KCI Hope Summer 05.Indd

SUMMER 2005

HOPEA PUBLICATION OF THE BARBARA ANN KARMANOS CANCER INSTITUTE

Premiere Issue! HILLARY’S STORY: Interior designer beats lymphoma

IN GOOD COMPANY Karmanos Cancer Institute among elite group of cancer centers STATE OF INDEPENDENCE Michigan’s ﬁrst and only independent cancer hospital CRYOTHERAPY PIONEER Innovative breast cancer treatment PRESIDENT’S LETTER

...... SUMMER 2005 VOLUME 1 | NUMBER 1 ......

ABOUT THE INSTITUTE

The Barbara Ann Karmanos Cancer Institute is committed to a future free of cancer. The Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit, operated by the Institute, is one of only 39 National Cancer Institute-designated Comprehensive Cancer Centers in the United States. Federal designation as a Comprehensive Cancer Center is the pinnacle of translational oncology research. The Institute’s physician-scientists, doctors and researchers interact with hundreds of their colleagues across the nation and around the elcome to Karmanos Hope, the new magazine of the world. They consult on patient cases, share Barbara Ann Karmanos Cancer Institute. investigational data and conduct more than 500 cancer-specific scientific studies and clinical The stories you’ll read in these pages are glimpses into our trials. Last year, nearly 6,700 newly-diagnosed Wpeople, our technology and our achievements. These stories cancer patients from 28 states, Puerto Rico will mean different things to different readers. For our volunteers and donors, these and 77 of Michigan’s 83 counties were seen stories will be evidence of a wise investment in our organization. For our cancer at the Karmanos Cancer Institute. patients and their families, these stories will provide hope......

As for the people of the Karmanos Cancer Institute, our hope is for a cancer-free EXECUTIVE STAFF future. In the pages of this magazine, you’ll learn how we recently accomplished two important objectives in our quest. JOHN C. RUCKDESCHEL, M.D. President & CEO After reaching an historic agreement with the Detroit Medical Center, the NICK KARMANOS Karmanos Cancer Institute opened its doors on May 1 as an entirely new Vice President, Development institution. We’re now a stand-alone, independent cancer center – one of the WILLIAM BENNETT few such places in the United States. Our independence will enable us to Chief Financial Officer leverage and translate our research into better patient care. WILLIAM D. BLAUL Vice President, Institutional Relations At nearly the same time, we received a full, five-year renewal of the National Cancer Institute’s “comprehensive cancer center” designation, a prestigious indication ...... of excellence in cancer research. We earned the largest federal grant to operate the center in our nearly 62-year history. BARBARA ANN KARMANOS CANCER INSTITUTE I’m extraordinarily proud of the Institute and the thousands of physicians, 4100 JOHN R nurses, researchers, employees, donors and volunteers whose efforts have made DETROIT, MI 48201 our recent successes possible. www.karmanos.org With this premier issue of Karmanos Hope, we start a new journey in our (800) KARMANOS ongoing fight against cancer. We hope you’ll join us. (1-800-527-6266) Email: [email protected] Sincerely, KELLY C. SCHEER Editor Senior Director, Public Relations and Marketing JACQUELINE TROST Associate Editor Public Relations Specialist John C. Ruckdeschel, M.D......

03 FEATURE IN GOOD COMPANY Karmanos ranks among the nation’s elite cancer centers

A STATE OF INDEPENDENCE Michigan’s ﬁrst and only 08 independent cancer hospital 06 PROGRAMS BONE MARROW TRANSPLANT Innovative new program breaks the age barrier 08 PEOPLE CRYO PIONEER Dr. Peter Littrup investigates cryotherapy for breast cancer 10 INNOVATIONS 10 GROUNDBREAKING THERAPIES Investigating promising new cancer treatments 12 DINNER WITH FRIENDS A FUNDRAISING TRADITION Annual event raises funds for the Institute

14 2003-2004 DONOR LISTS 22 WAYS OF GIVING 23 UP CLOSE: Manuel Valdivieso, M.D. 23 22 NEWS & NOTES 24 AROUND TOWN

HOPE | SUMMER 2005 FEATURE

HOPE

Hillary Waterman

“My mother and I both started crying when we heard the cancer was gone.” InCOMPANY Good The Mayo Clinic. M.D. Anderson. Memorial Sloan-Kettering. Karmanos Cancer Institute. All have earned prestigious recognition from the National Cancer Institute as being among the nation’s elite cancer centers.

When Hillary Waterman was diagnosed with Hodgkin’s affects various populations in Southeast Michigan. Our Lymphoma last year, she didn’t know about the Institute’s job is to keep pushing back this disease.” national reputation as a top cancer research and treatment center. The National Cancer Institute (NCI) designation is more “My only experience with cancer at that point was a friend who’d than just a feather in the Institute’s cap. It provides much been diagnosed and treated for cancer at Karmanos,” she said. “He needed funding for core research projects – the foundation survived and that was a good enough recommendation for me.” of all research at the Institute. The funding – called a “core grant” – also drives cross-departmental communication and After a few visits to the Karmanos Cancer Institute, Hillary synergy, which facilitates a fully integrated approach to cancer knew it was a special place. (See Hillary’s Story below.) She investigation and innovative treatment. received innovative treatments and personal attention from Earning the NCI designation is not easy. The review process is a multidisciplinary team of Hodgkin’s Lymphoma experts rigorous. The NCI designation recognizes scientific excellence – men and women on the forefront of cancer research. Her at Karmanos – excellence in research, institutional leadership team is one of 14 teams of physician researchers at Karmanos, and management. each focusing on a different type of cancer. While more than 2,500 patients are currently enrolled in It’s this combination of cancer research and focused patient care clinical trials at Karmanos, other patients – like Hillary that recently resulted in a prestigious five-year grant renewal for Waterman – benefit from research conducted at Karmanos the Institute’s Meyer L. Prentis Comprehensive Cancer Center without ever participating in clinical trials. of Metropolitan Detroit – one of only 39 federally designated comprehensive cancer centers in the United States. “Today’s conventional treatments were yesterday’s research and clinical trials,” said Dr. Ruckdeschel. “Only a handful of “Research is at the core of the Karmanos mission,” said institutions in the nation can take research from the laboratory John C. Ruckdeschel, M.D., president and CEO of and start applying it to patients and then take the results back Karmanos Cancer Institute. “We are charged with conducting to the laboratory to refine. We are one of them.” research, advancing the field and studying how cancer

HILLARY’S STORY Hillary Waterman is an active, 26-year-old interior designer. She’s always At the end of her chemo, Dr. Zonder ordered a series of scans to been in good physical condition, so early in 2004,when she developed a determine the size of the mass. “It was amazing. The mass was “tight” feeling in her chest she didn’t give it much thought. completely gone. There was nothing left, not even scar tissue. It was “My job is fairly demanding so I just thought it was stress,” she said. the best case scenario,” Hillary said. “My mother was with me for that But it wasn’t. Weeks later a CT scan revealed a large mass above appointment and we both started crying when we heard it was gone.” her heart. It was Hodgkin’s Lymphoma. To maximize the chances of curing the lymphoma, Dr. Zonder and Based on the recommendation of a friend, Hillary called the Jeffrey Forman, M.D. – a radiation oncologist at Karmanos Cancer Karmanos Cancer Institute in Detroit. She scheduled an initial Institute – completed Hillary’s treatment protocol with 20 days of appointment with one of the Institute’s lymphoma specialists – radiation therapy at Karmanos Cancer Institute’s Lawrence and Idell Jeffrey Zonder, M.D. – within a week of her call. Weisberg Cancer Treatment Center in Farmington Hills, Michigan. “I immediately loved Dr. Zonder,” she said. “Even when I knew he Today Hillary lives on a lake in Linden, Michigan and feels great know- was busy, he took time to explain everything to me.” ing that she’s healthy again. But, in truth, she says she never really felt ill. That was important because Hillary was entering one of the most challenging periods of her life. In the summer of 2004, she started “That’s the scariest thing. I never felt sick,” she said. “I guess I’m 16 weeks of chemotherapy at the Karmanos Cancer Institute. lucky I found it when I did.” And, she says, she’s lucky she found She met many “fantastic nurses” during that time – people she Drs. Zonder and Forman and all the dedicated people at Karmanos says would “do anything for you.” Cancer Institute. AINDEPENDENCE State of Agreement Advances Metro Detroit’s Cancer Programs

armanos Cancer Institute just took a giant step care advocates in the community are welcoming the move toward its goal of becoming one of the nation’s as a very positive step for the region. top ten cancer centers. Karmanos is now K “It’s wonderful to see the Detroit Medical Center and the Michigan’s only independent cancer institute – initiating a new relationship with the Detroit Medical Center (DMC). Karmanos Cancer Institute working together to create an independent cancer center owned and operated by the “The Detroit Medical Center has been a part of everything Institute,” said Vernice Davis Anthony, president and CEO we do here since the founding of the Institute, but being of the Greater Detroit Area Health Council – a health care part of a larger operation didn’t always enable us to focus coalition that addresses issues of health care quality, access our resources exclusively on cancer,” and cost in southeastern Michigan. said John C. Ruckdeschel, M.D., “A vibrant and growing Karmanos president and CEO of Karmanos Cancer Institute is excellent news Cancer Institute. “We decided many Karmanos Cancer for cancer patients throughout years ago that the best thing to do Metro Detroit and across Michigan. would be to separate the Institute’s Institute will be one I think we’ll see significantly more patient care from the DMC to cre- “ investment in groundbreaking ate a new Karmanos Cancer Center of the top ten cancer cancer research.” as a fully independent, freestand- ing clinical operation – to work in centers in the nation The agreement opens the door collaboration with the DMC rather within five years. than work as part of it.” to make great strides in cancer research and patient care. FOCUSED ON CANCER That’s the goal. According to Karen Goldman, The agreement is the beginning of — Dr. John C. ”Ruckdeschel vice president of patient services a new era for Karmanos. President and CEO at Karmanos Cancer Institute, this new independence enables The Institute recently acquired management to focus exclusively the clinical cancer facilities that on the needs of cancer patients Karmanos and the DMC have and their families. jointly managed since 1994. The purchase and long-term lease COMMITTED TO GROWTH transaction involves the Karmanos Cancer Center on the DMC’s main campus and the Lawrence and Idell Weis- During the next five years, Karmanos plans to develop a berg Cancer Treatment Center in Farmington Hills. comprehensive cancer center focused on same-day service. Patients will arrive in the morning with a preliminary diag- “This is a major step forward to ensure the campuses nosis of cancer and leave that day with a complete diagnosis, in midtown Detroit and Farmington Hills will grow recommended treatment plan and appointment schedule. and thrive as centers of world-class cancer research and patient care,” Dr. Ruckdeschel said. “We need a cancer-only surgical pavilion that allows us to have the latest in robotics and other state-of-the-art The agreement gives Karmanos control over its own equipment,” Dr. Ruckdeschel said. “We need a diagnostic facilities, technology and staff, while maintaining a strong, suite of the latest equipment so we can move patients working relationship with the DMC. And, importantly, in and out quickly and solve their problems the same it further cements an already solid affiliation with the day – that’s vital to what we do.” Wayne State University School of Medicine. Health

4 HOPE | SUMMER 2005 CAPITAL FUNDS In Action The Karmanos Cancer Institute is planning many facility and technology improvements, including a $47-million clinical expansion and:

• New state-of-the-art operating rooms fully equipped for robotic and microsurgery • A diagnostic imaging suite using the latest available technology in magnetic resonance imaging (MRI), computerized axial tomography (CT) scans and positron-emission tomography (PET) scans – all in one location and dedicated to the needs of cancer patients • Same-day service. Patients will arrive in the morning with a preliminary diagnosis of cancer and leave that day with a complete CANCER SURVIVOR HILLARY WATERMAN MEETS WITH JEFFREY FORMAN, M.D., MEDICAL DIRECTOR OF THE INSTITUTE’S LAWRENCE AND IDELL WEISBERG diagnosis, recommended treatment CANCER TREATMENT CENTER IN FARMINGTON HILLS, MICHIGAN. plan and appointment schedule • All private inpatient rooms with enhanced nursing coverage NATIONAL RECOGNITION appropriate to a world-class cancer center Independent status elevates the stature of the Karmanos Cancer Institute • An expanded area for testing the on a national level. For instance, when magazines such as US News and latest cancer treatment drugs under World Report rate hospitals, they can now evaluate Karmanos separately Phase 1 clinical trial protocols as a cancer center, alongside other independent cancer institutions like M.D. Anderson Cancer Center in Houston and Memorial • A total renovation of the Gershenson Sloan-Kettering in New York. Radiation Oncology Center, including a next-generation Tomo- And it doesn’t stop there. This new relationship with the DMC also Therapy radiation treatment system allows Karmanos to independently recruit and retain the world’s • Upgraded clinical facilities to leading cancer physicians and scientists and provide them with improve patient comfort and state-of-the-science facilities and groundbreaking technology. operational efficiency According to Dr. Ruckdeschel, the overall goal is to make Karmanos one of the nation’s top ten cancer centers within five years. In addition to extensive facility and technology improvements, the Institute “This should be the place to go for cancer in the upper Midwest – plans a dramatic expansion of its bar none,” Dr. Ruckdeschel said. “We’re talking about competing with prostate cancer patient care and the Mayo Clinic, with Northwestern University in Chicago, and the research program while also creating Cleveland Clinic. That’s who we will be in a league with. And when additional endowments to support people have cancer and they say, ‘I need to go get a second opinion,’ and advance the fight against cancer. Karmanos will be one of the places that immediately comes to mind.”

