAACATGAGGAGAACCAGCAAAATC TGTGGTGTTTGACATCACTTTGTCATGTGGTTACAAGTAAAACAACTGTTGC ATTCACTGTTTCAACATGTGTACATGTGGCTTTTTTAAAAGTTCAGGTGTTG CTCAGTAAAGGACTGTGACAATGTTGCAAATAAAGTGTTCAGTACTGGACT GTACATAAACATTCCACATTGTGTGTGATGAAATTTAAAGACAAGAATGTC TAGAGTTAATTTCAAAATAAGTGAAGTGTTTGACGGAATGGTTGAGATTTTT TTGTTTATGTTAGCCATCAGGGTCATAACTGTTACCATTTTATCTAAAGACA TATTTATATTTAGTTTCTCCCTTGGAAATTCTTTATTTTGCAGGTGAAAAAGT GACATACTTTTTGTTATTGTCTTCCTCAAGCAGTTTAGGTGCATGATCTTCAT TTACATAGAATACTTGGGTCTCAGAATTGATGCAACATAAGCAGGTTTTTTT GGTGACTTACAAGAGCAATAGTTTGAAGCTATCTCATTTAAGCCTCTCATAA TGCATAATCATGAGTAGTTTTGAAATTTGCAACCTGTGAGGTAGAGCATAA ACTCAAGAAAATAGCCTTGAACTTGCAGACTTTTGACACAAGTTCTCCACA AAGTGTGAAGAGAGCCCCAGGCATTCCTGATTGGTCAATGGGAGAGCCTAA CTTTCATTGTTTTCTTCAGTACAAAGAGTATCCAAAAGCTAAGTTTTTGTAT TCCACTACTTTCAGTTCAATAAAACCTAGAGTTGTTTCATCTGCGCCTAAAG TGTATGGCACAATTTTCTTAAGAATTAGGGGAACCAGGTGCCTACAGTTAA AGGAACGTTTCAGTTCCTTTCATTCATTCCTGGGTTTTTCTTTTATTTTCTAA GAAGGTTGAAGAAGGATGAGTGATAGAGAAGAAAGCAACACCATTGATTT TTTTTTTTAAGAAATGATATATATATGTATATGTTTGTGTGTGTGTGTGTGTG TGTGTGTGTGTGTATTCTGTGCATTATTTTGTCATGATCTCAATTCTCTTCTT TCCACCAAAGTTTGTCGTAATATTTTCTCCTGAAGGTGCATTCTGGCTCCTTT AAATTAGTCAGTGTTATATTGTAGGAGACTGTCATGGAAAAAAGGACTCAG TTTACTTTCGTCATTTTCACAGGGGAACCTTTTAAAACAATCTTTTCAGCAG CAGATACCTTTAACCCTAATAATCTCAGGCCTTGATGAAAATACTATATTTT GTAGATTATGGTTAAAGGGGGAAAATTACTAGTTCCGTAAGATAAATATGA GCTCCATTTGACTTCTGATGTCTGGTTTAGCATTACATAATATGTTGATCTTA CACTCTGCTTTTGTCCAAATAAAATGCAATAGTATCAATATCAATTTCAGAA AAATGGACTGAATATGCTTTTTTGGTGATGAAATCTCATGTACGATATTTAT AGTGATGTGCTTTTATTTTCTCATGAGATACTAAATATTAATTGTGTTGTAC ATTTGTTCTTAGCATATATTAAAGTTTTGAACCAAATGTGTTAAAGCTTACG CTTTGCCATGTAAATTTCCCAGAAGTTGTTGAGCTCAAATGTATCCTACATC CAGCTGTAGAAATTTGTCAGAAATTGTTTAAATTTTGTATATAATTGTACTG TTTAATTCTAGCCATTGCGCTGAACAGTATTTGAGTTACCATATAATATGGC TTTACACAAGGAAATGTGTGGCTTTTGTTTTGTATTTTTTCAGTATAGAAGT TCCTGTGTCTTATTTAAATAAAGTTATTAGTAAAACTGAAA ARNT2-> ATGGCAACCCCGGCGGCGGTCAACCCTCCGGAAATGGCTTCAGACATACCT SEQ ID MESDC2 GGATCTGTGACGTTGCCCGTTGCCCCCATGGCGGCCACCGGACAGGTGAGG NO:68 ATGGCGGGGGCCATGCCTGCCCGTGGAGGAAAGCGGCGTTCCGGAATGGA CTTCGATGATGAAGATGGTGAAGGCCCCAGTAAATTTTCAAGAAAGATGAT GACATTGAAGAAGGAGATCTTCCAGAGCACAAGAGACCTTCAGCACCTGTC GACTTCTCAAAGATAGACCCAAGCAAGCCTGAAAGCATATTGAAAATGACG AAAAAAGGGAAGACTCTCATGATGTTTGTCACTGTATCAGGAAGCCCTACT GAGAAGGAGACAGAGGAAATTACGAGCCTCTGGCAGGGCAGCCTTTTCAA TGCCAACTATGACGTCCAGAGGTTCATTGTGGGATCAGACCGTGCTATCTTC ATGCTTCGCGATGGGAGCTACGCCTGGGAGATCAAGGACTTTTTGGTCGGT CAAGACAGGTGTGCTGATGTAACTCTGGAGGGCCAGGTGTACCCCGGCAAA GGAGGAGGAAGCAAAGAGAAAAATAAAACAAAGCAAGACAAGGGCAAAA AAAAGAAGGAAGGAGATCTGAAATCTCGGTCTTCCAAGGAAGAAAATCGA GCTGGGAATAAAAGAGAAGACCTGTGA ΝΑΤ 1-> ACTTCCTCATAGACCTTGGATGTGGGAGGATTGCATTCAGTCTAGTTCCTGG SEQ ID DDHD2 TTGCCGGCTGAAATAACCTGTTAATGATTTTCGCAGTGTTTCCTTGAACTTG NO: 69 CTACAGACACATTTTAAGAAAGCCCAAGAAAATCAGCAGATTGGGAGGGT AGAATTTCTTCCAGTCAACTGGCACAGTCCTTTGCATTCTACTGGTGTGGAT GTAGATCTGCAGCGAATAACCCTGCCCAGCATTAACCGCCTCAGGCACTTC ACCAATGACACAATTCTGGATGTCTTCTTCTACAATAGTCCCACCTACTGTC AGACTATTGTGGACACAGTTGCTTCTGAAATGAACCGAATATACACACTTTT TCTACAGAGGAACCCTGATTTCAAAGGGGGTGTATCCATTGCTGGTCATAG TTTAGGTTCGCTTATATTGTTTGATATCCTAACAAATCAGAAAGATTCTTTG GGGGATATTGACAGTGAAAAGGATTCGCTAAATATTGTAATGGATCAAGGA GATACACCTACACTAGAGGAAGATTTGAAGAAACTTCAGCTCTCTGAATTC TTTGATATCTTTGAGAAGGAGAAAGTAGATAAGGAAGCTCTGGCTTTATGT ACAGACCGAGATCTTCAGGAAATAGGAATTCCTTTAGGACCAAGAAAGAA GATATTAAACTATTTCAGCACCAGAAAAAACTCAATGGGTATTAAGAGACC AGCCCCGCAGCCTGCTTCAGGGGCAAACATCCCCAAAGAATCTGAGTTCTG CAGTAGCAGTAATACTAGAAATGGTGACTATCTGGATGTTGGCATTGGGCA GGTGTCTGTGAAATACCCCCGGCTCATCTATAAACCAGAGATATTCTTTGCC TTTGGATCTCCCATTGGAATGTTCCTTACTGTCCGAGGACTAAAAAGAATTG ATCCCAACTACAGATTTCCAACGTGCAAAGGTTTCTTCAATATTTATCACCC TTTTGATCCTGTGGCCTATAGGATTGAACCAATGGTGGTCCCAGGAGTGGA ATTTGAGCCAATGCTGATCCCACATCATAAAGGCAGGAAGCGGATGCACTT AGAACTGAGAGAGGGCTTGACCAGGATGAGTATGGACCTTAAGAACAACT TGCTAGGTTCGCTGCGGATGGCCTGGAAGTCTTTTACCAGAGCTCCATACCC TGCCTTACAAGCTTCAGAAACACCAGAAGAAACTGAAGCAGAACCTGAATC AACTTCAGAGAAGCCTAGTGATGTTAACACAGAAGAGACCTCTGTGGCAGT TAAAGAAGAAGTCCTGCCTATCAATGTGGGGATGCTGAATGGAGGCCAACG CATTGACTATGTGCTACAGGAGAAGCCTATTGAAAGTTTTAATGAGTATTTA TTTGCTTTACAAAGCCATCTATGCTACTGGGAGTCTGAAGATACAGTATTGC TCGTCCTCAAAGAGATCTACCAAACCCAGGGTATCTTCCTTGATCAGCCTTT ACAGTAAAAATGACCCATCTATGGCTGCTTAATACGGACATTGAGGGATCC TTCCCCAGAAAATCCACCTGTTTGTTGCTGCAATTTTCCTCTCCTCAGCTGC GTCATTTCCTGCATGTTGCCTGCCACTTACTCACCACTGGGGTCTTTGGAAG ATAATCTTCCTCTTTGGAAATGAATGGAAAAGCAAAAGGCCCTATTACTTTT AACCACTGGCTTCATATAAACACTTGCCATTTTTTTCTGCATAGCTGGGGGT GGTTTGTGTCTTTAATTCTTTGATGATAGTTTATAGTTGCCACACTTTATTGA TTAGTACTTGACAGGGTGTAAAGCCTATTTTGGGTTTGATTTGTTTTGGGTG GGGTAGACATGTTTTTAAGGAACTTATTGCTTATCTTTAGAAAATGTTCTAG TTTGGAAACAGATTCTTGAGATTCAGAAGGCATTTTGGAGTACACTTATCTC TTGTTTGTGTTGAACTGAAGGCTAAGTCTCAGTGGACATGGAAAAGACTTTT GGGTGATTTATTTTTGAACCTGCATTTCTTTCTTATGTGTAGTGTATGAAGA AAGACTAGAATGTAGCTTTAAAAAAGTGTTGTTTACTCTCTTAGAACTGAC AGACTTATTGCCAGAAATCACTGATGTTCATTGTTTTTGCAACTGTTTGAGC TGCTGTAAGAGTCTAAAGTTGACAAGTTAGTTCATGTTAGGTGCATCTTTAT AAAGCAAAGATGTTGTATATCCTAGGCCTCCCTTTTATATTTGATAGAAGTT ATTTGCTAATAGCTTCTATTCTTACGTTGAAAATAGTTGTAAAAGCTGATGA ACCTGAAATTGTGTAGCCTCTACAGGCTGCTGAGGTTCTAAATAAAACCTTT TAGTGGTGCCTTTATGGTGAAACAGAATTTGTCACCTGCCATTTCTACTTGA GCTAAGGTAGTATTGTGTATCCTCTTTCCTTCTTAGGTATCCATAATCCACA AAGCATATTTAAAAGGCTCTTGGCACGGGCAGCATTGGTTGAGCAGGTAGG TTTGGCTAGGGGGAAATGTTTAACTTGTTCTGAAAGAAAAACTTATGTCTGT AGGGTCCAAGAAACAGCTATTCCAGAGTCAGTGTCAGCTGAGTCTGGAACA TATGAAGTGAGGTTTACTTCTAAGAACACAAGTGACTGCACACTAATTTTGT CAAGGCATCTTTTCACTACTTTGCTGTAGATTTTTCTTCTTCATTGGTCAGTT TGTCATTGTCTTTGTAGTTCTCTTTATGATAATCCTTTATACTTGCTCTCAGA TTCCACAGGCCTCTGTTTATAGAGTGGCAAAGGCAGGCGAGCTGTGGTTTA TTGTTTATAAATTTTTTTATAAATGTTATGGTATTCAAAGCCACTGACATTTA ATATTTACTGAAGCCATTCCTTAGACAGCAGTGGTCTTTATCCCTTTCTGGA AAGAAAAGGAAAATGAAGGGTAATTACTGTCACCATGGAGATTGTAGAGG TAAGGTTGGGGTATAGGTCAGGCCTGGCCTTTCTTTGTCATCTGCTTATAGT CTAGTGCTAAGTATGCCACTAAGTTTCAGATATATGGAATACTTTATTTTTT TAAAGGTATATAAACTCTGAGTTATTGAGAATTAAGTATTCACTGTATATTA AGGGGAAGCTTTTGCCAAGTTGTGGTCTTCAAATTTATGTTTACTCTTCCTA TTGGCAGAATAGGTGCTATTTAAGAGTAAACCAAAGGATAAGCAGAGGGA GTCCCTATAACCAAAGATGGACAGCATAGCCCTGGATAGCCAGATAAACCA CTCTTTGTATTAAGAAATGTTTCTTTCCTAGTGGTGAGGGGTGGGTAACTGT GAAAGAGCTTTATATCTTGTCTATTCATGGTATTATAGCTGTATATTCCCAG GATGATAAGCTTGATTGAAATCCTGTATTTAGTCATATATTATTTGCGCTGC TTCATTTGTATCATGTGCAATCTCTAGACCAACCCTATTTTTAAACTCTGGT ACAGCATCATTTTGTACATATTCCCAGCTGCAGAACTAGTATCACTTATCTC AGCAAAAGAGATTGTTTGCATGGAAAGATTAATAGCACTGATTAGATTTCT AATATTTTGCATTTTTGAAATGTTTGTTTTCTACGTGATTATATTTAAAACTT TAGTAAATACTAACATGAAACCATAT ZBTB34- CGGGGACTGGCCTGGCGCCGGCGGCGGCGGAGGGGGCGCCGCGGGCGGGC SEQ ID > GATGTGAGCGCGGCGCTCTGGACAGGACTGAATTTGCTCTTAAAGAAATCA NO:70 SCAI TGTCCTCTGGAGGTGCTGAAGATGATATCCCACAGGGAGAGAGGAAAACA GTTACAGATTTTTGTTATCTTCTGGATAAATCTAAGCAACTGTTCAATGGGT TAAGAGATTTGCCACAATATGGACAGAAGCAGTGGCAGTCCTATTTTGGAA GAACTTTTGATGTTTACACCAAACTCTGGAAGTTCCAGCAGCAGCATCGAC AAGTCTTGGATAATCGGTATGGCTTGAAGCGCTGGCAAATAGGAGAAATTG CTTCCAAGATTGGGCAGCTATACTATCATTATTACTTACGCACATCGGAAAC CAGCTATCTGAATGAGGCTTTTTCCTTCTATTCTGCAATCAGACAGAGATCA TATTATTCTCAAGTCAATAAAGAGGACAGACCTGAATTGGTAGTTAAGAAG TTACGATATTATGCAAGATTTATAGTAGTTTGTCTTCTTCTCAACAAAATGG ATGTTGTAAAGGATCTGGTAAAGGAATTGTCAGATGAAATTGAAGATTATA CTCACCGATTTAATACTGAAGATCAAGTGGAATGGAACTTGGTGCTTCAAG AAGTAGCAGCTTTCATTGAGGCGGATCCTGTAATGGTATTAAATGATGATA ATACCATTGTTATCACATCGAATCGCCTTGCTGAAACAGGAGCCCCATTGCT GGAACAGGGCATGATTGTGGGACAGTTGTCTCTGGCTGACGCACTCATTAT TGGTAATTGTAATAATCAGGTTAAGTTCAGTGAACTAACTGTTGACATGTTC CGGATGTTACAAGCTCTGGAAAGGGAGCCAATGAATTTAGCTTCCCAGATG AATAAACCAGGAATGCAGGAATCAGCTGACAAGCCTACTAGACGAGAAAA CCCCCACAAGTATCTGCTCTACAAACCAACCTTCAGCCAGCTATATACCTTC TTAGCAGCGTCTTTTAAGGAGCTGCCTGCCAATAGCGTGCTTCTGATTTACC TGTCGGCCACTGGCGTTTTCCCCACAGGTCGTTCTGATAGTGAAGGTCCTTA TGATTTTGGAGGTGTACTTACTAATAGTAACCGGGATATTATTAATGGAGAT GCCATCCACAAACGAAATCAGTCCCACAAGGAAATGCACTGCCTTCATCCC GGGGATCTCTATCCTTTCACCAGGAAGCCACTGTTCATCATTGTGGATTCGT CTAATAGTGTTGCGTATAAGAATTTCACAAACTTGTTTGGACAGCCACTAGT CTGCTTGCTTTCTCCTACAGCATATCCAAAAGCTTTACAAGATCAATCTCAG CGAGGTAGCCTCTTCACTCTCTTTTTGAACAATCCTCTAATGGCCTTCCTATT TGTCTCTGGATTGTCAAGCATGCGCAGAGGCCTATGGGAAAAGTGTCAAGA ATATCTTCGAAAAATCAACCGTGATATTGCCCAGCTACTGACTCATTCACGT TCAATAGATCAGGCATTTCTCCAGTTTTTTGGAGATGAATTTCTTCGCTTGC TCCTCACAAGATTTATCTTTTGTTCAGCCACCATGAGGATGCACAAGATTTT TCGGGAAACACGAAATTATCCAGAATCATATCCACAACTGCCAAGGGATGA AACAGTGGAGAATCCTCATCTCCAGAAGCACATTTTGGAATTAGCATCCAT TCTGGATGTTCGAAACGTGTTCTTTGAGAATACCATTGATGACTATTAAAAC AAAAACCCTGTTGTCGAAACAAGTTTTCATTTTCCACAAATTTTAAATGGTG CAGTTTTCTAACGTGATAAGACACATAGTGGTGTTACTTAGTTTTTATTTTTT AATTTAGGGCCACCATTTTAAAAACAAACAAAAAAATGTTCACACTTTTAG GGTAACTGTTTTAAAATGCAACCTTTCAGGTCTTTTAAAATCTTAACCTTGG AATTTTTATTTTTTGATTTTGAGGGATGGATATTTACCTCCAACTTCTAATCC TACACTCAAATAGTCACTATTCTCACCCTGAGAAGAGTAAATCATTTATTTT TGTATAATGAGGTAAATCCAACTCTTATACTTGGACCTAAGTTAAATGTCTG GATTTGGAAATATGTAATGGTTCATAATGATGAAGCTAGCCACCATGGACT ACTGAAAATCAAGAACAGAGTCCCTCCATAATATATTTTTTCTCATTCCAAC TTAGCTGGTAGAAAAATGTTTGATCCTTTGAAACATGATCAAGCCAGTTTTT TGAAATCATTTAATTTCTTTCAATACTGTCATAATTTCAGAAATTGGATTGA ATTGCATCTGAAAGCTACATCTTGATTGAGGACTTGAGGTGGTAATATTACT TGGAATGTATGAGTATTATGAGATTTATTTGCATATTTTCTTTGTAGTCTGTG AATGCTGGAAATGAAAAAGGAAACAACTTTGAAATATTTTAGTCAAAAAAC CATGTCATTGGTTTCATAATACAATGTCTCCAATAGGAATTCTATTTAAACT CTTGGTTTATGAGATCACATTTAAAGACTGGATTGATGTCTGTGACATAAAG TTTTAATTTTTTGCCTCATTCAAATTTATGAGACTTCAAAGTCATAGATGTTT TAAATTTTGGTAAGGGGTAACTGGGTGTTATGAAACCTAAAATGTAAGTTG ATTTTGCATTGGTAATTTGGAAATAAGATTTATTAACATTCCCTGTATTTAG TATTTTATATTCATGCACAAAATTTTTATTATCTTAAATAGGACTCAGTGTA TATTATAAAGATTTTTCTTTTTTGTGTTTTCCTTCCCTGTCATTCCCTTTATAA TTTCACAGTCACTTGCTATGAAGTCCTCCCTCCTTTTTGATTATGCAGCATTC AATTTCAGAAATCTATGAATGAGAAGGCCTTATACCTAATTTTCTGTACAGG ATCACATCTGGCAGTCCCAGGAGAAGTGAGCTGATTGCTTTTGATATCTCTT TCCCATGGCCCTAGGTAAATTATACTCTAAATTTATTTATTTTTTTTGAAACA GAGTCTTGCTTTTGTTGCCCAGGTTGGAGTGCAGTGGGGCTATCTCGGCTCA CTGCAACCTCCGCCTCCCAGGTTCAAGCAATTTTCCTGCCTCAGCCTCCCGA GTAGCTGGGATTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGTATTTT TAGTAGAGACGGGGTTTCACCATGTTGGTCAGGCTGGTCTCAAACTCCTGA CCTTGTGATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCCACCGCACCTGGCTATTATTTTTAACTTGGTTTTCATTTCTGGCATAGAG ACTAATTTGGGTCTAAGTTATTCCCATTCCTGCTTTGATTTGCTGATTTTTCA AACCTGAAGTCCAAAGTTACTGTTTTTGGGGTTTGGGGACTTGGGGAGTATT TTACTTTTTTTTTTTTTTTTTTTTAAGAGACAGAGTCTTGCTTTGTTGCCCAG GTTGGGGTGCAGCGGTACATTCATGGCTCACTGCAGCCTCAAATTCCTGGA TTCAGGCAATCTTCTCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCAT GCGCCACCATGCCTGGCTAATTTTCTTTATTTTTTAATTTTTTGTAGAGACAT GGTCTCACTTTGTTGAGCAGGCTGGCCTCAAACTCCTGGGCTCAAGTGATCC TCCTGCCTCAACCTCCCAAAGTGCTAGGATTACAGGTGTGAGCCACTGTAC CTGGCCTGTTTACTTTTTAAAAATTTTTTTGTTTGTTCTTTCAAACAGTATTT CAGAAAGCTTGGGAAAAGTTACCCTGGAAAGATTTCCTTTGCTAGTGGGTT TTCATTTTCAGGTAAAGACTGCTTTCCTTTTTTTTCAGTATCTTAATAAACTT CATAGCTTTCCTTTAGTAACAGTGTTCATTGAACTACAGCAATAGACTATCT TCGGTTTTCTGACCTCTTGTTTCAATTCCCCTTAAGTCCTGTGCCAGTTATGC TCCTACCAACACAGAGTTTCCTGTCCTCTAATGTTTAAAATAGTATTTACTG TTCTGAGCTTTATCCTCCCCCGTTAAGCATAAAGAACACTGGTCTGAGAACT AGGAGACCTAAGTTCTAGTCCTGGCTTTCCTGGTAACTTAAGCGTTATGCCC TTTGACAACTGTCTTCATGTCTCTGCTTGTTAGCACTCTCATCTGTAAAATG AAGAGGTTGGCCCAGGTCTTCTCCAACTCTGATTCTGTAATTTGGACTCTTG GTTCCAAAAATATTGATTTCCCCACTCCAACCACCAAGAGAACTATTTACCC TGTTTGTAGTGTACACAACCTTTTCTTTTGTAAGTCATATTTACCTAGATTTT GTTCAAGAAAATCTGGGTCCCACTTAGCTGTTTTAGAAACTAGTACAGACA GAGACTCTCCTGAGGAAATTAGAGCTTTTATGATTAGAAACATGCTTGTCTA AAAATGAGGGTCTTAGAAATCACAACATTGACCCTTATGATGTTGCCCCTT AAGCTAATAGTGTAATTCCTTACTGGTAGTTAAAAATCTAAAGTGGACTGA AGTGATCTTGAATCTTCAAAGAGAGGAAAACTGTGCTGGAAAATGTTATTG TTTCATTGATGCCTTCAAAAAAATGCGTATTAAACAAAGACTATACTCCAG ATTTTCTTCTGGGCATTGGGGAAGCAAACAAAATAGACTTAAAAATCCTCA TGTTCATGAAGCTTACATTCTAGTAGAAGGAGTAAGGCAATAAACATAAGT AATTTATGTTAGAAAATGTTAAGTAGGATGGAAAAGTGTAGATTATGGTAA GGTAAATCTTTTGTTTGTTTTCTTAAGAGAAGAACAATGTTTAAAAGAGTGA TCAAGCAGGGCATGGTGGCATGACCCTATTAGTCCCAGCTACCTGGGAGGC CGAGGTGGGAGGGTCACTTGAGCCCAGGAGTTTGTGGCTGCAGTGAGCTGT GATTGCACCACTGCACTCCAGCCTGGATGGCAAAGCAAGACCTCGTCTCTG GAAAAAAAGAAAAGAAAAAGTGATGATCAGGGTAGGCTTCATTAGGAAGG TCACATTTGCATGAACACTTTGCCTTTTCTTTCTTTTTATGAAAGTTTTAAAC ATAGTTTTTTTGTTTTTTGTTTTTGAGACGGAGTTTCACTCTTGTTACTCAGG CTGCAGTGTGGTGGCAGGATCTCAGCTCACTGCAACCTCCACCTTCCAGTTT CAAGTGATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCATGTG CCACCACACCCAGCTAATTTTGTGTTTTGAGATGGGGTTTCACCATGTTGGT CAGGCTGGTCTCGAACTCCTGATTTGAGGTGATCCGTTGGCCTCGGCCTCCC AAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCTAAACATACAG TTTAATAAATCCTCCTTGTACCTTACCCAGCTTCTGTATTTCTTTAATCAAGG GAGAAGAATTATCTAAAAGGACAGTTGCCCAATGGGCTTGAGCTGATGATA GTGGCAAAGAATTTCATTTTTTAAAAATGCATACCACCTGCCCTTTATAAAA AAATTTAAACCCTAATGTATTTAATTTTATAATTCATAAAAATTTAAATATT GGAACTAAGAACAGAGCAAAGCAAAGGGAAAAAGCACTCCTTTGTTTTCA AATTGCACAAACTGTCCCTGGAGATTCTGATAGTCTCTCATCTCTCTTAACT ATCACTGTAAACAACATAGAAAGCATAAGACTGCAAGAAGTCAGTTATACA CAAAACAAAATGAAGCACAGTGGAATTTTCTCTTTCTTTATCTGTATATTTC TGAAGTTGGTAAAGCAACTATCTTCTCTATTTTACAGAAGAGAAAGCTGAG ACCCAAAAAGCTATTCATAGTGATAGAGCTAGAACTAAAACTCAGATCTCC TCATCTCAGCCCAGTCTTCTCAGTAGCTCAGACTGCTTTCTATAATGAACAA GAAAGAATAATTAGGGATTTGTATTTTGGCACAAAACAGTATCAAATTTTT ATTGTAAAAATCCACAAATCTGACATTTTATCTTTTATTCTAGCCAGGATGT ATTCTTCATTTGCATGTGTGTGTTTCTCTTAGAAAGTGGTGCTCTCAAACCTT TCAAAGCACAGAATTTATTGTACCCTCTTTATTTTTACCAAATTGAAACGTT TCAGGATTTCAGAAGCAAAGTGCAATCCAATTGTGGCTGGAGTTTTCCTGA TAGAGGATCCGGGTGGTTCCCTCCCCTCCAACTTCTGGCTACTGCCCTTTAT TTCCTTTGTGCAATAGAATTCCCTGAAACAGATTATGTCGTAATTATACTGA TTTAGTCAGGATAATGGGAAAAGCGACAAATCGGATTTATGTATTAGGTAT TATGGAGCTTTCTTTAGCACTCTCCTCCAAGTTTAATCTCTGACATGTGTGA TATAGTAACTTTCTGTCTCTGAGAAGCAGTTTGGACCCAGCTGAAAAATTTT ATTTATGGAGACTTGTAATCAGCCTGATATACAGAGAACACTCTGGACTGG AAATATAGTCAGGTACCAAGGTCTGCTAATTTGGCCATTGCCAGTGATTCA AAACCACCTCCCCACCCTGAGTAAAAGATTTGATATGAATATGAATGCTAT GAGTCTCCTGGTGATGTTTTGGGTGTATATGTTCCTGTGTGTGTTTGGAAAT CATAGAGGGTATTTACCTTGAGGGCTCTTTTGTTGACCTTATTTATTTGAAA TTCTTATTTTATTTGTAATGGCATATGTATATTTTTGTGATGCTACATGCAAT CTCTGTGTATACTTTTTGTATATATGTATACATATTTGTAAATATATTGGTAT GCAGTGATACAGTATGTGTATATTATGTACCCATACCCATTGTGGGCTGAAT TTATTTAAGTTCTGTGAGGACATCCTAGTGGCATTGTTCATGCTGCTGTAAT TAGGTTGTGGCTGTATCTCATTCATAAGCCTCTATTTTGAGAGGCTTGTGTT TGGATAAAATGGGCTAATTTGGAGTTGAAATTAGGATATGAAGATCTTAAC AGAAAGCTAGATATTTATTCTTAGCTTTAAAATCACCTGCAAATTTTTATTT AAACTGATGATAAATTAGTGATATAACCTGAAAAACCTAAGTATGTGAAAC TGAGACACCAGCAGATTCTTAGGCTGTAGTAGTCCTTTATTTTCTTGATCCA TATTTAAGTATTATTACTGAGTAGTAAATTATGTATATTGGGGCTTAATAGA GAGGCTGTGGAAAAAAATTGCTTTAATCACATTTAAAAACATAGGAAAATG TCCATTAAATAGGGGAAATATATTCCCAGTTGTCATTTTTATGCCTCATACT GAATTTTGATTTTGGAACAATTCTTTTTTCATCAGTGTTTTATGTGTCTCTAT GAGGCAGAAAAGGGGGCATTAGCTAAGGGATGGCCTAACCTAAGTAGGAT AGGATTTAGTGAGGAACGGGAGGTTGTTAATTTGTATATTTGCAGCAGCTA TGATTAATTTAGTCCTGTCTTGGCATTTCCGGCTACAGATTTTTTCTTACTGG ACTTGCATATCAAAGGTGAGTAGGCTCATCTGAGAAAATGCTTCCACTGAA TAAAATGCCTTCACTCGTATTGCTGTGTCTCTATGAGACCACTTGTGTTCTG CAAGTTGATGATATATTCGCACATGAAGTAGAGTTTTTAATATTAGATGCAT GGTGTGCTATAAAAATCTGGGCCTTCAAACCTCTCCCAAGGATGATAGGGT TGGGGAGGATAAGAGGATAGTAAATACGTGCAATGCCAATTTGTGAACCTA TAGAATGTTGCCAAGTATCAATGTTTGGTTACTTCAGTTGACATATTTATTT GCATGAAAGAGTGTAGGAGATGTTTAATATACACTTAAATACATTCACTGC AGAAATTAAGTAGAGGTTATTTTTGCATGATAAAATATAACTGCAAAGCAA CTTTTTACACCGTATTCTTTGGAAGATTAAATCTATCTGATCCAATATTATCT TAAAATAGAGAAATTATCTCAGGAGTCTGTTTTACCACCCAAAAAAATGTT ACATTTGCTGATTCATTATATTTTAAATAAAACAGCCAACTATTCATAAGAC TTTTCAATTATAGTATTAAATTCAGAAATAATTATAACAGCATTTTTCTTGA ATAAATATTAAAATTTGGTAATTTATTATTTCTGAAAAATCAGTGAAAACAT CCATAGGATCTGATGGTTTGTTGTTTGAATAACCAAATCATTGTTTTTGCAC TGGAGAGTAGTAGAGCAGATATTATACCATTTAAAATTCATGGAACTGACT CAGGCTCCTTGTGGATATTAATTTGAGGACAGTAGTGGTAATCAAAAGTAC AGTAGAAAACACTTGACATTGTGAATGTGACCTCTGACCCCAACCGTTGTA AAGCCAATAACTTTGAGGGTGAATAAGGTAACACTTGCTTAGAAAACCCAG CCCTTTCCCCCAGTCTCCTGCGCTCTTATACATTGATACTTTACAACTATTTT TGCTGTACCTCTCAGTCTTTCCTGGATAATGGGACCACTTAAAAAAAAAAG TGATTCATCTTCCTCAAACTAGAATTTCAAAGCCTAATACTACACTATGTTC CAGCTTCACTGAGTTTTGAACAAAAAGACTTAAGCATGCCTTGTGTTTAAG GAAAAATAATTGATGTGTGAATGGAATCAATCACCTATTGACGGGAAGGGT GTCAGGATGATGTAGGGTGATATGCCTTTAATTGGATAAAGAGAACTGTAT TAAGTATAACTAATTTAATAACTGATTGAAGCACCATTCTTAATTTTAAAAT ATTTTTGTTAATTTCTTTTGTGGTTTTAAAAATTAATAATTTTTTTTTTTTTGA GATGGAGTTTTGCTCGTTGCCCAGGCTGGAATGCAATGGCGCGATCTCAGC TCACTGCAACCTCCGCCTCCTGGGTTCAAGAGATTCTCCTGCCTCAGCCTCC CAAGTAGCTGGGATTACAGGCGTGTGCCACCACGACCAGCTAATTTTGTAT TTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCT GACCTCAAGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG TGTGAGCCACTGTGGCCGGCCTAAAAAAAATTCTTTTTAATAGTTATCAGAC TACTTTAACCAGTGCCATGTTTAAACATACTTGGACAATAGACTCAGTTTTT TTAATAGTTTGAAGTACATTATATTAAAACTACAAACTCACTTATTCAAGCC TAAATTTCATCATAGACTATAAATTGGGTATCAATTTCCTATTTTGGTGGAC AATTCCAGTCTGTCTACTACGACAATCATCTTTTTAGGTGTAATATTGTTTA AGACATAGGTAATTTTAGGTTTTATACTTTTCTCCTAGGCTTATGGAATGAA AGCTAATAGGATATCACTTTCAGAATGAAATAGGGAATTATGGCTAGCCTT CTTATAGGGCTGCCGTAAATGATACTTAAATGTTTGTTATATCACTGATTTT CTTTTCTCTTCTGAAGCTGTTGTGAATGTCCACTTTGCCATGATTAAAAGTT GAGATTTGTAAACATTACAATTTGAACCATAAATTTTCTCAAACATGAAATC AGTATGAATAAGTATAAAATTTGAAATGATCATACATGAGAATCCCAAAAG TAAATACTTCCAAACCATAGAGGGATAACCACTGTATTTTTAAAAAGCTTA TTTCCACCCTTAAAGAAGCATGCTACTAATTGCTTTTTTTCTAAATTAAAAC TATGTACTGTGGTAAATTAAAAATCTGCAGGAAAAATTGCTTAGTGTTTTAG CACAATAAGAATTTTTATTACTCAGGAGTTGGAGACCAGTCTGGGCAATAC AGTGAAACCCTGTCGCTACTAAAATACAAAAAAAAAAAAAAAAAAAAAAA AATTAGCCAGGCATGGTGGTGTGCGCCTGTAATCCCAGCTACTTGGGAGGC TGAGGCAGGAGAACTGCTTGTAACCTGGGAGGCGGAGGTTGCAGTGAGCC GAGATCGTGCCATTGCACTCCAGTCTGGGTGACAGAGCAAGACTCATTCTC AAAAAAAAAAAAAAAAGGAATTTTTATTACTATTTCCTGAAGAATGGTTTT TGTTAACTTGTTACTGTATCATTAAAAAGACCTTCTAATGGTTCAGTACAAT AATCTAGAACTTGATTTATGTGGCTTTTTATAGTTATCTGAATGCATTCCTTT TGCCACATAGACCATATGGCTAGTTCTCCAACTTTTTTGCTTATTTTTAATAA ACCTTGCTGTTCAACAATCAGAGAAACCTTTAGATTTTGGATGATTCTTCCA GTTGAGGTAGAAACATCTTAGATAATAGGAAAGGCAAATACAAAGTCCTA ACATTTTCATAGTAGAGTTTACAAGTAAAATAACTTATCCATATAGGTTATC TTCGTTGTGTAGCACCAGTATAAATAGTGATTTCATTAATCATTGAATCAGA TGAAGCAGTTATAAATCACTTTTTACTTTGTGCTAAGAATTATTGTAATTTC AGGACACTTTATTATTTCCTCTGAGCAGTTTCCATTGGAAGGTTGAGTTTCC CTTTTTTAAGTTCTAATCATCACTAAAGGTTAAGATAATCAAATAGGAGTTA AAATAAGTTATGTTTGATCTTTTTCCCTTGAAAATAATGCTGAACTTATTGT CTACATTCTGATTATTAGGCAGAAATGCACTTGTTTAAATCATAGAAGTAAT TCATTTGGAGGATATAATTACTCGATTTTCTAGTGGTGTGAAATACTTTTTA ACAATTGTGCTTGTCTGTAACTGAAATGTTATAGAATTTTAACACTATAGGG ATTATAGAGTTATATTAGCTCTCCTCAAGAGACTGAAGCACAATATTTTTCA TGTAACAATTCTTATCCAAGTGCTGCTAATCTGTCGTGCAAATAATGAAGCT ATTTGGTTGCCTATTTAGCTATTCACAAATCACTGTAATCTTTGAAACAATC TTGTCGTTCATTTGTATTAATATTTGGATATTGTGAGTTAATACTTTAGAAA AAAATCCATCAACTCAGCCCCGTTAGCAAAACTGTTTGGATTCATAGTTTTT ATATGTGTTAACAGTAGAATAAATTTTGAAGGGGCTATTTACTACCAATGA CTAAGGGGAAAATTATACTGTCACTATCATTTGACTTGAACATTTGTGGTAT TGTAAAAGTCTTGTCAGTTGTGTTCTAAATTGCTTAAGCCATACGTTCTCTT AAACAGGATGTTTTTTTCTTCCTTTCCAGCAGCCTTTTTCTTCTTTGTCTGTT ATGGTTAATACTCCATAGATTTTAGAAATTGAGAAGTTCTTGAAACATTTTA TTTTCTTGAGTTCATCACTTTTGACTCTTGTATGAGATGTGATTTGTCATAAA AGATAGCCTTCCACTACTTCACTAAATGAATTTCAGAGTAAACACTGTGATT CTGCAGAGCGGATTCAGTAGGCTTTCCAATGTTTTCTCCTGCTATACAGTGC CTACCACCTTGAGGGCACTTCAGTACTAGAGGATGAAAACTGAAACGTTGT TTTGATGTTTATTGAATAACGAGATTAGAGAATATTTGATTTTTGTTGTCAG TGTATTAAAGAAATTTTCACATTGATAAATGTTCTCTAGGAATGTGTCTACA TTCATCAGGTGTGAACTCTTGTACATGAATTTTGTACCTTGAATCCACATAT ATATTAAGTGTATCATCAATATAAAAATAAACATTATTTGCTTAA ATRX-> ATGACCGCTGAGCCCATGAGTGAAAGCAAGTTGAATACATTGGTGCAGAAG SEQ ID RPS6KA6 CTTCATGACTTCCTTGCACACTCATCAGAAGAATCTGAAGAAACAAGTTCTC NO:71 CTCCACGACTTGCAATGAATCAAAACACAGATAAAATCAGTGGTTCTGGAA GTAACTCTGATATGATGGAAAACAGCAAGGAAGAGGGAACTAGCTCTTCA GAAAAATCCAAGTCTTCAGGATCGTCACGATCAAAGAGGAAACCTTCAATT GTAACAAAGTATGTAGAATCAGATGATGAAAAACCTTTGGATGATGAAACT GTAAATGAAGATGCGTCTAATGAAAATTCAGAAAATGATATTACTATGCAG AGCTTGCCAAAAGGTACAGTGATTGTACAGCCAGAGCCAGTGCTGAATGAA GACAAAGATGATTTTAAAGGGCCTGAATTTAGAAGCAGAAGTAAAATGAA AACTGAAAATCTCAAAAAACGCGGAGAAGATGGGCTTCATGGGATTGTGA GCTGCACTGCTTGTGGACAACAGGTCAATCATTTTCAAAAAGATTCCATTTA TAGACACCCTTCATTGCAAGTTCTTATTTGTAAGAATTGCTTTAAGTATTAC ATGAGTGATGATATTAGCCGTGACTCAGATGGAATGGATGAACAATGTAGG TGGTGTGCGGAAGGTGGAAACTTGATTTGTTGTGACTTTTGCCATAATGCTT TCTGCAAGAAATGCATTCTACGCAACCTTGGTCGAAAGGAGTTGTCCACAA TAATGGATGAAAACAACCAATGGTATTGCTACATTTGTCACCCAGAGCCTT TGTTGGACTTGGTCACTGCATGTAACAGCGTATTTGAGAATTTAGAACAGTT GTTGCAGCAAAATAAGAAGAAGATAAAAGTTGACAGTGAAAAGAGTAATA AAGTATATGAACATACATCCAGATTTTCTCCAAAGAAGACTAGTTCAAATT GTAATGGAGAAGAAAAGAAATTAGATGATTCCTGTTCTGGCTCTGTAACCT ACTCTTATTCCGCACTAATTGTGCCCAAAGAGATGATTAAGAAGGCAAAAA AACTGATTGAGACCACAGCCAACATGAACTCCAGTTATGTTAAATTTTTAA AGCAGGCAACAGATAATTCAGAAATCAGTTCTGCTACAAAATTACGTCAGC TTAAGGCTTTTAAGTCTGTGTTGGCTGATATTAAGAAGGCTCATCTTGCATT GGAAGAAGACTTAAATTCCGAGTTTCGAGCGATGGATGCTGTAAACAAAGA GAAAAATACCAAAGAGCATAAAGTCATAGATGCTAAGTTTGAAACAAAAG CACGAAAAGGAGAAAAACCTTGTGCTTTGGAAAAGAAGGATATTTCAAAG TCAGAAGCTAAACTTTCAAGAAAACAGGTAGATAGTGAGCACATGCATCAG AATGTTCCAACAGAGGAACAAAGAACAAATAAAAGTACCGGTGGTGAACA TAAGAAATCTGATAGAAAAGAAGAACCTCAATATGAACCTGCCAACACTTC TGAAGATTTAGACATGGATATTGTGTCTGTTCCTTCCTCAGTTCCAGAAGAC ATTTTTGAGAATCTTGAGACTGCTATGGAAGTTCAGAGTTCAGTTGATCATC AAGGGGATGGCAGCAGTGGAACTGAACAAGAAGTGGAGAGTTCATCTGTA AAATTAAATATTTCTTCAAAAGACAACAGAGGAGGTATTAAATCAAAAACT ACAGCTAAAGTAACAAAAGAATTATATGTTAAACTCACTCCTGTTTCCCTTT CTAATTCCCCAATTAAAGGTGCTGATTGTCAGGAAGTTCCACAAGATAAAG ATGGCTATAAAAGTTGTGGTCTGAACCCCAAGTTAGAGAAATGTGGACTTG GACAGGAAAACAGTGATAATGAGCATTTGGTTGAAAATGAAGTTTCATTAC TTTTAGAGGAATCTGATCTTCGAAGATCCCCACGTGTAAAGACTACACCCTT GAGGCGACCGACAGAAACTAACCCTGTAACATCTAATTCAGATGAAGAATG TAATGAAACAGTTAAGGAGAAACAAAAACTATCAGTTCCAGTGAGAAAAA AGGATAAGCGTAATTCTTCTGACAGTGCTATAGATAATCCTAAGCCTAATA AATTGCCAAAATCTAAGCAATCAGAGACTGTGGATCAAAATTCAGATTCTG ATGAAATGCTAGCAATCCTCAAAGAGGTGAGCAGGATGAGTCACAGTTCTT CTTCAGATACTGATATTAATGAAATTCATACAAACCATAAGACTTTGTATGA TTTAAAGACTCAGGCGGGGAAAGATGATAAAGGAAAAAGGAAACGAAAAA GTTCTACATCTGGCTCAGATTTTGATACTAAAAAGGGCAAATCAGCTAAGA GCTCTATAATTTCTAAAAAGAAACGACAAACCCAGTCTGAGTCTTCTAATT ATGACTCAGAATTAGAAAAAGAGATAAAGAGCATGAGTAAAATTGGTGCT GCCAGAACCACCAAAAAAAGAATTCCAAATACAAAAGATTTTGACTCTTCT GAAGATGAGAAACACAGCAAAAAAGGAATGGATAATCAAGGGCACAAAA ATTTGAAGACCTCACAAGAAGGATCATCTGATGATGCTGAAAGAAAACAA GAGAGAGAGACTTTCTCTTCAGCAGAAGGCACAGTTGATAAAGACACGACC ATCATGGAATTAAGAGATCGACTTCCTAAGAAGCAGCAAGCAAGTGCTTCC ACTGATGGTGTCGATAAGCTTTCTGGGAAAGAGCAGAGTTTTACTTCTTTGG AAGTTAGAAAAGTTGCTGAAACTAAAGAAAAGAGCAAGCATCTCAAAACC AAAACATGTAAAAAAGTACAGGATGGCTTATCTGATATTGCAGAGAAATTC CTAAAGAAAGACCAGAGCGATGAAACTTCTGAAGATGATAAAAAGCAGAG CAAAAAGGGAACTGAAGAAAAAAAGAAACCTTCAGACTTTAAGAAAAAAG TAATTAAAATGGAACAACAGTATGAATCTTCATCTGATGGCACTGAAAAGT TACCTGAGCGAGAAGAAATTTGTCATTTTCCTAAGGGCATAAAACAAATTA AGAATGGAACAACTGATGGAGAAAAGAAAAGTAAAAAAATAAGAGATAA AACTTCTAAAAAGAAGGATGAATTATCTGATTATGCTGAGAAGTCAACAGG GAAAGGAGATAGTTGTGACTCTTCAGAGGATAAAAAGAGTAAGAATGGAG CATATGGTAGAGAGAAGAAAAGGTGCAAGTTGCTTGGAAAGAGTTCAAGG AAGAGACAAGATTGTTCATCATCTGATACTGAGAAATATTCCATGAAAGAA GATGGTTGTAACTCTTCTGATAAGAGACTGAAAAGAATAGAATTGAGGGAA AGAAGAAATTTAAGTTCAAAGAGAAATACTAAGGAAATACAAAGTGGCTC ATCATCATCTGATGCTGAGGAAAGTTCTGAAGATAATAAAAAGAAGAAGC AAAGAACTTCATCTAAAAAGAAGGCAGTCATTGTCAAGGAGAAAAAGAGA AACTCCCTAAGAACAAGCACTAAAAGGAAGCAAGCTGACATTACATCCTCA TCTTCTTCTGATATAGAAGATGATGATCAGAATTCTATAGGTGAGGGAAGC AGCGATGAACAGAAAATTAAGCCTGTGACTGAAAATTTAGTGCTGTCTTCA CATACTGGATTTTGCCAATCTTCAGGAGATGAAGCCTTATCTAAATCAGTGC CTGTCACAGTGGATGATGATGATGACGACAATGATCCTGAGAATAGAATTG CCAAGAAGATGCTTTTAGAAGAAATTAAAGCCAATCTTTCCTCTGATGAGG ATGGATCTTCAGATGATGAGCCAGAAGAAGGGAAAAAAAGAACTGGAAAA CAAAATGAAGAAAACCCAGGAGATGAGGAAGCAAAAAATCAAGTCAATTC TGAATCAGATTCAGATTCTGAAGAATCTAAGAAGCCAAGATACAGACATAG GCTTTTGCGGCACAAATTGACTGTGAGTGACGGAGAATCTGGAGAAGAAAA AAAGACAAAGCCTAAAGAGCATAAAGAAGTCAAAGGCAGAAACAGAAGA AAGGTGAGCAGTGAAGATTCAGAAGATTCTGATTTTCAGGAATCAGGAGTT AGTGAAGAAGTTAGTGAATCCGAAGATGAACAGCGGCCCAGAACAAGGTC TGCAAAGAAAGCAGAGTTGGAAGAAAATCAGCGGAGCTATAAACAGAAAA AGAAAAGGCGACGTATTAAGGTTCAAGAAGATTCATCCAGTGAAAACAAG AGTAATTCTGAGGAAGAAGAGGAGGAAAAAGAAGAGGAGGAGGAAGAGG AGGAGGAGGAGGAAGAGGAGGAGGAAGATGAAAATGATGATTCCAAGTCT CCTGGAAAAGGCAGAAAGAAAATTCGGAAGATTCTTAAAGATGATAAACT GAGAACAGAAACACAAAATGCTCTTAAGGAAGAGGAAGAGAGACGAAAA CGTATTGCTGAGAGGGAGCGTGAGCGAGAAAAATTGAGAGAGGTAAATGG TCTTAAAATGGTTGATGAGCCAATGGAAGAGGGAGAAGCAGATTCTTGTCA TGATGAAGGAGTTGTTAAAGAAATCCCTATTACTCATCATGTTAAGGAAGG CTATGAGAAAGCAGATCCTGCACAGTTTGAGTTGCTCAAGGTTCTTGGTCA GGGGTCATTTGGAAAGGTTTTTCTTGTTAGAAAGAAGACCGGTCCTGATGC TGGGCAGCTCTATGCAATGAAGGTGTTAAAAAAAGCCTCTTTAAAAGTTCG AGACAGAGTTCGGACAAAGATGGAGAGGGATATACTGGTGGAAGTAAATC ATCCATTTATTGTCAAATTGCACTATGCCTTTCAGACTGAAGGGAAACTGTA CTTAATACTGGATTTTCTCAGGGGAGGAGATGTTTTCACAAGATTATCCAAA GAGGTTCTGTTTACAGAGGAAGATGTGAAATTCTACCTCGCAGAACTGGCC CTTGCTTTGGATCATCTGCACCAATTAGGAATTGTTTATAGAGACCTGAAGC CAGAAAACATTTTGCTTGATGAAATAGGACATATCAAATTAACAGATTTTG GACTCAGCAAGGAGTCAGTAGATCAAGAAAAGAAGGCTTACTCATTTTGTG GTACAGTAGAGTATATGGCTCCTGAAGTAGTAAATAGGAGAGGCCATTCCC AGAGTGCTGATTGGTGGTCATATGGTGTTCTTATGTTTGAAATGCTTACTGG TACTCTGCCATTTCAAGGTAAAGACAGAAATGAGACCATGAATATGATATT AAAAGCAAAACTTGGAATGCCTCAATTTCTTAGTGCTGAAGCACAAAGTCT TCTAAGGATGTTATTCAAAAGGAATCCAGCAAATAGATTGGGATCAGAAGG AGTTGAAGAAATCAAAAGACATCTGTTTTTTGCAAATATTGACTGGGATAA ATTATATAAAAGAGAAGTTCAACCTCCTTTCAAACCTGCTTCTGGAAAACC AGATGATACTTTTTGTTTTGATCCTGAATTTACTGCAAAAACACCTAAAGAT TCTCCCGGTTTGCCAGCCAGTGCAAATGCTCATCAGCTCTTCAAAGGATTCA GCTTTGTTGCAACTTCTATTGCAGAAGAATATAAAATCACTCCTATCACAAG TGCAAATGTATTACCAATTGTTCAGATAAATGGAAATGCTGCACAATTTGG TGAAGTATATGAATTGAAGGAGGATATTGGTGTTGGCTCCTACTCTGTTTGC AAGCGATGCATACATGCAACTACCAACATGGAATTTGCAGTGAAGATCATT GACAAAAGTAAGCGAGACCCTTCAGAAGAGATTGAAATATTGATGCGCTAT GGACAACATCCCAACATTATTACTTTGAAGGATGTCTTTGATGATGGTAGAT ATGTTTACCTTGTTACGGATTTAATGAAAGGAGGAGAGTTACTTGACCGTAT TCTCAAACAAAAATGTTTCTCGGAACGGGAGGCTAGTGATATACTATATGT AATAAGTAAGACAGTTGACTATCTTCATTGTCAAGGAGTTGTTCATCGTGAT CTTAAACCTAGTAATATTTTATACATGGATGAATCAGCCAGTGCAGATTCA ATCAGGATATGTGATTTTGGGTTTGCAAAACAACTTCGAGGAGAAAATGGA CTTCTCTTAACTCCATGCTACACTGCAAACTTTGTTGCACCTGAGGTTCTTAT GCAACAGGGATATGATGCTGCTTGTGATATCTGGAGTTTAGGAGTCCTTTTT TACACAATGTTGGCTGGCTACACTCCATTTGCTAATGGCCCCAATGATACTC CTGAAGAGATACTGCTGCGTATAGGCAATGGAAAATTCTCTTTGAGTGGTG GAAACTGGGACAATATTTCAGACGGAGCAAAGGATTTGCTTTCCCATATGC TTCATATGGACCCACATCAGCGGTATACTGCTGAACAAATATTAAAGCACT CATGGATAACTCACAGAGACCAGTTGCCAAATGATCAGCCAAAGAGAAAT GATGTGTCACATGTTGTTAAGGGAGCAATGGTTGCAACATACTCTGCCCTG ACTCACAAGACCTTTCAACCAGTCCTAGAGCCTGTAGCTGCTTCAAGCTTAG CCCAGCGACGGAGCATGAAAAAGCGAACATCAACTGGCCTGTAA TEX10-> TGCGATCACGTGAGCACAGCAGGGAGGGGGAGGGGCCCTGATTTCCGGGC SEQ ID PICALM GGCGGAAGGAGACGCGGCCGCGTGAGGACGAGGCTATTTGAAAACACGCT NO:72 CCGGGAGCTAGAGCCTGAGGTCGGCGGCGCACGCTGTTGCCCCGTGGGCTT CTGCTCCCTCGCTTGTCTTCTCGGGCTTCTCGCCCCGGCCGCGGCCGGGTCC TCAGACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTG GCAGACAGTTTATTTGAAAGAACTACTAATAGTAGTTGGGTGGTGGTCTTC AAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTA TTCAGTATTTGGCTTCAAGAAACACGTTGTTTAACTTAAGCAATTTTTTGGA TAAAAGTGGATTGCAAGGATATGACATGTCTACATTTATTAGGCGGTATAG TAGATATTTAAATGAGAAAGCAGTTTCATACAGACAAGTTGCATTTGATTTC ACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGA AAAACTCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCT TGATTTTAATGTTAATAGCAATGAACTTACAAATGGGGTAATAAATGCTGC CTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCATACAATGAA GGAATTATTAATTTGTTGGAAAAATATTTTGATATGAAAAAGAACCAATGC AAAGAAGGTCTTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATC TCAGAGTTCCTCAAAGTTGCAGAGCAAGTTGGAATTGACAGAGGTGATATA CCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAACATT TAGCTTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGG CAACTACACTTTCCAATGCAGTGTCTTCCCTGGCAAGCACTGGTCTATCTCT GACCAAAGTGGATGAAAGGGAAAAGCAGGCAGCATTAGAGGAAGAACAG GCACGTTTGAAAGCTTTAAAGGAACAGCGCCTAAAAGAACTTGCAAAGAA ACCTCATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGA GGGATAATGACTGCACCAGCCATTGACATATTTTCTACCCCTAGTTCTTCTA ACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCAGCAGCCAACTT TTCACCCATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATG GGGAGATCCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCATTCCAAGC TTAAATCCTTTCCTCACAAAAAGTAGTGGTGATGTTCACCTTTCCATTTCTTC AGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAATGTTTGTTGGA TTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTG ACTTTGAATCTGTGTTTGGAAATAAATCTACAAATGTTATTGTAGATTCTGG GGGCTTTGATGAACTAGGTGGACTTCTCAAACCAACAGTGGCCTCTCAGAA CCAGAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATCTGATGAC TTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAA CCACTAAGAATGATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTG GGGGATCTAACTGGCAACCAAAGGTTGCACCAACAACCGCTTGGAATGCTG CAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGGCA TGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGC AACCAACCTTAATATACAGCCAGCCTGTCATGAGACCTCCAAACCCCTTTG GCCCTGTATCAGGAGCACAGATACAGTTTATGTAACTTGATGGAAGAAAAT GGAATTACTCCAAAAAGACAAGTGCTCAAGCAGCAAAATCCTTACTTCCAG CAAAATCCAAACTGCTGTCTCTTAAATCTCTTAAACTCTCTTCTTCCATTAG AATGCTACAAGTAACTCAGTGAAGGCCCATGAAGGAAATTGGGACTAGTTT ATAGGAGAACGTATCAATACAGTTTATAAAGCCAAGAATTGCTATGATTTA AGACTAAGATCTGTCTTTTTGGTGACTAACCCTTCAATTCTTTCAACTCCTGT TAATACCCATAATCAGTAACCTATCAAGAAAAGCCCTTATTTGGAAAGTGT GAAATTTGTATTTGGAAAAGCTGCCTGGAGAGAAGAACTGTGTCCTTTACT GTATTTCAACAGGACTCTTTTGGGGGATCAAAATTAAAATTCCTAATTATGC ATTATCTTTCTTTTCTCCAGTCCTCACAAATACAGAAACAATAACTGAAATT AACTTTTCTTTTTTTAAAAAAAATTATATTCAGTTTGCAGTAGACATTCCTTA AGTATTTGTATTTATTTATGATTATCAATTTTACATAACATTAATATTGTATC AGACCTCCTTATGAAAATGAGTATGGATGTGCACAGTATGTTTGATTTTTAT CCACAAGAATGAATCTGATTCAGAATGCTTTTCTCAGCTGACATACAGAGC ACTAAATATTTTAAGGCAAGTCCATAGGTCTGAATCTCTTAAGAATTCTCGG CCTCTGTGGGATTTAGGGAAGCATTATAAATGCATTAATCCTTATAGTCAAT TCTGTGCCTAGGATTTTGCCAGGGAACAGTTCACTGACTAGGAAAAGCACT ACATTTTAAATTCAGCATTAGTGCATTGGGAAGGATCTTTACTGCTTTGTGC TTGGCATGTCATTATTTTCCATTTGACATTAGGGCCTTTCCAAAATGAATGT GAGGAATTGCTTTCACTTCAAGACTTTCCTTCTTTTCACTAAAACTCTAGAA GGTGTTACAAGGGGGAGGGAAGGGGGGCAAAGTCCTTGAACATTTTCTTTG GCTCGTGCCATGTTATGATCATATACCTTTTAAATAAGGGGAAATAGTATCT TTAAAGTTAATGTCTAGCCAAGAGTTTAGTAAACGAAGAATTAAACTGCAC TGTTGATCGGTGCTTTGTGTAAATACATCTTTAACATTTGGGTGGAGAGGGG CCTTAAGAAGGACAGTTCATTGTAGGAAAGCAATTCTGTACATGAGTTTAA GCATTCTTGTTGCATTGTCTCTGCAGATTCTATTTTTGTTTACAATATTAAAA TGTATGTTAGCAAAATGGGTGGATTTTCAAATAAAATGCAGCTTCCACAAA AGTTTTGTTATGGTATTCTGGTCTGAGATGCATTTTCATTTTTCCTTTCTCTTT TTATTATCAATATTGTCATTTTTCCCTAATAAAATATACCCAGGTGATTATA TTTGTTGATCTAATAACATGGAAGGTTTGTTTTATATGAATTTTCAAAAAGA TGTCTCTTTACACTTTTTGTTACCTTGTAGACTCTTATTGATAAATGCAACTA CTTATTAAAATTGTTCACTTTTTGTCTTTTGATCAGATGCCTTTAGTCAGGTA AGTTTAAGGGAAAATACGCAGTTTAATGTTTTGGTACATATAATTATGTCTG CCAAAGAAACCTTTGATTGTATCATATTGCCTATTTAGTAGTGCATAGGGTT CAGAGTACATGATAAAGGATCAAAAGCTTTGCATTGATAAGTGTCTCATAA TATTTGCTGTGATTGGAGAAAAAATGTAGTCGTAGCCAATAAATTTTATCA GCTTTTAAGTTTCAGTATTATTAAACCATTTTCATATAAACTGG FGD5-> ATGTTCAGGGGTCCGAAGCCCCCCATTGCCCCCAAGCCCAGGCTGACTGCC SEQ ID BTC CCAAACGAGTGGAGAGCCAGTGTGTACCTGAATGACAGCTTGAACAAATGC NO:73 AGCAACGGGCGGCTGCCCTGTGTAGACAGGGGGCTTGATGAGGGGCCCCG GTCCATCCCAAAGTGCTCTGAGTCGGAGACCGACGAGGATTACATCGTGGT CCCCAGGGTTCCGCTGAGGGAGGATGAACCCAAGGACGAGGGCAGTGTGG GGAACAAAGCCCTGGTGTCTCCCGAGTCCTCTGCGGAAGAGGAAGAGGAG CGTGAAGAGGGAGGCGAGGCATGTGGCCTGGAGGGTACAGGAGCTGGTGA GGATTCAGTGGCCCCTGCTGCTCCGGGTGCAGGAGCGCTGAGCAGGGAGGG TGAGGAAGGCACAGACCTTGCTCTTGAGGATGAAGGGGAGGGCTGCGCTG ATGAGCCAGGGACACTGGAGCAGGTGTCCAGAAGTGAGGAGGAAGAGAAG CTAGTGCAGCCACACAGGGAGTGCAGCCTGGAGGACAGTGGGCCTTGGGCT GGAGAGGGGGTCTTCCAGAGCGACCTCCTCCTGCCTCACATCCATGGAGAG GACCAGGAGCCCCCCGACACCCCCGGGGAGGCAGAGGAGGATGATGAGGA AGGCTGTGCCAGCACAGACCCAGCAGGGGCAGATGAGGGTTCGGGTCCTG ACAGGCCCACGGAGGACATGGGACAGGATGCTGAGGACACCAGTGAGGAG CCCCCTGAGAAGGAGGAGCTGGCCGGGGTCCAGGAGGCAGAGACAGCCAC AGACTGCCCTGAAGTTCTTGAGGAGGGATGTGAAGAGGCCACGGGTGTCAC AGGTGGGGAACAGGTTGACCTCAGTGAACCACCTGACCACGAGAAGAAAA CCAACCAAGAAGTGGCAGCCGCCACCCTGGAGGACCATGCACAGGATGAG TCCGCCGAGGAGAGCTGCCAGATTGTCCCTTTTGAGAATGACTGCATGGAG GACTTCGTGACTTCCCTCACAGGAAGCCCCTATGAGTTCTTCCCAACTGAGA GCACCTCTTTTTGCAGCGAGAGCTGTTCTCCTCTTTCTGAATCAGCGAAAGG TTTAGAATCAGAGCAGGCACCAAAGCTGGGGCTGCGTGCGGAGGAGAACC CCATGGTGGGGGCTTTGTGTGGCCAGTGTGGCTCCCTACAGGGTGGAGCGG CCGAGGGTCCCGCAGCCCCTGATGTGGTGGTCGTGCTGGAGGAGGAGGCCT TGGATGATGCACTGGCCAACCCCTATGTGATGGGAGTGGGCCTGCCCGGTC AGGCGGCCCCTGGAGAAGGAGGGCAGGCTGCATCGGACGCCCTGGGTGGT TATGGCTCGAAAGAAGAATTGAACTGTGAGGCAGAGGGTGGCCTGGTTCCC GCGGACAGGAAGAACACCAGCACGAGGGTCCGGCCCCACTCTGGGAAGGT GGCCGGCTATGTCCCAGAAACCGTCCCTGAAGAAACCGGACCTGAGGCGG GCTCGTCAGCCCCTGGCATTGGAGGTGCCGCAGAGGAGGTGGGAAAGACG CTTTTGTCATTGGAGGGGAAGCCCTTGGAAGCCAGCAGGGCCTTGCCAGCA AAGCCCAGGGCCTTTACTTTATACCCTCGGTCGTTCTCCGTGGAAGGCCGAG AGATTCCAGTGTCCGTGTACCAGGAGCCTGAGGGGTCAGGGTTGGATGACC ACAGGATAAAGAGGAAAGAGGACAATCTCTCTCTGTCGTGTGTAATTGGCT CCTCTGGGAGTTTCTCCCAGAGAAACCACCTTCCGTCCAGCGGCACCTCCA CGCCTTCTTCCATGGTCGACATCCCACCTCCTTTCGACCTGGCCTGCATCAC CAAGAAGCCCATCACAAAGAGCTCTCCCTCACTCCTGATCGAGAGCGACTC CCCGGACAAGTACAAGAAGAAGAAGTCATCCTTTAAGCGCTTCCTGGCACT GACGTTTAAGAAGAAGACGGAGAACAAATTGCATGTGGATGTGAACGTGT CTTCCTCTAGGTCCTCTTCAGAGTCCAGCTACCACGGGCCTTCCAGGATTCT GGAAGTTGACCGGAGAAGCCTCAGCAACTCCCCTCAGCTTAAGTCTCGGAC TGGGAAGCTCCGGGCTTCTGAATCCCCCTCCTCCCTCATCTTTTATAGAGAT GGCAAGAGGAAAGGTGTCCCCTTCAGCAGGACGGTGTCCAGAGTGGAGTC CTTTGAAGACCGCTCCCGGCCGCCCTTCCTGCCCTTGCCACTGACCAAGCCA CGGTCCATCTCCTTCCCCAGCGCTGACACTTCAGACTATGAGAACATTCCAG CCATGAACTCGGACTATGAGAATATCCAGATTCCACCCCGGAGACCTGCCA GGGCTGGCGCGTTCACGAAGCTGTTTGAAGATCAGAGCAGAGCCCTGTCCA CAGCAAACGAAAATGATGGCTACGTGGACATGAGCAGCTTCAACGCCTTTG AGAGCAAACAGCAGAGTGCAGACCAGGACGCAGAAAGCGCCTACACAGAG CCCTACAAAGTCTGTCCCATCTCGTCGGCAGCCCCCAAAGAGGACCTTACG TCGGATGAAGAGCAGAGAAGCTCGGAGGAGGAGGACAGTGCTTCAAGAGA CCCCAGTGTCACCCACAAGGTGGAAGGACAGTCCAGAGCCCTTGTCATCGC ACAGGAACTGCTATCTTCAGAGAAAGCATACGTGGAGATGCTCCAGCACTT AAATCTGGATTTCCATGGAGCTGTCATGAGGGCCTTGGATGACATGGACCA TGAAGGCAGAGACACATTGGCCCGGGAGGAGCTGAGGCAGGGCCTGAGTG AACTCCCAGCCATCCACGACCTTCATCAAGGCATCCTGGAGGAGCTGGAGG AAAGGCTGTCAAATTGGGAGAGCCAGCAGAAGGTAGCTGACGTCTTCCTGG CCCGGGAGCAGGGGTTTGATCACCACGCCACTCACATCCTGCAGTTCGACA GGTACCTAGGTCTGCTCAGTGAGAATTGCCTCCACTCTCCCCGGCTGGCAGC TGCTGTCCGTGAATTTGAGCAGAGTGTACAAGGAGGCAGCCAGACTGCGAA GCATCGGCTGCTGCGGGTGGTTCAACGCCTCTTCCAGTACCAAGTGCTCCTC ACAGACTATTTAAACAACCTTTGTCCGGACTCCGCCGAGTACGACAACACA CAGGGTGCACTGAGCCTCATCTCCAAAGTCACAGACCGTGCCAACGACAGC ATGGAGCAAGGGGAAAACCTGCAGAAGCTGGTCCACATTGAGCACAGCGT CCGGGGCCAAGGGGATCTCCTCCAGCCAGGAAGGGAGTTTCTGAAGGAAG GGACGCTGATGAAAGTAACAGGGAAAAACAGACGGCCCCGGCACCTATTT CTGATGAACGATGTGCTCCTGTACACCTATCCCCAGAAGGATGGGAAGTAC CGGCTGAAGAACACATTGGCTGTGGCCAACATGAAGGTCAGCCGCCCTGTG ATGGAGAAAGTGCCCTACGCTCTAAAGATTGAGACTTCCGAGTCCTGCCTG ATGCTGTCTGCGAGCCCTCTTCGGAAACGTCGTAAAAGAAAGAAGAAAGA AGAAGAAATGGAAACTCTGGGTAAAGATATAACTCCTATCAATGAAGATAT TGAAGAGACAAATATTGCTTAA HHATL-> CAGCAGCTCTGCAGCACTCGGCTCTGCTCCACTCTGCTCAGCTCCGCTCCAG SEQ ID G B2 GAAGGCCACCTCCTCCTCCCCCTCCTCCTCCCGCTGTCACCACTCACCGCTC NO:74 ATAACCTCAAGGGGGTGGGGACCCCAGGGCTGGACACACCCCACCGTGGC CCCAGAGCTCAGCCGGTCGCACGGACGGACAGTTGGAAGCCGGACCCCAG AGCCTGAGGTGGGCAGTGTGCCAGGGTCCCTTGCGGCCTCCTCAAGGTTTT GAACGAAGAATGTGATCAGAACTGGTACAAGGCAGAGCTTAATGGAAAAG ACGGCTTCATTCCCAAGAACTACATAGAAATGAAACCACATCCGTGGTTTT TTGGCAAAATCCCCAGAGCCAAGGCAGAAGAAATGCTTAGCAAACAGCGG CACGATGGGGCCTTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTC TCCCTCTCTGTCAAGTTTGGAAACGATGTGCAGCACTTCAAGGTGCTCCGAG ATGGAGCCGGGAAGTACTTCCTCTGGGTGGTGAAGTTCAATTCTTTGAATG AGCTGGTGGATTATCACAGATCTACATCTGTCTCCAGAAACCAGCAGATAT TCCTGCGGGACATAGAACAGGTGCCACAGCAGCCGACATACGTCCAGGCCC TCTTTGACTTTGATCCCCAGGAGGATGGAGAGCTGGGCTTCCGCCGGGGAG ATTTTATCCATGTCATGGATAACTCAGACCCCAACTGGTGGAAAGGAGCTT GCCACGGGCAGACCGGCATGTTTCCCCGCAATTATGTCACCCCCGTGAACC GGAACGTCTAAGAGTCAAGAAGCAATTATTTAAAGAAAGTGAAAAATGTA AAACACATACAAAAGAATTAAACCCACAAGCTGCCTCTGACAGCAGCCTGT GAGGGAGTGCAGAACACCTGGCCGGGTCACCCTGTGACCCTCTCACTTTGG TTGGAACTTTAGGGGGTGGGAGGGGGCGTTGGATTTAAAAATGCCAAAACT TACCTATAAATTAAGAAGAGTTTTTATTACAAATTTTCACTGCTGCTCCTCT TTCCCCTCCTTTGTCTTTTTTTTCATCCTTTTTTCTCTTCTGTCCATCAGTGCA TGACGTTTAAGGCCACGTATAGTCCTAGCTGACGCCAATAATAAAAAACAA GAAACCAAGTGGGCTGGTATTCTCTCTATGCAAAATGTCTGTTTTAGTTGGA ATGACTGAAAGAAGAACAGCTGTTCCTGTGTTCTTCGTATATACACACAAA AAGGAGCGGGCAGGGCCGCTCGATGCCTTTGCTGTTTAGCTTCCTCCAGAG GAGGGGACTTGTAGGAATCTGCCTTCCAGCCCAGACCCCCAGTGTATTTTGT CCAAGTTCACAGTAGAGTAGGGTAGAAGGAAAGCATGTCTCTGCTTCCATG GCTTCCTGAGAAAGCCCACCTGGGCTGGGCGCGGTGGCTCACGCCTGTAAT CCCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACAAGGTCAGGAGTTCG AGACCAACCTAGCCAACATGGTGAAACCCCGTCTCTACTAAAAATAAGAAA TTAGCCGGGTGTGGCACGCACCTGTAGTCCCAGCTACTTGGGAGCCTGAGG CAGGAGAATCGCTTGAACCTGGGAAGTGGAGGTTGAGTGAGCCGGGACCG TGCCATTGTACTCCAGCCTGGGTGACAGAGCGAGATTCCGTCTCAAAAAAA AAAAAAAAAAGCCCACCTGAAAGCCTGTCTCTTTCCACTTTGTTGGCCCTTC CAGTGGGATTATCGAGCATGTTGTTTTTTCATAGTGCCTTTTTCCTTATTTCA AGGGTTGCTTCTGAGTGGTGTTTTTTTTTTTTTTTTAATTTGTTTTGTTTTAAA ATAAGTTAAAGGCAGTCCAGAGCTTTTCAGCCAATTTGTCTCCTACTCTGTG TAAATATTTTTCCCTCCGGGCAGGGGAGCCAGGGTAGAGCAAAGGAGACA AAGCAGGAGTGGAAGGTGAGGCGTTCTCCTGCTTGTACTAAGCCAGGAGGC TTTAAGCTCCAGCTTTAAGGGTTGTGAGCCCCTTGGGGGTTCAGGGAACTG CTTGCCCAGGGTGCAGTGTGAGTGTGATGGGCCACCGGGGCAAGAGGGAA GGTGACCGCCCAGCTCTCCCACATCCCACTGGATCTGGCTTACAGGGGGGT CGGAAGCCTGTCCTCACCGTCTCGGGGGTTGTGGCCCCCGCCCCCTCCCTAT ATGCACCCCTGGAACCAGCAAGTCCCAGACAAGGAGAGCGGAGGAGGAAG TCATGGGAACGCAGCCTCCAGTTGTAGCAGGTTTCACTATTCCTATGCTGGG GTACACAGTGAGAGTACTCACTTTTCACTTGTCTTGCTCTTAGATTGGGCCA TGGCTTTCATCCTGTGTCCCCTGACCTGTCCAGGTGAGTGTGAGGGCAGCAC TGGGAAGCTGGAGTGCTGCTTGTGCCTCCCTTCCCAGTGGGCTGTGTTGACT GCTGCTCCCCACCCCTACCGATGGTCCCAGGAAGCAGGGAGAGTTGGGGAA GGCAAGATTGGAAAGACAGGAAGACCAAGGCCTCGGCAGAACTCTCTGTC TTCTCTCCACTTCTGGTCCCCTGTGGTGATGTGCCTGTAATCTTTTTCTCCAC CCAAACCCCTTCCCACGACAAAAACAAGACTGCCTCCCTCTCTTCCGGGAG CTGGTGACAGCCTTGGGCCTTTCAGTCCCAAAGCGGCCGATGGGAGTCTCC CTCCGACTCCAGATATGAACAGGGCCCAGGCCTGGAGCGTTTGCTGTGCCA GGAGGCGGCAGCTCTTCTGGGCAGAGCCTGTCCCCGCCTTCCCTCACTCTTC CTCATCCTGCTTCTCTTTTCCTCGCAGATGATAAAAGGAATCTGGCATTCTA CACCTGGACCATTTGATTGTTTTATTTTGGAATTGGTGTATATCATGAAGCC TTGCTGAACTAAGTTTTGTGTGTATATATTTAAAAAAAAAATCAGTGTTTAA ATAAAGACCTATGTACTTAATCCTTTAACTCTGCGGATAGCATTTGGTAGGT AGTGATTAACTGTGAATAATAAATACACAATGAATTCTTCA GOPC-> ATGTCGGCGGGCGGTCCATGCCCAGCAGCAGCCGGAGGGGGCCCAGGGGG SEQ ID T MT11 CGCCTCCTGCTCCGTGGGGGCCCCTGGCGGGGTATCCATGTTCCGGTGGCTG NO:75 GAGGTGCTGGAGAAGGAGTTCGACAAAGCTTTTGTGGATGTGGATCTGCTC CTGGGAGAGATCGATCCAGACCAAGCGGACATCACTTATGAGGGGCGACA GAAGATGACCAGCCTGAGCTCCTGCTTTGCACAGCTTTGCCACAAAGCCCA GTCTGTGTCTCAAATCAACCACAAGCTGGAGAATCGGGACCAGTATTCACA TCTGCTAAGTGATCATTTTCTGCCATACCAAGGTCATAATTCCTTCCGTGAG AAATATTTTAGTGGGGTAACAAAAAGAATTGCCAAGGAAGAAAAATCCAC CCAGGAATGA ZDHHC2 CAGCGGCTCCCATCGCGGCTCCCGGGAGCTAAGCGAGACGGCGACGGCGG SEQ ID l-> CAGTCGTCCCTCCCCACGCGGGCGCGCGGGCATGCGGACACCCACTCGGCC NO:76 HMGB1 GGTCCAGGCCCTCAGGCTCCCGGAAGCGGAAGGGGAGAGCGGCCCGGCCT GGGCGGCGGCGCCGGAGGAGGCGGAGGTGGCGCGGCAGGAGGAGGGGAA AGAGCTGCTGGCGGTCGGGAGAGCGGCGGCAGCGAGAGGCGAGCCAGCGG CGACGAAAAATAACTAAACATGGGCAAAGGAGATCCTAAGAAGCCGAGAG GCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTCGGGAGGAGCATA AGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGT GCTCAGAGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAA GATATGGCAAAAGCGGACAAGGCCCGTTATGAAAGAGAAATGAAAACCTA TATCCCTCCCAAAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCAC CCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCTCTGAGTATCGCCCAAA AATCAAAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACT GGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGCAGCCTTATGAAA AGAAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGATATTGCTGCATAT CGAGCTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGA AAAAAGCAAGAAAAAGAAGGAAGAGGAGGAAGATGAGGAAGATGAAGAG GATGAGGAGGAGGAGGAAGATGAAGAAGATGAAGATGAAGAAGAAGATG ATGATGATGAATAAGTTGGTTCTAGCGCAGTTTTTTTTTTCTTGTCTATAAA GCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAAGAAAAAAATTGAA ATGTAAGGCTGTGTAAGATTTGTTTTTAAACTGTACAGTGTCTTTTTTTGTAT AGTTAACACACTACCGAATGTGTCTTTAGATAGCCCTGTCCTGGTGGTATTT TCAATAGCCACTAACCTTGCCTGGTACAGTATGGGGGTTGTAAATTGGCAT GGAAATTTAAAGCAGGTTCTTGTTGGTGCACAGCACAAATTAGTTATATAT GGGGATGGTAGTTTTTTCATCTTCAGTTGTCTCTGATGCAGCTTATACGAAA TAATTGTTGTTCTGTTAACTGAATACCACTCTGTAATTGCAAAAAAAAAAA AAAAGTTGCAGCTGTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACAAT TTTTTTTATTAGTATTGTTGTCCTTTTCATAGGTCTGAAATTTTTCTTCTTGAG GGGAAGCTAGTCTTTTGCTTTTGCCCATTTTGAATCACATGAATTATTACAG TGTTTATCCTTTCATATAGTTAGCTAATAAAAAGCTTTTGTCTACACACCCT GCATATCATAATGGGGGTAAAGTTAAGTTGAGATAGTTTTCATCCATAACT GAACATCCAAAATCTTGATCAGTTAAGAAATTTCACATAGCCCACTTACATT TACAAACTGAAGAGTAATCAATCTACTCAAAGCATGGGATTATTAGAATCA AACATTTTGAAAGTCTGTCCTTGAAGGACTAATAGAAAAGTATGTTCTAAC CTTTACATGAGGACTCTATTCTTTAACTCCCATTACCATGTAATGGCAGTTA TATTTTGCAGTTCCCACATTAAAGAAGACCTGAGAATGTATCCCCAAAAGC GTGAGCTTAAAATACAAGACTGCCATATTAAATTTTTTGTTGACATTAGTCT CAGTGAAGACTATGAAAATGCTGGCTATAGATGTCTTTTCCCATTTATCTAA ATATGGACTGCTCAGGAAACGAGACTTTCCATTACAAGTATTTTTAATTAAT TGGGCCAGCTTTTCAAACAAAGATGCCACATTCAAAATAGGGTATATTTTC CTATATTACGGTTTGCCCCTTTATAAATCCAAGTAGATAGGAAGAAAGAAG ACAAACTTTGCATCTCAGTATGAATTATTCAATTTATTTGAATGATTTTTCTT TACAAAACAAACTCATTCATTAGTCATGTTTATCTGCTTAGGAGTTTAGGGA ACAATTTGGCAATTTTGTGGTTTTCGAGATTATCGTTTTCTTAAAGTGCCAG TATTTTAAAATAGCGTTCTTGTAATTTTACACGCTTTTGTGATGGAGTGCTG TTTTGTTATATAATTTAGACTTGGATTCTTTCCATTTGCATTTGTTTATGTAA TTTCAGGAGGAATACTGAACATCTGAGTCCTGGATGATACTAATAAACTAA TAATTGCAGAGGTTTTAAATACTAGTTAAATGGCTTTCACTTAAGAACTTAA GATTTTGTTACATATTTTTAAATCTTGTTTCTAATAATACCTCTTAGCAGTAC CTTTTAAATAAGTATAAGGGATGGCAAAGTTTTTCCCTTTAAAAATACTCAC TTTATGCTTATAAATAGGTTAATGGGCTGATAAAAGGTTTTGTCAAACATTG CAAGTATTCGGTGCTATATATAAAGGAGGAAAAACTAGTTTTACTTTCAGA ATGATTTAAACAAGATTTTTAAAAACAAGATACATGCAAGCGAACAGCAGG GTTAGTGATAGGCTGCAATTGTGTCGAACATCAGATTTTTTGTTAAGAGGA GCAAATGACTCAATCTGATTTAGATGGAAGTTTCTACTGTATAGAAATCAC CATTAATCACCAACATTAATAATTCTGATCCATTTAAAATGAATTCTGGCTC AAGGAGAATTTGTAACTTTAGTAGGTACGTCATGACAACTACCATTTTTTTA AGATGTTGAGAATGGGAACAGTTTTTTTAGGGTTTATTCTTGACCACAGATC TTAAGAAAATGGACAAAACCCCTCTTCAATCTGAAGATTAGTATGGTTTGG TGTTCTAACAGTATCCCCTAGAAGTTGGATGTCTAAAACTCAAGTAAATGG AAGTGGGAGGCAATTTAGATAAGTGTAAAGCCTTGTAACTGAAGATGATTT TTTTTAGAAAGTGTATAGAAACTATTTTAATGCCAAGATAGTTACAGTGCTG TGGGGTTTAAAGACTTTGTTGACATCAAGAAAAGACTAAATCTATAATTAA TTGGGCCAACTTTTAAAATGAAGATGCTTTTTAAAACTAATGAACTAAGAT GTATAAATCTTAGTTTTTTTGTATTTTAAAGATAGGCATATGGCATATTGAT TAACGAGTCAAATTTCCTAACTTTGCTGTGCAAAGGTTGAGAGCTATTGCTG ATTAGTTACCACAGTTCTGATGATCGTCCCATCACAGTGTTGTTAATGTTTG CTGTATTTATTAATTTTCTTAAAGTGAAATCTGAAAAATGAAATTTGTGTGT CCTGTGTACCCGAGGGGTAATGATTAAATGATAAAGATAAGAA SUSD3-> ATGCGCTGGGCGGCCGCCACCCTCCGTGGCAAGGCGAGGCCCCGGGGGCG SEQ ID KIAA142 GGCCGGGGTCACCACGCCTGCCCCAGGGAACCGCACAGTTCTTTAAGGAAA NO:77 9 AACAGTAGTGCTCTGCATAGTTTACTGAAACGAGTGGTCAGCACATTTAGT AAGGACACAGGAGAGCTTGCATCTTCATTTTTAGAATTTATGAGACAAATT CTTAACTCTGACACAATTGGATGCTGTGGAGATGATAATGGTCTCATGGAA GTAGAGGGAGCTCATACATCACGGACGATGAGTATTAATGCTGCAGAGTTA AAACAGCTTCTACAAAGCAAAGAAGAAAGTCCAGAAAATTTGTTCCTTGAA CTAGAGAAGCTTGTTTTGGAACATTCAAAAGATGATGACAATCTGGATTCT TTGTTGGACAGTGTAGTTGGACTTAAGCAGATGCTGGAGTCATCAGGTGAC CCTTTACCTCTCAGTGACCAGGATGTAGAACCAGTACTTTCAGCTCCAGAAT CTCTTCAGAATCTGTTTAACAATAGGACTGCCTATGTGCTTGCTGATGTCAT GGATGATCAGTTGAAATCTATGTGGTTCACTCCATTTCAGGCTGAAGAGAT AGATACAGATCTGGATTTGGTAAAGGTTGACTTAATTGAACTCTCTGAAAA ATGCTGTAGTGACTTTGATTTGCACTCAGAATTAGAGCGCTCATTTTTGTCA GAACCATCATCTCCAGGAAGAACCAAGACTACTAAAGGATTCAAACTTGGG AAGCACAAGCATGAGACCTTTATAACGTCAAGTGGAAAATCTGAATACATT GAACCTGCCAAAAGAGCTCATGTTGTGCCACCACCAAGAGGAAGGGGCAG