CANCER RESEARCH UK MANCHESTER INSTITUTE The University of Manchester Wilmslow Road Manchester M20 4BX T 0161 446 3156 F 0161 446 3109 www.cruk.manchester.ac.uk PARTICULARS OF APPOINTMENT Ref: MI/14/31 Job Title: Post‐doctoral position to develop models of prostate cancer with Richard Marais: Molecular Oncology Group 1. The Institute invites applications for the above post. 2. Salary will be within the range £28,500– £38,000 according to relevant experience and qualifications. 3. Informal enquiries can be made to Professor Richard Marais, via email: ([email protected]) 4. Applications should be returned by 2 May 2014 to the Human Resources Department, either via email ([email protected]) or to the postal address below: Julie Jarratt Recruitment Coordinator Human Resources Department Cancer Research UK Manchester Institute The University of Manchester Wilmslow Road Manchester M20 4BX Tel: (00 44) 0161 446 3231 Fax: (00 44) 0161 918 7134 5. To apply for this position please provide a completed CV cover sheet which includes the names and contact details of three referees, CV and Equal Opportunities Form. A cover letter is optional. No further information will be taken into consideration as part of your application. 6. All applicants should complete an equal opportunities form with their application. 7. If you have not been contacted within four weeks of the closing date you should assume that, on this occasion, your application has not been successful. We would, however, like to take this opportunity to thank you for your interest in the Cancer Research UK Manchester Institute, and we hope that this will not deter you from applying for other positions in the future. 8. The Institute will endeavour to contact shortlisted candidates promptly; however there may be occasions where a high volume of applications are received therefore applicant’s patience is appreciated. MI/14/31 Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK COPY OF THE ADVERTISEMENT The University will actively foster a culture of inclusion and diversity and will seek to achieve true equality of opportunity for all members of its community. Prostate Cancer UK/Movember funded Post‐doctoral position to develop models of prostate cancer. ‐ Richard Marais: Molecular Oncology Group Job Ref: MI/14/31 Salary range £28,500 – £38,000 depending on qualifications and experience. Three year duration The CRUK Manchester Institute (www.cruk.manchester.ac.uk) in the UK is a centre for excellence in cancer research. We occupy state‐of‐the‐art laboratories and provide exceptional core facilities, including next generation sequencing, mass‐spectrometry, advanced imaging, bioinformatics, histology, and flow cytometry. We are core‐funded by Cancer Research UK (www.cancerresearchuk.org), the world’s largest cancer organisation, are an Institute of The University of Manchester (www.manchester.ac.uk), and are juxtaposed to The Christie NHS Foundation Trust (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes in a vibrant and dynamic city surrounded by beautiful countryside and with excellent national and international transport links. Together with Queen’s University Belfast, we have recently been awarded a Movember Centre of Excellence for prostate cancer research. Three positions are therefore available for post‐doctoral scientists to join the Molecular Oncology Group led by Prof Richard Marais, Director of the Institute, and in the Clinical and Experimental Pharmacology Group led by Professor Caroline Dive, Deputy Director of the Institute. Prof Marais has made important contributions to our understanding of the biology and genetics of melanoma (Cell 140: 209, 2010; Cancer Cell 15: 294, 2009 and 19, 2011: 45; Cancer Research 70: 8036, 2010, NEJM 366: 207‐215, 2012; Genome Research 22: 196‐207, 2012). Prof Dive’s laboratory has an international reputation for circulating biomarker research notably relating to the utility of circulating tumour cells in personalised medicine (J Clinical Oncology 29:1556, 2011, J Clinical Oncology 30: 525, 2012, J Thoracic Oncology 7, 306, 2012, J Investigative Dermatology 133: 1582 2013, Nature Reviews Clinical Oncology 15: 30 2014). The successful candidate will join a team who will implement personalised medicine for prostate cancer. The post holder will develop in vitro and in vivo models of prostate cancer and perform functional analysis and assessment of therapeutic potential of promising leads from genomics/proteomics studies. The successful candidate will hold a PhD in cell biology, biochemistry or in vivo models and relevant experience in cancer will be an advantage. The post‐holder will be line‐managed by Prof Marais. Informal enquiries can be directed to Professor Richard Marais ([email protected]) To apply for this position please complete an equal opportunities form and submit along with a CV and accompanying CV cover sheet detailing the names of three referees to [email protected] quoting the job reference number above. For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email: [email protected] to have this information sent by post. The deadline for receipt of applications is 2 May 2014 and first round interviews will take place during mid‐May. Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK CANCER RESEARCH UK MANCHESTER INSTITUTE JOB DESCRIPTION JOB DETAILS: Job Title: Postdoctoral Scientist Department: Molecular Oncology Group Division: Cancer Research UK Manchester Institute (CRUK MI) ORGANISATIONAL ARRANGEMENTS: Accountable to: 1. Group Leader Molecular Oncology Group; Director JOB PURPOSE: To contribute to the success of a research programme by undertaking specific research project(s) on behalf of and guided by the Group Leader. PROJECT: A Movember Centre of Excellence for prostate cancer funded three‐year position to develop in vivo and in vitro models of prostate cancer leading to therapeutic discoveries for patient benefit. The post holder will conduct research into the role and relevance of therapeutic potential through performing functional analysis from genomic/proteomic studies. It is recognised that the post holder is in training to develop their academic independence. DUTIES AND RESPONSIBILITIES: To be inquisitive. To develop and drive an independent project within a multidisciplinary group. To pursue a program of work agreed with the Group Leader. To develop personalised/precision medicine for prostate cancer patients. To ensure successful completion of the project and maximise publication output. To prepare manuscripts for publication; to address referees comments. To keep up with the scientific literature. Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK To design and execute experiments. To use established procedures and develop new approaches; to acquire new skills. To maintain accurate records of experiments and reagents. To meet the objectives of the Movember Centre of Excellence To interact with other groups within the Movember Centre of Excellence To prepare and present work at and attend weekly laboratory meetings. To present work at the Institute, and at domestic and international meetings. To attend the Institute retreat, space permitting. To supervise graduate students, visiting scientists and others as necessary. To interact with collaborators and companies. To conform to COSHH, Codes of Practice, and Local and Institutional Rules. To perform other functions consistent with the position, nature of the post and as determined by the Group Leader. STANDARDS OF PERFORMANCE: Work efficiently, cost‐effectively and in a flexible manner To meet objectives within pre‐determined timescales Effective communications to be maintained with staff at all levels Strict adherence to protocols, Institute policies and Health & Safety instructions Familiarise themselves with the University’s Equality and Diversity policies and to actively support these wherever possible. Be a team player. To strive to accomplish high quality of work. Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK PERSON SPECIFICATION The person specification should set out the qualifications, experience, skills, knowledge, personal competencies and other requirements which the post holder requires to perform the job to a satisfactory level. Job Title: Postdoctoral Scientist ESSENTIAL DESIRABLE METHOD OF The qualities without which a post holder Extra qualities which can be used to choose ASSESSMENT could not be appointed between candidates who meet all the essential criteria PhD* in cell biology, CV and biochemistry, or a relevant field Presentation of certificate *(as a minimum requirement QUALIFICATIONS candidates must have submitted their thesis** by the start date of their employment and awarded their PhD within the specified probationary period). Experience in biochemistry, Demonstrated ability to Referees molecular biology, genetics, generate top quality comments proteomics