DOCSLIB.ORG

Sample Page 1

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Sample Page 1 COMPARISON OF REPRESENTATIVE TOPICAL CORTICOSTEROID PREPARATIONS (CLASSIFIED ACCORDING TO THE US SYSTEM) COMPARISON OF REPRESENTATIVE TOPICAL CORTICOSTEROID PREPARATIONS (CLASSIFIED ACCORDING TO THE US SYSTEM) Available Strength(s), Potency groupa Corticosteroid Vehicle Type/Form Brand Names (United States) Percent (Except as Noted) Betamethasone dipropionate, Gel, lotion, ointment Diprolene 0.05 augmented (optimized) Cream, gel, ointment, solution Temovate 0.05 (scalp) Cream, emollient base Temovate E 0.05 Clobetasol propionate Lotion, shampoo, spray Clobex 0.05 aerosol Super-high potency (group 1) Foam aerosol Olux-E, Tovet 0.05 Solution (scalp) Cormax 0.05 Diflucortolone valerate (not Nerisone Forte (United Ointment, oily cream 0.3 available in United States) Kingdom, others) Fluocinonide Cream Vanos 0.1 Flurandrenolide Tape (roll) Cordran 4 mcg/cm2 Halobetasol propionate Cream, lotion, ointment Ultravate 0.05 Amcinonide Ointment Cyclocortb, Amcortb 0.1 Ointment Diprosoneb 0.05 Betamethasone dipropionate Cream, augmented Diprolene AF 0.05 formulation (AF) Clobetasol propionate Cream Impoyz 0.025 Cream, ointment, spray Topicort 0.25 High potency (group 2) Desoximetasone Gel Topicort 0.05 Ointment ApexiConb, Floroneb 0.05 Diflorasone diacetate Cream, emollient ApexiCon E 0.05 Fluocinonide Cream, gel, ointment, solution Lidexb 0.05 Halcinonide Cream, ointment, solution Halog 0.1 Halobetasol propionate Lotion Bryhali 0.01 Cream Cyclocortb, Amcortb 0.1 Amcinonide Lotion Amcortb 0.1 Betamethasone dipropionate Cream, hydrophilic emollient Diprosoneb 0.05 Ointment Valisoneb 0.1 Betamethasone valerate Foam Luxiq 0.12 Desoximetasone Cream Topicort LPb 0.05 b High potency (group 3) Diflorasone diacetate Cream Florone 0.05 Diflucortolone valerate (not Nerisone (Canada, United Cream, oily cream, ointment 0.1 available in United States) Kingdom, others) Fluocinonide Cream aqueous emollient Lidex-Eb 0.05 Fluticasone propionate Ointment Cutivate 0.005 Mometasone furoate Ointment Elocon 0.1 Aristocort HPb, Kenalogb, Triamcinolone acetonide Cream, ointment 0.5 Triderm Betamethasone dipropionate Spray Sernivo 0.05 Clocortolone pivalate Cream Cloderm 0.1 Fluocinolone acetonide Ointment Synalarb 0.025 Flurandrenolide Ointment Cordran 0.05 Hydrocortisone valerate Ointment Westcort 0.2 Medium potency (group 4) Mometasone furoate Cream, lotion, ointment, Eloconb 0.1 solution Cream Kenalogb, Triderm 0.1 Ointment Kenalogb 0.1 Triamcinolone acetonide Ointment Trianex 0.05 Aerosol spray Kenalog 0.2 mg per 2-second spray Dental paste Oralone 0.1 Betamethasone dipropionate Lotion Diprosoneb 0.05 Betamethasone valerate Cream Beta-Val, Valisoneb 0.1 Ointment DesOwen, Tridesilonb 0.05 Desonide Gel Desonate 0.05 Fluocinolone acetonide Cream Synalarb 0.025 Flurandrenolide Cream, lotion Cordran 0.05 Fluticasone propionate Cream, lotion Cutivate 0.05 Lower-mid potency (group 5) Cream, lotion, ointment, Hydrocortisone butyrate Locoid, Locoid Lipocream 0.1 solution Hydrocortisone probutate Cream Pandel 0.1 Hydrocortisone valerate Cream Westcortb 0.2 Prednicarbate Cream (emollient), ointment Dermatop 0.1 Lotion Kenalogb 0.1 Triamcinolone acetonide Ointment Kenalogb 0.025 Alclometasone dipropionate Cream, ointment Aclovate 0.05 Betamethasone valerate Lotion Beta-Valb, Valisoneb 0.1 Cream DesOwen, Tridesilonb 0.05 Desonide Lotion DesOwen, LoKara 0.05 Foam Verdeso 0.05 Low potency (group 6) Cream, solution Synalarb 0.01 Fluocinolone acetonide Shampoo Capex 0.01 c Derma-Smoothe/FS Body, Oil 0.01 Derma-Smoothe/FS Scalp Triamcinolone acetonide Cream, lotion Kenalogb, Aristocortb 0.025 2690.