HOPE | SUMMER 2005 5 NEVER TOO OLD INNOVATIVE BONE MARROW TRANSPLANT PROGRAM BREAKS THE AGE BARRIER

At 69, Pauline Lather was losing her battle with leukemia. A stem cell transplant was her only hope. But most bone marrow transplant programs in the country considered her too old for treatment – most, but not the bone marrow transplant experts at Karmanos Cancer Institute.

“They told me age was against me, but they thought ”We tailored the intensity of the regimen so she could I’d have a chance,” said Pauline Lather, a native of handle it. Most other programs would have just said Traverse City, Michigan. “And at that point – when no to someone her age,” said Dr. Ratanatharathorn. you don’t have other options – a chance sounds “Usually people say that 60 years old is too old for this type pretty good.” of transplant. But we don’t have an age limit. It depends on the individual patient.” Pauline and her husband, David, drove downstate to meet Of only four bone marrow transplant programs in with Voravit Ratanatharathorn, M.D., team leader of Michigan, Karmanos Cancer Institute’s program is the Karmanos Cancer Institute’s Bone Marrow Transplant largest – treating more patients than any other program in (BMT) program, and Joseph Uberti, M.D., Ph.D., the state. Stem cell transplant outcomes at the Institute are co-leader of the BMT team. After meeting Pauline consistently among the best in the nation. and learning that she was in excellent physical condition despite her disease, the physicians developed an The Institute operates Michigan’s only cord blood bank – a innovative, customized treatment plan. program that collects umbilical cord blood for use in stem

The Bone Marrow Transplant Multidisciplinary Team at the Karmanos Cancer Institute. CORD BLOOD VORAVIT STEM CELL RATANATHARATHORN, M.D. TRANSPLANTS

When a baby is born, the umbilical BONE MARROW TRANSPLANT RECIPIENT AND CANCER SURVIVOR cord and placenta are often just thrown PAULINE LATHER AND HER HUSBAND DAVID LATHER. away. It’s a shame – according to Dr. Ratanatharathorn and the BMT team at Karmanos – since stem cells from cord cell transplants. Stem cells from cord blood are remarkably flexible and blood could save the lives of countless can be used in stem cell transplants with adults, even if the adult is cancer patients. not an exact match with the donor. (See Cord Blood Stem Cell Transplants “The stem cells of cord blood are more on page 7). flexible, more malleable than stem cells The Karmanos BMT team uses a comprehensive, multidisciplinary from adults,” said Dr. Ratanatharathorn. team approach to evaluate and treat candidates for bone marrow and “So stem cells from cord blood do not have peripheral blood stem cell transplants. The program utilizes the most to be a precise match with the recipient.” technologically advanced transplant methods. For a patient who can’t find an exact Patients at Karmanos often have the opportunity to participate in clinical match from an adult stem cell donor, trials. Investigators are currently studying reduced intensity regimens, the cord blood can mean the difference prevention and treatment of graft-versus-host disease, and new ways to between life and death. prepare patients for transplantation. Karmanos Cancer Institute operates It’s this level of expertise that enabled Pauline Lather to receive an Michigan’s only cord blood bank. U.S. innovative stem cell transplant with stem cells donated by her 44-year-old Representative Carolyn Cheeks Kilpatrick son. Pauline received her transplant in October 2004 and according to of Michigan’s 13th Congressional district Dr. Ratanatharathorn she is doing extremely well. recently presented Karmanos Cancer Institute with a check representing “We had a lot of things going for us. I’m very thankful my son was a $929,000 in federal funding to support its match and I’m so lucky to have found such wonderful doctors,” she said. Cord Blood Stem Cell Program.

Dr. Ratanatharathorn expects cord AN EXPERT TEAM blood transplants to become increasingly The multidisciplinary bone marrow transplant team at Karmanos important in the coming years. “Cord includes experts from a variety of medical specialties. blood transplantation is limited now by • VORAVIT RATANATHARATHORN, M.D. – Hematology and the inventory of the cord blood banks,” Medical Oncology said Dr. Ratanatharathorn. “We have to • MUNEER ABIDI, M.D. – Hematology and Medical Oncology build the inventory so we can distribute • LOIS AYASH, M.D. – Hematology and Medical Oncology more cord blood to transplant centers • EDWARD PERES, M.D. – Hematology and Medical Oncology around the world.” • AYMAN SOUBANI, M.D. – Pulmonary Medicine His message to pregnant women and • JOSEPH UBERTI, M.D., PH.D. – Hematology and Medical Oncology • GEORGE ALANGADEN, M.D. – Infectious Diseases obstetricians is clear: Save lives by • PRANATHARTHI CHANDRASEKAR, M.D. – Infectious Diseases donating umbilical cords and placentas to the Institute’s cord blood bank. The team also includes representatives from the Institute’s Clinical Trials Ofﬁce. CRYO PIONEER

In 1992, he led clinical trials of an innovative technique that uses extreme cold to destroy prostate cancer. Since then he’s been one of the nation’s ﬁrst to use the technique – called cryotherapy – to treat liver, lung, kidney, and now, breast cancer. Peter Littrup, M.D. is a Cryo Pioneer.

hile cryotherapy has been around for a the future. It has the potential to essentially teach the patient’s long time – dermatologists have used it for immune system to fight off similar types of cancer. years to freeze warts – Peter Littrup, M.D., W Cryo is one of many options for destroying a tumor professor of radiology, urology and radiation oncology at the without surgery. One of those options is called Radio Karmanos Cancer Institute, is one of the first physicians in Frequency Ablation, which kills the tumor with a the nation to use it for the treatment of cancer. hot electrical current. But Dr. Littrup prefers cold to Cryotherapy uses highly compressed argon gas to freeze hot for many reasons. a mass to extremely cold temperatures – from minus 20 to “With cryo I can see the actual ice forming. When I put minus 40 degrees Celsius. The high-pressure gas is delivered a needle into the tumor and an ice ball forms at the end to the tip of a probe placed into the core of a tumor through of the probe, I know that I got the treatment zone bigger a small incision in the patient’s skin, using ultrasound or CT than the tumor zone,” Littrup said. “It kills the tumors guidance. The extreme temperature freezes the mass in place, in place with a nice, smooth rim.” where it’s then reabsorbed into the body through normal healing processes. This reabsorption of dead cancer cells may His work suggests that patients heal more quickly following provide an additional benefit called the “immune effect” in a cryo procedure and experience less pain and discomfort

8 HOPE | SUMMER 2005 than with heat treatments. That lends itself to treating chronic or recurring tumors. Plus, cryotherapy can kill cancerous tumors without doing much damage to the surrounding tissue. That was appealing to artist Laura Ross-Paul from Portland, Oregon. When she was diagnosed with breast cancer in 2003 and urged to have a mastectomy, she was terribly concerned about losing her breast.

“As a painter and a teacher, I’m around nude models every day,” she said. “I’m used to see- ing the body in its natural form and the idea of losing my breast and having a surgeon try to reconstruct it was just not appealing to me.” ARTIST AND BREAST CANCER SURVIVOR LAURA ROSS-PAUL IS She wanted alternatives. But her physicians THANKFUL TO DR. LITTRUP AND KARMANOS CANCER INSTITUTE. in Oregon didn’t offer any. That’s when her husband, Alex, went to work. He spent hours in the world to receive cryo treatment for breast cancer. searching the Internet, often in the middle of the night, trying to find a way for Laura to beat the “Laura is really a pioneer in that she chose cryosurgery cancer and save her breast. After days of searching, over other options,” Dr. Littrup said. “We’ve been he found Dr. Littrup at Karmanos Cancer Institute. treating prostate cancer with cryotherapy for years, but when it comes to breast cancer it’s a new approach.” “The thing that was so appealing about cryo is that it doesn’t break down the infrastructure of the breast,” “I was beyond happy with the results. It was truly a Laura said. “So your nerves, your ducts, your veins miracle,” Laura said. “My goal was to keep my breast and are still intact after the procedure.” survive. I did that, and there’s probably no other place on the planet where that could have happened.” In April 2003, Laura flew to Detroit for the procedure as part of a clinical trial – making her one of the first women Today, Laura is cancer-free and healthy. She has more energy now than she’s had in years. And it’s influenced her art. While her I was beyond happy with the results. paintings used to be created with “a It was truly a miracle. My goal was certain amount of angst,” she says her “ work now is a celebration of life. to keep my breast and survive. I did “I feel like I got my life handed back to me and I’m not going to let it go that, and there’s probably no other to waste,” Laura said. “I’m just so place on the planet where that could thankful to Karmanos and Dr. Littrup for keeping at this and trying to find have happened. better ways to treat cancer.” ” –LAURA PAUL ROSS

HOPE | SUMMER 2005 9 CLINICAL TRIALS

T he Karmanos Cancer Institute discovers, reﬁnes and delivers innovative cancer treatments to the world – and clinical trials are a vital part of this eﬀort.

As Michigan’s only Phase I clinical trials program and one of Innovative only 16 research centers in the United States to participate in the National Therapies Cancer Institute’s Cancer Therapy Evaluation Program (CTEP), the Institute is recognized as a national leader in testing new cancer therapies.

Currently conducting more than 500 cancer-speciﬁc scientiﬁc investigations and clinical trials, following are a few of our more than 250 active clinical trials:

AGGRESSIVE TREATMENT FOR A RARE FORM OF LUNG CANCER

Physician-scientists at the Karmanos Cancer Institute are conducting a clinical trial of an aggressive treatment for pleural mesothelioma.

Pleural mesothelioma is a rare form of cancer in which cancer cells develop in the lining of the chest. Most reported cases of the disease are associated with asbestos exposure.

The Institute is one of several cancer centers participating in a Phase II clinical trial of a drug called ALIMTA, used in conjunction with another drug called cisplatin. Considered to be the most aggressive treatment available, all patients with pleural mesothelioma should be considered for the trial.

According to the FDA, patients who were treated with ALIMTA and cisplatin had a median survival of 12.1 months compared to 9.3 months for patients treated with cisplatin alone. This trial will evaluate the eﬀectiveness and feasibility of treating patients with a combination of ALIMTA and cisplatin followed by surgery and post-operative radiation therapy. The study, spread over eight sites, will involve approximately 77 patients.

10 HOPE | SUMMER 2005 THREE-DRUG TREATMENT FOR AGGRESSIVE COLORECTAL CANCER

Physician-scientists at Karmanos Cancer STUDY OF TREATMENT TO Institute are studying a combination of three PREVENT LUNG CANCER drugs in treating advanced colon or rectal cancer. Physician-scientists are studying a treatment which may prevent lung cancer in patients This Phase II study evaluates the effectiveness of a with a high risk for the disease. three-drug chemotherapy regimen in patients with colorectal cancer. The current standard therapy involves Zileuton is a drug that is commonly used to treat asthma treatment with two chemotherapy drugs called in children. But physician-researchers at Karmanos 5-fluorouracil and irinotecan. Researchers at Karmanos Cancer Institute are currently studying the drug to are studying the effects of adding a third drug called determine if it may be effective in preventing lung celecoxib to the standard therapy. cancer in current or former smokers.

