The FOXM1/BRIP1 Axis in Replicative Stress Induced DNA Damage Response in Neuroblastoma
Ghent University, Faculty of Medicine and Health Sciences The FOXM1/BRIP1 axis in replicative stress induced DNA damage response in neuroblastoma: functional exploration and zebrafish modeling This thesis is submitted as fulfillment of the requirements for the degree of Doctor in Health Sciences by Suzanne Vanhauwaert, 2017 Promoter: Prof. dr. Frank Speleman Co-promoter: Prof. dr. Katleen De Preter I II Thesis submitted to fulfill the requirements for the degree of Doctor of Health Sciences Promoter Prof. dr. Frank Speleman Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Co-promoter Prof. dr. Katleen De Preter Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Members of the examination committee Shizhen Zhu MD, PhD Mayo Clinic, 200 First St. SW Rochester, MN 55905 Rochester, Minnesota, USA Anna Sablina, PhD VIB-KU Leuven Center for Cancer Biology O&N 4, Leuven, Belgium Kathleen Claes, PhD Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Tom Van Maerken, MD, PhD Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Steven Goossens, PhD Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Joni Van der Meulen, PhD Department of Pediatrics and Medical Genetics, Ghent University, Ghent, Belgium Statement of confidentiality: The information in this document is confidential to the person to whom it is addressed and should not be disclosed to any other person. It may not be reproduced in whole, or in part, nor may any of the information contained therein be disclosed without the prior consent of the author. The research described here was conducted at the Center for Medical Genetics (Ghent University, Ghent, Belgium) and Dana Farber Cancer Institute (Harvard Medical School, Boston, USA) and funded by grants from the Research Foundation Flanders (FWO), the Flemish League against Cancer (VLK) and Villa Joep.
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