The Palgrave Handbook of the History of Surgery
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Philibert Joseph Roux (1780–1854)
SURGEONS Philibert Joseph Roux (1780–1854) He´le`ne Perdicoyianni-Pale´ologou Summary: Philibert Joseph Roux (1780–1854), a French surgeon, was a student and friend of Marie Xavier Franc¸ois Bichat, the father of modern pathology and histology. He was assigned as a surgeon to the Hoˆpital Beaujon (1806), the Hoˆpital de la Charite´ (1810) and to Hoˆtel-Dieu de Paris (1835), where he succeeded to Guillaume Dupuyrten, a French anatomist, as a Chief Surgeon. Roux is best known for having performed the surgical repair of a cleft palate and for having been the first surgeon to stitch a ruptured female perineum. His contribution to surgery has also included the publication of Quarante anne´es de pratique chirurgicale. Roux was awarded the grade of Chevalier of the National Order of the legion of Honor and that of Officer. He also served as a President of the Academy of Sciences. He died of a stroke on 3 March 1854. Philibert Joseph Roux was born on 26 April 1780 at Medical studies Auxerre, a commune in the Bourgogne region in north-central France. His father, Jacques Roux, At the suggestion of his father he continued his a Surgeon-in-Chief first at the Hoˆtel-Dieu1 in Paris and medical studies in Paris. He presented himself at the later at E´ cole Militaire in Auxerre, treated him with Concours d’Entre´e to the Val-de-Graˆce7 but failed com- great harshness and severity in response to his idleness prehensively. He then decided to study at the E´ cole de and intemperance. -
Dear Colleagues, As the Directors of the Bloomington Drosophila Stock
Dear colleagues, As the directors of the Bloomington Drosophila Stock Center, the national repository for strains of Drosophila melanogaster, we appreciate this opportunity to comment on the proposed redistribution of NCRR Division of Comparative Medicine activities to other NIH entities. In particular, we would like to address the plans to place oversight of non-primate model organism resources within NIGMS. Although we regret the loss of an NIH institute dedicated to research resources, we support the "straw model” plan to relocate the program for non-primate animal models from NCRR to NIGMS. NIGMS is the logical home for this essential activity, because both NIGMS and model organism resource centers support the full breadth of biomedical research—from investigations of fundamental biological processes to disease treatments. Because NCATS will focus primarily on advancing the development of new therapeutics, its mission will not encompass many resource center activities and it should not be expected to evaluate and oversee them. The resource centers strongly promote translational research and the development and use of animal models of human disease, but support of basic research is, and should continue to be, a central part of their mission. Translational research is possible only because a strong foundation of fundamental biological knowledge has been developed through basic research. It is appropriate that the administrative structure of NIH reflects this reality with respect to the oversight of non-primate model organism resources. There are strong synergisms between research supported by NIGMS and the interests of model organism research communities. As the primary funder of basic biomedical research in the U.S., NIGMS has steadfastly supported investigation in fields that underpin translational research such as biochemistry, molecular biology, genetics, developmental biology, physiology, pharmacology, neurobiology and behavior. -
Use of a Single Hybrid Imaging Agent for Integration of Target Validation with in Vivo and Ex Vivo Imaging of Mouse Tumor Lesions Resembling Human DCIS
