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Mitochondrial Ubiquitin Ligase MITOL Blocks S-Nitrosylated MAP1B-Light Chain 1-Mediated Mitochondrial Dysfunction and Neuronal Cell Death
Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death Ryo Yonashiro, Yuya Kimijima, Takuya Shimura, Kohei Kawaguchi, Toshifumi Fukuda, Ryoko Inatome, and Shigeru Yanagi1 Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan Edited by Ted M. Dawson, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, and accepted by the Editorial Board January 3, 2012 (received for review September 14, 2011) Nitric oxide (NO) is implicated in neuronal cell survival. However, recently been shown to be S-nitrosylated on cysteine 257 and excessive NO production mediates neuronal cell death, in part via translocated to microtubules via a conformational change of LC1 mitochondrial dysfunction. Here, we report that the mitochondrial (12). Additionally, LC1 has been implicated in human neuro- ubiquitin ligase, MITOL, protects neuronal cells from mitochondrial logical disorders, such as giant axonal neuropathy (GAN), frag- damage caused by accumulation of S-nitrosylated microtubule- ile-X syndrome, spinocerebellar ataxia type 1, and Parkinson associated protein 1B-light chain 1 (LC1). S-nitrosylation of LC1 in- disease (10, 13, 14). Therefore, the control of S-nitrosylated LC1 duces a conformational change that serves both to activate LC1 and levels is critical for neuronal cell survival. fi to promote its ubiquination by MITOL, indicating that microtubule We previously identi ed a mitochondrial ubiquitin ligase, MITOL (also known as March5), which is involved in mito- stabilization by LC1 is regulated through its interaction with MITOL. – Excessive NO production can inhibit MITOL, and MITOL inhibition chondrial dynamics and mitochondrial quality control (15 19). -
8 CURLING ICE in an ARENA Written by Leif Öhman, Sweden & John Minnaar, Scotland
1 8 CURLING ICE IN AN ARENA Written by Leif Öhman, Sweden & John Minnaar, Scotland To overcome the problems of dealing with different situations for different purposes, there will be some duplication in the section, which is presented as two different approaches to a similar problem. FROM ICE TO CURLING ICE The words of this heading are carefully chosen, The solutions because the two items are very different. Ice is simply the result of water being frozen by 1. As every experienced curling manager lowering its temperature to below 0ºC, whereas knows, someone has to provide the driving curling ice is a manufactured product of specific force and maintain the momentum, but one definition that has been made from ice, or by person cannot hope to do it all himself. freezing water in a very specific way. The skating-ice technician is the person with It is the purpose of this half of the section to bring much to do and not enough time and now, together the relevant essential pieces of with curling on the scene, someone is giving information scattered throughout the manual, to him even more to do. The skating-ice enable technicians to convert ice to curling ice in technician is also a very important person, an efficient and cost-effective way on a regular respect his position. basis. In the next half of this section, Curling Ice To solve this, form a club of all known In An Arena, the same subject is addressed, but curlers, have a meeting and select a there it is aimed at providing excellent ice for a committee. -
2007 Lake Monitoring Report Mecklenburg County Water Quality Program SWIM Phase I Part 2-CO
2007 Lake Monitoring Report Mecklenburg County Water Quality Program SWIM Phase I Part 2-CO Prepared by: David Buetow Final Report for FY2007-2008 PURPOSE AND BACKGROUND The Mecklenburg County Water Quality Program (MCWQP) has an ongoing program to monitor the water quality in the three Catawba Lakes bordering the county: Lake Norman, Mountain Island Lake and Lake Wylie. Samples are also routinely collected at the two water bodies in the northern end of Mecklenburg County cut off from Lake Norman proper by I-77: Lake Cornelius and Lake Davidson. Data collected from all lake sites are used to screen for environmental problems using MCWQP Action and Watch levels for various pollutants and also to rate the overall water quality at sampling locations in the lakes using a water quality index. Additional objectives are to describe seasonal trends and address spatial variability in the data. This report presents the lake monitoring data for the calendar year 2007 ACTIVITIES AND METHODS Regular monthly lake sampling was conducted at seven locations in Lake Norman and one location each on Lake Cornelius and Lake Davidson (Appendix A), ten locations in Mountain Island Lake (Appendix B) and eight sampling locations in Lake Wylie (Appendix C). In May 2007, the sampling program was changed in Lake Wylie to add several new cove monitoring sites. This resulted in an increase in regular sampling sites in Lake Wylie from eight to thirteen (Appendix D). Lakes Norman, Wylie and Mountain Island were sampled monthly from May through September and every other month during the rest of the year, i.e. -
Boccia Bean Bags, Koosh Balls, Paper & Tape Balls, Fluff Balls