Load more

Recommended publications
  • A New Robust Technique for Testing of Glucocorticosteroids in Dogs and Horses Terry E
    Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 2007 A new robust technique for testing of glucocorticosteroids in dogs and horses Terry E. Webster Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Veterinary Toxicology and Pharmacology Commons Recommended Citation Webster, Terry E., "A new robust technique for testing of glucocorticosteroids in dogs and horses" (2007). Retrospective Theses and Dissertations. 15029. https://lib.dr.iastate.edu/rtd/15029 This Thesis is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. A new robust technique for testing of glucocorticosteroids in dogs and horses by Terry E. Webster A thesis submitted to the graduate faculty in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Major: Toxicology Program o f Study Committee: Walter G. Hyde, Major Professor Steve Ensley Thomas Isenhart Iowa State University Ames, Iowa 2007 Copyright © Terry Edward Webster, 2007. All rights reserved UMI Number: 1446027 Copyright 2007 by Webster, Terry E. All rights reserved. UMI Microform 1446027 Copyright 2007 by ProQuest Information and Learning Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. ProQuest Information and Learning Company 300 North Zeeb Road P.O. Box 1346 Ann Arbor, MI 48106-1346 ii DEDICATION I want to dedicate this project to my wife, Jackie, and my children, Shauna, Luke and Jake for their patience and understanding without which this project would not have been possible.
    [Show full text]
  • Steroid Use in Prednisone Allergy Abby Shuck, Pharmd Candidate
    Steroid Use in Prednisone Allergy Abby Shuck, PharmD candidate 2015 University of Findlay If a patient has an allergy to prednisone and methylprednisolone, what (if any) other corticosteroid can the patient use to avoid an allergic reaction? Corticosteroids very rarely cause allergic reactions in patients that receive them. Since corticosteroids are typically used to treat severe allergic reactions and anaphylaxis, it seems unlikely that these drugs could actually induce an allergic reaction of their own. However, between 0.5-5% of people have reported any sort of reaction to a corticosteroid that they have received.1 Corticosteroids can cause anything from minor skin irritations to full blown anaphylactic shock. Worsening of allergic symptoms during corticosteroid treatment may not always mean that the patient has failed treatment, although it may appear to be so.2,3 There are essentially four classes of corticosteroids: Class A, hydrocortisone-type, Class B, triamcinolone acetonide type, Class C, betamethasone type, and Class D, hydrocortisone-17-butyrate and clobetasone-17-butyrate type. Major* corticosteroids in Class A include cortisone, hydrocortisone, methylprednisolone, prednisolone, and prednisone. Major* corticosteroids in Class B include budesonide, fluocinolone, and triamcinolone. Major* corticosteroids in Class C include beclomethasone and dexamethasone. Finally, major* corticosteroids in Class D include betamethasone, fluticasone, and mometasone.4,5 Class D was later subdivided into Class D1 and D2 depending on the presence or 5,6 absence of a C16 methyl substitution and/or halogenation on C9 of the steroid B-ring. It is often hard to determine what exactly a patient is allergic to if they experience a reaction to a corticosteroid.
