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University of Minnesota Health MINCEP® Care OptiMed® Patient Guide to

Generic Name Trade Name Common Use Common and/or Serious Side Effects Name based on the Name used by the Types of the is most These side effects may require medication dosage chemical composition company to market commonly used to control adjustment or discontinuation of the medication of the medication the medication

BRIVIACT® partial-onset seizures sleepiness, , fatigue, loss of coordination, irritability, Tegretol® simple and complex partial and generalized drowsiness, dizziness, blurred or double vision, carbamazepine ER Tegretol® XR motor (tonic-clonic) seizures loss of coordination, hyponatremia, rash, leukopenia, birth defects carbamazepine Carbatrol® simple and complex partial and generalized drowsiness, dizziness, blurred or double vision, ER Multiphase motor (tonic-clonic) seizures loss of coordination, hyponatremia, rash, leukopenia, birth defects Onfi® seizures associated with Lennox-Gastaut sedation, drowsiness, fatigue, constipation, drooling, aggression, fever, rash (rarely severe) Klonopin® atonic, myoclonic drowsiness, dizziness, irritability, behavior changes, loss of coordination, slurred speech, mood changes Diastat® for interruption of prolonged seizures , dizziness, or seizure clusters headache, incoordination diazepam Diazepam® for interruption of prolonged seizures somnolence, dizziness, concentrate lntensol or seizure clusters headache, incoordination 5mg/ml eslicarbazepine Aptiom® partial-onset seizures dizziness, drowsiness, unsteadiness, double vision, nausea, headache, rash, hyponatremia, swelling of lips and throat Zarontin® absence drowsiness, nausea/vomiting, , sleep disturbance, hyperactivity, hiccups ezogabine Potiga simple and complex partial, generalized dizziness, drowsiness, fatigue, poor coordination, motor (tonic-clonic) seizures blurred or double vision, , , urinary retention, skin discolorations, retina changes Felbatol® refractory epilepsy only: complex partial weight loss, stomach upset, difficulty sleeping, generalized (tonic-clonic) seizures; seizures headache, aplastic anemia (blood disorder) (rare), associated with Lennox-Gastaut Syndrome failure (rare) Neurontin® simple and complex partial and generalized drowsiness, dizziness, loss of coordination or motor (tonic-clonic) seizures blurred vision, weight gain Vimpat® partial seizures dizziness, unsteadiness, double vision, blurred vision, nausea, vomiting, fatigue, headache, tremor Lamictal simple and complex partial and secondarily dizziness, headache, double vision, nausea, Lamictal ODT generalized tonic-clonic seizures; seizures sleepiness, loss of coordination, rash (rarely severe) Lamictal XR® associated with Lennox-Gaustaut Syndrome Keppra® simple and complex partial and secondarily drowsiness, dizziness, fatigue, weakness and Keppra XR® generalized tonic-clonic seizures mood changes, lack of energy, agitation or hostility Ativan® for interruption of prolonged seizures or drowsiness, dizziness, irritability, behavior seizure clusters changes, loss of coordination lorazepam Lorazepam for interruption of prolonged seizures drowsiness, dizziness, irritability, behavior concentrate lntensol™ or seizure clusters changes, loss of coordination 2mg/ml Trileptal® simple and complex partial and generalized dizziness, drowsiness, fatigue, abnormal gait, motor (tonic-clonic) seizures mood changes, unsteadiness, hyponatremia, rash Generic Name Trade Name Common Use Common and/or Serious Side Effects Name based on the Name used by the Types of seizures the medication is most These side effects may require medication dosage chemical composition company to market commonly used to control adjustment or discontinuation of the medication of the medication the medication

Fycompa® simple and complex partial and secondarily dizziness, somnolence, fatigue, irritability, nausea, generalized tonic-clonic seizures, primary balance problems generalized tonic-clonic seizures no commonly simple and complex partial and primary drowsiness, irritability, dizziness, behavior used trade name and secondarily generalized tonic-clonic changes, loss of coordination, slurred speech, seizures mood changes, rash, liver problems Dilantin® simple partial, complex partial and increased hair growth, gum tissue overgrowth, Phenytek® generalized motor (tonic-clonic) seizures loss of coordination, blurred or double vision, dizziness, confusion, slurred speech, rash, liver problems, swollen lymph nodes, osteoporosis Lyrica® simple and complex partial and secondarily Somnolence, dry mouth, blurred vision, peripheral generalized tonic-clonic seizures edema, weight gain and abnormal thinking Mysoline® simple and complex partial and secondarily drowsiness, irritability, dizziness, behavior generalized tonic-clonic; generalized motor changes, loss of coordination, slurred speech, (tonic-clonic) seizures mood changes, rash, liver problems Banzel® seizures associated with Lennox-Gastaut headache, dizziness, fatigue, nausea, tiredness, double vision, vomiting tiagabine Gabitril® simple and complex partial seizures nausea/vomiting, dizziness, sleepiness, difficulty with concentration, speech or language problems, nervousness, mood problems, rash Topamax® simple and complex partial epilepsy, speech or language problems, fatigue, with or without generalized tonic-clonic nervousness, difficulty with concentration/ seizures, primary generalized tonic-clonic attention, , mood problems, decreased seizures, seizures associated with appetite, weight loss, stones, glaucoma Lennox-Gastaut Syndrome valproic acid Depakene® primary generalized tonic-clonic, absence, nausea/vomiting, indigestion, dizziness, hair loss, divalproex sodium DR Depakote® myoclonic, tonic, atonic, complex partial tremor, drowsiness, weight gain, liver failure (rare) divalproex sodium ER Depakote® ER and secondarily generalized tonic-clonic mostly in children less than 2 years, pancreatitis, birth defects Sabril® refractory complex partial seizures, headache, fatigue, insomnia, tiredness, dizziness, infantile spasms poor coordination, weight gain, visual field defect, mood changes Zonegran® partial and generalized motor (tonic-clonic) drowsiness, weight loss, double vision, dizziness, seizures nausea, overheating, irritability, mood changes, kidney stones, rash

Outpatient services provided at: Side effects displayed in bold need immediate medical attention. University of Minnesota Health MINCEP Epilepsy Care 5775 Wayzata Blvd., Suite 255 More serious or even life threatening side effects St. Louis Park, MN 55416 may develop from these medications, some of which include allergic reactions (such as rash), University of Minnesota Health Neurology Clinic liver changes and/or blood changes. Use of these Clinics and Surgery Center medications during pregnancy may be harmful to 909 Fulton St. SE, Minneapolis, MN 55455 the developing fetus. Patients should consult with University of Minnesota Health Neurology their physicians before becoming pregnant. Women Maple Grove Clinics of childbearing age should take a multi-vitamin and ​14500 99th Ave. N, Maple Grove, MN 55369 folic acid daily. This chart does not offer solutions to individual patient care issues. Indications for the AEDs listed above are based on MINCEP’s Call to schedule an appointment: 952-525-4500 or 800-359-4477 clinical experience and use. The prescription of mhealth.org/epilepsy antiepileptic drugs is complex and varies depending on individual facts and circumstances. Patients must ©2017 University of Minnesota Physicians and use the medication(s) as prescribed and inform their University of Minnesota Medical Center. Mktg 338263. SW 545405. 10.17 physicians of side effects.