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Full Paper In SUPPLEMENT 1 27(S1) Volume 27 Number 1 February 2021 Hong Kong The official publication of the HONG KONG MEDICAL JOURNAL Hong Kong Academy of Medicine and edical the Hong Kong Medical Association M ournal J Volume 27 Number 1 February Volume 2021 26th MEDICAL RESEARCH CONFERENCE Department of Medicine The University of Hong Kong Queen Mary Hospital, Hong Kong 16 January 2021 Supplement 1 ISSN 1024-2708 Volume 27 Number 1 February 2021 SUPPLEMENT 1 EDITOR-IN-CHIEF 26th Medical Research Conference, 16 January 2021 Martin CS Wong 黃至生 SENIOR EDITORS Department of Medicine, The University of Hong Kong, Queen LW Chu 朱亮榮 Mary Hospital, Hong Kong Albert KK Chui 徐家強 Michael G Irwin Bonnie CH Kwan 關清霞 ABSTRACT TITLE PAGE Eric CH Lai 賴俊雄 KY Leung 梁國賢 1 Clinical characteristics in patients with non-cystic fibrosis 8 Anthony CF Ng 吳志輝 bronchiectasis and co-existing airway diseases in Chinese EDITORS population KS Chan 陳健生 WC Kwok, JCM Ho, TCC Tam, MSM Ip, DCL Lam Sherry KW Chan 陳喆燁 Jason PY Cheung 鍾培言 2 Territory-wide epidemiology and sensitisation patterns of 8 Kelvin KL Chong 莊金隆 Velda LY Chow 周令宇 beta-lactam allergy in Hong Kong Jacqueline PW Chung 鍾佩樺 PH Li, HHF Yeung, CS Lau, EYL Au Brian SH Ho 何思灝 Ellis KL Hon 韓錦倫 3 Prevalence of mild behavioural impairment: a systematic 9 Junjie Huang 黃俊杰 review and meta-analysis KW Huang 黃凱文 WK Hung 熊維嘉 Y Pan, YF Shea, S Li, R Chen, HKF Mak, PKC Chiu, LW Chu, YQ Song Ho Lam 林 賀 4 First report of pathogenic mutations and complete C6 9 Arthur CW Lau 劉俊穎 PY Lau 婁培友 deficiency in Chinese pedigree Danny WH Lee 李偉雄 JMH Li, PH Li Thomas WH Leung 梁慧康 WK Leung 梁惠強 5 Statins associated with better clinical outcomes in patients 10 Kenneth KW Li 李啟煌 achieving HBsAg seroclearance: a long-term follow-up study Janice YC Lo 羅懿之 Herbert HF Loong 龍浩鋒 KS Cheung, LY Mak, J Fung, F Liu, WK Seto, MF Yuen Rashid Lui 雷諾信 James KH Luk 陸嘉熙 6 Neurosensory rehabilitation and olfactory network recovery 10 Arthur DP Mak 麥敦平 in coronavirus disease 2019–related olfactory dysfunction Henry KF Mak 麥嘉豐 TWH Chung, H Zhang, FKC Wong, S Sridhar, KH Chan, VCC Cheng, Martin W Pak 白 威 KY Yuen, IFN Hung, HKF Mak Walter WK Seto 司徒偉基 Regina WS Sit 薛詠珊 7 Piperacillin-tazobactam allergies: an exception to usual 11 Jeremy YC Teoh 張源津 KY Tse 謝嘉瑜 penicillin allergy Harry HX Wang 王皓翔 CYJ Wong, PH Li HL Wong 黃學良 Kenneth KY Wong 黃格元 8 Identification of a novel therapeutic target for cerebral 11 Patrick CY Woo 胡釗逸 ischaemia injury: role of branched chain amino acids Hao Xue 薜 浩 Jason CS Yam 任卓昇 catabolism in ischaemic stroke Bryan PY Yan 甄秉言 B Liao, L Geng, RLC Hoo, A Xu TK Yau 游子覺 Kelvin KH Yiu 姚啟恒 9 Associations of seasonal variations and meteorological 12 Vivian MY Yuen 袁文英 parameters with incidences of upper and lower EPIDEMIOLOGY ADVISERS gastrointestinal bleeding in older adults Daniel SY Ho 何世賢 Eman Leung 梁以文 CG Guo, L Tian, F Zhang, KS Cheung, WK Leung Edmond SK Ma 馬紹強 Gary Tse 謝家偉 10 Impact of childhood pneumococcal conjugate vaccine 12 Shelly LA Tse 謝立亞 immunisation on all-cause pneumonia admissions: a 14-year Ian YH Wong 王逸軒 population-based interrupted time series analysis Esther YT Yu 余懿德 Hunter KL Yuen 袁國禮 QY Yu, X Li, M Fan, LW