DOCSLIB.ORG

Speech Repetition and Theta Burst Stimulation

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Speech Repetition and Theta Burst Stimulation Neuropsychologia 50 (2012) 2026–2031 Contents lists available at SciVerse ScienceDirect Neuropsychologia journal homepage: www.elsevier.com/locate/neuropsychologia Facilitation of speech repetition accuracy by theta burst stimulation of the left posterior inferior frontal gyrus Julia Restle a,b,1, Takenobu Murakami a,1, Ulf Ziemann a,n a Motor Cortex Group, Department of Neurology, Goethe University, Schleusenweg 2-16, Frankfurt am Main D-60528, Germany b Department of Physical Education, Gutenberg University, Saarstrasse 21, Mainz D-55122, Germany article info abstract Article history: The posterior part of the inferior frontal gyrus (pIFG) in the left hemisphere is thought to form part of Received 29 December 2011 the putative human mirror neuron system and is assigned a key role in mapping sensory perception Received in revised form onto motor action. Accordingly, the pIFG is involved in motor imitation of the observed actions of 3 April 2012 others but it is not known to what extent speech repetition of auditory-presented sentences is also a Accepted 1 May 2012 function of the pIFG. Here we applied fMRI-guided facilitating intermittent theta burst transcranial Available online 11 May 2012 magnetic stimulation (iTBS), or depressant continuous TBS (cTBS), or intermediate TBS (imTBS) over the Keywords: left pIFG of healthy subjects and compared speech repetition accuracy of foreign Japanese sentences Speech repetition before and after TBS. We found that repetition accuracy improved after iTBS and, to a lesser extent, after Sensorimotor integration of speech imTBS, but remained unchanged after cTBS. In a control experiment, iTBS was applied over the left Mirror neuron system middle occipital gyrus (MOG), a region not involved in sensorimotor processing of auditory-presented Dorsal auditory stream Transcranial magnetic stimulation speech. Repetition accuracy remained unchanged after iTBS of MOG. We argue that the stimulation Posterior inferior frontal gyrus type and stimulation site specific facilitating effect of iTBS over left pIFG on speech repetition accuracy Human indicates a causal role of the human left-hemispheric pIFG in the translation of phonological perception to motor articulatory output for repetition of speech. This effect may prove useful in rehabilitation strategies that combine repetitive speech training with iTBS of the left pIFG in speech disorders, such as aphasia after cerebral stroke. & 2012 Elsevier Ltd. All rights reserved. 1. Introduction matter of debate, area F5 of the macaque brain is thought to be partially homologous to pIFG in the human brain (Petrides & Acquisition of language skills in humans involves social interac- Pandya, 1994; Petrides, Tomaiuolo, Yeterian, & Pandya, 2012). This tions in earliest infancy, and speech repetition plays a fundamental proposition is supported by several neurophysiological and neuroi- role by mapping auditory and sensory input onto matching motor maging studies, which provided evidence for the existence of a output (Hickok & Poeppel, 2004, 2007; Wernicke, 1874). At the level putative mirror neuron system in the human pIFG (Fadiga, Craighero, of neuronal networks in the brain, speech repetition occurs within & D’Ausilio, 2009; Fadiga, Craighero, & Olivier, 2005; Rizzolatti & the auditory dorsal stream, which is constituted by a temporo- Craighero, 2004). parieto-frontal network including the posterior inferior frontal gyrus Transcranial magnetic stimulation (TMS) represents a useful tool (pIFG) (Hickok, Houde, & Rong, 2011; Hickok & Poeppel, 2004, for investigating the mechanisms of sensorimotor integration in the 2007). It has been hypothesized that, in the frontal areas, so called human brain. One technique of investigation is single or paired mirror neurons contribute to this network (Corballis, 2010; pulseTMSoftheprimarymotorcortex (M1) during observing or Rizzolatti & Arbib, 1998). Mirror neurons have first been character- listening to speech while motor evoked potentials (MEP) are ized in macaque area F5 by discharging when the monkey performs recorded as an index of excitability of the stimulated motor actions and perceives the actions of others (Ferrari, Gallese, representation (Hallett, 2007). Increases in MEP amplitudes in hand Rizzolatti, & Fogassi, 2003; Gallese, Fadiga, Fogassi, & Rizzolatti, muscles have been