    [Show full text]
  • St John's Institute of Dermatology
    St John’s Institute of Dermatology Topical steroids This leaflet explains more about topical steroids and how they are used to treat a variety of skin conditions. If you have any questions or concerns, please speak to a doctor or nurse caring for you. What are topical corticosteroids and how do they work? Topical corticosteroids are steroids that are applied onto the skin and are used to treat a variety of skin conditions. The type of steroid found in these medicines is similar to those produced naturally in the body and they work by reducing inflammation within the skin, making it less red and itchy. What are the different strengths of topical corticosteroids? Topical steroids come in a number of different strengths. It is therefore very important that you follow the advice of your doctor or specialist nurse and apply the correct strength of steroid to a given area of the body. The strengths of the most commonly prescribed topical steroids in the UK are listed in the table below. Table 1 - strengths of commonly prescribed topical steroids Strength Chemical name Common trade names Mild Hydrocortisone 0.5%, 1.0%, 2.5% Hydrocortisone Dioderm®, Efcortelan®, Mildison® Moderate Betamethasone valerate 0.025% Betnovate-RD® Clobetasone butyrate 0.05% Eumovate®, Clobavate® Fluocinolone acetonide 0.001% Synalar 1 in 4 dilution® Fluocortolone 0.25% Ultralanum Plain® Fludroxycortide 0.0125% Haelan® Tape Strong Betamethasone valerate 0.1% Betnovate® Diflucortolone valerate 0.1% Nerisone® Fluocinolone acetonide 0.025% Synalar® Fluticasone propionate 0.05% Cutivate® Hydrocortisone butyrate 0.1% Locoid® Mometasone furoate 0.1% Elocon® Very strong Clobetasol propionate 0.1% Dermovate®, Clarelux® Diflucortolone valerate 0.3% Nerisone Forte® 1 of 5 In adults, stronger steroids are generally used on the body and mild or moderate steroids are used on the face and skin folds (armpits, breast folds, groin and genitals).
    [Show full text]
  • New Zealand Data Sheet
    NEW ZEALAND DATA SHEET 1 NERISONE® NERISONE® Diflucortolone valerate 0.1 % fatty ointment NERISONE® Diflucortolone valerate 0.1 % cream 2 QUALITATIVE AND QUANTITATIVE COMPOSITION NERISONE® Cream: 1 g white cream contains 1 mg (0.1 %) diflucortolone valerate. The cream is an oil-in-water emulsion containing approximately 70% water. NERISONE® Fatty Ointment: 1 g white single-phase fatty ointment contains 1 mg (0.1 %) diflucortolone valerate. NERISONE® Fatty Ointment contains methyl parahydroxybenzoate and propyl parahydroxybenzoate. For the full list of excipients, see section 6.1. 3 PHARMACEUTICAL FORM Topical cream Topical fatty ointment 4 CLINICAL PARTICULARS 4.1 Therapeutic indications All skin diseases which respond to topical corticoid therapy (eg): contact dermatitis, contact eczema, occupational eczema vulgar, nummular, degenerative and seborrhoeic eczema, dyshidrotic eczema, eczema in varicose syndrome (but not directly onto lower limb ulcers), anal eczema, eczema in children, neurodermatitis (endogenous eczema, atopic dermatitis), psoriasis, lichen ruber planus et verrucosus, lupus erythematosus discoides, first degree burns, sunburn, insect bites. 4.2 Dose and method of administration At the beginning of treatment, the NERISONE® preparation best suited to the skin condition is applied thinly two or perhaps three times per day. Once the clinical picture has improved, one application per day usually suffices. NERISONE® is available as a cream and a fatty ointment. Which form should be used in the individual case will depend on the appearance of the skin: NERISONE® CREAM in weeping skin conditions and NERISONE® FATTY OINTMENT in very dry skin conditions. NERISONE® CREAM has a high water and low fat content. In weeping skin diseases it allows secretions to drain away, thus providing for rapid subsidence and drying up of the skin.