The third drug, celecoxib (better known as Celebrex), According to the study’s primary investigator, Omer is a COX-2 inhibitor. In laboratory and animal models, Kucuk, M.D., zileuton has been shown in animal studies celecoxib blocks the generation of new blood vessels to prevent lung cancer. However, this is the first clinical that support tumor growth. In animal studies, celecoxib cancer prevention study with zileuton. has been shown to increase the effectiveness of the two-chemotherapy drug regimen. Zileuton is a 5-lipoxygenase (5-LO) inhibitor, a class of molecules that is being actively investigated Patients enrolled in this study will receive 400 mg of worldwide for potential uses in cancer therapy as Celebrex (celecoxib) twice a day for the duration of the well as the prevention and treatment of inflammation trial. Simultaneously, the standard chemotherapy drugs and respiratory diseases. – capecitabine and irinotecan – will be administered in 21-day cycles. Patients will be evaluated at least once a Candidates for the study are individuals at a high risk week for side effects and the effectiveness of this therapy of developing lung cancer. As part of the study, people will be evaluated using computed tomography (CT) identified as high risk will be examined to identify scans after every two cycles. any premalignant cells in the lungs.

Patricia LoRusso, D.O. is director of the Institute’s Phase I Clinical Trials Program, the only Phase I clinical trials program in Michigan.

HOPE | SUMMER 2005 11 ANNUAL EVENT A FUNDRAISING TRADITION

With the Karmanos Cancer Institute’s recent aqusition of by just taking care of current patients. We need to get more its patient care facilities, the Annual Dinner took on added dollars into research.” importance this year. Held on Saturday, May 14 at Ford Field in Detroit, the According to the chairs of the annual event – Jinny and Annual Dinner featured Detroit radio personality Dick Purtan Don Runkle – the Institute’s independence provides new as master of ceremonies. The evening included a tribute to fundraising opportunities. local real estate developer Burt Farbman and his wife, Suzy, for their commitment and generosity to Metro Detroit. “It’s a new starting point for the Institute – a kind of ‘Year One’ – and it’s great to be involved during this transition,” In planning the event, the Runkles and their co-chairs said Don Runkle, former vice chairman of Enterprise – Kim DelGrosso and Dayle Hoffecker – wanted to strike Technologies at Delphi Corporation. His wife, Jinny, a a balance between fundraising and entertainment. “We former auto executive, now spends most of her days wanted to net as much as possible from this event for working with charitable groups including the Institute. Karmanos while still making it an evening people would enjoy and remember,” Don said. “It’s an important time for Karmanos because of the agreement with the DMC and future plans for By all counts, the event chairs succeeded in their efforts. Money fundraising,” Jinny adds. raised from the Annual Dinner will fund cancer research and patient care programs at Karmanos Cancer Institute. “Cancer affects everyone,” said Jinny. “We lost a family member three years ago. If we’re going to win the fight, there Jinny and Don Runkle is so much research yet to happen. It isn’t going to happen “Cancer affects everyone...we need to get more dollars into research.” SEATED LEFT TO RIGHT: DAYLE AND JOHN HOFFECKER, CO-CHAIRS ALIXPARTNERS; SUZY AND BURTON FARBMAN, HONORARY CHAIRS. STANDING LEFT TO RIGHT: DOUGLAS AND KIM DELGROSSO, CO-CHAIRS LEAR CORPORATION; DR. AND MRS. JOHN RUCKDESCHEL, KARMANOS CANCER INSTITUTE; MIKE AND LORI DUGGAN, DETROIT MEDICAL CENTER. BACK ROW STANDING: JINNY AND DONALD RUNKLE, DELPHI CORP AND EVENT CHAIRS.

ABOVE: HONORARY CHAIRS, SUZY AND BURTON FARBMAN WITH KARMANOS CANCER INSTITUTE PRESIDENT AND CEO JOHN C. RUCKDESCHEL, M.D., CELEBRATE THE EVENING’S SUCCESS.

RIGHT: JEROME HOROWITZ, PH.D., VAINUTIS VAITKEVICIUS, M.D., AND SAMUEL C. BROOKS, PH.D. (SEATED LEFT TO RIGHT) WERE HONORED FOR THEIR MANY YEARS OF DEDICATED SERVICE, LEADERSHIP AND PATIENT CARE AT THE KARMANOS CANCER INSTITUTE.

HOPE | SUMMER 2005 13 There’s a story behind every gift to the Karmanos Cancer Institute. Some give to honor the memory of a loved one. Others give out of gratitude for the outstanding care they received. Some give because Karmanos is one of the nation’s top cancer research centers. Whatever the reason, we are very grateful for their support. The Institute’s generous donors are listed in the following pages as well as their cumulative giving to the Institute in 2003 and 2004.

2003 We’re working for a cancer-free future…and we can’t do it without you.

ABOVE $1,000,000 $10,000 - $24,999 Ms. Olive Schmidt Mr. and Mrs. Hank Jallos

ONORS Peter J. Karmanos, Jr. *Accenture Shelby Enterprises, Inc. *Johnson & Johnson $500,000 - $999,999 Ackerman & Ackerman, P.C. Ms. Joan K. Slocum Mr. Mark S. Kahn D Mr. and Mrs. Randolph J. Agley SPX Corporation Mrs. Irene H. Kalman Edward C. Levy, Jr. Arbor Investment Group, LLC Star Trax Corporate Mr. and Mrs. Jason R. Karmanos $100,000 - $499,999 Blue Cross Blue Shield Takata Inc. Mr. and Mrs. Peter Karmanos, III of Michigan Taubman Centers Mr. and Mrs. Martin Kellman Community Foundation for Blue Water Technologies Southeastern Michigan Turner Construction Company Kinko’s Children’s Leukemia Foundation Edward M. & Henrietta M. Unique Restaurant Corporation Ms. Denise A. Knobblock of Michigan Knabusch Charitable Trust *Visual Image Exchange *Kroger Company of Michigan Mr. and Mrs. Michael Chirco Estate of Alice Begwin Walbridge Aldinger Company The Kroger Co. Foundation Comerica Incorporated Estate of Margaret Sarvis Webasto Roof Systems, Inc. Mrs. Arola Lemmen Cornish, Zack, Hill & The London and Mary Morawski $50,000 - $99,999 $5,000 - $9,999 Associates, Inc. Charitable Foundation Anonymous Dana Corporation AIREA The R. C. Mahon Foundation Compuware Corporation Deloitte Touche LLP Mr. and Mrs. Jeffery Alasina *Marshall Field’s Credit Union ONE Costantino DelSignore 2003Allstate Insurance, Co. *Metro Detroit Ford Dealers Foundation Estate of Carmel Brock American Cancer Society Mr. and Mrs. Ronald Meyer The Display Group Estate of Margaret Eaegle Dennis Archer Community Brian Minbiole, Callaway Golf Dura Automotive Systems, Inc. Gemellaro Companies, Development Fund NFL Alumni Association Edward C. Levy Company GSI and G & S Electric *AstraZeneca Northwest Airlines Mr. and Mrs. Aleksandar Erdeljan Automobile Club of Michigan General Motors Corporation Mr. and Mrs. Maurice Pagoda Estate of Thelma Ayers Mrs. Betty Jean Awrey Julie and Edward C. Pentastar Aviation, LLC Levy, Jr. Foundation Estate of Alice Bendever Mr. and Mrs. Jeffrey S. Barker PrintMasters Printing Company September Moon Estate of Bernadine Elizabeth Lee Baskin Law Firm, P.C. PVS Chemicals, Inc. Production Network, Inc. Estate of Carolyn Pacheco *Binson’s Home Health Care Centers Ramser-Morgan Foundation Mr. and Mrs. Gilbert B. Silverman Estate of Rosemarie Reinhardt Mr. and Mrs. Bruce E. Braverman Ruth F. Rattner and Ann F. & The Sylvester Family Trust Eurest Dining Services Compass Group, Ltd. Norman D. Katz Foundation Women’s Committee Ford Motor Company Fund Continental Teves, N.A. Mrs. Irene Ruczynski for Hospice Care Mr. and Mrs. Stanley Frankel Steven Cruchon Charities Schechter Financial Group General Motors Acceptance $25,000 - $49,999 Dr. and Mrs. C. Arnold Curry Seligman Family Foundation Corporation CVS Pharmacy, Inc. American Axle and *Smith Barney Mr. Gary Gilbert Delphi Corporation Manufacturing Holdings, Inc. SMZ Advertising Debbie and Mark Gorenberg Mr. and Mrs. John DelSignore Dr. and Mrs. Donald C. Austin Mr. and Mrs. Michael Soave Greekstock Detroit Rotary Foundation Charity Motors, Inc. Mr. and Mrs. David Thewes Mr. and Mrs. E. Jan Hartmann The Diez Group *Compuware Corporation Tiffany & Co. HoMedics, Inc. *Dykema Gossett PLLC DaimlerChrysler Mr. Gary Tisdale Hour Detroit Mr. and Mrs. Kenneth Eisenberg Corporation Fund TraveLeaders *J. Walter Thompson Company Mr. Markus M. Ernst Detroit Free Press Tweedy, Browne Company LLC Jules R. Schubot Jewellers Estate of Jessie Birch Estate of Florence UBS Financial Services Inc. Mr. and Mrs. Nick Karmanos Estate of Irene Carter Bissonnette *UPS Mr. Alexander Krezoski Estate of Sadie Girardot Estate of Irene Gillette Mr. and Mrs. Giovanni Vitale Ms. Joan J. Kughn Estate of Dorothy Kern Estate of Mary S. Irwin Mr. and Mrs. Kenneth L. Way *Lapides Publicity Group Estate of Joan M. Stenzel Estate of Harry Korman Worthington Industries, Inc. Estate of Doris Ressler Mr. and Mrs. Nicholas Lekas Ida M. Faigle Charitable Foundation Estate of Herbert Ressler Mr. Joseph McCray Mr. Ned Fawaz $1,000 - $4,999 Estate of Nellie Stone The Meigray Group Forbes Company AAA Life Insurance Company *Fiji Water Michigan Public Health Institute Fraternal Order Of Eagles 3996 Mr. Allan R. Adelson Samuel and Jean Frankel Molinello Family Foundation Mr. and Mrs. Harold Friedman African American Parent Foundation Ms. Evelyn M. Mulso Mr. James L. Gerback Publishing, Inc. Mr. and Mrs. Stephen Grand Mr. and Mrs. Lee Munder *Got Milk? Randolph J. and Judith A. Hermelin Family Plunkett & Cooney, P.C. Grace & Wild, Inc. Agley Foundation Support Foundation PricewaterhouseCoopers, LLP Greater Detroit Bowling Assn. Mrs. W. Kay Agney Mr. and Mrs. Bernard Lee Hartman Pummill Cancer Golf Classic Mr. Philip Gross Agree Realty Corp. Anna and Harry B. Korman Quicken Loans Haworth Aim Industrial Group, Inc. Foundation Radiation Oncology Research and Mr. and Mrs. Peter Helman Dr. Terrance L. Albrecht and Lear Corporation Development Center Honigman Miller Schwartz Dr. Louis A. Penner Standard Federal Bank Mr. and Mrs. Milton H. Ring and Cohn, LLP Ms. Sandra L. Alfaro U.S. Equities Realty, L.L.C. Mr. Mel B. Rosenhaus Huntington Bank Mr. and Mrs. Robert A. Allesee

14 HOPE | SUMMER 2005 D American Blind & Wallpaper Factory Mr. James H. Carnagie Mrs. Thelma S. Feuerman Ms. Mary Minnick Jurmu Amgen, Inc. Mr. and Mrs. Armando R. Cavazos Mr. Edward S. Fici Drs. Howard and Mary Kaplan ONORS Amit-American Italian Central Woodward First American Title Mr. A. William Kapler III Professional Women’s Club Christian Church Insurance Company Ms. Faye A. Kapler The Anderson Group, Inc. Dr. and Mrs. Jerome V. Ciullo Mr. and Mrs. David T. Fischer Mr. and Mrs. Bruce Kaye Mr. and Mrs. Thomas Andris Mr. Thomas Clark Mr. Max M. Fisher Ms. Patricia D. Kelly