Use of a Single Hybrid Imaging Agent for Integration of Target Validation with In Vivo and Ex Vivo Imaging of Mouse Tumor Lesions Resembling Human DCIS The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Buckle, Tessa, Joeri Kuil, Nynke S. van den Berg, Anton Bunschoten, Hildo J. Lamb, Hushan Yuan, Lee Josephson, Jos Jonkers, Alexander D. Borowsky, and Fijs W. B. van Leeuwen. 2013. Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS. PLoS ONE 8(1): e48324. Published Version doi:10.1371/journal.pone.0048324 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:10859968 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Use of a Single Hybrid Imaging Agent for Integration of Target Validation with In Vivo and Ex Vivo Imaging of Mouse Tumor Lesions Resembling Human DCIS Tessa Buckle1,2, Joeri Kuil1,2, Nynke S. van den Berg1,2, Anton Bunschoten1,2, Hildo J. Lamb3, Hushan Yuan4, Lee Josephson4, Jos Jonkers5, Alexander D. Borowsky6, Fijs W. B. van Leeuwen1,2* 1 Department of Radiology, Interventional Molecular Imaging Laboratory, Leiden University Medical Center, Leiden, The Netherlands, 2 Departments of Radiology and Nuclear Medicine, Netherlands Cancer -
Research – the Institute for Comparative Medicine
Prospectus – Vet Graduate School The Institute for Comparative Medicine This new Institute has been established as the research division of the School, and to promote an integrated approach to research strategy and planning. The Institute has a strong and diverse research profile much of which is directed towards the fundamental problems common to Veterinary and Medical diseases. Research within the Institute of Comparative Medicine is organised into four themes (Infection and Immunity, Wellcome Centre for Molecular Parasitology, Comparative Pathobiology, Animal Health). These four research themes encompass nine focussed sections that represent the major research activity of the Institute. Resources • Well equipped laboratories • Library • Study areas • PC & On-line access Research Groups Infection and Immunity (Contact: Prof. Andy Tait; [email protected]) Molecular and Immunobiology of Parasitism (Contact Prof. E. Devaney; [email protected]) The research of this group, which includes the Wellcome Centre for Molecular Parasitology (contact Prof. D.Barry; [email protected]), focuses on nematodes and protozoa, and involves molecular and immunological approaches to the understanding of their biology, immune evasion and pathogenesis. The fundamental knowledge which flows from these studies is being applied in the development of novel chemotherapeutics and vaccines. Research on nematodes uses C.elegans as a model system to investigate the development of the cuticle and to analyse the functional roles of key parasite-derived molecules. This research is directed at both the functional analysis of factors determining the expression of environmentally and developmentally regulated genes, as well as parasite regulation of the host immune response. -
Severe Burns in World War II
Ulster Med J 2017;86(2):114-118 Medical History Severe Burns in World War II. John Hedley-Whyte, Debra R. Milamed Accepted: 16th October 2016 Provenance: externally peer-reviewed. INTRODUCTION Flight Lieutenant Dickson, the plane’s commander was also badly burned and losing blood from head wounds, but The Ulster Auxiliary Air Force Squadron RAF 502 were Sergeant O’Connell was even more severely burned. Dickson former “weekend flyers”. Officers and most of the air and collapsed and cows licked O’Connell’s wounds3,4,5. ground crew were from Ulster1. Supported by their medical and surgical care and their leadership they contributed decisively to Allied victory in World War II . At 3:15 AM on 27th April 1941, Pilot Officer Christopher Carmichael of 502 Squadron took Whitley aircraft Z6501 to roll out on Limavady’s partially completed airfield. A crew of 6, including Pilot Officer Christopher Carmichael, Flight Lieutenant John Dickson, Sergeant Desmond “Des” O’Connell, Sergeant Stanley William Dorney, Sergeant Fred Redhead, Sergeant John Wilson (Air Gunner) were scheduled for a ten-hour anti U-boat patrol over the Atlantic. Shortly after take-off, the starboard propeller broke off. The Whitley hit Loughermore Mountain being unable to gain altitude or fly level on one engine. Fire broke out and ignited aviation gasoline and the 250 pound bombs2,3 (Fig.1). Fig 2. Sir Archibald McIndoe (1900-1960), by Edward Irvine Halliday, painted 1962-63, oil on canvas 92 x 72 cm, courtesy of Hunterian Museum at the Royal College of Surgeons of England Fig 1. Two Whitley Bombers Airborne, by Robert T. -
Burns and Frostbite in the Red Army During World War II Vladimir Sokolov, Alexey Biryukov*, Igor Chmyrev, Mikhail Tarasenko and Pavel Kabanov