    [Show full text]
  • PRODUCT MONOGRAPH NERISALIC® (0.1% Diflucortolone Valerate and 3% Salicylic Acid) OILY CREAM THERAPEUTIC CLASSIFICATION TOPICAL
    PRODUCT MONOGRAPH NERISALIC® (0.1% diflucortolone valerate and 3% salicylic acid) OILY CREAM THERAPEUTIC CLASSIFICATION TOPICAL CORTICOSTEROID-KERATOLYTIC GlaxoSmithKline Inc. Date of Preparation: 7333 Mississauga Road May 11, 2010 Mississauga, Ontario L5N 6L4 www.stiefel.ca Control Number: 138393 ©2010 GlaxoSmithKline Inc., All Rights Reserved ®NERISALIC used under license by GlaxoSmithKline Inc. 2010-04-23/131-pristine-english-Nerisalic.doc Page 1 of 14 PRODUCT MONOGRAPH NERISALIC® (0.1% diflucortolone valerate and 3% salicylic acid) OILY CREAM THERAPEUTIC CLASSIFICATION TOPICAL CORTICOSTEROID-KERATOLYTIC ACTIONS AND CLINICAL PHARMACOLOGY NERISALIC® (0.1% diflucortolone valerate and 3% salicylic acid) Oily Cream combines the anti-inflammatory, anti-pruritic and vasoconstrictive activity of diflucortolone valerate and the keratolytic effects of salicylic acid. Both diflucortolone valerate and its split ester are topically active. INDICATIONS AND CLINICAL USE NERISALIC® (0.1% diflucortolone valerate and 3% salicylic acid) Oily Cream is indicated in the topical treatment of chronic eczema, psoriasis vulgaris, neuro-dermatitis and scaly crusty dermatoses which respond to corticosteroid therapy. NERISALIC® Oily Cream is not suitable for the treatment of perioral dermatitis and rosacea. CONTRAINDICATIONS NERISALIC® (0.1% diflucortolone valerate and 3% salicylic acid) Oily Cream is contraindicated in patients who have shown hypersensitivity, allergy or intolerance to diflucortolone valerate or other corticosteroids or salicylic acid or to any excipients in the preparation. NERISALIC® Oily Cream should not be applied to skin areas with fissures, erosions, scratches or excoriations. 2010-04-23/131-pristine-english-Nerisalic.doc Page 2 of 14 Topical steroids are contraindicated in untreated bacterial and/or fungal skin infections. Topical steroids should not be applied in cases of tuberculosis of the skin, or syphilitic skin infections, chicken pox, eruptions following vaccinations and viral diseases of the skin in general.
    [Show full text]
  • Basic Skin Care and Topical Therapies for Atopic Dermatitis
    REVIEWS Basic Skin Care and Topical Therapies for Atopic Dermatitis: Essential Approaches and Beyond Sala-Cunill A1*, Lazaro M2*, Herráez L3, Quiñones MD4, Moro-Moro M5, Sanchez I6, On behalf of the Skin Allergy Committee of Spanish Society of Allergy and Clinical Immunology (SEAIC) 1Allergy Section, Internal Medicine Department, Hospital Universitario Vall d'Hebron, Barcelona, Spain 2Allergy Department, Hospital Universitario de Salamanca, Alergoasma, Salamanca, Spain 3Allergy Department, Hospital Universitario 12 de Octubre, Madrid, Spain 4Allergy Section, Hospital Monte Naranco, Oviedo, Spain 5Allergy Department, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain 6Clínica Dermatología y Alergia, Badajoz, Spain *Both authors contributed equally to the manuscript J Investig Allergol Clin Immunol 2018; Vol. 28(6): 379-391 doi: 10.18176/jiaci.0293 Abstract Atopic dermatitis (AD) is a recurrent and chronic skin disease characterized by dysfunction of the epithelial barrier, skin inflammation, and immune dysregulation, with changes in the skin microbiota and colonization by Staphylococcus aureus being common. For this reason, the therapeutic approach to AD is complex and should be directed at restoring skin barrier function, reducing dehydration, maintaining acidic pH, and avoiding superinfection and exposure to possible allergens. There is no curative treatment for AD. However, a series of measures are recommended to alleviate the disease and enable patients to improve their quality of life. These include adequate skin hydration and restoration of the skin barrier with the use of emollients, antibacterial measures, specific approaches to reduce pruritus and scratching, wet wrap applications, avoidance of typical AD triggers, and topical anti-inflammatory drugs. Anti-inflammatory treatment is generally recommended during acute flares or, more recently, for preventive management.