GGGAGGATTTGGACAGGGTATACGACCTCATGATATTTTTCGTCAGAGAAA ACAGAACACAAGTAGACCACCATCTATGCATGTGGATGACTTTGTTGCTGC TGAAAGTAAAGAAGTGGTTCCTCAAGATGGAATACCTCCACCAAAACGGCC ACTCAAAGTATCACAGAAGATTTCTTCCCGTGGTGGGTTTTCAGGCAATAG AGGAGGACGGGGTGCTTTCCACAGTCAGAATAGGTTTTTCACACCACCTGC TTCAAAAGGAAACTACAGTCGTCGGGAAGGAACAAGAGGCTCCAGTTGGA GTGCTCAGAATACTCCTCGAGGAAATTACAATGAAAGTCGTGGAGGCCAGA GCAATTTTAACAGAGGCCCTCTTCCACCATTACGACCCCTTAGTTCTACAGG TTACCGCCCAAGTCCTCGGGACCGTGCTTCTAGAGGTCGTGGGGGACTTGG ACCTTCCTGGGCTAGTGCAAATAGCGGCAGTGGAGGCTCAAGAGGAAAGTT TGTTAGTGGAGGCAGTGGTAGAGGTCGTCATGTACGCTCCTTTACACGATA A GBAS-> ATGGCGGCGCGAGTGCTGCGCGCCCGCGGAGCGGCCTGGGCCGGCGGCCT SEQ ID PCLO CCTGCAGCGGGCGGCCCCCTGCAGCCTCCTGCCCAGGCTCCGATTCAAGAA NO:78 TGGCTTTGTTTAAATTGCCAAACCCAGAGAGCAATATCAGGACAGCTTGGA GACATACGCAAAATGCCACCTGCACCATCAGGACCCAAAGCATCTCCTATG CCTGTTCCTACAGAATCATCATCTCAGAAAACAGCAGTGCCTCCCCAAGTA AAATTAGTGAAAAAGCAAGAACAAGAAGTAAAAACGGAAGCTGAAAAAGT CATTCTGGAAAAAGTAAAGGAAACACTATCAATGGAAAAAATTCCTCCTAT GGTAACCACAGATCAAAAACAAGAAGAGAGTAAACTAGAGAAAGACAAA GCTTCAGCTCTTCAAGAAAAAAAGCCACTCCCTGAAGAAAAAAAACTAATC CCTGAAGAAGAAAAGATACGTTCTGAAGAAAAAAAGCCACTCCTAGAAGA AAAAAAGCCAACCCCTGAAGACAAAAAGCTACTCCCAGAGGCAAAAACAT CAGCCCCAGAAGAACAGAAACATGACTTACTTAAATCTCAAGTACAAATTG CTGAAGAAAAGCTTGAAGGCAGAGTGGCTCCAAAGACAGTGCAAGAAGGG AAACAACCACAGACCAAGATGGAAGGTTTACCATCTGGCACACCTCAGAGT TTACCTAAAGAAGATGATAAGACAACCAAAACAATAAAAGAACAGCCACA GCCACCATGCACAGCAAAACCTGATCAGGTGGAACCTGGGAAAGAAAAAA CAGAAAAGGAAGATGACAAATCAGACACCTCAAGTTCTCAGCAGCCTAAA AGCCCCCAAGGTCTGAGCGACACGGGATATTCTTCCGATGGAATATCAAGC TCACTTGGTGAAATTCCAAGTCTTATTCCAACTGATGAAAAGGATATTCTCA AGGGACTCAAAAAGGACTCTTTTTCACAAGAAAGCAGCCCTTCCAGCCCCT CAGATTTGGCTAAGTTAGAAAGTACAGTCCTATCTATTTTGGAAGCTCAAG CAAGTACACTTGCTGATGAAAAGTCAGAAAAGAAAACACAACCCCATGAA GTTTCTCCTGAACAGCCTAAAGACCAAGAGAAAACTCAGAGTTTATCTGAA ACCTTGGAAATTACTATTTCAGAAGAGGAGATCAAAGAGAGTCAAGAAGA AAGGAAAGACACTTTTAAAAAAGATAGCCAACAAGATATTCCTTCCAGCAA GGACCATAAAGAGAAGTCTGAGTTTGTTGATGACATAACTACTAGAAGAGA GCCTTATGATTCAGTTGAAGAGAGTAGTGAAAGTGAAAACTCACCTGTTCC ACAAAGAAAACGAAGAACTAGTGTTGGCTCATCAAGCAGTGATGAGTATA AACAGGAAGACAGCCAAGGATCAGGGGAAGAGGAGGACTTCATTCGAAAA CAAATCATAGAAATGAGTGCTGATGAAGATGCTTCAGGTTCTGAAGATGAT GAGTTCATCAGAAACCAGCTCAAAGAGATTAGTAGCAGTACTGAGAGCCA GAAGAAGGAAGAAACAAAGGGAAAAGGCAAAATAACAGCAGGGAAACAC AGACGACTGACTCGAAAAAGTAGCACAAGCATTGATGAAGATGCAGGAAG ACGTCACTCATGGCATGATGAAGACGATGAAGCATTTGATGAAAGTCCTGA ACTTAAATACAGAGAAACTAAAAGTCAGGAAAGTGAAGAACTTGTAGTTA CTGGAGGAGGAGGGCTACGCCGATTTAAAACAATTGAGCTCAACAGTACA ATAGCAGATAAATATTCTGCAGAGTCATCACAGAAAAAAACAAGTTTGTAT TTTGACGAAGAGCCAGAATTGGAAATGGAAAGCCTGACAGACTCACCTGA AGATAGGTCAAGGGGAGAGGGATCTTCGAGTCTGCATGCTTCCAGCTTCAC TCCTGGTACATCCCCTACATCAGTATCATCACTTGATGAGGACAGTGACAGT AGCCCGAGTCACAAAAAAGGAGAGAGCAAACAGCAACGCAAAGCTCGGCA CAGACCACATGGCCCTCTTTTGCCTACTATTGAAGATTCTTCAGAGGAAGA AGAATTGAGAGAGGAAGAAGAATTATTAAAGGAGCAAGAAAAGCAGAGG GAAATAGAACAGCAACAAAGAAAGAGTTCTAGTAAAAAATCAAAGAAAGA CAAAGATGAACTTCGAGCTCAGAGAAGAAGGGAAAGGCCAAAGACACCAC CTAGTAATCTCTCTCCCATTGAAGATGCATCTCCGACAGAAGAGTTACGTCA GGCTGCAGAAATGGAGGAGCTCCATAGATCTTCTTGTTCTGAATATTCACCT AGCATAGAGTCAGACCCAGAAGGTTTTGAAATAAGCCCGGAAAAAATAAT AGAAGTACAAAAAGTTTATAAATTGCCCACAGCTGTTTCATTATACTCACC AACAGATGAGCAATCTATTATGCAGAAAGAAGGTAGCCAAAAGGCGTTAA AAAGTGCTGAGGAGATGTATGAAGAAATGATGCATAAAACACACAAATAC AAAGCTTTTCCAGCTGCAAATGAACGAGATGAAGTGTTTGAAAAAGAGCCT TTGTATGGTGGGATGCTAATAGAGGATTATATTTATGAATCTTTAGTAGAAG ACACGTACAATGGATCGGTAGATGGCAGTCTGCTAACAAGGCAAGAAGAA GAAAATGGATTTATGCAGCAGAAAGGAAGAGAGCAAAAGATAAGACTTTC AGAACAGATTTATGAAGATCCTATGCAGAAAATTACAGACCTCCAGAAAGA GTTTTATGAGTTAGAAAGCTTACATTCTGTTGTGCCTCAGGAAGATATTGTT TCAAGCTCTTTTATCATCCCAGAAAGCCATGAGATAGTGGACCTGGGTACT ATGGTAACTTCTACAGAAGAAGAAAGGAAACTACTAGATGCTGATGCTGCC TATGAAGAACTTATGAAGAGGCAACAGATGCAATTAACACCTGGATCTAGC CCAACCCAGGCCCCCATTGGTGAGGATATGACAGAGTCCACCATGGACTTT GACAGAATGCCAGATGCCTCTTTGACATCAAGTGTTCTCTCAGGAGCGTCTC TTACAGATTCGACCAGCAGTGCAACACTCTCTATCCCAGATGTTAAAATAA CCCAACATTTTTCAACAGAAGAAATTGAGGATGAATATGTAACCGATTATA CAAGAGAAATTCAAGAGATAATTGCCCATGAATCGCTGATTTTGACCTACT CGGAGCCTTCAGAAAGTGCTACATCTGTCCCACCCTCTGACACACCTTCTCT CACATCATCTGTTTCTTCGGTCTGTACCACAGATAGCTCTTCACCCATTACT ACCCTGGATAGCATAACCACAGTTTATACAGAGCCAGTGGACATGATAACT AAATTTGAAGATTCTGAGGAAATTTCTTCATCAACTTATTTTCCAGGCAGCA TTATAGACTATCCAGAAGAAATAAGTGTATCTTTAGATCGGACTGCCCCAC CAGATGGTAGAGCTAGTGCTGATCATATTGTTATTTCCTTATCTGATATGGC ATCTTCTATCATAGAATCTGTAGTACCTAAACCTGAAGGGCCAGTTGCTGAC ACTGTTTCTACTGACTTACTTATATCTGAAAAGGACCCAGTGAAGAAAGCC AAGAAGGAAACTGGGAATGGAATCATTCTGGAAGTTTTGGAAGCTTACAGA GATAAAAAGGAGTTGGAGGCCGAACGAACAAAAAGTAGCTTATCCGAAAC CGTGTTTGATCACCCACCTTCTTCTGTAATAGCCCTTCCAATGAAAGAGCAG CTTTCAACTACATACTTTACATCTGGAGAGACCTTTGGTCAGGAAAAACCTG CATCTCAGTTACCATCTGGCAGTCCTTCTGTTTCCTCTCTTCCAGCTAAACCT CGCCCATTCTTTAGAAGTTCTTCTTTGGATATATCAGCTCAACCTCCTCCCCC TCCTCCCCCTCCCCCTCCTCCTCCTCCTCCACCACCACCCCCTCCTCCCCCAC CACTTCCTCCACCAACTTCACCTAAACCAACTATTCTTCCTAAAAAAAAGTT AACAGTTGCATCTCCAGTGACTACAGCTACACCTCTGTTTGATGCTGTTACT ACTCTAGAGACCACAGCTGTTCTGAGAAGTAATGGATTACCTGTTACAAGA ATATGTACTACTGCACCTCCTCCTGTTCCTCCTAAGCCATCTTCAATTCCATC TGGACTTGTATTTACCCACAGGCCTGAGCCAAGCAAACCTCCAATCGCCCC CAAACCAGTGATTCCTCAGCTTCCAACAACTACACAAAAACCAACAGATAT ACACCCCAAACCAACAGGCCTATCTTTAACTTCAAGTATGACCTTAAATTTA GTGACTTCAGCAGATTATAAATTGCCTTCCCCTACCTCCCCACTTTCCCCAC ACTCCAACAAGTCTTCACCAAGATTTTCCAAATCCCTCACAGAAACTTATGT AGTTATTACATTGCCATCTGAACCAGGGACTCCAACAGATTCTTCTGCTAGT CAAGCAATTACCAGTTGGCCCTTGGGATCACCCTCCAAAGATCTGGTTTCTG TTGAACCTGTGTTTTCTGTAGTTCCTCCTGTGACAGCTGTAGAAATTCCAAT TTCTTCAGAACAGACCTTCTACATCTCTGGAGCTTTACAGACATTTTCTGCT ACCCCTGTCACAGCACCCTCTTCATTTCAAGCAGCTCCCACATCAGTTACAC AGTTTCTCACTACTGAAGTTTCCAAGACTGAGGTTTCAGCAACCAGAAGTA CAGCTCCTAGTGTTGGTCTCAGCAGCATTTCCATAACAATTCCTCCAGAGCC TCTTGCTCTAGATAACATACATTTAGAGAAGCCTCAGTATAAAGAAGATGG AAAATTGCAACTTGTTGGTGATGTAATTGATTTGCGTACAGTACCAAAGGT AGAAGTTAAAACAACTGATAAATGTATTGATCTTTCTGCTTCTACAATGGAT GTGAAAAGGCAGATCACAGCAAATGAAGTTTATGGGAAACAAATTAGTGC TGTCCAACCCTCTATTATAAATCTTAGTGTGACATCATCAATAGTGACTCCT GTATCTCTGGCCACTGAGACAGTGACCTTTGTCACATGCACAGCTAGTGCA AGTTACACTACAGGCACAGAAAGCCTAGTGGGTGCAGAACATGCAATGAC AACACCACTCCAACTTACAACATCAAAGCATGCTGAGCCCCCATACAGGAT ACCAAGTGACCAGGTCTTTCCTATAGCTAGGGAAGAAGCACCAATAAACTT ATCTCTAGGTACTCCAGCACATGCAGTGACATTGGCTATTACAAAACCTGTC ACTGTGCCTCCTGTTGGTGTCACAAATGGATGGACTGATAGCACCGTATCCC AGGGAATCACTGATGGGGAAGTAGTGGATCTCAGTACAACCAAGTCTCACA GAACAGTCGTAACAATGGATGAGTCTACTTCAAGTGTGATGACCAAAATAA TAGAAGATGAAAAACCCGTTGATTTAACCGCAGGGAGAAGAGCTGTGTGCT GTGATGTGGTTTATAAATTACCATTTGGAAGGAGCTGCACAGCACAGCAGC CTGCAACTACTCTTCCTGAGGATCGTTTTGGTTATAGGGATGACCACTATCA GTATGATCGATCAGGGCCATATGGTTATAGAGGGATTGGGGGAATGAAGCC TTCCATGTCTGACACAAATTTAGCAGAAGCTGGACATTTTTTCTATAAAAGT AAGAATGCTTTTGATTATTCTGAAGGAACTGACACAGCAGTAGATCTGACT TCAGGGAGAGTTACTACAGGTGAGGTAATGGATTATTCAAGCAAGACTACA GGTCCATATCCAGAAACACGACAAGTCATTTCAGGAGCTGGGATTAGTACC CCACAGTATTCCACAGCAAGAATGACACCACCACCAGGACCCCAGTATTGT GTGGGGAGTGTTTTGAGGTCATCTAATGGTGTTGTCTATTCTTCAGTAGCAA CTCCAACACCCTCTACATTTGCTATCACCACACAACCTGGCTCCATTTTCAG CACCACAGTGAGGGATTTGTCTGGTATTCATACGGCTGATGCAGTGACTTC ATTACCTGCCATGCACCATAGCCAGCCAATGCCTAGATCATATTTTATAACA ACAGGTGCATCTGAAACGGACATTGCAGTAACTGGTATTGATATCAGTGCC AGTTTGCAAACTATTACTATGGAGTCTCTTACTGCTGAGACGATAGACTCTG TTCCCACTTTAACCACAGCATCCGAAGTGTTTCCTGAAGTGGTGGGAGATG AAAGTGCTCTTTTAATTGTCCCTGAAGAAGATAAACAACAGCAGCAGCTAG ACTTGGAGCGTGAGCTCCTGGAACTGGAGAAAATTAAGCAACAGCGCTTTG CTGAGGAATTGGAGTGGGAACGTCAGGAAATTCAAAGGTTCCGAGAACAA GAAAAGATCATGGTTCAGAAAAAGTTGGAGGAGCTGCAGTCTATGAAGCA ACACCTTCTCTTTCAGCAAGAAGAAGAGCGGCAAGCCCAGTTCATGATGAG GCAGGAGACGTTAGCTCAGCAACAGTTACAGCTTGAGCAGATCCAACAGCT GCAACAACAGCTTCACCAGCAGCTGGAGGAGCAAAAGATTCGGCAGATCT ACCAGTATAACTATGACCCTTCTGGAACTGCTTCTCCACAAACCACTACAG AGCAGGCAATTTTGGAAGGTCAGTATGCTGCTCTGGAAGGCAGTCAATTTT GGGCAACTGAAGATGCAACCACCACAGCTTCAGCTGTTGTGGCAATTGAAA TACCACAAAGCCAAGGATGGTACACCGTTCAGTCTGATGGTGTTACTCAGT ACATTGCCCCACCTGGTATCCTGAGCACTGTTTCAGAAATACCTCTAACAGA TGTTGTTGTGAAAGAGGAAAAACAACCCAAAAAGAGAAGTTCTGGAGCTA AAGTCCGAGGACAGTATGATGACATGGGAGAAAATATGACAGATGATCCC CGAAGTTTTAAAAAGATAGTGGACAGTGGTGTACAAACGGATGACGAAGA TGCCACAGATCGGAGCTATGTGAGTAGGAGAAGGAGAACTAAAAAGAGTG TGGATACAAGCGTCCAAACTGATGATGAAGATCAGGATGAGTGGGATATGC CTACTAGATCAAGGAGGAAAGCTCGTGTAGGGAAATATGGTGACAGCATG ACAGAGGCTGACAAGACCAAACCCCTTTCCAAAGTCTCCAGCATAGCAGTT CAAACGGTAGCAGAGATATCTGTGCAAACTGAACCAGTTGGAACCATAAG AACACCCTCCATACGGGCACGAGTGGATGCCAAGGTAGAAATAATTAAAC ACATTTCAGCACCTGAAAAGACTTACAAAGGGGGCAGTTTAGGATGTCAAA CAGAAGCAGATTCAGACACACAAAGTCCTCAATATCTGAGTGCCACATCTC CACCCAAAGACAAGAAACGCCCAACACCTTTAGAGATTGGTTATTCATCTC ACCTCCGGGCAGATTCCACAGTACAGCTGGCTCCTTCCCCACCCAAATCCC CCAAAGTCCTTTACTCACCCATCTCACCACTTTCACCAGGCAAAGCCTTAGA ATCAGCCTTTGTACCTTATGAAAAACCCCTCCCTGATGATATAAGTCCACAG AAAGTACTGCATCCAGATATGGCTAAAGTTCCCCCAGCAAGTCCTAAGACA GCCAAGATGATGCAGCGTTCTATGTCTGACCCCAAGCCTCTGAGTCCAACA GCAGACGAAAGTTCCAGGGCTCCTTTTCAGTATACCGAGGGCTATACGACT AAAGGTTCTCAAACCATGACATCCTCTGGAGCCCAGAAAAAAGTTAAAAGA ACTCTGCCAAATCCACCTCCTGAGGAGATTTCCACAGGAACTCAATCCACA TTCAGCACAATGGGCACAGTTTCCAGGAGAAGGATCTGCAGAACCAACACA ATGGCACGAGCCAAGATTCTCCAGGACATAGACAGAGAGCTTGATCTTGTG GAAAGGGAGTCTGCAAAACTTCGAAAGAAACAAGCAGAGCTTGATGAAGA AGAAAAGGAGATTGATGCTAAGCTACGATACCTGGAAATGGGAATTAACA GGAGGAAAGAGGCCCTATTAAAGGAGAGAGAAAAGAGAGAACGAGCCTA CCTCCAGGGAGTAGCTGAGGATCGTGATTACATGTCTGACAGTGAAGTGAG TAGCACAAGACCAACCCGAATAGAAAGTCAGCATGGCATTGAGCGACCAA GAACTGCTCCCCAAACTGAATTCAGCCAGTTTATACCACCACAAACCCAAA CAGAATCTCAACTAGTTCCTCCGACAAGTCCTTACACACAATACCAGTACTC TTCCCCTGCTCTTCCTACCCAAGCACCCACCTCATACACTCAACAGTCTCAT TTTGAGCAACAAACTTTGTACCATCAGCAAGTTTCACCTTATCAGACTCAGC CAACATTCCAAGCTGTGGCAACAATGTCCTTCACACCTCAAGTTCAACCTAC ACCAACCCCACAGCCTTCTTATCAGTTACCTTCACAGATGATGGTGATACAA CAGAAGCCACGGCAAACTACATTATATTTGGAGCCCAAGATAACCTCAAAC TATGAAGTGATTCGCAACCAACCCCTTATGATAGCACCTGTTTCTACGGATA ACACATTTGCTGTTTCCCATCTTGGTAGTAAGTACAATAGTTTAGACTTGAG AATAGGTTTGGAGGAAAGAAGTAGCATGGCAAGCAGTCCAATATCAAGCA TATCTGCAGATTCTTTCTATGCAGATATTGATCACCATACTCCACGAAATTA TGTCCTAATTGACGACATTGGAGAGATCACCAAAGGAACAGCGGCATTAAG CACCGCATTTAGCCTTCATGAAAAGGATCTGTCAAAAACAGACCGTCTCCT TCGAACCACTGAGACACGCCGGTCTCAAGAAGTGACAGATTTCCTAGCACC TTTACAGTCTTCCTCTAGATTGCATAGTTATGTGAAGGCGGAGGAAGACCC AATGGAGGATCCTTACGAGTTAAAGCTTCTGAAACATCAGATTAAACAGGA ATTTCGTAGAGGGACAGAGAGCTTAGATCACCTTGCTGGTCTTTCTCATTAT TACCATGCTGATACTAGCTACAGACATTTTCCAAAATCTGAGAAGTATAGC ATCAGTAGACTCACACTTGAAAAACAAGCAGCAAAACAACTGCCAGCAGC CATACTTTATCAAAAGCAGTCAAAGCATAAGAAATCACTAATTGACCCTAA AATGTCAAAATTTTCACCTATTCAAGAAAGTAGAGACCTTGAACCTGATTA TTCAAGCTATATGACTTCTAGCACTTCATCTATTGGTGGCATTTCCTCCAGG GCAAGGCTCCTTCAAGATGACATCACTTTTGGCCTCAGAAAAAATATTACA GACCAACAAAAATTTATGGGATCTTCTCTTGGCACAGGACTGGGCACATTA GGAAATACCATACGCTCAGCTCTGCAGGATGAAGCGGATAAGCCATACAGT AGTGGCAGCAGGTCCAGACCTTCCTCCAGACCTTCCTCTGTCTATGGGCTTG ATTTATCAATTAAAAGGGATTCTTCTAGCTCTTCCCTAAGACTGAAAGCTCA AGAGGCTGAAGCTCTAGATGTTTCCTTTAGTCATGCATCATCCTCTGCCAGA ACTAAGCCGACCAGTTTGCCAATTAGTCAAAGTAGAGGAAGAATACCAATT GTGGCCCAGAATTCTGAAGAAGAAAGCCCACTCAGTCCTGTTGGCCAGCCA ATGGGAATGGCCAGGGCTGCAGCTGGACCCCTGCCACCAATATCTGCAGAC ACCAGGGATCAGTTTGGATCAAGCCACTCATTGCCTGAAGTTCAGCAACAC ATGAGGGAAGAATCACGGACTCGAGGCTATGACCGTGACATAGCATTCATC ATGGATGACTTCCAACATGCCATGTCAGACAGTGAAGCCTATCATCTGCGT CGTGAGGAAACAGATTGGTTTGATAAACCCAGGGAGTCTCGTTTGGAAAAT GGACATGGTCTGGACCGAAAACTGCCGGAAAGATTGGTCCACTCTAGACCA CTCAGTCAACATCAAGAGCAAATTATACAGATGAACGGGAAAACTATGCAC TACATCTTTCCTCACGCAAGGATAAAAATAACAAGAGACTCAAAGGATCAC ACAGTTTCAGGTAATGGATTAGGAATTAGAATTGTGGGTGGTAAAGAAATC CCGGGACATAGTGGAGAAATTGGAGCCTATATTGCCAAGATTCTTCCTGGG GGAAGTGCGGAACAGACGGGGAAGCTTATGGAAGGGATGCAAGTATTGGA ATGGAATGGAATTCCCTTGACTTCTAAAACATATGAAGAAGTTCAGAGTAT CATTAGTCAGCAAAGTGGGGAAGCAGAAATATGTGTAAGACTGGACCTCA ATATGCTATCAGATTCTGAAAATTCCCAGCATCTGGAACTTCATGAGCCACC AAAAGCTGTGGATAAGGCGAAATCCCCAGGGGTTGATCCTAAGCAGTTGGC AGCAGAACTCCAGAAGGTTTCACTACAGCAGTCACCGCTGGTTCTGTCATC AGTTGTTGAAAAAGGATCTCATGTTCATTCAGGTCCTACATCAGCAGGATC CAGTTCCGTTCCCAGCCCTGGGCAACCAGGGTCCCCCTCAGTGAGCAAAAA GAAGCACGGCAGCAGCAAGCCTACCGATGGAACAAAGGTTGTCTCTCATCC AATTACAGGAGAAATTCAGCTTCAAATTAACTATGATCTTGGAAATCTCAT AATACATATTCTCCAAGCAAGAAATCTTGTTCCTCGAGACAACAATGGTTA TTCTGACCCTTTTGTGAAAGTGTACCTTCTTCCAGGGAGAGGTCAAGTCATG GTTGTCCAGAATGCAAGTGCTGAGTACAAGAGAAGGACTAAACATGTCCAG AAAAGTCTTAATCCTGAGTGGAATCAAACAGTAATTTATAAAAGTATTTCC ATGGAACAGCTCAAGAAGAAAACACTGGAGGTGACAGTTTGGGATTATGA TAGATTTTCATCCAACGACTTCCTTGGGGAGGTATTGATTGATTTATCTAGC ACATCTCACCTCGATAACACTCCAAGGTGGTATCCTCTCAAAGAACAGACT GAAAGCATTGATCATGGCAAGTCTCATTCCAGTCAGAGCAGCCAGCAGTCC CCAAAGCCATCTGTTATCAAAAGCAGAAGCCATGGTATCTTCCCTGACCCA TCAAAGGACATGCAGGTTCCCACCATTGAGAAATCCCATAGTAGTCCTGGT AGCTCAAAATCATCATCAGAAGGCCATCTCCGTTCTCATGGACCATCTCGC AGTCAAAGCAAAACCAGCGTCACTCAGACCCACCTGGAAGATGCAGGGGC TGCCATAGCTGCTGCCGAAGCTGCCGTGCAACAACTCCGCATTCAACCAAG TAAAAGACGCAAATAA SNX9-> ATGGCCACCAAGGCATTTATTAATACAGCAAAAGAAATTTATGAAAAAATT SEQ ID AB2A CAAGAAGGAGTCTTTGACATTAATAATGAGGCAAATGGCATTAAAATTGGC NO:79 CCTCAGCATGCTGCTACCAATGCAACACATGCAGGCAATCAGGGAGGACAG CAGGCTGGGGGCGGCTGCTGTTGA DNMBP- CAGGGGCGGAGGTGACAGCGGGCTGGGGACTGGCGGCTGCAACTGCCTGC SEQ ID > CGCGCCGAGGGACCGCCGGGCGGCGGAAAGCAGGAGTTCCGATTCTGAAG NO:80 TACC2 AGGCATTTGAGACCCCGGAGTCAACGACCCCTGTCAAAGCTCCGCCAGCTC CACCCCCACCACCCCCCGAAGTCATCCCAGAACCCGAGGTCAGCACACAGC CACCCCCGGAAGAACCAGGATGTGGTTCTGAGACAGTCCCTGTCCCTGATG GCCCACGGAGCGACTCGGTGGAAGGAAGTCCCTTCCGTCCCCCGTCACACT CCTTCTCTGCCGTCTTCGATGAAGACAAGCCGATAGCCAGCAGTGGGACTT ACAACTTGGACTTTGACAACATTGAGCTTGTGGATACCTTTCAGACCTTGGA GCCTCGTGCCTCAGACGCTAAGAATCAGGAGGGCAAAGTGAACACACGGA GGAAGTCCACGGATTCCGTCCCCATCTCTAAGTCTACACTGTCCCGGTCGCT CAGCCTGCAAGCCAGTGACTTTGATGGTGCTTCTTCCTCAGGCAATCCCGAG GCCGTGGCCCTTGCCCCAGATGCATATAGCACGGGTTCCAGCAGTGCTTCT AGTACCCTTAAGCGAACTAAAAAACCGAGGCCGCCTTCCTTAAAAAAGAAA CAGACCACCAAGAAACCCACAGAGACCCCCCCAGTGAAGGAGACGCAACA GGAGCCAGATGAAGAGAGCCTTGTCCCCAGTGGGGAGAATCTAGCATCTGA GACGAAAACGGAATCTGCCAAGACGGAAGGTCCTAGCCCAGCCTTATTGGA GGAGACGCCCCTTGAGCCCGCTGTGGGGCCCAAAGCTGCCTGCCCTCTGGA CTCAGAGAGTGCAGAAGGGGTTGTCCCCCCGGCTTCTGGAGGTGGCAGAGT GCAGAACTCACCCCCTGTCGGGAGGAAAACGCTGCCTCTTACCACGGCCCC GGAGGCAGGGGAGGTAACCCCATCGGATAGCGGGGGGCAAGAGGACTCTC CAGCCAAAGGGCTCTCCGTAAGGCTGGAGTTTGACTATTCTGAGGACAAGA GTAGTTGGGACAACCAGCAGGAAAACCCCCCTCCTACCAAAAAGATAGGC AAAAAGCCAGTTGCCAAAATGCCCCTGAGGAGGCCAAAGATGAAAAAGAC ACCCGAGAAACTTGACAACACTCCTGCCTCACCTCCCAGATCCCCTGCTGA ACCCAATGACATCCCCATTGCTAAAGGTACTTACACCTTTGATATTGACAAG TGGGATGACCCCAATTTTAACCCTTTTTCTTCCACCTCAAAAATGCAGGAGT CTCCCAAACTGCCCCAACAATCATACAACTTTGACCCAGACACCTGTGATG AGTCCGTTGACCCCTTTAAGACATCCTCTAAGACCCCCAGCTCACCTTCTAA ATCCCCAGCCTCCTTTGAGATCCCAGCCAGTGCTATGGAAGCCAATGGAGT GGACGGGGATGGGCTAAACAAGCCCGCCAAGAAGAAGAAGACGCCCCTAA AGACTGACACATTTAGGGTGAAAAAGTCGCCAAAACGGTCTCCTCTCTCTG ATCCACCTTCCCAGGACCCCACCCCAGCTGCTACACCAGAAACACCACCAG TGATCTCTGCGGTGGTCCACGCCACAGATGAGGAAAAGCTGGCGGTCACCA ACCAGAAGTGGACGTGCATGACAGTGGACCTAGAGGCTGACAAACAGGAC TACCCGCAGCCCTCGGACCTGTCCACCTTTGTAAACGAGACCAAATTCAGTT CACCCACTGAGGAGTTGGATTACAGAAACTCCTATGAAATTGAATATATGG AGAAAATTGGCTCCTCCTTACCTCAGGACGACGATGCCCCGAAGAAGCAGG CCTTGTACCTTATGTTTGACACTTCTCAGGAGAGCCCTGTCAAGTCATCTCC CGTCCGCATGTCAGAGTCCCCGACGCCGTGTTCAGGGTCAAGTTTTGAAGA GACTGAAGCCCTTGTGAACACTGCTGCGAAAAACCAGCATCCTGTCCCACG AGGACTGGCCCCTAACCAAGAGTCACACTTGCAGGTGCCAGAGAAATCCTC CCAGAAGGAGCTGGAGGCCATGGGCTTGGGCACCCCTTCAGAAGCGATTGA AATTACAGCTCCCGAGGGCTCCTTTGCCTCTGCTGACGCCCTCCTCAGCAGG CTAGCTCACCCCGTCTCTCTCTGTGGTGCACTTGACTATCTGGAGCCCGACT TAGCAGAAAAGAACCCCCCACTATTCGCTCAGAAACTCCAGGAGGAGTTAG AGTTTGCCATCATGCGGATAGAAGCCCTGAAGCTGGCCAGGCAGATTGCTT TGGCTTCCCGCAGCCACCAGGATGCCAAGAGAGAGGCTGCTCACCCAACAG ACGTCTCCATCTCCAAAACAGCCTTGTACTCCCGCATCGGGACCGCTGAGG TGGAGAAACCTGCAGGCCTTCTGTTCCAGCAGCCCGACCTGGACTCTGCCC TCCAGATCGCCAGAGCAGAGATCATAACCAAGGAGAGAGAGGTCTCAGAA TGGAAAGATAAATATGAAGAAAGCAGGCGGGAAGTGATGGAAATGAGGAA AATAGTGGCCGAGTATGAGAAGACCATCGCTCAGATGATAGAGGACGAAC AGAGAGAGAAGTCAGTCTCCCACCAGACGGTGCAGCAGCTGGTTCTGGAG AAGGAGCAAGCCCTGGCCGACCTGAACTCCGTGGAGAAGTCTCTGGCCGAC CTCTTCAGAAGATATGAGAAGATGAAGGAGGTCCTAGAAGGCTTCCGCAAG AATGAAGAGGTGTTGAAGAGATGTGCGCAGGAGTACCTGTCCCGGGTGAA GAAGGAGGAGCAGAGGTACCAGGCCCTGAAGGTGCACGCGGAGGAGAAAC TGGACAGGGCCAATGCTGAGATTGCTCAGGTTCGAGGCAAGGCCCAGCAG GAGCAAGCCGCCCACCAGGCCAGCCTGCGGAAGGAGCAGCTGCGAGTGGA CGCCCTGGAAAGGACGCTGGAGCAGAAGAATAAAGAAATAGAAGAACTCA CCAAGATTTGTGACGAACTGATTGCCAAAATGGGGAAAAGCTAACTCTGAA CCGAATGTTTTGGACTTAACTGTTGCGTGCAATATGACCGTCGGCACACTGC TGTTCCTCCAGTTCCATGGACAGGTTCTGTTTTCACTTTTTCGTATGCACTAC TGTATTTCCTTTCTAAATAAAATTGATTTGATTGTATGCAGTACTAAGGAGA CTATCAGAATTTCTTGCTATTGGTTTGCATTTTCCTAGTATAATTCATAGCAA GTTGACCTCAGAGTTCCTGTATCAGGGAGATTGTCTGATTCTCTAATAAAAG ACACATTGCTGACCTTGGCCTTGCCCTTTGTACACAAGTTCCCAGGGTGAGC AGCTTTTGGATTTAATATGAACATGTACAGCGTGCATAGGGACTCTTGCCTT AAGGAGTGTAAACTTGATCTGCATTTGCTGATTTGTTTTTAAAAAAACAAG AAATGCATGTTTCAAATAAAATTCTCTATTGTAAATAAAATTTTTTCTTTGG ATCTTGGCAAT RREB 1-> CGGGATGGCAACTGCGGTCACCCTGCTAAAGTCGGGGCGGGGGCGGCGGT SEQ ID DSP CCTCCCCCTCACCCCCCCCAGTCCGAGCGCCGCCGCCGCCGCCGCCGCCGC NO: 8 1 CGCCGCGGCCGCTCAGTAACACGTCCCCAGGAGACTCGCAGGAGCAACAC GTGATGTGTCTACTTATCAGGTCAAACCGGCACGATGTCCAGGCACCAGAA CCAGAACACCATCCAGGAGCTGCTGCAGAACTGCTCCGACTGCTTGATGCG AGCAGAGCTCATCGTGCAGCCTGAATTGAAGTATGGAGATGGAATACAACT GACTCGGAGTCGAGAATTGGATGAGTGTTTTGCCCAGGCCAATGACCAAAT GGAAATCCTCGACAGCTTGATCAGAGAGATGCGGCAGATGGGCCAGCCCTG TGATGCTTACCAGAAAAGGCTTCTTCAGCTCCAAGAGCAAATGCGAGCCCT TTATAAAGCCATCAGTGTCCCTCGAGTCCGCAGGGCCAGCTCCAAGGGTGG TGGAGGCTACACTTGTCAGAGTGGCTCTGGCTGGGATGAGTTCACCAAACA TGTCACCAGTGAATGTTTGGGGTGGATGAGGCAGCAAAGGGCGGAGATGG ACATGGTGGCCTGGGGTGTGGACCTGGCCTCAGTGGAGCAGCACATTAACA GCCACCGGGGCATCCACAACTCCATCGGCGACTATCGCTGGCAGCTGGACA AAATCAAAGCCGACCTGCGCGAGAAATCTGCTATCTACCAGTTGGAGGAGG AGTATGAAAACCTGCTGAAAGCGTCCTTTGAGAGGATGGATCACCTGCGAC AGCTGCAGAACATCATTCAGGCCACGTCCAGGGAGATCATGTGGATCAATG ACTGCGAGGAGGAGGAGCTGCTGTACGACTGGAGCGACAAGAACACCAAC ATCGCTCAGAAACAGGAGGCCTTCTCCATACGCATGAGTCAACTGGAAGTT AAAGAAAAAGAGCTCAATAAGCTGAAACAAGAAAGTGACCAACTTGTCCT CAATCAGCATCCAGCTTCAGACAAAATTGAGGCCTATATGGACACTCTGCA GACGCAGTGGAGTTGGATTCTTCAGATCACCAAGTGCATTGATGTTCATCTG AAAGAAAATGCTGCCTACTTTCAGTTTTTTGAAGAGGCGCAGTCTACTGAA GCATACCTGAAGGGGCTCCAGGACTCCATCAGGAAGAAGTACCCCTGCGAC AAGAACATGCCCCTGCAGCACCTGCTGGAACAGATCAAGGAGCTGGAGAA AGAACGAGAGAAAATCCTTGAATACAAGCGTCAGGTGCAGAACTTGGTAA ACAAGTCTAAGAAGATTGTACAGCTGAAGCCTCGTAACCCAGACTACAGAA GCAATAAACCCATTATTCTCAGAGCTCTCTGTGACTACAAACAAGATCAGA AAATCGTGCATAAGGGGGATGAGTGTATCCTGAAGGACAACAACGAGCGC AGCAAGTGGTACGTGACGGGCCCGGGAGGCGTTGACATGCTTGTTCCCTCT GTGGGGCTGATCATCCCTCCTCCGAACCCACTGGCCGTGGACCTCTCTTGCA AGATTGAGCAGTACTACGAAGCCATCTTGGCTCTGTGGAACCAGCTCTACA TCAACATGAAGAGCCTGGTGTCCTGGCACTACTGCATGATTGACATAGAGA AGATCAGGGCCATGACAATCGCCAAGCTGAAAACAATGCGGCAGGAAGAT TACATGAAGACGATAGCCGACCTTGAGTTACATTACCAAGAGTTCATCAGA AATAGCCAAGGCTCAGAGATGTTTGGAGATGATGACAAGCGGAAAATACA GTCTCAGTTCACCGATGCCCAGAAGCATTACCAGACCCTGGTCATTCAGCTC CCTGGCTATCCCCAGCACCAGACAGTGACCACAACTGAAATCACTCATCAT GGAACCTGCCAAGATGTCAACCATAATAAAGTAATTGAAACCAACAGAGA AAATGACAAGCAAGAAACATGGATGCTGATGGAGCTGCAGAAGATTCGCA GGCAGATAGAGCACTGCGAGGGCAGGATGACTCTCAAAAACCTCCCTCTAG CAGACCAGGGATCTTCTCACCACATCACAGTGAAAATTAACGAGCTTAAGA GTGTGCAGAATGATTCACAAGCAATTGCTGAGGTTCTCAACCAGCTTAAAG ATATGCTTGCCAACTTCAGAGGTTCTGAAAAGTACTGCTATTTACAGAATG AAGTATTTGGACTATTTCAGAAACTGGAAAATATCAATGGTGTTACAGATG GCTACTTAAATAGCTTATGCACAGTAAGGGCACTGCTCCAGGCTATTCTCCA AACAGAAGACATGTTAAAGGTTTATGAAGCCAGGCTCACTGAGGAGGAAA CTGTCTGCCTGGACCTGGATAAAGTGGAAGCTTACCGCTGTGGACTGAAGA AAATAAAAAATGACTTGAACTTGAAGAAGTCGTTGTTGGCCACTATGAAGA CAGAACTACAGAAAGCCCAGCAGATCCACTCTCAGACTTCACAGCAGTATC CACTTTATGATCTGGACTTGGGCAAGTTCGGTGAAAAAGTCACACAGCTGA CAGACCGCTGGCAAAGGATAGATAAACAGATCGACTTTAGGTTATGGGACC TGGAGAAACAAATCAAGCAATTGAGGAATTATCGTGATAACTATCAGGCTT TCTGCAAGTGGCTCTATGATGCTAAACGCCGCCAGGATTCCTTAGAATCCAT GAAATTTGGAGATTCCAACACAGTCATGCGGTTTTTGAATGAGCAGAAGAA CTTGCACAGTGAAATATCTGGCAAACGAGACAAATCAGAGGAAGTACAAA AAATTGCTGAACTTTGCGCCAATTCAATTAAGGATTATGAGCTCCAGCTGG CCTCATACACCTCAGGACTGGAAACTCTGCTGAACATACCTATCAAGAGGA CCATGATTCAGTCCCCTTCTGGGGTGATTCTGCAAGAGGCTGCAGATGTTCA TGCTCGGTACATTGAACTACTTACAAGATCTGGAGACTATTACAGGTTCTTA AGTGAGATGCTGAAGAGTTTGGAAGATCTGAAGCTGAAAAATACCAAGAT CGAAGTTTTGGAAGAGGAGCTCAGACTGGCCCGAGATGCCAACTCGGAAA ACTGTAATAAGAACAAATTCCTGGATCAGAACCTGCAGAAATACCAGGCAG AGTGTTCCCAGTTCAAAGCGAAGCTTGCGAGCCTGGAGGAGCTGAAGAGAC AGGCTGAGCTGGATGGGAAGTCGGCTAAGCAAAATCTAGACAAGTGCTAC GGCCAAATAAAAGAACTCAATGAGAAGATCACCCGACTGACTTATGAGATT GAAGATGAAAAGAGAAGAAGAAAATCTGTGGAAGACAGATTTGACCAACA GAAGAATGACTATGACCAACTGCAGAAAGCAAGGCAATGTGAAAAGGAGA ACCTTGGTTGGCAGAAATTAGAGTCTGAGAAAGCCATCAAGGAGAAGGAG TACGAGATTGAAAGGTTGAGGGTTCTACTGCAGGAAGAAGGCACCCGGAA GAGAGAATATGAAAATGAGCTGGCAAAGGTAAGAAACCACTATAATGAGG AGATGAGTAATTTAAGGAACAAGTATGAAACAGAGATTAACATTACGAAG ACCACCATCAAGGAGATATCCATGCAAAAAGAGGATGATTCCAAAAATCTT AGAAACCAGCTTGATAGACTTTCAAGGGAAAATCGAGATCTGAAGGATGA AATTGTCAGGCTCAATGACAGCATCTTGCAGGCCACTGAGCAGCGAAGGCG AGCTGAAGAAAACGCCCTTCAGCAAAAGGCCTGTGGCTCTGAGATAATGCA GAAGAAGCAGCATCTGGAGATAGAACTGAAGCAGGTCATGCAGCAGCGCT CTGAGGACAATGCCCGGCACAAGCAGTCCCTGGAGGAGGCTGCCAAGACC ATTCAGGACAAAAATAAGGAGATCGAGAGACTCAAAGCTGAGTTTCAGGA GGAGGCCAAGCGCCGCTGGGAATATGAAAATGAACTGAGTAAGGTAAGAA ACAATTATGATGAGGAGATCATTAGCTTAAAAAATCAGTTTGAGACCGAGA TCAACATCACCAAGACCACCATCCACCAGCTCACCATGCAGAAGGAAGAG GATACCAGTGGCTACCGGGCTCAGATAGACAATCTCACCCGAGAAAACAG GAGCTTATCTGAAGAAATAAAGAGGCTGAAGAACACTCTAACCCAGACCA CAGAGAATCTCAGGAGGGTGGAAGAAGACATCCAACAGCAAAAGGCCACT GGCTCTGAGGTGTCTCAGAGGAAACAGCAGCTGGAGGTTGAGCTGAGACA AGTCACTCAGATGCGAACAGAGGAGAGCGTAAGATATAAGCAATCTCTTGA TGATGCTGCCAAAACCATCCAGGATAAAAACAAGGAGATAGAAAGGTTAA AACAACTGATCGACAAAGAAACAAATGACCGGAAATGCCTGGAAGATGAA AACGCGAGATTACAAAGGGTCCAGTATGACCTGCAGAAAGCAAACAGTAG TGCGACGGAGACAATAAACAAACTGAAGGTTCAGGAGCAAGAACTGACAC GCCTGAGGATCGACTATGAAAGGGTTTCCCAGGAGAGGACTGTGAAGGAC CAGGATATCACGCGGTTCCAGAACTCTCTGAAAGAGCTGCAGCTGCAGAAG CAGAAGGTGGAAGAGGAGCTGAATCGGCTGAAGAGGACCGCGTCAGAAGA CTCCTGCAAGAGGAAGAAGCTGGAGGAAGAGCTGGAAGGCATGAGGAGGT CGCTGAAGGAGCAAGCCATCAAAATCACCAACCTGACCCAGCAGCTGGAG CAGGCATCCATTGTTAAGAAGAGGAGTGAGGATGACCTCCGGCAGCAGAG GGACGTGCTGGATGGCCACCTGAGGGAAAAGCAGAGGACCCAGGAAGAGC TGAGGAGGCTCTCTTCTGAGGTCGAGGCCCTGAGGCGGCAGTTACTCCAGG AACAGGAAAGTGTCAAACAAGCTCACTTGAGGAATGAGCATTTCCAGAAG GCGATAGAAGATAAAAGCAGAAGCTTAAATGAAAGCAAAATAGAAATTGA GAGGCTGCAGTCTCTCACAGAGAACCTGACCAAGGAGCACTTGATGTTAGA AGAAGAACTGCGGAACCTGAGGCTGGAGTACGATGACCTGAGGAGAGGAC GAAGCGAAGCGGACAGTGATAAAAATGCAACCATCTTGGAACTAAGGAGC CAGCTGCAGATCAGCAACAACCGGACCCTGGAACTGCAGGGGCTGATTAAT GATTTACAGAGAGAGAGGGAAAATTTGAGACAGGAAATTGAGAAATTCCA AAAGCAGGCTTTAGAGGCATCTAATAGGATTCAGGAATCAAAGAATCAGTG TACTCAGGTGGTACAGGAAAGAGAGAGCCTTCTGGTGAAAATCAAAGTCCT GGAGCAAGACAAGGCAAGGCTGCAGAGGCTGGAGGATGAGCTGAATCGTG CAAAATCAACTCTAGAGGCAGAAACCAGGGTGAAACAGCGCCTGGAGTGT GAGAAACAGCAAATTCAGAATGACCTGAATCAGTGGAAGACTCAATATTCC CGCAAGGAGGAGGCTATTAGGAAGATAGAATCGGAAAGAGAAAAGAGTGA GAGAGAGAAGAACAGTCTTAGGAGTGAGATCGAAAGACTCCAAGCAGAGA TCAAGAGAATTGAAGAGAGGTGCAGGCGTAAGCTGGAGGATTCTACCAGG GAGACACAGTCACAGTTAGAAACAGAACGCTCCCGATATCAGAGGGAGAT TGATAAACTCAGACAGCGCCCATATGGGTCCCATCGAGAGACCCAGACTGA GTGTGAGTGGACCGTTGACACCTCCAAGCTGGTGTTTGATGGGCTGAGGAA GAAGGTGACAGCAATGCAGCTCTATGAGTGTCAGCTGATCGACAAAACAAC CTTGGACAAACTATTGAAGGGGAAGAAGTCAGTGGAAGAAGTTGCTTCTGA AATCCAGCCATTCCTTCGGGGTGCAGGATCTATCGCTGGAGCATCTGCTTCT CCTAAGGAAAAATACTCTTTGGTAGAGGCCAAGAGAAAGAAATTAATCAG CCCAGAATCCACAGTCATGCTTCTGGAGGCCCAGGCAGCTACAGGTGGTAT AATTGATCCCCATCGGAATGAGAAGCTGACTGTCGACAGTGCCATAGCTCG GGACCTCATTGACTTCGATGACCGTCAGCAGATATATGCAGCAGAAAAAGC TATCACTGGTTTTGATGATCCATTTTCAGGCAAGACAGTATCTGTTTCAGAA GCCATCAAGAAAAATTTGATTGATAGAGAAACCGGAATGCGCCTGCTGGAA GCCCAGATTGCTTCAGGGGGTGTAGTAGACCCTGTGAACAGTGTCTTTTTGC CAAAAGATGTCGCCTTGGCCCGGGGGCTGATTGATAGAGATTTGTATCGAT CCCTGAATGATCCCCGAGATAGTCAGAAAAACTTTGTGGATCCAGTCACCA AAAAGAAGGTCAGTTACGTGCAGCTGAAGGAACGGTGCAGAATCGAACCA CATACTGGTCTGCTCTTGCTTTCAGTACAGAAGAGAAGCATGTCCTTCCAAG GAATCAGACAACCTGTGACCGTCACTGAGCTAGTAGATTCTGGTATATTGA GACCGTCCACTGTCAATGAACTGGAATCTGGTCAGATTTCTTATGACGAGG TTGGTGAGAGAATTAAGGACTTCCTCCAGGGTTCAAGCTGCATAGCAGGCA TATACAATGAGACCACAAAACAGAAGCTTGGCATTTATGAGGCCATGAAAA TTGGCTTAGTCCGACCTGGTACTGCTCTGGAGTTGCTGGAAGCCCAAGCAG CTACTGGCTTTATAGTGGATCCTGTTAGCAACTTGAGGTTACCAGTGGAGG AAGCCTACAAGAGAGGTCTGGTGGGCATTGAGTTCAAAGAGAAGCTCCTGT CTGCAGAACGAGCTGTCACTGGGTATAATGATCCTGAAACAGGAAACATCA TCTCTTTGTTCCAAGCCATGAATAAGGAACTCATCGAAAAGGGCCACGGTA TTCGCTTATTAGAAGCACAGATCGCAACCGGGGGGATCATTGACCCAAAGG AGAGCCATCGTTTACCAGTTGACATAGCATATAAGAGGGGCTATTTCAATG AGGAACTCAGTGAGATTCTCTCAGATCCAAGTGATGATACCAAAGGATTTT TTGACCCCAACACTGAAGAAAATCTTACCTATCTGCAACTAAAAGAAAGAT GCATTAAGGATGAGGAAACAGGGCTCTGTCTTCTGCCTCTGAAAGAAAAGA AGAAACAGGTGCAGACATCACAAAAGAATACCCTCAGGAAGCGTAGAGTG GTCATAGTTGACCCAGAAACCAATAAAGAAATGTCTGTTCAGGAGGCCTAC AAGAAGGGCCTAATTGATTATGAAACCTTCAAAGAACTGTGTGAGCAGGAA TGTGAATGGGAAGAAATAACCATCACGGGATCAGATGGCTCCACCAGGGT GGTCCTGGTAGATAGAAAGACAGGCAGTCAGTATGATATTCAAGATGCTAT TGACAAGGGCCTTGTTGACAGGAAGTTCTTTGATCAGTACCGATCCGGCAG CCTCAGCCTCACTCAATTTGCTGACATGATCTCCTTGAAAAATGGTGTCGGC ACCAGCAGCAGCATGGGCAGTGGTGTCAGCGATGATGTTTTTAGCAGCTCC CGACATGAATCAGTAAGTAAGATTTCCACCATATCCAGCGTCAGGAATTTA ACCATAAGGAGCAGCTCTTTTTCAGACACCCTGGAAGAATCGAGCCCCATT GCAGCCATCTTTGACACAGAAAACCTGGAGAAAATCTCCATTACAGAAGGT ATAGAGCGGGGCATCGTTGACAGCATCACGGGTCAGAGGCTTCTGGAGGCT CAGGCCTGCACAGGTGGCATCATCCACCCAACCACGGGCCAGAAGCTGTCA CTTCAGGACGCAGTCTCCCAGGGTGTGATTGACCAAGACATGGCCACCAGG CTGAAGCCTGCTCAGAAAGCCTTCATAGGCTTCGAGGGTGTGAAGGGAAAG AAGAAGATGTCAGCAGCAGAGGCAGTGAAAGAAAAATGGCTCCCGTATGA GGCTGGCCAGCGCTTCCTGGAGTTCCAGTACCTCACGGGAGGTCTTGTTGA CCCGGAAGTGCATGGGAGGATAAGCACCGAAGAAGCCATCCGGAAGGGGT TCATAGATGGCCGCGCCGCACAGAGGCTGCAAGACACCAGCAGCTATGCCA AAATCCTGACCTGCCCCAAAACCAAATTAAAAATATCCTATAAGGATGCCA TAAATCGCTCCATGGTAGAAGATATCACTGGGCTGCGCCTTCTGGAAGCCG CCTCCGTGTCGTCCAAGGGCTTACCCAGCCCTTACAACATGTCTTCGGCTCC GGGGTCCCGCTCCGGCTCCCGCTCGGGATCTCGCTCCGGATCTCGCTCCGG GTCCCGCAGTGGGTCCCGGAGAGGAAGCTTTGACGCCACAGGGAATTCTTC CTACTCTTATTCCTACTCATTTAGCAGTAGTTCTATTGGGCACTAGTAGTCA GTTGGGAGTGGTTGCTATACCTTGACTTCATTTATATGAATTTCCACTTTATT AAATAATAGAAAAGAAAATCCCGGTGCTTGCAGTAGAGTGATAGGACATTC TATGCTTACAGAAAATATAGCCATGATTGAAATCAAATAGTAAAGGCTGTT CTGGCTTTTTATCTTCTTAGCTCATCTTAAATAAGCAGTACACTTGGATGCA GTGCGTCTGAAGTGCTAATCAGTTGTAACAATAGCACAAATCGAACTTAGG ATTTGTTTCTTCTCTTCTGTGTTTCGATTTTTGATCAATTCTTTAATTTTGGAA GCCTATAATACAGTTTTCTATTCTTGGAGATAAAAATTAAATGGATCACTGA TATTTTAGTCATTCTGCTTCTCATCTAAATATTTCCATATTCTGTATTAGGAG AAAATTACCCTCCCAGCACCAGCCCCCCTCTCAAACCCCCAACCCAAAACC AAGCATTTTGGAATGAGTCTCCTTTAGTTTCAGAGTGTGGATTGTATAACCC ATATACTCTTCGATGTACTTGTTTGGTTTGGTATTAATTTGACTGTGCATGAC AGCGGCAATCTTTTCTTTGGTCAAAGTTTTCTGTTTATTTTGCTTGTCATATT CGATGTACTTTAAGGTGTCTTTATGAAGTTTGCTATTCTGGCAATAAACTTT TAGACTTTTGAAGTGTTTGTGTTTTAATTTAATATGTTTATAAGCATGTATA AACATTTAGCATATTTTTATCATAGGTCTAAAAATATTTGTTTACTAAATAC CTGTGAAGAAATACCATTAAAAAACTATTTGGTTCTGAATTCTTACTA CHIA-> AAAGCTTCATGAAACCTCCTCGTCTGTGCACGAACAGGTGGCCGACTCTGG SEQ ID ZNF138 AGCCCAGGCTGTTGCTTTCCAGTCTGGTGGTGAATCCTCCATAGTCTGCTCT NO:82 GTGTTCTCGTTTTGCCCAAGACCTTTGGCTAGAGCAGAACATAAAAGATTCT TTCCAAAAAGTGACACTGAGCAGATATGGAAAATATGGACATAAGAATTTA CAGTTAAGAAAAGGCTGTAAAAGTGTGGATGAGTGTAAGGGACACCAAGG AGGTTTTAATGGACTTAACCAATGTTTGAAAATTACCACAAGCAAAATATT TCAATGTAATAAATATGTAAAAGTCATGCATAAATTTTCAAATTCAAATAG ACACAAGATAAGACATACTGAAAATAAACATTTCAGATGTAAAGAATGTG ACAAATCACTTTGCATGCTTTCACGCCTAACTCAACATAAAAAAATTCATAC TAGAGAGAATTTCTACAAATGTGAAGAGTGTGGAAAAACCTTTAACTGGTC CACAAACCTTTCTAAACCTAAGAAAATTCATACTGGAGAAAAACCCTACAA ATGTGAAGTATGTGGAAAAGCCTTTCACCAATCCTCAATCCTTACTAAACAT AAGATAATTCGTACTGGAGAAAAACCCTATAAATGTGCACACTGTGGCAAA GCCTTTAAACAGTCCTCACACCTTACTAGACATAAGATAATTCATACTGAA GAGAAACCCTACAAATGTGAACAATGTGGCAAGGTCTTTAAGCAGTCCCCA ACCCTTACTAAACATCAGATAATTTATACTGGAGAGGAACCATACAAATGT GAGGAATGTGGCAAAGCTTTTAACCTATCTTAACAACTTACTGAACATAAG AAAATTTACACTAGAGAGAAAGCCTACAAATGTGAAGAATGTGGCAAAGC CTTTAACCAGTTTTCAACCCTTATTACACATAAGATAATTCATAGCGGAGAG AAACCCCACAAATGTGAAGAATGTGGCAGAGCTTTTAACCAGTCCGCAAAG CTCACTGAACATAAGTTAATTCATACTGGAGAAAAACCCTACAAATGTAAA GAATGTGGAAAAGCTTTTCACCGATACTCAATCCTTAGTACACATAAGAAA ATTCATACTGGGGAGAAACCCCACAAATGTGGAGAATGCGGAAAAGCCTTT AACTGGTCCTCAACTCTTATTACACATAAGATAATTCACAGTGGAGAAAAA CCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCAGTCCTCACACCTT ATGAGACATAAGAAAATTCATAGTAAAGAGAAACCCTACAAATGTGAACA GTGTGGCAAGGTCTTTAAGAAGTCCTCAACTCTTACTGCACATAAGATCATT CATACTGGAGAGAAACCTTACAAATGTGAGGAATGTGGCAAAGGTTTTAGC CAACTCTCAAACCTTACTAAACACAAGAAGATTCATACTAGAGAGAAACCC TACAAATGTGAAGAATGTGGCATATCTTTTAACCAGTTCTCACAACTTGCTA TACATAAGATGATTCACACTTGAATGAAACCCTACAAATGTGAACGATGTG GCAGTTGTTTTAACTAGTTCTCGAACTTTACTATGCATAAGAAAATTCAAAC TGGAGAGAAACTCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCAAGT CTCAACACTTACTATACATAAGATAATTTATACTGGAGCAAAACCTTGGAA ATTCAAAGAATGTGGTAAAACTTACAATCCTCAAAACTTCTTACACCTAAA ATTCATGCAGGAGAGAAACACCACAAATGTGAAAAATTTGGTAAATTCTTT AACAAGTCTTCAACCCTTTCTGCACATAATATAATTCATACTGGAGAGAAA CCCCACAAATATGAAGAATGTGGTAATGCTTTTAACCAATTCTCAAATCTTA CTAAACAAAATTAATACTGAAAATGTTACAAACCAGAAAAATGTGAAAAT GATTTTAACAAAACCTTCAAATTTTTCTAAACATAAAGGAAATCATACTGGT AAGAAATTATAAAAATGTGAAGAATGTGACAAAGCCTTTAAATGGTTGTCA CACTTGATTGTAGGTAAGATAATTCATACTGGCAGAAACTCCCAGAAGTGT GAAGAATATGGCAAAACTTTAATTCCTATACCTTATTGCACAGGAAAGCAT TTATACTTCAGAAAATGTTGTACTGATATAAAGAATGTAGAAAAGCCATTA ATATGTGCTTACATCTTATTCAACATTAGAGAGTTAGTACTTAATAAA ZNF569-> AGCAGCGGAACGATTCGATTCTTCTCAGCACCAAGTTGCGCTCCCAATCTCT SEQ ID SHFM1 CAGAGCTGGGCTCGCGGGAGGCCGCTCGTGCAAAACCTAGGCTGAGCTCCC NO:83 CTGCGCGGAGCTGTGAGCCCTGGAACACCGTGGTCTGCTTCTCAGGACGCG CAAACAGTGAAGCCAGTCCCGCCCGGGTGAGCCGCGGGGGCCTCTGGGAA GCGTCGCCCCTGGTGTAACGGACCGAGACTTGTGGCGCTCTCAGCCACCGA CAGCGCCGGCCTCAGTGCCGCCTCTGTCCCAGCCCGCGCCGGCTCTGCCAC TTTGGCAGCGTTAAGTGTGGAATCGGGGCCTGTGTCCGCGGGCTTGGTGAG TTCTTCATATATTAAGGATTCATTCATTCATAGACTCATTTATTGAAGGCTG TCTGTGTAACAGGCACAATCCTAGGTGCTTGGGATATAGCAGTGAACAAGA GACAAACCCCCTACTATCATGGTACTTACATTTTTGTGGGCTGGATAATAAA CAAGACTGGGCTGGCTTAGATGAAGATGAAGATGCACATGTCTGGGAGGAT AATTGGGATGATGACAATGTAGAGGATGACTTCTCTAATCAGTTACGAGCT GAACTAGAGAAACATGGTTATAAGATGGAGACTTCATAGCATCCAGAAGA AGTGTTGAAGTAACCTAAACTTGACCTGCTTAATACATTCTAGGGCAGAGA ACCCAGGATGGGACACTAAAAAAATGTGTTTATTTCATTATCTGCTTGGATT TATTTGTGTTTTTGTAACACAAAAAATAAATGTTTTGATATAA TRIM37- ATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATT SEQ ID > TGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCCAAACTGT NO: 84 BCAS3 GTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTC CTCATTGCCGTGCTCCACTCCAGCTACGAGAACTAGTAAATTGTCGTTGGGC AGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAA ACATGAAGAAAATGAAAAGGACAAATGTGAAAATCACCATGAAAAACTTA GTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTG GGGAGGAATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGA GCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGGCGTCT CATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGT AAGAAATGCAAAAGATGAGCGTGTTCGGGAAATTAGGAATGCAGTGGAGA TGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGA TGGGTCAGAAGACATCTCTAACCCAAGAAACAGAGCTTTTGGAATCCTTAC TTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATAT CTAAGAGCTCAGAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCA TGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGTGAATTAGT GCCATCTTACGATTCAGCTACTTTTGTTTTAGAGAATTTCAGCACTTTGCGT CAGAGAGCAGATCCTGTTTACAGTCCACCTCTTCAAGTTTCAGGACTTTGCT GGAGGTTAAAAGTTTACCCAGATGGAAATGGAGTTGTGCGAGGTTACTACT TATCTGTGTTTCTGGAGCTCTCAGCTGGCTTGCCTGAAACTTCTAAATATGA ATATCGTGTAGAGATGGTTCACCAGTCCTGTAATGATCCTACAAAAAATAT CATTCGAGAATTTGCATCTGACTTTGAAGTTGGAGAATGCTGGGGCTATAA TAGATTTTTCCGTTTGGACTTACTCGCAAATGAAGGATACTTGAATCCACAA AATGATACAGTGATTTTAAGGTTTCAGGTACGTTCACCAACTTTCTTTCAAA AATCCCGGGACCAGCATTGGTACATTACTCAGTTGGAAGCTGCACAGACTA GTTATATCCAACAAATAAACAACCTTAAAGAGAGACTTACTATTGAGCTGT CTCGAACTCAGAAGTCAAGAGATTTGTCACCACCAGATAACCATCTTAGCC CCCAAAATGATGATGCTCTGGAGACACGAGCTAAGAAGTCTGCATGCTCTG ACATGCTTCTCGAAGGTGGTCCTACTACAGCTTCTGTAAGAGAGGCCAAAG AGGATGAAGAAGATGAGGAGAAGATTCAGAATGAAGATTATCATCACGAG CTTTCAGATGGAGATCTGGATCTGGATCTTGTTTATGAGGATGAAGTAAATC AGCTCGATGGCAGCAGTTCCTCTGCTAGTTCCACAGCAACAAGTAATACAG AAGAAAATGATATTGATGAAGAAACTATGTCTGGAGAAAATGATGTGGAA TATAACAACATGGAATTAGAAGAGGGAGAACTCATGGAAGATGCAGCTGC TGCAGGACCCGCAGGTAGTAGCCATGGTTATGTGGGTTCCAGTAGTAGAAT ATCAAGAAGAACACATTTATGCTCCGCTGCTACCAGTAGTTTACTAGACATT GATCCATTAATTTTAATACATTTGTTGGACCTTAAGGACCGGAGCAGTATAG AAAATTTGTGGGGCTTACAGCCTCGCCCACCTGCTTCACTTCTGCAGCCCAC AGCATCATATTCTCGAAAAGATAAAGACCAAAGGAAGCAACAGGCAATGT GGCGAGTGCCCTCTGATTTAAAGATGCTAAAAAGACTCAAAACTCAAATGG CCGAAGTTCGATGTATGAAAACTGATGTAAAGAATACACTTTCAGAAATAA AAAGCAGCAGTGCTGCTTCTGGAGACATGCAGACAAGCCTTTTTTCTGCTG ACCAGGCAGCTCTGGCTGCATGTGGAACTGAAAACTCTGGCAGATTGCAGG ATTTGGGAATGGAACTCCTGGCAAAGTCATCAGTTGCCAATTGTTACATAC GAAACTCCACAAATAAGAAGAGTAATTCGCCCAAGCCAGCTCGATCCAGTG TAGCAGGTAGTCTATCACTTCGAAGAGCAGTGGACCCTGGAGAAAATAGTC GTTCAAAGGGAGACTGTCAGACTCTGTCTGAAGGCTCCCCAGGAAGCTCTC AGTCTGGGAGCAGGCACAGTTCTCCCCGAGCCTTGATACATGGCAGTATCG GTGATATTCTGCCAAAAACTGAAGACCGGCAGTGTAAAGCTTTGGATTCAG ATGCTGTTGTGGTTGCAGTTTTCAGTGGCTTGCCTGCGGTTGAGAAAAGGA GGAAAATGGTCACCTTGGGATACATCAAGAAATCTGGAATTTCATGAAATA CATAGTACTGGGAATGAACCGCCTTTGTTGATTATGATTGGCTACAGTGATG GAATGCAGGTCTGGAGCATCCCTATCAGTGGTGAAGCACAAGAGCTCTTCT CTGTTCGACATGGCCCAATTCGAGCGGCTAGAATCTTGCCTGCTCCACAGTT TGGTGCTCAAAAATGTGATAACTTTGCTGAAAAAAGACCCCTCCTTGGTGTT TGTAAGAGCATTGGATCTTCTGGCACAAGCCCACCGTACTGTTGTGTGGATC TGTATTCACTTCGTACTGGGGAGATGGTCAAGTCCATTCAATTTAAGACACC TATTTATGATCTCCATTGCAATAAACGGATCCTTGTCGTAGTCTTGCAGGAG AAAATTGCTGCCTTTGATAGCTGTACTTTCACGAAGAAATTCTTTGTTACAA GCTGCTATCCATGTCCAGGGCCAAACATGAATCCTATTGCTCTTGGGAGCC GCTGGCTTGCTTATGCAGAAAACAAGTTGATTCGATGTCATCAGTCCCGTG GTGGAGCCTGTGGAGACAACATTCAGTCTTATACTGCCACAGTCATTAGTG CTGCTAAAACATTGAAAAGTGGCCTGACAATGGTAGGGAAAGTGGTGACTC AGCTGACAGGCACACTGCCTTCAGGTGTGACAGAAGATGATGTTGCCATCC ACAGTAATTCACGGCGGAGTCCTTTGGTCCCAGGCATCATCACAGTTATTG ACACCGAAACCGTTGGAGAGGGCCAGGTGCTTGTGAGTGAGGATTCTGACA GTGATGGCATTGTGGCCCACTTCCCTGCCCATGAGAAGCCAGTGTGCTGCA TGGCTTTTAATACAAGTGGAATGCTTCTAGTCACAACAGACACCCTTGGCC ATGACTTTCATGTCTTCCAAATTCTGACTCATCCTTGGTCCTCATCACAATGT GCTGTCCACCATCTGTATACTCTTCACAGGGGAGAAACTGAAGCCAAAGTA CAGGACATCTGCTTCAGCCATGACTGTCGCTGGGTTGTGGTCAGTACTCTCC GGGGTACTTCCCACGTTTTCCCCATCAACCCTTATGGTGGCCAGCCTTGTGT TCGTACACATATGTCACCACGAGTAGTGAATCGCATGAGCCGTTTCCAGAA AAGTGCTGGACTGGAAGAGATTGAACAAGAACTGACGTCTAAGCAAGGAG GTCGCTGTAGCCCTGTTCCAGGTCTATCAAGCAGCCCTTCTGGGTCACCCTT GCATGGGAAACTGAACAGCCAAGACTCCTATAACAATTTTACCAACAACAA CCCTGGCAACCCTCGGCTCTCTCCTCTTCCCAGCTTGATGGTAGTGATGCCT CTTGCACAAATCAAGCAGCCAATGACATTGGGGACCATCACCAAACGAACC GGCAAAGTTAAACCTCCTCCACAAATTTCACCCAGCAAATCGATGGGCGGA GAATTTTGTGTGGCTGCTATCTTCGGAACATCCAGGTCATGGTTTGCAAATA ATGCAGGTCTGAAAAGAGAAAAAGATCAGTCCAAACAAGTTGTAGTTGAG TCCCTGTACATTATCAGTTGCTATGGCACCTTAGTGGAACACATGATGGAGC CGCGACCCCTCAGCACTGCACCCAAGATTAGTGACGACACACCACTGGAAA TGATGACATCGCCTCGAGCCAGCTGGACTCTGGTTAGAACCCCTCAATGGA ATGAATTGCAGCCACCGTTTAATGCAAACCACCCTCTGCTCCTCGCTGCAGA TGCAGTACAGTATTATCAGTTCCTGCTTGCTGGCCTGGTTCCCCCTGGAAGT CCTGGGCCCATTACTCGACATGGGTCTTACGACAGTTTAGCTTCTGACCATA GTGGACAGGAAGATGAAGAATGGCTTTCCCAGGTTGAAATTGTAACACACA CTGGACCCCATAGACGTCTGTGGATGGGTCCACAGTTCCAGTTCAAAACCA TCCATCCCTCAGGCCAAACCACAGTTATCTCATCCAGTTCATCTGTGTTGCA GTCTCATGGTCCGAGTGACACGCCACAGCCTCTTTTGGATTTTGATACAGAT GATCTTGATCTCAACAGTCTCAGGATCCAGCCAGTCCGCTCTGACCCCGTCA GCATGCCAGGGTCATCCCGTCCAGTCTCTGATCGAAGGGGAGTTTCCACAG TGATTGATGCTGCCTCAGGTACCTTTGACAGGAGCGTGACCCTGCTGGAGG TGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGCACATGTCCTCCATGG AGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCGACGCCATGGCCGAG TCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAACTTCAGCGAGAGGG AAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACCAGCGGCAGCATACC AAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACCAATGAGAGCCAGCC CCTCAGCCTCTTCCCGACTGGCTTCCCGTAG PPIL2-> ATGGGGAAGCGACAGCACCAAAAGGACAAAATATTCTCCAGCTATGTATCG SEQ ID NF2 GGAACCATGATCTATTTATGAGGAGAAGGAAAGCCGATTCTTTGGAAGTTC NO:85 AGCAGATGAAAGCCCAGGCCAGGGAGGAGAAGGCTAGAAAGCAGATGGA GCGGCAGCGCCTCGCTCGAGAGAAGCAGATGAGGGAGGAGGCTGAACGCA CGAGGGATGAGTTGGAGAGGAGGCTGCTGCAGATGAAAGAAGAAGCAACA ATGGCCAACGAAGCACTGATGCGGTCTGAGGAGACAGCTGACCTGTTGGCT GAAAAGGCCCAGATCACCGAGGAGGAGGCAAAACTTCTGGCCCAGAAGGC CGCAGAGGCTGAGCAGGAAATGCAGCGCATCAAGGCCACAGCGATTCGCA CGGAGGAGGAGAAGCGCCTGATGGAGCAGAAGGTGCTGGAAGCCGAGGTG CTGGCACTGAAGATGGCTGAGGAGTCAGAGAGGAGGGCCAAAGAGGCAGA TCAGCTGAAGCAGGACCTGCAGGAAGCACGCGAGGCGGAGCGAAGAGCCA AGCAGAAGCTCCTGGAGATTGCCACCAAGCCCACGTACCCGCCCATGAACC CAATTCCAGCACCGTTGCCTCCTGACATACCAAGCTTCAACCTCATTGGTGA CAGCCTGTCTTTCGACTTCAAAGATACTGACATGAAGCGGCTTTCCATGGA GATAGAGAAAGAAAAAGTGGAATACATGGAAAAGAGCAAGCATCTGCAGG AGCAGCTCAATGAACTCAAGACAGAAATCGAGGCCTTGAAACTGAAAGAG AGGGAGACAGCTCTGGATATTCTGCACAATGAGAACTCCGACAGGGGTGGC AGCAGCAAGCACAATACCATTAAAAAGCTCACCTTGCAGAGCGCCAAGTCC CGAGTGGCCTTCTTTGAAGAGCTCTAG LRP8-> ATGGGCCTCCCCGAGCCGGGCCCTCTCCGGCTTCTGGCGCTGCTGCTGCTGC SEQ ID TMEM48 TGCTGCTGCTGCTGCTGCTGCAGCTCCAGCATCTTGCGGCGGCAGCGGCTG NO:86 ATCCGCTGCTCGGCGGCCAAGGGCCGGCCAAGGATTGCGAAAAGGACCAA TTCCAGTGCCGGAACGAGCGCTGCATCCCCTCTGTGTGGAGATGCGACGAG GACGATGACTGCTTAGACCACAGCGACGAGGACGACTGCCCCAAGAAGAC CTGTGCAGACAGTGACTTCACCTGTGACAACGGCCACTGCATCCACGAACG GTGGAAGTGTGACGGCGAGGAGGAGTGTCCTGATGGCTCCGATGAGTCCGA GGCCACTTGCACCAAGCAGGTGTGTCCTGCAGAGAAGCTGAGCTGTGGACC CACCAGCCACAAGTGTGTACCTGCCTCGTGGCGCTGCGACGGGGAGAAGGA CTGCGAGGGTGGAGCGGATGAGGCCGGCTGTGCTACCTGCTATATTCCCAA AGCTTGGATTAGCACTGCTATGAACCTTCACATAGATGAGCAGGTTCATAG GCCACTTGACACAGTGAGTGGCCTCTTAAATCTCTCGTTACTCTACCATGTC TGGCTGTGTGGTGTCTTTCTCCTGACGACTTGGTATGTCTCATGGATACTCTT CAAAATCTATGCCACAGAGGCTCATGTGTTTCCTGTTCAACCACCATTTGCA GAAGGGTCAGATGAGTGCCTTCCAAAAGTGTTAAATAGCAATCCTCCCCCC ATCATAAAGTATTTAGCCTTGCAGGACCTGATGTTGCTTTCTCAATATTCTC CTTCACGAAGACAAGAAGTTTTCAGCCTCAGCCAACCAGGTGGACATCCCC ACAATTGGACAGCCATTTCAAGGGAGTGTTTGAATCTTTTAAATGGTATGA CTCAGAAACTGATTCTCTATCAAGAAGCTGCTGCTACGAATGGGAGAGTGT CTTCATCTTACCCAGTGGAACCTAAGAAATTAAATTCTCCAGAAGAAACTG CTTTTCAGACACCAAAATCTAGCCAGATGCCTCGGCCTTCAGTGCCACCATT AGTTAAAACATCACTGTTTTCTTCAAAATTATCTACACCTGATGTTGTGAGC CCATTTGGGACCCCATTTGGCTCTAGTGTAATGAATCGGATGGCTGGAATTT TTGATGTAAACACCTGCTATGGGTCACCGCAAAGTCCTCAGCTAATAAGAA GGGGGCCAAGATTGTGGACATCAGCTTCTGATCAGCAAATGACTGAATTTT CTAATCCTTCTCCATCTACCTCTATTAGTGCTGAGGGTAAGACAATGAGACA ACCCAGTGTGATTTATTCATGGATTCAGAATAAACGTGAACAGATTAAGAA TTTCTTGTCAAAACGGGTGCTGATAATGTATTTTTTCAGTAAGCACCCAGAG GCCTCCATTCAGGCTGTTTTTTCAGATGCCCAAATGCATATTTGGGCATTAG AAGGTCTGTCGCACTTAGTAGCAGCATCATTTACAGAGGATAGATTTGGAG TTGTCCAGACGACACTACCAGCTATCCTTAATACTTTGTTGACACTGCAAGA GGCAGTCGACAAGTACTTTAAGCTTCCTCATGCTTCCAGTAAACCACCCCG GATTTCAGGAAGCCTTGTGGACACTTCATATAAAACATTAAGATTTGCATTC AGAGCATCACTGAAAACTGCCATCTATCGAATAACTACTACATTTGGTGAA CATCTGAATGCTGTGCAAGCATCTGCAGAACATCAGAAAAGACTTCAACAG TTCTTGGAGTTCAAAGAATAG LUC7L3- ATGATTTCGGCCGCGCAGTTGTTGGATGAGTTAATGGGCCGGGACCGAAAC SEQ ID > CTAGCCCCGGACGAGAAGCGCAGCAACGTGCGGTGGGACCACGAGAGCTG NO:87 HNFIB TCCTCTACAAGCCTGGTGA RAD21-> ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTT SEQ ID FER1L6 GGCTAGCGGCCCATTGGGATAAGAAGCTAACCAAAGCCCATGTGTTCGAGT NO:88 GTAATTTAGAGAGCAGCGTGGAGAGTATCATCTCACCAAAGATGTTTGGGC TGAAGGTGAAGAAGAAGAGAAATAAGGCAGAGAAGGGGTTAATCCTAGCC AACAAGGCTGCGAAAGATAGTCAAGGTGACACTGAAGCACTGCAGGAGGA GCCTTCTCACCAGGAAGGACCGAGAGGAGATTTGGTCCATGATGATGCTTC TATCTTTCCTGTCCCCTCAGCTTCTCCAAAGAGAAGATCAAAACTGTTGACT AAGATCCATGATGGGGAGGTCAGATCCCAAAATTATCAAATTGCCATAACC ATCACCGAGGCTCGCCAGCTGGTGGGTGAGAACATTGACCCAGTTGTGACC ATTGAGATTGGGGATGAGAAGAAGCAAAGCACAGTGAAGGAAGGAACCAA CAGCCCATTTTATAATGAATACTTTGTCTTCGACTTCATTGGGCCCCAAGTG CATCTTTTTGACAAGATCATCAAAATCTCCGTCTTTCACCACAAGCTGATAG GAAGTGTACTGATTGGCTCTTTCAAAGTAGACCTGGGGACCGTGTACAACC AACCTGGTCATCAGTTCTGCAACAAGTGGGCCCTGCTCACAGACCCTGGTG ACATCAGGACTGGCACCAAGGGGTACCTGAAATGTGACATCAGTGTCATGG GAAAAGGTGATGTCTTGAAGACCAGCCCTAAAACTTCTGACACCGAGGAGC CAATAGAAAAGAACCTTTTGATCCCCAATGGGTTTCCACTGGAGAGACCGT GGGCCAGATTCTATGTGAGACTCTACAAAGCAGAAGGGTTGCCCAAAATGA ATTCAAGCATCATGGCGAACGTCACCAAGGCATTTGTGGGTGACAGTAAGG ACCTGGTGGATCCCTTTGTGGAGGTCTCCTTTGCTGGGCAGATGGGGCGAA CCACAGTGCAGAAGAACTGTGCTGATCCTGTGTGGCATGAACAGGTGATCT TCAAGGAAATGTTCCCTCCCTTGTGTCGGAGGGTGAAAATCCAGGTGTGGG ATGAAGGCAGCATGAATGACGTAGCCCTGGCAACCCATTTCATTGACCTGA AGAAAATCTCCAACGAACAGGATGGAGACAAAGGCTTTCTGCCCACCTTTG GGCCTGCCTGGATTAACCTGTATGGCTCGCCCAGGAACCACAGTCTGATGG ATGACTACCAGGAAATGAACGAAGGCTTTGGGGAAGGTGTGTCATTCAGGG GCAGAATCTTGGTAGAAATTGCTGTGGAAATCCTCTCAGGACGGGCACAGG AATCTAAATTTTCCAAGGCCCTGAAGGAGCTCAAGTTGCCTTCCAAGGACA AAGACTCCAAATCTTCCAAAGGTAAAGACAAGGCTGACAAAACTGAAGAT GGAAAATCCCAACAGGCTTCAAACAAAACTAACTCAACCGAGGTGGAGGT GGAATCGTTCGATGTCCCCCCGGAGATTGTACCAGAAAAAAATGAGGAATT TTTACTCTTTGGAGCATTTTTTGAAGCTACCATGATTGACCGGAAGATTGGA GATAAACCCATCAGCTTTGAAGTTTCTATTGGTAATTTTGGAAACCTGATTG ATGGAGGATCCCATCATGGGAGTAAGAAGTCAGCTGAATCAGCTGAAGAA GACCTCCTTCCACTGCTTCACGAAGGGCAAGGGGATGTGGCCCATGATGTT CCCATTCCTATGGCCTCCACCACTCACCCGGAGAAGCCACTGGTGACAGAA GGGAACAGGAATTACAACTATTTGCCATTTGAGGCTAAGAAGCCCTGTGTC TATTTCATCAGCTCTTGGGGAGACCAGACCTTCAGGCTGCACTGGTCCAAC ATGCTGGAGAAAATGGCAGACTTCCTGGAAGAAAGTATAGAAGAAGTGAG AGAATTGATCAAGATTTCACAGGAGGCACCTGAAGAGAAAATGAAAACAG TGCTCAGTGACTTCATCAGTCGGAGCAGTGCCTTTATCTCTGAAGCAGAAA AAAAGCCCAAGATGTTGAACCAAACCACTTTAGATAAGAAGCGACTTACGC TCTGCTGGCAGGAGCTGGAAGCAATGTGCAAGGAGGCCAAGGGGATCATT CAGCAGCAGAAGAAAAAGTTATCTGTTGATGAAATGATTCACGAAGCCCAA AACTTTGTGGAAAAAATCCGCTTTCTTGTTGATGAGCCCCAGCACACTATCC CTGACGTTTTCATCTGGATGCTCAGCAACAACAGGAGAGTGGCCTATGCCC GCATCGCCTCCAAAGACCTCCTCTATTCCCCTGTCGCGGGGCAGATGGGCA AACACTGCGGCAAGATCAAAACTCACTTCCTCAAACCTCCTGGGAAACGAC CGGCTGGTTGGTCTGTGCAAGCAAAAGTCGACGTGTACCTGTGGCTGGGCT CCATCAAGCATGCCAGTGCCATTTTGGACAACTTGCCAGTAGGCTATGAAG CAGAAATGTCCTCCAAAGGGGCTGGCACCAATCACCCCCCATCTAACCTGC TCTACCAAGAACAGCATGTTTTTCAGCTGAGGGCTCACATGTACCAAGCCC GGGGCCTCATCGCAGCTGACAGCAATGGACTTTCAGACCCTTTTGCCAAAG TCACGTTCCTTTCTCACTGCCAGACAACAAAGATAATCTCCCAGACCCTCTC TCCGACCTGGAACCAGATGCTGCTGTTCAATGATTTGGTGCTGCATGGAGA TGTGAAGGAGCTGGCAGAGTCCCCGCCCTTAGTGGTGGTGGAGCTGTATGA CAGCGACGCTGTGGGGAAGCCAGAATATTTGGGTGCCACAGTGGCTGCTCC TGTTGTGAAGCTGGCTGACCAGGACTATGAGCCCCCCAGGTTATGCTATCA CCCCATCTTTTGTGGGAATCTCTCTGGAGGGGATCTCCTTGCTGTATTTGAA CTGCTGCAGGTTCCTCCTTCTGGGCTGCAAGGCCTCCCACCCGTTGAGCCAC CAGACATCACCCAGATCTACCCGGTTCCTGCCAACATTCGGCCGGTGCTGA GCAAATACCGAGTGGAGGTTCTCTTCTGGGGAGTTCGGGAAATGAAGAAGG TGCAGCTCCTCTCTGTGGATCGGCCTCAGGCTCTCATTGAGTGCGGAGGAC AAGGTGTGAAGTCCTGCGTGATCCAGAGCTACAAGAACAACCCGAACTTCA GCATCCAGGCAGACGCTTTCGAAGTGGAACTGCCTGAGAACGAGCTTCTGC ACCCGCCACTGAGCATCTGCGTGGTGGACTGGAGAGCTTTTGGGAGGAGTA CCCTTGTGGGCACCTACACCATCAACTACTTGAAGCAGTTTTTGTGTAAACT CAGAGAGCCCCTTGCCCCCATCACACAGGTGGATGGAACCCAGCCTGGGCA CGATATTTCAGATTCGCTAACAGCCACTGAGTCCTCTGGAGCCCACAGCTCC TCCCAGGATCCCCCAGCAGATCACATTTATGTGGATGTTGAGCCACCTCCCA CAGTGGTGCCCGACTCTGCCCAGGCCCAGCCGGCCATCCTGGTTGACGTCC CTGACTCATCCCCGATGCTGGAGCCTGAACACACACCTGTAGCCCAGGAGC CACCAAAAGATGGAAAACCTAAGGATCCCAGGAAGCCTTCCCGGAGGTCC ACTAAGAGGAGAAAGAGGACCATAGCAGATGAATCTGCTGAAAACGTGAT TGACTGGTGGTCTAAGTATTATGCCTCCCTGAAGAAAGCCCAGAAGGCAAA GGAGAGAAATCCCAAGGGAAAAAAAGGCAATACAGAGGCAAAGCCAGAT GAGGTAGTGGTAGATATAGAAGATGGGCCAAAGAAGAAGAAAGACAAAAT GCTCAAGAAGAAACCCAAAGATGATGGAATCCCCAACCTGGCCATCTTGCA GATATATGACGGTGATCTCGAGAGTGAATTCAACAATTTTGAAGACTGGGT GAAAACTTTTGAGCTCTTCAGAGGCAAGTCTACGGAAGATGACCATGGTCT TGATGGAGACCGAGTCATAGGAAAATTTAAGGGCTCCTTCTGCATCTACAA AAGCCCCCAGGATTCTAGCTCTGAGGACAGCGGGCAGCTGAGAATCCAGCA AGGGATTCCGCCCAATCACCCTGTCACAGTGCTGATCAGAGTATACATTGT