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SYSTEMIC DISORDERS AFFECTING DENTAL PATHOLOGY 249 Be Associated to Dental Discoloration

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SYSTEMIC DISORDERS AFFECTING DENTAL PATHOLOGY 249 Be Associated to Dental Discoloration UDK: 616.31-02 2014; 9(3): 247–251 ID: 212448012 ISSN-1452-662X Revijalni rad SYSTEMIC DISORDERS AFFECTING DENTALPATHOLOGY Knezevic R. Milan,1 Andjelic S. Gordana,2 Knezevic M. Milena3 1 FEBOMFS, University Las Palmas, Spain 2 Institute for Medical Research, Military Medical Academy, Belgrade, Serbia 3 Medical School, University Las Palmas, Spain Primljen/Received 20. 10. 2014. god. Prihva}en/Accepted 08. 12. 2014. god. Abstract: A retrospective overview of systemic substances, chromosomal anomalies, infections, here- disorders which might be associated with dental patho- ditary diseases, malnutrition, metabolic alterations and logy is made. They are grouped as follows: (a) congen- neurological disorders. In contrast, Wright (2) descri- ital dental developmental disorders, (b) chromosomal bes only three etiological groups: metabolic diseases, anomalies, (c) radiations, (d) immune disorders, (e) in- syndromic hereditary disorders and nonsyndromic he- toxications, (f) neurological alterations, (g) gastrointe- reditary disorders (e.g., amelo génesis imperfecta and stinal diseases, (h) osteodystrophy and associated con- other enamel developmental disorders). As commen- ditions, (i) skin diseases, (j) metabolic and endocrine ted above, the classification or grouping of the differ- disorders, (k) craniofacial malformation syndromes ent diseases poses difficultness — particularly when and other congenital general malformations. The asso- referring to congenital disorders. In this context, it is ciated dental pathology is described in each case. accepted that in addition to the etiological factors asso- Key words: Dental diseases, Symptoms, Systemic ciated to the dental anomalies described below, other disease, Retrospective overview. underlying factors — probably genetic, related to tooth development and individual resistance to disease — INTRODUCTION are also implicated (3). Dental pathology may be divided into five etiolo- CONGENITAL ALTERATIONS gical groups /1/ infections (e.g., caries) /2/, trauma- OF TOOTH DEVELOPMENT tisms /3/, disorders resulting from dental wear (e.g., at- trition, erosion, and abrasion) /4/, pathologic formati- In this first group of dental disorders associated to ons /5/ and dental developmental disorders — the latter systemic pathology, mention should be made of tauro- usually being associated to other extra oral clinical ma- dontism, characterized by the presence of large pulp nifestations that may or may not form part of a com- chambers that can occupy the entire root. This dental mon syndrome. condition is associated to the trichodentoosseous Many diseases and pathological conditions, invol- (TDO) syndrome, hypohidronic ectodermal dysplasia ving practically all human apparatuses and systems, and Klinefelter’s syndrome (4). All pacients with TDO exhibit associated dental pathology or manifestations. syndrome present this malformation (5); in contrast, it The present study reviews those systemic disorders is only observed in certain hypo maturate variants of that may associate dental pathology, grouped as shown amelogenesis imperfecta (6). This marked association below. The grouping of such systemic diseases into ca- between both entities suggests the existence of a gene- tegories is complicated; however, since group overlap- tic determining characteristic referred to as idiopathic ping inevitably occurs. On reviewing the etiologies of dental fluorosis (4). On the other hand, 28.9% of paents dental disorders, no uniform classification criteria are with oligodontia suffer taurodontism of one or more, to be found among the different authors who have ad- lower molars, with greatly diminished length of the dressed the subject. As an example, in the case of mor- mandibular cuspids and first molars in women (7). In phology — structural dental enamel defects, Neville et turn, the hypoplastic form of amelogenesis imperfecta al. (1) propose an exhaustive classification comprising can manifest in combination with multiple unerupted trauma to developing tissues, the ingestion of chemical teeth, hypercementosis and different root malformati- 248 Knezevic R. Milan, Andjelic S. Gordana, Knezevic M. Milena ons (8). In animals - specifically, in mice with transge- proportion being approximately the same as internals nic cystic fibrosis (9) — anomalies have been observed with a 45, X karyotype (22). in the form of soft whitish-blue enamel together with enamel of normal thickness and structure; ameloblasts RADIATIONS that rapidly degenerate after the secretory phase, and enamel crystals of granular appearance and low mole- Radiotherapy for head and neck cancer produces cular weight. symptoms such as