    [Show full text]
  • Dexamethasone/Fluclorolone Acetonide 1529 UK: Dexa-Rhinaspray Duo†; Maxitrol; Otomize; Sofradex; Tobradex; Described on P.1492
    Dexamethasone/Fluclorolone Acetonide 1529 UK: Dexa-Rhinaspray Duo†; Maxitrol; Otomize; Sofradex; Tobradex; described on p.1492. For recommendations concerning the cor- Malaysia: Isoradin; Travocort; Mex.: Bi-Nerisona; Scheriderm; NZ: USA: Ak-Neo-Dex; Ak-Trol†; Ciprodex; Dexacidin†; Dexacine†; Dexas- rect use of corticosteroids on the skin, and a rough guide to the Nerisone C; Philipp.: Nerisona Combi; Travocort; Pol.: Travocort; Port.: porin; Maxitrol; Neo-Dexameth†; NeoDecadron†; Neodexasone; Ne- Nerisona C; Travocort; Rus.: Travocort (Травокорт); S.Afr.: Travocort; opolydex; Ocu-Trol; Poly-Dex; Tobradex; Venez.: Baycuten N; Cipromet†; clinical potencies of topical corticosteroids, see p.1497. Singapore: Nerisone C†; Travocort; Spain: Claral Plus; Switz.: Travocort; Cyprodex; Decadron†; Decaven; Deicol†; Dexaneol†; Dexapostafen; Gen- Preparations Thai.: Travocort; Turk.: Impetex; Nerisona C; Travazol; Travocort; Venez.: tidexa; Kanasone†; Maxicort; Maxitrol; Otocort; Poentobral Plus; Poli-Oti- Binerisona. co; Quinocort; Tobracort; Tobradex; Tobragan D; Todex; Trazidex. USP 31: Diflorasone Diacetate Cream; Diflorasone Diacetate Ointment. Proprietary Preparations (details are given in Part 3) Ger.: Florone; Ital.: Dermaflor†; Mex.: Diasorane; Spain: Murode; USA: ApexiCon; Florone; Maxiflor; Psorcon. Difluprednate (USAN, rINN) ⊗ Dichlorisone Acetate (rINNM) ⊗ Multi-ingredient: Arg.: Filoderma; Filoderma Plus; Griseocrem; Novo CM-9155; Difluprednato; Difluprednatum; W-6309. 6α,9α-Dif- Acetato de diclorisona; Dichlorisone, Acétate de; Dichlorisoni Bacticort Complex†; Novo Bacticort†. luoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-ac- Acetas; Diclorisone Acetate. 9α,11β-Dichloro-17α,21-dihydrox- etate 17-butyrate. ypregna-1,4-diene-3,20-dione 21-acetate. Дифлупреднат Дихлоризона Ацетат Diflucortolone (BAN, USAN, rINN) ⊗ C H F O = 508.6. C H Cl O = 455.4. Diflucortolona; Diflucortolonum; Diflukortolon; Diflukortoloni. 27 34 2 7 23 28 2 5 CAS — 23674-86-4.
    [Show full text]
  • Improved Penetrating Topical Pharmaceutical Compositions Containing Corticosteroids
    Europaisches Patentamt ® European Patent Office © Publication number: 0 129 283 Office europeen des brevets A2 © EUROPEAN PATENT APPLICATION © Application number: 84200821.1 ©Int CI.3: A 61 K 31/57 A 61 K 47/00, A 61 K 9/06 © Date of filing: 12.06.84 © Priority: 21.06.83 US 506274 © Applicant: THE PROCTER & GAMBLE COMPANY 01.02.84 US 576065 301 East Sixth Street Cincinnati Ohio 45201 (US) © Date of publication of application: © Inventor: Cooper, Eugene Rex 27.12.84 Bulletin 84/52 2425 Ambassador Drive Cincinnati, OH 45231 (US) © Designated Contracting States: BE CH DE FR GB IT Li NL SE © Inventor: Loomans, Maurice Edward 5231 Jessup Road Cincinnati, OH 45239IUS) © Inventor: Fawzi, Mahdi Bakir 11 Timberline Drive Flanders New Jersey 07836(US) © Representative: Suslic, Lydia et al, Procter & Gamble European Technical Center Temselaan 100 B-1820 Strombeek-Bever(BE) © Improved penetrating topical pharmaceutical compositions containing corticosteroids. Topical pharmaceutical compositions containing a cor- ticosteroid component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C3-C4 diol and a "cell-envelope disordering compound". The vehicle provides marked transepidermal and percutaneous delivery of corticosteroids. A method of treating certain rheumatic and inflammatory conditions, systemically or loc- ally, is also disclosed. TECHNICAL FIELD The present invention relates to topical compositions effective in delivering high levels of certain pharmaceutically-active cor- ticosteroid agents through the integument. Because of the ease of access, dynamics of application, large surface area, vast exposure to the circulatory and lymphatic networks, and non-invasive nature of the treatment, the delivery of pharmaceutically-active agents through the skin has long been a promising concept.
