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Biographical Sketch BIOGRAPHICAL SKETCH NAME POSITION TITLE Attila Losonczy Assistant Professor eRA COMMONS USER NAME (credential, e.g., agency login) ALOSONCZY EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) University Medical School of Pécs, Hungary M.D. 09/93-09/99 General Medicine Semmelweis University, Budapest, Hungary Ph.D. 10/99-10/04 Neurobiology LSU Medical Center, New Orleans, LA, USA Postdoc. 08/03-07/06 Neurophysiology Yale School of Medicine, New Haven, CT, USA Postdoc. 08/06-04/07 Neurophysiology HHMI Janelia Farm Research Campus, Ashburn, VA, Postdoc. 05/07-10/09 Neurophysiology USA A. Personal Statement The goal of my research program is to promote our understanding of elementary molecular/cellular and circuit mechanisms of complex cognitive memory behaviors. My research focuses on the rodent hippocampus, because here this degree of understanding appears to be within reach. Here, my ongoing work aims to dissect the role excitatory, inhibitory and neuromodulatory circuits in episodic memory formation and spatial navigation. I also aim to promote our understanding of how cell type-specific network dynamics is altered under pathological conditions in animal models of neurological and neuropsychiatric disorders, such as of epilepsy and schizophrenia. To address these questions, we combine large-scale subcellular-resolution functional imaging with electrophysiological, and cell-type specific manipulations in vivo and in vitro. I have established successful collaborations with molecular neurobiologists (R. Hen, J. Gogos, F. Polleux, B. Zemelman), physicists (A. Vaziri) theoretical and computational neuroscientists (L. Abbott, J. Lisman) and hippocampal cellular and systems neuroscientists (I. Soltesz, G. Buzsaki) to develop and implement experimental tools and theoretical frameworks for mechanistic investigations into hippocampal cognitive memory functions under normal and pathological conditions. B. Positions and Honors Positions and Employment 09/95-09/99 Undergraduate Research Assistant, Department of Anatomy, University Medical School of Pécs, Hungary, (Prof. G. Lazar) 10/99-03/00 Graduate student, Department of Pharmacology, Univ. Med. School of Pécs, Hungary, (Prof. L. Seress) 04/00-07/00 Visiting student, MRC Anatomical Neuropharmacology Unit, Oxford, UK, (Prof. P. Somogyi) 08/00- 07/03 Graduate student, Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine of the Hungarian Academy of Sciences, Hungary (Prof. Z. Nusser) 08/03-07/06 Postdoctoral Fellow, Neuroscience Center, LSU Medical Center, New Orleans, LA, USA, (Prof. J.C. Magee) 08/06-04/07 Postdoctoral Fellow, Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA, (Prof. G. Miesenbock) 05/07-10/09 Research Specialist, HHMI Janelia Farm Research Campus, Ashburn, VA, USA, (Prof. J.C. Magee) 1 11/09 - present Assistant Professor, Department of Neuroscience, Columbia University, New York, NY, USA 00-07/0004/00-07/ 04/00-07/00 Honors and Awards 2001 BIF Graduate Student Scholarship – Boehringer Ingelheim Foundation 2010 Member – Kavli Institute for Brain Science, Columbia University 2011 Searle Scholar – Searle Kinship Foundation 2012 HFSP Program Grant – Human Frontiers Science 2012 Harvey L. Karp Discovery Award 2013 Young Investigator Award – NARSAD 2013 Memory and Cognitive Disorders Award – McKnight Foundation 2014 Brain Initiative Award Reviewer for Journals and Funds Science, Cell, Nature Neuroscience, Nature Reviews Neuroscience, Neuron, Nature Communications, The Journal of Neuroscience, Journal of Physiology, European Journal of Neuroscience, Hippocampus, Cerebral Cortex, IEEE Transactions on Neural Networks and Learning Systems, Journal of the Royal Society Interface NIH Molecular and Cellular Substrates of Complex Brain Disorders Special Emphasis Panel ZRG1 MDCN- P(57), European Research Council (ERC), The Wellcome Trust (UK), Royal Society (UK), Human Brain Project (EU), Swiss Science Foundation, The Hungarian Scientific Research Fund, Hungarian Brain Project, Human Frontiers Science Program (HFSP) Invited Speaker/Departmental Seminar 2015 Harvard Center for Brain Science 2015 Centre de Recherche Université Laval Robert-Giffard, Canada – invited by Lisa Topolnik 2014 GABAergic Signaling in Health and Disease, Washington DC 2014 Max Planck Florida Institute, Jupiter, Florida – invited by David Fitzpatrick 2014 Center for Biomedical Neuroscience, San Antonio, Texas – Neurology Ground Round 2014 Department of Neurobiology, Harvard Medical School – invited by Christopher Harvey 2014 Freiburg University, Germany – invited by Marlene Bartos 2014 Institute of Science and Technology, Vienna, Austria – invited by Peter Jonas 2014 Gordon Research Conferences – Synaptic transmission, Waterville Valley, New Hampshire 2014 FENS – In vivo functional recording of neuronal population activity, Milan, Italy 2014 Conference Jacques Monod – Optical imaging of brain structure and function on multiple spacial scales, Roscoff, France – invited by Angus Silver 2014 Department of Neuroscience, Yale University, New Haven – invited by Michael Higley 2014 NIH/NIGMS, Bethesda – invited by Chris McBain 2014 Epilepsy Research Center Symposium, Irvine – invited by Ivan Soltesz 2014 IBRO Workshop, Debrecen, Hungary 2013 Institute of Experimental Medicine, Budapest, Hungary – invited by Tamas Freund 2013 Friedrich Miescher Institute, Basel, Switzerland – invited by Pico Caroni 2013 Gordon Research Conferences – Inhibition in the CNS, Les Diablerets, Switzerland 2013 Gordon Research Conferences – Dendrites, Les Diablerets, Switzerland 2013 Picower Institute, MIT, Boston – invited by Susumu Tonegawa 2012 HHMI Janelia Farm Conference – Neuron types in the hippocampal formation 2012 Department of Neurobiology, New York University, New York – invited by Gord Fishell 2012 Albert Einstein College of Medicine, Department of Neuroscience – invited by Pablo Castillo 2012 HHMI Janelia Farm Conference – Dendrites, substrates for information processing 2011 IBRO/FENS Conference, Ljubljana 2011 Department of Physiology, Columbia University, New York – invited by Wes Gruber 2008 Department of Neuroscience, Yale, New Haven 2008 Picower Institute, MIT, Boston 2006 Department of Anatomy, UC Irvine 2005 Southern Photonics Conference, Atlanta 2 C. Peer-reviewed Publications 1) Turi, G.F., Wittmann, G., Lechan, M.R., and Losonczy A. Ambient GABA modulates septo-hippocampal inhibitory terminals via presynaptic GABAb receptors. Neuropharmacology, 2015 (online) 2) Kaifosh, P. and Losonczy, A (2014) The inside track: privileged neural communication through axon- carrying dendrites. Neuron, 83:1231-1234 3) Piant S, Specht A, Zemelman B, Losonczy A, and Bolze, F. (2014) Two-photon sensitive photolabile protecting groups: From molecular engineering to nanostructuration. Biomedical Optics, doi.org/10.1364/BIOMED.2014.BT3A. 4) Kaifosh, P., Zaremba, J., Danielson, N., and Losonczy, A. (2014) SIMA: Python software for analysis of dynamic fluorescence imaging data. Frontiers in Neuroinformatics, 8:80. doi:10.3389/fninf.2014.00080. 5) Denny, C.A., Kheirbek, M.A., Alba, E.L., Tanaka, K.F., Brachman, R.A., Laughman, K.B., Tomm, N.K., Turi, G.F., Losonczy, A., and Hen, R. (2014). Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron, 83:189-201., PMID: 24991962 6) Lee, S-H., Marchionni, I., Bezaire, M., Varga, C., Danielson, N., Lovett-Barron, M., Losonczy, A., and Soltesz, I. (2014). Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron, 82:1129-1144, PMID: 24836505 8) Lovett-Barron, M., Kaifosh, P., Kheirbek, M.A., Danielson, N., Zaremba, J.D., Reardon, T.R., Turi, F.G., Hen, R., Zemelman, B.V., and Losonczy, A. (2014). Dendritic inhibition in the hippocampus supports fear learning. Science, 21, 857-63., PMID: 24558155 9) Lovett-Barron, M., Losonczy, A. (2014). Behavioral consequences of GABAergic neuronal diversity. Current Opinion in Neurobiology, 26, 27-33., PMID: 24650501 10) Kaifosh, P., Lovett-Barron, M., Turi, G., Reardon., T.T., and Losonczy, A. (2013). Septo-hippocampal GABAergic signaling across multiple modalities in awake mouse. Nature Neuroscience, 16, 1182- 1184., PMID: 23912949 11) Lovett-Barron, M., and Losonczy, A. (2013). Circuits supporting the grid. Nature Neuroscience, 16, 255-257., PMCID: PMC23434976 12) Royer, S., Zemelman, B.V., Losonczy, A., Kim, J., Chance, F., Magee, J.C., and Buzsáki, G., (2012). Control of timing, rate and firing patterns of hippocampal place cells by dendritic and perisomatic inhibition. Nature Neuroscience, 15, 769-775., PMCID: PMC22446878 13) Lovett-Barron, M., Turi, G.F., Kaifosh, P., Lee, P.H., Bolze, F., Sun X-H., Nicoud J-F., Zemelman, B.V., Sternson, S.M., and Losonczy, A. (2012) Regulation of neuronal input output transformation by tunable dendritic inhibition. Nature Neuroscience, 15, 423-430., PMCID: PMC22246433 Oren, I., and Kullmann, D. (2012) New and Views, Nature Neuroscience, 15, 344-345. Cover illustration 14) Bolze, F., Nicoud J.F., Bourgogne, C., Gug, S., Sun, X.H., Goeldner, M., Specht, A., Donato, L.. Warther, D., Turi, G.F., and Losonczy, A. (2012). Two-photon uncaging: the chemist point of view. Optical Materials, 34, 1664-1669. 15) Losonczy, A., Zemelman, B.V., Vaziri, A. and Magee, J.C. (2010) Network mechanisms of theta related neuronal
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