Author Manuscript Published OnlineFirst on July 9, 2019; DOI: 10.1158/1535-7163.MCT-18-0791 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. 1 Altered steroid milieu in AI resistant breast cancer facilitates AR mediated gene expression associated with poor 2 response to therapy. 3 Short title: Androstenedione drives AR mediated gene expression in AI resistance. 4 Laura Creevey1* (
[email protected]) 5 Rachel Bleach1* (
[email protected]) 6 Stephen F Madden2 (
[email protected]) 7 Sinead Toomey3 (
[email protected]) 8 Fiona T Bane1 (
[email protected]) 9 Damir Varešlija 1 (
[email protected]) 10 Arnold D Hill4 (
[email protected]) 11 Leonie S Young1 (
[email protected]) 12 ‡Marie McIlroy1 (
[email protected]) 13 1. Endocrine Oncology Research Group, Department of Surgery, RCSI, Dublin 2 14 2. Data Science Centre, RCSI, Dublin 2 15 3. Department of Oncology, RCSI, Beaumont Hospital, Dublin 9 16 4. Department of Surgery, RCSI, Beaumont Hospital, Dublin 9 17 * Both authors contributed equally to this manuscript 18 The authors declare there have been no competing interests. 19 ‡Corresponding author: M. McIlroy (
[email protected]) 20 Endocrine Oncology Research Group. 21 Department of Surgery, 22 Royal College of Surgeons in Ireland, 23 St. Stephens Green, 24 Dublin 2, 25 Ireland. 26 Tel No: 0035314022286 27 Funding: Health Research Board (HRA-POR-2013-276) (MMcI) and BHCRDT (MMcI). 1 Downloaded from mct.aacrjournals.org on September 23, 2021. © 2019 American Association for Cancer Research. Author Manuscript Published OnlineFirst on July 9, 2019; DOI: 10.1158/1535-7163.MCT-18-0791 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.