Tian, CSL Chui, PH Li, LKW Lau, EW Chan, P Ip, STATISTICAL ADVISERS TY Lum, IFN Hung, BJ Cowling, ICK Wong Marc KC Chong 莊家俊 William B Goggins Eddy KF Lam 林國輝 Carlos KH Wong 黃競浩 HONORARY ADVISERS David VK Chao 周偉強 Paul BS Lai 賴寶山 Hong Kong Med J ⎥ Volume 27 Number 1 (Supplement 1) ⎥ February 2021 ⎥ www.hkmj.org 1 INTERNATIONAL EDITORIAL ABSTRACT TITLE PAGE ADVISORY BOARD 11 Tumour suppressive role of sirtuin 4 in induction of G2/M 13 Sabaratnam Arulkumaran arrest and apoptosis in HBV-related hepatocellular carcinoma United Kingdom FY Huang, DKH Wong, WK Seto, LY Mak, MF Yuen Robert Atkins Australia 12 Novel role of GDF15 in non-alcoholic steatohepatitis 13 Peter Cameron X Yan, Z Huang, R Yang, L Xu, A Xu Australia 13 Comparative effectiveness on remission, risk of Graves’ 14 Daniel KY Chan ophthalmopathy and hypothyroidism of treatments for Australia Graves’ diseases: a systematic review and network David Christiani United States meta-analysis X Liu, CKH Wong, Y Wei, WWL Chan, YC Woo, CLK Lam, BHH Lang Andrew Coats Australia 14 Thyroid dysfunction in relation to immune profile, viral load, 14 James Dickinson disease status and outcome in 191 patients with COVID-19 Canada DTW Lui, CH Lee, WS Chow, ACH Lee, AR Tam, CHY Fong, CY Law, Willard Fee, Jr EKH Leung, KKW To, KCB Tan, YC Woo, CW Lam, IFN Hung, KSL Lam United States 15 Predicting incident hip fractures in Chinese type 2 diabetic 15 Robert Hoffman United States individuals using A to G’S DTW Lui, CH Lee, WS Chow, CHY Fong, DCW Siu, YC Woo, KSL Lam Michael Kidd Australia 16 Machine learning model in predicting the minimal endoscopy 15 Arthur Kleinman services requirement for gastrointestinal cancer diagnosis in United States Hong Kong during various phases of COVID-19 Stephen Leeder TKL Lui, WK Leung Australia 17 Aspirin use and risk of colorectal cancer among older adults 16 Xiaoping Luo PR China CG Guo, W Ma, WK Leung, AT Chan William Rawlinson 18 Trends in cardiovascular risk in the United States 1999 to 16 Australia 2018 Jonathan Samet HL Li, BMY Cheung United States 19 Obesity is a major risk factor for severe COVID-19 illness 17 Yaojiang Shi HL Li, BMY Cheung PR China David Weller 20 Aspirin is associated with higher mortality in patients with 17 United Kingdom infective endocarditis Max Wintermark HL Li, SSY Yu, PF Wong, ASY Yu, YK Tse, LY Lam, CKY Leung, KY Li, MZ Wu, United States QW Ren, KH Yiu Wanghong Xu 21 Apabetalone reduces cardiovascular risk: a meta-analysis 18 PR China HL Li, Y Fei, BMY Cheung Atsuyuki Yamataka Japan 22 Prevalence of childhood obesity in the United States 1999 to 18 Homer Yang 2018: a 20-year analysis Canada HL Li, MF Tsoi, Q Feng, CL Cheung, TT Cheung, BMY Cheung KG Yeoh 23 Outcomes and microbiology in patients with infective 19 Singapore endocarditis in Hong Kong 1996 to 2019 Zhijie Zheng HL Li, SSY Yu, PF Wong, ASY Yu, YK Tse, LY Lam, MZ Wu, QW Ren, KH Yiu PR China 24 Factors associated with sleep apnoea prevalence in patients 19 with stroke: a systematic review and meta-analysis Full details of the Editorial Board are available online at XD Liu, DCL Lam, HY Chan, MSM Ip, GKK Lau https://www.hkmj.org/about/eo.html 26 Pilot study of smartphone-based applications in assessing 20 motor and gait