demonstrated during observation of hand and 1996; Rizzolatti, Fadiga, Gallese, & Fogassi, 1996). Although still a arm movements performed by another individual (Baldissera, Cavallari, Craighero, & Fadiga, 2001; Clark, Tremblay, & Ste-Marie, 2004; Fadiga, Fogassi, Pavesi, & Rizzolatti, 1995; Strafella & Paus, n Corresponding author. Present address: Department of Neurology, Hertie 2000). In addition, MEP amplitudes of facial or articulatory muscles Institute of Clinical Brain Research, Eberhard-Karls University, Hoppe-Seyler-Str. involved in speech production were facilitated during observation of 3, Tubingen,¨ D-72076, Germany. Tel.: þ49 69 6301 5739; fax: þ49 69 6301 4498. E-mail address: [email protected] (U. Ziemann). speech related lip movements (Murakami, Restle, & Ziemann, 2011; 1 These authors contributed equally to this work. Sundara, Namasivayam, & Chen, 2001; Watkins, Strafella, & Paus, 0028-3932/$ - see front matter & 2012 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.neuropsychologia.2012.05.001 J. Restle et al. / Neuropsychologia 50 (2012) 2026–2031 2027 2003), and even when just listening to speech (Fadiga, Craighero, hypothesized that significant modulating effects of speech repetition Buccino, & Rizzolatti, 2002; Murakami et al., 2011; Watkins et al., accuracy would occur with TBS of pIFG but not MOG, since MOG is 2003). In an experiment that combined TMS of the face representa- involved in visual processing but is not part of the auditory speech tion of the left M1 with positron emission tomography, increases in processing network. MEP amplitude in the facial orbicularis oris muscle correlated To the best of our knowledge this is the first study that directly with metabolic activity in the left pIFG during listening to examines the importance of the left pIFG for speech repetition speech (Watkins & Paus, 2004). These findings supported the notion accuracy by using rTMS. We provide here direct evidence for a that the left pIFG facilitates excitability of the face and articulatory modulating role of the left pIFG in speech repetition. representations of the left M1 during speech perception, and there- fore, operates at the interface of speech perception and articulation. Another technique of investigation is to use TMS in the so 2. Material and Methods called ‘virtual lesion’ mode (Ziemann, 2010). By applying repeti- 2.1. Participants tive TMS (rTMS) over a certain brain area, the activity of the stimulated network is disrupted or facilitated, which should Eighteen healthy right-handed volunteers (mean age7S.D., 26.074.7 years) result, respectively, in decline or improvement of behavioral participated in this study. All subjects were German native speakers and performance if this network is relevant for the performed task. completely naı¨ve to Japanese language. Their educational level was homogenous Two previous virtual lesion studies provided evidence for the as all of them were university students. Handedness was assessed by the importance of the pIFG in sensorimotor integration processing: Edinburgh Handedness Inventory (Oldfield, 1971) with a mean laterality score of 95.178.6%. The study was approved by the Ethics Committee of medical faculty rTMS of pIFG resulted in reduced accuracy of hitting the correct of the Goethe University Frankfurt, and conducted in accordance with the latest target in a finger movement imitation task (Heiser, Iacoboni, version of the Declaration of Helsinki. All participants gave their written informed Maeda, Marcus, & Mazziotta, 2003) and delayed reaction time in consent prior to participation. an automatic finger movement imitation task (Catmur, Walsh, & Heyes, 2009). 2.2. Speech repetition task Here we present two experiments to clarify the role of the left pIFG in sensorimotor integration of speech processing. In the Subjects sat on a comfortable chair while listening to short Japanese poem main experiment we applied theta burst stimulation (TBS) sentences (IROHAKARUTA) presented via dual loudspeakers. The Japanese sen- tences were recorded from a native Japanese male speaker, using a video camera. (Huang, Edwards, Rounis, Bhatia, & Rothwell, 2005), a particular Each sentence consisted of 8 up to 13 syllables and was presented 4 times at form of rTMS, to the left pIFG, and evaluated the effects of three random intertrial intervals of 10–13 s before moving to the next sentence. Forty TBS protocols (cTBS: continuous TBS, iTBS: intermittent TBS, eight different sentences were prepared