Sokolov et al. Military Medical Research (2017) 4:5 DOI 10.1186/s40779-017-0114-9 PERSPECTIVE Open Access Burns and frostbite in the Red Army during World War II Vladimir Sokolov, Alexey Biryukov*, Igor Chmyrev, Mikhail Tarasenko and Pavel Kabanov Abstract The start of World War II (WWII) led to the deployment of combat troops in several continents. Destruction and many casualties among both the military and civilians became an inevitable consequence. A large amount of people injured were in need of life-saving treatment and a speedy return to duty. Intensive studies of the specific issues of diagnosis and treatment of thermal injury were conducted in the Soviet Union before the war. The first special units for patients with burn injuries were created, and the first specialists received their first clinical experience. The contributions of famous Soviet scientists in the development of the treatment of burns and frostbite in WWII are studied in this article. The structure of thermal injuries among military personnel and the results of their treatment are shown. Treatment, classification and quantity frostbite in the structure of sanitary losses during the WWII are studied in this article. Keywords: Thermal injury, World War II, Statistics of burns and frostbite, Specialized burn centers Treatment of patients with burns prior to the It is impossible not to note that historically unprece- WWII dented innovations - intravenous infusion systems and, The Soviet Union, its allies and its opponents had no in particular, blood transfusion systems- first appeared specialized medical units for patients with burn injur- in the 1920s. These procedures were used as a means ies in military or civilian hospitals when the WWII of treatment for burns. -
COMPARATIVE MEDICINE and VETERINARY SCIENCE APRIL Published Monthly at GARDENVALE, QUE
Canadian Journal of COMPARATIVE MEDICINE AND VETERINARY SCIENCE APRIL Published Monthly at GARDENVALE, QUE. by NATIONAL BUSINESS PUBLICATIONS, LIMITED EDITORIAL BOARD T. W. M. CAMERON,. T.D.; M.A.; B.Sc. (Vet. Sc.); Ph.D.; D.Sc.; M.R.C.V.S. Director, Institute of Paravitology, Macdonald College, Que. Chas. A. MITCHELL, V.S. B.V.Sc.; D.V.M. Pathologist, Animal Diseases Research Institute, Hull, Que. R. A. McINTOSH, M.D.V.; B.V.Sc. Professor, Diseases of Animals, Obstetrics, Therapeutics, Ontario Veterinary College, Guelph, Ontario. G. T. LABELLE, D.M.V. Inspecteur Vetirinaire senior, Montreal, P. Q. Subscriptions $2.00 per year to qualified veterinarians, libraries, and scientific institutions. Volume 7 Number 4 CONTENTS IDr. A. F. Cameroii, V. 0. G., Retires ....... .............. 97 Dr. E. A. WVatson Retires ......... ................... 98 Obituary-Dr. G. C. Lawrelnce ........ .................. 99 Eiizootic Bovine Haematuria ............ ................ 101 Veterinary Problems from Feeding Coniditions ..... ....... 108 Chastek Paralysis on Alberta Fox Ranbch ...... ............ 112 Implied Warranty of Fitness-Legal Decisioni ..... ....... 114 Current Veteriniary Literature ........ .................. 118 Western Ontario Veterinary Associafioli ........ .......... 123 Book Reviews ..................... ..................... 124 IPUBUAIN IMIbITED ADVERTISING OFFICES:-Head Office:-Gardenvale, Que. Telephone: Ste. Anne de Bellevue 700. Montreal Office:-M. G. Christie, Castle Bldg. Telephone Ma. 9534. Toronto Office:-137 Wellington St., Room 1206, (V. E. Heron). Telephone: Waverley 6206. Vancouver:-F. A. Dun- lop, P. Q. Box 582. Telephone Pacific 2527. New York; W. G. Gould, 7 West 44th Street. Tele- phone, Murray Hill 2-9888 Chicago:-William S. Akin. Suite 512, Mercantile Exchange Bldg., 308 West Washington Street, Telephone: State 8496. San Francisco:- C. H. Woolley, Room 708, 605 Market Street. -
Sir Archibald Mcindoe Sir Archibald Mcindoe