mucositis, oral dryness and taste al- In the case of odontodysplasia associated to ecto- terations (23). A consequence of xerostomia is the in- dermal dysplasia, clinical manifestations such as hypo- creased risk of caries, which in these patients tend to be dontia and hypoplastic enamel appear (10). rapidly evolving, extensive and located in non-habitual zones (24). In children receiving radio-and chemother- Dentinogenesis imperfecta associated to osteoge- apy, the number of dental anomalies has been found to nesis imperfecta constitutes a structural anomaly affec- increase (25). ting only the dentine. The teeth appear normal, though their development is abnormal (11); alterations in den- tine formation occur in such cases (12). In experimen- INTOXICATIONS tal studies in rats, cyclosporine A has been shown to af- Dental pathology associated to drug ingestion is fect dentine formation, with alterations in the amount diverse (26). As regards the production of caries, three of secondary dentine appositioning and the generation groups of drugs can be cited: (a) those containing sac- of globular dental structures; the pulp is also affected in charose as excipient; (b) drugs that depress salivation such situations (13). and there-fore reduce the action of salivary caryopro- phylactic agents in general (ie., buffer systems, dilu- CHROMOSOMAL ANOMALIES tion effect, etc.) — including tricyclic antidepressants, antipsychotic drugs, antihistamines, medication for ar- Turner’s syndrome involves morphological and thritis, analgesics, diuretics, muscle relaxants, antia- volumetric dental alterations, with root abnormalities rrhythmic drugs, anticonvulsive agents, antidiarrhea in lower molars and premolars, and reductions in size; formulations, antihypertensive drugs, medication for the coronal portions of the incisors, canines and pre- Parkinson’s disease, antispasmodic drugs, anorexige- molars are also affected (14), and the mesio-distal dia- nic agents; and (c) lithium-containing drugs. Drug in- meters are reduced (except in the upper canines) along toxications can also cause dental discoloration, e.g., to- with the vestibule lingual diameter of some teeth only pical tin fluoride and systemically administered flours, (15). In Down syndrome the frequency of agenesis is chlorhexidine (though in this concrete case the dental 10 times greater than in the general population, with a plaque rather than the actual dental structure is stai- higher incidence in males than in females. In order of ned), tetracyclines and ciprofloxacin. Regarding morp- descending frequency, agenesis affects the maxillary ho-structural alterations of teeth, phenytoin should be central incisors, the maxillary lateral incisors, the ma- mentioned, as it produces shortening, resorption and xillary second premolars, and the mandibular second increased cement deposisitioning turn; local anesthet- premolars (16). Microdontia is also observed. Another ics are cytotoxic for tooth enamel and can interfere trisomy-involving chromosome 16 , is also associated with amelogenesis when introduced under pressure in- to dental alterations. In this sense, decreases in the size to deciduous tooth ligaments. Additionaly, they may of different dental organs have been documented in mi- cause enamel hypoplasias in permanent dentition. ce, together with the appearance of hypoplasias (17). Lastly, doxapram has been reported to induce the In one case of triple X syndrome the congenital pre-mature appearance of dental germs (27). absence of teeth was reported, with the presence of only one maxillary central incisor in both the deciduo- GASTROINTESTINAL DISEASES us and permanent dentition (18). Internals with a 45, XO karyotype, reductions in cuspid surface can be ob- One of the most frequent dental alterations is ero- served, along with decreases in volumenn -as reflec- sion associated to gastrointestinal disorders. An exam- tedby shortened mesiodistal and vestibulolingual dia- ple of this is provided by voluntary regurgitation (28), meters (19). Taurodontism has also been described where the acid gastric contents attack the dental surfa- (20). In Klinefelter’s syndrome (males 47, XXY), im- ce, causing progressive dental erosion (wear). In such portant increments in enamel (but not of dentine) have situations the patient suffers marked dental hard tissue been reported — in contrast to what is seen internals loss in the anterior group, and even in the palatine (lin- (21). As regards the gnostic condition 45, X/46, XX, gual) surfaces of the premolars — to the point of expo- 43% of the mandibular premolars have two roots — the sing the pulp chambers. These alterations may in turn SYSTEMIC DISORDERS AFFECTING DENTAL PATHOLOGY 249 be associated to dental discoloration. Similar effects pomatosis, with unilateral coronal enlargement or are observed in patients with gastro esophageal reflux, ma-crodontia,
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