Mr. and Mrs. Thomas V. Angott, Sr. Clawson Fraternal Five Lakes Manufacturing, Inc. Joseph D. & Suzanne G. Kelly 2003 Ann Arbor Area Order of Eagles Mr. and Mrs. Sidney Forbes Family Foundation Community Foundation Clear! Blue Detroit, LLC Dr. and Mrs. Jeffrey D. Forman Kelly Services, Inc. Mr. and Mrs. Gebran Anton Mr. John S. Cleary Mr. William J. Fowler Kenwal Steel Corp. Mr. and Mrs. Joseph E. Antonini Mr. and Mrs. James A. Clement Mr. and Mrs. Aaron Keith Fox Mrs. Judy Kepes APC Group, Inc. Mr. and Mrs. Charles M. Clute Mr. and Mrs. David Frank Mr. Patrick J. Kerzic Mr. and Mrs. Eugene Applebaum Mr. and Mrs. John Cocciolone Dr. and Mrs. H. F. Gallasch, Jr. Ketchum, Inc. Arab Community Center for Colburn Colburn & Associates The Geist Foundation of Michigan Klai Juba Architects Economic and Social Services Colburn Group GenCorp Foundation Ms. Patricia Kluske Artcraft Inc. Coloplast Mr. and Mrs. David C. Gentry Mr. Brian Kramer Artisan Associates, Inc. Comcast Corporation Mrs. Stephanie M. Germack KT Sales, Inc. Arts Beats & Eats Foundation Comerica Bank Mr. and Mrs. Bruce Gershenson Mr. Chris M. Kurzweil Mr. Anthony Asher Commercial Building Mr. and Mrs. Byron H. Gerson Dr. and Mrs. Jerome Kwartowitz Maintenance Co. 8-97 Atsalis Brothers Painting Mr. and Mrs. Yousif B. Ghafari Mr. Sherwyn J. Labovitz Dr. and Mrs. Ralph R. Cook Automation Technologies Council Mr. and Mrs. William B. Gilbert Ladies Gross Open Coppertree Apartments, L.P. Mr. and Mrs. Martin Bader Mr. and Mrs. Alan L. Gilman Ladies of Livonia Transmission Craig Richard Promotional Ms. Elaine R. Baker GKN Automotive Mr. and Mrs. William Laimbeer, Jr. Ms. Cindy Ball Products, Inc. Ms. Debra Glendening-Karmanos Lake Shore High School Mrs. Sonny Barnett Crain Communications, Inc. The Goalie’s Den Mr. and Mrs. Daniel Lass Cranbrook Development Office Bayview Yacht Club Mrs. Eleanor Golden-Zuppke Mr. Harold Croswell Mr. and Mrs. John Paul Lathers BBK Dr. and Mrs. James Gordon Mr. and Mrs. Sante M. Cundari The Law Firm of John F. Schaefer Mr. and Mrs. Larry Becker Gordon Chevrolet, Inc. Custom Homes by Derocher, Inc. Law Offices of Matthew Mr. and Mrs. Charles E. Becker Mr. and Mrs. Gregory T. Grabowski Broderick, PLC Cuzzens Credit Bureau Mr. and Mrs. George Bellinger Great Lakes International Recycling Mr. and Mrs. John Laws D.O.C Optics Corporation Mr. Jeffrey Bergeron Mrs. Freida R. Greene LDM Technologies, Inc. Dakota Inn, Inc. Mr. and Mrs. Dennis S. Bernard GreenPath, Inc. Leggett and Platt/Schukra of Dr. George Dambach Dr. and Mrs. John Bielawski Mr. and Mrs. Fred E. Greenspan North America LTD Damman Hardware Big Boy Franchise Management LLC Grier and Copeland Ms. Cynthia Leigh Ms. Barbara R. Darga Mr. and Mrs. Bruce E. Bigler Groen, Kluka & Company Dr. and Mrs. Barnet L. Leland David Robinson Company Binson’s Home Haden Schweitzer Corporation Ms. Marjorie Griffin Lesher Health Care Centers Degele Manufacturing, Inc. Ms. Elizabeth Hardy Dr. Melvin Lester Ms. Bethany DelVlaminck Binson’s/Able Orthopedics, LLC Mr. and Mrs. Seymour J. Levine Detroit Marriott Renaissance Mrs. Hugh G. Harness The Birchwood Farms Dr. and Mrs. Kim Khong Lie Golf & Country Club Detroit NAACP Dr. Deborah Hartmann and Staff Mr. and Mrs. Glenn Liebowitz Birmingham Chrysler Detroit Tigers, Inc. Health Science Communications, Inc. Mr. Carlton R. Lindell Plymouth Jeep Eagle, Inc. Detroit Women’s Bowling Hella North American, Inc. Mr. Timothy S. Blair Association, Inc. Henry Ford Health Systems, Inc LoanGiant Mr. James T. Blake Mr. Marty Deutch Mrs. Doreen N. Hermelin Mr. Ernest Lofton Mr. and Mrs. Stephen R. Bloom DFCU Financial Mr. and Mrs. Brian Hermelin Loomis, Sayles & Company, LP John A. and Marlene L. Dietech Tool & MFG., Inc. Hines Interest Limited Partnership Mr. Alphonse S. Lucarelli Boll Foundation The Honorable and The Home Accessory Warehouse Mr. Ned Lutz Mr. and Mrs. Paul Borman Mrs. John D. Dingell Hospice of Michigan Mr. and Mrs. Robert A. Lutz Borman Fund Doeren Mayhew & Co., P.C. Hoveround Corporation LVC Technologies, Inc. Kathryn Bracken Anderson Fund Mr. and Mrs. William S. Doll Mr. and Mrs. Joseph L. Hudson, Jr. Dr. and Mrs. David Madorsky Mr. Paul A. Bringer Dr. and Mrs. David Goodman Hurley Binson Medical The Magni Group, Inc. Bristol Steel & Conveyor Corporation Mr. Joseph Dresner and Equipment, Inc. Mr. and Mrs. Walter H. Makupson Dr. and Mrs. Burton Brodsky Mr. Milton Dresner Mr. and Mrs. Ronald Hurt The Maniscalco Gallery Mr. Robert D. Brody Irv and Olga F. Dworkin Hutzel Hospital Mrs. Carol E. Mann Mr. Fred A. Bunting Education Preferred Corporation Mr. Robert B. Hwacinski Mr. and Mrs. Mervyn Manning Mr. and Mrs. Gregory Burkart Mr. and Mrs. Franklin J. Ellias Ms. Gayle A. Ihlenfeldt Mr. and Mrs. Victor John Manzon Dr. and Mrs. Mark I. Burnstein Dr. and Mrs. Adel A. El-Magrabi John and Ella Imerman Foundation Marketing Associates, Inc. John D. Butler and Energy Products, Inc. In-Line Construction Mr. Dean Masciulli Charlita W. Butler Fund Dr. and Mrs. Stewart Epstein Invacare Ms. Stephanie Masis Mr. and Mrs. Joseph J. Buttigieg III Ernst & Young LLP Mrs. Constance W. Jacob Ms. Brenda L. Mastrovito C. Neumann Associates, Inc. Estate of Henry J. Bourque Mr. and Mrs. David J. Jacob Mr. and Mrs. Robert Matuja Mr. and Mrs. John T. Caldwell, Jr. Estate of George & Bessie Josie Mr. and Mrs. Michael M. Jacob Max & Erma’s Calendar For A Cure Estate of Mary Berman Mr. and Mrs. Albert Jadach Mr. and Mrs. John McAlpine Mr. and Mrs. Howard Camden Farbman Group Mr. and Mrs. John P. Jagger Mrs. Mary C. McEvitt Camelot Ventures Mr. Jeremiah E. Farrell Ms. Kathleen Marie James McKesson Medical - Surgical Carl’s Golfland Mr. and Mrs. Robert Z. Feldstein Mr. and Mrs. Richard J. Janes Mc Kinley Associates, Inc. Mr. and Mrs. Thomas R. Carlson Mr. and Mrs. Michael F. Fenberg Mr. and Mrs. Hollis Jencks Mrs. Christina Balian Mehren

* Susan G. Komen Breast Cancer Foundation Detroit Race for the Cure® HOPE | SUMMER 2005 15 locally presented by the Barbara Ann Karmanos Cancer Institute. DONORS 2003 16 Ms. Norma Riehl Mr. and Mrs. Dean E. Richardson Ms. Ann Richards Richard,Craig Inc. Mr. andMrs. Lloyd E. Reuss FoundationRaymond Rankauf The Foundation Mr. Brian T. Rand Mr. andMrs. Richard Purtan Dr. andMrs. Pullman Thomas Prudential Foundation Matching Gifts Provider HealthnetServices Proto Gage The Professional Group Dr. W. Charlotte Podowski Whalers Plymouth Centers Service Plastic ProgramGifts FoundationPﬁzer Matching Mr. andMrs. Jerome Pesick Mr. John Richard Penders, II Mrs. Nora Peisner Mr. andMrs. J. Arvin Pearlman Dr. Pass Harvey Dr. andMrs. Howard Parven Mr. andMrs. Richard G. Partrich Mr. andMrs. Norman Pappas Mr. andMrs. John Palmer Mr. Edward B. Palm Mrs. Margaret G. Palacky Oxford Area Chamber of Commerce Biotech Ortho Dan Dairy Original The Club Country Orchard Lake Mr. Pat O’Neill Credit UnionOakland County Ms. Pet Nosan BrothersNorth Ford, Inc. Mr. andMrs. Nida Charles New CenterStamping, Inc. Ms. Margaret Ness Nemer Property Group, Inc. Ms. KarenNear National Precast, Inc. National Company Lumber Management National Logistics National ConeyIsland, Inc. MoveSource, Inc. Charles Stewart Mott Foundation Mr. Donald F. Morris Mr. andMrs. Morganroth Erik Mr. andMrs. Morganroth Jeﬀrey Moosejaw Mountaineering, Inc. MooreThe HonorableMarion Mr. andMrs. Roy Moore Ms. E. Phyllis Moore Mr. J.J. Modell Mr. andMrs. Dominic S. Moceri Mr. andMrs. I. Miller Matthew The HonorableJamesE. Mies Midwest HealthPlan, Inc. UAW-CAPMichigan Council Daughters ofIsabella Circle MI State MGM Mirage Voice Foundation Lynch Merrill

HOPE

| | SUMMER 2005 SUMMER

Mr. andMrs. S. Matthew Sosin Sofanou, Inc. Mr. E. Jeﬀrey Sobel Mr. andMrs. Todd Smith Mr. andMrs. Richard Sloan Ms. RheaSlavik Mr. andMrs. Frank Sklarsky Mr. G.Timothy Skillman Mr. D. Gerald Skellenger Mr. and Mrs. Michael H. Simmons Mr. andMrs. Howard F. Sims Mr. andMrs. Paul R. Silverman Mr. andMrs. Silver Robert Mr. andMrs. Mark A. Sikina Market,Shoppers Inc. Ms. Shirley Lee Virginia Shifrin-Hayworth Dr. Fayth K. Yoshimura Dr. Anthony F. and Shields Mr. andMrs. I. Sherr William Mr. andMrs. Edward Sherman Mr. andMrs. Sherman Larry Shark Tool andDie, Inc. Celebration ofHope Maynard’sShaggie Mr. andMrs. Lloyd Semple EcoShred Secure Mr. L. Gerald Scott Mr. MichaelS. Schwartz Mr. andMrs. AlanE. Schwartz Mrs. Schwartz Geraldine Mr. andMrs. AlanS. Schwartz Mr. and Mrs. Douglas A. Schubot Mr. and Mrs. Morton L. Scholnick Mr. Robert V. Schechter Mr. andMrs. Schafer Arnold Mrs. AliceM. Sattler Medical,Sanarus Inc. Barney Smith Salomon Dr. andMrs. Mark B. Saﬀer King,Safety Incorporated Mr. DennisRuss Mr. andMrs. Anthony Rusciano John andAngela Ruckdeschel Royal Oak Womens Soccer Rossetti Mr. andMrs. Rosenthal Steven Mr. andMrs. Norman Rosenfeld Family Foundation H.Bruce And RosalieN. Rosen Mr. andMrs. Rose Scott Mr. R. Robert Roman Mr. andMrs. Rochlin Morris Laboratories,Roche Inc. Mr. and Mrs. Kenneth A. Robinson Mrs. R. Barbara Robinson Ms. Robinson Laura Mr. DavidRobinson Mr. and Mrs. Seymour M. Roberts Mr. Richard L. Roberts R. L. Polk &Co. Rite-On Industries, Inc. Rissman Investment Company Mr. andMrs. Rissman Burton Mr. andMrs. Rissman Robert Mr. H. Steven Riga