and divided into 6 different blocks of imTBS: intermediate TBS) on accuracy of speech repetition of a 8 sentences. For each experimental session one block (i.e., consisting of 4 repeats foreign language (Japanese). The task ensured specific testing of  8 sentences¼32 trials) was randomly selected. Subjects were instructed to repeat every sentence immediately after presentation (Fig. 1A, B). Repetition sensorimotor integration of language along the dorsal auditory accuracy was recorded by a digital video camera at every second and fourth stream because the foreign language provided phonological repetition of a given sentence (i.e., 16 trials were evaluated per block of trials). For material
Load more

Recommended publications
  • Vowel Perception and Production in Adolescents with Reading Disabilities
    Vowel Perception and Production in Adolescents with Reading Disabilities Carol Bertucci Lexington Public Schools Lexington, Massachusetts Pamela Hook Charles Haynes MGH Institute of Health Professions Boston, Massachusetts Paul Macaruso Community College of Rhode Island and Haskins Laboratories Providence, Rhode Island and New Haven, Connecticut Corine Bickley Massachusetts Institute of Technology Cambridge, Massachusetts Perception and production of the vowels /i/,I/, /l/el in the words pit, pet and pat were investigated in two groups of adolescents who differed significantly on measures of reading and phonological aware- ness. Perception performance was assessed using slope measurements between vowel categories. Duration measurements and a rating sys- tem based on first and second formant (Fl and F2) values were used to analyze production performance. As a group, the students with read- ing disabilities not only perceived but also produced less well-defined vowel categories than the control group of age-matched good readers. Perception and production performance, however, were not correlated. Results suggest that the speech processing difficulties of the students with reading disabilities include weak phonological coding for vowel sounds with similar phonetic characteristics.The implications of these findings for intervention are addressed. Annals of Dyslexia, Vol. 53,2003 Copyright ©2003by The International Dyslexia Association® ISSN 0736-9387 174 VOWEL PERCEPTION AND PRODUCTION 175 Learning to read an alphabetic writing system such as English involves establishing sound-symbol correspondences. Although it is not dear exactly how this process takes place, it presumably involves several factors: for example, the ability to perceive and discriminate speech sounds, the capacity to form and store cate- gories of speech sounds, and the ability to link these categories with specific orthographic symbols.
    [Show full text]
  • Anatomical Evidence of an Indirect Pathway for Word Repetition
    Published Ahead of Print on January 29, 2020 as 10.1212/WNL.0000000000008746 ARTICLE OPEN ACCESS Anatomical evidence of an indirect pathway for word repetition Stephanie J. Forkel, PhD, Emily Rogalski, PhD, Niki Drossinos Sancho, MSc, Lucio D’Anna, MD, PhD, Correspondence Pedro Luque Laguna, PhD, Jaiashre Sridhar, MSc, Flavio Dell’Acqua, PhD, Sandra Weintraub, PhD, Dr. Catani Cynthia Thompson, PhD, M.-Marsel Mesulam, MD, and Marco Catani, MD, PhD [email protected] Neurology® 2020;94:e1-e13. doi:10.1212/WNL.0000000000008746 Abstract Objective To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). Methods The traditional anatomical model of language identifies a network for word repetition that includes Wernicke and Broca regions directly connected via the arcuate fasciculus. Recent tractography findings of an indirect pathway between Wernicke and Broca regions suggest a critical role of the inferior parietal lobe for repetition. To test whether repetition deficits are associated with damage to the direct or indirect pathway between both regions, tractography analysis was performed in 30 patients with PPA (64.27 ± 8.51 years) and 22 healthy controls. Cortical volume measurements were also extracted from 8 perisylvian language areas connected by the direct and indirect pathways. Results Compared to healthy controls, patients with PPA presented with reduced performance in repetition tasks and increased damage to most of the perisylvian cortical regions and their connections through the indirect pathway. Repetition deficits were prominent in patients with cortical atrophy of the temporo-parietal region with volumetric reductions of the indirect pathway.