CGCGGCATTTAATCTTAGTCCAGCTGATCCAGATGGCAAATCAGATCCCTA CATTGTGATCAAGCTTGGCAAGACAGAAATCAAAGACCGGGATAAATACAT CCCTAAACAACTGAACCCAGTATTTGGAAGGTCATTTGAGATCCAAGCCAC ATTCCCAAAAGAGTCCCTGCTCTCCATCCTGATCTATGACCATGACATGATT GGCACAGATGACCTTATTGGTGAGACCAAGATCGACCTGGAGAACCGCTTC TACAGCAAACACCGAGCCATCTGTGGCTTGCAGAGCCAGTATGAGATAGAA GGATACAATGCCTGGAGAGACACGTCCAAACCCACCGAAATCCTCACTAAG CTCTGCAAAGACAACAAGCTGGATGGACCCTACTTTCACCCTGGGAAAATA CAGATAGGAAACCAAGTCTTTTCTGGAAAAACTATCTTCACTGAAGAGGAC ACTGATGAGACAGTGGAGTCTTATGAACACCTGGCCCTCAAGGTTTTACAC TCTTGGGAGGATATCCCGGAAGTCGGGTGTAGGCTGGTTCCTGAACACATA GAAACTCGGCCACTGTACCACAAGGATAAGCCAGGAATGGAGCAGGGCCG CCTGCAGATGTGGGTGGACATGTTTCCCAAGGATATGCCTCAACCTGGACC TCCTGTTGACATCTCTCCAAGGCGACCCAAAGGATACGAATTGAGAGTGAC CATCTGGAACACTGAAGATGTCATTTTAGAGGATGAGAATATCTTCACAGG CCAAAAATCAAGTGATATTTATGTGAAAGGGTGGTTAAAGGGCTTGGAGGA TGACAAGCAGGAGACAGATGTGCATTACAACTCCCTGACTGGAGAGGGCA ACTTCAACTGGCGCTTCCTGTTTCCCTTTCAGTATCTCCCAGCTGAGAAGCA AATGGTCATTACCAAGAGGGAGAACATCTTCTCTTTAGAGAAGATGGAGTG TAAGACTCCTGCTGTGTTGGTGCTGCAGGTTTGGGATTTTGAAAGGCTGTCC TCAGATGACTTCCTGGGCACCCTGGAAATGAACCTCAACAGTTTCCCTCGA GCAGCTAAGTCTGCCAAAGCCTGTGATCTTGCCAAGTTTGAAAATGCAAGT GAGGAGACCAAGATCTCTATATTCCAGCAAAAACGTGTGCGTGGCTGGTGG CCTTTTTCTAAAAGCAAAGAACTCACAGGCAAGGTTGAAGCTGAGTTCCAC CTAGTTACAGCAGAAGAAGCTGAGAAAAATCCTGTTGGAAAAGCCCGAAA GGAGCCAGAGCCCCTGGCCAAGCCCAACCGCCCAGACACCTCCTTTTCGTG GTTCATGAGCCCCTTTAAGTGCCTGTACTACCTCATCTGGAAGAATTACAAA AAGTACATCATCATTGCTTTCATTCTCATCATCCTCATCATCTTCCTCGTCCT TTTCATCTACACCTTGCCAGGAGCCATCAGCCGAAGGATCGTTGTGGGCTC ATAG ΑΡ2Β1-> ATGACTGACTCCAAGTATTTCACAACCAATAAAAAAGGAGAAATATTTGAA SEQ ID FLJ42280 CTAAAAGCTGAACTCAACAATGAAAAGAAAGAAAAGAGAAAGGAGGCTGT NO:89 GAAGAAAGTGATTGCTGCTATGACCGTGGGGAAGGATGTTAGTTCTCTCTT TCCAGACGTAGTGAACTGTATGCAGACTGACAATCTGGAACTAAAGAAGCT TGTGTATCTCTACTTGATGAACTACGCCAAGAGTCAGCCAGACATGGCCAT CATGGCTGTAAACAGCTTTGTGAAGGACTGTGAAGATCCTAATCCTTTGATT CGAGCCTTGGCAGTCAGAACCATGGGGTGCATCCGGGTAGACAAAATTACA GAATATCTCTGTGAGCCGCTCCGCAAGTGCTTGAAGGATGAGGATCCCTAT GTTCGGAAAACAGCAGCAGTCTGCGTGGCAAAACTCCATGATATCAATGCC CAAATGGTGGAAGATCAGGGATTTCTGGATTCTCTACGGGATCTCATAGCA GATTCAAATCCAATGGTGGTGGCTAATGCCGTAGCGGCATTATCTGAAATC AGTGAGTCTCACCCAAACAGCAACTTACTTGATCTGAACCCACAGAACATT AATAAGCTGCTGACAGCCCTGAATGAATGCACTGAATGGGGCCAGATTTTC ATCCTGGACTGCCTGTCTAATTACAACCCTAAAGATGATCGGGAGGCTCAG AGCATCTGTGAGCGGGTAACTCCCCGGCTATCCCATGCCAACTCAGCAGTG GTGCTTTCAGCGGTAAAAGTCCTAATGAAGTTTCTAGAATTGTTACCTAAGG ATTCTGACTACTACAATATGCTGCTGAAGAAGTTAGCCCCTCCACTTGTCAC TTTGCTGTCTGGGGAGCCAGAAGTGCAGTATGTCGCCCTGAGGAACATCAA CTTAATTGTCCAGAAAAGGCCTGAAATCTTGAAGCAGGAAATCAAAGTCTT CTTTGTGAAGTACAATGATCCCATCTATGTTAAACTAGAGAAGTTGGACAT CATGATTCGTTTGGCATCTCAAGCCAACATTGCTCAGGTTCTGGCAGAACTG AAAGAATATGCTACAGAGGTGGATGTTGACTTTGTTCGAAAAGCTGTGCGG GCCATTGGACGGTGTGCCATCAAGGTGGAGCAATCTGCAGAGCGCTGTGTA AGCACATTGCTTGATCTAATCCAGACCAAAGTGAATTATGTGGTCCAAGAA GCAATTGTTGTCATCAGGGACATCTTCCGCAAATACCCCAACAAGTATGAA AGTATCATCGCCACTCTGTGTGAGAACTTAGACTCGCTGGATGAGCCAGAT GCTCGAGCAGCTATGATTTGGATTGTGGGAGAATATGCTGAAAGAATTGAC AATGCAGATGAGTTACTAGAAAGCTTCCTGGAGGGTTTTCACGATGAAAGC ACCCAGGTGCAGCTCACTCTGCTTACTGCCATAGTGAAGCTGTTTCTCAAGA AACCATCAGAAACACAGGAGCTAGTCCAGCAGGTCTTGAGTTTGGCAACAC AGGACTCCAACATTTGTGCTGTGTTTGCTGTACAAGGAGGAAAAGTGGGAA GAAAGCATGGCATAAAAAGGGGGAGGAGACCCAGCATAAGAAGCCCAGCT CAGCGGGCCAGAGGACCCTGGATCCATGAGAGTAAGCATCCGGCCTTTGCA AAGCAACAGATAAACTTGGAGATGCCCAACTCCAGAGCGACAACAGAGTT AGCCTGGGTCTGCAGCTCCACCTCAAGAAAAAAGAAGTGGGCAAGGTCCCT GACTCTTTCCACTGCTCCACTGAGCCCCCCACCATCCTTGGTGCACTGTGAA GATTGTTCTTGCCTGCCTGGCTGCCATTCGGGTGACCTCTACAATCTGGCCC CAGCAGAAAGAACTTGCTAG RUFY3-> ATGTCTGCTCTGACGCCTCCGACCGATATGCCAACCCCCACCACTGACAAG SEQ ID MUC7 ATCACACAGGCTGCCATGGAGACCATCTACCTTTGCAAATTCCGAGTGTCC NO:90 ATGGATGGAGAATGGCTCTGCCTGCGAGAGCTGGATGACATCTCACTTACA CCTGACCCAGAGCCTACCCATGAAGATCCTAATTATCTCATGGCTAATGAA CGCATGAACCTCATGAACATGGCCAAGCTGAGTATCAAGGGCTTGATTGAA TCAGCTCTGAACCTGGGGAGGACTCTTGACTCTGACTATGCACCTCTCCAGC AATTCTTTGTGGTGATGGAGCACTGTCTGAAACATGGCTTGAAAGCTAAAA AAACTTTTCTCGGACAAAATAAATCCTTCTGGGGGCCTCTAGAACTGGTAG AAAAGCTTGTTCCAGAAGCCGCAGAGATAACAGCAAGTGTTAAAGATCTTC CAGGACTTAAGACACCAGTAGGTAGAGGAAGAGCCTGGCTTCGTTTGGCAT TAATGCAAAAGAAACTTTCAGAATATATGAAAGCTTTGATCAATAAGAAAG AACTTCTCAGTGAATTCTACGAACCCAATGCCCTCATGATGGAAGAAGAAG GAGCCATAATTGCTGGTCTGTTGGTGGGTCTGAATGTCATTGATGCCAATTT CTGTATGAAAGGAGAAGACTTGGACTCTCAGGTTGGAGTTATAGATTTTTC AATGTATCTCAAGGACGGGAACAGCAGTAAAGGTACTGAAGGAGACGGTC AGATTACTGCAATTCTGGACCAGAAGAACTATGTAGAAGAACTGAACAGAC ATTTGAATGCTACTGTAAACAACCTTCAGGCAAAAGTAGATGCATTAGAAA AATCCAACACTAAACTGACAGAGGAGCTTGCAGTTGCAAACAACAGGATC ATTACCTTACAAGAAGAAATGGAACGAGTTAAAGAGGAAAGTTCCTACATA CTGGAATCCAATCGGAAGGGTCCCAAGCAAGACAGAACTGCAGAAGGGCA AGCACTAAGTGAAGCAAGAAAGCATTTAAAAGAAGAGACACAATTACGAT TGGATGTTGAGAAAGAACTGGAGATGCAGATCAGCATGAGGCAGGAGATG GAATTGGCTATGAAGATGCTGGAGAAGGATGTCTGTGAGAAGCAGGATGC CCTGGTATCTCTTCGGCAGCAGCTGGATGACCTCAGAGCTCTCAAGCATGA ACTTGCCTTTAAGCTGCAGAGTTCAGACTTAGGAGTAAAACAGAAAAGTGA ACTAAACAGTCGCTTGGAAGAGAAGACTAATCAGATGGCTGCTACCATTAA ACAACTTGAACAAAGATTGCGCCAGGCTGAGCGAAGCCGCCAATCTGCTGA GTTGGACAACCGGCTCTTCAAACAGGACTTTGGAGACAAGATCAACAGTCT GCAGCTGGAAGTCGAGGAGCTCACCAGGCAGCGGAACCAGCTTGAGTTAG AACTAAAACAGGAAAAAGAAAGAAGATTACAAAACGACAGGAGCATCCCA GGAAGGGGTTCCCAGAAGTCAGAATCCAAGATGGATGGGAAGCACAAAAT GCAAGAGGAAAATGTTAAACTAAAAAAGCCCCTGGAAGAAAGCCACAGGC TGCAACCCCACCCTATGGATGAACAGGATCAGCTGCTGCTCTCTGAAAAGC CACAGTTGTGTCAGCTATGCCAGGAAGACGGCAGCCTAACAAAGATGAAA ACTCTGCCGCTGTTTGTGTGCATCTGTGCACTGAGTGCTTGCTTCTCGTTCA GTGAAGGTCGAGAAAGGGATCATGAACTACGTCACAGAAGGCATCATCAC CAATCACCCAAATCTCACTTTGAATTACCACATTATCCTGGACTGCTAGCTC ACCAGAAGCCGTTCATTAGAAAGTCCTATAAATGTCTGCACAAACGCTGTA GGCCTAAGCTTCCACCTTCACCTAATAACCCCCCCAAATTCCCAAATCCTCA CCAGCCACCTAAACATCCAGATAAAAATAGCAGTGTGGTCAACCCTACCTT AGTGGCTACAACCCAAATTCCATCTGTGACTTTCCCATCAGCTTCCACCAAA ATTACTACCCTTCCAAATGTGACTTTTCTTCCCCAGAATGCCACCACCATAT CTTCAAGAGAAAATGTTAACACAAGCTCTTCTGTAGCTACATTAGCACCAG TGAATTCCCCAGCTCCACAAGACACCACAGCTGCCCCACCCACACCTTCTG CAACTACACCAGCTCCACCATCTTCCTCAGCTCCACCAGAGACCACAGCTG CCCCACCCACACCTTCTGCAACTACACAAGCTCCACCATCTTCCTCAGCTCC ACCAGAGACCACAGCTGCCCCACCCACACCTCCTGCAACTACACCAGCTCC ACCATCTTCCTCAGCTCCACCAGAGACCACAGCTGCCCCACCCACACCTTCT GCAACTACACCAGCTCCACTATCTTCCTCAGCTCCACCAGAGACCACAGCT GTCCCACCCACACCTTCTGCAACTACCCTAGACCCATCATCCGCCTCAGCTC CACCAGAGACCACAGCTGCCCCACCCACACCTTCTGCAACTACACCAGCTC CACCGTCTTCCCCAGCTCCACAAGAGACCACAGCTGCCCCAATTACCACAC CTAATTCTTCCCCAACTACTCTTGCACCTGACACTTCTGAAACTTCAGCTGC ACCCACACACCAGACTACTACTTCGGTCACTACTCAAACTACTACTACTAA ACAACCAACTTCAGCTCCTGGCCAAAATAAAATTTCTCGATTTCTTTTATAT ATGAAGAATCTACTAAACAGAATTATTGACGACATGGTGGAGCAATAG LLGL2-> GGAGGTGAGCAGGAAGGAGACGGCCGCCCAGCAGCCCGTGGGCAGGCGCG SEQ ID CPNE4 GCGGAGCGAGCGGGGCCGGCGGCGGGCGCCGAGGGACGCCGAGGCCTCGG NO:91 GCGGGGGCTGGCCCGGGGTTCCAGGTTGACAGGACTGAGGTGATTCGCACC TGCATAAACCCAGTGTACTCAAAACTGTTTACTGTGGACTTTTACTTTGAGG AGGTGCAGCGCCTGCGGTTTGAAGTCCATGACATCAGCAGCAACCACAATG GGCTGAAGGAGGCCGACTTCCTTGGTGGCATGGAGTGCACACTTGGCCAGA TTGTTTCCCAGAGAAAGCTGTCCAAATCCTTGCTGAAGCATGGGAACACAG CAGGGAAATCTTCCATCACGGTGATTGCTGAAGAATTATCTGGCAATGACG ACTATGTTGAGCTTGCATTCAATGCACGGAAATTGGATGACAAGGATTTCTT CAGTAAATCTGACCCATTTCTGGAAATTTTTCGTATGAATGATGATGCAACT CAGCAGCTGGTGCACCGAACTGAGGTTGTGATGAATAACTTAAGCCCAGCC TGGAAATCATTCAAAGTATCTGTAAATTCTCTATGCAGCGGAGACCCAGAC CGCCGGCTAAAGTGCATAGTATGGGACTGGGACTCCAATGGCAAGCATGAC TTCATTGGAGAATTCACCTCGACATTCAAGGAGATGAGAGGAGCAATGGAA GGGAAACAGGTGCAGTGGGAGTGCATCAATCCCAAGTACAAAGCCAAGAA GAAGAATTACAAGAACTCAGGCACTGTGATTCTGAATCTGTGCAAGATTCA CAAGATGCATTCTTTCTTGGACTACATCATGGGTGGCTGCCAAATCCAGTTT ACAGTAGCTATAGATTTCACTGCCTCAAACGGGGACCCCAGGAACAGCTGT TCCTTGCACTACATCCACCCTTACCAACCCAATGAGTATCTGAAAGCTTTGG TAGCTGTGGGGGAGATTTGCCAAGACTATGACAGTGACAAAATGTTCCCTG CCTTTGGGTTTGGCGCCAGGATACCTCCAGAGTACACGGTCTCTCATGACTT TGCAATCAACTTTAATGAAGACAACCCAGAATGTGCAGGAATTCAAGGAGT TGTGGAAGCCTATCAGAGCTGTCTTCCTAAGCTCCAACTCTACGGTCCCACC AACATTGCCCCCATCATCCAGAAGGTTGCCAAGTCAGCGTCAGAGGAAACT AACACCAAGGAGGCATCGCAATACTTCATCCTGCTGATCCTGACAGATGGT GTTATCACAGACATGGCCGACACCCGGGAGGCCATTGTCCATGCCTCCCAC CTCCCCATGTCAGTCATCATCGTGGGAGTAGGGAACGCTGACTTCAGTGAC ATGCAGATGCTGGACGGTGATGATGGGATTCTGAGGTCACCCAAGGGAGA GCCTGTTCTTCGAGACATCGTCCAGTTCGTGCCCTTCAGGAACTTCAAACAC GCATCTCCAGCTGCCCTGGCAAAGAGCGTGCTGGCTGAAGTCCCAAACCAA GTTGTGGACTATTACAATGGCAAAGGAATTAAACCAAAATGTTCATCAGAA ATGTATGAATCTTCCAGAACACTAGCACCATGAACTCCCCACACAGTTTTAC AGAGTTCTGAAATACTATTCCTGCTAATATTTCATATTTAATACTTCTACTA CTCCTGTACTTTAAAAAACCAACAACATATACACATTTAAAAATAGCACGT TTTGGTGATTTTTAACTATCTGACAATTTTTTTTGCATGTGTAGCCCTGAGGC CTGGATCTGTTAAGCCCTTGTATTGTTAACTTTTTACAAAGAAACACAGATA ACAATAACTTACTATTTACATTACAGCATGTCGCCTTGAAATAAAATGGTAT CTGTATCCATTTTTTATACAGGTTTGTTGAAATTTTGCTAAATTTCTTATCTT TACACTCTAAAGCATTTTGAAACATTTACTGAATGTTGATAGACGAAATAT ACTTGGTTTTATCTGCTATAGGATGAGAGACTTTTTAAAATGGCAGATGCAT GGACTGTATTTTGCATGTTTAAAATAA SEMA4C- ATGGCCCCACACTGGGCTGTCTGGCTGCTGGCAGCAAGGCTGTGGGGCCTG SEQ ID > GGCATTGGGGCTGAGGTGTGGTGGAACCTTGTGCCGCGTAAGACAGTGTCT NO:92 BRE TCTGGGGAGCTGGCCACGGTAGTACGGCGGTTCTCCCAGACCGGCATCCAG GACTTCCTGACACTGACGCTGACGGAGCCCACTGGGCTTCTGTACGTGGGC GCCCGAGAGGCCCTGTTTGCCTTCAGCATGGAGGCCCTGGAGCTGCAAGGA GCGATCTCCTGGGAGGCCCCCGTGGAGAAGAAGACTGAGTGTATCCAGAA AGGGAAGAACAACCAGACCGAGTGCTTCAACTTCATCCGCTTCCTGCAGCC CTACAATGCCTCCCACCTGTACGTCTGTGGCACCTACGCCTTCCAGCCCAAG TGCACCTACGTCAACATGCTCACCTTCACTTTGGAGCATGGAGAGTTTGAA GATGGGAAGGGCAAGTGTCCCTATGACCCAGCTAAGGGCCATGCTGGCCTT CTTGTGGATGGTGAGCTGTACTCGGCCACACTCAACAACTTCCTGGGCACG GAACCCATTATCCTGCGTAACATGGGGCCCCACCACTCCATGAAGACAGAG TACCTGGCCTTTTGGCTCAACGAACCTCACTTTGTAGGCTCTGCCTATGTAC CTGAGAGTGTGGGCAGCTTCACGGGGGACGACGACAAGGTCTACTTCTTCT TCAGGGAGCGGGCAGTGGAGTCCGACTGCTATGCCGAGCAGGTGGTGGCTC GTGTGGCCCGTGTCTGCAAGGGCGATATGGGGGGCGCACGGACCCTGCAGA GGAAGTGGACCACGTTCCTGAAGGCGCGGCTGGCATGCTCTGCCCCGAACT GGCAGCTCTACTTCAACCAGCTGCAGGCGATGCACACCCTGCAGGACACCT CCTGGCACAACACCACCTTCTTTGGGGTTTTTCAAGCACAGTGGGGTGACAT GTACCTGTCGGCCATCTGTGAGTACCAGTTGGAAGAGATCCAGCGGGTGTT TGAGGGCCCCTATAAGGAGTACCATGAGGAAGCCCAGAAGTGGGACCGCT ACACTGACCCTGTACCCAGCCCTCGGCCTGGCTCGTGCATTAACAACTGGC ATCGGCGCCACGGCTACACCAGCTCCCTGGAGCTACCCGACAACATCCTCA ACTTCGTCAAGAAGCACCCGCTGATGGAGGAGCAGGTGGGGCCTCGGTGG AGCCGCCCCCTGCTCGTGAAGAAGGGCACCAACTTCACCCACCTGGTGGCC GACCGGGTTACAGGACTTGATGGAGCCACCTATACAGTGCTGTTCATTGGC ACAGGAGACGGCTGGCTGCTCAAGGCTGTGAGCCTGGGGCCCTGGGTTCAC CTGATTGAGGAGCTGCAGCTGTTTGACCAGGAGCCCATGAGAAGCCTGGTG CTATCTCAGAGCAAGAAGCTGCTCTTTGCCGGCTCCCGCTCTCAGCTGGTGC AGCTGCCCGTGGCCGACTGCATGAAGTATCGCTCCTGTGCAGACTGTGTCCT CGCCCGGGACCCCTATTGCGCCTGGAGCGTCAACACCAGCCGCTGTGTGGC CGTGGGTGGCCACTCTGGATCTCTACTGATCCAGCATGTGATGACCTCGGA CACTTCAGGCATCTGCAACCTCCGTGGCAGTAAGAAAGGGCTTATTTCAAA ACCTTTGTCCCTCAGTTCCAGGAGGCAGCATTTGCCAATGGAAAGCTCTAG GAAACACCAGTCTTGAGAGGTGGCCAGCCAGACTGCCTGTCCACATGCGTG TCAGCACATACAGCCGCTTCCTGGAAGCCGCCTGGAATGTCTTCACGGCAG CGTTTTGCTCACACAGCAGCTTTTGCACGCCCCAGGCAGCCCCGACTGCTGA AATCCAACTTGAGCTGGCTGGTGGTCCCTGGATCCTAGAGCCCTTCACTTCG GGTTACTCCCTCTTTCTTGCCTCTATTTCTTAGTTGGAAGAAATAAACTCAC AAATTATGGTGCAGTAATTTTCCGGGGAAAGTAAAGCCTCAGGAATGCCCA CGCCTTTCTTCCAAAGCCTTTGTCTCTGAGACCTCTTAAGTTCTAAGATTAA ATGCCCCTCGCTGTTCTTCCTCTGAAA ESRl-> ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAG SEQ ID AKAP12 ATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCC NO:93 CTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTG TACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCC AACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAG GCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGC GTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCA GCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATT CAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGAC AAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTG TGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCT GCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTC CAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAG GCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGTTGGA CAGAGAGACTCTGAAGATGTGAGCAAAAGAGACTCCGATAAAGAGATGGC TACTAAGTCAGCGGTTGTTCACGACATCACAGATGATGGGCAGGAGGAGAC ACCCGAAATAATCGAACAGATTCCTTCTTCAGAAAGCAATTTAGAAGAGCT AACACAACCCACTGAGTCCCAGGCTAATGATATTGGATTTAAGAAGGTGTT TAAGTTTGTTGGCTTTAAATTCACTGTGAAAAAGGATAAGACAGAGAAGCC TGACACTGTCCAGCTACTCACTGTGAAGAAAGATGAAGGGGAGGGAGCAG CAGGGGCTGGCGACCACAAGGACCCCAGCCTTGGGGCTGGAGAAGCAGCA TCCAAAGAAAGCGAACCCAAACAATCTACAGAGAAACCCGAAGAGACCCT GAAGCGTGAGCAAAGCCACGCAGAAATTTCTCCCCCAGCCGAATCTGGCCA AGCAGTGGAGGAATGCAAAGAGGAAGGAGAAGAGAAACAAGAAAAAGAA CCTAGCAAGTCTGCAGAATCTCCGACTAGTCCCGTGACCAGTGAAACAGGA TCAACCTTCAAAAAATTCTTCACTCAAGGTTGGGCCGGCTGGCGCAAAAAG ACCAGTTTCAGGAAGCCGAAGGAGGATGAAGTGGAAGCTTCAGAGAAGAA AAAGGAACAAGAGCCAGAAAAAGTAGACACAGAAGAAGACGGAAAGGCA GAGGTTGCCTCCGAGAAACTGACCGCCTCCGAGCAAGCCCACCCACAGGA GCCGGCAGAAAGTGCCCACGAGCCCCGGTTATCAGCTGAATATGAGAAAGT TGAGCTGCCCTCAGAGGAGCAAGTCAGTGGCTCGCAGGGACCTTCTGAAGA GAAACCTGCTCCGTTGGCGACAGAAGTGTTTGATGAGAAAATAGAAGTCCA CCAAGAAGAGGTTGTGGCCGAAGTCCACGTCAGCACCGTGGAGGAGAGAA CCGAAGAGCAGAAAACGGAGGTGGAAGAAACAGCAGGGTCTGTGCCAGCT GAAGAATTGGTTGAAATGGATGCAGAACCTCAGGAAGCTGAACCTGCCAA GGAGCTGGTGAAGCTCAAAGAAACGTGTGTTTCCGGAGAGGACCCTACACA GGGAGCTGACCTCAGTCCTGATGAGAAGGTGCTGTCCAAACCCCCCGAAGG CGTTGTGAGTGAGGTGGAAATGCTGTCATCACAGGAGAGAATGAAGGTGC AGGGAAGTCCACTAAAGAAGCTTTTTACCAGCACTGGCTTAAAAAAGCTTT CTGGAAAGAAACAGAAAGGGAAAAGAGGAGGAGGAGACGAGGAATCAGG GGAGCACACTCAGGTTCCAGCCGATTCTCCGGACAGCCAGGAGGAGCAAA AGGGCGAGAGCTCTGCCTCATCCCCTGAGGAGCCCGAGGAGATCACGTGTC TGGAAAAGGGCTTAGCCGAGGTGCAGCAGGATGGGGAAGCTGAAGAAGGA GCTACTTCCGATGGAGAGAAAAAAAGAGAAGGTGTCACTCCCTGGGCATCA TTCAAAAAGATGGTGACGCCCAAGAAGCGTGTTAGACGGCCTTCGGAAAGT GATAAAGAAGATGAGCTGGACAAGGTCAAGAGCGCTACCTTGTCTTCCACC GAGAGCACAGCCTCTGAAATGCAAGAAGAAATGAAAGGGAGCGTGGAAGA GCCAAAGCCGGAAGAACCAAAGCGCAAGGTGGATACCTCAGTATCTTGGG AAGCTTTAATTTGTGTGGGATCATCCAAGAAAAGAGCAAGGAGAGGGTCCT CTTCTGATGAGGAAGGGGGACCAAAAGCAATGGGAGGAGACCACCAGAAA GCTGATGAGGCCGGAAAAGACAAAGAGACGGGGACAGACGGGATCCTTGC TGGTTCCCAAGAACATGATCCAGGGCAGGGAAGTTCCTCCCCGGAGCAAGC TGGAAGCCCTACCGAAGGGGAGGGCGTTTCCACCTGGGAGTCATTTAAAAG GTTAGTCACGCCAAGAAAAAAATCAAAGTCCAAGCTGGAAGAGAAAAGCG AAGACTCCATAGCTGGGTCTGGTGTAGAACATTCCACTCCAGACACTGAAC CCGGTAAAGAAGAATCCTGGGTCTCAATCAAGAAGTTTATTCCTGGACGAA GGAAGAAAAGGCCAGATGGGAAACAAGAACAAGCCCCTGTTGAAGACGCA GGGCCAACAGGGGCCAACGAAGATGACTCTGATGTCCCGGCCGTGGTCCCT CTGTCTGAGTATGATGCTGTAGAAAGGGAGAAAATGGAGGCACAGCAAGC CCAAAAAAGCGCAGAGCAGCCCGAGCAGAAGGCAGCCACTGAGGTGTCCA AGGAGCTCAGCGAGAGTCAGGTTCATATGATGGCAGCAGCTGTCGCTGACG GGACGAGGGCAGCTACCATTATTGAAGAAAGGTCTCCTTCTTGGATATCTG CTTCAGTGACAGAACCTCTTGAACAAGTAGAAGCTGAAGCCGCACTGTTAA CTGAGGAGGTATTGGAAAGAGAAGTAATTGCAGAAGAAGAACCCCCCACG GTTACTGAACCTCTGCCAGAGAACAGAGAGGCCCGGGGCGACACGGTCGTT AGTGAGGCGGAATTGACCCCCGAAGCTGTGACAGCTGCAGAAACTGCAGG GCCATTGGGTGCCGAAGAAGGAACCGAAGCATCTGCTGCTGAAGAGACCA CAGAAATGGTGTCAGCAGTCTCCCAGTTAACCGACTCCCCAGACACCACAG AGGAGGCCACTCCGGTGCAGGAGGTGGAAGGTGGCGTACCTGACATAGAA GAGCAAGAGAGGCGGACTCAAGAGGTCCTCCAGGCAGTGGCAGAAAAAGT GAAAGAGGAATCCCAGCTGCCTGGCACCGGTGGGCCAGAAGATGTGCTTCA GCCTGTGCAGAGAGCAGAGGCAGAAAGACCAGAAGAGCAGGCTGAAGCGT CGGGTCTGAAGAAAGAGACGGATGTAGTGTTGAAAGTAGATGCTCAGGAG GCAAAAACTGAGCCTTTTACACAAGGGAAGGTGGTGGGGCAGACCACCCC AGAAAGCTTTGAAAAAGCTCCTCAAGTCACAGAGAGCATAGAGTCCAGTG AGCTTGTAACCACTTGTCAAGCCGAAACCTTAGCTGGGGTAAAATCACAGG AGATGGTGATGGAACAGGCTATCCCCCCTGACTCGGTGGAAACCCCTACAG ACAGTGAGACTGATGGAAGCACCCCCGTAGCCGACTTTGACGCACCAGGCA CAACCCAGAAAGACGAGATTGTGGAAATCCATGAGGAGAATGAGGTCGCA TCTGGTACCCAGTCAGGGGGCACAGAAGCAGAGGCAGTTCCTGCACAGAA AGAGAGGCCTCCAGCACCTTCCAGTTTTGTGTTCCAGGAAGAAACTAAAGA ACAATCAAAGATGGAAGACACTCTAGAGCATACAGATAAAGAGGTGTCAG TGGAAACTGTATCCATTCTGTCAAAGACTGAGGGGACTCAAGAGGCTGACC AGTATGCTGATGAGAAAACCAAAGACGTACCATTTTTCGAAGGACTTGAGG GGTCTATAGACACAGGCATAACAGTCAGTCGGGAAAAGGTCACTGAAGTTG CCCTTAAAGGTGAAGGGACAGAAGAAGCTGAATGTAAAAAGGATGATGCT CTTGAACTGCAGAGTCACGCTAAGTCTCCTCCATCCCCCGTGGAGAGAGAG ATGGTAGTTCAAGTCGAAAGGGAGAAAACAGAAGCAGAGCCAACCCATGT GAATGAAGAGAAGCTTGAGCACGAAACAGCTGTTACCGTATCTGAAGAGG TCAGTAAGCAGCTCCTCCAGACAGTGAATGTGCCCATCATAGATGGGGCAA AGGAAGTCAGCAGTTTGGAAGGAAGCCCTCCTCCCTGCCTAGGTCAAGAGG AGGCAGTATGCACCAAAATTCAAGTTCAGAGCTCTGAGGCATCATTCACTC TAACAGCGGCTGCAGAGGAGGAAAAGGTCTTAGGAGAAACTGCCAACATT TTAGAAACAGGTGAAACGTTGGAGCCTGCAGGTGCACATTTAGTTCTGGAA GAGAAATCCTCTGAAAAAAATGAAGACTTTGCCGCTCATCCAGGGGAAGAT GCTGTGCCCACAGGGCCCGACTGTCAGGCAAAATCGACACCAGTGATAGTA TCTGCTACTACCAAGAAAGGCTTAAGTTCCGACCTGGAAGGAGAGAAAACC ACATCACTGAAGTGGAAGTCAGATGAAGTCGATGAGCAGGTTGCTTGCCAG GAGGTCAAAGTGAGTGTAGCAATTGAGGATTTAGAGCCTGAAAATGGGATT TTGGAACTTGAGACCAAAAGCAGTAAACTTGTCCAAAACATCATCCAGACA GCCGTTGACCAGTTTGTACGTACAGAAGAAACAGCCACCGAAATGTTGACG TCTGAGTTACAGACACAAGCTCACGTGATAAAAGCTGACAGCCAGGACGCT GGACAGGAAACGGAGAAAGAAGGAGAGGAACCTCAGGCCTCTGCACAGGA TGAAACACCAATTACTTCAGCCAAAGAGGAGTCAGAGTCAACCGCAGTGG GACAAGCACATTCTGATATTTCCAAAGACATGAGTGAAGCCTCAGAAAAGA CCATGACTGTTGAGGTAGAAGGTTCCACTGTAAATGATCAGCAGCTGGAAG AGGTCGTCCTCCCATCTGAGGAAGAGGGAGGTGGAGCTGGAACAAAGTCT GTGCCAGAAGATGATGGTCATGCCTTGTTAGCAGAAAGAATAGAGAAGTCA CTAGTTGAACCGAAAGAAGATGAAAAAGGTGATGATGTTGATGACCCTGA AAACCAGAACTCAGCCCTGGCTGATACTGATGCCTCAGGAGGCTTAACCAA AGAGTCCCCAGATACAAATGGACCAAAACAAAAAGAGAAGGAGGATGCCC AGGAAGTAGAATTGCAGGAAGGAAAAGTGCACAGTGAATCAGATAAAGCG ATCACACCCCAAGCACAGGAGGAGTTACAGAAACAAGAGAGAGAATCTGC AAAGTCAGAACTTACAGAATCTTAA APPBP2- ATGGCGGCCGTGGAACTAGAGTGGATCCCAGAGACTCTCTATAACACCGCC SEQ ID > ATCTCCGCTGTCGTGGACAACTACATCCGCTCCCGCCGAGACATCCGCTCCT NO:94 KIF19 TGCCCGAGAACATCCAGTTTGATGTTTACTACAAGCTTTACCAACAGGGAC GCTTATGTCAACTGGGCAGTGAATTTTGTGAATTGGAAGTTTTTGCTAAAGT ACTGAGAGCTTTGGATAAAAGGTGAAGCAGAACCTCCTGAACGTCTCCTAC CACATCGCCCAGTACACCAGCATCATCGCTGACCTGCGGGGCGAGATCCAG CGACTCAAGCGCAAGATTGATGAGCAGACTGGGCGGGGCCAGGCCCGGGG CCGGCAGGATCGGGGTGACATCCGCCACATCCAAGCTGAGGTCCAGCTGCA CAGCGGGCAGGGTGAGAAGGCTGGCATGGGACAGCTTCGGGAGCAGCTCG CCAGCGCCTTCCAGGAGCAGATGGATGTGCGGAGGCGCCTGCTGGAGCTGG AGAACCGCGCCATGGAGGTCCAGATTGACACCTCCCGACACCTGCTCACCA TCGCCGGCTGGAAGCATGAGAAGTCCCGCCGGGCCCTCAAATGGCGGGAG GAGCAGCGAAAGGAGTGCTACGCTAAGGACGACAGCGAGAAGGACTCAGA CACAGGTGATGACCAACCAGACATCCTGGAGCCACCCGAGGTGGCCGCAG CCCGGGAGAGCATTGCAGCCCTGGTGGACGAGCAGAAGCAACTGCGCAAG CAGAAGCTGGCGCTGGAGCAGCGCTGCCGGGAGCTGCGCGCGCGGGGCCG GCGCCTGGAGGAGACGCTGCCGCGGCGCATCGGCTCCGAGGAGCAGCGCG AGGTGCTCAGCCTGCTGTGCCGCGTGCACGAGCTCGAGGTGGAGAACACCG AGATGCAGTCGCACGCGCTGCTCCGCGACGGTGCGCTCCGCCACCGCCACG AGGCCGTGCGCCGCCTGGAGCAGCACCGCAGTCTCTGCGACGAGATTATCC AGGGCCAGCGGCAGATCATCGACGACTACAACCTGGCCGTCCCGCAGCGCC TGGAAGAGCTCTACGAAGTGTACCTGCGGGAGCTGGAGGAGGGCAGCCTG GAGCAGGCCACCATCATGGACCAAGTGGCCTCCAGGGCCCTGCAGGACAG CTCCTTGCCCAAAATTACCCCAGCAGGAACCTCACTGACCCCAGATTCTGA CCTGGAGAGTGTGAAGACATTGAGCTCTGATGCCCAGCACCTGCAGAACAG CGCCCTCCCTCCCCTCAGCACAGAGAGTGAAGGCCACCACGTGTTCAAGGC TGGTACTGGGGCCTGGCAGGCAAAAAGCTCCTCTGTGCCCACCCCACCTCC CATCCAGCTCGGCAGCCTGGTGACGCAGGAGGCCCCGGCTCAGGACAGCCT GGGCAGCTGGATCAACTCTTCCCCTGACAGCAGTGAGAACCTGTCGGAGAT CCCCTTGTCCCACAAAGAGAGGAAGGAGATCCTGACTGGCACCAAGTGCAT CTGGGTGAAGGCCGCCCGGCGGCGCTCGCGGGCCCTGGGAACCGAGGGGC GACACCTGCTGGCACCCGCGACAGAGCGCAGCAGCCTGTCCCTGCACTCAC TGAGCGAGGGCGACGATGCGCGGCCACCAGGCCCACTGGCCTGCAAGCGG CCGCCCAGCCCCACACTACAGCATGCTGCCAGTGAGGACAACCTGTCCAGC AGCACGGGCGAGGCCCCGTCCCGGGCAGTCGGACATCATGGGGACGGCCC CAGGCCCTGGCTGCGTGGCCAGAAGAAAAGCCTGGGCAAGAAAAGGGAGG AGTCGCTGGAGGCAAAGAGAAGGAAGCGGAGGTCCCGATCCTTCGAGGTC ACCGGGCAAGGGCTCTCCCACCCCAAGACACACCTCCTGGGGCCCCATCAG GCGGAGCGCATCTCGGACCACAGGATGCCAGTGTGCAGGCACCCAGCCCCT GGTATCCGGCATCTGGGAAAGGTCACGCTACCTTTGGCCAAAGTCAAACTC CCTCCAAGCCAGAACACGGGCCCGGGGGACTCCTCACCCCTGGCTGTTCCC CCCAACCCAGGTGGTGGTTCTCGACGGGCTACCCGTGGGCCCCGCCTGCCC CACGGCACAAGCACCCATGGCAAAGATGGATGCTCCCGGCATAACTGA ADAM9- ATGGGGTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGC SEQ ID > TGTTGCTTGGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTTCA NO:95 ANKl ACAGACCTCACATCTTTCTTCTTATGAAATTATAACTCCTTGGAGATTAACT AGAGAAAGAAGAGAAGCCCCTAGGCCCTATTCAAAACAAGTATCTTATGTT ATTCAGGCTGAAGGAAAAGAGCATATTATTCACTTGGAAAGGAACAAAGA CCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAAGGGACTTTA ATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTATGTGG AGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGG ATTGCTGCATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAG CTCTCATTTTGAGCACATCATTTATCGAATGGATGATGTCTACAAAGAGCCT CTGAAATGTGGAGTTTCCAACAAGGATATAGAGAAAGAAACTGCAAAGGA TGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTACTTCGAAGAAGAAGAG CTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTAGACAAGG AAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTGAGAGAAGAGATG ATTCTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAA TTGTGCTAGTTGGACTGGAGATTTGGACCAATGGAAACCTGATCAACATAG TTGGGGGTGCTGGTGATGTGCTGGGGAACTTCGTGCAGTGGCGGGAAAAGT TTCTTATCACACGTCGGAGACATGACAGTGCACAGCTAGTTCTAAAGAAAG GTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACAGTGTGTTCAAGGA GCCACGCAGGCGGGATTAATGTGAAGGGGAACACGGCCCTGCACATCGCT GCTCTAGCCGGGCAGGATGAGGTGGTCCGGGAGCTTGTCAACTATGGAGCC AACGTCAACGCCCAGTCACAGAAAGGTTTTACACCCCTGTACATGGCAGCA CAAGAGAACCACTTGGAAGTGGTTAAGTTTTTACTGGAAAATGGAGCTAAC CAGAATGTAGCCACAGAAGACGGCTTCACGCCTCTGGCGGTAGCCCTGCAG CAGGGCCATGAGAACGTCGTCGCGCACCTCATCAACTACGGCACCAAGGGG AAGGTGCGCCTCCCGGCCCTGCACATCGCGGCCCGCAACGACGACACGCGC ACGGCTGCGGTGCTGCTGCAGAACGACCCCAACCCGGACGTGCTTTCCAAG ACGGGATTCACGCCCCTGCACATTGCGGCTCACTACGAGAACCTCAACGTG GCCCAGTTGCTCCTCAACAGAGGAGCCAGCGTCAATTTCACACCACAGAAC GGCATCACGCCACTGCACATCGCCTCCCGCAGGGGCAACGTGATCATGGTG CGGCTGCTGCTGGATCGGGGAGCCCAGATAGAAACCAAGACCAAGGACGA ATTGACACCTCTCCACTGTGCAGCTCGAAATGGGCACGTGCGAATCTCAGA GATCCTGCTGGACCACGGGGCACCAATCCAAGCCAAAACCAAGAACGGCC TGTCCCCAATTCACATGGCGGCTCAGGGAGACCACCTCGACTGTGTCCGGC TCCTGTTGCAATACGACGCAGAGATAGACGACATCACCCTGGACCACCTGA CCCCACTCCACGTGGCTGCCCACTGTGGACACCACAGGGTGGCTAAGGTCC TTCTGGATAAAGGGGCCAAACCCAACTCCAGAGCCCTGAATGGCTTTACCC CCTTACACATCGCCTGCAAAAAGAACCACGTCCGTGTCATGGAGCTGCTGC TGAAGACGGGAGCCTCGATCGACGCGGTCACCGAGTCTGGCCTGACACCTC TCCACGTGGCCTCCTTCATGGGGCACCTTCCCATCGTGAAGAACCTCCTGCA GCGGGGGGCGTCGCCCAACGTCTCCAACGTGAAAGTGGAGACCCCGCTACA CATGGCAGCCAGAGCCGGGCACACGGAAGTGGCCAAATATTTACTCCAGA ACAAAGCCAAAGTCAATGCCAAGGCCAAGGATGACCAGACCCCACTTCACT GTGCAGCTCGCATCGGCCACACAAACATGGTGAAGCTCCTGCTGGAAAATA ACGCCAACCCCAACCTGGCCACCACCGCCGGGCACACCCCCCTGCACATTG CAGCCCGTGAGGGCCATGTGGAAACAGTCCTGGCCCTTCTGGAAAAGGAAG CATCCCAGGCCTGCATGACCAAGAAAGGATTTACCCCTCTGCACGTGGCGG CCAAGTACGGGAAGGTGCGGGTGGCAGAGCTGCTGCTGGAGCGGGACGCA CACCCGAATGCTGCCGGAAAAAATGGCCTGACCCCCCTGCACGTGGCCGTC CATCACAACAACCTGGACATCGTCAAGCTGCTGCTTCCCCGGGGCGGCTCC CCGCACAGCCCTGCCTGGAATGGCTACACCCCTTTGCACATCGCTGCCAAG CAGAACCAGGTGGAGGTGGCCCGTAGTCTGCTGCAGTATGGGGGCTCAGCA AACGCCGAGTCGGTGCAAGGTGTGACGCCCCTTCACCTGGCCGCCCAGGAG GGCCACGCAGAGATGGTGGCTCTGCTGCTCTCGAAACAAGCCAATGGCAAC CTGGGGAACAAGAGCGGACTCACTCCCCTCCATCTGGTAGCACAAGAAGGC CACGTTCCAGTGGCAGATGTGCTGATCAAACACGGCGTCATGGTGGACGCC ACCACCCGGATGGGCTACACTCCCCTCCATGTGGCCAGTCACTATGGAAAC ATCAAGCTGGTGAAGTTTCTGCTGCAGCACCAGGCAGATGTCAATGCCAAG ACCAAGCTAGGATACAGCCCCCTGCACCAGGCAGCCCAGCAGGGACACAC AGACATCGTGACTCTGCTTCTGAAAAACGGTGCTTCCCCAAACGAGGTCAG CTCGGATGGAACCACACCTCTGGCCATAGCCAAGCGCTTGGGCTACATTTC TGTCACCGACGTGCTCAAGGTCGTCACGGATGAAACCAGTTTCGTGTTAGT CAGTGATAAGCATCGAATGAGTTTCCCTGAGACAGTTGATGAGATCCTGGA TGTCTCGGAAGATGAAGGGGAAGAACTCATCAGCTTCAAGGCTGAGAGGC GGGATTCCAGGGATGTTGATGAAGAGAAGGAGCTGCTGGATTTTGTGCCGA AGCTAGACCAAGTGGTGGAATCTCCAGCCATCCCCAGGATTCCCTGTGCCA TGCCTGAGACAGTGGTGATCAGGTCAGAAGAGCAGGAGCAGGCATCTAAA GAGTATGATGAGGACTCCCTCATCCCCAGCAGCCCGGCCACCGAGACCTCA GACAACATCAGCCCGGTGGCCAGCCCGGTGCATACAGGGTTTCTGGTGAGC TTCATGGTTGACGCCCGGGGTGGTTCCATGAGAGGAAGTCGCCACAACGGC CTGCGAGTGGTGATCCCGCCACGGACGTGCGCAGCGCCCACCCGCATCACC TGCCGCCTGGTCAAGCCCCAGAAGCTCAGCACGCCGCCCCCACTGGCCGAG GAGGAGGGCCTGGCCAGCAGGATCATAGCACTGGGGCCCACGGGGGCACA GTTCCTGAGCCCTGTAATCGTGGAGATCCCGCACTTTGCCTCCCATGGCCGT GGAGACCGCGAGCTCGTGGTTCTGAGGAGCGAAAACGGCTCCGTGTGGAA GGAGCACAGGAGCCGCTATGGAGAGAGCTACCTGGATCAGATCCTCAACG GGATGGACGAAGAGCTGGGGAGCCTGGAGGAGCTAGAGAAGAAGAGGGT GTGCCGAATCATCACCACCGACTTCCCGCTGTACTTCGTGATCATGTCACGG CTCTGCCAGGACTACGACACCATCGGTCCCGAAGGGGGCTCCCTGAAGAGC AAGCTGGTGCCCCTGGTACAGGCAACGTTCCCGGAGAATGCCGTCACCAAG AGAGTGAAGCTGGCTCTGCAGGCCCAGCCTGTCCCGGATGAGCTTGTCACT AAGCTCCTGGGCAACCAGGCCACATTCAGCCCCATTGTCACCGTGGAGCCC CGGCGCCGGAAGTTCCACCGCCCCATTGGGCTTCGGATCCCACTACCTCCTT CCTGGACCGACAACCCGAGGGACAGCGGGGAGGGAGACACCACCAGCCTG CGCCTGCTTTGCAGCGTCATTGGAGGAACAGACCAAGCCCAGTGGGAAGAC ATAACAGGAACCACCAAACTTGTATATGCCAACGAGTGCGCCAACTTCACC ACCAATGTCTCTGCCAGGTTTTGGCTGTCGGACTGTCCTCGGACTGCTGAGG CTGTGAACTTTGCCACCCTGCTGTACAAAGAGCTCACTGCAGTGCCCTACAT GGCCAAATTCGTCATCTTTGCCAAGATGAATGACCCCCGAGAGGGGCGCCT GCGCTGCTACTGCATGACAGATGATAAAGTGGACAAGACCCTGGAGCAGC ATGAGAACTTCGTGGAGGTGGCCCGGAGCAGGGACATAGAGGTGTTGGAA GGAATGTCCCTGTTTGCAGAACTCTCTGGGAACCTGGTGCCTGTGAAGAAA GCTGCCCAGCAGCGGAGCTTCCACTTCCAGTCATTTCGGGAGAACCGTCTG GCCATGCCTGTAAAGGTGAGGGACAGCAGTCGAGAGCCGGGAGGGTCCCT GTCGTTTCTGCGCAAGGCGATGAAGTACGAGGACACCCAGCACATTCTCTG CCACCTGAACATCACCATGCCCCCCTGCGCCAAGGGAAGTGGAGCCGAAG ATAGGAGAAGGACCCCGACGCCCCTGGCCCTGCGATACAGCATTCTCAGTG AGTCCACACCAGGTTCTCTCAGTGGGACAGAGCAGGCAGAGATGAAGATG GCTGTTATCTCAGAGCACCTCGGTCTCAGCTGGGCAGAGTTGGCCCGGGAG CTGCAGTTCAGTGTGGAAGACATCAACAGGATCCGAGTGGAAAATCCCAAC TCCCTGTTGGAGCAGAGTGTGGCCTTGCTGAACCTCTGGGTCATCCGTGAA GGCCAAAACGCAAACATGGAGAATCTGTACACAGCCCTGCAGAGCATTGA CCGTGGCGAGATCGTGAACATGCTGGAGGGTTCCGGCCGACAGAGCCGCA ACTTGAAGCCAGACAGGCGGCACACCGACCGCGACTACTCGCTGTCACCCT CCCAGATGAATGGTTACTCCTCACTGCAGGACGAGCTGCTGTCCCCTGCCTC CCTGGGCTGTGCACTTTCCTCTCCGCTACGTGCAGACCAGTACTGGAATGAG GTGGCCGTCCTAGACGCCATCCCCTTGGCGGCCACGGAGCATGACACCATG CTGGAGATGTCTGACATGCAGGTGTGGTCTGCGGGCCTCACGCCTTCTCTGG TCACTGCTGAGGACTCCTCTCTGGAGTGTAGCAAGGCTGAGGACTCTGATG CCACAGGTCACGAGTGGAAGTTGGAGGGGGCACTCTCAGAGGAACCGCGG GGCCCCGAGTTGGGCTCTCTGGAACTTGTGGAGGACGACACAGTGGATTCA GATGCCACAAATGGCCTTATCGATTTGCTTGAACAGGAGGAAGGTCAGAGG TCAGAAGAGAAGCTGCCAGGTTCTAAGAGGCAGGATGACGCGACAGGTGC AGGGCAGGACTCAGAGAATGAAGTGTCTCTTGTTTCAGGCCATCAGAGGGG GCAAGCCCGAATCACACATTCCCCCACCGTGAGTCAGGTGACGGAGAGGA GTCAGGACAGACTGCAGGACTGGGATGCAGACGGCTCGATTGTCTCATACC TGCAAGATGCTGCACAAGGTTCCTGGCAAGAGGAGGTCACGCAAGGTCCAC ACTCATTCCAGGGAACAAGTACCATGACTGAAGGGCTAGAGCCCGGTGGAT CTCAGGAGTACGAGAAGGTCCTGGTGTCTGTAAGTGAGCACACGTGGACAG AACAGCCCGAGGCTGAGAGCTCCCAGGCCGACAGGGACCGGAGGCAGCAA GGCCAAGAAGAGCAGGTGCAGGAGGCCAAGAACACCTTCACCCAAGTGGT GCAGGGGAATGAGTTTCAGAATATTCCAGGGGAGCAGGTGACAGAGGAGC AATTCACGGATGAGCAGGGCAACATTGTCACCAAGAAGATCATTCGCAAGG TGGTTCGACAGATAGACTTGTCCAGCGCCGATGCCGCCCAGGAGCACGAGG AGGTGGAGCTGAGAGGGAGTGGCCTACAGCCGGACCTGATAGAGGGCAGG AAGGGGGCGCAGATAGTGAAGCGGGCCAGCCTGAAAAGGGGGAAACAGTG A MY018A ATGTTTAACCTAATGAAGAAAGACAAGGACAAAGATGGCGGGCGGAAGGA SEQ ID -> GAAGAAGGAGAAAAAGGAGAAAAAGGAGCGGATGTCAGCGGCAGAGCTT NO:96 SSH2 CGGAGCCTGGAGGAGATGAGCCTGCGACGTGGCTTCTTCAACCTGAACCGC TCCTCCAAGCGTGAATCCAAGACGCGCCTGGAAATCTCCAACCCCATCCCC ATCAAGGTGGCCAGCGGCTCTGACCTGCACCTGACTGACATTGACTCCGAT AGTAACCGGGGCAGCGTCATCCTGGACTCGGGCCACCTAAGTACAGCCAGC TCCAGCGATGACCTCAAGGGTGAGGAGGGTAGCTTCCGTGGCTCGGTGCTG CAGCGGGCAGCCAAGTTCGGCTCACTGGCCAAGCAGAACTCACAGATGATT GTCAAGCGCTTTTCCTTCTCCCAGCGTAGCCGGGATGAGAGCGCCTCAGAA ACCTCGACGCCCTCAGAGCACTCTGCCGCCCCCTCGCCACAGGTGGAGGTG AGGACTCTAGAGGGACAGCTGGTGCAGCATCCTGGCCCAGGCATCCCTCGA CCAGGGCACCGATCCCGAGCCCCTGAGCTAGTGACTAAAAAGTTCCCAGTC GACCTGCGCCTGCCCCCCGTGGTGCCCCTGCCCCCACCTACCCTCCGGGAG CTGGAGCTGCAACGACGGCCCACTGGAGACTTTGGCTTCTCCCTGCGGCGC ACAACCATGCTGGATCGGGGCCCCGAGGGCCAGGCCTGTCGGCGTGTGGTC CACTTTGCTGAGCCTGGTGCAGGCACCAAGGACCTGGCCCTGGGGCTGGTG CCAGGAGATCGACTGGTGGAGATTAATGGGCACAATGTGGAGAGCAAGTC CAGGGATGAGATTGTGGAGATGATCCGGCAGTCAGGGGACAGCGTGCGGC TCAAGGTGCAGCCCATTCCAGAGCTCAGCGAGCTCAGCAGGAGCTGGCTGC GGAGCGGCGAGGGACCTCGCAGGGAGCCATCCGATGAGGCAGACAGTGGG GAGGAAGAATGCCGGTCACAGCCCAGGAGCATCAGCGAGAGCTTTCTAACT GTCAAAGGTGCTGCCCTTTTTCTACCACGGGGAAATGGCTCATCCACACCA AGAATCAGCCACAGACGGAACAAGCATGCAGGCGATCTCCAACAGCATCT CCAAGCAATGTTCATTTTACTCCGCCCAGAAGACAACATCAGGCTGGCTGT AAGACTGGAAAGTACTTACCAGAATCGAACACGCTATATGGTAGTGGTTTC AACTAATGGTAGACAAGACACTGAAGAAAGCATCGTCCTAGGAATGGATTT CTCCTCTAATGACAGTAGCACTTGTACCATGGGCTTAGTTTTGCCTCTCTGG AGCGACACGCTAATTCATTTGGATGGTGATGGTGGGTTCAGTGTATCGACG GATAACAGAGTTCACATATTCAAACCTGTATCTGTGCAGGCAATGTGGTCT GCACTACAGAGCTTACACAAGGCTTGTGAAGTCGCCAGAGCGCATAACTAC TACCCAGGCAGCCTATTTCTCACTTGGGTGAGTTATTATGAGAGCCATATCA ACTCAGATCAATCCTCAGTCAATGAATGGAATGCAATGCAAGATGTACAGT CCCACCGGCCCGACTCTCCAGCTCTCTTCACCGACATACCTACTGAACGTGA ACGAACAGAAAGGCTAATTAAAACCAAATTAAGGGAGATCATGATGCAGA AGGATTTGGAGAATATTACATCCAAAGAGATAAGAACAGAGTTGGAAATG CAAATGGTGTGCAACTTGCGGGAATTCAAGGAATTTATAGACAATGAAATG ATAGTGATCCTTGGTCAAATGGATAGCCCTACACAGATATTTGAGCATGTG TTCCTGGGCTCAGAATGGAATGCCTCCAACTTAGAGGACTTACAGAACCGA GGGGTACGGTATATCTTGAATGTCACTCGAGAGATAGATAACTTCTTCCCA GGAGTCTTTGAGTATCATAACATTCGGGTATATGATGAAGAGGCAACGGAT CTCCTGGCGTACTGGAATGACACTTACAAATTCATCTCTAAAGCAAAGAAA CATGGATCTAAATGCCTTGTGCACTGCAAAATGGGGGTGAGTCGCTCAGCC TCCACCGTGATTGCCTATGCAATGAAGGAATATGGCTGGAATCTGGACCGA GCCTATGACTATGTGAAAGAAAGACGAACGGTAACCAAGCCCAACCCAAG CTTCATGAGACAACTGGAAGAGTATCAGGGGATCTTGCTGGCAAGCAAACA GCGGCATAACAAACTATGGAGATCTCATTCAGATAGTGACCTCTCAGACCA CCACGAACCCATCTGCAAACCTGGGCTAGAACTCAACAAGAAGGATATCAC CACCTCAGCAGACCAGATTGCTGAGGTGAAGACCATGGAGAGTCACCCACC CATACCTCCTGTCTTTGTGGAACATATGGTCCCACAAGATGCAAATCAGAA AGGCCTGTGTACCAAAGAAAGAATGATCTGCTTGGAGTTTACTTCTAGGGA ATTTCATGCTGGACAGATTGAGGATGAATTAAACTTAAATGACATCAATGG ATGCTCATCAGGGTGTTGTCTGAATGAATCAAAATTTCCTCTTGACAATTGC CATGCATCCAAAGCCTTAATTCAGCCTGGACATGTCCCAGAAATGGCCAAC AAGTTTCCAGACTTAACAGTGGAAGATTTGGAGACAGATGCACTGAAAGCA GACATGAATGTCCACCTACTGCCTATGGAAGAATTGACATCTCCACTGAAA GACCCCCCCATGTCCCCTGATCCTGAGTCACCAAGCCCCCAACCCAGTTGC CAGACTGAAATCTCAGATTTCAGTACAGATCGCATTGACTTTTTTAGTGCCC TAGAGAAGTTTGTGGAGCTCTCCCAAGAAACCCGGTCACGATCTTTTTCCCA TTCAAGGATGGAGGAACTGGGTGGAGGAAGGAATGAGAGCTGTCGACTGT CAGTGGTAGAAGTAGCCCCTTCCAAAGTGACAGCTGATGACCAGAGAAGC AGCTCTTTGAGTAATACTCCCCATGCATCAGAAGAATCTTCAATGGATGAG GAACAGTCAAAGGCAATTTCAGAACTGGTCAGCCCAGACATCTTCATGCAG TCTCACTCGGAAAATGCAATTTCAGTCAAAGAAATTGTCACTGAAATTGAG TCCATCAGTCAAGGAGTTGGGCAGATTCAACTGAAAGGAGACATCTTACCC AACCCATGCCATACACCAAAGAAGAACAGCATCCATGAGCTGCTCCTTGAG AGGGCCCAGACTCCAGAGAACAAACCTGGACATATGGAGCAAGATGAGGA CTCCTGCACAGCCCAGCCTGAACTAGCCAAAGACTCAGGGATGTGCAACCC AGAAGGCTGCCTAACCACACACTCATCTATAGCAGACTTGGAAGAAGGGG AACCAGCTGAGGGGGAACAAGAGCTCCAGGGCTCAGGGATGCACCCAGGT GCCAAGTGGTACCCTGGGTCTGTGAGGCGAGCCACCTTGGAGTTCGAAGAG CGCTTACGGCAGGAGCAAGAGCATCATGGTGCTGCCCCAACATGTACCTCA TTGTCCACTCGTAAGAATTCAAAGAATGATTCTTCTGTGGCAGACCTAGCAC CAAAAGGGAAAAGTGATGAAGCCCCCCCAGAACATTCATTTGTCCTCAAGG AACCAGAAATGAGCAAAGGCAAAGGGAAATACAGTGGGTCTGAGGCTGGC TCACTGTCCCATTCTGAGCAGAATGCCACTGTTCCAGCTCCCAGGGTGCTGG AGTTTGACCACTTGCCAGATCCTCAGGAGGGCCCAGGGTCAGATACTGGAA CACAGCAGGAAGGAGTCCTGAAGGATCTGAGGACTGTGATTCCATACCAGG AGTCTGAAACACAAGCAGTCCCTCTTCCCCTTCCCAAGAGGGTAGAAATCA TTGAATATACCCACATAGTTACATCACCCAATCACACTGGGCCAGGGAGTG AAATAGCCACCAGTGAGAAGAGCGGAGAGCAAGGGCTGAGGAAAGTGAAC ATGGAAAAATCTGTCACTGTGCTCTGCACACTGGATGAAAATCTAAACAGG ACTCTGGACCCCAACCAGGTTTCTCTGCACCCCCAAGTGCTACCTCTGCCTC ATTCTTCCTCCCCTGAGCACAACAGACCCACTGACCATCCAACCTCCATCCT GAGTAGCCCTGAAGACAGAGGCAGCAGCCTGTCCACAGCCCTGGAGACAG CAGCACCTTTTGTCAGTCATACAACCCATTTACTGTCTGCCAGTTTGGATTA CCTGCATCCCCAGACTATGGTTCACCTGGAGGGCTTCACAGAGCAGAGCAG CACTACAGATGAGCCCTCTGCAGAACAGGTTAGCTGGGAAGAAAGTCAGG AGAGCCCTCTCTCCAGTGGCAGTGAGGTGCCATATAAGGACTCCCAGCTAA GTAGCGCAGACCTAAGTTTAATTAGCAAACTTGGTGACAACACTGGGGAGT TACAGGAGAAAATGGACCCATTGCCTGTAGCCTGTCGACTCCCACATAGCT CTAGTAGTGAAAACATAAAGAGTCTCAGCCACAGCCCCGGTGTGGTGAAGG AGCGTGCTAAAGAAATCGAGTCTCGAGTGGTTTTCCAGGCAGGGCTCACCA AACCATCCCAAATGAGGCGCTCAGCTTCTCTCGCCAAATTAGGTTACTTGG ACCTCTGTAAAGACTGCTTACCAGAGAGGGAGCCTGCCTCCTGTGAATCCC CTCATCTCAAACTGCTTCAGCCTTTCCTCAGAACAGACTCAGGCATGCACGC GATGGAGGACCAAGAGTCCCTAGAAAACCCAGGTGCCCCCCACAACCCAG AGCCCACCAAGTCTTTTGTAGAACAACTCACAACAACAGAGTGTATTGTGC AGAGCAAGCCAGTGGAGAGGCCCCTTGTGCAGTATGCCAAAGAATTTGGTT CTAGTCAGCAGTATTTGCTCCCCAGGGCAGGACTTGAATTGACTAGTTCTGA AGGAGGCCTTCCCGTGCTACAGACCCAGGGACTGCAGTGTGCATGCCCAGC TCCAGGGCTGGCCGTGGCACCCCGTCAGCAACACGGCAGAACTCACCCCCT TAGGAGACTGAAAAAGGCAAATGACAAAAAACGGACAACCAACCCCTTCT ATAATACCATGTGA PLEKHA ATGGAGGGGGTGCTGTACAAGTGGACCAACTATCTGAGCGGTTGGCAGCCT SEQ ID 8-> CGATGGTTCCTTCTCTGTGGGGGAATATTGTCCTATTATGATTCTCCTGAAG NO:97 GNAQ ATGCCTGGAAAGGTTGCAAAGGGAGCATACAAATGGCAGTCTGTGAAATTC AAGTTCATTCTGTAGATAATACACGCATGGACCTGATAATCCCTGGGGAAC AGTATTTCTACCTGAAGGCCAGAAGTGTGGCTGAAAGACAGCGGTGGCTGG TGGCCCTGGGATCAGCCAAGGCTTGCCTGACTGACAGTAGGACCCAGAAGG AGAAAGAGTTTGCTGAAAACACTGAAAACTTGAAAACCAAAATGTCAGAA CTAAGACTCTACTGTGACCTCCTTGTTCAGCAAGTAGATAAAACAAAAGAA GTGACCACAACTGGTGTGTCCAATTCTGAGGAGGGAATTGATGTGGGAACT TTGCTGAAATCAACCTGTAATACTTTTCTGAAGACCTTGGAAGAATGCATGC AGATCGCAAATGCAGCCTTCACCTCTGAGCTGCTCTACCGCACTCCACCAG GATCACCTCAGCTGGCCATGCTCAAGTCCAGCAAGATGAAACATCCTATTA TACCAATTCATAATTCATTGGAAAGGCAAATGGAGTTGAGCACTTGTGAAA ATGGATCTTTAAATATGGAAATAAATGGTGAGGAAGAAATCCTAATGAAAA ATAAGAATTCCTTATATTTGAAATCTGCAGAGATAGACTGCAGCATATCAA GTGAGGAAAATACAGATGATAATATAACAGTCCAAGGTGAAATAAGGAAG GAAGATGGAATGGAAAACCTGAAAAATCATGACAATAACTTGACTCAGTCT GGATCAGACTCAAGTTGCTCTCCGGAATGCCTCTGGGAGGAAGGCAAAGAA GTTATCCCAACTTTCTTTAGTACCATGAACACAAGCTTTAGTGACATTGAAC TTCTGGAAGACAGTGGCATTCCCACAGAAGCATTCTTGGCATCATGTTATGC TGTGGTTCCAGTATTAGACAAACTTGGCCCTACAGTGTTTGCTCCTGTTAAG ATGGATCTTGTTGGAAATATTAAGAAAGTAAATCAGAAGTATATAACCAAC AAAGAAGAGTTTACCACTCTCCAGAAGATAGTGCTGCACGAAGTGGAGGC GGATGTAGCCCAGGTTAGGAACTCAGCGACTGAAGCCCTCTTGTGGCTGAA GAGAGGTCTCAAATTTTTGAAGGGATTTTTGACAGAAGTGAAAAATGGGGA GAAGGATATCCAGACAGCCCTAAATAATGCATATGGTAAAACATTGCGGCA ACACCATGGCTGGGTAGTTCGAGGGGTTTTTGCGGGACAGGAGAGAGTGGC AAGAGTACGTTTATCAAGCAGATGAGAATCATCCATGGGTCAGGATACTCT GATGAAGATAAAAGGGGCTTCACCAAGCTGGTGTATCAGAACATCTTCACG GCCATGCAGGCCATGATCAGAGCCATGGACACACTCAAGATCCCATACAAG TATGAGCACAATAAGGCTCATGCACAATTAGTTCGAGAAGTTGATGTGGAG AAGGTGTCTGCTTTTGAGAATCCATATGTAGATGCAATAAAGAGTTTATGG AATGATCCTGGAATCCAGGAATGCTATGATAGACGACGAGAATATCAATTA TCTGACTCTACCAAATACTATCTTAATGACTTGGACCGCGTAGCTGACCCTG CCTACCTGCCTACGCAACAAGATGTGCTTAGAGTTCGAGTCCCCACCACAG GGATCATCGAATACCCCTTTGACTTACAAAGTGTCATTTTCAGAATGGTCGA TGTAGGGGGCCAAAGGTCAGAGAGAAGAAAATGGATACACTGCTTTGAAA ATGTCACCTCTATCATGTTTCTAGTAGCGCTTAGTGAATATGATCAAGTTCT CGTGGAGTCAGACAATGAGAACCGAATGGAGGAAAGCAAGGCTCTCTTTA GAACAATTATCACATACCCCTGGTTCCAGAACTCCTCGGTTATTCTGTTCTT AAACAAGAAAGATCTTCTAGAGGAGAAAATCATGTATTCCCATCTAGTCGA CTACTTCCCAGAATATGATGGACCCCAGAGAGATGCCCAGGCAGCCCGAGA ATTCATTCTGAAGATGTTCGTGGACCTGAACCCAGACAGTGACAAAATTAT CTACTCCCACTTCACGTGCGCCACAGACACCGAGAATATCCGCTTTGTCTTT GCTGCCGTCAAGGACACCATCCTCCAGTTGAACCTGAAGGAGTACAATCTG GTCTAA FBXL20- ATGAGGAGGGACGTGAACGGAGTGACCAAGAGCAGGTTTGAGATGTTCTC SEQ ID > AAATAGTGATGAAGCTGTAATCAATAAAAAACTTCCCAAAGAACTCCTGTT NO:98 NSF ACGGATATTTTCTTTTCTAGATGTTGTTACCCTGTGCCGCTGTGCTCAGGTCT CCAGGGCCTGGAATGTTCTGGCTCTGGATGGCAGTAACTGGCAGCGAATTG ACCTATTTGATTTCCAGAGGGATATTGAGGGCCGAGTAGTGGAGAATATTT CAAAACGATGTGGGGGCTTTTTACGAAAGTTAAGTCTTCGTGGATGTCTTG GAGTGGGAGACAATGCATTAAGAACCTTTGCACAAAACTGCAGGAACATTG AAGTACTGAATCTAAATGGGTGTACAAAGACAACAGACGCGTTGTAAACAT GTTAAAGGCATCCTGTTATATGGACCCCCAGGTTGTGGTAAGACTCTCTTGG CTCGACAGATTGGCAAGATGTTGAATGCAAGAGAGCCCAAAGTGGTCAATG GGCCAGAAATCCTTAACAAATATGTGGGAGAATCAGAGGCTAACATTCGCA AACTTTTTGCTGATGCTGAAGAGGAGCAAAGGAGGCTTGGTGCTAACAGTG GTTTGCACATCATCATCTTTGATGAAATTGATGCCATCTGCAAGCAGAGAG GGAGCATGGCTGGTAGCACGGGAGTTCATGACACTGTTGTCAACCAGTTGC TGTCCAAAATTGATGGCGTGGAGCAGCTAAACAACATCCTAGTCATTGGAA TGACCAATAGACCAGATCTGATAGATGAGGCTCTTCTTAGACCTGGAAGAC TGGAAGTTAAAATGGAGATAGGCTTGCCAGATGAGAAAGGCCGACTACAG ATTCTTCACATCCACACAGCAAGAATGAGAGGGCATCAGTTACTCTCTGCT GATGTAGACATTAAAGAACTGGCCGTGGAGACCAAGAATTTCAGTGGTGCT GAATTGGAGGGTCTGGTGCGAGCAGCCCAGTCCACTGCTATGAATAGACAC ATAAAGGCCAGTACTAAAGTGGAAGTGGACATGGAGAAAGCAGAAAGCCT GCAAGTGACGAGAGGAGACTTCCTTGCTTCTTTGGAGAATGATATCAAACC AGCCTTTGGCACAAACCAAGAAGATTATGCAAGTTACATTATGAACGGTAT CATCAAATGGGGTGACCCAGTTACTCGAGTTCTAGATGATGGGGAGCTGCT GGTGCAGCAGACTAAGAACAGTGACCGCACACCATTGGTCAGCGTGCTTCT GGAAGGCCCTCCTCACAGTGGGAAGACTGCTTTAGCTGCAAAAATTGCAGA GGAATCCAACTTCCCGTTCATCAAGATCTGTTCTCCTGATAAAATGATTGGC TTTTCTGAAACAGCCAAATGTCAGGCCATGAAGAAGATCTTTGATGATGCG TACAAATCCCAGCTCAGTTGTGTGGTTGTGGATGACATTGAGAGATTGCTTG ATTACGTCCCTATTGGCCCTCGATTTTCAAATCTTGTATTACAGGCTCTTCTC GTTTTACTGAAAAAGGCACCTCCTCAGGGCCGCAAGCTTCTTATCATTGGG ACCACTAGCCGCAAAGATGTCCTTCAGGAGATGGAAATGCTTAACGCTTTC AGCACCACCATCCACGTGCCCAACATTGCCACAGGAGAGCAGCTGTTGGAA GCTTTGGAGCTTTTGGGCAACTTCAAGGATAAGGAACGCACCACAATTGCA CAGCAAGTCAAAGGGAAGAAGGTCTGGATAGGAATCAAGAAGTTACTAAT GCTGATCGAGATGTCCCTACAGATGGATCCTGAATACCGTGTGAGAAAATT CTTGGCCCTCTTAAGAGAAGAAGGAGCTAGCCCCCTTGATTTTGATTGA TRIM37- ATGGATGAACAGAGCGTGGAGAGCATTGCTGAGGTTTTCCGATGTTTCATT SEQ ID > TGTATGGAGAAATTGCGGGATGCACGCCTGTGTCCTCATTGCTCCAAACTGT NO:99 BCAS3 GTTGTTTCAGCTGTATTAGGCGCTGGCTGACAGAGCAGAGAGCTCAATGTC CTCATTGCCGTGCTCCACTCCAGCTACGAGAACTAGTAAATTGTCGTTGGGC AGAAGAAGTAACACAACAGCTTGATACTCTTCAACTCTGCAGTCTCACCAA ACATGAAGAAAATGAAAAGGACAAATGTGAAAATCACCATGAAAAACTTA GTGTATTTTGCTGGACTTGTAAGAAGTGTATCTGCCATCAGTGTGCACTTTG GGGAGGAATGCATGGCGGACATACCTTTAAACCTTTGGCAGAAATTTATGA GCAACACGTCACTAAAGTGAATGAAGAGGTAGCCAAACTTCGTCGGCGTCT CATGGAACTGATCAGCTTAGTTCAAGAAGTGGAAAGGAATGTAGAAGCTGT AAGAAATGCAAAAGATGAGCGTGTTCGGGAAATTAGGAATGCAGTGGAGA TGATGATTGCACGGTTAGACACACAGCTGAAGAATAAGCTTATAACACTGA TGGGTCAGAAGACATCTCTAACCCAAGAAACAGAGCTTTTGGAATCCTTAC TTCAGGAGGTGGAGCACCAGTTGCGGTCTTGTAGTAAGAGTGAGTTGATAT CTAAGAGCTCAGAGATCCTTATGATGTTTCAGCAAGTTCATCGGAAGCCCA TGGCATCTTTTGTTACCACTCCTGTTCCACCAGACTTTACCAGTGAATTAGT GCCATCTTACGATTCAGCTACTTTTGTTTTAGAGAATTTCAGCACTTTGCGT CAGAGAGCAGATCCTGTTTACAGTCCACCTCTTCAAGTTTCAGGACTTTGCT GGAGGTTAAAAGTTTACCCAGATGGAAATGGAGTTGTGCGAGGTTACTACT TATCTGTGTTTCTGGAGCTCTCAGCTGGCTTGCCTGAAACTTCTAAATATGA ATATCGTGTAGAGATGGTTCACCAGTCCTGTAATGATCCTACAAAAAATAT CATTCGAGAATTTGCATCTGACTTTGAAGTTGGAGAATGCTGGGGCTATAA TAGATTTTTCCGTTTGGACTTACTCGCAAATGAAGGATACTTGAATCCACAA AATGATACAGTGATTTTAAGGTTTCAGGTACGTTCACCAACTTTCTTTCAAA AATCCCGGGACCAGCATTGGTACATTACTCAGTTGGAAGCTGCACAGACTA GTTATATCCAACAAATAAACAACCTTAAAGAGAGACTTACTATTGAGCTGT CTCGAACTCAGAAGTCAAGAGATTTGTCACCACCAGATAACCATCTTAGCC CCCAAAATGATGATGCTCTGGAGACACGAGCTAAGAAGTCTGCATGCTCTG ACATGCTTCTCGAAGGTGGTCCTACTACAGCTTCTGTAAGAGAGGCCAAAG AGGATGAAGAAGATGAGGAGAAGATTCAGAATGAAGATTATCATCACGAG CTTTCAGATGGAGATCTGGATCTGGATCTTGTTTATGAGGATGAAGTAAATC AGCTCGATGGCAGCAGTTCCTCTGCTAGTTCCACAGCAACAAGTAATACAG AAGAAAATGATATTGATGAAGAAACTATGTCTGGAGAAAATGATGTGGAA TATAACAACATGGAATTAGAAGAGGGAGAACTCATGGAAGATGCAGCTGC TGCAGGACCCGCAGGTAGTAGCCATGGTTATGTGGGTTCCAGTAGTAGAAT ATCAAGAAGAACACATTTATGCTCCGCTGCTACCAGTAGTTTACTAGACATT GATCCATTAATTTTAATACATTTGTTGGACCTTAAGGACCGGAGCAGTATAG AAAATTTGTGGGGCTTACAGCCTCGCCCACCTGCTTCACTTCTGCAGCCCAC AGCATCATATTCTCGAAAAGATAAAGACCAAAGGAAGCAACAGGCAATGT GGCGAGTGCCCTCTGATTTAAAGATGCTAAAAAGACTCAAAACTCAAATGG CCGAAGTTCGATGTATGAAAACTGATGTAAAGAATACACTTTCAGAAATAA AAAGCAGCAGTGCTGCTTCTGGAGACATGCAGACAAGCCTTTTTTCTGCTG ACCAGGCAGCTCTGGCTGCATGTGGAACTGAAAACTCTGGCAGATTGCAGG ATTTGGGAATGGAACTCCTGGCAAAGTCATCAGTTGCCAATTGTTACATAC GAAACTCCACAAATAAGAAGAGTAATTCGCCCAAGCCAGCTCGATCCAGTG TAGCAGGTAGTCTATCACTTCGAAGAGCAGTGGACCCTGGAGAAAATAGTC GTTCAAAGGGAGACTGTCAGACTCTGTCTGAAGATACATCAAGAAATCTGG AATTTCATGAAATACATAGTACTGGGAATGAACCGCCTTTGTTGATTATGAT TGGCTACAGTGATGGAATGCAGGTCTGGAGCATCCCTATCAGTGGTGAAGC ACAAGAGCTCTTCTCTGTTCGACATGGCCCAATTCGAGCGGCTAGAATCTTG CCTGCTCCACAGTTTGGTGCTCAAAAATGTGATAACTTTGCTGAAAAAAGA CCCCTCCTTGGTGTTTGTAAGAGCATTGGATCTTCTGGCACAAGCCCACCGT ACTGTTGTGTGGATCTGTATTCACTTCGTACTGGGGAGATGGTCAAGTCCAT TCAATTTAAGACACCTATTTATGATCTCCATTGCAATAAACGGATCCTTGTC GTAGTCTTGCAGGAGAAAATTGCTGCCTTTGATAGCTGTACTTTCACGAAG AAATTCTTTGTTACAAGCTGCTATCCATGTCCAGGGCCAAACATGAATCCTA TTGCTCTTGGGAGCCGCTGGCTTGCTTATGCAGAAAACAAGTTGATTCGATG TCATCAGTCCCGTGGTGGAGCCTGTGGAGACAACATTCAGTCTTATACTGCC ACAGTCATTAGTGCTGCTAAAACATTGAAAAGTGGCCTGACAATGGTAGGG AAAGTGGTGACTCAGCTGACAGGCACACTGCCTTCAGGTGTGACAGAAGAT GATGTTGCCATCCACAGTAATTCACGGCGGAGTCCTTTGGTCCCAGGCATC ATCACAGTTATTGACACCGAAACCGTTGGAGAGGGCCAGGTGCTTGTGAGT GAGGATTCTGACAGTGATGGCATTGTGGCCCACTTCCCTGCCCATGAGAAG CCAGTGTGCTGCATGGCTTTTAATACAAGTGGAATGCTTCTAGTCACAACA GACACCCTTGGCCATGACTTTCATGTCTTCCAAATTCTGACTCATCCTTGGT CCTCATCACAATGTGCTGTCCACCATCTGTATACTCTTCACAGGGGAGAAAC TGAAGCCAAAGTACAGGACATCTGCTTCAGCCATGACTGTCGCTGGGTTGT GGTCAGTACTCTCCGGGGTACTTCCCACGTTTTCCCCATCAACCCTTATGGT GGCCAGCCTTGTGTTCGTACACATATGTCACCACGAGTAGTGAATCGCATG AGCCGTTTCCAGAAAAGTGCTGGACTGGAAGAGATTGAACAAGAACTGAC GTCTAAGCAAGGAGGTCGCTGTAGCCCTGTTCCAGGTCTATCAAGCAGCCC TTCTGGGTCACCCTTGCATGGGAAACTGAACAGCCAAGACTCCTATAACAA TTTTACCAACAACAACCCTGGCAACCCTCGGCTCTCTCCTCTTCCCAGCTTG ATGGTAGTGATGCCTCTTGCACAAATCAAGCAGCCAATGACATTGGGGACC ATCACCAAACGAACCGGCAAAGTTAAACCTCCTCCACAAATTTCACCCAGC AAATCGATGGGCGGAGAATTTTGTGTGGCTGCTATCTTCGGAACATCCAGG TCATGGTTTGCAAATAATGCAGGTCTGAAAAGAGAAAAAGATCAGTCCAAA CAAGTTGTAGTTGAGTCCCTGTACATTATCAGTTGCTATGGCACCTTAGTGG AACACATGATGGAGCCGCGACCCCTCAGCACTGCACCCAAGATTAGTGACG ACACACCACTGGAAATGATGACATCGCCTCGAGCCAGCTGGACTCTGGTTA GAACCCCTCAATGGAATGAATTGCAGCCACCGTTTAATGCAAACCACCCTC TGCTCCTCGCTGCAGATGCAGTACAGTATTATCAGTTCCTGCTTGCTGGCCT GGTTCCCCCTGGAAGTCCTGGGCCCATTACTCGACATGGGTCTTACGACAGT TTAGCTTCTGACCATAGTGGACAGGAAGATGAAGAATGGCTTTCCCAGGTT GAAATTGTAACACACACTGGACCCCATAGACGTCTGTGGATGGGTCCACAG TTCCAGTTCAAAACCATCCATCCCTCAGGCCAAACCACAGTTATCTCATCCA GTTCATCTGTGTTGCAGTCTCATGGTCCGAGTGACACGCCACAGCCTCTTTT GGATTTTGATACAGATGATCTTGATCTCAACAGTCTCAGGATCCAGCCAGTC CGCTCTGACCCCGTCAGCATGCCAGGGTCATCCCGTCCAGTCTCTGATCGAA GGGGAGTTTCCACAGTGATTGATGCTGCCTCAGGTACCTTTGACAGGAGCG TGACCCTGCTGGAGGTGTGCGGGAGCTGGCCTGAGGGCTTCGGGCTGCGGC ACATGTCCTCCATGGAGCACACGGAGGAGGGCCTCCGGGAGCGACTTGCCG ACGCCATGGCCGAGTCACCTAGCCGGGACGTCGTGGGATCCGGAACAGAA CTTCAGCGAGAGGGAAGCATCGAGACTCTGAGTAACAGCTCAGGCTCCACC AGCGGCAGCATACCAAGAAACTTTGATGGCTACCGATCTCCGCTGCCCACC AATGAGAGCCAGCCCCTCAGCCTCTTCCCGACTGGCTTCCCGTAG ZBTB46- ATGAACAACCGAAAGGAAGATATGGAAATCACGTCCCACTACCGGCACCT SEQ ID > GCTGCGGGAGCTCAACGAGCAGAGGCAGCACGGCGTCCTGTGCGACGTCTG NO: 100 DNAJC5 CGTGGTCGTGGAGGGCAAGGTCTTCAAGGCGCACAAGAACGTCCTGCTGGG CAGCAGCCGCTACTTCAAGACGCTCTACTGCCAGGTGCAGAAGACGTCGGA GCAGGCCACGGTCACGCACCTGGACATCGTCACGGCCCAGGGCTTCAAGGC CATCATCGACTTCATGTACTCAGCGCACCTGGCGCTCACCAGCAGGAACGT CATCGAGGTGATGTCAGCCGCCAGCTTCCTGCAGATGACGGACATCGTGCA AGCCTGCCACGACTTCATCAAGGCGGCGCTGGACATCAGCATCAAGTCGGA CGCCTCAGATGAGCTTGCGGAGTTCGAGATCGGCGCCTCGTCCAGCAGCAG CACGGAAGCTCTCATCTCGGCCGTGATGGCTGGGAGGAGCATCTCCCCGTG GCTGGCACGGCGAACGAGTCCTGCCAATTCTTCCGGAGACTCGGCCATCGC CAGCTGTCACGACGGAGGGAGCAGCTACGGGAAAGAGGATCAGGAGCCCA AGGCCGATGGCCCTGATGATGTTTCTTCACAGCCTCTATGGCCTGGAGACGT GGGCTACGGGCCTCTGCGCATCAAGGAAGAGCAGGTTTCACCGTCTCAGTA CGGAGGGAGCGAGCTGCCTTCTGCCAAGGACGGTGCAGTACAGAACTCTTT CTCAGAGCAGAGTGCTGGTGATGCCTGGCAGCCCACGGGCCGAAGGAAGA ATCGGAAAAACAAAGAGACCGTCCGGCACATCACACAGCAGGTGGAAGAT GACAGCCGGGCCAGCTCCCCGGTGCCGTCCTTCCTGCCGACGTCGGGGTGG CCGTTCAGCAGCCGAGACTCAAATGGCAGACCAGAGACAGCGCTCACTGTC TACCTCTGGGGAGTCATTGTACCACGTCCTTGGGTTGGACAAGAACGCAAC CTCAGATGACATTAAAAAGTCCTATCGGAAGCTTGCCTTGAAATATCACCC CGACAAGAACCCCGACAACCCGGAGGCCGCGGACAAGTTTAAGGAGATCA ACAACGCGCACGCCATCCTCACGGACGCCACAAAAAGGAACATCTACGAC AAGTACGGCTCGCTGGGTCTCTACGTGGCCGAGCAGTTTGGGGAAGAGAAC GTGAACACCTACTTCGTGCTGTCCAGCTGGTGGGCCAAGGCCCTGTTTGTCT TCTGCGGCCTCCTCACGTGCTGCTACTGCTGCTGCTGTCTGTGCTGCTGCTTC AACTGCTGCTGCGGGAAGTGTAAGCCCAAGGCGCCTGAAGGCGAGGAGAC GGAGTTCTACGTGTCCCCCGAGGATCTGGAGGCACAGCTGCAGTCTGACGA GAGGGAGGCCACAGACACGCCGATCGTCATACAGCCGGCATCCGCCACCG AGACCACCCAGCTCACAGCCGACTCCCACCCCAGCTACCACACTGACGGGT TCAACTAA