    [Show full text]
  • Guidelines for the Management of Atopic Dermatitis in Singapore
    Management of Atopic Dermatitis—Yong Kwang Tay et al 439 Original Article Guidelines for the Management of Atopic Dermatitis in Singapore 1 2 Yong Kwang Tay, MMed (Int Med), FRCP (London), FAMS (Dermatology) (Chairman), Yuin Chew Chan, MBBS, MRCP (UK), FAMS (Dermatology), 3 4 5 Nisha Suyien Chandran, MRCP (UK), MMed (Int Med), FAMS (Dermatology), Madeline SL Ho, MBChB (Edin), MRCP (UK), MSc (London), Mark JA Koh, MBBS, 4 4 MRCPCH (UK), FAMS (Dermatology), Yen Loo Lim, MBBS, FRCP (Edin), FAMS (Dermatology), Mark BY Tang, MMed (Int Med), FRCP (Edin), FAMS (Dermatology), 6,7 Thamotharampillai Thirumoorthy, FRCP (London), FRCP (Glasg), FAMS (Dermatology) Abstract Introduction: Atopic dermatitis is a common, chronic pruritic condition affecting both children and adults, which has a negative impact on the quality of life. These guidelines were developed by an expert workgroup appointed by the Dermatological Society of Singapore, to provide doctors with information to assist in the management of their patients with atopic dermatitis. The workgroup members are experienced dermatologists with interest and expertise in eczemas. Materials and Methods: Workgroup members arrived at a consensus on the topics to be included. Relevant studies from the literature were assessed for best evidence, supplemented by the collective experience of the workgroup. Results: For mild atopic dermatitis, emollients, mild potency topical steroids and topical calcineurin inhibitors are recommended. For moderate-to-severe atopic dermatitis, the use of emollients, moderate- to-potent topical steroids, topical calcineurin inhibitors, wet dressings, antimicrobials for secondary skin infection, phototherapy, and systemic therapy (e.g. prednisolone, cyclosporine, azathioprine or methotrexate) may be warranted. Patients with moderate-to-severe atopic dermatitis should be managed in conjunction with a dermatologist.
    [Show full text]
  • Methylprednisolone Aceponate 0.1% Ointment/Cream [Advantan®] PRODUCT REVIEW 0.1% Ointment/Cream [Advantan®]
    Methylprednisolone aceponate 0.1% ointment/cream A RESEARCH REVIEW™ PRODUCT REVIEW [Advantan®] Making Education Easy 2021 About the expert This review discusses the evidence in support of the use of methylprednisolone aceponate (MPA) 0.1% ointment/cream [Advantan®], a fourth-generation, non-halogenated topical corticosteroid approved for use in New Zealand for the management of eczema. MPA exhibits a fast and effective itch relief profile in infants and children with atopic eczema. MPA has the advantage of once-daily dosing, providing benefits in terms of patient compliance, and has an optimised efficacy/safety profile with minimal local or systemic adverse effects. This agent is suitable for use in adults and children Dr Jennifer Pilgrim and also for short-term use on the face. The choice of 2 topical MPA formulations allows tailored MB ChB (Otago), FRACP treatment for a variety of eczema types and locations. MPA 0.1% ointment/cream is fully funded. This review is sponsored by an educational grant from Leo Pharma Limited. A graduate of Otago University, Dr Jennifer Pilgrim undertook post-graduate training at Wadsworth VA-UCLA, California and St John’s Hospital, London. Atopic eczema She practices as a specialist dermatologist at Atopic eczema (also known as atopic dermatitis) is a chronically relapsing, intensely pruritic inflammatory Bowen Hospital, Wellington and at Kew Hospital skin disease that favours flexural skin and is characterised by periods of acute worsening (“flares”) in Invercargill. Jennifer has extensive experience alternating with periods of relative quiescence following treatment.1,2 The condition typically develops in in a wide range of dermatological areas including childhood, with approximately 80% of cases developing before the age of 5 years.3 In the acute phase of paediatric and adolescent dermatology, minor the disease, erythema, vesicles, papules, crusts and weeping may be present, while in the chronic phase, surgery, tattoo removal, vulval disorders and some 4 cosmetic procedures.