Published online: 2019-08-26 Icon of this issue Icon of this issue: Sir Archibald McIndoe Sir Archibald McIndoe ir Archibald McIndoe, the pioneer of post burn between him and Sir Harold Gillies who happened to reconstruction and one of the four towering British be a cousin of his that he became involved in plastic Splastic surgeons of the World War II era, was born surgery and went into partnership and practice with in New Zealand in 1900. the latter. At the onset of the war it was clear to McIndoe that burns treatment techniques at that time Along with Sir Harold Gillies, Rainsford Mowlem and were inadequate involving the use of tannic acid and T Pomfret Kilner, Sir Archibald McIndoe was given tannic jelly which when applied to the tissue, dried charge of one of the four “cottage hospitals” during the and tightened the latter and thereby reduced fluid World War II. This was the Queen Victoria Hospital at loss. This tightening of the tissues however resulted East Grinstead where the author spent five years of his in severe burn contractures. McIndoe devised new residency in the UK. techniques in the treatment of burns including the use of his famous saline burn bath. He pioneered the use He attended Medical school in his native New Zealand of flap construction to rebuild the facial features and before being invited to the Mayo Clinic for further hands of Airmen who had been burned during the air studies. He initially took up a position as a First Assistant battles of World War II. -
The Queen Victoria Hospital Collection
The Queen Victoria Hospital Collection The Queen Victoria Hospital Collection at East Grinstead Museum explores the Hospital's unique heritage. McIndoe and his Guinea Pigs The Queen Victoria Hospital, which stands on the Holtye Road, East Grinstead started life as a cottage hospital in 1863 and achieved fame during World War II due to the success it had in treating the War's burnt airmen. Plastic surgeon Archibald McIndoe, a charismatic New Zealander, was charged with custody of this task and arrived there in early September 1939, treating his first patient from the War in December. McIndoe proved to be a pioneering surgeon in the treatment and reconstruction of burns, having been schooled by his distant relative and the then authority on burns treatment Harold Gillies. Whilst at the Hospital McIndoe developed a number of surgical procedures. He succeeded in having tannic acid which, although used for the treatment of burns, actually caused more harm than good, banned, and pioneered use of the saline bath after noticing that airmen who ditched in the sea fared better than those that crashed onto land. Plastic surgery was, then, in its infancy and, prior to the growth in understanding of burns treatment that developed during the War, most people that experienced burns to the level that his patients did would not previously have survived. It was McIndoe's insistence that his patients be treated holistically and that their psychological readjustment to life was just as important as that of their medical complaints, that he became renowned for. McIndoe encouraged his patients to go out into the town of East Grinstead, he had a barrel of beer installed on the ward and would often join his patients at the piano he also installed there to help boost moral. -
GSA Response to NIH Request for Information On
Genetics Society of America Response to NIH Request for Information FY 2016-2020 Strategic Plan for the Office of Research Infrastructure Programs: Division of Comparative Medicine and Division of Construction and Instruments Programs Request for Information (NOT-OD-15-056) • Response Form Submitted March 16, 2015 Responses are limited to 1,500 characters per topic. All responses must be submitted by March 16, 2015. Disease Models, Informational Resources, and Other Resources Disease models, informational resources and other resources that should be modified or expanded in parallel with ongoing advances in biomedical research The Genetics Society of America (GSA) emphasizes the importance of model organisms for advancing knowledge in biomedical research. We believe that continued investment in model organisms—and the resources needed for supporting this research—is one of the most effective and efficient ways for NIH to continue to advance our understanding of living systems and improvement in human health. Model organism researchers depend upon shared community resources that serve the entire community, including stock centers and model organism databases, several of which depend upon ORIP funding. The long-term and consistent support of these community resources has been a crucial component of the strength and success of biomedical research in the United States and assures its future vigor. Centralized stock centers and databases provide optimal resource sharing that maximizes the return on the investments made by NIH and other government agencies. These community resources provide “off-the-shelf” research tools and thus increase the efficiency and speed of hypothesis-driven research supported by other grants. In addition, NIH support for these community resources allows them to operate on an open access model, thus assuring that all researchers have the tools they need for discovery. -