    [Show full text]
  • Anaphora As an Essential Type of Poetic Figures
    European Journal of Research Development and Sustainability (EJRDS) Available Online at: https://www.scholarzest.com Vol. 2 No. 3, March 2021, ISSN: 2660-5570 ANAPHORA AS AN ESSENTIAL TYPE OF POETIC FIGURES Karimova Shakhnozaxon Karimovna Bukhara state university Department of Foreign languages on Natural directions [email protected] Article history: Abstract: Received: 26th February 2021 This article discusses the main role and use of anaphora in poetry, which is one Accepted: 7th March 2021 of the poetic repetitions. The role of anaphora in the poem is great. It gives the Published: 28h March 2021 verse great expressiveness, imagery and brightness. This technique is, as it were, a kind of poet's voice, helping to understand the mental and emotional state of the author. Anaphora is a stylistic figure of speech, it consists in repeating the same elements (sounds, words, phrases) at the beginning of each parallel row (stanza, verse, etc.) Keywords: Poetic syntax, poetic speech, repetition, tropes and figures of speech, poetic figures, anaphora It is well known that in linguistics the syntax is concerned with the construction of speech, the order of words in a sentence, while in poetry (in poetic speech) the syntax deals with the construction of sentences in bytes, bytes and lines and the order of parts. the speech in them is used. In poetic speech, especially in composing poetic sentences, it is important to choose words and use them skillfully in speech construction. The syntax of poetic speech gives the language of the work figurativeness, expressiveness, charm.[1] The author's syntax is directly influenced by the general features of his poetry - after all it is precisely within the framework of poetic syntax that the writer‟s creative talent lies in his syntactic structure can be determined by its specific properties.[2] The role of poetic speech in the organization of speech is great, its musicality, emotional intensity and sensitivity depend in many respects on poetic syntax.
    [Show full text]
  • Repetitions in the Speech of Normal Two Year Old Males
    Portland State University PDXScholar Dissertations and Theses Dissertations and Theses 1987 Repetitions in the speech of normal two year old males Stephanie Herrick Portland State University Follow this and additional works at: https://pdxscholar.library.pdx.edu/open_access_etds Part of the Speech Pathology and Audiology Commons Let us know how access to this document benefits ou.y Recommended Citation Herrick, Stephanie, "Repetitions in the speech of normal two year old males" (1987). Dissertations and Theses. Paper 3746. https://doi.org/10.15760/etd.5630 This Thesis is brought to you for free and open access. It has been accepted for inclusion in Dissertations and Theses by an authorized administrator of PDXScholar. Please contact us if we can make this document more accessible: [email protected]. AN ABSTRACT OF THE THESIS OF Stephanie Herrick for the Master of Science in Speech Communication presented July 23, 1987. Title: Repetitions in the Speech of Normal Two Year Old Males. APPROVED BY MEMBERS OF THE THESIS COMMITTEE: n McMahon Baxter D. Wilson Development of fluency has always been an important focus of stuttering research. However, to date there are no standardized norms on the development of fluency. Reliable and valid information regarding the normal development of fluency is necessary in order to differentially diagnose normal disfluency from incipient stuttering. Establishment of norms for part-word repetitions is especially important since this type of disfluency has traditionally been considered an indicator of early stuttering. The present study sought to PORTlAHD STATE UNIVERSITY LIBRARY 2 contribute to the investigation of the development of fluency by examining the frequency of occurrence of repetitions in 30- to 36-month-old males.
    [Show full text]
  • Neuroanatomical Correlates of Speech and Melody Repetition in Chronic Stroke Sarah Elizabeth Bradford University of South Carolina
    University of South Carolina Scholar Commons Theses and Dissertations 2018 Neuroanatomical Correlates Of Speech And Melody Repetition In Chronic Stroke Sarah Elizabeth Bradford University of South Carolina Follow this and additional works at: https://scholarcommons.sc.edu/etd Part of the Speech Pathology and Audiology Commons Recommended Citation Bradford, S. E.(2018). Neuroanatomical Correlates Of Speech And Melody Repetition In Chronic Stroke. (Master's thesis). Retrieved from https://scholarcommons.sc.edu/etd/4893 This Open Access Thesis is brought to you by Scholar Commons. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. NEUROANATOMICAL CORRELATES OF SPEECH AND MELODY REPETITION IN CHRONIC STROKE by Sarah Elizabeth Bradford Bachelor of Science University of South Carolina, 2016 Submitted in Partial Fulfillment of the Requirements For the Degree of Master of Speech Pathology in Speech Pathology The Norman J. Arnold School of Public Health University of South Carolina 2018 Accepted by: Julius Fridriksson, Director of Thesis Dirk den Ouden, Reader Alexandra Basilakos, Reader Cheryl L. Addy, Vice Provost and Dean of the Graduate School © Copyright by Sarah Elizabeth Bradford, 2018 All Rights Reserved. ii DEDICATION This document is dedicated to the speech-language pathologists and early interventionists who gave me the chance to succeed in this life. Your kindness and dedication to my family and myself has inspired a career of giving others the chance to communicate again. Thank you for giving me the skills I needed to write this document and making all of what I love about this life possible.