Using the Activity Cards Sports Ability is an inclusive activities program There may be some differences concerning rules, equipment that adopts a social / environmental approach and technique. However, teachers, coaches and sports leaders to inclusion. This approach concentrates on the working in a physical activity and sport setting can treat young people with a disability in a similar way to any of their other ways in which teachers, coaches and sports athletes or students. The different stages of learning and the leaders can adjust, adapt and modify the way in basic techniques of skill teaching apply equally for young people which an activity is delivered rather than focus with disabilities. A teacher, coach or sports leader can ensure on individual disabilities. their approach is inclusive by applying the TREE principle. TREE stands for: Teaching / coaching style Observing, questioning, applying and reviewing. Example: a flexible approach to communication to ensure that information is shared by all. Rules In competitive and small-sided activities. Example: allowing two bounces of the ball in a tennis activity, or more lives for some players in a tag game. Equipment Vary to provide more options. Example: using a brighter coloured ball or a sound ball to assist players with tracking. Environment Space, surface, weather conditions. Example: enabling players with different abilities to play in different sized spaces. TREE can be used as a practical tool and a mental map to help teachers, coaches and Try the suggestions provided on the back of sports leaders to adapt and modify game each card when modifying the games and situations to be more inclusive of people activities or use the TREE model to develop with wide range of abilities. -
IV. Teaching Game for Understanding International Conference, Vancouver, CA May 14- 17, 2008
IV. Teaching Game for Understanding International Conference, Vancouver, CA May 14- 17, 2008, ABSTRACT: Proposal title: Physical Engagement, Social Responsibility, Enhanced SelfConfidence with TCHOUKBALL Dr. Hermann Brandt, a sport physician, invented Tchoukball in 1970 in Switzerland. In his scientific study, Dr. Brandt made a critical analysis of today’s sports, such as soccer, basketball, and ice hockey, and compared them with the unique and innovative specifications of the game of Tchoukball. Dr. Brandt demonstrated that with Tchoukball it is possible to have a team sport where there is no blocking defense or interference, which is still fast-paced and vigorous, as well as physically and strategically challenging. The main idea behind the invention of the game of Tchoukball was to give people with different levels of athletic skills an opportunity to be successful in a team sport. The concept of TEAM was very important for Dr. Brandt because of its social aspects, such as recognition by peers, self- confidence, inclusion in a social group (the team), cooperation, tolerance, and improvement through play. In this session, attendees will first learn the rules and then play the game of Tchoukball. They will then discover how to use this game for the physical, social and emotional development of their students. Participants will be introduced to the unique concept of play through Tchoukball and experience the game hands-on. With appropriate exercises, attendees will discover how learning and playing Tchoukball can lead to addressing the broad educational standards associated with physical health concepts, such as problem solving, social responsibility and behavior, care and concern for peers, enhanced confidence, and enjoyment in playing the game of Tchoukball as a lifelong physical activity. -
Throwing Distance and Competitive Performance of Boccia Players
J. Phys. Ther. Sci. 32: 574–577, 2020 The Journal of Physical Therapy Science Original Article Throwing distance and competitive performance of Boccia players Masataka Kataoka, PhD1)*, Kuniharu Okuda, PhD1), Akira Iwata, PhD1), Shuji Imura, MS1), Kosuke Yahagi, MS1), Yohei Matsuo2) 1) Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University: 3-7-30 Habikino, Habikino-city, Osaka 583-8555, Japan 2) Fukushima Rehabilitation Center for Children, Japan Abstract. [Purpose] This study aimed to clarify the relationship between throwing distance and competitive performance in Boccia players in order to establish a training program based on this evidence. [Participants and Methods] In total, 40 athletes, who competed in the Japan Boccia Championships and are certified players of the Japan Boccia Association, participated in the study. Participants threw the Boccia ball as far as possible, and throw- ing distances were compared between certified players (Group I, n=8), those who participated in the final round (Group II, n=9), and those who lost in the preliminary round (Group III, n=23). [Results] The maximum throwing distances were 16.38 ± 5.17 m (Group I), 10.67 ± 2.66 m (Group II), and 8.34 ± 2.73 m (Group III). Group I threw the ball significantly farther than Groups II and III. [Conclusion] Boccia is a target sport and throwing farther distances requires more effort. In addition, being able to throw at a longer distance means that Boccia players can throw a stronger ball and use this for various tactics. The results of this study suggest that long-distance throwing training would be effective in improving the competitive performance of Boccia players. -