TABLE C PS6 ->- TCGCTC A ATGGTCTTAAAAT KA chrX: ACGC GGTTGATGAGCCA 6 8341 ATGG 9395 +chr 12:12 BC 2473 AACAGTTCCTCCC L7 333- TTGACA CAGGGATGATGG AGTTCA CCTTTG ACATGCATGGGA >c > - chrl2 ACTCCC TTTCAT GTTGAACTTGTCA 12o :1038 AACAGTT ATGCAT ACATAT AATTAATGTCTAC rf42 7222 Man CCTCCCC GTCCAT CACTGT 12 AGTGATATGTATG 12 5 ual 85 AGGGA 121 C 122 AGAC 3 AAACAAAGG 4

chrl4 CCTGCGCCGCGAC CD :1035 AAGTACGTGGCC C42 2333 CCTCAA GAGTTCCTCGAGT BP 6->- ACACC GGGGTGTTTGAGG B- chr4: CCACTC TCTTGC AACTGTGGAAGA >P 1525 CCTGCGC GAGGA CTTCCC GGGAAGGCAAGA ET 9404 Man CGCGACA ACTCG TCTTCC 12 12 112 8 ual 75 AGTA 125 GCC 126 ACAG 7 8 CL +chr CTGACTCGGGAG EC 16:1 1 GAGGACCTGATC 16 1548 TGTCAG GATAG AAGACTGATGAT A- 79->- ATCCA GTTGGT GTCCTGGATCTGA >B chrl6 CTGACTC GGACA ACATG CAAAAAATCACC CA :1 191 Prim GGGAGGA TCATCA GTGATT 13 ATGTACCAACCTA 13 R4 4154 er3 76 GGAC 129 GTCTTG 130 TT 1 TC 2