    [Show full text]
  • The Neuroanatomy of Speech Sequencing at the Syllable Level
    The Neuroanatomy of Speech Sequencing at the Syllable Level Feng Rong1, A. Lisette Isenberg1, Erica Sun1, Gregory Hickok1, CA 1. Department of Cognitive Sciences, University of California, Irvine. Irvine, CA 92697. [email protected] Grant support: NIDCD R01 DC009659 ABSTRACT Correctly ordering a sequence of speech sounds is a crucial aspect of speech production. Although studies have yielded a rich body of data on the neural substrates of visuomotor sequencing and sequence learning, research on brain regions and their functions involving speech sequence production hasn’t attracted much attention until recently. Previous functional MRI studies manipulating the complexity of sequences at the phonemic, syllabic, and suprasyllabic levels have revealed a network of motor-related cortical and sub-cortical speech regions. In this study, we directly compared human brain activity measured with functional MRI during processing of a sequence of syllables compared with the same syllables processed individually. Among a network of regions independently identified as being part of the sensorimotor circuits for speech production, only the left posterior inferior frontal gyrus (pars opercularis, lIFG), the supplementary motor area (SMA), and the left inferior parietal lobe (lIPL) responded more during the production of syllable sequences compared to producing the same syllables articulated one at a time. Introduction Fluent speech requires the rapid coordination of vocal tract gestures to produce the intended sequence of phonemes (segments), syllables, and words. Speech error data (slips of the tongue, Spoonerisms) have illuminated the process, providing direct evidence for sequence planning over multiple representational levels (Dell, 1995; Fromkin, 1971; Garrett, 1975; W. J. M. Levelt, 1989; Shattuck-Hufnagel, 1992).
    [Show full text]
  • Phonetic and Cognitive Bases of Sound Change by Reiko Kataoka A
    Phonetic and Cognitive Bases of Sound Change by Reiko Kataoka A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Linguistics in the Graduate Division of the University of California, Berkeley Committee in charge: Professor John J. Ohala, Co-Chair Professor Keith Johnson, Co-Chair Professor Andrew Garrett Professor Yoko Hasegawa Fall 2011 Phonetic and Cognitive Bases of Sound Change © 2011 by Reiko Kataoka 1 Abstract Phonetic and Cognitive Bases of Sound Change by Reiko Kataoka Doctor of Philosophy in Linguistics University of California, Berkeley Professor John J. Ohala, Professor Keith Johnson, Co-Chairs In this dissertation I investigated, by using coarticulatory /u/-fronting in the alveolar context for a case study, how native speakers of American English produce coarticulatory variations and how they perceive and reproduce continuously varying speech sounds that are heard in coarticulatory and non-coarticulatory contexts. The production study addressed the question of whether in American English coarticulatory fronting of /u/ in alveolar contexts is an inevitable consequence of production constraints or if it is produced by active speaker control. The study found that: (1) the relative acoustic difference between the fronted /u/ and the non-fronted /u/ remained across an elicited range of vowel duration; and (2) the degree of acoustic variability was less for the fronted /u/ than the non- fronted /u/. These results indicate that speakers of American English have a distinct and more narrowly specified articulatory target for the fronted /u/ in the alveolar context than for the non- fronted /u/. The perception study addressed the issue of individual variation and compensation for coarticulation.