Tokyo 2020 Paralympic Games
TOKYO 2020 PARALYMPIC GAMES QUALIFICATION REGULATIONS REVISED EDITION, APRIL 2021 INTERNATIONAL PARALYMPIC COMMITTEE 2 CONTENTS 1. Introduction 2. Tokyo 2020 Paralympic Games Programme Overview 3. General IPC Regulations on Eligibility 4. IPC Redistribution Policy of Vacant Qualification Slots 5. Universality Wild Cards 6. Key Dates 7. Archery 8. Athletics 9. Badminton 10. Boccia 11. Canoe 12. Cycling (Track and Road) 13. Equestrian 14. Football 5-a-side 15. Goalball 16. Judo 17. Powerlifting 18. Rowing 19. Shooting 20. Swimming 21. Table Tennis 22. Taekwondo 23. Triathlon 24. Volleyball (Sitting) 25. Wheelchair Basketball 26. Wheelchair Fencing 27. Wheelchair Rugby 28. Wheelchair Tennis 29. Glossary 30. Register of Updates INTERNATIONAL PARALYMPIC COMMITTEE 3 INTRODUCTION These Qualification Regulations (Regulations) describe in detail how athletes and teams can qualify for the Tokyo 2020 Paralympic Games in each of the twenty- two (22) sports on the Tokyo 2020 Paralympic Games Programme (Games Programme). It provides to the National Paralympic Committees (NPCs), to National Federations (NFs), to sports administrators, coaches and to the athletes themselves the conditions that allow participation in the signature event of the Paralympic Movement. These Regulations present: • an overview of the Games Programme; • the general IPC regulations on eligibility; • the specific qualification criteria for each sport (in alphabetical order); and • a glossary of the terminology used throughout the Regulations. STRUCTURE OF SPORT-SPECIFIC QUALIFICATION -
Introduction to Class S Law
Introduction to Class S Law 1 This schedule is the result of a rigorous and detailed analysis of the the vocabulary of law, using the techniques of facet analysis. As such, it represents a radical revision and expansion of Class S in the first edition of the Bibliographic Classification (BC1)1. The general reasons for making the revision so radical a one are given in the Introduction and Auxiliary schedules2. The particular changes in this class are considered in Section 15 below. 2 The Outline on page 1 (after the preliminary pages) is designed to give a clear view of the basic structure. If it is remembered that the schedule is an inverted one (see Section 8) the outline will be seen to show not only the general sequence of facets (categories) and their classes but also the basic operational rule in applying the classification. This is the rule that compound classes (those reflecting the intersection of two or more simpler classes) are located under the class appearing later (lower down) in the schedule. For example, Contract law is SBE; English law is SN; so the compound class English law of contract goes under English law (at SNE) and not under Contract. Similarly, Evidence is S8T; Criminal law is SBW; so the compound class Evidence in criminal law goes under Criminal law (at SBW 8T) and not under Evidence. 3 Scope of Class S and its place in BC2 3.1 The law considered in Class S may be defined briefly as the enforceable body of rules that governs any society. -
In an Effort to Standardize Ringette Line Markings Across the Country, the CRFC Has Worked in Consultation with Ringette Canada
In an effort to standardize ringette line markings across the country, the CRFC has worked in consultation with Ringette Canada on how best to layout a ringette ice sheet. The CRFC supports the revised layout and encourages facility managers to consider the benefits of conforming to these layout guidelines whenever possible. New construction and/or retrofits to a facility should give consideration to these measurements, however, other ice sport marking requirements should be overlayed prior to making any changes so that all ice sports are given the same consideration. The following drawings are offered as a support tool for ice technicians to your planning and annual ice painting activities. As ice markings may change at any time, be reminded of the importance for you to annually recheck all local and regional ice sport marking requirements prior to undertaking the ice painting task! VERSION 2013-7 CRFC - RINGETTE CANADA LINE MARKINGS Ice rinks that offer the sport of Ringette will be required to install additional painted/fabric markings. Ringette utilizes most of the standard Hockey Canada (HC) ice hockey markings with additional free pass dots in each of the attacking zones and centre zone areas as well as a larger defined crease area. Two (2) additonal free play lines (1 in each attacking zone) are also required. Free Play Lines In both attacking zones located above the 30 ft. (9.14 m) circles is a 5.08 cm (2 in.) red “Free Play Line”. These lines shall be installed to completely overlap the top of each of the 30 ft. circles. -
Classification Made Easy Class 1