chr5: 1758 ACATGGGGACCA 3725 CAGTCAATGGAG CL 8- CTGGG ATGTGTTTCAGGT TB- >+ch CACCTG AGGGT GCCCAGGCCTTCT >C r5:17 ACATGGG AAACA CATTGT GGTTGGTAGCGG DH 5995 Prim GACCACA CATCTC CCTGGT 13 AAGACCAGGACA 13 R2 679 er3 82 GTCAA 133 CA 134 CTT 5 ATGACCCT 6 CR +chr GGTGCCAACTCCA EB 2:208 ACTGA ATTTACCAAACTA 1- 4350 ACGAA GCAGT GCAGTGGACAGT >T 45->- GGTGCCA TGTATA ACTTCT ATACATTCGTTCA ME chr2: ACTCCAA CTGTCC ATTATG GTCAGAGAGCAT M l 9854 Man TTTACCA ACTGCT CTCTCT 13 AATAGAAGTACT 14 3 1 3950 ual 77 AA 137 AG 138 G 9 GC 0

chrl7 :6249 CCCAAGTTGCTTC 6667 AGTTGGTCGAAG ->- CGAAG ACAGAGGTTCAG DD chr3: ACAGA TTGCAG AGTCAGAATGAG X5- 1976 CCCAAGT GGTTCA TTGGTC TATATTGCTAACC >IQ 4091 Prim TGCTTCA GAGTC CTTGAG 14 TCAAGGACCAACT 14 CG 3 er3 79 GTTGGT 141 A 142 GT 3 GCAA 4