    [Show full text]
  • Phonetic and Cognitive Bases of Sound Change
    Phonetic and Cognitive Bases of Sound Change by Reiko Kataoka A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Linguistics in the Graduate Division of the University of California, Berkeley Committee in charge: Professor John J. Ohala, Co-Chair Professor Keith Johnson, Co-Chair Professor Andrew Garrett Professor Yoko Hasegawa Fall 2011 Phonetic and Cognitive Bases of Sound Change © 2011 by Reiko Kataoka 1 Abstract Phonetic and Cognitive Bases of Sound Change by Reiko Kataoka Doctor of Philosophy in Linguistics University of California, Berkeley Professor John J. Ohala, Professor Keith Johnson, Co-Chairs In this dissertation I investigated, by using coarticulatory /u/-fronting in the alveolar context for a case study, how native speakers of American English produce coarticulatory variations and how they perceive and reproduce continuously varying speech sounds that are heard in coarticulatory and non-coarticulatory contexts. The production study addressed the question of whether in American English coarticulatory fronting of /u/ in alveolar contexts is an inevitable consequence of production constraints or if it is produced by active speaker control. The study found that: (1) the relative acoustic difference between the fronted /u/ and the non-fronted /u/ remained across an elicited range of vowel duration; and (2) the degree of acoustic variability was less for the fronted /u/ than the non- fronted /u/. These results indicate that speakers of American English have a distinct and more narrowly specified articulatory target for the fronted /u/ in the alveolar context than for the non- fronted /u/. The perception study addressed the issue of individual variation and compensation for coarticulation.
    [Show full text]
  • An Experimental Study of Fluency Development and Proceduralization
    Language Learning ISSN 0023-8333 Fluency Training in the ESL Classroom: An Experimental Study of Fluency Development and Proceduralization Nel de Jong Vrije Universiteit Amsterdam Charles A. Perfetti University of Pittsburgh The present study investigates the role of speech repetition in oral fluency development. Twenty-four students enrolled in English-as-a-second-language classes performed three training sessions in which they recorded three speeches, of 4, 3, and 2 min, respectively. Some students spoke about the same topic three times, whereas others spoke about three different topics. It was found that fluency improved for both groups during training but was maintained on posttests only by the students who repeated their speeches. These students had used more words repeatedly across speeches, most of which were not specif- ically related to the topic. It is argued that proceduralization of linguistic knowledge represented a change in underlying cognitive mechanisms, resulting in improvements in observable fluency. Keywords classroom research; English as a second language; fluency training; oral fluency; proceduralization; second language; task repetition; vocabulary The ultimate goal of many second-language (L2) learners is to be fluent in the target language—that is, to be able to express their thoughts easily, with more The data of the pretests and posttests were presented at the AAAL conference in Costa Mesa, CA, on April 24, 2007. The authors would like to thank Colleen Davy, Jessica Hogan, Rhonda McClain, and Laura Halderman for their contributions to transcription, coding, and analysis of the data from the training sessions. Thanks to Laura Halderman, Mary Lou Vercellotti, and Scott Walters for their feedback to drafts of this article.
    [Show full text]
  • I'm Not a Doctor! a Reappraisal of Mitigated Echolalia in Aphasia with Evaluation of N
    Aphasiology ISSN: 0268-7038 (Print) 1464-5041 (Online) Journal homepage: http://www.tandfonline.com/loi/paph20 Are you a doctor? … Are you a doctor? I’m not a doctor! A reappraisal of mitigated echolalia in aphasia with evaluation of neural correlates and treatment approaches Marcelo L. Berthier, María José Torres-Prioris, Diana López-Barroso, Karl Thurnhofer-Hemsi, José Paredes-Pacheco, Núria Roé-Vellvé, Francisco Alfaro, Lucía Pertierra & Guadalupe Dávila To cite this article: Marcelo L. Berthier, María José Torres-Prioris, Diana López-Barroso, Karl Thurnhofer-Hemsi, José Paredes-Pacheco, Núria Roé-Vellvé, Francisco Alfaro, Lucía Pertierra & Guadalupe Dávila (2017): Are you a doctor? … Are you a doctor? I’m not a doctor! A reappraisal of mitigated echolalia in aphasia with evaluation of neural correlates and treatment approaches, Aphasiology, DOI: 10.1080/02687038.2016.1274875 To link to this article: http://dx.doi.org/10.1080/02687038.2016.1274875 View supplementary material Published online: 21 Jan 2017. Submit your article to this journal Article views: 217 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=paph20 Download by: [UMA University of Malaga] Date: 18 April 2017, At: 01:37 APHASIOLOGY, 2017 http://dx.doi.org/10.1080/02687038.2016.1274875 Are you a doctor? . Are you a doctor? I’m not a doctor! A reappraisal of mitigated echolalia in aphasia with evaluation of neural correlates and treatment approaches Marcelo
