United States Office of Chemical Safety and Environmental Protection Agency Pollution Prevention

Final Scope of the Risk Evaluation for 1,1,2-Trichloroethane

Supplemental File:

Data Extraction and Data Evaluation Tables for Physical and Chemical Property Studies CASRN: 79-00-5

August 2020 Table of Contents

Data Extraction Tables ...... 7 Table 1. Physical State Study Summary for 1,1,2-trichloroethane ...... 7 Table 2. Physical Properties Study Summary for 1,1,2-trichloroethane ...... 7 Table 3. Melting Point Study Summary for 1,1,2-trichloroethane ...... 7 Table 4. Boiling Point Study Summary for 1,1,2-trichloroethane ...... 8 Table 5. Density Study Summary for 1,1,2-trichloroethane ...... 9 Table 6. Vapor Pressure Study Summary for 1,1,2-trichloroethane ...... 10 Table 7. Vapor Density Study Summary for 1,1,2-trichloroethane ...... 10 Table 8. Water Solubility Study Summary for 1,1,2-trichloroethane ...... 11 Table 9. Octanol Water Coefficient (logKow) Study Summary for 1,1,2-trichloroethane ...... 12 Table 10. Henry's Law Constant Study Summary for 1,1,2-trichloroethane ...... 12 Table 11. Flash Point Study Summary for 1,1,2-trichloroethane ...... 12 Table 12. Auto Flammability Study Summary for 1,1,2-trichloroethane ...... 13 Table 13. Viscosity Study Summary for 1,1,2-trichloroethane ...... 13 Table 14. Refractive Index Study Summary for 1,1,2-trichloroethane ...... 13 Table 15. Dielectric Constant Study Summary for 1,1,2-trichloroethane ...... 14 EPI SuiteTM Model Outputs...... 15 Data Evaluation Tables ...... 19 O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 ...... 19 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 21 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 22 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 24 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 ...... 25 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 26 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 27

2 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 28 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 30 O'Neil, MJ. (2013). The Merck index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 ...... 32 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 33 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 35 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 36 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 38 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 40 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 42 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 44 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 ...... 46 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 47 Sathyanarayana, B; Jyostna, TS; Satyanarayana, N. (2006). Acoustic studies of binary mixtures of N- methylacetamide with some chloroethanes and chloroethenes at 308.15 K. Indian J Pure Appl Phys 44: 587-591. HERO ID: 4698397 ...... 48 Sathyanarayana, B; Ranjithkumar, B; Jyostna, TS; Satyanarayana, N. (2007). Densities and viscosities of binary liquid mixtures of N-methylacetamide with some chloroethanes and chloroethenes at T=308.15 K. The Journal of Chemical Thermodynamics 39: 16-21. http://dx.doi.org/10.1016/j.jct.2006.06.009. HERO ID: 4698408 ...... 50 O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 ...... 52 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 53 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 55

3 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 ...... 57 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 58 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 59 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 60 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 62 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 64 Yalkowsky, SH; Mishra, DS. (1991). Vapor pressure estimation for organic compounds. Sci Total Environ 109-110: 243-250. http://dx.doi.org/10.1016/0048-9697(91)90181-D. HERO ID: 598165 ..... 65 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 67 NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 ...... 69 NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 ...... 71 NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 ...... 73 O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 ...... 75 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 76 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 77 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 79 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 81 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 ...... 82

4 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 ...... 83 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 ...... 84 Mueller, M; Klein, W. (1992). Comparative evaluation of methods predicting water solubility for organic compounds. Chemosphere 25: 769-782. http://dx.doi.org/10.1016/0045- 6535(92)90067-2. HERO ID: 654554 ...... 85 Nirmalakhandan, NN; Speece, RE. (1988). Prediction of aqueous solubility of organic chemicals based on molecular structure. Environ Sci Technol 22: 328-338. http://dx.doi.org/10.1021/es00168a014. HERO ID: 654558 ...... 87 Wright, DA; Sandler, SI; Devoll, D. (1992). Infinite dilution activity coefficients and solubilities of halogenated hydrocarbons in water at ambient temperatures. Environ Sci Technol 26: 1828- 1831. http://dx.doi.org/https://pubs.acs.org/doi/pdf/10.1021/es00033a018. HERO ID: 658886 ...... 88 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 89 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 91 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 93 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 95 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Octanol water partition coefficients (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932746 ...... 97 Mueller, M; Klein, W. (1992). Comparative evaluation of methods predicting water solubility for organic compounds. Chemosphere 25: 769-782. http://dx.doi.org/10.1016/0045- 6535(92)90067-2. HERO ID: 654554 ...... 98 U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. HERO ID: 5926138 ...... 100 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 102 Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 ...... 104 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 105 Dreher, EL; Beutel, KK; Myers, JD; Lübbe, T; Krieger, S; Pottenger, LH. (2014). Chloroethanes and chloroethylenes. In B Elvers (Ed.), Ullmann's Encyclopedia of Industrial Chemistry (6th ed., pp. 1-81).

5 Hoboken, NJ: Wiley‐VCH Verlag GmbH & Co. http://dx.doi.org/10.1002/14356007.o06_o01.pub2. HERO ID: 4293766 ...... 107 Rumble, JR. (2018). Flammability of chemical substances. In CRC Handbook of Chemistry and Physics (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 6655446 ...... 109 Sathyanarayana, B; Ranjithkumar, B; Jyostna, TS; Satyanarayana, N. (2007). Densities and viscosities of binary liquid mixtures of N-methylacetamide with some chloroethanes and chloroethenes at T=308.15 K. The Journal of Chemical Thermodynamics 39: 16-21. http://dx.doi.org/10.1016/j.jct.2006.06.009. HERO ID: 4698408 ...... 111 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 113 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 115 O'Neil, MJ. (2013). The Merck index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 ...... 116 NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 ...... 118 RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. http://www.chemspider.com/Chemical- Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c. HERO ID: 5926271 ...... 120 Rumble, JR. (2018). CRC handbook of chemistry and physics. 1,1,2-Trichloroethane. Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 ...... 122 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 123 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 125 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 127 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 129 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 131 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5 [Website]. HERO ID: 5926430 ...... 133 U.S. EPA (U.S. Environmental Protection Agency). (2012). Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11 [Computer Program]. Washington, DC. Retrieved from https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface. HERO ID: 2347246 ...... 135 References ...... 136