chrlO :7961 3 112 ACCAGAAGGAGA TCGGTGACCTCCG DL >+ch AATCAT CTGCTT TGCCCAGCAGCA G5- rl0:7 ACCAGAA CCACTG TGTGTG GCAGTGGATGATT >A 6153 Prim GGAGATC CTGCTG GCTGTT 14 CAACAGCCACAC 14 DK 899 er3 69 GGTGAC 145 CTGGG 146 G 7 AAAGCAG 8 DN TGCCTGC AATCG CGGGG TGCCTGCCGCGCC MB chrlO Man CGCGCCG GAACT TCTCAA 15 GAGGGACCGCCG 15 P- :1017 ual 74 A 149 CCTGCT 150 ATGCCT 1 GGCGGCGGAAAG 2 >τ 6959 TTCCGC CTTC CAGGAGTTCCGAT AC 5- CGC TCTGAAGAGGCAT C2 >+ch TTGAGACCCCG rlO:l 2395 4555 +chr CCTACAGCTTATT EIF 1:364 AGGAA ATCGTCATCCTGC 2C3 9289 TTATCA CGGGGAAGACAC 9->- CCTACAG TACACT GTTTTC CAGTGTATGATAA >Z chrl6 CTTATTA GGTGTC CCCAT TTCCTACCAACAA P2 :2121 Man TCGTCAT TTCCCC AAGGT 15 CCTTATGGGGAAA 15 2879 ual 79 CC 153 GGC 154 TGTTGG 5 AC 6