Turner-Brooks, Inc. Toyota MotorSales, U.S.A., Inc. Mr. andDr. S. Sheldon Toll Consulting Group,Titan Inc. Mr. andMrs. Michael Timmis Thrivent Lutherans for Financial Sebold &AssociatesInc.Thomas Mr. andMrs. Russell W. Thomas Team Angels Foundation Mr. J. Scott Taylor Tawas Powder Coating, Inc. Tamer Foundation Consultants, Inc. AutomotiveSuburban Mrs. K. Christine Strumbos Dr. andMrs. Thomas M.Storen Mr. andMrs. A. Robert Stone FoundationStevenson Walter H. &Ella Mr. Todd A. Stevens Mr. andMrs. John A. Stevens Steelcraft Tool Company Stant Mr. andMrs. CecilM. Stallard St. John HealthSystem FundCharitable D.Arlene Spohn ProductsSpeedrack Group Ltd. Wineman FoundationWineman Mr. II Wineman Henry Eye Laser Institute Windsor Wilma Christensen Conservatorship Mr. andMrs. Willens Harvey Foundation J. andAlmenaGray Ernest Wilde Dr. andMrs. Widlansky Steven Schools District Whitehall Western Waterprooﬁng Company Mr. and Mrs. Thomas Wennerberg The Group,Wellness Inc. Mrs. Weiss Sandra Mary Mr. andMrs. J. Steve Weiss ofMedicine School Wayne - University State Community College Wayne County Mr. andMrs. Ward E. Watz Wal-Mart Foundation Wallside Windows Mrs. Lynn Walls Mr. Thomas Wade W. M. Associates, Inc. Vpsi, Inc. Mr. andMrs. Jack Vought Vitec Dr. Patricia A. Vint InternationalCorporation Victor Valentine &Associates Dr. Usher Lawrence Medicine Specialists Internal University United Paint and Chemical Corp. Human Resources UAW-GM CenterFor UAW-Daimler Chrysler UAW 845 Local Ms. Danialle Tynan

Wild GameDinner Wild NFL AlumniAssociation Detroit Chapterofthe Golf Outing Dale Meyer Memorial Foundation GameDinner Wild Constantino DelSignore Binson’s ChiliCookoﬀ B.of Stephen Campau Tournament inMemory Annual Skins’ Golf $5,000 ORMORE EVENTS RAISING 2003 THIRD PARTY Sr. Foundation W. Tom Zurschmiede, Mrs. HelenZuckerman Mr. andMrs. Zieve Morton Mr. andMrs. Paul R. Ziegler Yazaki America, North Inc. WWJ-TV/WKBD-TV The WWGroup, Inc. Mr. andMrs. George A. Wrigley WOMC (104.3FM) Mr. andMrs. David Wohleen Mr. andMrs. R. Charles Wise FoundationWinkelman Isadore &Beryl Mrs. Doreen Hermelin Party hostedbySummer by Ms. HeidiStein Holiday Party hosted FELLOWS PARTIES CIRCLE OF Detroit theCure® for Race Breast CancerFounation G.Susan Komen 8th Annual Billionaires’ Bash 7th Annual ANight ofGood Taste 21st Annual Dinner 19th Annual Detroit Roast Classic andBlack Ball Tie 10th Annual Partners Golf 2003 SIGNATURE EVENTS Women Luncheon Weight Watchers Remarkable Webasto GolfOuting Cancer Beneﬁt in Philanthropy Breast GuildSinai The Women Bowling Tournament Memorial Cruchon Steve Annual GolfClassic FoodsRoselli Inc. FundraiserMemorial ClassicRichard Farkas CancerGolf Pummill Patrick J. GolfClassic Delaney 3rd Annual GolfClassic WolfeJerry Golf Outing Memorial George Lekas Game Hockey All-star League East CoastHockey GolfOuting Purtan Dick Detroit’s Greekstock VI

D ABOVE $1 MILLION Dura Automotive Systems, Inc. Costantino Del Signore Foundation Floyd B. and Helen M. Mr. Peter Karmanos, Jr. *Dykema Gossett, PLLC Craig Richard Promotional Products, Inc. Thormann Foundation ONORS Julie and Edward C. Levy, Jr. Estate of Frances Angel David Robinson Company UAW-Ford National Programs Ctr Foundation Estate of Nancy Brown Delphi Corporation United Way Community Services $100,000 - $999,999 Estate of Margaret Eaegle Mr. and Mrs. Stephen DeSilva *UPS Estate of Mildred Fritz Ed Rinke Buick U.S. Equities Realty, L.L.C. Mr. and Mrs. Thomas V. Angott, Sr. Estate of Lillian Hammond Mr. and Mrs. Kenneth Eisenberg Mr. and Mrs. Giovanni Vitale 2004 Community Foundation for Walbridge Aldinger Company Southeastern Michigan Estate of Florence McGrath Estate of Walter and Ella Stevenson Weight Watchers Group, Inc. Estate of Allie Barnes Estate of Martha Morand *Ethan Allen Estate of Edward and Estate of Evelyn Murphy Etkin Grandchildren Philanthropic Fund $1,000 - $4,999 Estate of Doris Ressler Ida M. Faigle Charitable Foundation Henrietta Knabusch AAA Life Insurance Company Estate of Herbert Ressler Forbes Company Estate of Robert E. Valk Ms. Carmen Abrego Estate of Max M. Shaye Samuel and Jean Frankel Foundation Mr. and Mrs. Richard Purtan *A.C.C.E.S.S. Health Programs Estate of Nellie Stone General Motors Acceptance Corporation Dr. and Mrs. John C. Ruckdeschel Ms. Veda M. Acea Mr. Burton D. Farbman Mr. and Mrs. Bruce Gershenson Mr. and Mrs. Alan S. Schwartz Mr. Allan R. Adelson 2004Mr. and Mrs. David T. Fischer Gethsemane $50,000 - $99,999 Mrs. W. Kay Agney *Ford Motor Company Fund Ghafari Associates, Inc Agree Realty Corp. Anonymous Mr. and Mrs. Stanley Frankel Gordon Chevrolet, Inc. AIREA Mr. and Mrs. Joseph J. Buttigieg III Gemellaro Companies Greater Detroit Bowling Assn. *Compuware Corporation Dr. Terrance L. Albrecht and Gianni Ferrarotti Lung Cancer The Hartmann Foundation Dr. Louis A. Penner Credit Union ONE Foundation Haworth Alco Transportation Inc. Estate of Mary Lew Appleby Goodman Family Charitable Trusts The Hayman Co. Mr. and Mrs. Robert A. Allesee Estate of Frances V. Deneau Mr. and Mrs. Mark Gorenberg Mr. and Mrs. Peter Helman Amber Products Co., Inc. Estate of Dorothy Stewart Ilitch Holdings, Inc. Herman Miller Foundation Ambrose Inc. General Motors Corporation Janet L. Ripper Oncology Fund Huntington Bank American Cancer Society Mr. and Mrs. Bernard Lee Hartman *Johnson & Johnson Ms. Gayle A. Ihlenfeldt Amgen, Inc. Michigan Jewish Sports Foundation Mr. and Mrs. Nick Karmanos Mr. Doug Jablonski Ammex, Inc. Mr. John L. Ripper Ms. Joan J. Kughn Mr. and Mrs. Hank Jallos Ms. Lynn C. Anderson Women’s Committee Lear Corporation Johnson Controls, Inc. Ms. Tina Anzaldi for Hospice Care Mr. Robert Littman Mr. Mark S. Kahn APAC Paper & Packaging $25,000 - $49,999 Mrs. Judy McCarthy Mr. and Mrs. Martin Kellman Corporation Dr. and Mrs. Donald C. Austin Ford Motor Company Kicks for the Cure Mrs. Carol Pappas Appel Blue Cross Blue Shield of Michigan *Meijer The King’s Daughters and Sons, Inc. Appleton Comerica Incorporated Pummill Cancer Golf Classic Mr. Alexander Krezoski Artisan Associates, Inc. DaimlerChrysler Mr. and Mrs. Milton H. Ring *Kroger Company of Michigan ArvinMeritor, Inc. Corporation Fund R.L. Polk & Co. Lawson Software Autoliv Mr. and Mrs. Aleksandar Erdeljan Rock Financial: A Quicken Edward C. Levy Company Mr. Vernon G. Baker II Loans Company Estate of Carmel Brock *Marshall Field’s Ms. Annette Balian Mrs. Frances Rodgers Estate of Alexander Mayorchalk Masco Corporation Mr. Robert G. Barker Mrs. Janet D. Russell Mr. and Mrs. Samuel Frankel McLennan Family Foundation Mrs. Sonny Barnett School District of City of Royal Oak Mr. and Mrs. Stephen Grand *Metro Detroit Ford Dealers Ms. Sondra Bass The Sinai Guild Hand In Hand Foundation Mr. and Mrs. Ronald J. Meyer Mrs. Jean C. Baumgarten *Smith Barney Harry B. and Anna Korman Michigan UAW-CAP Council Ms. Lindsay Beard Foundation Suburban Automotive Mosher, Dolan, Cataldo & Kelly Becker Ventures Molinello Family Foundation Consultants, Inc. *National City Mr. Glen Beesley Mr. David Murphy Taubman Centers North Brothers Ford, Inc. Ms. Tracy J. Bell The Nailco Group Thrivent Financial for Lutherans Novartis Pharmaceuticals Corporation Ms. Sara Benvenuti Radiation Oncology Research and *Turner Construction Company Development Center Dr. and Mrs. Vainutis K. Vaitkevicius Mr. John Richard Penders, II Mr. and Mrs. Dennis S. Bernard Roselli Wholesale Foods Inc. Webasto Roof Systems, Inc. Pentastar Aviation, LLC Mr. Paul J. Berra Sinai Medical Staﬀ Foundation Mr. Roger Weisberg and *Pﬁzer Inc. Dr. and Mrs. John Bielawski The Steven J. Biegel Ms. Karen Freedman Mr. and Mrs. Maurice Pogoda Big Boy Franchise The Professional Group - Preferred Management LLC Golf Outing, Inc. $5,000 - $9,999 Team Angels Building & Ground Services Binson’s Home Health Care Centers Visteon Allstate Insurance, Co. The R. C. Mahon Foundation Ms. Amy Brieden Andrews Ramser-Morgan Foundation The Birchwood Farms Golf $10,000 - $24,999 & Country Club Mr. and Mrs. Eugene Applebaum Ruth F. Ratter and Ann F. & Mr. and Mrs. Randolph J. Agley *AstraZeneca Norman D. Katz Foundation Birmingham Chrysler Plymouth Jeep Eagle, Inc. AT&T Automobile Club of Michigan *RE/MAX 100 Mr. William D. Blaul, Jr. Charity Motors, Inc. Baskin Law Firm, P.C. Secure EcoShred Mr. Mitch Bleznak Mr. and Mrs. Michael Chirco BBK Seligman Family Foundation Blue Cross Blue Shield of Michigan Community Health Charities Buddy’s Rendezvous Pizzaria, Inc. Mr. and Mrs. Michael Soave Blue Ribbon Restaurants, LLC Cornish, Zack, Hill Cancer Loan Closet Soroptimist International and Associates, Inc. Foundation of Greater Detroit of Trenton Area Mr. and Mrs. Paul Borman Dana Corporation CareTech Solutions, Inc. Mr. and Mrs. Steve Stoddard Brass Craft Mfg.Co. Deloitte Touche LLP Clear!Blue Detroit, LLC Thomas Sebold & Associates Inc. Mr. and Mrs. Arthur Braverman