6 Data Extraction Tables In each table, the value preliminarily selected for use in the risk evaluation is in bold.

Table 1. Physical State Study Summary for 1,1,2-trichloroethane

Data Quality Study Type Result Comments Affiliated Reference Evaluation Results

Experimental liquid (NLM, 2018) High Experimental liquid (RSC, 2019) High Experimental liquid (RSC, 2019) High Experimental liquid (Rumble, 2018d) High Experimental liquid (O'Neil, 2013) High

Table 2. Physical Properties Study Summary for 1,1,2-trichloroethane

Data Quality Study Type Result Comments Affiliated Reference Evaluation Results

Experimental clear, colorless liquid (NLM, 2018) High Experimental pleasant odor (NLM, 2018) High colorless w/sweet, Experimental (RSC, 2019) High chloroform-like odor colorless w/mild Experimental (RSC, 2019) High chloroform odor

Table 3. Melting Point Study Summary for 1,1,2-trichloroethane

Substance Data Quality Study Type Result Comments Affiliated Reference Purity Evaluation Results

Experimental NR -35°C (NLM, 2018) High Experimental NR -36.6°C (U.S. EPA, 2019) High

7 Substance Data Quality Study Type Result Comments Affiliated Reference Purity Evaluation Results Experimental NR -36.7°C (U.S. EPA, 2019) High Experimental NR -37°C (U.S. EPA, 2019) Medium Experimental NR -35°C (U.S. EPA, 2019) Medium Experimental NR -36.6°C (U.S. EPA, 2019) Medium Experimental NR -35°C (U.S. EPA, 2019) Medium Experimental NR -37°C (U.S. EPA, 2019) Medium Experimental NR -37°C (U.S. EPA, 2019) Medium Experimental NR -37°C (RSC, 2019) Medium Experimental NR -35°C (O'Neil, 2013) High Experimental NR -37.4 to -35.5°C (Elsevier, 2019) High Experimental NR -36.5°C (Rumble, 2018d) High

Table 4. Boiling Point Study Summary for 1,1,2-trichloroethane

Substance Data Quality Study Type Result Comments Affiliated Reference Purity Evaluation Results

Experimental NR 113 - 114°C At 760 mm Hg (NLM, 2018) High Experimental NR 114°C (U.S. EPA, 2019) High Experimental NR 114°C (U.S. EPA, 2019) Medium Experimental NR 114°C (U.S. EPA, 2019) High Experimental NR 114°C (U.S. EPA, 2019) Medium Experimental NR 110 - 115°C (RSC, 2019) Medium Experimental NR 112°C (RSC, 2019) Medium Experimental NR 113°C (Rumble, 2018d) High 760 torr; 21 values were reported in Reaxys; 9 values were reported in the range of 113 to 114.1°C at Experimental NR 113 - 114.1°C 760 torr; 12 values were outside (Elsevier, 2019) High this range or measured at unreported or non- standard pressures.

8 Substance Data Quality Study Type Result Comments Affiliated Reference Purity Evaluation Results Experimental NR 113 - 114°C (O'Neil, 2013) High

Table 5. Density Study Summary for 1,1,2-trichloroethane

Study Reference Dynamic Affiliated Data Quality Study Type Temperature Result Comments Details Substance Viscosity Reference Evaluation Results

1.4416 Experimental 20°C (NLM, 2018) High g/cm3 1.4397 Experimental 20°C (Rumble, 2018d) High g/cm3 1.435 Experimental (RSC, 2019) Medium g/cm3 1.4416 Experimental -20°C 20°C relative to water at 4°C (O'Neil, 2013) High g/cm3 33 values were reported in Reaxys; 16 values were reported in the range of 1.4308 - 1.4308 to 1.4744 at 20-25°C; Experimental 20-25°C 1.4744 (Elsevier, 2019) High 17 values were outside this g/cm3 range or measured at non- standard or unreported temperatures. Value at 298.15 K; 1.43216 Pycnometer was calibrated (Sathyanarayana Experimental 298.15 K High g/cm3 to the density of water at et al., 2006) 298.15K as 0.9970 g/cm3 1.4322 (Sathyanarayana Experimental 25.15°C 298.15 K High kg/m3 et al., 2007)

9 Table 6. Vapor Pressure Study Summary for 1,1,2-trichloroethane Data Quality Substance Study Type Temperature Result Comments Affiliated Reference Evaluation Purity Results

Experimental NR NR 23.0 mm Hg (U.S. EPA, 2019) High Experimental NR 25°C 23 mm Hg (NLM, 2018) High Experimental NR NR 19 mm Hg (RSC, 2019) High 3 data points were reported in Reaxys; 1 value was reported at 23.252 torr at standard 23.252 mm Experimental NR 25°C temperature; 2 data points (Elsevier, 2019) High Hg were outside the range, measured at non-standard or unreported temperatures. Secondary source, units not provided; calculated values testing validity of estimation equations. Primary source: (Yalkowsky and Mishra, Experimental NR NR -1.39 atm Medium Mackay, D, et al., 1982. Environ 1991) Sci Technol 16: 645-49, vapor pressure = 0.399E-1 atm at 25°C

Table 7. Vapor Density Study Summary for 1,1,2-trichloroethane Study Type Study Details Result Comments Affiliated Reference Data Quality Evaluation Results

Experimental 4.21 g/L 760 mm Hg (NLM, 2018) High Experimental 4.63 Relative to air (NLM, 2020) High Relative vapor density Experimental 4.6 (NLM, 2020) High (air = 1) Experimental 4.63 (NLM, 2020) High

10 Table 8. Water Solubility Study Summary for 1,1,2-trichloroethane Data Quality Substance Analytical Affiliated Study Type Temperature pH Result Comments Evaluation Purity Method Reference Results

4590 Experimental NR 25°C NR NR (NLM, 2018) High mg/L 6200 Experimental NR 0°C NR NR (Rumble, 2018a) High mg/L 4580 Experimental NR 25°C NR NR (Rumble, 2018a) High mg/L 5350 Experimental NR 50°C NR NR (Rumble, 2018a) High mg/L Experimental NR NR NR NR Insoluble (O'Neil, 2013) Medium 5 data points were reported in Reaxys; 1 value was reported at 1 g 3697 Experimental NR 25°C NR NR in 270 g H2O at standard (Elsevier, 2019) High mg/L temperature; 4 data points were at non- standard temperatures. 4590 Experimental NR NR NR NR (U.S. EPA, 2019) High mg/L 4000 Experimental NR NR NR NR (RSC, 2019) High mg/L (Nirmalakhandan Not specified NR NR NR NR logS = -0.358 and Speece, High 1988) 4416 (Mueller and Calculation NR NR NR NR Reported as 3.31E-2 mol/L High mg/L Klein, 1992) Result reported as 0.0658-0.0664 4871 – mol%. MW of 1,1,2-trichloroethane (Wright et al., Calculation NR 20°C NR NR 4916 is 133.41 g/mol; MW of water is High 1992) mg/L 18.02 g/mol; assume density of water is 1 g/mL