EIF chrl7 ACGTTCGACACCA 4A :7812 TGGGCCTGCGGG 3- 0592 TCGTTC AGGACCTGCTGCG >T ->- CTCGTA CACCA GGGCATCTACGCT SP chr21 ACGTTCG AGCGT CCGTC TACGAGGAACGA EA :4595 Man ACACCAT AGATG AGCAG 15 GTACCTGCTGACG 16 R 3806 ual 82 GGGC 157 CCCC 158 GTA 9 GTGGTG 0 +chr TTTGGGAGCCTGG 17:37 CATTGA CATTTCTGCCGGA ER 8687 ATCATC GAGCTTTGATGGA BB 01->- CATCA TCTTTC TGATTCAATGAAA 2- chrl7 TTTGGGA AAGCT ACTGTA GTGAAAGATGAA >IK :3794 Man GCCTGGC CTCCGG TTCATC 16 16 TACAGTGAAAGA ZF3 9186 ual 76 ATTT 161 C 162 TTTCAC 3 4 +chr 6:152 GCTCCGCAAATGC ES 2019 AGTCTC TACGAAGTGGGA Rl- 06- TCTGTC GAGTCT ATGATGAAAGGT >A >+ch CAACA CTTTTG GTTGGACAGAGA KA r6:15 GCTCCGC CCTTTC CTCAC GACTCTGAAGATG P12 1669 Man AAATGCT ATCATT ATCTTC 16 TGAGCAAAAGAG 16 846 ual 78 ACGAAG 165 ccc 166 A 7 ACTC 8 +chr 6:152 2656 ATGATCAACTGGG ES 43- CGAAGAGGGTGC Rl- >+ch GGTGC CGGAG CAGTTGGACAGA >A r6:15 ATGATCA CAGTTG TCTCTT GAGACTCTGAAG KA 1669 Prim ACTGGGC GACAG TTGCTC 17 ATGTGAGCAAAA 17 P12 846 er3 70 GAAGAG 169 AGAG 170 ACA 1 GAGACTCCG 2 ACCTGGAGAACG AGCCCAGCGGCT ACACGGTGCGCG +chr AGGCCGGCCCGC 6:152 CGGCATTCTACAG ES 1294 TCCACCAATCGAT Rl- 99- CCTGTG TACTTTGATGTAT >C >+ch CGCCG ACCCA TTAAAGAATCAA 6orf r6:15 ACCTGGA GCATTC TAGAA AAGAGCAAAATT 211 1785 Man GAACGAG TACAGT ATTTTG 17 TCTATGGGTCACA 17 * 588 ual 126 CCCA 173 CCACC 174 C 5 GG 6 +chr 6:152 TACACGGTGCGCG ES 1294 GCTCTT AGGCCGGCCCGC Rl- 99- CCGGC TTGATT CGGCATTCTACAG >C >+ch ATTCTA CTTTAA TCCACCAATCGAT 6orf r6:15 TACACGG CAGTCC ATACAT TACTTTGATGTAT 211 1785 Man TGCGCGA ACCAA CAAAG 17 TTAAAGAATCAA 18 ** 588 ual 82 G 177 TCGA 178 TA 9 AAGAGC 0 FA +chr AGCTCCT ATAGC TCATTT AGCTCCTCCGTTC Ml 6:71 1 Prim CCGTTCG AACAT TTGATG 18 GACAGGCGGGGG 18 35 2340 er3 80 ACAG 181 CTCTCG 182 AATCTG 3 AAGAGGCCGAGC 4 A- 5- CCCGG TCCTC CGGGCGAGAGAT >P >+ch CT GTTGCTATGAGGA KI r6:12 CAGATTCATCAAA B 3038 AATGA 932