* Susan G. Komen Breast Cancer Foundation Detroit Race for the Cure® HOPE | SUMMER 2005 17 locally presented by the Barbara Ann Karmanos Cancer Institute. DONORS 2004 18 Mr. Greg E. Elliott Mr. andMrs. Franklin J. Ellias PreferredEducators Corporation F. andOlga Irv Dworkin DuPont Dow Elastomers Don Shula’s Hotel&GolfClub Mr. andMrs. S. William Doll Mr. J. McGregor Dodds D.O.C OpticsCorporation Direct Inc. Optical Dietech Tool &MFG., Inc. Mrs. Dienesch Katharina Diamond Holdings, LLC Ms. C. Leslie Devereaux Mr. Deutch Martin Association, Inc. Detroit Women’s Bowling Detroit Red Wings, Inc. Detroit Lions Charities Detroit oftheNAACP Branch Mr. andMrs. Derocher William Mr. andMrs. Thomas D. Demery ofMichigan Delta DentalPlan Foundation Rotary Dearborn Center,Montessori Inc. Heights Dearborn Board ofEducation Dearborn University Davenport Ms. Daniels Jeaneriann Mrs. Rita V. Dallavecchia Dakota Inn, Inc. Custom Homes by Derocher, Inc. Ms. JoAnne Croskey Cranbrook Schools Financial Federal Credit Union Cornerstone Community Mr. Conforti Louis Carmen Comedy Castle, Inc. Corporation Comcast Mrs. Avern Cohn The Honorableand Mr. andMrs. M. Charles Clute Ms. MeghanClemente Ms. Clemente Kaitlyn Mr. andMrs. JamesA. Clement Mr. John S. Cleary Dr. andMrs. Jerome V. Ciullo Banking Corporation Citizens Ceridian Cell Inc. Therapeutics Ms. Cavender Jessica Mr. D. Gerald Carney Mr. JamesH. Carnagie Carl’s Golﬂand Associates, P.C. and VascularCardiology Mr. andMrs. Howard Camden Products,Cale Medical Inc. C. Neumann Associates, Inc. Mr. andMrs. Burkart Gregory Mr. Fred A. Bunting Management Inc. Brown Rehabilitation Brown Printing Company Dr. andMrs. Brodsky Burton Commitee, Inc. Breast CancerResource

HOPE

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SUMMER 2005 SUMMER

Mrs. Hugh G. Harness Ms. Hardy Elizabeth Ms. Hammer Sarah Ms. Patricia A. Hadley Corporation Haden Schweitzer Mr. DavidH. Gutow Mr. andMrs. Torbett B. Guenther Mr. andMrs. M. Eric Gudeman Guardian Automotive Corporation Groen, &Company Kluka Greg Dawson &Associates, Inc. Mr. andMrs. Fred E. Greenspan Mrs. Freida R. Greene Greektown Casino, LLC *Great Lakes International Recycling Ms. Graves Cynthia Properties *Grand/Sakwa Ms. Angela Graham Ms. Patricia Ann Gotham Mr. Mark J. Goldman Mrs. EleanorGolden-Zuppke Mr. and Mrs. Dale Michael Goldberg Frank L. and Helen Gofrank Foundation The Goalie’s Den Ms. Debra Glendening-Karmanos Mr. Glasier Stuart Mr. andMrs. B. William Gilbert Mrs. G. Cynthia Gier Mr. and Mrs. Lawrence S. Ghannam Center Oncology Gershenson Radiation Mr. JamesL. Gerback MotorsFoundationGeneral Corp. AtlanticGeneral Service Mr. andMrs. F. Sergio Gasperoni Dr. andMrs. H. F. Gallasch, Jr. Research &Education The Fund For Medical FordFriendly Mr. Richard A. Freund Mr. Joseph N. Francis Dr. andMrs. D. Jeﬀrey Forman *Ford MotorCredit Company and Fuel Tank Plant Ford Engine Dearborn Mr. andMrs. Forbes Sidney Five Manufacturing, Lakes Inc. Mr. MaxM. Fisher Mr. J. Alfred Fisher, Jr. Mr. andMrs. Finkel Seymour Mr. andMrs. Todd Fink Mr. andMrs. MichaelF. Fenberg Mr. George Femat Mr. Jeremiah E. Farrell Mr. andMrs. Richard B. Everson Eurest DiningServices Estate of Walter H. & Ella Stevenson M.Estate ofShirley Essery Estate ofAliceBendever & Ernst Young LLP FundHigh School Ernest W. Seaholm Equibal, Inc. Dr. andMrs. Epstein Stewart Products,Energy Inc. Processing Steel Emerald EMAG L.L.C. Dr. andMrs. Adel A. El-Magrabi

Mrs. F. Elizabeth Janda Ms. James Marie Kathleen Ms. Yvonne M. Jacques Mr. andMrs. DavidJ. Jacob Mr. Thomas G.III Jackson J &AU.S.A., Inc. Foundation Winkelman Isadore &Beryl Mr. Paul Inman Ms. DeniseIlitch Mr. andMrs. Paul JamesHudzik Mr. and Mrs. Joseph L. Hudson, Jr. Hoveround Corporation and Cohn, LLP Honigman Schwartz Miller HoMedics, Inc. The Home Accessory Warehouse Mr. andMrs. BrandonHitch Hines Interest Limited Partnership Ms. M. Erika Hicks Mr. andMrs. John E. Herlitz Ms. LishaHenry FordHenry HealthSystem Ms. DawnM. Hemmen American, North Hella Inc. Ms. Brenda Heath Mr. andMrs. E. JanHartmann Mr. MilesD. Hart Mr. Harris Steven Lake Shore HighSchool Shore Lake Ms. SharonLage GrossLadies Open Dr. andMrs. Jerome Kwartowitz Mr. Kupper Steven Dr. Walter J. Kubinski Ms. Mary T. Kubica KT Sales, Inc. Mr. and Mrs. Albert L. Krimmel, Jr. Mr. Kramer Brian Fannie Foundation Kraft Mr. JamesKondoﬀ Mr. andMrs. Alison M. Kolb Mr. andMrs. Ronald P. Knezek Group,Kirschner Inc. Ketel One Vodka Kesley-Hayes Company Corp.Kenwal Steel Mr. andMrs. MichaelKenny Ms. LisaS. Kenny FoundationMemorial Keith Anthony Baker Mr. andMrs. Kaye Bruce Mrs. AliceM. Karoub Mrs. Karmanos Laura Mr. andMrs. Jason R. Karmanos Ms. JanetL. Onesian Mr. Peter and Kalil Institute Kaizen Mr. M. Melvin Kaftan Ms. Patricia Ann Jolly Ms. A. Kathline Johnson Foundation John A. L. andMarlene Boll CommunityFoundationJewish Mr. Jeﬀers Derrick J.E.A. Enterprises, L.L.C. *Jazzercise Mrs. M. Sheila Jarmon-Starkie

Ms. JanetP. MacQueen Ms. Nicole M. Lyon Mr. andMrs. A. Robert Lutz Mr. J. Edward Lundy Mr. Alphonse S. Lucarelli Mr. Andrew L. Littman Mr. R. Carlton Lindell Mr. Richard Lin Mr. andMrs. GlennLiebowitz Dr. and Mrs. Arthur S. Lieberman Ms. E. Melvy Lewis Mr. andMrs. J. Seymour Levine Mr. andMrs. Levine Gerald Dr. A. Melvin Lester Dr. andMrs. L. Barnet Leland Ms. M. Wilma LeJeune Ms. Leigh Cynthia Mr. Lefkofsky William Mr. andMrs. Lefkofsky William Products, Inc. Creative Leather Leegin Mr. John Lech Mr. andMrs. John Laws Broderick, PLC OﬃcesofMatthew Law Ms. Dorothy S. Lauderdale and Associates Latcha School Middle Larson Ms. LisaS. Lancaster Mr. andMrs. Roy Moore Ms. E. Phyllis Moore MooreThe HonorableMarion Ms. Monar Deborah Mr. andMrs. Tom Monahan Mrs. Molenda Shirley Mr. andMrs. J.J. Modell Dr. andMrs. Misra Saroj &Motley,Mills L.L.C. Mr. andMrs. Miller Martin Mrs. JoanMiller Mr. Richard Thomas Mihalovich The HonorableJamesE. Mies Anesthetists (MANA) Association*Michigan ofNurse Construction,MHB L.L.C. MGM Mirage Voice Foundation of Credit Unions Metro West Chapter Corporation Metaldyne Melco Distributing, Inc. Mrs. BalianMehren Christina NetworkMedical One Mr. DanielG. McNicholl -Surgical McKesson Medical Mr. andMrs. JamesMcGuﬃe Mrs. C. Mary McEvitt Mr. andMrs. John McAlpine Ms. S. Silvia Maxwell Max &Erma’s Mr. andMrs. Matuja Robert Ms. Masis Stephanie Industries,Marianna Inc. Mr. andMrs. Manning Mervyn Mrs. Carol E. Mann Mr. andMrs. Manery Kris Malin Corporation Dr. andMrs. Madorsky Erwin Madison Company Electric

D Moran Chevrolet Mr. and Mrs. Morris Rochlin Tammy Taylor Nails, Inc. Susan G. Komen

