Journal of the American Medical Informatics Association, 26(5), 2019, 462–478 doi: 10.1093/jamia/ocy185 Review Review Comparison of blockchain platforms: a systematic review and healthcare examples Tsung-Ting Kuo,1 Hugo Zavaleta Rojas,2 and Lucila Ohno-Machado1,3 1UCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California, USA, 2Department of Mathematics, East Los Angeles College, Monterey Park, California, USA, and 3Division of Health Services Research & Development, VA San Diego Healthcare System, La Jolla, California, USA Corresponding Author: Lucila Ohno-Machado, MD, PhD, UCSD Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California, USA (
[email protected]). Received 16 June 2018; Revised 2 December 2018; Editorial Decision 11 December 2018; Accepted 7 January 2019 ABSTRACT Objectives: To introduce healthcare or biomedical blockchain applications and their underlying blockchain plat- forms, compare popular blockchain platforms using a systematic review method, and provide a reference for selection of a suitable blockchain platform given requirements and technical features that are common in healthcare and biomedical research applications. Target audience: Healthcare or clinical informatics researchers and software engineers who would like to learn about the important technical features of different blockchain platforms to design and implement blockchain- based health informatics applications. Scope: Covered topics include (1) a brief introduction