disability in Parkinson’s disease MANAGING EDITOR KK Yam, SYY Pang, SL Ho Alan Purvis DEPUTY MANAGING EDITOR Betty Lau 劉薇薇 ASSISTANT MANAGING EDITOR Warren Chan 陳俊華 2 Hong Kong Med J ⎥ Volume 27 Number 1 (Supplement 1) ⎥ February 2021 ⎥ www.hkmj.org ABSTRACT TITLE PAGE 27 Reduced hepatic steatosis is associated with higher risk of hepatocellular carcinoma in 21 chronic hepatitis B infection LY Mak, RWH Hui, J Fung, F Liu, DKH Wong, KS Cheung, MF Yuen, WK Seto 28 Persistently detectable serum HBV DNA and HBV pgRNA is associated with hepatocellular 21 carcinoma development in chronic hepatitis B patients receiving long-term nucleoside analogue therapy LY Mak, Q Huang, DKH Wong, LM Stamm, KS Cheung, KL Ko, R Yan, L Ouyang, J Fung, WK Seto, MF Yuen 29 PAR-1 antagonist vorapaxar protects against kidney injury and tubulointerstitial fibrosis in 22 the progression of acute kidney injury to chronic kidney disease SWY Lok, WH Yiu, LYY Chan, JCK Leung, KN Lai, SCW Tang 30 Intractable hypoglycaemia induced by the antibody against exogenous insulin in a Chinese 22 patient with type 1 diabetes L Geng, X Diao, X Zhao, J Yu, Y Chen, W Liang, A Xu 31 Shifts in gut antibiotic resistance genes after the exposure to different H pylori eradication 23 therapies LL Wang, HB Yao, T Tong, KS Lau, A Chan, JWK Ho, SY Leung, WK Leung 32 Delineating interferon-alpha mediated AIM2 inflammasome response in systemic lupus 23 erythematosus JX Chow, CS Lau, VSF Chan 33 Dysregulation of interleukin-18 receptor accessory protein in neutrophils of patients with 24 systemic lupus erythematosus J Ma, IKY Lam, CS Lau, VSF Chan 34 Haploidentical haematopoietic stem cell transplant outcomes from Queen Mary Hospital 24 YZ Ng, JPY Sim, AKW Lie, YL Kwong 35 Lactococcus lactis as a faecal biomarker predicting the development of non-alcoholic fatty 25 liver disease: evidence from a human microbiota-associated rodent model S Zhang, HM Tun, CH Lee, HT Chau, D Zhang, S Liang, FY Huang, DKH Wong, KSL Lam, MF Yuen, WK Seto 36 Thyroid immune-related adverse events in cancer patients treated with anti-PD1/anti-CTLA4 25 immune-checkpoint inhibitor combination: clinical course and outcomes DTW Lui, CH Lee, V Tang, CHY Fong, ACH Lee, JWY Chiu, RCY Leung, GGW Kwok, BCW Li, TT Cheung, YC Woo, KSL Lam, T Yau 37 Soluble interleukin-6 receptor determines exercise responsiveness in term of insulin 26 sensitivity and glycaemic control Y Wang, JM Wu, Y Liu, AM Xu 38 Adipocyte-derived lactate potentiates obesity-evoked adipose macrophage inflammation 26 TS Feng, AM Xu, HXY Hui 39 Long-term pharmacological inhibition of mutant leucine-rich repeat kinase 2 hyperactivity 27 reduced alpha-synuclein serine-129 phosphorylation and oligomer levels in mouse brains EES Chang, HF Liu, CT Leung, Y Malki, YK Choi, SYY Pang, PWL Ho, SL Ho 40 Clinical outcome following percutaneous coronary intervention in stable coronary artery 27 disease based on a novel index: computational pressure-flow dynamics derived fractional flow reserve LY Lam, CKL Leung, KY Li, ASY Yu, MZ Wu, QW Ren, PF Wong, YK Tse, SSY Yu, HL Li, KH Yiu 41 Pioglitazone ameliorates motor impairments and spinal cord pathologies in a mouse model
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