11 Table 9. Octanol Water Coefficient (logKow) Study Summary for 1,1,2-trichloroethane

Other Study Data Quality Substance Details (Amounts Affiliated Study Type Temperature pH Result Comments Evaluation Purity of substance liquid Reference Results phases)

(U.S. EPA, Experimental NR NR NR NR 1.89 High 2019) Experimental NR NR NR NR 1.89 (NLM, 2018) High Experimental NR NR NR NR 1.43 (NLM, 2018) High 3 values were reported in Reaxys; 1 value was reported at 2.05 at (Elsevier, Experimental NR 25°C NR NR 2.05 High 25°C; 2 values were reported at 2019) unreported temperature. (Rumble, Experimental NR 25°C NR NR 2.38 High 2018c) calculated Pow-values - (Mueller and Calculation NR NR NR NR 2.05 High MedChem- Software 1989 Klein, 1992)

Table 10. Henry's Law Constant Study Summary for 1,1,2-trichloroethane

Study Type Substance Purity Temperature Result Comments Affiliated Reference Data Quality Evaluation Results

8.24E-4 atm- Experimental NR 25°C (NLM, 2018) High m3/mol 8.24E-4 atm- Experimental NR 25°C (U.S. EPA, 2019) High m3/mol 9.08E-4 atm- Experimental NR 25°C (Rumble, 2018a) High m3/mol

Table 11. Flash Point Study Summary for 1,1,2-trichloroethane

Study Type Substance Purity Temperature Result Comments Affiliated Reference Data Quality Evaluation Results

12

Experimental NR 114°C (RSC, 2019) Medium

Table 12. Auto Flammability Study Summary for 1,1,2-trichloroethane

Substance Purity Data Quality Study Type Apparatus Temperature Pressure Result Comments Affiliated Reference Quantity Evaluation Results

Experimental NR 460°C NR (Dreher et al., 2014) High

Not specified NR 460°C NR (Rumble, 2018b) High

Table 13. Viscosity Study Summary for 1,1,2-trichloroethane

Affiliated Data Quality Study Type Apparatus Temperature Result Comments Reference Evaluation Results

Experimental 25°C 1.69 cP (NLM, 2018) High 14 values were reported in Reaxys; 6 values were reported in the range of Experimental 20-25°C 1.49846 cP 1.076 to 1.49846 at 20-25°C; 8 values (Elsevier, 2019) High were outside this range or measured at non-standard temperatures. (Sathyanarayana et Experimental 298.15 K 1105 kg/m.s Value is an average of 3 measurements High al., 2007)

Table 14. Refractive Index Study Summary for 1,1,2-trichloroethane

Data Quality Affiliated Study Type Apparatus Result Comments Evaluation Reference Results

13

Experimental 1.4711 (O'Neil, 2013) High Experimental 1.4711 (NLM, 2018) High Experimental 1.472 (RSC, 2019) Medium (Rumble, Experimental 1.4714 High 2018d) 20-25°C; 16 values were reported in Reaxys; 13 values were reported 1.447 - (Elsevier, Experimental in the range of 1.447 to 1.4773 at 20-25°C; 3 values were measured at High 1.4773 2019) unreported or non-standard temperatures.

Table 15. Dielectric Constant Study Summary for 1,1,2-trichloroethane

Study Type Apparatus Result Comments Affiliated Reference Data Quality Evaluation Results

Experimental 7.29 20°C (Elsevier, 2019) High Experimental 2.47 - 3.6 -132.8 to -36.6°C (Elsevier, 2019) High Experimental 8.45 - 8.65 -35.7 to -20.2°C (Elsevier, 2019) High Experimental 7.12 20°C (Elsevier, 2019) High Experimental 7.131 25°C (Elsevier, 2019) High Experimental 7.28 20°C (Elsevier, 2019) High

14 EPI SuiteTM Model Outputs (U.S. EPA, 2012)

CAS Number: 000079-00-5 SMILES : CLCC(CL)CL CHEM : 1,1,2-TRICHLOROETHANE MOL FOR: C2 H3 CL3 MOL WT : 133.41 ------EPI SUMMARY (v4.11) ------Physical Property Inputs: Log Kow (octanol-water): 1.89 Boiling Point (deg C) : 114.00 Melting Point (deg C) : -36.50 Vapor Pressure (mm Hg) : 23 Water Solubility (mg/L): 4590 Henry LC (atm-m3/mole) : 0.000824

Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v1.69 estimate) = 2.01 Log Kow (Exper. database match) = 1.89 Exper. Ref: HANSCH,C ET AL. (1995)

Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPVP v1.43): Boiling Pt (deg C): 127.75 (Adapted Stein & Brown method) Melting Pt (deg C): -62.59 (Mean or Weighted MP) VP(mm Hg,25 deg C): 20.4 (Mean VP of Antoine & Grain methods) VP (Pa, 25 deg C) : 2.72E+003 (Mean VP of Antoine & Grain methods) MP (exp database): -36.6 deg C BP (exp database): 113.8 deg C VP (exp database): 2.30E+01 mm Hg (3.07E+003 Pa) at 25 deg C

Water Solubility Estimate from Log Kow (WSKOW v1.42): Water Solubility at 25 deg C (mg/L): 3845 log Kow used: 1.89 (user entered) melt pt used: -36.50 deg C Water Sol (Exper. database match) = 4590 mg/L (25 deg C) Exper. Ref: HORVATH,AL ET AL. (1999) Water Sol (Exper. database match) = 1100 mg/L (25 deg C) Exper. Ref: TALIAN,SF ET AL. (1986)

Water Sol Estimate from Fragments: Wat Sol (v1.01 est) = 2800.6 mg/L

ECOSAR Class Program (ECOSAR v1.11): Class(es) found: Neutral Organics

Henrys Law Constant (25 deg C) [HENRYWIN v3.20]: Bond Method : 4.27E-003 atm-m3/mole (4.33E+002 Pa-m3/mole) Group Method: 1.02E-004 atm-m3/mole (1.03E+001 Pa-m3/mole) Exper Database: 8.24E-04 atm-m3/mole (8.35E+001 Pa-m3/mole)