Ms. Myra Moreland Mr. Abner Roman Ms. Julie Taubman Breast Cancer Foundation ONORS Morgan Stanley Mr. George Scott Romney Thomas J. Walsh Appraisals Detroit Race for the Cure® Ms. Christina Morgan and Mrs. Ellen Rogers Titan Consulting Group, Inc. Circle of Fellows Party Mr. and Mrs. Jeffrey Morganroth Bruce H. And Rosalie N. Rosen Title Source, Inc. Hosted by Mr. Joseph Zada Family Foundation Ms. Sheila Mott *Todays Staffing 2004 THIRD PARTY Mr. and Mrs. Norman Rosenfeld MoveSource, Inc. Mr. and Dr. Sheldon S. Toll EVENTS RAISING 2004 Mr. Kevin Murphy Rossetti Ms. Nancy A. Tourville MORE THAN $5,000 Royal Oak Dental Towers Perrin Nail Tek Binson’s Chili Cook-off Mr. Christopher A. Nash Ms. Carolyn Rudolph Trinity Episcopal Church Brighton Collectibles Bracelet Sale National Coney Island, Inc. Mr. and Mrs. Anthony Rusciano Mr. Eric E. Trott Buddy’s Pizzeria - “Got Pizza? The Ryzman Foundation Mr. and Mrs. James Tutorow National Hockey League Give Dough!” National Logistics Management Dr. and Mrs. Mark B. Saffer Ms. Danialle Tynan The Salvation Army Constantino Del Signore National Lumber Company UAW-Aerospace-Agriculture Ford Foundation Wildgame Dinner Ms. Karen Near Mr. Edward Samulski Local No. 182 Mr. Richard Sanchez CRS Pig Roast Ms. Kimberly A. Nehra UAW-GM Center For Sanders Building Services, Inc. Dale Meyer Memorial Golf Event *New Balance Human Resources Ferrarotti Lung Cancer Farmington Hills and Troy Ms. Brenda A. Sanders Ukrainian Future Credit Union Walk and Rally New Center Stamping, Inc. Mrs. Karen E. Sarris Ukrainian Selfreliance Michigan Ms. Bernadette Savard Ms. Linda Petro Ulrey Fisher and Company Holiday Party Mr. and Mrs. Charles Nida Hand-in-Hand Foundation (UAW SBC Unique Edge 2000, Inc. Nordstrom and DaimlerChrysler Corporation) Mrs. Deborah A. Norris SBC Michigan Updata Capital, Inc. Mr. and Mrs. Robert R. Scherba Hank Greenberg Memorial Northwood TPA, Inc. Dr. Lawrence Usher Golf and Tennis Tournament Mr. and Mrs. Morton L. Scholnick Nosan Building Corporation Dr. and Mr. Manuel Valdivieso, MD. Ms. Patricia A. Schuh-Harris George Lekas Memorial Golf Outing Ms. Christina Nowicki Variations Salon Mr. Michael S. Schwartz Golf to Beat Cancer - Staub Financial Oakland County Credit Union Victor International Corporation Mr. Gerald L. Scott Janice S. McTigue Oakland Hills Cardiology Victor Properties, Inc. Ms. Karen Seaver Memorial Golf Outing The Original Dairy Dan Dr. Patricia A. Vint Mr. and Mrs. Lloyd A. Semple Kicks for a Cure - Giving You A Ortho Biotech Mrs. Kristen von Bernthal Fighting Chance to Beat Cancer Mr. and Mrs. I. William Sherr Ms. Lisa M. Ottaviano Mr. and Mrs. Jack Vought Dr. Anthony F. Shields and Nailco Tiffany Awards Ms. Martha Ann Ottolini W. Tom Zurschmiede, Sr. Foundation featuring DREAMS Dr. Fayth K. Yoshimura Wachovia Foundation Matching Mr. and Mrs. David K. Page Ms. Laurice N. Shippings National Arab-American Gifts Program Medical Association (NAAMA) Mr. David M. Palmer Siemens Building Technologies *Panera Bread Ms. Debra T. Walker Walk for Women’s Cancers Mr. and Mrs. Robert Silver Mrs. Tometta A. Walker-Houston Parker P.T.O Mr. and Mrs. Gilbert B. Silverman 96.3 WDVD Mr. and Mrs. Richard G. Partrich Wal-Mart Foundation “Call 2 Care Radio-a-thon” Mr. and Mrs. Paul R. Silverman Mr. and Mrs. Gary L. Wasserman Dr. and Mrs. Howard Parven Ms. Richelle Simmons North Bros. Ford and The City of Penske Corporation Mr. and Mrs. Ward Earl Watz Westland 5K Fun Run and Walk Ms. Sarah Simonian Mr. and Mrs. Kenneth L. Way Mr. Roger S. Penske Ms. Karen E. Simpson Oakland Hills Country Club’s Mr. and Mrs. Jerome Pesick *Wayne State University Mulligan Stew Cookbook in Mr. Thomas A. Sinelli Dr. Herb Weisenthal memory of Scottie Colucci PHNS Sisters Network, Inc. Mr. and Mrs. Steve J. Weiss Orawave Pink Ribbon Toothbrush Plunkett & Cooney, P.C. Mrs. Libby Sklar Ms. Amanda Whitington P.E.B. Memorial Golf Scramble PMA Consultants LLC Mr. and Mrs. Frank Sklarsky *Whole Foods Patrick J. Delaney Dr. Charlotte W. Podowski Mr. and Mrs. Richard Sloan Dr. Richard Pollard Wholesale Salon Memorial Golf Classic *SoBe Furniture.Com, Corporation Dr. and Mrs. Nelson J. Pont Prelude and Revelation - Speedrack Products Group Ltd. Mr. and Mrs. Harvey Willens Ms. Talina Porter A Celebration of Martha Morand Mr. Dave Spencer Wilma Christensen Conservatorship Poseidon Industries, Inc. Pummill Cancer Golf Classic SPX Corporation Windsor Laser Eye Institute PricewaterhouseCoopers, LLP Roselli Foods Annual Golf Classic Mr. Thomas Spybrook Mr. and Mrs. Charles R. Wise *Prince Pasta Ryder Cup Captain’s Challenge St. Nicholas Greek Orthodox Church Mr. Marvin Wolf *Propel Fitness Water 7th Annual Dick Purtan Mr. Benny Stamper WOMC (104.3 FM) Mr. Gary Radka Golf Classic Standard Federal Bank Worthington Industries,Inc. Raymond Foundation Stant Manufacturing, Inc. Skins’ Golf Tournament, in Mr. and Mrs. Terry J. Woychowski memory of Stephen B. Campau Mr. and Mrs. Lloyd E. Reuss Star Nail Productions, Inc. X-Ray Industries, Inc. Soroptimist International Mr. and Mrs. Dean E. Richardson Staub Financial Services, Inc. Ms. Rebecca Young of Trenton Area, “Riding for Richmond Rotary Club Steelcraft Tool Company Ms. Jan Zak Breast Cancer Research” Ms. Norma Riehl Corliss Stephens *Zeta Phi Beta Steve Cruchon Memorial Mr. Lee Rink Sterling Group Limited Mr. and Mrs. Morton Zieve Bowling Tournament Mr. and Mrs. Burton Rissman Mr. and Mrs. John A. Stevens Mrs. Helen Zuckerman Steven J. Biegel Golf Outing Mr. and Mrs. Robert Rissman Mr. Carl Stieler 2004 SIGNATURE EVENTS Team Angel Fighting Mr. Richard L. Roberts Mr. and Mrs. Robert A. Stone Breast Cancer with a Mr. Anthony Robinson Dr. and Mrs. Thomas M. Storen 11th Annual Partners Passion for Fashion Ms. Fradreaka L. Robinson Strategic Employee Benefit Services Golf Classic and Black Tie Ball The Janet Lynn Ripper Ms. Lisa A. Robinson The Stricof Family Foundation 20th Annual Detroit Roast Medical Oncology Fund Roche Laboratories, Inc. Ms. Helen Suchy 22nd Annual Dinner Golf Outing Rochester Fraternal Order Mr. and Mrs. Patrick Suman 7th Annual A Night of Good Taste United Way’s Ticket of Eagles Auxiliary #2634 Tamer Foundation 8th Annual Billionaires’ Bash to Ride Promotion

*Susan G. Komen Breast Cancer Foundation Detroit Race for the Cure® HOPE | SUMMER 2005 19 locally presented by the Barbara Ann Karmanos Cancer Institute. WAYS OF GIVING 2004 LEGACY SOCIETY

The Karmanos Cancer Institute offers many ways for donors to support The Legacy Society recognizes individuals who have generously established an estate or planned gift to benefit the Barbara Ann the Institute while meeting their personal financial goals. A representative Karmanos Cancer Institute. Estate and planned giving provides from the Institute’s Development Office will be happy to discuss giving vital support cancer research and treatment programs. options with prospective donors. Prospective donors are encouraged to These gifts are regarded as the ultimate endorsement consult a financial advisor when considering a gift. For more information of our commom cause in the battle against cancer. about giving call (313) 576-8150 or visit www.karmanos.org. Mrs. Jan L. Adler-Jacobs Mr. & Mrs. Robert Allesee CASH GIFTS Mr. & Mrs. Joseph Antonini Cash gifts are the most common type of gift. Usually in the form of a check, Dr. & Mrs. Donald Austin the gifts may be given in one lump sum or spread out over three to five years. Ms. Imogene Banks Gifts of cash may be deducted from taxable income in the year they are made Miss. Tamrya Blassingame when the donor itemizes deductions. The donor’s tax rate and other factors will Dr. & Mrs. Michael Brennan determine the amount of tax savings. Ms. Ellen Brown Mr. W. Donald Christian PLEDGES Mr. Steven Daugherty Mr. Michael Deighan Multi-year pledges are an ideal way for donors to provide significant support Mr. & Mrs. Dennis Dermidoff for the Institute. Payments are typically stretched over five years and donors Mr. Samuel Deyo agree to a set schedule of giving. Reminder notices are sent at regular intervals. Ms. Nina Drolias GIFTS OF STOCKS AND BONDS Mr. Irving & Mrs. Olga F. Dworkin Ms. Diane-Jo Ferschnuder Outright gifts of appreciated stocks, bonds or mutual funds provide sub- Mr. & Mrs. Gerald Fournier stantial tax advantages to donors. When these appreciated assets are given Ms. Margaret Friedman directly to Karmanos Cancer Institute, donors are free of the capital gains Ms. Susan Greenstein tax. Donors also may claim a tax deduction equal to the fair market value of Ms. Andrea Grennan the securities on the date of delivery. Mr. & Mrs. Richard Hall To make a gift of appreciated securities, donors should notify their broker Mr. & Mrs. E. Jan Hartmann or banker of their intent. The broker should then notify the Institute’s Ms. Elizabeth Leone Heaton Development Office directly for direction on transferring the assets. Mr. and Mrs. Keith Hobson Securities may also be sent directly with endorsement, please include a Dr. & Mrs. Larry Howell signed stock power for each certificate. Ms. Robin King Kedzo Mr. Robert Klein, Esq. Gifts of depreciated securities are also welcome, but the procedure differs. Ms. Lucy Klotz Donors should sell the stocks or other securities to realize the capital loss. Ms. Janice Kovac Proceeds may then be given to the Institute. Ms. Helen Lake GIFTS OF REAL ESTATE Mr. & Mrs. Craig Lehmann Mr. & Mrs. Joseph Letourneau Donors may make a gift of their residence, farm or vacation home while Ms. Rebecca Matoff reserving the right of occupancy for their lifetime and that of their spouse. Mr. David Murphy An irrevocable gift of real estate qualifies for an immediate tax deduction on Ms. Phyllis Rembowski the present value of remainder interest. Ms. Joanne Rickle Mr. Gerald Rompel MATCHING GIFTS John C. Ruckdeschel, M.D. Participation in a corporate matching gift program is an excellent way to Ms. Linda Samelson multiply a contribution to the Karmanos Cancer Institute. Numerous Mr. Thomas Saull companies recognize their employees’ charitable gifts by matching or often Ms. Estelle Schafer doubling these donations. Submit your company’s matching gift form to the Ms. Margaret Seifferlein Development Office along with your pledge card or payment. Ms. Marilyn Snodgrass Ms. Kathleen Springman DEFERRED GIFTS Ms. Gertrude Schwarz Ms. Judith Tinor Various opportunities exist to contribute to the Institute through deferred Dr. & Mrs. Vainutis Vaitkevicius giving. A representative from the Institute’s Development Office will be Mr. Stanley Wiktor happy to discuss this gift category with interested donors. Mr. Gerald Wittkop Mr. & Mrs. Paul Witzke

20 HOPE | SUMMER 2005 UP CLOSE

MANUEL VALDIVIESO, M.D.

TITLE: Chief Medical Officer and Medical Oncologist at Karmanos Cancer Institute EDUCATION: M.D., San Fernando Medical School, San Marcos University, Lima, Peru MEDICAL TRAINING: Cook County Hospital, Chicago, Illinois M.D. Anderson Cancer Center, Houston, Texas PERSONAL: Married with five children INTERESTS: Classical music GREATEST PROFESSIONAL Dr. Valdivieso has two ment where ACCOMPLISHMENT: “The most physicians, important thing to me is to have been primary interests: classical music and nurses and part of developing the team approach medicine. While the similarities aren’t immediately obvious, support staff to treating lung cancer at both Karmanos he sees parallels between bringing talented musicians are really Cancer Institute and at the M.D. Anderson together in a symphony hall and uniting cancer experts Cancer Center” on a multidisciplinary team. committed to this high level [BIO] “The only way to truly hear an orchestra is to bring all the of teamwork musicians together and listen to them play as opposed to in favor of the having them play scattered throughout the city,” he said. cancer patient while always looking for novel treatments Similarly, he believes the best way to treat cancer is to bring and approaches in the care of our patients.” a wide variety of cancer experts together to discuss each Dr.Valdivieso’s passion for medicine started when he was a patient’s case and collectively recommend the best course of boy in Peru. Growing up in what he described as “humble treatment for each patient. circumstances,” the tailor’s son was always fascinated with The Karmanos Cancer Institute provides multidisciplinary science. That strong curiosity, coupled with a desire to help patient care through 14 teams of cancer specialists, each people, drew him to medicine. focusing on specific forms of cancer, all supported by an extensive research program. The teams are staffed by experts “I was fascinated with the biological process of disease,” he in all areas of cancer treatment (surgery, medical oncology said. And then his interest turned deeply personal when his and radiation oncology) and support services including father passed away after a battle with stomach cancer. pathology, radiology, internal medical specialties, data The loss of his father was one of many experiences that helped management, clinical trials, nursing and social work. shape Dr. Valdivieso’s philosophy of patient care. He said he As part of his many responsibilities as Chief Medical Officer, has learned much over many years of treating very sick people. Dr. Valdivieso oversees all 14 multidisciplinary teams. “Patient anxiety and suffering has made me a better listener He also serves on the Thoracic/Lung multidisciplinary team and I’ve become more able to explain the illness in clear, and the Institute’s Phase I Clinical Pharmacology Program. understandable terms. I help them put it into perspective,” he “It’s the right way to treat patients with malignancies,” Valdivieso said. “Patients have also taught me to be more compassionate. said. In fact, it’s a primary reason why he returned to Karmanos I relate better to my patients. I’m more spiritual now and from a position in Illinois. “I wanted to be part of an environ- understand better just how fragile life is.”