    [Show full text]
  • Sources of Phoneme Errors in Repetition: Perseverative, Neologistic, and Lesion Patterns in Jargon Aphasia
    Sources of phoneme errors in repetition: perseverative, neologistic and lesion patterns in jargon aphasia PILKINGTON, Emma, KEIDEL, James, KENDRICK, Luke, SADDY, Doug, SAGE, Karen <http://orcid.org/0000-0002-7365-5177> and ROBSON, Holly Available from Sheffield Hallam University Research Archive (SHURA) at: http://shura.shu.ac.uk/15564/ This document is the author deposited version. You are advised to consult the publisher's version if you wish to cite from it. Published version PILKINGTON, Emma, KEIDEL, James, KENDRICK, Luke, SADDY, Doug, SAGE, Karen and ROBSON, Holly (2017). Sources of phoneme errors in repetition: perseverative, neologistic and lesion patterns in jargon aphasia. Frontiers in Human Neuroscience, 11, p. 225. Copyright and re-use policy See http://shura.shu.ac.uk/information.html Sheffield Hallam University Research Archive http://shura.shu.ac.uk ORIGINAL RESEARCH published: 04 May 2017 doi: 10.3389/fnhum.2017.00225 Sources of Phoneme Errors in Repetition: Perseverative, Neologistic, and Lesion Patterns in Jargon Aphasia Emma Pilkington 1, James Keidel 2, Luke T. Kendrick 1, James D. Saddy 1, Karen Sage 3, 4* and Holly Robson 1 1 School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK, 2 School of Psychology, University of Sussex, Brighton, UK, 3 Department of Allied Health Professions, Sheffield Hallam University, Sheffield, UK, 4 Centre for Health and Social Care, Sheffield Hallam University, Sheffield, UK This study examined patterns of neologistic and perseverative errors during word repetition in fluent Jargon aphasia. The principal hypotheses accounting for Jargon production indicate that poor activation of a target stimulus leads to weakly activated target phoneme segments, which are outcompeted at the phonological encoding level.
    [Show full text]
  • Influences on Nonword Repetition in Young Children Dana Arthur University of Connecticut - Storrs, [email protected]
    University of Connecticut OpenCommons@UConn Doctoral Dissertations University of Connecticut Graduate School 8-14-2017 Influences on Nonword Repetition in Young Children Dana Arthur University of Connecticut - Storrs, [email protected] Follow this and additional works at: https://opencommons.uconn.edu/dissertations Recommended Citation Arthur, Dana, "Influences on Nonword Repetition in Young Children" (2017). Doctoral Dissertations. 1603. https://opencommons.uconn.edu/dissertations/1603 Influences on Nonword Repetition in Young Children Dana Thorne Arthur, PhD University of Connecticut, 2017 Abstract Nonword repetition (NWR) tasks have become popular in recent years as measures of phonological short term memory (PSTM) in research settings, and as potential markers of language impairment in clinical settings. This has increased interest in the subskills that potentially NWR performance. The current study investigated the influence of PSTM, vocabulary skills, articulatory output skills, literacy, and speech perception on NWR in children ages 4;0-6;5. Partial correlations and regression analysis were used to establish an in-depth picture of the skills that constrain NWR, and to differentiate the skills that underlie this measure when the language skills of test takers and the wordlikeness of NWR items were taken into account. Results indicated that both PSTM and vocabulary were independently related to NWR performance when the entire sample was considered. When the sample was divided by language scores, higher-scoring participants’ NWR performance was influenced by PSTM, while only vocabulary scores were related to NWR performance in lower-language scoring children. Wordlikeness of nonword items also affected the skills related to NWR performance, in that scores on highly wordlike stimuli were principally related to vocabulary skills, while scores on less wordlike stimuli were significantly related to PSTM only.
    [Show full text]