15 For Henry LC Comparison Purposes: User-Entered Henry LC: 8.240E-004 atm-m3/mole (8.349E+001 Pa-m3/mole) Henrys LC [via VP/WSol estimate using User-Entered or Estimated values]: HLC: 8.796E-004 atm-m3/mole (8.913E+001 Pa-m3/mole) VP: 23 mm Hg (source: User-Entered) WS: 4.59E+003 mg/L (source: User-Entered)

Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]: Log Kow used: 1.89 (user entered) Log Kaw used: -1.473 (user entered) Log Koa (KOAWIN v1.10 estimate): 3.363 Log Koa (experimental database): 3.400

Probability of Rapid Biodegradation (BIOWIN v4.10): Biowin1 (Linear Model) : 0.3499 Biowin2 (Non-Linear Model) : 0.0116 Expert Survey Biodegradation Results: Biowin3 (Ultimate Survey Model): 2.3848 (weeks-months) Biowin4 (Primary Survey Model) : 3.3534 (days-weeks ) MITI Biodegradation Probability: Biowin5 (MITI Linear Model) : 0.3569 Biowin6 (MITI Non-Linear Model): 0.0675 Anaerobic Biodegradation Probability: Biowin7 (Anaerobic Linear Model): 0.6522 Ready Biodegradability Prediction: NO

Hydrocarbon Biodegradation (BioHCwin v1.01): Structure incompatible with current estimation method!

Sorption to aerosols (25 Dec C)[AEROWIN v1.00]: Vapor pressure (liquid/subcooled): 3.07E+003 Pa (23 mm Hg) Log Koa (Exp database): 3.400 Kp (particle/gas partition coef. (m3/ug)): Mackay model : 9.78E-010 Octanol/air (Koa) model: 6.17E-010 Fraction sorbed to airborne particulates (phi): Junge-Pankow model : 3.53E-008 Mackay model : 7.83E-008 Octanol/air (Koa) model: 4.93E-008

Atmospheric Oxidation (25 deg C) [AopWin v1.92]: Hydroxyl Radicals Reaction: OVERALL OH Rate Constant = 0.2286 E-12 cm3/molecule-sec Half-Life = 46.785 Days (12-hr day; 1.5E6 OH/cm3) Ozone Reaction: No Ozone Reaction Estimation Fraction sorbed to airborne particulates (phi): 5.68E-008 (Junge-Pankow, Mackay avg) 4.93E-008 (Koa method) Note: the sorbed fraction may be resistant to atmospheric oxidation

Soil Adsorption Coefficient (KOCWIN v2.00): Koc : 60.7 L/kg (MCI method)

16 Log Koc: 1.783 (MCI method) Koc : 43.64 L/kg (Kow method) Log Koc: 1.640 (Kow method) Experimental Log Koc: 1.89 (database)

Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v2.00]: Total Kb for pH > 8 at 25 deg C : 1.876E-002 L/mol-sec Kb Half-Life at pH 8: 1.171 years Kb Half-Life at pH 7: 11.705 years (Total Kb applies only to esters, carbmates, alkyl halides)

Bioaccumulation Estimates (BCFBAF v3.01): Log BCF from regression-based method = 0.914 (BCF = 8.204 L/kg wet-wt) Log Biotransformation Half-life (HL) = -0.3830 days (HL = 0.414 days) Log BCF Arnot-Gobas method (upper trophic) = 0.819 (BCF = 6.585) Log BAF Arnot-Gobas method (upper trophic) = 0.819 (BAF = 6.585) log Kow used: 1.89 (user entered)

Volatilization from Water: Henry LC: 0.000824 atm-m3/mole (entered by user) Half-Life from Model River: 1.999 hours Half-Life from Model Lake : 118.7 hours (4.944 days)

Removal in Wastewater Treatment: Total removal: 27.43 percent Total biodegradation: 0.08 percent Total sludge adsorption: 1.64 percent Total to Air: 25.72 percent (using 10000 hr Bio P,A,S)

Removal in Wastewater Treatment: Total removal: 39.79 percent Total biodegradation: 16.68 percent Total sludge adsorption: 1.43 percent Total to Air: 21.68 percent (using Biowin/EPA draft method)

Level III Fugacity Model: (MCI Method) Mass Amount Half-Life Emissions (percent) (hr) (kg/hr) Air 23.9 1.31e+003 1000 Water 31.7 900 1000 Soil 44.2 1.8e+003 1000 Sediment 0.152 8.1e+003 0 Persistence Time: 308 hr

Level III Fugacity Model: (MCI Method with Water percents) Mass Amount Half-Life Emissions (percent) (hr) (kg/hr) Air 23.9 1.31e+003 1000 Water 31.7 900 1000 water (31.7) biota (0.000123)

17 suspended sediment (0.00289) Soil 44.2 1.8e+003 1000 Sediment 0.152 8.1e+003 0 Persistence Time: 308 hr

Level III Fugacity Model: (EQC Default) Mass Amount Half-Life Emissions (percent) (hr) (kg/hr) Air 28.8 1.31e+003 1000 Water 37.5 900 1000 water (37.5) biota (0.000145) suspended sediment (0.00179) Soil 33.7 1.8e+003 1000 Sediment 0.128 8.1e+003 0 Persistence Time: 262 hr

18 Data Evaluation Tables Study O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Reference: Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 recognized data collection where data are peer- reviewed by experts in the field. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

19 The reviewer agreed with the overall rating for the Physical State reported by this reference.

20 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 publicly available and peer- reviewed database. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical State reported by this reference. Cited reference: IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972 to Present. P. V52: 337

21

Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 4 3 4 High Medium Low Overall Score = 1.33 Overall 1 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical State reported by this reference.

22 Cited reference: Oxford University Chemical Safety Data

23 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 publicly available database that references a peer- reviewed source. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical State reported by this reference. Cited reference: NIOSH

24 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Reference: Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 recognized data collection where data are peer- reviewed by experts in the field. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical State reported by this reference.

25 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00- Reference: 5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 publicly available and peer-reviewed database. Models Not rated Rating of this NR 1 NR factor is not applicable to this kind of information. Sum of scores: 2 2 2 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical Properties reported by this reference. Cited reference: O'Neil, M.J. (Ed.) 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc. 2006. p. 1656.