    [Show full text]
  • Exogenous Steroids Treatment in Adults. Adrenal Insufficiency And
    Exogenous steroids treatment in adults. Adrenal insufficiency and adrenal crisis-who is at risk and how should they be managed safely. David Erskine- Specialist Pharmacy Services (SPS) Helen Simpson on behalf of Society for Endocrinology Steroid Emergency Card working group Endorsed by the Society for Endocrinology and the British Association of Dermatologists Introduction Recently published guidance on the prevention and emergency management of adult patients with adrenal insufficiency (AI) (Simpson 2020) outlined the general issues relating to adrenal crisis. This was subsequently supported by an NHS England and NHS Improvement national patient safety alert (NatPSA) promoting the use of a new Steroid Emergency Card to support the early recognition and treatment of adrenal crisis in adults (NHSE/I 2020). This highlighted four deaths, four critical care admissions, and around 320 other incidents related to this issue in a two year period. Given variability of reporting, this is likely to be an underestimate of the incidents surrounding AI and adrenal crisis. The NatPSA specified a number of actions that organisations need to implement to operationalise the introduction of the new Steroid Emergency Card. However it has become clear that many groups need support on how to identify patients at risk of AI from exogenous steroids, both for clinical safety around advice for patients undergoing surgery or invasive procedures, and to clarify who needs additional steroid cover for procedures, who needs to be given sick day rules advice and who requires a Steroid Emergency Card. The purpose of this document is to offer guidance based on expert opinion (Society for Endocrinology (SfE) Steroid Emergency Card working group and Specialist Pharmacy Services) for challenging clinical issues around AI where these is no hard evidence in the medical literature; The 4 areas of recommendation are: 1.
    [Show full text]
  • Topical Corticosteroids Used at Leeds Teaching Hospitals Information
    Medicines Management & Pharmacy Services (MMPS) Topical Corticosteroids used at Leeds Teaching Hospitals Information Mild and moderate potency (potent and very potent on following page) Mild Corticosteroids Brand Name Active Ingredients Formulation Dioderm ® Hydrocortisone 0.1% Cream Hydrocortisone Hydrocortisone 0.5% Cream and Ointment Hydrocortisone Hydrocortisone 1% Cream and Ointment Hydrocortisone Hydrocortisone 2.5% Cream Mild Corticosteroids with Antimicrobials Brand Name Active Ingredients Formulation Canestan HC ® Hydrocortisone 1%, Clotrimazole 1% Cream Daktacort ® Hydrocortisone 1%, Miconazole nitrate 2% Cream and Ointment Fucidin H ® Hydrocortisone 1%, Fusidic Acid 2% Cream Timodine ® Hydrocortisone 0.5%,Nystatin 100,000units/Chlorhexidine 1% Cream Other Mild Corticosteroid Combination Preparations Brand Name Active Ingredients Formulation Eurax-HC ® Hydrocortisone 0.25%, Crotamiton 10% Cream Moderate Corticosteroids Brand Name Active Ingredients Formulation Betnovate RD ® Betamethasone 0.025% Cream and Ointment Eumovate ® Clobetasone Butyrate 0.05% Cream and Ointment Cream, Ointment, Haelan ® Fludroxycortide 0.0125% Tape Moderate Corticosteroids with Antimicrobials Brand Name Active Ingredients Formulation Trimovate ® Clobetasone Butyrate 0.05%, Oxytetracycline 3% Cream Nystatin 100 000 units/g Other Moderate Corticosteroid Combination Preparations None stocked at LTHT References and Provenance Date Produced: 14/12/2011 Valid until: 14/12/2013 Review Date: Author: Nora Sadiq, pharmacist Quality Assurance Check by: Steve Ashmore,
    [Show full text]