Baron Guillaume Dupuytren (1777-1835): One of the Most Outstanding Surgeons of 19Th Century
239 19 Hellenic Journal of Surgery 2011; 83: 5 Baron Guillaume Dupuytren (1777-1835): One of the Most Outstanding Surgeons of 19th Century Editorial G. Androutsos, M. Karamanou, A. Kostakis Received 17/06/2011 Accepted 21/07/2011 Abstract 200,000 francs and also collections so that a museum Baron Guillaume Dupuytren is considered to be a of pathological anatomy could be established at the leading figure of surgery. Domineering and unfor- Faculty of medicine, the museum which today bears giving to those who were an obstacle in his career, his name. He also made an important bequest that he was unrivalled as a teacher and respected as an the faculty create a chair of pathological anatomy excellent surgeon. Regarded as the greatest surgeon for his friend and disciple Cruveilhier. of the 19th century, he introduced the anatomo-clin- ical method in surgery. Key words: Dupuytren, Eminent surgeon, Dupuytren’s disease, Anatomo- clinic method Life-studies Guillaume Dupuytren was born in the village of Pierre-Bouffière, the son of a constantly struggling lawyer (Fig.1). His eventful life began at the age of three when he was kidnapped by a lady who thought him charming and whisked him off in her carriage. At seven, he ran away from home, but was soon brought back and punished. Shortly afterward, a troop of hussars came along, fell under his spell and, surprisingly, got permission to take him with them to Paris. He studied Humanities at the Magnac-La- val College, then at the Marche in Paris (1789). At Fig. 1 The eminent surgeon Guillaume Dupuytren (1778-1835) the end of his studies (1793), he wanted to become a soldier. -
Yale Medicine Magazine
Short-term gains, long-term losses Winter 2020 ALSO 4 FDA approval for Ebola vaccine / 44 Paying it back: Kristina Brown’s quest / 46 The machinery of immune systems Features 12/ Inflammation: part hero, part villain The traditional approach to inflammation is that it’s bad and should be suppressed, but recent findings offer a more nuanced view. By Christopher Hoffman 18/ Studying autoimmunity Researchers hope that the Colton Center for Autoimmunity at Yale will yield results over the next 10 years. By John Curtis 20/ Ketostasis: nature’s sweet spot Glucose plays a complex role in immune system health. By Sonya Collins 24/ Another use for aspirin A versatile remedy also a potential treatment for breast cancer. By John Curtis 26/ Untangling the web of autoimmune disorders When a person develops certain autoimmune disorders, others often follow in their wake. Figuring out why, and how to stop the deterioration, are top priorities for scientists. By Steve Hamm 30/ Why most heads don’t swell Some places in the body don’t suffer from inflammation as a response to intrusion. The brain and spinal cord are among them. By Christopher Hoffman 34/ A new dimension to intestinal surgery One doesn’t often think of the intestines when thinking about how 3D printing can assist with surgery or medicine. John Geibel is looking to change that. By Adrian Bonenberger 36/ Exploring the frontiers of immunity and healing Researchers at Yale are aware of how wounds know to heal. Now they want to know why. By Katherine L. Kraines OTTO STEININGER ILLUSTRATIONS STEININGER OTTO : AGE winter 2020 departments COVER AND OPPOSITE P 2 From the editor / 3 Dialogue / 4 Chronicle / 9 Round Up / 40 Capsule / 42 Faces / 46 Q&A / 48 Books / 49 End Note winter 2020 from the editor volume 54, number 2 Yale’s Actions and Response to Coronavirus (COVID-19) website, covid.yale.edu, provides such information as clinical and laboratory research, patient care, resources to both track Editor the spread of the virus and help cope during this crisis, COVID-19 news, and messages.