26 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00- Reference: 5 [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 publicly available and peer-reviewed database. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 2 2 2 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical Properties reported by this reference. Cited reference: IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972 to Present. P. V52: 337

27

Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed original sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 3 2 3 High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors:

28 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical Properties reported by this reference. Cited reference: Oxford University Chemical Safety Data

29 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Not rated Rating of this NR NR NR Reliability Unbiased (Method factor is not Objectivity) applicable to this kind of information. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases High Data is from a 1 1 1 publicly available database that references a peer- reviewed source. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 2 2 2 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Physical Properties reported by this reference.

30 Cited reference: NIOSH

31 Study O'Neil, MJ. (2013). The Merck index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Reference: Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

32 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 9 5 9 High Medium Low Overall Score = 1.8 Overall 1.8 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

33 Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: SynQuest

34 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that references a peer- reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

35 Cited reference: NIOSH Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 9 5 9

36 High Medium Low Overall Score = 1.8 Overall 1.8 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: Oxford University Chemical Safety Data

37 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to the original, peer- reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

38 The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: PhysProp

39 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to a recognized data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

40 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: O'Neil, M.J. (Ed.) 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc. 2006. p. 1656.

41 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 9 5 9

42 High Medium Low Overall Score = 1.8 Overall 1.8 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: Biosynth

43 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness High Measured data 1 1 1 are consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 9 5 9

44 High Medium Low Overall Score = 1.8 Overall 1.8 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference. Cited reference: SynQuest

45 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Reference: Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 4 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

46 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 4 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Boiling Point reported by this reference.

47 Cited reference: Data range determined from multiple primary sources in REAXYS. Study Sathyanarayana, B; Jyostna, TS; Satyanarayana, N. (2006). Acoustic studies of binary Reference: mixtures of N-methylacetamide with some chloroethanes and chloroethenes at 308.15 K. Indian J Pure Appl Phys 44: 587-591. HERO ID: 4698397 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / High The 1 1 1 Reliability Unbiased (Method methodology for Objectivity) producing the information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / High Data are 1 1 1 Analytical Method obtained by accepted standard analytical methods, including, but not limited to OECD guidelines for physical- chemical properties or other developed standard. Other Databases Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information.

48 Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference.

49 Study Sathyanarayana, B; Ranjithkumar, B; Jyostna, TS; Satyanarayana, N. (2007). Densities Reference: and viscosities of binary liquid mixtures of N-methylacetamide with some chloroethanes and chloroethenes at T=308.15 K. The Journal of Chemical Thermodynamics 39: 16-21. http://dx.doi.org/10.1016/j.jct.2006.06.009. HERO ID: 4698408 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / High The 1 1 1 Reliability Unbiased (Method methodology for Objectivity) producing the information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / High Data are 1 1 1 Analytical Method obtained by accepted standard analytical methods, including, but not limited to OECD guidelines for physical- chemical properties or other developed standard. Other Databases Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information.

50 Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference.

51 Study O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Reference: Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 recognized, peer- reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference.

52 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to a peer-reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

53 The reviewer agreed with the overall rating for the Density reported by this reference. Cited reference: O'Neil, M.J. (Ed.) 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc. 2006. p. 1656.

54 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6-4138- 93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 8 4 8

55 High Medium Low Overall Score = 2 Overall 2 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference. Cited reference: SynQuest

56 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. 1,1,2-Trichloroethane. Reference: Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 recognized, peer- reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference.

57 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Density reported by this reference. Cited reference: Data range determined from multiple primary sources in REAXYS.

58 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference. Cited reference: PhysProp. Engineering Sciences Data Unit 1976.

59

Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

60 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference. Cited reference: Engineering Sciences Data Unit. 1976. Vapor pressures and critical points of liquids. VII. Halogenated ethanes and ethylenes. Eng. Sci. data Item. 76004. p. 43.

61 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that references a peer- reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

62 The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference. Cited reference: NIOSH

63 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Pressure reported by this reference.

64 Cited reference: Tse, G.; Sandler, S. I.; Journal of Chemical and Engineering Data; vol. 39; 2; (1994); p. 354-357 Study Yalkowsky, SH; Mishra, DS. (1991). Vapor pressure estimation for organic compounds. Sci Reference: Total Environ 109-110: 243-250. http://dx.doi.org/10.1016/0048-9697(91)90181-D. HERO ID: 598165 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness Low Data are measured or 3 1 3 estimated for the subject chemical substance; however, temperature and VP units are not specified. Appropriateness Low Secondary Source; 3 1 3 Measured data are consistent with the subject chemical's physical/chemical properties; however, temperature and VP units are not specified. Test Reliability / Medium Secondary Source; 2 1 2 Reliability Unbiased (Method There is no Objectivity) indication that the methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 11 5 11

65 High Medium Low Overall Score = Sum 2.2 Overall Score 2.2 of Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall Medium Quality Level: The≥1 and reviewer <1.7 agreed≥1.7 with and the <2.3 overall rating for≥2.3 the and Vapor ≤3 Pressure reported by this reference. Cited reference: Mackay, D, et al., 1982. Environ Sci Technol 16: 645-49

66 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / High The methodology for 1 1 1 Reliability Unbiased (Method producing the Objectivity) information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognizd database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 5 6

High Medium Low Overall Score = 1.2 Overall 1.2 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting

67 Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Density reported by this reference. Cited reference: Flick, E.W. (Ed.). Industrial Solvents Handbook 4th ed. Noyes Data Corporation, Park Ridge, NJ. 1991. p. 143.

68 Study NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Reference: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured or 1 1 1 estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / High The methodology for 1 1 1 Reliability Unbiased (Method producing the Objectivity) information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases Medium The data are from a 2 1 2 source that is known but is missing elements required for High designation such as peer-review, public availability, or the inclusion of references to original sources. Models Not rated Rating of this factor is NR NR NR not applicable to this kind of information. Sum of scores: 7 5 7

High Medium Low Overall Score = Sum 1.4 Overall 1.4

69 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Density reported by this reference. Cited reference: Occupational Safety and Health Administration (OSHA)

70 Study NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Reference: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / High The methodology for 1 1 1 Reliability Unbiased (Method producing the Objectivity) information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases Medium The data are from a 2 1 2 source that is known but is missing elements required for High designation such as peer-review, public availability, or the inclusion of references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information.