HOPE | SUMMER 2005 21 NEWS AND NOTES Age-Specific Mortality Rate and Excess Deaths

3,500 60 – 74:

KARMANOS AND WAYNE STATE UNIVERSITY 2,922 882 Excess Deaths 3,000 (Rate Difference: + 948, 48% Higher)

AWARDED $2.5 MILLION GRANT 50 – 59: 2,500 734 Excess Deaths (Rate Difference: + 719, 122% Higher) 1,974 Older African-Americans in Detroit have a dramatically 2,000 higher rate of death from cancer than white Detroiters of 1,616 Excess Deaths 1,500 1,306 the same age. That’s one of the reasons the Karmanos X 10 Years (1990-2000): Rate (per 100,000) Cancer Institute and Wayne State University’s Institute 1,000 Over 16,000 Deaths 587 of Gerontology recently received a $2.5 million grant from 500 This accounts for over one-third the National Cancer Institute (NCI) to study cancer of the loss in senior population 0 disparities among minority populations. 50 - 59 60 - 74 in Detroit from 1990 to 2000 Age Group

Detroit Population: United States Census (2000) The Institute is a natural choice for this type of study. It Mortality: Michigan Department of Community Health, Public Use Files (1999-2001) Remainder of Michigan operates an NCI-designated comprehensive cancer center – one of only 39 in the United States – and it serves one of ELDERLY AFRICAN-AMERICANS the nation’s largest African-American populations. IN DETROIT HAVE SIGNIFICANTLY HIGHER MORTALITY RATES WHEN According to U.S. Census data, there is a large rate of COMPARED TO THE REST OF THE diﬀerence between Detroit’s senior population and those STATE OF MICHIGAN. THE STUDY seniors in the rest of Michigan when it comes to hospitaliza- WILL LOOK AT WAYS TO LESSEN tion and mortality rates. For people between the ages of 50 and THE GAP. 59, Detroiters have a 122 percent higher mortality rate than those seniors in the rest of Michigan. Those between the ages of 60 and 74 have a 48 percent increase in mortality rates. Behavioral Oncology Program, is serving as the principal The NCI grant will establish the Community Networks investigator of the study and TERRANCE ALBRECHT, PH.D. Program (CNP), an initiative that will create lasting partner- director of the Community ships among community leaders, researchers and medical Network Program. Albrecht, professionals to assist in education, research and training along with her co-investigator, aimed at reducing cancer disparities in older African- Peter Lichtenberg, Ph.D., ABPP, Americans. The CNP will facilitate community-based director, Institute of Gerontology, will be working on research and training projects to promote early detection, identifying community groups and organizations that can treatment seeking and routine surveillance. assist with this important eﬀort. They will also develop Terrance Albrecht, Ph.D., director of Behavioral and Field education programs and collateral materials to distribute to Research and leader of the Institute’s Communication and the older African-American population in Detroit. Community Network Program Partnerships

The Barbara Ann Karmanos Cancer Institute and Wayne State University’s Institute of Gerontology (IOG) are proud to partner with the following local and national organizations, as part of their commitment to eliminate health disparities in elderly African-Americans. The Institute and the IOG would like to thank the following organizations for their efforts in helping secure the NCI grant. If you know of an organization that would like to become a part of the CNP, please contact Lisa Berry-Bobovski at (313) 966-2766.

RESEARCH/TRAINING PARTNERSHIPS Cancer Control Division, Michigan Michigan Society of Karanos Cancer Institute (KCI) Department of Community Health Hematology/Oncology Michigan Center for African-American Catholic Archdiocese of Detroit Pﬁzer Aging Research (MCUAAAR) City of Detroit Senior Citizens Department Sisters Network, Inc., Wayne State University (WSU) Detroit Area Agency for Aging Detroit Chapter Institute of Gerontology (IOG) Detroit Area Parish Nurses Association WSU Center for Urban and Faith Access to Community Economic CLINICAL PARTNERSHIPS African-American Health (CUAAH) Development (FACED) University Family Physicians Clinic Fox 2 Detroit - WJBK Detroit City Health Clinics COMMUNITY PARTNERSHIPS Hannan Foundation Wayne County Department of Aging Service Consortium of Detroit IOG Healthy Black Elders Center Public Health American Cancer Society – KCI Community Advisory Committee Voices of Detroit Initiative Great Lakes Division Michigan Cancer Consortium BCCCP Program

22 HOPE | SUMMER 2005 KARMANOS RESEARCHER KARMANOS LEADER PUBLISHED IN JAMA APPOINTED TO NCI BOARD

The Journal of the American Medical Beth Golden, R.N., BSN, director of the Association ( JAMA) recently published Institute’s Clinical Trials Office has been a study by Ann G. Schwartz, Ph.D., MPH, appointed to the National Cancer Institute’s associate center director of population Central Institutional Review Board (CIRB). sciences, at Karmanos Cancer Institute “I feel privileged to be a member (of and Michele Cote, Ph.D., assistant this board) in one of the few positions professor, at the Karmanos Cancer open to oncology nurses,” said Golden. Institute. Dr. Schwartz also serves as ANN G. SCHWARTZ, PH.D., MPH Created in 2000, the CIRB was established director of the Metropolitan Detroit to develop an innovative approach to human Cancer Surveillance System and professor subject protection in national, multi-center of Internal Medicine at the Wayne State trials while simultaneously reducing the University School of Medicine. administrative burden on local Institutional The study investigates the risk of lung Review Boards (IRBs) and investigators. cancer among Caucasian and African- Its 15 to 20 members include oncology American relatives of individuals with professionals, oncology nurses, ethicists and early-onset lung cancer. The article was patient advocates from diverse organizations published in the June 23 issue of JAMA. throughout the country. NCI seeks CIRB members who are qualified through INSTITUTE NAMES expertise, experience and diversity to ensure NEW VICE PRESIDENT its ability to safeguard the rights and welfare DEBRA HERRING, R.N., MBA of human research participants. Debra Herring, R.N., MBA, recently joined RESEARCHER FEATURED IN the Karmanos Cancer Institute as vice presi- SCIENTIFIC JOURNAL dent of clinics. Herring is now overseeing the Karmanos Cancer Center’s clinical operations, Avraham Raz, Ph.D., director of the including the Day Treatment facility at the Tumor Progression and Metastasis Lab at Wertz Clinical Cancer Center, as well as the the Karmanos Cancer Institute, feature in a Gershenson Radiation Oncology Center and recent edition of the research journal Cancer the Walt Comprehensive Breast Center – all Biology & Therapy. Dr. Raz’s photo is on the located in midtown Detroit – and the Weisberg cover of the respected journal. He is the latest Cancer Treatment Center in Farmington Hills. in a series of prominent scientists and clinicians invited to write about their careers and BETH GOLDEN, R.N., BSN Herring has extensive leadership experience experiences. Dr. Raz’s story is featured in the in outpatient oncology services, having served June 2005 Cancer Biology & Therapy article, as director of Ambulatory Care Services at “Sugar Recognition and Metastasis: From Northwestern Memorial Hospital in Chicago Birth of a Research Field to the Clinic.” and as director of Clinical Operations for the Moffitt Clinic of the H. Lee Moffitt Cancer In 2003, Dr. Raz was honored with the Center in Tampa, Florida. Metastasis Research Society’s Paget-Ewing Award, recognizing 25 years of excellence The Ohio native earned a Bachelor of in metastasis research. At the time, the Science degree in health arts from the Bloomfield Hills resident said, “Cancer University of St. Francis in Joliet, Illinois research is my passion and I am pleased and a Master of Business Administration to be part of an organization right here in from Dominican University in River Forest. Metro Detroit that’s committed to doing AVRAHM RAZ, PH.D. Her new home is in Grosse Pointe. what it takes to eradicate cancer.”

HOPE | SUMMER 2005 23 AROUND town PATIENT GIFT BASKETS

Lauren Miller, along with her parents Lynn and Jack, helped spread sunshine among patients at the Karmanos Cancer Center. In December 2004, Lauren’s pastor at the Kensington Community Church in Troy challenged his congregation to make a diﬀerence in the lives of others. With only $100 in seed money, volunteers were instructed to demonstrate how someone can make a diﬀerence relying on their natural talents and limited resources.

Lauren chose to organize Indoor Marketplace, a shopping boutique showcasing a variety of vendors selling everything from jewelry to Tupperware. With help from other volunteers, Lauren raised more than $2,500 for the Karmanos Cancer Center. The Miller family has been touched by cancer, and Lauren knew she could make a real diﬀerence by brightening a cancer patient’s day. Using prudent shopping and gift donations, Lauren created 70 treat-ﬁlled baskets and passed them out to Cancer Center patients. Joined by her parents, Lauren greet each patient with a warm smile, a thoughtful gift and a caring spirit.

WHISPERS OF HOPE

Marisa Selva and Joanne Santi of the San Marino Ladies Auxiliary in Troy hosted “Whispers of Hope”, a dinner and fashion show in memory of Anna Marie Alexander, sister of Joanne Santi. The April event beneﬁted the Gail Purtan Ovarian Cancer Fund at the Karmanos Cancer Institute. Jackie Purtan emceed “Whispers of Hope”, which honored her parents, Dick and Gail Purtan.

LEFT TO RIGHT: MARISA SELVA, JACKIE PURTAN, DICK PURTAN, JOANNE SANTI AND GAIL PURTAN.

FRIENDS RAISING FUNDS The Karmanos Cancer Institute’s Friends Raising Funds program provides support to individuals, community organizations and businesses that seek ways to get involved with the Institute or Cancer Center. From golf outings and walks to bake sales and private dinners, hosting your own event oﬀers a great way to help fellow patients, survivors and families undergoing the uneasy times of a cancer diagnosis or treatment. Through hundreds of events, the Friends Raising Funds program raises more than $400,000 each year. AROUND town KICKS FOR THE CURE

The WDIV TV-4 team: Beth McLeod, Eric Wilson, Rhonda Walker and Guy Gordon take a shot at Omar Akl of Omar’s Planet, the world’s ﬁrst Internet gym. In March, Omar and the Channel 4 crew teamed up for the 2nd Annual Kicks for the Cure kickboxing class held at the Power House Gym in Farmington Hills. The event was a tremendous success as more than 30 kickboxing enthusiasts suited up to help raise funds to kick cancer. Since 2003, Kicks for the Cure has raised about $15,000 to beneﬁt the Karmanos Cancer Institute.

GFLCF GOLF OUTING

Carted up and geared for the green! Over 140 golfers took to the Moose Ridge Golf Course in South Lyon for the First Annual Gianni Ferrarotti Lung Cancer Foundation (GFLCF) Golf Outing. The GFLCF began after Gianni Ferrarotti, a dear husband, father and friend, lost his battle with lung cancer. The Ferrarotti family founded the GFLCF to educate and support families with loved ones undergoing lung cancer treatment. The Foundation’s ultimate goal is to one day bring an end to the disease. Since 2004, the GFLCF has raised more than $30,000 to support lung cancer research at the Karmanos Cancer Institute.

For more information on how you can get involved in an Institute or Cancer Center fundraising event contact Maureen Bender at 313-576-8111 or [email protected]. 12TH ANNUAL UPCOMING EVENTS Partners Golf Classic 09 PROSTATE CANCER Summer in Michigan means golf. And for the Partners – a group of AWARENESS MONTH young professionals in Metro Detroit united in the fight against cancer – it Don’t delay ... make an means raising money for the Barbara Ann Karmanos Cancer Institute. appointment for your The 12th Annual Partners Golf Classic will be held on September 12, 2005 annual check-up today! at the Orchard Lake Country Club in Orchard Lake, Michigan. Tee times ...... are at 7:30 a.m. and 1 p.m., but space is limited. This competitive scramble is one of Michigan’s finest golf outings, attracting 09.12 Southeast Michigan’s top business and community leaders. Guests will join PARTNERS fellow cancer fighters to enjoy a day of golf, food, beverages and prizes. GOLF OUTING Through the Golf Classic and the annual Partners Ball, the Partners Join us for the Partners 12th have raised more than $4 million for the Karmanos Cancer Institute Annual Golf Classic at Orchard over the past 11 years. Lake Golf and Country Club. For more information, contact Denise Lowe at ...... (313) 576-8110 or via email at [email protected]. 09.17 PARTNERS SUMMER BALL Dance the night away at the General Motors Technical Center’s Vehicle Engineering Center in Warren.

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4100 John R Detroit, MI 48201 www.karmanos.org