chrl7 FB :3745 GGAACATTGAAG XL 3380 TTTACA TACTGAATCTAAA 20- ACGCG TCCATA TGGGTGTACAAA >N >+ch GGAACAT TCTGTT TAACA GACAACAGACGC SF rl7:4 TGAAGTA GTCTTT GGATG GTTGTAAACATGT 4751 Man CTGAATC GTACA CCTTTA 18 TAAAGGCATCCTG 18 780 ual 84 TAA 185 CCC 186 AC 7 TTATATGGA 8

chr4: FB 1533 XW 3245 TCCTCCCCATTCT 7- 5->- AGTTTT ATACAAAAACAA >M chr7: TCCTCCC CCCCCT CTGTCC CAAAAACCTCGA LL 1520 CATTCTA ACTTCG TCATCT AGTAGGGGGAAA 5576 Prim TACAAAA AGGTTT TCCACT 19 ACTGCAGTGGAA 19 0 er3 72 AC 189 TTGTT 190 GC 1 GATGAGGACAG 2 TCCTGCAGCGGGC +chr GGCCCCCTGCAGC 7:560 ATTCTT CTCCTGCCCAGGC GB 3239 GAATC TCCGATTCAAGAA AS- 4->- GGAGC CTGATA TGGCTTTGTTTAA >P chr7: TCCTGCA CTGGG TTGCTC ATTGCCAAACCCA CL 8259 Man GCGGGCG CAGGA TCTGGG 19 GAGAGCAATATC 19 O 5803 ual 92 GC 193 GGCTG 194 TTTGGC 5 AG 6 GR +chr TGGCA TTGGTCTGTGGAG EB 2:116 CACTAC TGCCTGAAGTGAC 1- 8023 AAAGT CAGCTTTTTGTAA >M 4->- TGACCT CTGCTA GGTCAACTTTGTA BO chr2: TTGGTCT TACAA GCAAG GTGTGCCAACTCT AT 9098 Man GTGGAGT AAAGC GCAAA 19 TTGCCTTGCTAGC 20 2 771 ual 80 GCCTGA 197 TGG 198 GAG 9 AG 0 TGGGCAGTGTGCC chr3: AGGGTCCCTTGCG HH 4274 CCTTGC GCCTCCTCAAGGT AT 4071 GGCCTC CTGCCT TTTGAACGAAGA L- CTCAA TGTACC ->- ATGTGATCAGAAC >G chrl7 TGGGCAG GGTTTT AGTTCT TGGTACAAGGCA RB :7332 Man TGTGCCA GAACG GATCA 20 20 G 2 8878 ual 77 GGGT 201 AA 202 C 3 4 +chr 15:99 IGF 4428 AAAACCTTCGCCT 1R- 50- TGAAA CATCCTAGGAGA >D >+ch ACCCTT AAGCG GGAGCAGCTAGA CC rl8:5 AAAACCT CTAGCT CAGTG AGGGTTTTCAAAT 0278 Prim TCGCCTC GCTCCT CTGTGA 20 TAAAGCTTTCACA 20 424 er3 74 ATCCTA 205 CTCC 206 AA 7 GCACTGCGCTT 8

chr20 KIF :1655 TGAGCGATGGCAT 16B 3874 CGGTCAAGGTGG TCCGGC CCGTGAGGGTCCG >P >+ch CCATG AGTGG GCCCATGAATCGC CS r20:l TGAGCGA AATCG TACAG AGCTTCCCTTTGC K2 7240 Man TGGCATC CAGCTT ACCTTC 2 1 TGAAGGTCTGTAC 2 1 885 ual 8 1 GGTC 209 CCCTTT 210 AGC 1 CACT 2 LR +chr GCTGCTG CCCGG CCCCA GCTGCTGGCGCTG P5- 11:68 Man GCGCTGT CCCCCG AGAAA 2 1 TGCGGCTGCCCGG 2 1 >K 0802 ual 9 1 GCGGCT 213 CCGCG 214 CTAGTC 5 CCCCCGCCGCGGG 6 AT 73->- GGATTC AGCAC ATTCTTTCTACTA 6A chr8: TTTCTA TTCAAC ATCCAGATACTTG 4190 c TTGAAGTGCTGAC 7225 TAGTTTCTTGGGG LR +chr P5- 11:68 >S 1331 TCATGG CAACGGCAGGAC LC 70->- TGGATC GGACT GTGTAAGGCAGCT 22 chrl l CAACGGC TCACA GCATC TGTGAGATCCACC A2 :6286 Prim AGGACGT AGCTG CAACT 2 1 ATGAAGAAGGAG 22 4 3578 er3 63 GTAA 217 CC 218 CCTTC 9 TTGGATGCAGTCC 0

LR chrl: AGAAGGACTGCG P8- 5374 AGGGTGGAGCGG >T 6259 CCGGCT GGTTCA ATGAGGCCGGCT ME ->- GTGCTA TAGCA GTGCTACCTGCTA M4 chrl: AGAAGGA CCTGCT GTGCTA TATTCCCAAAGCT 8 5427 Man CTGCGAG ATATTC ATCCA 22 TGGATTAGCACTG 22 5419 ual 84 GGTG 221 CCAA 222 AG 3 CTATGAACC 4 +chr LU 17:48 TGGGA AGAAGCGCAGCA C7 7971 CCACG ACGTGCGGTGGG L3- 92->- AGAGC GTGGT ACCACGAGAGCT >H chrl7 AGAAGCG TGTCCT GTGTG GTCCTCTACAAGC NF :3604 Man CAGCAAC CTACA GGCAT 22 CTGGTGATGCCCA 22 IB 7395 ual 70 GTGC 225 AGCC 226 CAC 7 CACACCAC 8 +chr NF 6:410 CTGGAGCCAATCA YA 4082 TGACC GCGCGGGCAGCG 3- GTTCCG CTCTTC AACCGGGGGAGC >T >+ch TGCCTC ATTGTA GAGGCACGGAAC DR r6:40 CTGGAGC GCTCCC GCTTGA GGTCACTGCGCAG Gl 3470 Man CAATCAG CCGGTT TCCTGC 23 GATCAAGCTACA 23 2 1 ual 82 CGCGGG 229 C 230 GC 1 ATGAAGAG 2

chr5: CATGATGTAGATC 5828 ATCCTGGTGTGTC PD 4320 TGTCCA CAATCAATTTCTG E4 ATCAAT CTCAC ATCAATACAAGA D- >+ch CATGATG TTCTGA AGAGT CAAGCATGACTTT >IT r5:52 TAGATCA TCAATA CCTGA CAGGACTCTGTGA GA 2186 Man TCCTGGT CAAGA AAGTC 23 G 23 1 07 ual 78 G 233 CAAGC 234 A 5 6

PG chrl 7 AP :3784 CCCCCATGTACCA 3- 0850 TGATGT CACCTGTGTGGCC >C ->- CAAAC CCTCCA TTCGCCTGGGAAA AC chrl 7 CCCCCAT ATTTCC ATTGGT TGTTTGACATCAT NB :3733 Prim GTACCAC CAGGC TCTCAT 23 CCTGGATGAGAA 24 1 3788 er3 75 ACCT 237 GA 238 CC 9 CCAATTGGAGG 0 PIK +chr CAGGCACCTGGAT 3C3 18:39 AAAAA AACCTTTTGCTAA 6295 CAGCC CAAAAACAGCCA >R 69->- AAACC TGACAT AACCAAACAGGA PR chrl8 CAGGCAC AAACA CATTGG AGCTTACTTTTCT Dl :3361 Prim CTGGATA GGAAG CTAGGT 24 CTACCTAGCCAAT 24 A 3800 er3 83 ACCTTT 241 C 242 AGAGA 3 GATGTCA 4

PPP chrl 9 GTACTGAGCCTGT 1R1 :5561 TGGAGGAACTGG 2C- 0152 CCCGGAAACAGG >IF ->- GTACTGA CCCTGG AGCGG AGGACGCCCAGG IT chrl l GCCTGTT GCGTCC GGCTG GCCCCGGCCAGTG Ml :1769 Man GGAGGAA TCCTGT GGCAC 24 CCCAGCCCCGCT 24 0 349 ual 74 CTGG 245 TTCCGG 246 TGG 7 8 +chr 19:52 AACAGCTGGGAA PPP 7093 CCTTCACTACCCT 2R1 16- CAGAG GGTGGGAGGCCC A- >+ch TACGTG ATGCA AGAGTACGTGCA >N rl9:5 AACAGCT CACTGC GCCCA CTGCCTGCTGAGC LR 6473 Prim GGGAACC CTGCTG TTGCTC 25 GCCAGAGAGCAA 25 P8* 433 er3 84 TTCACT 249 A 250 TC 1 TGGGCTGCAT 2 +chr PPP 19:52 ATTGCT AACCTTCACTACC 2R1 7093 CTCTGG CTGGTGGGAGGC A- 16- CGCTCA GTCTTG CCAGAGTACGTGC >N >+ch AACCTTC GCAGG CCACC ACTGCCTGCTGAG LR rl9:5 ACTACCC CAGTG AACGA CGCCAGAGAGCA P8* 6473 Man TGGTGGG CACGT TGCAG 25 ATGGGCTGCATCG 25 * 433 ual 89 AG 253 AC 254 C 5 TTGGTGGCAAGAC 6 +chr PPP 10:13 CTTTGACAAGTTT 2R2 3761 GAGTGTTGCTGGA D- 295- CGGCTC CATTTT ACGGTTCGGATAG >P > - CTTTGAC CAAAA GAACA GGTTATTTTGGAG AN chrlO AAGTTTG TAACCC GTTCCA CCGTTGGGGCACT Kl :9134 Man AGTGTTG TATCCG ACAGT 25 GTTGGAACTGTTC 26 4222 ual 84 CTG 257 AACCG 258 GC 9 AAAATG 0

chr20 PR :4732 GCAGATGGAGAA EX 4798 GCTGGAAGCCCTG 1- - GAGCAGCTGCAG >S >+ch CTGCA CATGA TCCCACATCGAAG LC r20:4 GCAGATG GTCCCA GTTGTA GCTGGGAGGAGG 9A 8431 Prim GAGAAGC CATCG TTGGG 26 TTCCCCAATACAA 26 8 545 er3 8 1 TGGAAG 261 AAG 262 GAACC 3 CTCATG 4 +chr RA 17:52 BE 5022 ACTGCGGAAAGA Pl- 0- AGGGC ATTGCATGAAGG >D >+ch CGTCTT CCACCT GTCTTCTGAAGAC NA rl7:l ACTGCGG CAGAA TTCCCA GGCCCTGGATTTC H9 1532 Prim AAAGAAT GACCCT GTTTGT 26 CACAAACTGGGA 26 734 er3 69 TGCAT 265 TC 266 G 7 AAGGTGG 8

chr8: RA 1178 GCAGCGTGGAGA D2 7882 GTATCATCTCACC 1- 5- AGCCC AAAGAAAGGGGA >F >+ch AAACA ACCCCT TGTTTGGGCTGAA ER r8:12 GCAGCGT TCCCCT TCTCTG GGTGAAGAAGAA 1L6 4968 Prim GGAGAGT TTCTTT CCTTAT 27 GAGAAATAAGGC 27 232 er3 85 ATCATC 269 GGTGA 270 TTC 1 AGAGAAGGGGT 2

RA chr3: GCCGAACGACAG Fl- 1270 GACGTTGGGGCG GCCGAAC >N 5312 TCTTCC CATGTA GCCTGGCTCCCTC GACAGGA KI ATTCCT TACATC AGGAATGGAAGA ->- CGTT RA chr3: GAGGG TTCCAT TTGCGAAACAATG SI 2394 Man AGCCA TGTTTC 27 GAAGATGTATAC 27 2540 ual 77 273 GGCC 274 GC 5 ATG 6

RE chrl2 GGAGGTCAAACT RG :1537 GGCAATATTTGGG 0363 AAAGG AGAGCAGGCGTG >G - GGAGGTC AGCTG GCCCC GGCAAGTAGGCA ZM >+ch AAACTGG CCTGAC CGATG GCTCCTTTGGGAC M rl9:5 Man CAATATT TTGCCC ATCTGG 27 CCAGATCATCGGG 28 4728 ual 78 TGGG 277 ACGCC 278 GT 9 GGC 0 0 +chr 8:104 TGTGGAGGTCGA RI 7095 GTGTCATTACGCT MS 24->- CCATTT CAAACAAGCATA 2- chr8: TACCAC GCTGGT GTGGTAAAATGG >D 1054 TGTGGAG TATGCT AACTG ATGAAAACAGAT PY 3661 Prim GTCGAGT TGTTTG CCACA 28 TTGTGGCAGTTAC 28 s 7 er3 78 GTCATT 281 AGCG 282 AATC 3 CAGC 4 +chr 6:710 AGACTCGCAGGA 8001 GCAACACGTGAT RR CTTATC GTGTCTACTTATC EB >+ch AGGTC TGGAT AGGTCAAACCGG 1- r6:75 AGACTCG AAACC GGTGTT CACGATGTCCAGG >D 5595 Prim CAGGAGC GGCAC CTGGTT 28 CACCAGAACCAG 28 SP 1 er3 85 AACA 285 GATG 286 CTG 7 AACACCATCCA 8 TCCTTCGGAGCCG AGCCGTCCGCGCC CGGCGGCGGCGG +chr GAGCCCAGGAGC 11:63 CTGCCCCGCCCTG RT 4492 CCCATT GGGACGAAGAGC N3- 50->- CCGCA GCCAG TGCAGCTCCTCCT >A chr8: TCCTTCG CAGGA ATGCA GTGCGGAATGGG NK 4159 Man GAGCCGA GGAGC AGCCA 29 TTGAATGGCTTGC 29 1* 1587 ual 120 GCCG 289 TGC 290 TTC 1 ATCTGGC 2 +chr CCCCGCCCTGGGG 11:63 CAACC ACGAAGAGCTGC RT 4492 CATTCC GCCTTC AGCTCCTCCTGTG N3- 50->- GCACA CTTAGA CGGAATGGGTTG >A chr8: CCCCGCC GGAGG AGCCA AATGGCTTGCATC NK 4159 Man CTGGGGA AGCTG GATGC 29 TGGCTTCTAAGGA 29 1587 ual 80 CGAA 293 CAGC 294 AAGCC 5 AGGC 6

chr2: SE 9752 MA 7316 ACACTTCAGGCAT 4C- AATAA CTGCAACCTCCGT >B >+ch GCCCTT ACTGA GGCAGTAAGAAA RE r2:28 ACACTTC TCTTAC GGGAC GGGCTTATTTCAA 5613 Prim AGGCATC TGCCAC AAAGG 29 AACCTTTGTCCCT 30 17 er3 68 TGCAAC 297 GGAG 298 TTTTGA 9 CAGT 0

chr2: 9752 GACACTTCAGGCA SE 7316 TCTGCAACCTCCG MA ->- TGGCAGTAAGAA 4C- chr2: CCTCCG AGCCTT AGATGTACAGAA >R 1611 GACACTT TGGCA CACAC AGGTGTTCTTACA BM 3127 Prim CAGGCAT GTAAG CCTTCT 30 TGAAGAAGGGTG 30 SI 5 er3 83 CTGCAA 301 AAAG 302 TCA 3 TGAAGGCT 4 +chr 5:174 AGCGGGACCTGC SF 9056 CATGTA TGGTTT GAGCAGCGCGGG XN 42- GATAC GAGAT CGGCAGCCCGGG 1- >+ch GCTTCC CACGA GGAAGCGTATCTA >c r5:ll AGCGGGA CCCGG TGGAC CATGAAAATGGG AM 0782 Man CCTGCGA GCTGCC AATCC 30 ATTGTCCATCGTG 30 K4 384 ual 85 GCAG 305 GCCC 306 C 7 ATCTCAAACCA 8 +chr CTCCTT TCCCGGGCCGGG 6:158 CGCCC CTTGAA GGACCCGCCCGCC 2444 GCCAT TTTTTT ATGGCCACCAAG 78- GGCCA CATAA GCATTTATTAATA >+ch Man TCCCGGG CCAAG ATTTCT 3 1 CAGCAAAAGAAA 3 1 r8:61 ual 86 CCGGGG 309 GCATTT 310 TTTGCT 1 TTTATGAAAAAAT 2 5311 G TCAAGAAGGAG 39

chr20 ST :4779 GAACTGAACAAA AU 0732 CCTGG GACAACATTGTTC 1- AACGC GATCTT CTGGAACGCCCTC >T >+ch GAACTGA CCTCTT TGTGTT TTTTTAAA AAAGA OP r20:3 ACAAAGA TTTAAA TATCTT TTCTCATAAACAC 1 9690 Man CAACATT AAAGA TGTGTT 3 1 AAAGATAAACAC 3 1 034 ual 83 GTT 313 TTCTC 314 TAT 5 AAAGATC 6 +chr ACTGGTGGGAAA TA 17:61 TCCACA TCAAGTCGTAAAA NC 0869 GCTATT ACAGGTCAAGTG Z- 87->- ACTGGTG TTACCA GATGTC AAAGTGGTAAAA >R chrl7 GGAAATC CTTTCA TTCACT TAGCTGTGGAGTA DM :3424 Man AAGTCGT CTTGAC GGGTCT 3 1 CAGACCCAGTGA 32 1 7276 ual 8 1 AA 317 CTG 318 GTA 9 AGACATC 0

chr9: CCCTCGCTTGTCT TE 1031 TCTCGGGCTTCTC XI 1505 CGGCC GCCCCGGCCGCG 0- 4->- GGGTC TTCACA GCCGGGTCCTCAG >PI chrl l CCCTCGC CTCAG TTCATC ACTTAATTCAGTG CA :8574 Prim TTGTCTT ACTTAA TCATTT 32 CACAAATGAGAT 32 LM 2653 er3 85 CTCG 321 TTCA 322 GTGC 3 GAATGTGAA 4 +chr 3:100 TF 4389 CTGAA TGCAATTCAGTGC G- 02- ACTGA AGTAGGATACTG >G >+ch CATTAT TCTGTA AAACTGACATTAT PR r3:10 TGCAATT TTGGA GGGGT TTGGAAAATCTAC 128 0348 Man CAGTGCA AAATCT GCTTGA 32 TTCCTCATCAAGC 32 442 ual 75 GTAGGAT 325 ACTTCC 326 T 7 ACCCCTACAGA 8 +chr 13:10 CATCGCAGTCCTG 3249 GACACGGGGGTC TP 553- TCCGG GACCCGGGGGCT P2- >+ch GCATG CCTAC CCGGGCATGCAG >B rl3:3 CATCGCA CAGAC GATATT ACTTATTTACCAA RC 2890 Prim GTCCTGG TTATTT CCTCCA 33 GCATTGGAGGAA 33 A2 559 er3 83 ACAC 329 ACCA 330 ATGC 1 TATCGTAGG 2

chrl7 TRI :5709 TGCGGTTGAGAA M3 2971 CCAGA AAGGAGGAAAAT 7- TTTCTT CATTCC GGTCACCTTGGGA >B >+ch GATGT CAGTA TACATCAAGAAAT CA rl7:5 TGCGGTT ATCCCA CTATGT CTGGAATTTCATG S3 8786 Man GAGAAAA AGGTG ATTTCA 33 AAATACATAGTAC 33 580 ual 84 GGAGG 333 ACC 334 TGAAA 5 TGGGAATG 6

chr8: 1166 GTGTTCTTGACGA TR 8077 AGGCT TTAATCAACAGTC PS1 2->- CCGCAT CCACG CAATATCAGATGG chr8: GTGTTCT CATTTC TGAAG AAATGATGCGGA >EI 1176 TGACGAT CATCTG ATGATC GCCTTCGCCATGT F3 7121 Man TAATCAA ATATTG AATGTT 33 AAACATTGATCAT 34 H 9 ual 87 CAG 337 G 338 TA 9 CTTCACGTGG 0 +chr CCTTCCTTATAGG UC 1:165 CGTCAGCGGGGG K2- 7971 GGAAC GGCCG AACAGCTAGCGG >T 69->- CCTTCCT AGCTA AGAAT CAAGAACATTCA MC chrl: Prim TATAGGC GCGGC CTTCTG 34 GAAGATTCTCGGC 34 Ol 1656 er3 63 GTCAGC 341 AAG 342 AATG 3 C 4 9735 8 +chr GTCTATGACATGC UT 17:49 TGGCTGGAAAGTT P18 3546 CGCCC GCTGGT AATTCCTGTGCAT 65->- GTCTATG GAGGA TATTGG CAAGTGAGAGGT >A chrl7 ACATGCT CCTCTC AGGTG CCTCGGGCGGGA CA :3548 Man GGCTGGA ACTTGA TACACT 34 AGTGTACACCTCC 34 CA 7144 ual 86 AA 345 TGC 346 T 7 AATAACCAGC 8 +chr UT 8:117 TACCTCATGGGGG P23 7790 AGACGCAGCTGT 30->- CAGCT GCACCACAAGGTT >R chr8: GTGCA TCTGGC TTCTTCTGTTTTCA AD 1178 TACCTCA CCACA TGGCTA TAGCCAGCCAGA 2 1 7900 Prim TGGGGGA AGGTTT TGAAA 35 35 0 er3 64 GACG 349 TCTTC 350 ACA 1 2 +chr 9:129 CGCGGGCGGGCG ZB 6230 CAAATT ATGTGAGCGCGG TB 18->- CAGTCC CATCTT CGCTCTGGACAGG 34- chr9: TGTCCA CAGCA ACTGAATTTGCTC >S 1278 CGCGGGC GAGCG CCTCCA TTAAAGAAATCAT CA 1828 Man GGGCGAT CCGCG GAGGA 35 GTCCTCTGGAGGT 35 I 6 ual 86 GT 353 CTC 354 CATG 5 GCTGAAGATG 6 # Internal control. * Old design, which was found to not be optimal ** New design WHAT IS CLAIMED IS: 1. A method for identifying a gene fusion in a biological sample obtained from a patient with cancer, comprising: obtaining a plurality of reads from RNA sequencing of the biological sample; mapping a read to the human genome; determining whether the read comprises a distant spliced junction; selecting the read comprising a distant spliced junction; identifying a candidate gene fusion comprising the distant spliced junction; creating a first set of templates for the candidate gene fusion, wherein the first set of templates comprises: (1) a fusion template comprising 50 base pairs (bp) of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (2) a donor template comprising 50 bp of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a discarded region of an donor gene, (3) an acceptor template comprising 50 bp of exonic sequence of a discarded region of a acceptor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (4) a donor genomic template comprising 50 bp upstream genomic sequence of a donor splicing site and 50 bp downstream genomic sequence of a donor splicing site, and (5) an acceptor genomic template comprising 50 bp upstream genomic sequence of an acceptor splicing site and 50 bp downstream genomic sequence of an acceptor splicing site; removing the candidate gene fusion if any of the first template set sequences are identical, but map to different genes in the human genome; creating a second set of templates comprising: (a) a fusion template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (b) a donor template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a discarded region of an donor gene, (c) an acceptor template comprising 150 bp of exonic sequence of a discarded region of a acceptor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (d) a donor genomic template comprising 150 bp upstream genomic sequence of a donor splicing site and 150 bp downstream genomic sequence of a donor splicing site, and (e) an acceptor genomic template comprising 150 bp upstream genomic sequence of an acceptor splicing site and 150 bp downstream genomic sequence of an acceptor splicing site; determining the homology between templates (b) and (c) and between templates (d) and (e); removing the candidate gene fusion if templates (b) and (c) are homologous or if templates (d) and (e) are homologous; and aligning a read obtained from RNA sequencing of the biological sample to the first set of templates; selecting the read that maps to the fusion template of the first set of templates; and identifying a gene fusion, wherein the gene fusion is identified by at least two non- duplicate reads that map to the fusion template of the first set of templates.

2. A method for identifying a gene fusion in a biological sample obtained from a patient with cancer, comprising: obtaining a plurality of reads from RNA sequencing of the biological sample; mapping a read to the human genome; determining whether the read comprises a distant spliced junction; selecting the read comprising a distant spliced junction; identifying a candidate gene fusion comprising the distant spliced junction; creating a first set of templates for the candidate gene fusion, wherein the first set of templates comprises: (1) a fusion template comprising 50 base pairs (bp) of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (2) a donor template comprising 50 bp of exonic sequence of a preserved region of a donor gene and 50 bp of exonic sequence of a discarded region of an donor gene, (3) an acceptor template comprising 50 bp of exonic sequence of a discarded region of a acceptor gene and 50 bp of exonic sequence of a preserved region of an acceptor gene, (4) a donor genomic template comprising 50 bp upstream genomic sequence of a donor splicing site and 50 bp downstream genomic sequence of a donor splicing site, and (5) an acceptor genomic template comprising 50 bp upstream genomic sequence of an acceptor splicing site and 50 bp downstream genomic sequence of an acceptor splicing site; removing the candidate gene fusion if any of the first template set sequences are identical, but map to different genes in the human genome; creating a second set of templates comprising: (a) a fusion template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (b) a donor template comprising 150 bp of exonic sequence of a preserved region of a donor gene and 150 bp of exonic sequence of a discarded region of an donor gene, (c) an acceptor template comprising 150 bp of exonic sequence of a discarded region of a acceptor gene and 150 bp of exonic sequence of a preserved region of an acceptor gene, (d) a donor genomic template comprising 150 bp upstream genomic sequence of a donor splicing site and 150 bp downstream genomic sequence of a donor splicing site, and (e) an acceptor genomic template comprising 150 bp upstream genomic sequence of an acceptor splicing site and 150 bp downstream genomic sequence of an acceptor splicing site; determining the homology between templates (b) and (c) and between templates (d) and (e); removing the candidate gene fusion if templates (b) and (c) are homologous or if templates (d) and (e) are homologous; and aligning a read obtained from RNA sequencing of the biological sample to the first set of templates; selecting the read that maps to the fusion template of the first set of templates; identifying a candidate gene fusion having one non-duplicate read that maps to the fusion template of the first set of templates; determining and comparing the expression levels of the exons and introns of the preserved regions of the donor gene and the acceptor gene to the expression levels of the exons and introns of the discarded regions of the donor gene and the acceptor gene; identifying a gene fusion, wherein the gene fusion has increased expression levels of exons and introns of the preserved regions of the donor gene and the acceptor gene compared to the expression levels of the exons and introns of the discarded regions of the donor gene and the acceptor gene.

3. The method of claim 2 or 3, further comprising preparing a report based on the identification of a gene fusion.

4. A method for predicting the presence of a gene fusion in a biological sample obtained from a patient with cancer, comprising: identifying a gene fusion according to any of claims 1-3 in a first biological sample; obtaining a second biological sample that does not have reads that map to the gene fusion; determining in the second biological sample the expression levels of exons and introns of preserved and discarded regions of a donor gene and an acceptor gene of the gene fusion identified in any of claims 1-3 ; comparing the expression levels of the second biological sample to the expression levels of the first biological sample; and predicting the presence of the gene fusion in the second biological sample that has a similar expression profile compared to the first biological sample. 5. The method of claim 4, further comprising preparing a report based on the prediction of a gene fusion.

6. A method for identifying an alternatively spliced junction in a biological sample obtained from a patient with cancer, comprising: obtaining a plurality of reads from RNA sequencing of the biological sample; mapping the reads to the human genome; determining whether the reads comprise a distant spliced junction; selecting the reads comprising a distant spliced junction; determining whether the distant spliced junction is present in a single gene; and selecting the distant spliced junction that is present in a single gene, wherein the distant spliced junction that is present in a single gene is an alternatively spliced junction.

7. The method of any one of claims 1-6, wherein the read is a single end read.

8. The method of any one of claims 1-6, wherein the read is a paired-end read.

9. The method of any one of claims 1-8, wherein the read is at least 50 bases.

10. The method of any one of claims 1-9, wherein the read is 50 bases.

11. The method of any one of claims 1-10, wherein the cancer is selected from breast cancer, colon cancer, lung cancer, prostate cancer, hepatocellular cancer, gastric cancer, pancreatic cancer, cervical cancer, ovarian cancer, liver cancer, bladder cancer, cancer of the urinary tract, thyroid cancer, renal cancer, carcinoma, melanoma, and brain cancer.

12. A method for predicting a risk of recurrence of breast cancer in a breast cancer patient, comprising: determining the presence of an alternative spliced junction in a breast cancer tumor sample obtained from said patient, wherein the alternative spliced junction is selected from Table 5, and predicting a likelihood of clinical outcome of said patient, wherein the presence of junction -chr3:196118684_-chr3:196129890 in UBXN, junction -chrl2:24366277_- chrl2:24048958 in SOX5, junction -chr9:114148657_-chr9: 114154104 in KIAA0368, junction +chrl8:39629569_+chrl8:39623697 in PIK3C3, or junction +chrl:155695810_chrl:155695173 is correlated with an decreased risk of recurrence, and wherein the presence of junction -chr2:99786013_-chr2:99787892 in MITD1 is correlated with an increased risk of recurrence.

13. The method of claim 12, further comprising preparing a report based on the risk of recurrence.

14. The method of claim 12 or 13, wherein presence of an alternative spliced junction is determined by whole transcriptome sequencing.

15. The method of claim 12 or 13, wherein the presence of an alternative spliced junction is determined by reverse transcription polymerase chain reaction (RT-PCR).

16. The method of any one of claims 1-15, wherein the biological sample is a formalin-fixed paraffin embedded (FFPE) sample or a fresh frozen sample.

17. The method of any one of claims 1-16, wherein the biological sample is a FFPE sample.

18. A cDNA comprising a gene fusion, wherein the cDNA comprises a sequence selected from SEQ ID NO:l to SEQ ID NO: 100.

19. A cDNA comprising an alternative spliced junction selected from - chrl2:24366277_-chrl2:24048958; -chr9: 114148657_-chr9: 114154104; +chrl8:39629569_+chrl8:39623697; +chrl:155695810_chrl:155695173; and - chr2:99786013_-chr2:99787892.

20. A method of predicting a likelihood of poor prognosis in a breast cancer patient, comprising: identifying gene fusion events in a breast tumor sample from the patient; determining the number of gene fusion events in the breast tumor sample; predicting a likelihood of poor prognosis of the patient using the number of gene fusion events, wherein three or more gene fusion events is positively correlated with an increased likelihood of poor prognosis.

21. The method of claim 20, wherein poor prognosis comprises recurrence of breast cancer.

22. The method of claim 20 or 21, wherein the breast cancer patient is estrogen receptor positive.

23. The method of any one of claims 20-22, wherein the gene fusion events are selected from Table B.

24. The method of any one of claims 20-23, wherein at least one of the gene fusion events comprises at least one gene selected from ESRl, ERBB2, GREBl and GRB2.

25. The method of any one of claims 20-22, wherein at least one gene in the gene fusion events is selected from Table 7.

26. The method of claim 25, wherein at least two of the genes in the gene fusion events are selected from Table 7.

27. The method of claim 26, wherein at least three of the genes in the gene fusion events are selected from Table 7.

28. The method of any one of claims 23-27, wherein the gene fusion event comprises at least one gene selected from AP4E1, ATG5, BSG, CAND1, CCT2, CD24, CIBl, CLTC, CPTIA, DCC, FHL2, GALNTl, GNB5, HPGD, IGFIR, MAPK6, MST4, PEX13, PIP4K2C, PRDX1, PTPRF, TMOD2, and TUBB3.

29. The method of any one of claims 23-27, wherein the gene fusion event comprises at least one gene selected from USP8, ATP5B, BRF2, CDC20, CDCA8, COX6B1, G6PD, IDH2, LEOl, MAT1A, MED13, PGK1, PSMB2, PSMC4, SMARCD2, SMG8, SNRPB2, TFCP2L1, UBB, and VPS4B. 30. The method of any one of claims 23-27', wherein the gene fusion event comprises at least one gene selected from CFLl, HMGCR, IPP, MY05A, MY05C, PAK4, PPPIRIB, RAB11FIP1, SEC23B, SLC6A9, TMED2, TMED9, TMOD3, and TRPM7.

31. The method of any one of claims 23-27, wherein the gene fusion event comprises at least one gene selected from ARPP19, BRIP1, EIF3I, GABPB1, GINS2, H2AFZ, KPNA2, MBD2, OCLN, POLI, QRSL1, and RRM2.

32. The method of any one of claims 23-27, wherein the gene fusion event comprises at least one gene selected from ATP6V0B, DCAF7, HSP90B1, LDHA, LOXL4, MDM2, NQOl, P4HA1, PDIA6, SLC2A1, and TK1.

33. The method of any one of claims 23-27, wherein the gene fusion event comprises at least one gene selected from AKR1A1, SHMT2, BCAP31, and CANX.

34. The method of any one of claims 20-33, wherein identifying gene fusion events in a breast tumor sample from the patient is performed by whole transcriptome sequencing.

35. The method of any one of claims 20-33, wherein identifying gene fusion events in a breast tumor sample from the patient is performed by reverse transcription polymerase chain reaction (RT-PCR).

36. The method of any one of claims 20-35, wherein the breast tumor sample is a formalin-fixed paraffin embedded (FFPE) sample or a fresh frozen sample.

37. The method of any one of claims 20-36, wherein the breast tumor sample is a FFPE sample.

38. The method of any one of claims 20-37, further comprising creating a report based on the number of gene fusion events.