Journal of Clinical Medicine Review Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management Miguel A. Ortega 1,2,3,† , Oscar Fraile-Martínez 1,2,† , Cielo García-Montero 1,2,† , Miguel A. Álvarez-Mon 1,2,*, Chen Chaowen 1, Fernando Ruiz-Grande 4,5, Leonel Pekarek 1,2 , Jorge Monserrat 1,2 , Angel Asúnsolo 2,4,6 , Natalio García-Honduvilla 1,2,‡ , Melchor Álvarez-Mon 1,2,7,‡ and Julia Bujan 1,2,‡ 1 Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain;
[email protected] (M.A.O.);
[email protected] (O.F.-M.);
[email protected] (C.G.-M.);
[email protected] (C.C.);
[email protected] (L.P.);
[email protected] (J.M.);
[email protected] (N.G.-H.);
[email protected] (M.Á.-M.);
[email protected] (J.B.) 2 Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain;
[email protected] 3 Cancer Registry and Pathology Department, Hospital Universitario Principe de Asturias, 28806 Alcalá de Henares, Spain 4 Department of Surgery, Medical and Social Sciences, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain;
[email protected] 5 Department of Vascular Surgery, Príncipe de Asturias Hospital, 28801 Alcalá de Henares, Spain 6 Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, The City University of New York, New York, NY 10027, USA 7 Citation: Ortega, M.A.; Immune System Diseases—Rheumatology and Internal Medicine Service, University Hospital Príncipe de Fraile-Martínez, O.; García-Montero, Asturias, (CIBEREHD), 28806 Alcalá de Henares, Spain * Correspondence:
[email protected] C.; Álvarez-Mon, M.A.; Chaowen, C.; † These authors contributed equality in this work.