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Mouse Anti-Tex19.1 Monoclonal Antibody, Clone 8UFY-2G22 (CABT-RM122) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

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Mouse Anti-Tex19.1 Monoclonal Antibody, Clone 8UFY-2G22 (CABT-RM122) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use Mouse Anti-Tex19.1 monoclonal antibody, clone 8UFY-2G22 (CABT-RM122) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Specificity Detects murine Testis-expressed protein 19.1 (Tex 19). Target Tex19.1 Immunogen His-tagged full-length recombinant mouse Testis-expressed protein 19.1 (Tex 19). Isotype IgG2b, κ Source/Host Mouse Species Reactivity Mouse Clone 8UFY-2G22 Purification Protein G purified Conjugate unconjugated Applications ELISA, ICC, IHC, IP, WB Molecular Weight 40.40 kDa calculated. Format Liquid Size 100 μg, 25 μg Buffer 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl Preservative 0.05% sodium azide Storage Stable for 1 year at 2-8°C from date of receipt. Warnings Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. BACKGROUND 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Introduction Testis-expressed protein 19.1 is encoded by the Tex19.1 gene in murine species. Tex19.1 resides in the germline to repress transposable genetic elements and maintain genomic stability. It is expressed in testis, placenta, ovary, and in pluripotent stem cells. In testis its expression is highest in mitotic spermatogonia and decreases as spermatocytes progress through meiosis. Tex19.1 expression is reported to be down-regulated by Deleted in azoospermia-like (DAZL) protein, which binds to 3'UTR of Tex19.1 mRNAs and repress its translation. Tex19.1 is required during spermatogenesis and placenta development where it participates in the repression of retrotransposable elements and prevents their mobilization. Tex19.1, along with its paralog, Tex19.2, is shown to collaborate with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Embryos with mutations in Tex19.1 gene exhibit intra-uterine growth retardation and have small placentas due to a reduction in the number of spongiotrophoblast, glycogen trophoblast and sinusoidal trophoblast giant cells. Loss of Tex19.1 is shown to cause growth defect and early post-natal lethality. Male animals with deficiency of both Tex19.1 and Tex19.2 display impaired spermatogenesis, small testes, and are infertility. Keywords TEX19; testis expressed 19; testis-expressed sequence 19 protein; FLJ35767; mTex19.1; Tex19a GENE INFORMATION Entrez Gene ID 73679 UniProt ID Q99MV2 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.
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