71 Sum of scores: 7 5 7

High Medium Low Overall Score = 1.4 Overall 1.4 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Density reported by this reference. Cited reference: ILO International Chemical Safety Cards (ICSC)

72 Study NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem Database: Reference: Compound Summary: Phthalic anhydride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Phthalic-anhydride. HERO ID: 6592047 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured or 1 1 1 estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / High The methodology for 1 1 1 Reliability Unbiased (Method producing the Objectivity) information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases Medium The data are from a 2 1 2 source that is known but is missing elements required for High designation such as peer-review, public availability, or the inclusion of references to original sources. Models Not rated Rating of this factor is NR NR NR not applicable to this kind of information. Sum of scores: 7 5 7

High Medium Low Overall Score = Sum 1.4 Overall 1.4

73 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Vapor Density reported by this reference. Cited reference: National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.

74 Study O'Neil, MJ. (2013). The Merck Index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Reference: Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Low The information is 3 1 3 not consistent with other measured data for the chemical. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 9 5 9 High Medium Low Overall Score = Sum 1.8 Overall 1.8 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference. Cited reference: O'Neil, M.J. (Ed.). 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry. P. 1786.

75 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

76 Cited reference: PhysProp. Horvath et al. 1999 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

77 The reviewer agreed with the overall rating for the Water Solubility reported by this reference. Cited reference: Horvath, A.L. et al. 1999. J Phys Chem Ref Data 28: 395-627.

78 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that references a peer- reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

79 The reviewer agreed with the overall rating for the Water Solubility reported by this reference. Cited reference: NIOSH

80 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

81 Cited reference: Wright; Schaffer; American journal of hygiene; vol. 16; (1932); p. 330 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Reference: Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

82 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Reference: Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

83 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Reference: Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a peer- 1 1 1 reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

84 Study Mueller, M; Klein, W. (1992). Comparative evaluation of methods predicting water Reference: solubility for organic compounds. Chemosphere 25: 769-782. http://dx.doi.org/10.1016/0045- 6535(92)90067-2. HERO ID: 654554 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Medium Calculated data 2 1 2 consistent with the subject chemical substance structural features. Test Reliability / High The 1 1 1 Reliability Unbiased (Method methodology for Objectivity) producing the information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Models High The model had a 1 1 1 defined, unambiguous endpoint and the model performance was known. Sum of scores: 5 4 5

85 High Medium Low Overall Score = 1.25 Overall 1.25 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

86 Study Nirmalakhandan, NN; Speece, RE. (1988). Prediction of aqueous solubility of organic chemicals Reference: based on molecular structure. Environ Sci Technol 22: 328-338. http://dx.doi.org/10.1021/es00168a014. HERO ID: 654558 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured or 1 1 1 estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical substance structural features or other physical/chemical properties or behaviors. Test Reliability / Unbiased Medium There is no indication 2 1 2 Reliability (Method Objectivity) that the methodology for producing the information was biased towards a particular product or outcome. Reliability / Analytical Medium the analytical method 2 1 2 Method is unknown but is likely to be appropriate Other Databases Not rated Rating of this factor is NR NR NR not applicable to this kind of information. Models Not rated Rating of this factor is NR NR NR not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low 1.5 Overall Score 1.5 (Rounded): Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference. Cited reference: Horvath, A.L., 1982. Halogenated Hydrocarbons., NY: Dekker

87 Study Wright, DA; Sandler, SI; Devoll, D. (1992). Infinite dilution activity coefficients and solubilities of Reference: halogenated hydrocarbons in water at ambient temperatures. Environ Sci Technol 26: 1828- 1831. http://dx.doi.org/https://pubs.acs.org/doi/pdf/10.1021/es00033a018. HERO ID: 658886 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance Appropriateness High Measured data are 1 1 1 consistent with the subject chemical substance structural features (e.g., presence of certain functional groups) and other physical/chemical properties Test Reliability / Unbiased Medium Study provided 2 1 2 Reliability (Method Objectivity) theory, method, analysis, and reference values. Reliability / Analytical Medium The analytical 2 1 2 Method method is non- standard but is expected to be appropriate Other Databases Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Water Solubility reported by this reference.

88

Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information Reference: for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured or 1 1 1 estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Unbiased Medium There is no 2 1 2 Reliability (Method Objectivity) indication that the methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that references peer- reviewed original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

89 The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference. Cited reference: PhysProp. Hansch, C et al. 1995

90 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to a peer-reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

91 The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference. Cited reference: NITE. 2014. Chemical Risk Information Platform (CHRIP). Biodegradation and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval.

92 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to a peer-reviewed source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

93 The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference. Cited reference: Hansch, C. Leo, A., Hoekman, D. 1995. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society, p. 4.

94 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with references to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

95 The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference. Cited reference: Broderius, Steven J.; Kahl, Michael D.; Hoglund, Marilynn D.; Environ Toxicol Chemistry; vol. 14; nb. 9; (1995); p. 1591 - 1606

96 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Octanol water partition Reference: coefficients (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932746 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 recognized, peer- reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.

97

Study Mueller, M; Klein, W. (1992). Comparative evaluation of methods predicting water Reference: solubility for organic compounds. Chemosphere 25: 769-782. http://dx.doi.org/10.1016/0045- 6535(92)90067-2. HERO ID: 654554 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Medium Calculated data 2 1 2 consistent with the subject chemical substance structural features. Test Reliability / High The 1 1 1 Reliability Unbiased (Method methodology for Objectivity) producing the information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / Not rated Rating of this NR NR NR Analytical Method factor is not applicable to this kind of information. Other Databases Not rated This matrix is not NR NR NR applicable to this calculated data. Models High The model had a 1 1 1 defined, unambiguous endpoint and the model performance was known. Sum of scores: 5 4 5

98 High Medium Low Overall Score = 1.2 Overall 1.2 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Octanol Water Coefficient (logKow) reported by this reference.

99 Study U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Reference: Information for 1,1,2-Trichloroethane. 79-00-5. HERO ID: 5926138 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Henry’s Law Constant reported by this reference.

100 Cited reference: PhysProp. Leighton, DTJR and Calo, JM 1981 J Chem Eng 26: 382-5.

101 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method 2 1 2 Analytical Method is unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available database that provides references to original sources. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = 1.4 Overall 1.4 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Henry’s Law Constant reported by this reference.