Classification Made Easy Class 1 (CP1) The most severely disabled athletes belong to this classification. These athletes are dependent on a power wheelchair or assistance for mobility. They have severe limitation in both the arms and the legs and have very poor trunk control. Sports Available: • Race Runner (RR1) – using the Race Runner frame to run, track events include 100m, 200m and 400m. • Boccia o Boccia Class 1 (BC1) – players who fit into this category can throw the ball onto the court or a CP2 Lower who chooses to push the ball with the foot. Each BC1 athlete has a sport assistant on court with them. o Boccia Class 3 (BC3) – players who fit into this category cannot throw the ball onto the court and have no sustained grasp or release action. They will use a “chute” or “ramp” with the help from their sport assistant to propel the ball. They may use head or arm pointers to hold and release the ball. Players with a impairment of a non cerebral origin, severely affecting all four limbs, are included in this class. Class 2 (CP2) These athletes have poor strength or control all limbs but are able to propel a wheelchair. Some Class 2 athletes can walk but can never run functionally. The class 2 athletes can throw a ball but demonstrates poor grasp and release. Sports Available: • Race Runner (RR2) - using the Race Runner frame to run, track events include 100m, 200m and 400m. • Boccia o Boccia Class 2 (BC2) – players can throw the ball into the court consistently and do not need on court assistance. -
Latent Class Analysis to Classify Patients with Transthyretin Amyloidosis by Signs and Symptoms
Neurol Ther DOI 10.1007/s40120-015-0028-y ORIGINAL RESEARCH Latent Class Analysis to Classify Patients with Transthyretin Amyloidosis by Signs and Symptoms Jose Alvir . Michelle Stewart . Isabel Conceic¸a˜o To view enhanced content go to www.neurologytherapy-open.com Received: February 21, 2015 Ó The Author(s) 2015. This article is published with open access at Springerlink.com ABSTRACT status measures for the latent classes were examined. Introduction: The aim of this study was to Results: A four-class latent class solution was develop an empirical approach to classifying thebestfitforthedata.Thelatentclasseswere patients with transthyretin amyloidosis (ATTR) characterized by the predominant symptoms based on clinical signs and symptoms. as severe neuropathy/severe autonomic, Methods: Data from 971 symptomatic subjects moderate to severe neuropathy/low to enrolled in the Transthyretin Amyloidosis moderate autonomic involvement, severe Outcomes Survey were analyzed using a latent cardiac, and moderate to severe neuropathy. class analysis approach. Differences in health Incorporating disease duration improved the model fit. It was found that measures of health Electronic supplementary material The online status varied by latent class in interpretable version of this article (doi:10.1007/s40120-015-0028-y) contains supplementary material, which is available to patterns. authorized users. Conclusion: This latent class analysis approach On behalf of the THAOS Investigators. offered promise in categorizing patients with ATTR across the spectrum of disease. The four- Trial registration: ClinicalTrials.gov number, class latent class solution included disease NCT00628745. duration and enabled better detection of J. Alvir (&) heterogeneity within and across genotypes Statistical Center for Outcomes, Real-World and than previous approaches, which have tended Aggregate Data, Global Medicines Development, Global Innovative Pharma Business, Pfizer, Inc., to classify patients a priori into neuropathic, New York, NY, USA cardiac, and mixed groups. -
Banquet & Event Terms
Banquet & Event Terms Banquet & Event Information Event & Party Ideas Bar & Beverage Packages Appetizers – Display & Passed Dinner Buffets Sports & Group Banquets Party Packages Youth Party Packages Additional Services & Amenities Map & Directions Frequently Asked Questions Example Contract Example Banquet Event Order Games Information House Rules Private and Semi-Private Rooms – We have several Menu - In order for us to provide you with the best service spaces throughout The Wild Game that can be set up possible, we request large parties to use one of our group private or semi-private depending on the needs of your menus. Of course, we will be happy to accommodate spe- group. If you would like to tour or reserve one of these cial vegetarian or dietary needs, as well as design a areas, please contact the Sales Coordinator on site. special menu for your specific event. Your menu must be Signed Contract - All private and semi-private events will finalized at least one week (7 days) in advance of your remain tentative and subject to cancellation until the event. complete signed contract and noted deposit are received Outdoor Functions - In the best interest of our guest, by The Wild Game. The Wild Game reserves the right to move outdoor func- Banquet Fee and Taxes – A Banquet Service Fee of 20% tions inside, if available, on the day of the function due to and all applicable local and state taxes will be added to forecasted weather. The decision made on the day of the the final bill for your event. function is final. Guarantee - The final headcount must be received a min- Room and Table Arrangements - We will do our best to imum of seven (7) days prior to the date of your function accommodate your group in the space preferred by your or event.