102 Cited reference: Leighton, D.T., Calo, J.M. 1981. J Chem Eng 26: 382-5.

103 Study Rumble, JR. (2018). CRC Handbook of Chemistry and Physics. Aqueous solubility and Reference: Henry's law constants of organic compounds (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5932745 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness High Measured data are 1 1 1 consistent with the subject chemical's physical/chemical properties. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 recognized, peer- reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 7 5 7 High Medium Low Overall Score = Sum 1.4 Overall 1.4 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Henry’s Law Constant reported by this reference.

104

Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR 1 NR factor is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 8 4 8

105 High Medium Low Overall Score = 2 Overall 2 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Flash Point reported by this reference. Cited reference: SynQuest

106 Study Dreher, EL; Beutel, KK; Myers, JD; Lübbe, T; Krieger, S; Pottenger, LH. (2014). Chloroethanes Reference: and chloroethylenes. In B Elvers (Ed.), Ullmann's Encyclopedia of Industrial Chemistry (6th ed., pp. 1-81). Hoboken, NJ: Wiley‐VCH Verlag GmbH & Co. http://dx.doi.org/10.1002/14356007.o06_o01.pub2. HERO ID: 4293766 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a known 1 1 1 data- collection, prepared by experts in the field. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

107 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Autoflammability reported by this reference.

108 Study Rumble, JR. (2018). Flammability of chemical substances. In CRC Handbook of Chemistry and Reference: Physics (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 6655446 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a known 1 1 1 data- collection, prepared by experts in the field. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High

≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3

109 Quality Level: The reviewer agreed with the overall rating for the Autoflammability reported by this reference.

110 Study Sathyanarayana, B; Ranjithkumar, B; Jyostna, TS; Satyanarayana, N. (2007). Densities Reference: and viscosities of binary liquid mixtures of N-methylacetamide with some chloroethanes and chloroethenes at T=308.15 K. The Journal of Chemical Thermodynamics 39: 16-21. http://dx.doi.org/10.1016/j.jct.2006.06.009. HERO ID: 4698408 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / High The 1 1 1 Reliability Unbiased (Method methodology for Objectivity) producing the information is designed to answer a specific question, and the methodology’s objective is clear. Reliability / High Data are 1 1 1 Analytical Method obtained by accepted standard analytical methods, including, but not limited to OECD guidelines for physical- chemical properties or other developed standard. Other Databases Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information.

111 Sum of scores: 3 3 3 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Viscosity reported by this reference.

112 Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to a recognized data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

113 The reviewer agreed with the overall rating for the Viscosity reported by this reference. Cited reference: Kirk-Othmer Encyclopedia of Chemical Technology. 1993. 4th Ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-present. P. V6: 23.

114 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Viscosity reported by this reference. Cited reference: Data range determined from multiple primary sources in REAXYS.

115

Study O'Neil, MJ. (2013). The Merck index. 1,1,2-Trichloroethane. 79-00-5 (15th ed.). Reference: Cambridge, UK: Royal Society of Chemistry. HERO ID: 5330121 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to a recognized data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

116 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Refractive Index reported by this reference. Cited reference: O'Neil, M.J. (Ed.). 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry. P. 1786.

117

Study NLM. (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5 Reference: [Website]. https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB. HERO ID: 5926162 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 publicly available, peer-reviewed database that provides references to a recognized data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

118 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Refractive Index reported by this reference. Cited reference: O'Neil, M.J. (Ed.) 2013. The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc. 2006. p. 1656.

119 Study RSC. (2019). ChemSpider: 1,1,2-Trichloroethane [Website]. Reference: http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6- 4138-93e0- 67641f978a2c. HERO ID: 5926271 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are 1 1 1 measured or estimated for the subject chemical substance. Appropriateness Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that Objectivity) the methodology for producing the information was biased towards a particular product or outcome. Reliability / Low The analytical 3 1 3 Analytical Method method is unknown and there is no indication that a reliable method was used. Other Databases Medium Data is from a 2 1 2 publicly available secondary source with references to non-peer reviewed sources. Models Not rated Rating of this NR NR NR factor is not applicable to this kind of information. Sum of scores: 8 4 8

120 High Medium Low Overall Score = 2 Overall 2 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall Medium Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Refractive Index reported by this reference. Cited reference: SynQuest

121 Study Rumble, JR. (2018). CRC handbook of chemistry and physics. 1,1,2-Trichloroethane. Reference: Boca Raton, FL: CRC Press. Taylor & Francis Group. HERO ID: 5926365 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 or estimated for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 recognized, peer- reviewed data collection. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6 High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Refractive Index reported by this reference.

122

Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

123 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: Laurence, Christian; Nicolet, Pierre; Dalati, M. Tawfik; Abboud, Jose-Luis M.; Notario, Rafael; Journal of Physical Chemistry; vol. 98; nb. 23; (1994); p. 5807 - 5816.

124

Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

125 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: Viguera, Jesus; Valero, Jose; Gracia, Mariano; Losa, Gutierrez Celso; Journal de Chimie Physique et de Physico-Chimie Biologique; vol. 78; nb. 2; (1981); p. 149 - 154.

126

Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

127 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: van Braam Houckgeest; Recueil des Travaux Chimiques des Pays-Bas; vol. 60; (1941); p. 435.

128 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognized database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = Sum 1.5 Overall 1.5 of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors: Overall High

≥1 and ≥1.7 and <2.3 ≥2.3 and ≤3

129 Quality Level: The<1.7 reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: Crowe; Smyth; Journal of the American Chemical Society; vol. 72; (1950); p. 4009,4010.

130

Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

131 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: Crowe; Smyth; Journal of the American Chemical Society; vol. 72; (1950); p. 4009,4010.

132 Study Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Reference: Registry Number: 79-00-5 [Website]. HERO ID: 5926430 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness High Data are measured 1 1 1 for the subject chemical substance. Appropriateness Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Test Reliability / Medium There is no 2 1 2 Reliability Unbiased (Method indication that the Objectivity) methodology for producing the information was biased towards a particular product or outcome. Reliability / Medium Analytical method is 2 1 2 Analytical Method unknown but is likely to be appropriate based on the data’s inclusion in a peer- reviewed/recognize d database or other secondary source. Other Databases High Data is from a 1 1 1 secondary database with a reference to the peer-reviewed original source. Models Not rated Rating of this factor NR NR NR is not applicable to this kind of information. Sum of scores: 6 4 6

High Medium Low Overall Score = 1.5 Overall 1.5 Sum of Weighted Score Scores/Sum of (Rounded): Metric Weighting Factors:

133 Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level: The reviewer agreed with the overall rating for the Dielectric Constant reported by this reference. Cited reference: Timmermans et al.; Bulletin des Societes Chimiques Belges; vol. 64; (1955); p. 5,19; Timmermans; Hennaut-Roland; Journal de Chimie Physique et de Physico-Chimie Biologique; vol. 52; (1955); p. 223,228.

134 Study U.S. EPA (U.S. Environmental Protection Agency). (2012). Estimation Programs Reference: Interface Suite™ for Microsoft® Windows, v 4.11 [Computer Program]. Washington, DC. Retrieved from https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation- program-interface. HERO ID: 2347246 Domain Metric Qualitative Comments Metric Metric Weighted Determination Score Weighting Score [i.e., High, Factor Medium, Low, Unacceptable, or Not rated] Substance Representativeness Not rated The metric is NR 1 NR not applicable to this study type (SAR). Appropriateness Not rated The metric is NR 1 NR not applicable to this study type (SAR). Test Reliability / Not rated The metric is NR 1 NR Reliability Unbiased (Method not applicable Objectivity) to this study type (SAR). Reliability / Not rated The metric is NR 1 NR Analytical Method not applicable to this study type (SAR). Other Databases Not rated The metric is NR 1 NR not applicable to this study type (SAR). Models High The models in 1 1 1 EPI SuiteTM have defined endpoints. Chemical domain and performance statistics for each model are known, and unambiguous algorithms are available in the EPI SuiteTM documentation and/or cited references to establish their scientific validity. Many EPI SuiteTM models have correlation

135 coefficients >0.7, cross- validated correlation coefficients >0.5, and standard error

however, correlationvalues <0.3; coefficients (r2, q2) for the regressions of some environmental fate models (i.e. BIOWIN) are lower, as expected, compared to regressions which have specific experimental values such as water solubility or log Kow (octanol-water partition coefficient). Sum of scores: 1 1 1 High Medium Low Overall Score = 1 Overall 1 Sum of Score Weighted (Rounded): Scores/Sum of Metric Weighting Factors: Overall High Quality ≥1 and <1.7 ≥1.7 and <2.3 ≥2.3 and ≤3 Level:

References

Dreher, EL; Beutel, KK; Myers, JD; Lübbe, T; Krieger, S; Pottenger, LH. (2014). Chloroethanes and chloroethylenes. In B Elvers (Ed.), Ullmann's Encyclopedia of Industrial Chemistry (6th ed., pp. 1- 81). Hoboken, NJ: Wiley‐VCH Verlag GmbH & Co. http://dx.doi.org/10.1002/14356007.o06_o01.pub2 Elsevier. (2019). Reaxys: physical-chemical property data for 1,1,2-trichloroethane. CAS Registry Number: 79-00-5. Available online

136 Mueller, M; Klein, W. (1992). Comparative evaluation of methods predicting water solubility for organic compounds. Chemosphere 25: 769-782. http://dx.doi.org/10.1016/0045-6535(92)90067-2 Nirmalakhandan, NN; Speece, RE. (1988). Prediction of aqueous solubility of organic chemicals based on molecular structure. Environ Sci Technol 22: 328-338. http://dx.doi.org/10.1021/es00168a014 NLM (National Institutes of Health, National Library of Medicine). (2018). PubChem: Hazardous Substance Data Bank: 1,1,2-Trichloroethane, 79-00-5. Available online at https://pubchem.ncbi.nlm.nih.gov/compound/6574#source=HSDB NLM (National Institutes of Health, National Library of Medicine). (2020). PubChem database: compound summary: 1,1,2-trichloroethane. Available online at https://pubchem.ncbi.nlm.nih.gov/compound/1_1_2-Trichloroethane O'Neil, MJ. (2013). 1,1,2-Trichloroethane. 79-00-5. In The Merck index (15th ed.). Cambridge, UK: Royal Society of Chemistry. RSC (Royal Society of Chemistry). (2019). ChemSpider: 1,1,2-Trichloroethane. Available online at http://www.chemspider.com/Chemical-Structure.6326.html?rid=2a2c9061-8bb6-4138-93e0- 67641f978a2c Rumble, JR. (2018a). Aqueous solubility and Henry's law constants of organic compounds. In CRC Handbook of Chemistry and Physics (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. Rumble, JR. (2018b). Flammability of chemical substances. In CRC Handbook of Chemistry and Physics (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. Rumble, JR. (2018c). Octanol-water partition coefficients. In CRC Handbook of Chemistry and Physics (99 ed.). Boca Raton, FL: CRC Press. Taylor & Francis Group. Rumble, JR, (Ed.). (2018d). 1,1,2-Trichloroethane. In CRC handbook of chemistry and physics. Boca Raton, FL: CRC Press. Taylor & Francis Group. Sathyanarayana, B; Jyostna, TS; Satyanarayana, N. (2006). Acoustic studies of binary mixtures of N- methylacetamide with some chloroethanes and chloroethenes at 308.15 K. Indian J Pure Appl Phys 44: 587-591. Sathyanarayana, B; Ranjithkumar, B; Jyostna, TS; Satyanarayana, N. (2007). Densities and viscosities of binary liquid mixtures of N-methylacetamide with some chloroethanes and chloroethenes at T=308.15 K. The Journal of Chemical Thermodynamics 39: 16-21. http://dx.doi.org/10.1016/j.jct.2006.06.009 U.S. EPA (U.S. Environmental Protection Agency). (2012). Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.11. Washington, DC. https://www.epa.gov/tsca-screening-tools/epi- suitetm-estimation-program-interface U.S. EPA (U.S. Environmental Protection Agency). (2019). Chemistry Dashboard Information for 1,1,2- Trichloroethane. 79-00-5. Available online at https://comptox.epa.gov/dashboard/dsstoxdb/results?search=DTXSID5021380 Wright, DA; Sandler, SI; Devoll, D. (1992). Infinite dilution activity coefficients and solubilities of halogenated hydrocarbons in water at ambient temperatures. Environ Sci Technol 26: 1828- 1831. http://dx.doi.org/https://pubs.acs.org/doi/pdf/10.1021/es00033a018 Yalkowsky, SH; Mishra, DS. (1991). Vapor pressure estimation for organic compounds. Sci Total Environ 109-110: 243-250. http://dx.doi.org/10.1016/0048-9697(91)90181-D

137